y a o g aaaaaaaaaaaaaaaaaaaaaaaaaaaa 5 12 12 18 |||--|||----|-||-----|--|-|- 20 [O] COG0068 Hydrogenase maturation factor 7 12 19 32 -|---||||------|||---||-||-- 32 [L] COG0116 Predicted N6-adenine-specific DNA methylase 6 12 17 28 ||--||--||----||----|---||-| 37 [R] COG0121 Predicted glutamine amidotransferase 4 12 13 13 ||||--||------||-----||-|--| 24 [P] COG0310 ABC-type Co2+ transport system, permease component 8 12 19 35 --|------||-|-|||---|-|-||-| 80 [S] COG0316 Uncharacterized conserved protein 5 12 12 18 |||--|||----|-|||-------|-|- 24 [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) 7 12 16 26 ---------|||---|-|--||||||-| 36 [O] COG0386 Glutathione peroxidase 5 12 12 18 |||--|||----|-||-----|--|-|- 19 [O] COG0409 Hydrogenase maturation factor 7 12 16 23 |-||----||----||----|-|-||-| 28 [L] COG0415 Deoxyribodipyrimidine photolyase 7 12 18 33 ---|-----||---|||---|-||||-| 59 [R] COG0431 Predicted flavoprotein 7 12 16 30 ---|-----||---|||---|-|-|||| 32 [E] COG0506 Proline dehydrogenase 8 12 17 34 --|------||------||||||-||-| 37 [G] COG0588 Phosphoglycerate mutase 1 6 12 15 25 |||---||-|------|---|-|-||-| 34 [H] COG0684 Demethylmenaquinone methyltransferase 8 12 18 28 ---|-----||-|-|||---|-|-||-| 102 [MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases 7 12 19 39 -------------|||||--|||-|||| 91 [M] COG0744 Membrane carboxypeptidase (penicillin-binding protein) 7 12 17 28 -------------|||||--|||-|||| 31 [E] COG0757 3-dehydroquinate dehydratase II 7 12 20 46 -------------|--|-|||||||||| 83 [K] COG0782 Transcription elongation factor 8 12 18 35 ------------|||||-|||---|||| 39 [M] COG0815 Apolipoprotein N-acyltransferase 8 12 19 35 -------------||||||||---|||| 35 [L] COG0817 Holliday junction resolvasome, endonuclease subunit 6 12 20 42 ------------|-||--||-||||||| 46 [J] COG0828 Ribosomal protein S21 9 12 18 33 ---|----||--|-|||---|-|-||-| 60 [C] COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 8 12 20 39 -------|----||--||-|-||-|||| 42 [D] COG0849 Actin-like ATPase involved in cell division 7 12 17 29 ------------||||||---||-|||| 29 [D] COG0850 Septum formation inhibitor 7 12 16 30 ------------|||||---|||-|||| 31 [H] COG0853 Aspartate 1-decarboxylase 6 12 17 31 --|||-------|-|||---|---|||| 40 [C] COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M) 4 12 15 23 -||||||||-----|---------||-| 47 [C] COG1042 Acyl-CoA synthetase (NDP forming) 7 12 14 16 ------|--||---|||---||||||-- 24 [R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold 4 12 14 16 ||||||||||||---------------- 16 [R] COG1084 Predicted GTPase 4 12 14 16 ||||||||||||---------------- 16 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha) 4 12 14 16 ||||||||||||---------------- 19 [R] COG1094 Predicted RNA-binding protein (contains KH domains) 4 12 14 16 ||||||||||||---------------- 19 [K] COG1095 DNA-directed RNA polymerase, subunit E' 8 12 16 29 --|--|----------|||||-|-|||| 57 [E] COG1115 Na+/alanine symporter 6 12 19 30 --|---|-----|-||----|||-|||| 38 [GM] COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component 8 12 19 33 ------------||||||||----|||| 33 [R] COG1137 ABC-type (unclassified) transport system, ATPase component 4 12 14 16 ||||||||||||---------------- 19 [R] COG1163 Predicted GTPase 8 12 14 29 --||---------|--||||--|||-|| 41 [E] COG1164 Oligoendopeptidase F 8 12 14 25 ------------||||--|||||-|||- 45 [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit 9 12 19 36 --------|-----|||||||||-|--| 36 [L] COG1195 Recombinational DNA repair ATPase (RecF pathway) 7 12 14 18 ||||----|-----|||---|-|--|-| 53 [Q] COG1233 Phytoene dehydrogenase and related proteins 4 12 14 16 ||||||||||||---------------- 45 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family 4 12 14 16 ||||||||||||---------------- 16 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog 7 12 18 31 ---||-|-|-------||--|||-||-| 93 [I] COG1250 3-hydroxyacyl-CoA dehydrogenase 8 12 16 29 ---|----|||---|||---|-|-||-| 55 [C] COG1252 NADH dehydrogenase, FAD-containing subunit 8 12 17 33 ---------|||----||-||||-||-| 38 [R] COG1272 Predicted membrane protein, hemolysin III homolog 7 12 19 33 ------------||||||---|||||-| 34 [O] COG1281 Disulfide bond chaperones of the HSP33 family 8 12 15 26 ------------|-||||-||||-||-| 33 [S] COG1285 Uncharacterized membrane protein 7 12 18 33 --||--------|-||--|-|-|-|||| 46 [C] COG1294 Cytochrome bd-type quinol oxidase, subunit 2 4 12 13 15 ||||||||||||---------------- 15 [K] COG1308 Transcription factor homologous to NACalpha-BTF3 7 12 14 15 |||-|-|||----||--|--|-|----- 18 [L] COG1343 Uncharacterized protein predicted to be involved in DNA repair 6 12 13 14 |||-|||||---||------|-|----- 18 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs) 9 12 14 20 -------------||||||||||-|--| 69 [T] COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) 5 12 14 17 |||||||||---||------|------- 17 [S] COG1371 Uncharacterized conserved protein 8 12 12 16 -|--||-|||--|-|||---|-|----- 77 [L] COG1372 Intein/homing endonuclease 7 12 15 19 -||-||--|----|---|--|-|-|-|| 53 [R] COG1373 Predicted ATPase (AAA+ superfamily) 4 12 14 16 ||||||||||||---------------- 18 [J] COG1383 Ribosomal protein S17E 4 12 14 16 ||||||||||||---------------- 16 [U] COG1400 Signal recognition particle 19 kDa protein 4 12 14 16 ||||||||||||---------------- 39 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB 4 12 14 16 ||||||||||||---------------- 19 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily 8 12 15 30 ---||---|--|-|--|--|-||||--| 30 [F] COG1435 Thymidine kinase 5 12 14 15 ||||-||||----------|-|--||-- 17 [F] COG1437 Adenylate cyclase, class 2 (thermophilic) 4 12 14 16 ||||||||||||---------------- 16 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module 8 12 19 31 ------------|||||||--||-||-| 45 [NU] COG1459 Type II secretory pathway, component PulF 4 12 14 16 ||||||||||||---------------- 17 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit 4 12 14 16 ||||||||||||---------------- 19 [J] COG1471 Ribosomal protein S4E 5 12 13 18 ||||-||-------|-|----||-|--| 34 [K] COG1476 Predicted transcriptional regulators 9 12 19 30 --|---------||--||||-||-||-| 35 [H] COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis 6 12 17 21 -||--||-|-----|||---|---||-| 84 [R] COG1487 Predicted nucleic acid-binding protein, contains PIN domain 7 12 18 26 |---|-|-|---||||-----||-|--| 26 [R] COG1489 DNA-binding protein, stimulates sugar fermentation 4 12 14 16 ||||||||||||---------------- 21 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog 4 12 14 16 ||||||||||||---------------- 17 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay 4 12 14 16 ||||||||||||---------------- 16 [J] COG1500 Predicted exosome subunit 8 12 17 21 ---|||--|||----|||----|-|--| 48 [E] COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases 5 12 17 31 |||-|-|-|-----------|-|-|||| 32 [C] COG1526 Uncharacterized protein required for formate dehydrogenase activity 4 12 14 16 ||||||||||||---------------- 18 [R] COG1537 Predicted RNA-binding proteins 4 12 14 16 ||||||||||||---------------- 18 [J] COG1552 Ribosomal protein L40E 8 12 18 31 --|----------|||||--|||-|||- 40 [L] COG1555 DNA uptake protein and related DNA-binding proteins 8 12 20 41 -------------||-|||-|||-|||| 42 [L] COG1570 Exonuclease VII, large subunit 8 12 19 34 -------------|||||-||||-||-| 172 [K] COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog 8 12 15 28 ----|----||--||||---|||-|--| 46 [IR] COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase 4 12 13 15 ||||||||||||---------------- 26 [L] COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins 4 12 14 16 ||||||||||||---------------- 19 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain 7 12 16 25 ----|---------||||-|-|||||-| 31 [V] COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF 4 12 14 16 ||||||||||||---------------- 17 [J] COG1631 Ribosomal protein L44E 4 12 14 16 ||||||||||||---------------- 19 [J] COG1632 Ribosomal protein L15E 10 12 15 25 --------|---|-|||||||-|-||-- 26 [G] COG1640 4-alpha-glucanotransferase 4 12 14 16 ||||||||||||---------------- 16 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10) 5 12 13 22 |||-|||-----|----|-|-|||---- 24 [L] COG1658 Small primase-like proteins (Toprim domain) 7 12 20 42 --------------|-|-|||||||||| 84 [D] COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins 4 12 14 16 ||||||||||||---------------- 21 [J] COG1676 tRNA splicing endonuclease 7 12 18 35 --|--|--|-----|||---|||-||-| 111 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins 6 12 19 30 --|---|-----|-||----|||-|||| 37 [GM] COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component 9 12 20 36 -------||---|||||---|-|-||-| 42 [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase 4 12 14 16 ||||||||||||---------------- 17 [J] COG1717 Ribosomal protein L32E 4 12 18 25 ||||-||||----|----------||-| 28 [S] COG1720 Uncharacterized conserved protein 4 12 14 16 ||||||||||||---------------- 17 [J] COG1727 Ribosomal protein L18E 4 12 14 16 |||||||||||-|--------------- 17 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding 7 12 14 26 ---|--|-------|-||--|||-|||| 32 [M] COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) 4 12 14 16 ||||||||||||---------------- 19 [J] COG1736 Diphthamide synthase subunit DPH2 4 12 14 16 ||||||||||||---------------- 20 [K] COG1761 DNA-directed RNA polymerase, subunit L 4 12 14 16 ||||||||||||---------------- 16 [J] COG1798 Diphthamide biosynthesis methyltransferase 4 12 14 16 ||||||||||||---------------- 17 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1 7 12 14 19 |||----|-|-----||---|||-|--| 38 [GC] COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase 9 12 18 33 --------|----||-||-||||||--| 41 [G] COG1820 N-acetylglucosamine-6-phosphate deacetylase 7 12 15 27 ---|||--|---||--|-----|-|||| 27 [R] COG1832 Predicted CoA-binding protein 10 12 13 23 ------------|||||||||||---|- 25 [R] COG1837 Predicted RNA-binding protein (contains KH domain) 7 12 19 29 --||----|-----||-|--|-|-|||| 74 [P] COG1840 ABC-type Fe3+ transport system, periplasmic component 9 12 18 33 ---|----||--|-|||---|-|-||-| 56 [C] COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 6 12 14 18 --|-|||||||-----||------|--| 19 [J] COG1859 RNA:NAD 2'-phosphotransferase 8 12 20 42 ------------||---||||||-|||| 43 [U] COG1862 Preprotein translocase subunit YajC 6 12 16 23 |||--||||-----|---|-|---|--| 23 [S] COG1872 Uncharacterized conserved protein 4 12 14 16 ||||||||||||---------------- 16 [J] COG1889 Fibrillarin-like rRNA methylase 4 12 14 16 ||||||||||||---------------- 18 [J] COG1890 Ribosomal protein S3AE 6 12 18 29 ---|-||||||-----|-----|-|-|| 31 [R] COG1896 Predicted hydrolases of HD superfamily 4 12 14 16 ||||||||||||---------------- 16 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases) 7 12 17 30 ----||--|-----|||---|||-||-| 84 [L] COG1961 Site-specific recombinases, DNA invertase Pin homologs 4 12 14 16 ||||||||||||---------------- 16 [J] COG1976 Translation initiation factor 6 (eIF-6) 4 12 14 16 |||||||||||----------|------ 16 [K] COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) 4 12 14 16 ||||||||||||---------------- 19 [J] COG1997 Ribosomal protein L37AE/L43A 4 12 14 16 ||||||||||||---------------- 18 [J] COG2004 Ribosomal protein S24E 4 12 14 16 ||||||||||||---------------- 21 [J] COG2007 Ribosomal protein S8E 8 12 15 24 ---|-----||--||-||---||-||-| 27 [E] COG2008 Threonine aldolase 4 12 14 16 ||||||||||||---------------- 16 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5 4 12 14 16 ||||||||||||---------------- 16 [J] COG2016 Predicted RNA-binding protein (contains PUA domain) 7 12 17 29 ------------|-||||--|||-|||| 29 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis 4 12 13 15 ||||||||||||---------------- 15 [J] COG2023 RNase P subunit RPR2 8 12 15 24 ---|--|-|||-----||--|-|-||-| 79 [I] COG2030 Acyl dehydratase 4 12 14 16 ||||||||||||---------------- 17 [J] COG2051 Ribosomal protein S27E 4 12 14 16 ||||||||||||---------------- 18 [J] COG2053 Ribosomal protein S28E/S33 4 12 14 16 ||||||||||||---------------- 24 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2 4 12 14 16 ||||||||||||---------------- 21 [J] COG2075 Ribosomal protein L24E 5 12 12 14 ||||--||------|-----|-|-||-| 18 [R] COG2085 Predicted dinucleotide-binding enzymes 7 12 16 26 ---||||-|-------||--|-|-||-| 29 [S] COG2096 Uncharacterized conserved protein 4 12 14 16 ||||||||||||---------------- 17 [J] COG2097 Ribosomal protein L31E 4 12 14 16 ||||||||||||---------------- 28 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB 4 12 14 16 ||||||||||||---------------- 21 [R] COG2102 Predicted ATPases of PP-loop superfamily 8 12 12 22 --|--|-|||||----|---|-|-|--| 39 [S] COG2120 Uncharacterized proteins, LmbE homologs 4 12 14 16 ||||||||||||---------------- 18 [J] COG2125 Ribosomal protein S6E (S10) 4 12 13 15 ||||||||||||---------------- 16 [J] COG2126 Ribosomal protein L37E 8 12 17 29 ---|----|||-|-|-----|-|-|||| 54 [Q] COG2132 Putative multicopper oxidases 4 12 14 16 ||||||||||||---------------- 18 [J] COG2139 Ribosomal protein L21E 4 12 14 16 ||||||||||||---------------- 18 [J] COG2147 Ribosomal protein L19E 4 12 13 15 ||||||||||||---------------- 15 [J] COG2167 Ribosomal protein L39E 7 12 14 24 ---||||-|-------||--|-|-||-| 36 [I] COG2185 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) 8 12 16 29 ------------|||||--||||-||-| 359 [T] COG2199 FOG: GGDEF domain 6 12 14 23 ---||---------|||---|||-|||| 26 [P] COG2216 High-affinity K+ transport system, ATPase chain B 4 12 14 16 ||||||||||||---------------- 16 [L] COG2219 Eukaryotic-type DNA primase, large subunit 4 12 14 16 ||||||||||||---------------- 18 [J] COG2238 Ribosomal protein S19E (S16A) 7 12 19 35 ------------||||||---||-|||| 37 [J] COG2264 Ribosomal protein L11 methylase 6 12 14 22 ||-|---|------|-|---|-|-|||| 74 [E] COG2303 Choline dehydrogenase and related flavoproteins 9 12 15 21 --|---|-|-----||||-||-|-|--| 35 [R] COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain 10 12 13 19 ------|--|-|--|-||-||||-|--| 34 [S] COG2340 Uncharacterized protein with SCP/PR1 domains 4 12 12 14 ||||||||||||---------------- 14 [U] COG2443 Preprotein translocase subunit Sss1 7 12 14 15 --|--||||----|-|-|---||-|--| 16 [R] COG2509 Uncharacterized FAD-dependent dehydrogenases 4 12 14 16 ||||||||||||---------------- 32 [R] COG2520 Predicted methyltransferase 6 12 18 32 --------|||---||----|||-|||| 63 [E] COG2755 Lysophospholipase L1 and related esterases 9 12 15 20 ----||--|----||||||--||--|-- 22 [E] COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase 7 12 16 28 ------------||||||---||-|||| 28 [D] COG2894 Septum formation inhibitor-activating ATPase 4 12 13 15 ||||||||||||---------------- 15 [J] COG3277 RNA-binding protein involved in rRNA processing 7 12 14 17 --|-|-|-|-----|||---|-|-||-| 155 [L] COG3335 Transposase and inactivated derivatives 8 12 13 20 --|-|---|-----|-|--||||-||-| 48 [S] COG3391 Uncharacterized conserved protein 6 12 14 17 |-|||---------|-||---||-||-| 27 [R] COG3467 Predicted flavin-nucleotide-binding protein 5 12 16 24 -||||||-|-----|-----|---||-| 43 [K] COG3609 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain 4 12 14 16 ||||||||||||---------------- 16 [T] COG3642 Mn2+-dependent serine/threonine protein kinase 7 12 16 33 -------------|---||||||||||| 88 [E] COG4166 ABC-type oligopeptide transport system, periplasmic component 7 12 15 15 |||--||-----||---|-|--|-|-|- 19 [C] COG5016 Pyruvate/oxaloacetate carboxyltransferase 4 12 14 16 ||||||||||||---------------- 26 [J] COG5256 Translation elongation factor EF-1alpha (GTPase) 4 12 14 16 ||||||||||||---------------- 16 [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)