y a o g aaaaaaaaaaaaaaaaaaaaaaaaaaaa 3 3 7 12 ---------|----------|---|--- 14 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase 1 3 3 9 ------------------------|-|| 9 [I] COG1133 ABC-type long-chain fatty acid transport system, fused permease and ATPase components 2 3 6 9 ------------------|-----||-- 9 [C] COG1347 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD 3 3 3 4 -|----------|---------|----- 4 [H] COG1424 Pimeloyl-CoA synthetase 3 3 3 6 ------------||------|------- 6 [S] COG1507 Uncharacterized conserved protein 3 3 3 6 -------------|-----|--|----- 9 [R] COG1647 Esterase/lipase 3 3 3 4 -------------|-----|-|------ 4 [S] COG1655 Uncharacterized protein conserved in bacteria 3 3 3 4 ------------||------|------- 4 [S] COG1659 Uncharacterized protein, linocin/CFP29 homolog 1 3 3 4 |----||--------------------- 4 [S] COG1689 Uncharacterized protein conserved in archaea 2 3 3 3 |----|------|--------------- 3 [S] COG1700 Uncharacterized conserved protein 1 3 3 4 ||---|---------------------- 4 [S] COG1710 Uncharacterized protein conserved in archaea 2 3 6 9 ------------------|-----||-- 9 [C] COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA 3 3 3 4 ----------------|-|--|------ 4 [R] COG1768 Predicted phosphohydrolase 3 3 3 3 ------|-----||-------------- 3 [L] COG1769 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 1 3 3 4 ||---|---------------------- 4 [S] COG1771 Uncharacterized protein conserved in archaea 3 3 4 5 -------------------|--|-|--- 7 [R] COG1783 Phage terminase large subunit 1 3 3 3 -|---||--------------------- 6 [R] COG1800 Predicted transglutaminase-like proteases 1 3 3 4 ||---|---------------------- 8 [S] COG1822 Predicted archaeal membrane protein 2 3 3 4 -|---|------|--------------- 4 [S] COG1851 Uncharacterized conserved protein 2 3 3 8 ------------|-----------|-|- 9 [C] COG1969 Ni,Fe-hydrogenase I cytochrome b subunit 1 3 3 4 -|---||--------------------- 4 [S] COG2028 Uncharacterized conserved protein 2 3 3 10 --------------------|---|-|- 10 [I] COG2134 CDP-diacylglycerol pyrophosphatase 3 3 3 4 ------------||------------|- 5 [O] COG2143 Thioredoxin-related protein 2 3 3 3 |-----|------|-------------- 3 [S] COG2164 Uncharacterized conserved protein 3 3 6 12 |------------|----------|--- 12 [P] COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur 2 3 6 9 ------------------|-----||-- 10 [C] COG2209 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE 2 3 3 4 -|---|----------------|----- 9 [M] COG2247 Putative cell wall-binding domain 2 3 3 5 ---|-|--------------|------- 9 [S] COG2253 Uncharacterized conserved protein 3 3 3 3 ------|------|--|----------- 3 [R] COG2316 Predicted hydrolase (HD superfamily) 3 3 5 10 ----------------|-----|-|--- 10 [L] COG2356 Endonuclease I 3 3 3 3 ------------||--|----------- 3 [S] COG2380 Uncharacterized protein conserved in bacteria 2 3 4 5 -----||-|------------------- 5 [C] COG2441 Predicted butyrate kinase 1 3 3 4 ||---|---------------------- 4 [S] COG2456 Uncharacterized conserved protein 2 3 4 7 -|----------------------|-|- 8 [R] COG2603 Predicted ATPase 3 3 3 5 -------------------|-|----|- 17 [S] COG2604 Uncharacterized protein conserved in bacteria 2 3 5 12 ---------------------|--|-|- 21 [R] COG2704 Anaerobic C4-dicarboxylate transporter 3 3 3 4 -----|--|-------|----------- 4 [V] COG2810 Predicted type IV restriction endonuclease 2 3 3 9 ----------------------|-||-- 9 [P] COG2822 Predicted periplasmic lipoprotein involved in iron transport 1 3 4 11 ------------------------|||- 11 [M] COG2829 Outer membrane phospholipase A 1 3 3 5 ------------------------|||- 5 [S] COG2830 Uncharacterized protein conserved in bacteria 2 3 7 13 ----------------------|-||-- 14 [S] COG2850 Uncharacterized conserved protein 2 3 6 9 ------------------|-----||-- 9 [C] COG2869 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC 2 3 6 9 ------------------|-----||-- 9 [C] COG2871 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF 1 3 5 10 ------------------------|||- 12 [S] COG2879 Uncharacterized small protein 1 3 7 16 ------------------------||-| 16 [S] COG2900 Uncharacterized protein conserved in bacteria 1 3 7 13 ------------------------||-| 14 [S] COG2904 Uncharacterized protein conserved in bacteria 3 3 5 10 --------------------||--|--- 13 [K] COG2909 ATP-dependent transcriptional regulator 1 3 9 19 ------------------------||-| 19 [S] COG2911 Uncharacterized protein conserved in bacteria 1 3 10 21 ------------------------||-| 24 [J] COG2913 Small protein A (tmRNA-binding) 1 3 9 19 ------------------------||-| 19 [D] COG2917 Intracellular septation protein A 2 3 6 11 ---------------------||-|--- 11 [H] COG2918 Gamma-glutamylcysteine synthetase 3 3 6 12 ------|-|---------------|--- 12 [P] COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit 1 3 10 20 ------------------------||-| 20 [L] COG2927 DNA polymerase III, chi subunit 1 3 6 9 ------------------------||-| 9 [M] COG2943 Membrane glycosyltransferase 2 3 4 5 ----------------------|-||-- 10 [L] COG2946 Putative phage replication protein RstA 3 3 5 10 --------------|-|-------|--- 14 [S] COG2949 Uncharacterized membrane protein 1 3 4 6 ------------------------|||- 6 [S] COG2958 Uncharacterized protein conserved in bacteria 1 3 7 15 ------------------------||-| 15 [S] COG2960 Uncharacterized protein conserved in bacteria 1 3 10 19 ------------------------||-| 19 [R] COG2961 Protein involved in catabolism of external DNA 2 3 5 14 --------------------|---|--| 14 [Q] COG2977 Phosphopantetheinyl transferase component of siderophore synthetase 1 3 6 13 ------------------------||-| 13 [S] COG2979 Uncharacterized protein conserved in bacteria 2 3 6 14 ---------------|--------|--| 14 [E] COG2981 Uncharacterized protein involved in cysteine biosynthesis 1 3 7 15 ------------------------||-| 23 [M] COG2982 Uncharacterized protein involved in outer membrane biogenesis 2 3 7 15 -|----------------------|--| 15 [S] COG2983 Uncharacterized conserved protein 2 3 5 9 --------------||--------|--- 9 [E] COG2988 Succinylglutamate desuccinylase 2 3 4 7 -----------------|------|-|- 7 [R] COG2992 Uncharacterized FlgJ-related protein 3 3 3 4 ------------|---------|-|--- 4 [S] COG3002 Uncharacterized protein conserved in bacteria 1 3 7 16 ------------------------|-|| 18 [P] COG3004 Na+/H+ antiporter 1 3 6 12 ------------------------|-|| 26 [C] COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit 2 3 4 4 ------------|-----------|-|- 4 [S] COG3016 Uncharacterized iron-regulated protein 1 3 8 16 ------------------------||-| 16 [S] COG3024 Uncharacterized protein conserved in bacteria 1 3 6 12 ------------------------|-|| 12 [C] COG3043 Nitrate reductase cytochrome c-type subunit 1 3 6 14 ------------------------||-| 14 [S] COG3045 Uncharacterized protein conserved in bacteria 1 3 9 16 ------------------------||-| 19 [M] COG3047 Outer membrane protein W 3 3 5 9 -----------------|----|-|--- 9 [E] COG3048 D-serine dehydratase 3 3 5 9 -----------------|----|-|--- 10 [C] COG3051 Citrate lyase, alpha subunit 3 3 5 9 -----------------|----|-|--- 10 [C] COG3052 Citrate lyase, gamma subunit 3 3 5 9 -----------------|----|-|--- 10 [C] COG3053 Citrate lyase synthetase 2 3 5 10 -----------------|------|--| 13 [S] COG3055 Uncharacterized protein conserved in bacteria 2 3 5 10 ------------|-----------|--| 10 [O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation 1 3 6 12 ------------------------|-|| 12 [P] COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase 3 3 6 11 -------------|---|------|--- 12 [T] COG3086 Positive regulator of sigma E activity 2 3 7 15 ----------------|-------|--| 22 [O] COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes 1 3 6 13 ------------------------||-| 13 [Q] COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component 2 3 7 13 ----------------------|-|--| 30 [S] COG3152 Predicted membrane protein 1 3 5 11 ------------------------||-| 11 [I] COG3154 Putative lipid carrier protein 1 3 7 8 ------------------------||-| 9 [U] COG3156 Type II secretory pathway, component PulK 1 3 5 10 ------------------------||-| 28 [S] COG3157 Hemolysin-coregulated protein (uncharacterized) 1 3 7 11 ------------------------||-| 11 [S] COG3159 Uncharacterized protein conserved in bacteria 2 3 5 6 ----------------|-------|--| 6 [S] COG3169 Uncharacterized protein conserved in bacteria 3 3 5 11 --------------------|-|-|--- 11 [H] COG3172 Predicted ATPase/kinase involved in NAD metabolism 1 3 6 10 ------------------------||-| 10 [R] COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases 2 3 5 5 ----------------|-------|--| 8 [R] COG3179 Predicted chitinase 1 3 4 8 ------------------------||-| 8 [S] COG3184 Uncharacterized protein conserved in bacteria 3 3 4 8 -----------------|----|-|--- 8 [E] COG3192 Ethanolamine utilization protein 1 3 5 8 ------------------------||-| 12 [P] COG3213 Uncharacterized protein involved in response to NO 2 3 4 7 ---------------|--------|--| 8 [S] COG3216 Uncharacterized protein conserved in bacteria 1 3 5 8 ------------------------|-|| 8 [R] COG3218 ABC-type uncharacterized transport system, auxiliary component 2 3 4 6 -------------|----------||-- 6 [S] COG3234 Uncharacterized protein conserved in bacteria 2 3 7 7 --------------|---------||-- 9 [IR] COG3240 Phospholipase/lecithinase/hemolysin 1 3 6 11 ------------------------||-| 11 [S] COG3242 Uncharacterized protein conserved in bacteria 1 3 5 6 ------------------------||-| 10 [C] COG3245 Cytochrome c5 2 3 4 10 ----------------|-------|--| 10 [R] COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization 2 3 5 9 |-|---------------------|--- 9 [S] COG3272 Uncharacterized conserved protein 3 3 5 9 --------------------|-|-|--- 20 [T] COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism 2 3 4 4 --------------||--------|--- 5 [T] COG3292 Predicted periplasmic ligand-binding sensor domain 2 3 5 8 ----------------------|-||-- 13 [S] COG3299 Uncharacterized homolog of phage Mu protein gp47 3 3 5 9 ------|-|---------------|--- 10 [P] COG3301 Formate-dependent nitrite reductase, membrane component 2 3 4 9 ------------|-----------|--| 19 [R] COG3302 DMSO reductase anchor subunit 2 3 5 11 --------------------|---|--| 11 [S] COG3304 Predicted membrane protein 1 3 4 5 ------------------------|||- 6 [S] COG3309 Uncharacterized virulence-associated protein D 1 3 5 11 ------------------------||-| 25 [K] COG3311 Predicted transcriptional regulator 1 3 6 12 ------------------------||-| 16 [R] COG3313 Predicted Fe-S protein 3 3 3 3 ------|-----|---------|----- 3 [L] COG3337 Uncharacterized protein predicted to be involved in DNA repair 3 3 5 5 -------------|--------|-|--- 5 [G] COG3345 Alpha-galactosidase 3 3 3 4 ---|----------------|-|----- 4 [S] COG3361 Uncharacterized conserved protein 2 3 5 6 ----|-|-|------------------- 8 [S] COG3370 Uncharacterized protein conserved in archaea 2 3 5 7 ----||--|------------------- 12 [S] COG3371 Predicted membrane protein 1 3 3 5 -|--||---------------------- 5 [S] COG3373 Uncharacterized protein conserved in archaea 3 3 3 4 ----|---|-------|----------- 5 [S] COG3375 Uncharacterized conserved protein 2 3 4 4 ---|-|--|------------------- 5 [S] COG3379 Uncharacterized conserved protein 3 3 3 5 -----------------|----|---|- 6 [L] COG3392 Adenine-specific DNA methylase 2 3 4 10 ----------------------|-|--| 12 [S] COG3394 Uncharacterized protein conserved in bacteria 3 3 3 7 ---|----------------|-|----- 7 [S] COG3402 Uncharacterized conserved protein 3 3 3 3 ---|------------|-----|----- 4 [S] COG3403 Uncharacterized conserved protein 1 3 5 5 ------------------------||-| 5 [S] COG3416 Uncharacterized protein conserved in bacteria 3 3 3 5 ----------------|---|-|----- 10 [Q] COG3424 Predicted naringenin-chalcone synthase 3 3 3 8 ---|----------------|-|----- 8 [S] COG3428 Predicted membrane protein 3 3 3 3 ------------|---------|-|--- 6 [T] COG3434 Predicted signal transduction protein containing EAL and modified HD-GYP domains 2 3 4 11 ----------------------|-|--| 11 [R] COG3443 Predicted periplasmic or secreted protein 1 3 4 8 ------------------------||-| 11 [S] COG3453 Uncharacterized protein conserved in bacteria 2 3 4 10 --------------|---------|--| 14 [P] COG3454 Metal-dependent hydrolase involved in phosphonate metabolism 1 3 5 9 ------------------------||-| 16 [S] COG3455 Uncharacterized protein conserved in bacteria 3 3 4 6 -------------|--------|----| 7 [Q] COG3458 Acetyl esterase (deacetylase) 3 3 3 4 ----|--------|-------------| 4 [S] COG3461 Uncharacterized conserved protein 2 3 3 4 ---||--------|-------------- 5 [S] COG3462 Predicted membrane protein 2 3 3 5 ----||---------|------------ 7 [S] COG3463 Predicted membrane protein 2 3 3 5 ----|-|---------------|----- 5 [S] COG3465 Uncharacterized conserved protein 1 3 3 3 -|--|-|--------------------- 9 [S] COG3466 Putative transposon-encoded protein 1 3 4 13 ------------------------||-| 55 [MU] COG3468 Type V secretory pathway, adhesin AidA 2 3 5 9 ---------||----------------| 21 [C] COG3474 Cytochrome c2 2 3 4 7 ----------------------|-|-|- 7 [S] COG3477 Predicted periplasmic/secreted protein 3 3 5 7 -----------------|----|-|--- 8 [C] COG3493 Na+/citrate symporter 3 3 5 9 ------------|----|---------| 9 [S] COG3494 Uncharacterized protein conserved in bacteria 2 3 4 6 --------------------|---|--| 6 [S] COG3496 Uncharacterized conserved protein 1 3 5 7 ------------------------||-| 8 [R] COG3499 Phage protein U 3 3 3 6 ---------------|----|------| 6 [V] COG3510 Cephalosporin hydroxylase 1 3 4 8 ------------------------||-| 9 [S] COG3514 Uncharacterized protein conserved in bacteria 1 3 5 9 ------------------------||-| 22 [S] COG3515 Uncharacterized protein conserved in bacteria 1 3 5 9 ------------------------||-| 15 [S] COG3516 Uncharacterized protein conserved in bacteria 1 3 5 9 ------------------------||-| 16 [S] COG3517 Uncharacterized protein conserved in bacteria 1 3 5 9 ------------------------||-| 14 [S] COG3518 Uncharacterized protein conserved in bacteria 1 3 5 9 ------------------------||-| 13 [S] COG3519 Uncharacterized protein conserved in bacteria 1 3 5 9 ------------------------||-| 15 [S] COG3520 Uncharacterized protein conserved in bacteria 1 3 5 8 ------------------------||-| 12 [S] COG3521 Uncharacterized protein conserved in bacteria 1 3 5 9 ------------------------||-| 15 [S] COG3522 Uncharacterized protein conserved in bacteria 1 3 5 9 ------------------------||-| 15 [S] COG3523 Uncharacterized protein conserved in bacteria 2 3 5 7 ----------------------|-|--| 8 [G] COG3525 N-acetyl-beta-hexosaminidase 1 3 5 5 ------------------------||-| 8 [O] COG3531 Predicted protein-disulfide isomerase 1 3 4 8 ------------------------||-| 9 [S] COG3536 Uncharacterized protein conserved in bacteria 3 3 4 7 ----------|-----------|-|--- 8 [S] COG3538 Uncharacterized conserved protein 2 3 5 6 --------------|---------|--| 8 [R] COG3549 Plasmid maintenance system killer protein 2 3 3 3 ----------------------|-|--| 3 [S] COG3551 Uncharacterized protein conserved in bacteria 2 3 3 5 --------------------|---|--| 6 [S] COG3554 Uncharacterized protein conserved in bacteria 2 3 3 4 ---------------|--------|--| 4 [S] COG3558 Uncharacterized protein conserved in bacteria 3 3 3 6 --------------------|-|----| 6 [S] COG3564 Uncharacterized protein conserved in bacteria 2 3 3 4 ---------------|--------|--| 4 [R] COG3565 Predicted dioxygenase of extradiol dioxygenase family 2 3 4 4 ----------------------|-|--| 5 [S] COG3566 Uncharacterized protein conserved in bacteria 2 3 4 4 ----------------------|-|--| 5 [S] COG3567 Uncharacterized protein conserved in bacteria 2 3 3 5 ----------------|-------|--| 5 [V] COG3570 Streptomycin 6-kinase 2 3 3 5 --------------------|---|--| 5 [R] COG3571 Predicted hydrolase of the alpha/beta-hydrolase fold 3 3 3 6 ----------------|---|------| 6 [R] COG3573 Predicted oxidoreductase 3 3 4 6 ---------|---------|--|----- 6 [E] COG3579 Aminopeptidase C 2 3 3 8 --------------------|||----- 8 [S] COG3583 Uncharacterized protein conserved in bacteria 3 3 4 7 --------|----------|--|----- 8 [S] COG3589 Uncharacterized conserved protein 2 3 4 10 ----------------------|-|--| 18 [E] COG3591 V8-like Glu-specific endopeptidase 3 3 4 8 --------------------|-|----| 8 [R] COG3607 Predicted lactoylglutathione lyase 2 3 4 10 ----------------------|-||-- 11 [P] COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 2 3 7 10 ----------------------|-|--| 21 [K] COG3617 Prophage antirepressor 2 3 5 12 ----------------------|||--- 14 [G] COG3623 Putative L-xylulose-5-phosphate 3-epimerase 2 3 4 9 --------------|---------|--| 11 [P] COG3624 Uncharacterized enzyme of phosphonate metabolism 2 3 4 9 --------------|---------|--| 11 [P] COG3625 Uncharacterized enzyme of phosphonate metabolism 2 3 4 9 --------------|---------|--| 11 [P] COG3626 Uncharacterized enzyme of phosphonate metabolism 2 3 4 9 --------------|---------|--| 11 [P] COG3627 Uncharacterized enzyme of phosphonate metabolism 1 3 6 6 ------------------------||-| 9 [K] COG3636 Predicted transcriptional regulator 1 3 6 16 ------------------------||-| 77 [M] COG3637 Opacity protein and related surface antigens 3 3 4 6 -----------------|-|--|----- 8 [R] COG3641 Predicted membrane protein, putative toxin regulator 3 3 3 4 ----------|-----|-----|----- 4 [Q] COG3648 Uricase (urate oxidase) 2 3 4 4 --------------|---------|--| 4 [S] COG3650 Predicted membrane protein 2 3 4 5 ----------------|-------|--| 7 [S] COG3652 Predicted outer membrane protein 2 3 3 3 ----------------|-------|--| 3 [S] COG3656 Predicted periplasmic protein 1 3 4 5 ------------------------||-| 6 [C] COG3658 Cytochrome b 3 3 3 3 -------------|--------|----| 3 [G] COG3661 Alpha-glucuronidase 2 3 4 6 ----------------------|-|--| 6 [G] COG3664 Beta-xylosidase 1 3 4 4 ------------------------||-| 4 [P] COG3667 Uncharacterized protein involved in copper resistance 2 3 3 3 ---------|--------------|--| 3 [S] COG3673 Uncharacterized conserved protein 3 3 3 3 ---------|-----|--------|--- 4 [I] COG3675 Predicted lipase 2 3 3 4 ---|--------------------||-- 30 [L] COG3676 Transposase and inactivated derivatives 2 3 4 9 ---|--|---------------|----- 13 [S] COG3679 Uncharacterized conserved protein 2 3 3 5 ----------------|-------||-- 5 [S] COG3680 Uncharacterized protein conserved in bacteria 3 3 4 7 -|---------------|------|--- 7 [S] COG3681 Uncharacterized conserved protein 2 3 4 9 ----------------------|-|--| 10 [G] COG3684 Tagatose-1,6-bisphosphate aldolase 2 3 4 9 --------------|---------|--| 23 [S] COG3685 Uncharacterized protein conserved in bacteria 1 3 4 6 ------------------------||-| 6 [S] COG3692 Uncharacterized protein conserved in bacteria 3 3 5 8 -----------------|----|-|--- 9 [HI] COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) 2 3 3 8 ----------------|-------|--| 8 [S] COG3698 Predicted periplasmic protein 1 3 4 5 ------------------------||-| 7 [U] COG3701 Type IV secretory pathway, TrbF components 1 3 5 6 ------------------------||-| 24 [PT] COG3712 Fe2+-dicitrate sensor, membrane component 2 3 4 10 ----------------------|-|--| 11 [G] COG3717 5-keto 4-deoxyuronate isomerase 1 3 4 7 ------------------------||-| 7 [P] COG3720 Putative heme degradation protein 1 3 5 8 ------------------------||-| 8 [L] COG3727 DNA G:T-mismatch repair endonuclease 2 3 5 10 ----------------------|-|--| 16 [L] COG3728 Phage terminase, small subunit 2 3 4 8 ----------------------|-|--| 10 [G] COG3730 Phosphotransferase system sorbitol-specific component IIC 2 3 4 8 ----------------------|-|--| 9 [G] COG3731 Phosphotransferase system sorbitol-specific component IIA 2 3 4 7 ----------------------|-|--| 9 [G] COG3732 Phosphotransferase system sorbitol-specific component IIBC 1 3 4 8 ------------------------||-| 10 [G] COG3734 2-keto-3-deoxy-galactonokinase 1 3 4 9 ------------------------|-|| 16 [U] COG3736 Type IV secretory pathway, component VirB8 1 3 5 9 ------------------------||-| 9 [S] COG3737 Uncharacterized conserved protein 2 3 5 7 ----------------------|-|--| 7 [S] COG3739 Uncharacterized integral membrane protein 2 3 5 8 ----------------|-------|--| 13 [E] COG3741 N-formylglutamate amidohydrolase 1 3 4 6 ------------------------||-| 10 [U] COG3745 Flp pilus assembly protein CpaB 1 3 4 7 ------------------------||-| 9 [S] COG3748 Predicted membrane protein 1 3 4 7 ------------------------||-| 9 [S] COG3749 Uncharacterized protein conserved in bacteria 1 3 4 8 ------------------------||-| 11 [S] COG3753 Uncharacterized protein conserved in bacteria 2 3 4 7 ----------------------|-|--| 7 [S] COG3760 Uncharacterized conserved protein 3 3 3 7 -----|--|---------------|--- 7 [R] COG3769 Predicted hydrolase (HAD superfamily) 2 3 4 8 ---------------------||----| 17 [M] COG3773 Cell wall hydrolyses involved in spore germination 2 3 4 10 ---------------------||-|--- 17 [G] COG3775 Phosphotransferase system, galactitol-specific IIC component 1 3 3 4 ------------------------||-| 5 [S] COG3779 Uncharacterized protein conserved in bacteria 2 3 4 8 --------------|---------|--| 8 [R] COG3788 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily 1 3 4 6 ------------------------||-| 14 [S] COG3795 Uncharacterized protein conserved in bacteria 3 3 5 8 --------------------|-|----| 10 [S] COG3797 Uncharacterized protein conserved in bacteria 2 3 3 4 ---|--------------------|--| 5 [E] COG3799 Methylaspartate ammonia-lyase 1 3 4 7 ------------------------||-| 10 [S] COG3803 Uncharacterized protein conserved in bacteria 3 3 3 4 ------|-------------|------| 6 [S] COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase 2 3 3 3 --------------|---------|--| 3 [Q] COG3805 Aromatic ring-cleaving dioxygenase 1 3 4 4 ------------------------||-| 5 [T] COG3806 Anti-sigma factor 2 3 4 4 --------|-----------------|| 4 [S] COG3809 Uncharacterized protein conserved in bacteria 1 3 4 4 ------------------------||-| 4 [S] COG3812 Uncharacterized protein conserved in bacteria 1 3 4 6 ------------------------||-| 6 [S] COG3813 Uncharacterized protein conserved in bacteria 1 3 3 3 ||-|------------------------ 3 [S] COG3815 Predicted membrane protein 2 3 4 7 ----------------------|-|--| 7 [R] COG3822 ABC-type sugar transport system, auxiliary component 2 3 4 5 --------------------|----|-| 5 [S] COG3826 Uncharacterized protein conserved in bacteria 2 3 6 11 ---------------------||-|--- 11 [KT] COG3835 Sugar diacid utilization regulator 1 3 5 8 ------------------------||-| 13 [U] COG3838 Type IV secretory pathway, VirB2 components (pilins) 1 3 5 7 ------------------------||-| 16 [U] COG3847 Flp pilus assembly protein, pilin Flp 1 3 7 14 ------------------------||-| 14 [T] COG3852 Signal transduction histidine kinase, nitrogen specific 2 3 4 6 -----------------|---||----- 6 [G] COG3855 Uncharacterized protein conserved in bacteria 2 3 3 5 --------------------|||----- 5 [S] COG3856 Uncharacterized conserved protein (small basic protein) 2 3 3 4 ---------------------||-|--- 10 [R] COG3858 Predicted glycosyl hydrolase 2 3 3 3 ------|--------------||----- 3 [S] COG3863 Uncharacterized distant relative of cell wall-associated hydrolases 3 3 3 3 -------------|--|----|------ 3 [S] COG3864 Uncharacterized protein conserved in bacteria 2 3 3 4 -------------|-------||----- 6 [G] COG3866 Pectate lyase 2 3 3 7 ------------------|--||----- 7 [E] COG3869 Arginine kinase 2 3 3 6 ----------------|----||----- 7 [S] COG3870 Uncharacterized protein conserved in bacteria 2 3 3 5 ------------------|--||----- 5 [S] COG3876 Uncharacterized protein conserved in bacteria 3 3 3 3 -------------|--|----|------ 3 [S] COG3877 Uncharacterized protein conserved in bacteria 2 3 3 5 --------------------|||----- 12 [S] COG3879 Uncharacterized protein conserved in bacteria 2 3 3 7 ------------------|--||----- 7 [S] COG3880 Uncharacterized protein with conserved CXXC pairs 2 3 3 4 ----------------|----||----- 4 [S] COG3881 Uncharacterized protein conserved in bacteria 2 3 3 7 --------------------|||----- 9 [I] COG3884 Acyl-ACP thioesterase 1 3 4 9 ---------------------|||---- 9 [T] COG3887 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain 2 3 3 4 ----|-|-|------------------- 4 [K] COG3888 Predicted transcriptional regulator 1 3 4 8 ------------------------||-| 8 [S] COG3892 Uncharacterized protein conserved in bacteria 1 3 4 9 -------------------------||| 9 [L] COG3893 Inactivated superfamily I helicase 2 3 3 4 --|---|--------------------| 8 [R] COG3894 Uncharacterized metal-binding protein 1 3 4 6 ------------------------||-| 6 [K] COG3901 Regulator of nitric oxide reductase transcription 2 3 4 9 -------------|-------||----- 9 [S] COG3906 Uncharacterized protein conserved in bacteria 1 3 3 6 ------------------------||-| 6 [C] COG3909 Cytochrome c556 1 3 3 4 ------------------------||-| 4 [S] COG3913 Uncharacterized protein conserved in bacteria 2 3 4 4 --------------||-----------| 7 [O] COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family 1 3 4 6 ------------------------||-| 12 [TQ] COG3916 N-acyl-L-homoserine lactone synthetase 1 3 4 4 ------------------------||-| 5 [Q] COG3917 2-hydroxychromene-2-carboxylate isomerase 1 3 3 6 ------------------------||-| 10 [R] COG3926 Putative secretion activating protein 2 3 4 5 --------------||-----------| 7 [R] COG3932 Uncharacterized ABC-type transport system, permease components 2 3 3 4 ---------------------||-|--- 7 [K] COG3933 Transcriptional antiterminator 2 3 3 3 ---------------------||-|--- 3 [R] COG3940 Predicted beta-xylosidase 2 3 4 6 --------------------|||----- 9 [M] COG3944 Capsular polysaccharide biosynthesis protein 3 3 5 5 --------|------------|--|--- 6 [S] COG3945 Uncharacterized conserved protein 1 3 4 6 ------------------------||-| 8 [U] COG3946 Type IV secretory pathway, VirJ component 2 3 3 3 ----------------|----||----- 4 [T] COG3947 Response regulator containing CheY-like receiver and SARP domains 2 3 5 10 -------------------|----||-- 11 [MNO] COG3951 Rod binding protein 2 3 3 5 ------------------|-----|--| 5 [S] COG3952 Predicted membrane protein 2 3 4 6 --------------------|||----- 9 [R] COG3953 SLT domain proteins 2 3 3 3 ---------------------||-|--- 4 [M] COG3955 Exopolysaccharide biosynthesis protein 1 3 4 8 ------------------------||-| 8 [R] COG3960 Glyoxylate carboligase 2 3 3 6 ----------------------|-|--| 7 [I] COG3963 Phospholipid N-methyltransferase 2 3 4 5 ----------------------|-|--| 5 [P] COG3965 Predicted Co/Zn/Cd cation transporters 3 3 3 3 ---------------||----|------ 3 [R] COG3968 Uncharacterized protein related to glutamine synthetase 2 3 5 9 ----------------------|-||-- 12 [R] COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase 2 3 4 6 --------|---------------|--| 6 [R] COG3970 Fumarylacetoacetate (FAA) hydrolase family protein 3 3 3 3 -------------------|-|-----| 4 [S] COG3976 Uncharacterized protein conserved in bacteria 2 3 4 9 --------------|---------||-- 9 [E] COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase 3 3 6 8 ---|------------------|-|--- 17 [R] COG3979 Uncharacterized protein contain chitin-binding domain type 3 1 3 3 3 |-----||-------------------- 3 [R] COG4001 Predicted metal-binding protein 1 3 3 4 -----|||-------------------- 4 [S] COG4003 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 6 [R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase 1 3 3 3 ||-----|-------------------- 3 [S] COG4009 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [S] COG4010 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [S] COG4013 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family 1 3 3 3 ||-----|-------------------- 3 [S] COG4016 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [S] COG4017 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [S] COG4018 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [S] COG4019 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [S] COG4024 Uncharacterized protein conserved in archaea 1 3 3 4 |----|-|-------------------- 4 [S] COG4025 Predicted membrane protein 1 3 3 3 |----|-|-------------------- 3 [R] COG4026 Uncharacterized protein containing TOPRIM domain, potential nuclease 2 3 3 4 -----|-||------------------- 4 [S] COG4027 Uncharacterized protein conserved in archaea 2 3 4 5 -----|-||------------------- 5 [R] COG4028 Predicted P-loop ATPase/GTPase 1 3 3 3 |-----||-------------------- 3 [S] COG4030 Uncharacterized protein conserved in archaea 2 3 5 5 ------|||------------------- 5 [S] COG4034 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [S] COG4035 Predicted membrane protein 1 3 3 3 ||-----|-------------------- 3 [S] COG4036 Predicted membrane protein 1 3 3 3 ||-----|-------------------- 3 [S] COG4037 Predicted membrane protein 1 3 3 3 ||-----|-------------------- 3 [S] COG4038 Predicted membrane protein 1 3 3 3 ||-----|-------------------- 3 [S] COG4039 Predicted membrane protein 1 3 3 3 ||-----|-------------------- 3 [S] COG4040 Predicted membrane protein 1 3 3 3 ||-----|-------------------- 3 [S] COG4041 Predicted membrane protein 1 3 3 3 ||-----|-------------------- 3 [S] COG4042 Predicted membrane protein 2 3 3 4 -----|-|--------------|----- 6 [S] COG4043 Uncharacterized conserved protein 2 3 5 5 |------||------------------- 5 [S] COG4046 Uncharacterized protein conserved in archaea 2 3 4 5 -----|-||------------------- 5 [S] COG4047 Uncharacterized protein conserved in archaea 1 3 3 4 -|---|-|-------------------- 4 [R] COG4049 Uncharacterized protein containing archaeal-type C2H2 Zn-finger 1 3 3 3 ||-----|-------------------- 3 [S] COG4053 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 4 [S] COG4066 Uncharacterized protein conserved in archaea 1 3 3 3 |-----||-------------------- 3 [S] COG4068 Uncharacterized protein containing a Zn-ribbon 1 3 3 3 ||-----|-------------------- 3 [S] COG4071 Uncharacterized protein conserved in archaea 1 3 3 4 -|---|-|-------------------- 4 [S] COG4072 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase 1 3 3 3 ||-----|-------------------- 4 [S] COG4075 Uncharacterized conserved protein, homolog of nitrogen regulatory protein PII 1 3 3 3 ||-----|-------------------- 3 [R] COG4076 Predicted RNA methylase 1 3 3 3 ||-----|-------------------- 3 [S] COG4077 Uncharacterized protein conserved in archaea 1 3 3 3 ||-----|-------------------- 3 [S] COG4078 Predicted membrane protein 2 3 5 5 -|-----||------------------- 6 [L] COG4080 RecB-family nuclease 1 3 3 3 ||-----|-------------------- 3 [S] COG4084 Uncharacterized protein conserved in archaea 3 3 3 6 --------------|-------|----| 7 [E] COG4091 Predicted homoserine dehydrogenase 1 3 3 3 -------------------------||| 3 [M] COG4092 Predicted glycosyltransferase involved in capsule biosynthesis 2 3 4 5 --------------||-----------| 7 [S] COG4094 Predicted membrane protein 2 3 4 4 -------------|----------|--| 4 [R] COG4099 Predicted peptidase 1 3 3 4 ------------------------||-| 4 [G] COG4101 Predicted mannose-6-phosphate isomerase 2 3 4 9 --------------|---------|--| 11 [P] COG4107 ABC-type phosphonate transport system, ATPase component 3 3 3 5 ----------------|----|--|--- 6 [R] COG4110 Uncharacterized protein involved in stress response 2 3 3 7 ----------------------|-|--| 7 [R] COG4114 Uncharacterized Fe-S protein 2 3 3 6 ---------------------||----| 10 [G] COG4124 Beta-mannanase 1 3 4 6 ------------------------||-| 7 [S] COG4125 Predicted membrane protein 1 3 3 5 ------------------------||-| 5 [G] COG4130 Predicted sugar epimerase 1 3 3 6 ------------------------|-|| 6 [R] COG4132 ABC-type uncharacterized transport system, permease component 2 3 6 14 ----------------------|-|--| 14 [P] COG4148 ABC-type molybdate transport system, ATPase component 2 3 4 10 ----------------------|-|--| 12 [G] COG4154 Fucose dissimilation pathway protein FucU 1 3 6 12 ------------------------||-| 12 [Q] COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component 2 3 3 3 ---|--------------------|--| 6 [K] COG4190 Predicted transcriptional regulator 1 3 4 6 ------------------------||-| 14 [T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system 3 3 3 4 --------------------|-|----| 7 [R] COG4195 Phage-related replication protein 2 3 3 3 ---------------------||----| 6 [S] COG4200 Uncharacterized protein conserved in bacteria 1 3 6 10 ------------------------||-| 11 [H] COG4206 Outer membrane cobalamin receptor protein 3 3 5 10 -----------------|-|----|--- 10 [G] COG4211 ABC-type glucose/galactose transport system, permease component 2 3 3 3 ---------------------||----| 7 [KT] COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component 2 3 4 9 -----------------|---||----- 11 [S] COG4224 Uncharacterized protein conserved in bacteria 1 3 7 15 ------------------------||-| 15 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogenase 2 3 4 8 ------------------|-----|--| 8 [OC] COG4233 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis 2 3 3 3 --------------||-----------| 5 [QP] COG4242 Cyanophycinase and related exopeptidases 2 3 3 6 --------------|---------|-|- 8 [R] COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain 3 3 3 3 --------------|-------|----| 3 [I] COG4247 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) 3 3 3 5 --------------|-|-------|--- 5 [R] COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains 2 3 3 3 --------------|---------|--| 15 [R] COG4249 Uncharacterized protein containing caspase domain 2 3 3 3 ---|----------||------------ 4 [T] COG4250 Predicted sensor protein/domain 1 3 4 4 ------------------------||-| 4 [S] COG4254 Uncharacterized protein conserved in bacteria 1 3 3 7 ------------------------||-| 7 [P] COG4256 Hemin uptake protein 2 3 3 3 ---------------|--------||-- 4 [V] COG4257 Streptogramin lyase 3 3 3 5 ------------|-------|----|-- 6 [R] COG4262 Predicted spermidine synthase with an N-terminal membrane domain 1 3 3 4 ------------------------||-| 5 [C] COG4263 Nitrous oxide reductase 3 3 4 5 ----|---|-------------|----- 5 [S] COG4272 Predicted membrane protein 2 3 3 4 ----|--------------------|-| 5 [S] COG4275 Uncharacterized conserved protein 3 3 3 3 --------|-----|------------| 4 [S] COG4280 Predicted membrane protein 2 3 4 4 -------------|----------||-- 4 [R] COG4287 PhoPQ-activated pathogenicity-related protein 3 3 3 3 -------------||------------| 4 [S] COG4288 Uncharacterized protein conserved in bacteria 2 3 3 4 -------------|----------|--| 4 [S] COG4289 Uncharacterized protein conserved in bacteria 2 3 3 6 ----------------|--------|-| 6 [S] COG4291 Predicted membrane protein 3 3 3 4 --------------|-|---|------- 6 [S] COG4293 Uncharacterized protein conserved in bacteria 3 3 3 3 --------------|-|----|------ 3 [S] COG4295 Uncharacterized protein conserved in bacteria 3 3 3 3 --------------|-|----|------ 3 [S] COG4296 Uncharacterized protein conserved in bacteria 3 3 3 4 ----------------|-----|----| 4 [S] COG4297 Uncharacterized protein containing double-stranded beta helix domain 3 3 3 3 --------------|-|----------| 3 [S] COG4298 Uncharacterized protein conserved in bacteria 3 3 3 3 --------------|-|----------| 3 [S] COG4299 Uncharacterized conserved protein 2 3 3 4 ---------------------|--||-- 4 [S] COG4304 Uncharacterized protein conserved in bacteria 2 3 3 3 ----------------------|-||-- 3 [G] COG4305 Endoglucanase C-terminal domain/subunit and related proteins 2 3 3 3 ---------------------|--||-- 3 [S] COG4306 Uncharacterized protein conserved in bacteria 2 3 3 5 --------------------|----|-| 5 [S] COG4307 Uncharacterized protein conserved in bacteria 2 3 3 4 --------------------|----|-| 5 [Q] COG4308 Limonene-1,2-epoxide hydrolase 2 3 3 4 ---------------------|----|| 4 [R] COG4310 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain 1 3 3 6 ------------------------||-| 14 [E] COG4311 Sarcosine oxidase delta subunit 1 3 3 5 ------------------------||-| 10 [S] COG4312 Uncharacterized protein conserved in bacteria 1 3 3 4 ------------------------||-| 8 [C] COG4313 Protein involved in meta-pathway of phenol degradation 1 3 4 6 ------------------------||-| 6 [C] COG4314 Predicted lipoprotein involved in nitrous oxide reduction 1 3 3 4 ------------------------||-| 5 [S] COG4315 Uncharacterized protein conserved in bacteria 1 3 3 4 ------------------------||-| 4 [S] COG4316 Uncharacterized protein conserved in bacteria 1 3 3 4 ------------------------||-| 4 [S] COG4318 Uncharacterized protein conserved in bacteria 1 3 3 3 ------------------------||-| 3 [S] COG4320 Uncharacterized protein conserved in bacteria 1 3 3 6 ------------------------||-| 9 [R] COG4321 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis 1 3 3 3 ------------------------||-| 3 [S] COG4322 Uncharacterized protein conserved in bacteria 1 3 3 3 ------------------------||-| 3 [S] COG4323 Predicted membrane protein 1 3 3 3 ------------------------||-| 3 [R] COG4324 Predicted aminopeptidase 3 3 3 5 --------------|-----|---|--- 5 [S] COG4325 Predicted membrane protein 3 3 3 3 --------------|-------|-|--- 3 [R] COG4326 Sporulation control protein 3 3 3 3 --------------|-------|----| 3 [S] COG4329 Predicted membrane protein 2 3 3 4 ---------------------|--|--| 4 [S] COG4332 Uncharacterized protein conserved in bacteria 2 3 3 4 ----------------------|-|--| 4 [S] COG4333 Uncharacterized protein conserved in bacteria 2 3 3 3 ----------------------|-|--| 3 [S] COG4334 Uncharacterized protein conserved in bacteria 2 3 3 3 ----------------------|-|--| 4 [L] COG4335 DNA alkylation repair enzyme 2 3 3 3 --------------|---------|--| 3 [S] COG4337 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------|---------|--| 3 [S] COG4338 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------|---------|--| 3 [S] COG4339 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------|---------|--| 3 [S] COG4340 Uncharacterized protein conserved in bacteria 2 3 3 4 ----||--|------------------- 4 [S] COG4344 Uncharacterized protein conserved in archaea 2 3 3 3 --------|-----||------------ 6 [G] COG4354 Predicted bile acid beta-glucosidase 2 3 4 5 ---------||-----------|----- 5 [S] COG4357 Uncharacterized conserved protein 2 3 3 3 ---------|----||------------ 4 [F] COG4360 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) 2 3 3 3 --------------|||----------- 4 [S] COG4370 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------|||----------- 3 [S] COG4371 Predicted membrane protein 2 3 3 3 --------------|||----------- 3 [S] COG4372 Uncharacterized protein conserved in bacteria with the myosin-like domain 2 3 3 3 ---------------------||---|- 3 [S] COG4378 Uncharacterized protein conserved in bacteria 1 3 5 5 ------------------------||-| 7 [R] COG4385 Bacteriophage P2-related tail formation protein 1 3 6 9 ------------------------||-| 9 [S] COG4391 Uncharacterized protein conserved in bacteria 2 3 4 4 -----------------|------|-|- 4 [S] COG4393 Predicted membrane protein 2 3 4 4 -----------------|------||-- 4 [S] COG4394 Uncharacterized protein conserved in bacteria 1 3 6 10 ------------------------||-| 14 [S] COG4395 Uncharacterized protein conserved in bacteria 2 3 3 4 --------------||----|------- 6 [S] COG4398 Uncharacterized protein conserved in bacteria 2 3 3 5 --------------||------|----- 5 [E] COG4401 Chorismate mutase 2 3 3 4 --------------||----|------- 4 [S] COG4402 Uncharacterized protein conserved in bacteria 2 3 4 5 --------------|------||----- 7 [V] COG4403 Lantibiotic modifying enzyme 2 3 4 9 ---------------------||-|--- 9 [S] COG4405 Uncharacterized protein conserved in bacteria 3 3 5 5 --------------------|-|-|--- 7 [G] COG4409 Neuraminidase (sialidase) 2 3 3 3 ---------------------||-|--- 3 [S] COG4412 Uncharacterized protein conserved in bacteria 2 3 4 4 ----------------------|-|--| 4 [E] COG4413 Urea transporter 3 3 4 8 --------------|-------|----| 8 [S] COG4430 Uncharacterized protein conserved in bacteria 2 3 4 6 -------------------|-||----- 6 [S] COG4443 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------||--------|--- 4 [S] COG4446 Uncharacterized protein conserved in bacteria 2 3 3 6 --------------||-----------| 6 [E] COG4448 L-asparaginase II 2 3 3 3 --------------||-----------| 3 [R] COG4449 Predicted protease of the Abi (CAAX) family 2 3 3 3 --------------||-----------| 6 [C] COG4451 Ribulose bisphosphate carboxylase small subunit 2 3 4 8 -----------------|------|--| 8 [V] COG4452 Inner membrane protein involved in colicin E2 resistance 2 3 6 7 ---------------|--------|--| 12 [S] COG4456 Virulence-associated protein and related proteins 2 3 4 7 --------------------|---|--| 8 [S] COG4461 Uncharacterized protein conserved in bacteria, putative lipoprotein 2 3 4 6 -----------------|---||----- 7 [G] COG4468 Galactose-1-phosphate uridyltransferase 1 3 3 5 ---------------------|||---- 5 [S] COG4478 Predicted membrane protein 2 3 3 5 -----------------|---||----- 5 [R] COG4492 ACT domain-containing protein 2 3 3 6 ---------------------||-|--- 6 [S] COG4496 Uncharacterized protein conserved in bacteria 1 3 3 3 ---------------------|||---- 3 [S] COG4508 Uncharacterized protein conserved in bacteria 3 3 4 10 ----------------|-----|-|--- 18 [R] COG4533 ABC-type uncharacterized transport system, periplasmic component 3 3 3 4 -----------------|-|----|--- 4 [O] COG4545 Glutaredoxin-related protein 2 3 3 6 ----------------------|-|--| 6 [P] COG4548 Nitric oxide reductase activation protein 1 3 3 4 ------------------------||-| 4 [T] COG4564 Signal transduction histidine kinase 3 3 5 9 --------------------|-|-|--- 19 [KT] COG4565 Response regulator of citrate/malate metabolism 1 3 6 9 ------------------------||-| 18 [T] COG4566 Response regulator 1 3 5 8 ------------------------||-| 10 [TK] COG4567 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain 2 3 3 6 --------------------|---||-- 6 [Q] COG4569 Acetaldehyde dehydrogenase (acetylating) 3 3 4 9 ------------|---------|-|--- 22 [L] COG4570 Holliday junction resolvase 2 3 3 6 --------------|---------|--| 7 [R] COG4572 Putative cation transport regulator 1 3 3 9 ------------------------||-| 12 [G] COG4573 Predicted tagatose 6-phosphate kinase 1 3 3 6 ------------------------||-| 13 [E] COG4583 Sarcosine oxidase gamma subunit 1 3 4 5 ------------------------|-|| 6 [R] COG4588 Accessory colonization factor AcfC, contains ABC-type periplasmic domain 2 3 6 9 -----------------|------|--| 9 [R] COG4589 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase 2 3 4 9 --------------|---------|--| 9 [E] COG4597 ABC-type amino acid transport system, permease component 1 3 4 7 ------------------------|||- 7 [QP] COG4615 ABC-type siderophore export system, fused ATPase and permease components 2 3 6 9 ------------|-----------|--| 18 [R] COG4618 ABC-type protease/lipase transport system, ATPase and permease components 2 3 3 6 ----------------------|-||-- 6 [R] COG4619 ABC-type uncharacterized transport system, ATPase component 2 3 3 3 --------------|------||----- 4 [S] COG4633 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------||--------|--- 7 [S] COG4634 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------|---------|--| 5 [R] COG4637 Predicted ATPase 2 3 3 4 ---------------------||----| 8 [S] COG4641 Uncharacterized protein conserved in bacteria 1 3 6 12 ------------------------||-| 12 [P] COG4651 Kef-type K+ transport system, predicted NAD-binding component 2 3 3 3 ------------|-----------||-- 5 [C] COG4654 Cytochrome c551/c552 1 3 3 5 ------------------------||-| 5 [S] COG4655 Predicted membrane protein 2 3 3 5 --------------||-----------| 10 [R] COG4671 Predicted glycosyl transferase 2 3 3 3 --------------|----------|-| 7 [S] COG4675 Microcystin-dependent protein 2 3 3 7 ---------------------|--||-- 7 [G] COG4677 Pectin methylesterase 3 3 5 8 --------------|-------|-|--- 11 [S] COG4679 Phage-related protein 2 3 3 7 --------------|---------|--| 7 [S] COG4680 Uncharacterized protein conserved in bacteria 2 3 3 7 ----------------------|-||-- 10 [S] COG4682 Predicted membrane protein 3 3 3 4 --------------|-----|---|--- 6 [S] COG4683 Uncharacterized protein conserved in bacteria 2 3 3 3 ---------------------|---|-| 5 [Q] COG4689 Acetoacetate decarboxylase 3 3 4 5 --|-------------------|-|--- 7 [E] COG4690 Dipeptidase 2 3 3 4 --------------------|---|--| 5 [R] COG4691 Plasmid stability protein 1 3 3 5 ------------------------|-|| 5 [G] COG4692 Predicted neuraminidase (sialidase) 1 3 3 4 ------------------------|||- 4 [S] COG4694 Uncharacterized protein conserved in bacteria 1 3 3 4 ------------------------||-| 4 [S] COG4700 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats 2 3 3 3 --------------|----------|-| 4 [S] COG4704 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------|----------|-| 4 [S] COG4705 Uncharacterized membrane-anchored protein conserved in bacteria 2 3 4 6 ---------------------||----| 6 [S] COG4709 Predicted membrane protein 1 3 3 3 ------------------------|-|| 3 [R] COG4710 Predicted DNA-binding protein with an HTH domain 2 3 3 3 ----------------|----||----- 3 [S] COG4712 Uncharacterized protein conserved in bacteria 3 3 3 5 --|-------------------|----| 5 [S] COG4717 Uncharacterized conserved protein 3 3 3 3 --------------|-|----------| 3 [S] COG4719 Uncharacterized protein conserved in bacteria 2 3 4 7 -----|---------------||----- 10 [S] COG4720 Predicted membrane protein 3 3 3 3 ---------|----|------------| 3 [TK] COG4725 Transcriptional activator, adenine-specific DNA methyltransferase 2 3 3 3 ---------------------|--||-- 3 [S] COG4728 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------|---------|--| 3 [R] COG4734 Antirestriction protein 1 3 3 4 --|-|-|--------------------- 7 [K] COG4738 Predicted transcriptional regulator 1 3 3 3 --|---||-------------------- 4 [S] COG4739 Uncharacterized protein containing a ferredoxin domain 1 3 3 3 |-|----|-------------------- 3 [R] COG4740 Predicted metalloprotease 1 3 3 3 |-|---|--------------------- 31 [K] COG4742 Predicted transcriptional regulator 1 3 3 4 |-|--|---------------------- 4 [S] COG4743 Predicted membrane protein 1 3 3 3 --||--|--------------------- 5 [O] COG4745 Predicted membrane-bound mannosyltransferase 1 3 3 3 |-|---|--------------------- 4 [R] COG4747 ACT domain-containing protein 1 3 3 3 --||--|--------------------- 3 [S] COG4749 Uncharacterized protein conserved in archaea 3 3 3 3 ------------||---|---------- 3 [S] COG4752 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------||----|------- 9 [O] COG4759 Uncharacterized protein conserved in bacteria containing thioredoxin-like domain 2 3 3 5 --------------------|---|--| 5 [S] COG4763 Predicted membrane protein 2 3 4 6 --------------------|||----- 15 [V] COG4767 Glycopeptide antibiotics resistance protein 1 3 5 9 ------------------------|-|| 19 [P] COG4771 Outer membrane receptor for ferrienterochelin and colicins 1 3 5 6 ------------------------|-|| 11 [P] COG4772 Outer membrane receptor for Fe3+-dicitrate 2 3 4 9 --------------|---------|--| 11 [P] COG4778 ABC-type phosphonate transport system, ATPase component 2 3 5 9 --------------------|---|--| 10 [P] COG4779 ABC-type enterobactin transport system, permease component 2 3 3 6 --------------|----------|-| 12 [S] COG4782 Uncharacterized protein conserved in bacteria 1 3 4 7 ------------------------||-| 11 [U] COG4790 Type III secretory pathway, component EscR 1 3 7 12 ------------------------||-| 16 [U] COG4795 Type II secretory pathway, component PulJ 1 3 3 3 -||---|--------------------- 3 [K] COG4800 Predicted transcriptional regulator with an HTH domain 3 3 3 6 --|------------|-----------| 9 [S] COG4803 Predicted membrane protein 2 3 3 3 --------------------|---|--| 8 [S] COG4805 Uncharacterized protein conserved in bacteria 1 3 3 4 -||--|---------------------- 7 [G] COG4809 Archaeal ADP-dependent phosphofructokinase/glucokinase 3 3 3 6 -----------------|----|-|--- 7 [E] COG4810 Ethanolamine utilization protein 3 3 3 6 -----------------|----|-|--- 6 [E] COG4812 Ethanolamine utilization cobalamin adenosyltransferase 3 3 3 6 -----------------|----|-|--- 8 [E] COG4816 Ethanolamine utilization protein 1 3 3 3 -||---|--------------------- 6 [S] COG4818 Predicted membrane protein 3 3 3 6 -----------------|----|-|--- 6 [E] COG4819 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition 3 3 3 6 -----------------|----|-|--- 6 [E] COG4820 Ethanolamine utilization protein, possible chaperonin 3 3 3 3 -----------------|----|-|--- 5 [V] COG4823 Abortive infection bacteriophage resistance protein 3 3 3 3 --|-----|-----|------------- 5 [O] COG4826 Serine protease inhibitor 1 3 3 3 |-|----|-------------------- 5 [R] COG4827 Predicted transporter 3 3 3 3 --|------------||----------- 5 [S] COG4828 Predicted membrane protein 3 3 3 3 --|-----|---|--------------- 4 [S] COG4831 Uncharacterized conserved protein 3 3 4 4 --|--------------|----|----- 4 [S] COG4832 Uncharacterized conserved protein 2 3 3 3 ----------------------|-|--| 4 [S] COG4834 Uncharacterized protein conserved in bacteria 2 3 3 9 --------------------|||----- 32 [S] COG4842 Uncharacterized protein conserved in bacteria 1 3 3 3 --|--||--------------------- 4 [S] COG4854 Predicted membrane protein 1 3 3 3 |-|---|--------------------- 4 [S] COG4855 Uncharacterized protein conserved in archaea 3 3 3 4 -----------------|----|----| 4 [R] COG4857 Predicted kinase 2 3 3 4 -----------------|------||-- 4 [S] COG4859 Uncharacterized protein conserved in bacteria 1 3 3 4 --|-|-|--------------------- 4 [S] COG4860 Uncharacterized protein conserved in archaea 3 3 3 4 ---|-------------|------|--- 4 [E] COG4865 Glutamate mutase epsilon subunit 3 3 3 4 -----------------|--|-|----- 4 [S] COG4868 Uncharacterized protein conserved in bacteria 3 3 3 3 -------------|--------|-|--- 4 [Q] COG4869 Propanediol utilization protein 1 3 3 3 |-|---|--------------------- 4 [S] COG4871 Uncharacterized protein conserved in archaea 3 3 3 4 --|-----------|------------| 4 [S] COG4872 Predicted membrane protein 2 3 3 3 -----------------|------||-- 3 [S] COG4874 Uncharacterized protein conserved in bacteria containing a pentein-type domain 1 3 3 3 ------------------------||-| 3 [S] COG4875 Uncharacterized protein conserved in bacteria with a cystatin-like fold 3 3 3 3 --------------------|-|----| 3 [S] COG4877 Uncharacterized protein conserved in bacteria 3 3 3 3 -------------|---|---|------ 4 [S] COG4878 Uncharacterized protein conserved in bacteria 2 3 3 3 -|----|-|------------------- 3 [R] COG4880 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats 1 3 3 3 |-|---|--------------------- 3 [S] COG4883 Uncharacterized protein conserved in archaea 3 3 3 3 -----------------|----|-|--- 3 [S] COG4884 Uncharacterized protein conserved in bacteria 1 3 3 3 --||--|--------------------- 3 [S] COG4885 Uncharacterized protein conserved in archaea 1 3 3 3 -||----|-------------------- 3 [R] COG4887 Uncharacterized metal-binding protein conserved in archaea 3 3 3 6 --------------------|-|---|- 8 [R] COG4889 Predicted helicase 2 3 3 3 |-|------------------|------ 3 [R] COG4892 Predicted heme/steroid binding protein 3 3 4 4 --|-----------------|-|----- 4 [S] COG4894 Uncharacterized conserved protein 3 3 3 3 --|-------------|-----|----- 3 [S] COG4895 Uncharacterized conserved protein 2 3 3 3 --------------------|----|-| 3 [S] COG4899 Uncharacterized protein conserved in bacteria 1 3 3 3 -||--|---------------------- 3 [S] COG4902 Uncharacterized protein conserved in archaea 1 3 3 3 |-|--|---------------------- 3 [S] COG4906 Predicted membrane protein 2 3 3 3 -||--------------|---------- 3 [S] COG4907 Predicted membrane protein 2 3 3 3 ----------------------|-|--| 3 [Q] COG4909 Propanediol dehydratase, large subunit 2 3 3 3 ----------------------|-|--| 3 [Q] COG4910 Propanediol dehydratase, small subunit 2 3 3 3 ---------------|---------|-| 3 [S] COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain 3 3 3 6 -----------------|----|-|--- 9 [E] COG4917 Ethanolamine utilization protein 1 3 3 3 -||----|-------------------- 3 [S] COG4921 Uncharacterized protein conserved in archaea 3 3 3 3 --|----------|-------------| 3 [S] COG4923 Uncharacterized conserved protein 2 3 3 3 --|---------------------||-- 3 [S] COG4925 Uncharacterized conserved protein 3 3 3 3 -----------------|----|----| 3 [R] COG4927 Predicted choloylglycine hydrolase 3 3 3 3 --|-----|---------------|--- 3 [O] COG4930 Predicted ATP-dependent Lon-type protease 3 3 3 4 ----|---|------------|------ 12 [O] COG4934 Predicted protease 2 3 3 3 ---------------------||-|--- 3 [TK] COG4936 Predicted sensor domain 1 3 3 3 |||------------------------- 3 [J] COG4937 Predicted regulatory domain of prephenate dehydrogenase 3 3 3 3 --------|-------------|-|--- 3 [S] COG4938 Uncharacterized conserved protein 3 3 3 3 -----------------|-|--|----- 3 [S] COG4939 Major membrane immunogen, membrane-anchored lipoprotein 1 3 4 5 ------------------------||-| 9 [K] COG4941 Predicted RNA polymerase sigma factor containing a TPR repeat domain 2 3 3 3 ----||--|------------------- 4 [G] COG4945 Membrane-anchored protein predicted to be involved in regulation of amylopullulanase 3 3 3 4 --------------------|-|-|--- 5 [S] COG4951 Uncharacterized protein conserved in bacteria 1 3 3 4 ------------------------||-| 5 [OU] COG4959 Type IV secretory pathway, protease TraF 1 3 6 8 ------------------------||-| 10 [OU] COG4960 Flp pilus assembly protein, protease CpaA 1 3 6 8 ------------------------||-| 27 [U] COG4961 Flp pilus assembly protein TadG 1 3 6 8 ------------------------||-| 12 [U] COG4963 Flp pilus assembly protein, ATPase CpaE 2 3 8 14 ------------|-----------||-- 41 [NU] COG4969 Tfp pilus assembly protein, major pilin PilA 1 3 6 7 ------------------------||-| 14 [NU] COG4970 Tfp pilus assembly protein FimT 1 3 5 9 ------------------------||-| 45 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain 2 3 3 6 ---------||---------|------- 7 [I] COG4981 Enoyl reductase domain of yeast-type FAS1 2 3 3 6 ---------||---------|------- 7 [I] COG4982 3-oxoacyl-[acyl-carrier protein] reductase 2 3 7 16 ----------------------|-|--| 16 [CO] COG4987 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components 2 3 3 6 ---------------------||----| 12 [S] COG4991 Uncharacterized protein with a bacterial SH3 domain homologue 2 3 3 3 ---------------------||--|-- 3 [S] COG4994 Uncharacterized protein conserved in bacteria 2 3 3 3 --------------||-----------| 17 [S] COG4995 Uncharacterized protein conserved in bacteria 2 3 6 11 ------------|------------|-| 11 [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation 1 3 6 8 ------------------------||-| 11 [U] COG5010 Flp pilus assembly protein TadD, contains TPR repeats 3 3 3 3 -------||----|-------------- 3 [R] COG5014 Predicted Fe-S oxidoreductase 3 3 3 3 ----------|-----------|-|--- 3 [R] COG5018 Inhibitor of the KinA pathway to sporulation, predicted exonuclease 2 3 3 3 ---------|||---------------- 17 [DZ] COG5019 Septin family protein 2 3 3 3 ---------|||---------------- 16 [G] COG5020 Mannosyltransferase 2 3 3 3 ---------|||---------------- 14 [O] COG5021 Ubiquitin-protein ligase 2 3 3 3 ---------|||---------------- 12 [Z] COG5022 Myosin heavy chain 2 3 3 3 ---------|||---------------- 11 [Z] COG5023 Tubulin 2 3 3 3 ---------|||---------------- 16 [D] COG5024 Cyclin 2 3 3 3 ---------|||---------------- 10 [K] COG5025 Transcription factor of the Forkhead/HNF3 family 2 3 3 3 ---------|||---------------- 7 [B] COG5027 Histone acetyltransferase (MYST family) 2 3 3 3 ---------|||---------------- 7 [U] COG5028 Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 2 3 3 3 ---------|||---------------- 7 [O] COG5029 Prenyltransferase, beta subunit 2 3 3 3 ---------|||---------------- 7 [U] COG5030 Clathrin adaptor complex, small subunit 2 3 3 3 ---------||---|------------- 6 [H] COG5031 Uncharacterized protein involved in ubiquinone biosynthesis 2 3 3 3 ---------|||---------------- 22 [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family 2 3 3 3 ---------|||---------------- 6 [K] COG5033 Transcription initiation factor IIF, auxiliary subunit 2 3 3 3 ---------|||---------------- 6 [B] COG5034 Chromatin remodeling protein, contains PhD zinc finger 2 3 3 3 ---------|||---------------- 6 [DKT] COG5035 Cell cycle control protein 2 3 3 3 ---------|||---------------- 6 [P] COG5036 SPX domain-containing protein involved in vacuolar polyphosphate accumulation 2 3 3 3 ---------|||---------------- 6 [TG] COG5037 Gluconate transport-inducing protein 2 3 3 3 ---------|||---------------- 7 [R] COG5038 Ca2+-dependent lipid-binding protein, contains C2 domain 3 3 3 3 ----------|---|-------|----- 6 [GM] COG5039 Exopolysaccharide biosynthesis protein 2 3 3 3 ---------|||---------------- 5 [T] COG5040 14-3-3 family protein 2 3 3 3 ---------|||---------------- 5 [TDK] COG5041 Casein kinase II, beta subunit 2 3 4 4 ----------|--------------|-| 5 [F] COG5042 Purine nucleoside permease 2 3 3 3 ---------|||---------------- 5 [U] COG5043 Vacuolar protein sorting-associated protein 2 3 3 3 ---------|||---------------- 6 [O] COG5044 RAB proteins geranylgeranyltransferase component A (RAB escort protein) 2 3 3 3 ---------|||---------------- 5 [J] COG5045 Ribosomal protein S10E 2 3 3 3 ---------|||---------------- 5 [O] COG5046 Protein involved in Mod5 protein sorting 2 3 3 3 ---------|||---------------- 5 [U] COG5047 Vesicle coat complex COPII, subunit SEC23 2 3 3 3 ---------|||---------------- 48 [R] COG5048 FOG: Zn-finger 2 3 3 3 ---------|||---------------- 5 [LDA] COG5049 5'-3' exonuclease 2 3 3 3 ---------|||---------------- 5 [J] COG5051 Ribosomal protein L36E 2 3 3 3 ---------|||---------------- 5 [U] COG5052 Protein involved in membrane traffic 2 3 3 3 ---------|||---------------- 5 [J] COG5053 Translation initiation factor 4E (eIF-4E) 2 3 3 3 ---------|||---------------- 5 [O] COG5054 Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins 2 3 3 3 ---------|||---------------- 5 [L] COG5055 Recombination DNA repair protein (RAD52 pathway) 2 3 3 3 ---------|||---------------- 5 [I] COG5056 Acyl-CoA cholesterol acyltransferase 2 3 3 3 ---------|||---------------- 5 [DT] COG5057 Phosphotyrosyl phosphatase activator 2 3 3 3 ---------|||---------------- 5 [U] COG5058 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor 2 3 3 3 ---------|||---------------- 22 [Z] COG5059 Kinesin-like protein 2 3 3 3 ---------|||---------------- 4 [OU] COG5061 Oxidoreductin, endoplasmic reticulum membrane-associated protein involved in disulfide bond formation 2 3 3 3 ---------|||---------------- 4 [S] COG5062 Uncharacterized membrane protein 2 3 3 3 ---------|||---------------- 4 [R] COG5063 CCCH-type Zn-finger protein 2 3 3 3 ---------|||---------------- 4 [U] COG5064 Karyopherin (importin) alpha 2 3 3 3 ---------|||---------------- 4 [P] COG5065 Protein involved in inorganic phosphate transport 2 3 3 3 ---------|||---------------- 4 [U] COG5066 VAMP-associated protein involved in inositol metabolism 2 3 3 3 ---------|||---------------- 4 [LD] COG5067 Protein kinase essential for the initiation of DNA replication 2 3 3 3 ---------|||---------------- 8 [K] COG5068 Regulator of arginine metabolism and related MADS box-containing transcription factors 2 3 3 3 ---------|||---------------- 4 [Z] COG5069 Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) 2 3 3 3 ---------|||---------------- 5 [GOU] COG5070 Nucleotide-sugar transporter 2 3 3 3 ---------|||---------------- 4 [O] COG5071 26S proteasome regulatory complex component 2 3 3 3 ---------|||---------------- 4 [D] COG5072 Serine/threonine kinase of the haspin family 2 3 3 3 ---------|||---------------- 5 [U] COG5073 Vacuolar import and degradation protein 2 3 3 3 ---------|||---------------- 4 [U] COG5074 t-SNARE complex subunit, syntaxin 2 3 3 3 ---------|||---------------- 4 [S] COG5075 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 21 [BK] COG5076 Transcription factor involved in chromatin remodeling, contains bromodomain 2 3 3 3 ---------|||---------------- 4 [O] COG5077 Ubiquitin carboxyl-terminal hydrolase 2 3 3 3 ---------|||---------------- 36 [O] COG5078 Ubiquitin-protein ligase 2 3 3 3 ---------|||---------------- 4 [UD] COG5079 Nuclear protein export factor 2 3 3 3 ---------|||---------------- 5 [U] COG5080 Rab GTPase interacting factor, Golgi membrane protein 2 3 3 3 ---------|||---------------- 4 [S] COG5081 Predicted membrane protein 2 3 3 3 ---------|||---------------- 9 [OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger 2 3 3 3 ---------|||---------------- 10 [R] COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins 2 3 3 3 ---------|||---------------- 4 [S] COG5085 Predicted membrane protein 2 3 3 3 ---------|||---------------- 3 [S] COG5086 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [S] COG5087 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [R] COG5088 Rad5p-binding protein 2 3 3 3 ---------|||---------------- 3 [K] COG5090 Transcription initiation factor IIF, small subunit (RAP30) 2 3 3 3 ---------|||---------------- 3 [R] COG5091 Suppressor of G2 allele of skp1 and related proteins 2 3 3 3 ---------|||---------------- 3 [I] COG5092 N-myristoyl transferase 2 3 3 3 ---------|||---------------- 3 [S] COG5093 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [K] COG5094 Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) 2 3 3 3 ---------|||---------------- 3 [K] COG5095 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) 2 3 3 3 ---------|||---------------- 10 [U] COG5096 Vesicle coat complex, various subunits 2 3 3 3 ---------|||---------------- 3 [K] COG5097 RNA polymerase II transcriptional regulation mediator 2 3 3 3 ---------|||---------------- 3 [BD] COG5098 Chromosome condensation complex Condensin, subunit D2 2 3 3 3 ---------|||---------------- 13 [J] COG5099 RNA-binding protein of the Puf family, translational repressor 2 3 3 3 ---------|||---------------- 3 [U] COG5100 Nuclear pore protein 2 3 3 3 ---------|||---------------- 6 [U] COG5101 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) 2 3 3 3 ---------|||---------------- 3 [U] COG5102 Membrane protein involved in ER to Golgi transport 2 3 3 3 ---------|||---------------- 3 [DK] COG5103 Cell division control protein, negative regulator of transcription 2 3 3 3 ---------|||---------------- 3 [A] COG5104 Splicing factor 2 3 3 3 ---------|||---------------- 3 [D] COG5105 Mitotic inducer, protein phosphatase 2 3 3 3 ---------|||---------------- 3 [S] COG5106 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [A] COG5107 Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor 2 3 3 3 ---------||----------------| 3 [K] COG5108 Mitochondrial DNA-directed RNA polymerase 2 3 3 3 ---------|||---------------- 3 [R] COG5109 Uncharacterized conserved protein, contains RING Zn-finger 2 3 3 3 ---------|||---------------- 3 [O] COG5110 26S proteasome regulatory complex component 2 3 3 3 ---------|||---------------- 3 [K] COG5111 DNA-directed RNA polymerase III, subunit C34 2 3 3 3 ---------|||---------------- 3 [R] COG5112 U1-like Zn-finger-containing protein 2 3 3 3 ---------|||---------------- 3 [O] COG5113 Ubiquitin fusion degradation protein 2 2 3 3 3 ---------|||---------------- 3 [B] COG5114 Histone acetyltransferase complex SAGA/ADA, subunit ADA2 2 3 3 3 ---------|||---------------- 3 [O] COG5116 26S proteasome regulatory complex component 2 3 3 3 ---------|||---------------- 3 [JU] COG5117 Protein involved in the nuclear export of pre-ribosomes 2 3 3 3 ---------|||---------------- 3 [K] COG5118 Transcription initiation factor TFIIIB, Bdp1 subunit 2 3 3 3 ---------||---|------------- 3 [R] COG5119 Uncharacterized protein, contains ParB-like nuclease domain 2 3 3 3 ---------|||---------------- 3 [U] COG5120 Membrane protein involved in Golgi transport 2 3 3 3 ---------|||---------------- 3 [U] COG5122 Transport protein particle (TRAPP) complex subunit 2 3 3 3 ---------|||---------------- 3 [K] COG5123 Transcription initiation factor IIA, gamma subunit 2 3 3 3 ---------|||---------------- 3 [DR] COG5124 Protein predicted to be involved in meiotic recombination 2 3 3 3 ---------|||---------------- 3 [S] COG5125 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [C] COG5127 Vacuolar H+-ATPase V1 sector, subunit C 2 3 3 3 ---------|||---------------- 3 [U] COG5128 Transport protein particle (TRAPP) complex subunit 2 3 3 3 ---------|||---------------- 3 [R] COG5129 Nuclear protein with HMG-like acidic region 2 3 3 3 ---------|||---------------- 3 [UT] COG5130 Prenylated rab acceptor 1 and related proteins 2 3 3 3 ---------|||---------------- 3 [KD] COG5132 Cell cycle control protein, G10 family 2 3 3 3 ---------|||---------------- 3 [S] COG5133 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [S] COG5134 Uncharacterized conserved protein 2 3 3 3 ---------||---|------------- 3 [S] COG5135 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [A] COG5136 U1 snRNP-specific protein C 2 3 3 3 ---------|||---------------- 3 [KB] COG5137 Histone chaperone involved in gene silencing 2 3 3 3 ---------|||---------------- 3 [S] COG5138 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [S] COG5139 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [O] COG5140 Ubiquitin fusion-degradation protein 2 3 3 3 ---------|||---------------- 3 [R] COG5141 PHD zinc finger-containing protein 2 3 3 3 ---------|||---------------- 3 [L] COG5142 Oxidation resistance protein 2 3 3 3 ---------|||---------------- 10 [U] COG5143 Synaptobrevin/VAMP-like protein 2 3 3 3 ---------|||---------------- 3 [KL] COG5144 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2 2 3 3 3 ---------|||---------------- 3 [L] COG5145 DNA excision repair protein 2 3 3 3 ---------||-----------|----- 3 [H] COG5146 Pantothenate kinase, acetyl-CoA regulated 2 3 3 3 ---------|||---------------- 10 [KAD] COG5147 Myb superfamily proteins, including transcription factors and mRNA splicing factors 2 3 3 3 ---------|||---------------- 3 [O] COG5148 26S proteasome regulatory complex, subunit RPN10/PSMD4 2 3 3 3 ---------|||---------------- 3 [K] COG5149 Transcription initiation factor IIA, large chain 2 3 3 3 ---------|||---------------- 3 [K] COG5150 Class 2 transcription repressor NC2, beta subunit (Dr1) 2 3 3 3 ---------|||---------------- 3 [KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 2 3 3 3 ---------|||---------------- 3 [R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers 2 3 3 3 ---------|||---------------- 3 [UI] COG5153 Putative lipase essential for disintegration of autophagic bodies inside the vacuole 2 3 3 3 ---------|||---------------- 3 [J] COG5154 RNA-binding protein required for 60S ribosomal subunit biogenesis 2 3 3 3 ---------|||---------------- 3 [DO] COG5155 Separase, a protease involved in sister chromatid separation 2 3 3 3 ---------|||---------------- 3 [DO] COG5156 Anaphase-promoting complex (APC), subunit 10 2 3 3 3 ---------|||---------------- 3 [K] COG5157 RNA polymerase II assessory factor 2 3 3 3 ---------|||---------------- 11 [U] COG5158 Proteins involved in synaptic transmission and general secretion, Sec1 family 2 3 3 3 ---------|||---------------- 3 [O] COG5159 26S proteasome regulatory complex component 2 3 3 3 ---------|||---------------- 5 [O] COG5160 Protease, Ulp1 family 2 3 3 3 ---------|||---------------- 3 [A] COG5161 Pre-mRNA cleavage and polyadenylation specificity factor 2 3 3 3 ---------|||---------------- 3 [K] COG5162 Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA) 2 3 3 3 ---------|||---------------- 3 [J] COG5163 Protein required for biogenesis of the 60S ribosomal subunit 2 3 3 3 ---------|||---------------- 3 [K] COG5164 Transcription elongation factor 2 3 3 3 ---------|||---------------- 3 [KLB] COG5165 Nucleosome-binding factor SPN, POB3 subunit 2 3 3 3 ---------|||---------------- 3 [S] COG5166 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [U] COG5167 Protein involved in vacuole import and degradation 2 3 3 3 ---------|||---------------- 10 [K] COG5169 Heat shock transcription factor 2 3 3 3 ---------|||---------------- 3 [T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit 2 3 3 3 ---------|||---------------- 3 [U] COG5171 Ran GTPase-activating protein (Ran-binding protein) 2 3 3 3 ---------|||---------------- 3 [U] COG5173 Exocyst complex subunit SEC6 2 3 3 3 ---------|||---------------- 3 [K] COG5174 Transcription initiation factor IIE, beta subunit 2 3 3 3 ---------|||---------------- 3 [K] COG5175 Transcriptional repressor 2 3 3 3 ---------|||---------------- 3 [A] COG5176 Splicing factor (branch point binding protein) 2 3 3 3 ---------|||---------------- 3 [S] COG5177 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [A] COG5178 U5 snRNP spliceosome subunit 2 3 3 3 ---------|||---------------- 3 [K] COG5179 Transcription initiation factor TFIID, subunit TAF1 2 3 3 3 ---------|||---------------- 3 [A] COG5180 Protein interacting with poly(A)-binding protein 2 3 3 3 ---------|||---------------- 3 [A] COG5181 U2 snRNP spliceosome subunit 2 3 3 3 ---------|||---------------- 3 [A] COG5182 Splicing factor 3b, subunit 2 2 3 3 3 ---------|||---------------- 3 [A] COG5183 Protein involved in mRNA turnover and stability 2 3 3 3 ---------|||---------------- 3 [D] COG5185 Protein involved in chromosome segregation, interacts with SMC proteins 2 3 3 3 ---------|||---------------- 3 [A] COG5186 Poly(A) polymerase 2 3 3 3 ---------|||---------------- 3 [O] COG5187 26S proteasome regulatory complex component, contains PCI domain 2 3 3 3 ---------|||---------------- 3 [A] COG5188 Splicing factor 3a, subunit 3 2 3 3 3 ---------|||---------------- 3 [KD] COG5189 Putative transcriptional repressor regulating G2/M transition 2 3 3 3 ---------|||---------------- 12 [K] COG5190 TFIIF-interacting CTD phosphatases, including NLI-interacting factor 2 3 3 3 ---------|||---------------- 3 [R] COG5191 Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat 2 3 3 3 ---------|||---------------- 3 [J] COG5192 GTP-binding protein required for 40S ribosome biogenesis 2 3 3 3 ---------|||---------------- 6 [OJ] COG5193 La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation 2 3 3 3 ---------|||---------------- 5 [OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex 2 3 3 3 ---------|||---------------- 3 [S] COG5195 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [U] COG5196 ER lumen protein retaining receptor 2 3 3 3 ---------|||---------------- 3 [S] COG5197 Predicted membrane protein 2 3 3 3 ---------|||---------------- 3 [R] COG5198 Protein tyrosine phosphatase-like protein (contains Pro instead of catalytic Arg) 2 3 3 3 ---------|||---------------- 3 [Z] COG5199 Calponin 2 3 3 3 ---------|||---------------- 3 [A] COG5200 U1 snRNP component, mediates U1 snRNP association with cap-binding complex 2 3 3 3 ---------|||---------------- 3 [O] COG5201 SCF ubiquitin ligase, SKP1 component 2 3 3 3 ---------|||---------------- 3 [S] COG5202 Predicted membrane protein 2 3 3 3 ---------|||---------------- 3 [K] COG5204 Transcription elongation factor SPT4 2 3 3 3 ---------|||---------------- 3 [O] COG5206 Glycosylphosphatidylinositol transamidase (GPIT), subunit GPI8 2 3 3 3 ---------|||---------------- 3 [O] COG5207 Isopeptidase T 2 3 3 3 ---------|||---------------- 3 [K] COG5208 CCAAT-binding factor, subunit C 2 3 3 3 ---------|||---------------- 3 [R] COG5209 Uncharacterized protein involved in cell differentiation/sexual development 2 3 3 3 ---------|||---------------- 25 [R] COG5210 GTPase-activating protein 2 3 3 3 ---------|||---------------- 3 [K] COG5211 RNA polymerase II-interacting protein involved in transcription start site selection 2 3 3 3 ---------||-------------|--- 3 [T] COG5212 Low-affinity cAMP phosphodiesterase 2 3 3 3 ---------|||---------------- 3 [A] COG5213 Polyadenylation factor I complex, subunit FIP1 2 3 3 3 ---------|||---------------- 3 [L] COG5214 DNA polymerase alpha-primase complex, polymerase-associated subunit B 2 3 3 3 ---------|||---------------- 3 [U] COG5215 Karyopherin (importin) beta 2 3 3 3 ---------|||---------------- 3 [S] COG5216 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [DZ] COG5217 Microtubule-binding protein involved in cell cycle control 2 3 3 3 ---------|||---------------- 3 [BD] COG5218 Chromosome condensation complex Condensin, subunit G 2 3 3 3 ---------|||---------------- 3 [R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger 2 3 3 3 ---------|||---------------- 3 [DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3 2 3 3 3 ---------|||---------------- 3 [K] COG5221 Dopey and related predicted leucine zipper transcription factors 2 3 3 3 ---------|||---------------- 3 [R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger 2 3 3 3 ---------|||---------------- 3 [S] COG5223 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [K] COG5224 CCAAT-binding factor, subunit B 2 3 3 3 ---------|||---------------- 3 [J] COG5225 Uncharacterized protein involved in ribosome biogenesis 2 3 3 3 ---------|||---------------- 3 [A] COG5226 mRNA capping enzyme, guanylyltransferase (alpha) subunit 2 3 3 3 ---------|||---------------- 3 [O] COG5227 Ubiquitin-like protein (sentrin) 2 3 3 3 ---------|||---------------- 3 [A] COG5228 mRNA deadenylase subunit 2 3 3 3 ---------|||---------------- 3 [BD] COG5229 Chromosome condensation complex Condensin, subunit H 2 3 3 3 ---------|||---------------- 3 [S] COG5230 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [C] COG5231 Vacuolar H+-ATPase V1 sector, subunit H 2 3 3 3 ---------|||---------------- 3 [U] COG5232 Preprotein translocase subunit Sec62 2 3 3 3 ---------|||---------------- 3 [U] COG5233 Peripheral Golgi membrane protein 2 3 3 3 ---------|||---------------- 3 [OZ] COG5234 Beta-tubulin folding cofactor D 2 3 3 3 ---------|||---------------- 3 [L] COG5235 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit 2 3 3 3 ---------|||---------------- 3 [R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger 2 3 3 3 ---------|||---------------- 3 [S] COG5237 Predicted membrane protein 2 3 3 3 ---------|||---------------- 3 [TA] COG5238 Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport 2 3 3 3 ---------|||---------------- 7 [A] COG5239 mRNA deadenylase, exonuclease subunit and related nucleases 2 3 3 3 ---------|||---------------- 3 [U] COG5240 Vesicle coat complex COPI, gamma subunit 2 3 3 3 ---------|||---------------- 3 [L] COG5241 Nucleotide excision repair endonuclease NEF1, RAD10 subunit 2 3 3 3 ---------|||---------------- 3 [KL] COG5242 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4 2 3 3 3 ---------|||---------------- 3 [O] COG5243 HRD ubiquitin ligase complex, ER membrane component 2 3 3 3 ---------|||---------------- 3 [D] COG5244 Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B 2 3 3 3 ---------|||---------------- 3 [Z] COG5245 Dynein, heavy chain 2 3 3 3 ---------|||---------------- 3 [A] COG5246 Splicing factor 3a, subunit 2 2 3 3 3 ---------|||---------------- 3 [K] COG5247 Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) 2 3 3 3 ---------|||---------------- 3 [K] COG5248 Transcription initiation factor TFIID, subunit TAF13 2 3 3 3 ---------|||---------------- 3 [U] COG5249 Golgi protein involved in Golgi-to-ER retrieval 2 3 3 3 ---------|||---------------- 3 [K] COG5250 RNA polymerase II, fourth largest subunit 2 3 3 3 ---------|||---------------- 3 [K] COG5251 Transcription initiation factor TFIID, subunit TAF11 2 3 3 3 ---------|||---------------- 3 [R] COG5252 Uncharacterized conserved protein, contains CCCH-type Zn-finger protein 2 3 3 3 ---------|||---------------- 5 [T] COG5253 Phosphatidylinositol-4-phosphate 5-kinase 2 3 3 3 ---------|||---------------- 3 [S] COG5254 Predicted membrane protein 2 3 3 3 ---------|||---------------- 5 [BK] COG5259 RSC chromatin remodeling complex subunit RSC8 2 3 3 3 ---------|||---------------- 9 [L] COG5260 DNA polymerase sigma 2 3 3 3 ---------|||---------------- 4 [DT] COG5261 Protein involved in regulation of cellular morphogenesis/cytokinesis 2 3 3 3 ---------|||---------------- 7 [B] COG5262 Histone H2A 2 3 3 3 ---------|||---------------- 8 [O] COG5264 Vacuolar transporter chaperone 1 3 3 4 ------------------------||-| 4 [NU] COG5268 Type IV secretory pathway, TrbD component 2 3 3 3 ---------|||---------------- 3 [JO] COG5269 Ribosome-associated chaperone zuotin 2 3 3 3 ---------|||---------------- 3 [R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain 2 3 3 3 ---------|||---------------- 22 [O] COG5272 Ubiquitin 2 3 3 3 ---------|||---------------- 17 [R] COG5273 Uncharacterized protein containing DHHC-type Zn finger 2 3 3 3 ---------|||---------------- 12 [CI] COG5274 Cytochrome b involved in lipid metabolism 2 3 3 3 ---------|||---------------- 3 [R] COG5275 BRCT domain type II 3 3 3 3 --|----------|----------|--- 4 [S] COG5276 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 23 [Z] COG5277 Actin and related proteins 3 3 4 6 --|-------------|-----|----- 6 [S] COG5280 Phage-related minor tail protein 1 3 4 8 ------------------------||-| 33 [S] COG5281 Phage-related minor tail protein 2 3 5 7 ---------------------||-|--- 9 [S] COG5283 Phage-related tail protein 2 3 3 3 ---------|||---------------- 3 [K] COG5290 IkappaB kinase complex, IKAP component 2 3 3 3 ---------|||---------------- 3 [S] COG5291 Predicted membrane protein 3 3 3 3 --------------|-------|-|--- 3 [S] COG5293 Uncharacterized protein conserved in bacteria 2 3 3 3 ---------|||---------------- 3 [K] COG5296 Transcription factor involved in TATA site selection and in elongation by RNA polymerase II 2 3 3 4 --------------------|---||-- 4 [G] COG5297 Cellobiohydrolase A (1,4-beta-cellobiosidase A) 2 3 3 7 --------------------|---|--| 7 [R] COG5302 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid 2 3 3 3 ---------|||---------------- 4 [U] COG5308 Nuclear pore complex subunit 2 3 3 3 ---------||-------------|--- 6 [G] COG5309 Exo-beta-1,3-glucanase 1 3 3 4 ------------------------||-| 6 [U] COG5314 Conjugal transfer/entry exclusion protein 3 3 3 3 --|-------------|----------| 6 [S] COG5316 Uncharacterized conserved protein 2 3 3 3 ---------||------|---------- 3 [S] COG5324 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 6 [U] COG5325 t-SNARE complex subunit, syntaxin 2 3 3 3 ---------|||---------------- 11 [T] COG5329 Phosphoinositide polyphosphatase (Sac family) 2 3 3 3 ---------|||---------------- 9 [DKL] COG5333 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit 3 3 3 3 --|-----------------|-|----- 4 [M] COG5337 Spore coat assembly protein 2 3 5 11 ----------------|-------||-- 14 [S] COG5339 Uncharacterized protein conserved in bacteria 2 3 3 5 ---|-|--------------|------- 7 [K] COG5340 Predicted transcriptional regulator 3 3 4 4 -------------|---|----|----- 5 [S] COG5341 Uncharacterized protein conserved in bacteria 2 3 3 5 --------------|----------|-| 5 [S] COG5346 Predicted membrane protein 2 3 3 3 ---------|||---------------- 14 [U] COG5347 GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport 2 3 3 3 ---------|||---------------- 5 [R] COG5354 Uncharacterized protein, contains Trp-Asp (WD) repeat 3 3 4 4 --|-------------------|----| 4 [R] COG5362 Phage-related terminase 2 3 3 3 ---------|||---------------- 4 [R] COG5366 Protein involved in propagation of M2 dsRNA satellite of L-A virus 2 3 3 3 ---------|||---------------- 3 [S] COG5369 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 5 [GO] COG5371 Golgi nucleoside diphosphatase 1 3 4 6 ------------------------||-| 7 [S] COG5373 Predicted membrane protein 2 3 3 3 ---------|||---------------- 5 [S] COG5374 Uncharacterized conserved protein 2 3 3 3 -|---|--|------------------- 3 [R] COG5378 Predicted nucleotide-binding protein 2 3 3 9 --------------------|---|--| 11 [S] COG5383 Uncharacterized protein conserved in bacteria 2 3 3 3 ---------|||---------------- 3 [J] COG5384 U3 small nucleolar ribonucleoprotein component 2 3 4 6 ---------||----------------| 6 [O] COG5387 Chaperone required for the assembly of the mitochondrial F1-ATPase 2 3 3 3 ---------|||---------------- 13 [UR] COG5391 Phox homology (PX) domain protein 2 3 3 3 ---------|||---------------- 3 [KLB] COG5406 Nucleosome binding factor SPN, SPT16 subunit 2 3 3 3 ---------|||---------------- 3 [U] COG5407 Preprotein translocase subunit Sec63 2 3 3 3 ---------|||---------------- 8 [T] COG5408 SPX domain-containing protein 2 3 3 3 ---------|||---------------- 6 [T] COG5409 EXS domain-containing protein 2 3 3 4 ----------------------|-|--| 6 [S] COG5410 Uncharacterized protein conserved in bacteria 2 3 3 3 ---------|||---------------- 8 [T] COG5411 Phosphatidylinositol 5-phosphate phosphatase 2 3 3 4 --------------||--------|--- 4 [S] COG5413 Uncharacterized integral membrane protein 2 3 3 3 ---------|||---------------- 3 [K] COG5414 TATA-binding protein-associated factor 2 3 3 3 ---------|||---------------- 3 [R] COG5415 Predicted integral membrane metal-binding protein 3 3 4 10 --------------------|-|--|-- 10 [S] COG5416 Uncharacterized integral membrane protein 1 3 3 4 -||--|---------------------- 4 [S] COG5418 Predicted secreted protein 1 3 4 4 ------------------------||-| 7 [S] COG5419 Uncharacterized conserved protein 2 3 3 3 --|-|---------|------------- 24 [L] COG5421 Transposase 2 3 3 3 ---------|||---------------- 5 [T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases 1 3 3 4 --|--||--------------------- 6 [S] COG5423 Predicted metal-binding protein 1 3 3 3 --||--|--------------------- 4 [S] COG5427 Uncharacterized membrane protein 1 3 5 6 ------------------------||-| 19 [S] COG5430 Uncharacterized secreted protein 2 3 3 3 ---------|||---------------- 3 [T] COG5432 RING-finger-containing E3 ubiquitin ligase 2 3 4 4 |-----|-|------------------- 5 [S] COG5440 Uncharacterized conserved protein 1 3 4 10 ------------------------||-| 10 [S] COG5455 Predicted integral membrane protein 2 3 3 4 ---------||----------------| 4 [J] COG5459 Predicted rRNA methylase 2 3 4 4 ----------------------|-|--| 4 [S] COG5460 Uncharacterized conserved protein 2 3 3 4 --------------||-----------| 8 [S] COG5469 Predicted metal-binding protein 2 3 3 6 --|----------------------|-| 11 [S] COG5470 Uncharacterized conserved protein 1 3 3 3 ------------------------|||- 4 [S] COG5472 Predicted small integral membrane protein 2 3 3 3 --------------||--------|--- 3 [S] COG5474 Uncharacterized conserved protein 3 3 3 6 --|-------------|---|------- 15 [M] COG5479 Uncharacterized protein potentially involved in peptidoglycan biosynthesis 1 3 4 9 ------------------------||-| 10 [S] COG5487 Small integral membrane protein 2 3 4 4 --------|||----------------- 12 [N] COG5491 Conserved protein implicated in secretion 2 3 3 7 ---------------------||-|--- 38 [N] COG5492 Bacterial surface proteins containing Ig-like domains 3 3 3 5 -------------|------|----|-- 5 [S] COG5495 Uncharacterized conserved protein 3 3 3 5 ----------------|--|-------| 7 [S] COG5497 Predicted secreted protein 2 3 3 3 ---------||-----------|----- 5 [M] COG5498 Predicted glycosyl hydrolase 2 3 3 7 --------------|---------|--| 7 [K] COG5499 Predicted transcription regulator containing HTH domain 2 3 3 3 ------------|------------|-| 3 [S] COG5501 Predicted secreted protein 3 3 3 4 ------------|-|------------| 7 [S] COG5502 Uncharacterized conserved protein 3 3 3 4 -----|-----------|----|----- 4 [S] COG5505 Predicted integral membrane protein 1 3 5 6 ------------------------||-| 9 [S] COG5510 Predicted small secreted protein 3 3 3 3 --|------------------|--|--- 7 [S] COG5513 Predicted secreted protein 2 3 4 6 --------------------|---||-- 8 [Q] COG5517 Small subunit of phenylpropionate dioxygenase 2 3 3 4 ----------------------|-||-- 5 [R] COG5518 Bacteriophage capsid portal protein 3 3 4 7 --|-------------------|-|--- 12 [L] COG5519 Superfamily II helicase and inactivated derivatives 2 3 3 4 ---------------------||--|-- 4 [L] COG5527 Protein involved in initiation of plasmid replication 2 3 3 3 --|---------------------|--| 3 [R] COG5529 Pyocin large subunit 2 3 3 3 ---------|||---------------- 4 [O] COG5533 Ubiquitin C-terminal hydrolase 2 3 3 3 ----------------|--------|-| 4 [L] COG5534 Plasmid replication initiator protein 2 3 3 3 ---------|||---------------- 5 [L] COG5535 DNA repair protein RAD4 2 3 3 3 ---------|||---------------- 5 [O] COG5536 Protein prenyltransferase, alpha subunit 2 3 3 3 ---------|||---------------- 4 [D] COG5537 Cohesin 2 3 3 3 ---------|||---------------- 3 [U] COG5538 Preprotein translocase subunit Sec66 2 3 3 3 ---------|||---------------- 5 [O] COG5539 Predicted cysteine protease (OTU family) 2 3 3 3 ---------|||---------------- 4 [O] COG5540 RING-finger-containing ubiquitin ligase 2 3 3 3 ---------|||---------------- 3 [O] COG5541 Vesicle coat complex COPI, zeta subunit 2 3 3 3 ---------|||---------------- 3 [S] COG5543 Uncharacterized conserved protein 3 3 3 3 --------------|-------|-|--- 4 [R] COG5545 Predicted P-loop ATPase and inactivated derivatives 2 3 3 3 ---------||---|------------- 3 [S] COG5548 Small integral membrane protein 2 3 3 3 --------------|---------|--| 3 [R] COG5553 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily 2 3 3 6 ---|--|-----------------|--- 7 [C] COG5557 Polysulphide reductase 2 3 3 3 ----|-|-|------------------- 9 [L] COG5558 Transposase 2 3 3 3 -----||--------|------------ 4 [S] COG5559 Uncharacterized conserved small protein 2 3 3 3 ---------|||---------------- 4 [O] COG5560 Ubiquitin C-terminal hydrolase 1 3 3 3 -||---|--------------------- 4 [S] COG5561 Predicted metal-binding protein 3 3 4 9 --------------------|-|-|--- 11 [R] COG5562 Phage envelope protein 1 3 3 6 ------------------------||-| 7 [S] COG5569 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 6 [O] COG5574 RING-finger-containing E3 ubiquitin ligase 2 3 3 3 ---------|||---------------- 3 [L] COG5575 Origin recognition complex, subunit 2 2 3 3 3 ---------|||---------------- 14 [K] COG5576 Homeodomain-containing transcription factor 2 3 3 3 ---------|||---------------- 4 [O] COG5580 Activator of HSP90 ATPase 2 3 3 4 ---------------------||-|--- 5 [S] COG5583 Uncharacterized small protein 2 3 4 4 --|------------------||----- 14 [T] COG5585 NAD+--asparagine ADP-ribosyltransferase 2 3 4 5 ---------||----------------| 5 [S] COG5590 Uncharacterized conserved protein 1 3 3 3 ------------------------||-| 4 [S] COG5591 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis 2 3 3 3 ---------|||---------------- 8 [S] COG5594 Uncharacterized integral membrane protein 2 3 3 3 ---------|||---------------- 7 [O] COG5596 Mitochondrial import inner membrane translocase, subunit TIM22 2 3 3 3 ---------||----------------| 5 [M] COG5597 Alpha-N-acetylglucosamine transferase 2 3 3 3 ---------|||---------------- 6 [T] COG5599 Protein tyrosine phosphatase 2 3 3 3 ---------|||---------------- 5 [L] COG5600 Transcription-associated recombination protein 2 3 3 3 ---------|||---------------- 3 [K] COG5601 General negative regulator of transcription subunit 2 3 3 3 ---------|||---------------- 5 [B] COG5602 Histone deacetylase complex, SIN3 component 2 3 3 3 ---------|||---------------- 3 [N] COG5603 Subunit of TRAPP, an ER-Golgi tethering complex 2 3 3 3 ---------|||---------------- 4 [S] COG5604 Uncharacterized conserved protein 2 3 3 4 -----||-----------------|--- 6 [S] COG5608 Conserved secreted protein 3 3 3 4 ----|---|---------------|--- 4 [S] COG5615 Predicted integral membrane protein 2 3 3 3 -----|-|-------------|------ 7 [S] COG5617 Predicted integral membrane protein 2 3 3 3 ---------|||---------------- 3 [A] COG5623 Pre-mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1 2 3 3 3 ---------|||---------------- 3 [K] COG5624 Transcription initiation factor TFIID, subunit TAF12 (also component of histone acetyltransferase SAGA) 2 3 4 5 -----||-|------------------- 5 [K] COG5625 Predicted transcription regulator containing HTH domain 2 3 3 3 --------------||--------|--- 3 [S] COG5626 Uncharacterized conserved small protein 2 3 3 3 ---------|||---------------- 3 [L] COG5627 DNA repair protein MMS21 2 3 3 3 ---------|||---------------- 3 [S] COG5629 Predicted metal-binding protein 2 3 3 3 ---------||-------------|--- 3 [E] COG5630 Acetylglutamate synthase 3 3 3 3 --------------|-------|--|-- 3 [S] COG5634 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 3 [S] COG5636 Uncharacterized conserved protein, contains Zn-ribbon-like motif 2 3 3 3 --------------|||----------- 5 [S] COG5637 Predicted integral membrane protein 2 3 3 3 ---------|||---------------- 3 [S] COG5638 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 13 [K] COG5641 GATA Zn-finger-containing transcription factor 1 3 3 3 |-|----|-------------------- 7 [R] COG5643 Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E 2 3 3 3 ---------|||---------------- 3 [S] COG5644 Uncharacterized conserved protein 3 3 4 6 --------------------|-|----| 7 [S] COG5646 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 6 [O] COG5647 Cullin, a subunit of E3 ubiquitin ligase 2 3 3 3 ---------|||---------------- 10 [B] COG5648 Chromatin-associated proteins containing the HMG domain 2 3 3 7 ----|--|------------|------- 10 [S] COG5650 Predicted integral membrane protein 3 3 3 6 -----------------|--|-----|- 145 [N] COG5651 PPE-repeat proteins 2 3 3 5 --------------------|---|--| 9 [S] COG5654 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 4 [O] COG5656 Importin, protein involved in nuclear import 2 3 3 3 ---------|||---------------- 7 [D] COG5657 CAS/CSE protein involved in chromosome segregation 2 3 3 3 ---------------|---------|-| 18 [L] COG5659 FOG: Transposase 3 3 3 6 -------------------||-|----- 6 [S] COG5660 Predicted integral membrane protein 2 3 3 4 ---------------------||----| 4 [S] COG5663 Uncharacterized conserved protein 2 3 3 3 ---------|||---------------- 4 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit 2 3 3 4 ----|-|-|------------------- 4 [S] COG5666 Uncharacterized conserved protein