y a o g aaaaaaaaaaaaaaaaaaaaaaaaaaaa 10 16 23 39 --|------||-|||||--||||-|||| 41 [E] COG0014 Gamma-glutamyl phosphate reductase 10 16 21 35 ---||---||||--|||-|-|-||||-| 56 [C] COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit 9 16 24 48 --|------||-||||-|--|||||||| 53 [C] COG0055 F0F1-type ATP synthase, beta subunit 9 16 24 48 --|------||-||||-|--|||||||| 53 [C] COG0056 F0F1-type ATP synthase, alpha subunit 11 16 21 35 -||--|--||--|-|||||-|||-|--| 43 [G] COG0058 Glucan phosphorylase 10 16 23 42 ---------||-|||||||-|||-|||| 42 [H] COG0117 Pyrimidine deaminase 8 16 16 20 |||-|||||||||-||---|-------| 25 [I] COG0170 Dolichol kinase 9 16 22 45 ---------||-|||||--||||||||| 71 [G] COG0191 Fructose/tagatose bisphosphate aldolase 9 16 24 48 --|------||-||||-|--|||||||| 50 [C] COG0224 F0F1-type ATP synthase, gamma subunit 10 16 24 50 ------------|||||||||||||||| 65 [J] COG0242 N-formylmethionyl-tRNA deformylase 10 16 22 41 ------------|||||||||||||||| 41 [I] COG0245 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 11 16 23 38 --|-----||--||||||--|||-|||| 54 [FP] COG0248 Exopolyphosphatase 10 16 24 50 ------------|||||||||||||||| 64 [J] COG0254 Ribosomal protein L31 11 16 23 44 --------|-|||-|||||-|-|||||| 61 [E] COG0260 Leucyl aminopeptidase 10 16 24 50 ------------|||||||||||||||| 50 [J] COG0261 Ribosomal protein L21 10 16 23 39 --|------||-|||||--||||-|||| 43 [E] COG0263 Glutamate 5-kinase 10 16 24 50 ------------|||||||||||||||| 50 [J] COG0268 Ribosomal protein S20 7 16 24 34 ||---|-||-|---||----|||||||| 63 [L] COG0270 Site-specific DNA methylase 10 16 24 50 ------------|||||||||||||||| 57 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) 10 16 20 39 |--||---|---|||||--||||||--| 44 [F] COG0274 Deoxyribose-phosphate aldolase 10 16 24 50 ------------|||||||||||||||| 50 [M] COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis 11 16 24 47 -----------|||||||||||||||-| 48 [F] COG0283 Cytidylate kinase 10 16 24 50 ------------|||||||||||||||| 51 [J] COG0290 Translation initiation factor 3 (IF-3) 10 16 24 50 ------------|||||||||||||||| 50 [J] COG0292 Ribosomal protein L20 11 16 21 32 -|---|--|-|-|||||||--||-||-| 38 [G] COG0297 Glycogen synthase 10 16 24 46 ---------||-|||||||-|||-|||| 105 [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase 10 16 24 50 ------------|||||||||||||||| 63 [L] COG0305 Replicative DNA helicase 10 16 24 50 ------------|||||||||||||||| 53 [R] COG0313 Predicted methyltransferases 10 16 24 50 ------------|||||||||||||||| 50 [R] COG0319 Predicted metal-dependent hydrolase 10 16 23 43 --|------||-||||||--|||-|||| 44 [R] COG0325 Predicted enzyme with a TIM-barrel fold 10 16 24 45 ---------||-|||||||-|||-|||| 65 [I] COG0331 (acyl-carrier-protein) S-malonyltransferase 10 16 24 50 ------------|||||||||||||||| 50 [J] COG0336 tRNA-(guanine-N1)-methyltransferase 8 16 23 35 |||---||----|||||---|||-||-| 67 [E] COG0347 Nitrogen regulatory protein PII 9 16 24 48 --|------||-||||-|--|||||||| 50 [C] COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) 11 16 23 41 ---------||||||||-|||-|-|||| 48 [G] COG0364 Glucose-6-phosphate 1-dehydrogenase 9 16 20 34 --|-|---|||--||||---||||||-| 137 [G] COG0366 Glycosidases 8 16 23 38 --|||||-|---|||||---|---|||| 39 [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases 9 16 19 31 ||||--||-|--|||||---|||-|--- 34 [S] COG0391 Uncharacterized conserved protein 9 16 23 41 ---|||--|----||||--|||||||-| 207 [G] COG0395 ABC-type sugar transport system, permease component 10 16 21 35 ---|||--|||-|||||---|-|-||-| 36 [E] COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain 10 16 21 36 ---|||--|||-|||||---|-|-||-| 79 [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase) 8 16 17 24 ||-|-|||----|||----||||-|||- 46 [D] COG0455 ATPases involved in chromosome partitioning 10 16 23 42 --|------||-||--||||-||||||| 46 [O] COG0466 ATP-dependent Lon protease, bacterial type 11 16 23 34 --|-----||||--||||-||||-||-| 46 [L] COG0514 Superfamily II DNA helicase 10 16 24 50 ------------|||||||||||||||| 51 [O] COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) 10 16 24 50 ------------|||||||||||||||| 103 [K] COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) 8 16 21 35 ----|||-|----|||-|--|||||||| 44 [R] COG0579 Predicted dehydrogenase 8 16 23 40 ||----||----|-||||--|||-|||| 904 [K] COG0583 Transcriptional regulator 7 16 21 30 |||||||||||||---|-------|-|- 31 [S] COG0585 Uncharacterized conserved protein 10 16 24 50 ------------|||||||||||||||| 67 [L] COG0587 DNA polymerase III, alpha subunit 10 16 24 50 ------------|||||||||||||||| 50 [MU] COG0597 Lipoprotein signal peptidase 9 16 20 30 -||---||-----||||||-|||-||-| 92 [P] COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component 9 16 18 31 ----|----||-|-|||-|-|||||||| 55 [T] COG0631 Serine/threonine protein phosphatase 10 16 24 46 ------------|||||||||||||||| 85 [H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases 8 16 23 38 --|||||-|---|||||---|---|||| 41 [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 8 16 21 33 |||||||-|----||||---|-|-|--| 69 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit 10 16 24 50 ------------|||||||||||||||| 61 [U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase) 10 16 24 47 ------------|||||||||||||||| 47 [R] COG0658 Predicted membrane metal-binding protein 11 16 23 32 ----|---||||--||||-|||--|||| 96 [R] COG0666 FOG: Ankyrin repeat 9 16 18 25 -|||||-||---|||||--||---|-|- 189 [L] COG0675 Transposase and inactivated derivatives 10 16 24 50 ------------|||||||||||||||| 50 [M] COG0682 Prolipoprotein diacylglyceryltransferase 10 16 24 50 ------------|||||||||||||||| 50 [U] COG0690 Preprotein translocase subunit SecE 10 16 24 50 ------------|||||||||||||||| 50 [O] COG0691 tmRNA-binding protein 7 16 18 28 |||||||||||-|-----|---|-||-- 28 [E] COG0710 3-dehydroquinate dehydratase 7 16 21 32 |||---||-||---||-|-|-||-|||- 71 [C] COG0716 Flavodoxins 10 16 21 46 ---------||-||--|||||||||||| 49 [I] COG0736 Phosphopantetheinyl transferase (holo-ACP synthase) 11 16 24 46 ---------|--|||||||||||-|||| 46 [L] COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains 10 16 24 43 ---------|||||||||-|-||-|||| 109 [O] COG0760 Parvulin-like peptidyl-prolyl isomerase 10 16 24 41 --|---|-|----||||||-|||-|||| 191 [E] COG0765 ABC-type amino acid transport system, permease component 10 16 24 50 ------------|||||||||||||||| 50 [K] COG0781 Transcription termination factor 11 16 24 42 ----|---|---||||||||-||-|||| 56 [M] COG0793 Periplasmic protease 7 16 25 41 |||--||||---|----||--||-|||| 51 [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation 10 16 24 44 ---------||-|||||||-|||-|||| 48 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase 10 16 24 46 ------------|||||||||||||||| 46 [R] COG0802 Predicted ATPase or kinase 8 16 23 38 --|||||-|---|||||---|---|||| 40 [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit 10 16 24 50 ------------|||||||||||||||| 50 [J] COG0858 Ribosome-binding factor A 10 16 21 35 ---|||--|||-|||||---|-|-||-| 36 [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain 8 16 24 42 --|||||-|---|-|||---|-|-|||| 65 [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit 10 16 24 39 ---||-|-|||-|-|-||--|||-||-| 245 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase 9 16 24 40 ----||--|||-|-||-|-|-||-|||| 92 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases 9 16 22 45 ---------||-||||-|-||||||||| 50 [H] COG1057 Nicotinic acid mononucleotide adenylyltransferase 10 16 21 35 ---||---||||--|||-|-|-||||-| 58 [C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit 9 16 21 34 |---|-||----|||--|||-||-|||| 43 [D] COG1077 Actin-like ATPase involved in cell morphogenesis 7 16 19 33 |||--||||----|||----|||-||-| 115 [G] COG1082 Sugar phosphate isomerases/epimerases 9 16 22 37 |--------||-|-||||--|||||||| 54 [M] COG1087 UDP-glucose 4-epimerase 10 16 24 41 --|---|-|----||||||-|||-|||| 130 [E] COG1126 ABC-type polar amino acid transport system, ATPase component 10 16 24 50 ------------|||||||||||||||| 52 [R] COG1160 Predicted GTPases 10 16 26 44 ---||---|||--|||||--|-|-|||| 75 [E] COG1171 Threonine dehydratase 9 16 23 42 ---|||--|----||||--|||||||-| 219 [G] COG1175 ABC-type sugar transport systems, permease components 8 16 22 33 |||-|||||---||---|--|||-||-- 70 [O] COG1180 Pyruvate-formate lyase-activating enzyme 11 16 24 46 --|---------|||||||||||-|||| 65 [M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes 10 16 24 47 ------------|||||||||||||||| 99 [J] COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases 10 16 24 50 ------------|||||||||||||||| 50 [O] COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone 11 16 24 47 ---------|--|||||||||||-|||| 47 [O] COG1219 ATP-dependent protease Clp, ATPase subunit 9 16 20 28 |--||||-||---|--||--|||-||-| 45 [Q] COG1228 Imidazolonepropionase and related amidohydrolases 7 16 20 23 -||||||-||||--|||-------||-| 37 [J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing 9 16 22 34 -||-|||-|----||-|--||||-||-| 42 [C] COG1254 Acylphosphatases 10 16 18 28 |-||-||------||||||||||----| 34 [R] COG1268 Uncharacterized conserved protein 9 16 18 25 |-|-|||||--||||-|-|-----||-| 25 [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations 7 16 19 26 ||||||||||||-|---|---||----- 41 [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a) 8 16 17 21 ||||||||||||----||||-------- 21 [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E 8 16 18 20 ||||||||||||----||-|--|----- 20 [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F 7 16 22 34 ||||-||-----|---||--||-||||| 43 [R] COG1451 Predicted metal-dependent hydrolase 6 16 23 37 |||||||||-------|---|||-||-| 250 [K] COG1522 Transcriptional regulators 7 16 17 26 ||-|-|-|-||-|-|-----|-|||||| 50 [L] COG1525 Micrococcal nuclease (thermonuclease) homologs 10 16 25 42 ---|-|-||---||||-||-|||-||-| 56 [J] COG1530 Ribonucleases G and E 8 16 20 26 -||-|||||----|-|-|--|||-||-| 36 [L] COG1533 DNA repair photolyase 9 16 21 36 --||-----||--|--||-||||||||| 38 [S] COG1739 Uncharacterized conserved protein 8 16 21 34 -||-||-||---||--|---||||||-| 44 [O] COG1765 Predicted redox protein, regulator of disulfide bond formation 9 16 19 21 ||--|||||||--|--|-|-|-|-|--| 30 [S] COG1814 Uncharacterized membrane protein 8 16 25 44 --|||-|||---|-|||---|-|-|||| 86 [U] COG1826 Sec-independent protein secretion pathway components 7 16 18 25 |||||||-|----|||----|-|-||-| 30 [R] COG1878 Predicted metal-dependent hydrolase 10 16 22 40 ------------|||||||||||||||| 40 [I] COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase 8 16 21 36 --|||||-|---|-|||---|-|-|||| 56 [H] COG1977 Molybdopterin converting factor, small subunit 10 16 20 27 --|-||||||--||--||--|-|-||-| 33 [R] COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 9 16 19 28 |-||--|---|-|||||---|||-||-| 172 [T] COG2203 FOG: GAF domain 7 16 18 24 |||||-|||-----||-|--|||-|--| 26 [H] COG2242 Precorrin-6B methylase 2 10 16 24 50 ------------|||||||||||||||| 55 [L] COG2812 DNA polymerase III, gamma/tau subunits 7 16 19 25 ||||||||||||-------|--|-|--| 27 [I] COG3425 3-hydroxy-3-methylglutaryl CoA synthase 9 16 20 34 ---||-|||----|||||--|||-||-| 116 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily