y a o g gggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggg 5 8 8 9 -------------|||--||----|-----------------------|-------||-------- 121 [R] COG0724 RNA-binding proteins (RRM domain) 1 3 3 9 ------------------------------------------|||-|-----------|||||--- 9 [I] COG1133 ABC-type long-chain fatty acid transport system, fused permease and ATPase components 4 5 5 9 --------|------------------||-------||-----------|---------||-|--- 18 [S] COG1273 Uncharacterized conserved protein 4 7 8 9 -|----|||||-|---||------------------------------------------------ 10 [K] COG1318 Predicted transcriptional regulators 2 3 6 9 ----------------------||---------------------|--||||-||----------- 9 [C] COG1347 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD 4 8 8 9 -|----||||--||||-------------------------------------------------- 9 [J] COG1374 Protein involved in ribosomal biogenesis, contains PUA domain 4 8 8 9 |--|||--|-------|----|---------------------------------|------|--- 10 [S] COG1416 Uncharacterized conserved protein 3 8 8 9 |||---||||--|---|------------------------------------------------- 9 [L] COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III 3 8 8 9 |||---||||--|---|------------------------------------------------- 9 [R] COG1458 Predicted DNA-binding protein containing PIN domain 3 4 6 9 -----------------|------------------|-----|||-|-||-----------|---- 10 [Q] COG1535 Isochorismate hydrolase 4 5 5 9 -----------------|---|-----||||----|||---------------------------- 9 [S] COG1550 Uncharacterized protein conserved in bacteria 3 8 8 9 |||--||||-------||------------------------------------------------ 14 [L] COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 4 9 9 9 |||-----||-------|||----------|----------------------------------- 11 [R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily 2 6 7 9 ||--|||||--||----------------------------------------------------- 10 [S] COG1630 Uncharacterized protein conserved in archaea 5 5 6 9 --|--------|----|-|-----------------------||||-----|-------------- 46 [L] COG1662 Transposase and inactivated derivatives, IS1 family 5 8 9 9 -||-----|--------||--|-------------------------------|-----|---|-- 24 [R] COG1669 Predicted nucleotidyltransferases 4 5 5 9 -----------------|------||----|-----||------------------|||------- 11 [S] COG1699 Uncharacterized protein conserved in bacteria 4 9 9 9 |||-----|||------|-------------------------------|-----|---------- 9 [R] COG1712 Predicted dinucleotide-utilizing enzyme 5 7 7 9 |-||---------------|-|-----||-------------|---|------------------- 11 [V] COG1715 Restriction endonuclease 4 7 8 9 --|--------------|||-------------------------|-----------|--|-||-- 13 [N] COG1724 Predicted periplasmic or secreted lipoprotein 2 3 6 9 ----------------------||---------------------|--||||-||----------- 9 [C] COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA 2 7 8 9 |||---||||||------------------------------------------------------ 15 [R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) 2 8 8 9 |||||||-|-|------------------------------------------------------- 9 [S] COG1860 Uncharacterized protein conserved in archaea 2 7 8 9 |-||--||||||------------------------------------------------------ 9 [S] COG1892 Uncharacterized protein conserved in archaea 2 7 8 9 |||---||||-||----------------------------------------------------- 13 [R] COG1907 Predicted archaeal sugar kinases 2 7 7 9 ||||----||-----------------|||------------------------------------ 9 [S] COG1920 Uncharacterized conserved protein 4 6 6 9 -------------|||--||------||||------------------------------------ 17 [O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase 2 8 8 9 |||---||||--------||---------------------------------------------- 16 [C] COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit 3 4 6 9 -------------|-------------||-------------|||---||-------------|-- 9 [Q] COG2015 Alkyl sulfatase and related hydrolases 4 8 8 9 |||---|||--------|------|-----|----------------------------------- 10 [C] COG2033 Desulfoferrodoxin 4 5 6 9 --|-------------------||------|-----||----------------------|-|-|- 10 [S] COG2155 Uncharacterized conserved protein 2 3 6 9 ----------------------||---------------------|--||||-||----------- 10 [C] COG2209 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE 3 6 8 9 -|----|||||||----|------------------------------------------------ 42 [S] COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN 4 5 5 9 ------||---------|||------||||------------------------------------ 9 [R] COG2251 Predicted nuclease (RecB family) 4 5 5 9 ------------------|--|--------------||-----------|---------||||--- 18 [S] COG2318 Uncharacterized protein conserved in bacteria 5 6 7 9 --||-------||-------|---------------|-------------------|||------- 9 [R] COG2404 Predicted phosphohydrolase (DHH superfamily) 3 4 6 9 ----||--|-|||---------------------|||----------------------------- 21 [S] COG2427 Uncharacterized conserved protein 5 7 7 9 -|--||-|---|-------|-------||-----------------------|------------- 42 [L] COG2452 Predicted site-specific integrase-resolvase 2 5 7 9 --|-|||||-|||----------------------------------------------------- 18 [S] COG2512 Uncharacterized membrane-associated protein/domain 1 2 5 9 ------------------------------------------|||||-||--|----------|-- 11 [E] COG2716 Glycine cleavage system regulatory protein 4 6 8 9 -------------|-------|--------------||-----------|--|--|------||-- 10 [K] COG2808 Transcriptional regulator 2 3 3 9 ----------------------------------|||-----||||-------||----------- 9 [P] COG2822 Predicted periplasmic lipoprotein involved in iron transport 1 4 5 9 --------------------------------------------------||-|||--||||---- 10 [S] COG2833 Uncharacterized protein conserved in bacteria 4 6 8 9 -------------------|-|-------------|------|-------|--||-----|--|-- 12 [S] COG2852 Uncharacterized protein conserved in bacteria 2 3 6 9 ----------------------||---------------------|--||||-||----------- 9 [C] COG2869 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC 2 3 6 9 ----------------------||---------------------|--||||-||----------- 9 [C] COG2871 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF 4 5 5 9 ---------------------|-----|||-|--------------------|------|||---- 9 [S] COG2899 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||--||||------------- 9 [R] COG2933 Predicted SAM-dependent methyltransferase 5 8 8 9 --|----------|||------||----------------------------|--|------|--- 22 [R] COG2940 Proteins containing SET domain 1 3 6 9 ------------------------------------------|||-|-||--|--|-------|-- 9 [M] COG2943 Membrane glycosyltransferase 2 3 5 9 ------------------||----------------------|||||-||---------------- 9 [E] COG2988 Succinylglutamate desuccinylase 3 3 5 9 --------------------|---------------||----|||-|-||---------------- 9 [E] COG3048 D-serine dehydratase 3 3 5 9 --------------------|----------||---------|||-|-|-|--------------- 10 [C] COG3051 Citrate lyase, alpha subunit 3 3 5 9 --------------------|----------||---------|||-|-|-|--------------- 10 [C] COG3052 Citrate lyase, gamma subunit 3 3 5 9 --------------------|----------||---------|||-|-|-|--------------- 10 [C] COG3053 Citrate lyase synthetase 1 2 4 9 ------------------------------------------|||-|-|-||----||-------- 9 [S] COG3059 Predicted membrane protein 1 2 7 9 ---------------------------------------------|--||||||||---------- 9 [NU] COG3063 Tfp pilus assembly protein PilF 1 1 4 9 ------------------------------------------|||||-|-|||------------- 12 [M] COG3065 Starvation-inducible outer membrane lipoprotein 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [P] COG3067 Na+/H+ antiporter 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [F] COG3072 Adenylate cyclase 2 2 4 9 ---|--------------------------------------|||||-|-||-------------- 9 [E] COG3075 Anaerobic glycerol-3-phosphate dehydrogenase 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [R] COG3081 Nucleoid-associated protein 1 1 4 9 ------------------------------------------|||||-||||-------------- 10 [R] COG3083 Predicted hydrolase of alkaline phosphatase superfamily 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [S] COG3089 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [S] COG3098 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [S] COG3100 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [S] COG3105 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 10 [T] COG3109 Activator of osmoprotectant transporter ProP 1 1 4 9 ------------------------------------------|||||-||||-------------- 18 [S] COG3111 Uncharacterized conserved protein 1 1 4 9 ------------------------------------------|||||-||||-------------- 10 [U] COG3114 Heme exporter protein D 1 2 4 9 ------------------------------------------|||||--|||---|---------- 10 [M] COG3133 Outer membrane lipoprotein 1 2 5 9 ------------------------------------------|||||-||--|--|---------- 9 [S] COG3147 Uncharacterized protein conserved in bacteria 1 2 5 9 ------------------------------------------|||||-||-|---|---------- 15 [R] COG3150 Predicted esterase 1 2 5 9 ------------------------------------------|||||-||--|--|---------- 9 [S] COG3164 Predicted membrane protein 3 6 7 9 ---||||||--||------------------------------------|---------------- 11 [S] COG3199 Uncharacterized conserved protein 3 5 7 9 -------------------|-----------------|----------||--------|||-||-- 12 [R] COG3211 Predicted phosphatase 2 4 7 9 ------------------------------|------------------|||-|||----|--|-- 11 [S] COG3220 Uncharacterized protein conserved in bacteria 2 4 5 9 ------------------||----------------------|||||--|-----|---------- 9 [S] COG3228 Uncharacterized protein conserved in bacteria 5 7 7 9 --------|-----------||-----|---------------------|-----|---||-|--- 15 [S] COG3246 Uncharacterized conserved protein 2 8 8 9 |||---||||--------||---------------------------------------------- 16 [C] COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit 2 8 8 9 ||||||--|||------------------------------------------------------- 20 [R] COG3269 Predicted RNA-binding protein, contains TRAM domain 2 3 5 9 |-|---------------------------------------|||||-||---------------- 9 [S] COG3272 Uncharacterized conserved protein 2 4 5 9 -------------------------------|----------|||||-|------|--------|- 10 [S] COG3274 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 10 [KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism 3 3 5 9 --------------------------|-----|---||----|||-|-|----------------- 20 [T] COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism 4 8 9 9 |||---|-|---|------------------|-----|----------|----------------- 87 [R] COG3291 FOG: PKD repeat 3 5 7 9 ------------------|-----------------|---------|--|-----|---||-||-- 12 [T] COG3300 MHYT domain (predicted integral membrane sensor domain) 3 3 5 9 --------|-||------------------------------|||-|---||-------------- 10 [P] COG3301 Formate-dependent nitrite reductase, membrane component 2 3 4 9 ----------------|-------------------------|||||---||----------|--- 19 [R] COG3302 DMSO reductase anchor subunit 5 7 7 9 -------------||----|-------|||----|--------------|---------|------ 15 [Q] COG3320 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes 4 4 4 9 ---------------------|----||||------||----------------------|-|--- 10 [S] COG3336 Predicted membrane protein 3 5 6 9 -------------------|---------------|-|----------|--|----||--|-|--- 9 [P] COG3338 Carbonic anhydrase 5 7 8 9 --|-||----|------|-|-------------------------|-----|------|------- 10 [S] COG3350 Uncharacterized conserved protein 6 7 9 9 -----------------|||-|--|-----|-----------------||--|------------- 16 [KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain 2 4 5 9 ------------------||----------------------|||-|--|----------|-|--- 12 [T] COG3447 Predicted integral membrane sensor domain 1 3 5 9 -------------------------------------------||||-||-----|---|--|--- 16 [S] COG3455 Uncharacterized protein conserved in bacteria 3 5 6 9 -----------------|------------|----|---------|--|----------||||--- 9 [G] COG3459 Cellobiose phosphorylase 2 3 5 9 -------------||--------------------------------------------||||||| 21 [C] COG3474 Cytochrome c2 5 7 8 9 ---|----------|----|-----------------|-------|---|-----|----|-|--- 11 [Q] COG3486 Lysine/ornithine N-monooxygenase 3 3 5 9 ----------------|---|--------------------------------------||||||| 9 [S] COG3494 Uncharacterized protein conserved in bacteria 4 4 5 9 -------------------|-|-----||------------------------------|||||-- 9 [S] COG3502 Uncharacterized protein conserved in bacteria 1 3 5 9 -------------------------------------------||||-||-----|---|--|--- 22 [S] COG3515 Uncharacterized protein conserved in bacteria 1 3 5 9 -------------------------------------------||||-||-----|---|--|--- 15 [S] COG3516 Uncharacterized protein conserved in bacteria 1 3 5 9 -------------------------------------------||||-||-----|---|--|--- 16 [S] COG3517 Uncharacterized protein conserved in bacteria 1 3 5 9 -------------------------------------------||||-||-----|---|--|--- 14 [S] COG3518 Uncharacterized protein conserved in bacteria 1 3 5 9 -------------------------------------------||||-||-----|---|--|--- 13 [S] COG3519 Uncharacterized protein conserved in bacteria 1 3 5 9 -------------------------------------------||||-||-----|---|--|--- 15 [S] COG3520 Uncharacterized protein conserved in bacteria 1 3 5 9 -------------------------------------------||||-||-----|---|--|--- 15 [S] COG3522 Uncharacterized protein conserved in bacteria 1 3 5 9 -------------------------------------------||||-||-----|---|--|--- 15 [S] COG3523 Uncharacterized protein conserved in bacteria 3 4 5 9 -----------------|-------------------|-----||-|------------||-||-- 10 [S] COG3533 Uncharacterized protein conserved in bacteria 4 5 7 9 -------------|----|--------------||--------------------|---||-||-- 9 [S] COG3542 Uncharacterized conserved protein 4 5 6 9 ----------|--------|----------|-----||-----||-|--|---------------- 15 [P] COG3546 Mn-containing catalase 1 2 3 9 -------------------------------|||||||||-------------------------- 9 [J] COG3557 Uncharacterized domain/protein associated with RNAses G and E 3 4 5 9 ---------------------------||----|------------------|------|||||-- 9 [H] COG3572 Gamma-glutamylcysteine synthetase 4 5 7 9 -------------------|-|---------|-|-----------|--|----------|--||-- 9 [S] COG3575 Uncharacterized protein conserved in bacteria 5 7 7 9 ---------------|--|-|---------|---|-----------------|------||-|--- 9 [G] COG3588 Fructose-1,6-bisphosphate aldolase 2 5 6 9 |--|-----|--------------------------------------||---------||||--- 15 [R] COG3608 Predicted deacylase 2 3 4 9 -------------------|----------------------||||---|---------||-|--- 11 [P] COG3624 Uncharacterized enzyme of phosphonate metabolism 2 3 4 9 -------------------|----------------------||||---|---------||-|--- 11 [P] COG3625 Uncharacterized enzyme of phosphonate metabolism 2 3 4 9 -------------------|----------------------||||---|---------||-|--- 11 [P] COG3626 Uncharacterized enzyme of phosphonate metabolism 2 3 4 9 -------------------|----------------------||||---|---------||-|--- 11 [P] COG3627 Uncharacterized enzyme of phosphonate metabolism 2 3 4 9 ---|----|----------------------|||||||---------------------------- 13 [S] COG3679 Uncharacterized conserved protein 2 3 4 9 --------------------------------||||------|||-|---------------|--- 10 [G] COG3684 Tagatose-1,6-bisphosphate aldolase 2 3 4 9 -------------------|----------------------|||-|--|---------||-|--- 23 [S] COG3685 Uncharacterized protein conserved in bacteria 1 2 3 9 ------------------------------------------||||---|---------||||--- 11 [P] COG3709 Uncharacterized component of phosphonate metabolism 2 2 3 9 -------------------------------||-||||----|||--------------------- 10 [L] COG3723 Recombinational DNA repair protein (RecE pathway) 1 3 4 9 ----------------------------------------------------|---||-||||-|| 16 [U] COG3736 Type IV secretory pathway, component VirB8 1 3 5 9 ----------------------------------------------------||||---|||||-- 9 [S] COG3737 Uncharacterized conserved protein 2 4 5 9 ------------------------------------||----|||-|--------|---|---|-- 10 [S] COG3766 Predicted membrane protein 2 4 6 9 --------------|-------------------------------|--|-----|---|||||-- 43 [S] COG3791 Uncharacterized conserved protein 5 5 6 9 --|-------|------|--|--------------------------------------|||||-- 10 [C] COG3808 Inorganic pyrophosphatase 3 4 5 9 --|------------------|--------|||-||||---------------------------- 11 [P] COG3853 Uncharacterized protein involved in tellurite resistance 1 3 4 9 ------------------------------||||||||-|-------------------------- 9 [T] COG3887 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain 1 3 4 9 -------------------------------------------------------|||||||||-- 9 [L] COG3893 Inactivated superfamily I helicase 2 3 4 9 -----------------|------------||||||||---------------------------- 9 [S] COG3906 Uncharacterized protein conserved in bacteria 4 7 7 9 --------------|---||----------||-----------------|----------|||--- 13 [G] COG3957 Phosphoketolase 2 3 5 9 -------------------------------||--|------|||-|--|-----|---------- 12 [R] COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase 2 3 4 9 -------------------|----------------------|||||-|----||----------- 9 [E] COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase 2 3 4 9 -------------------|----------------------||||---|---------||-|--- 11 [P] COG4107 ABC-type phosphonate transport system, ATPase component 2 4 5 9 -------------------|----------------------|||-|--|-----|-----||--- 9 [C] COG4117 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) 1 2 3 9 ------------------------------------------|||||-|----------|-||--- 9 [P] COG4150 ABC-type sulfate transport system, periplasmic component 3 4 5 9 -||----------------------------|-|||||-------------------------|-- 9 [R] COG4152 ABC-type uncharacterized transport system, ATPase component 2 3 4 9 --------------------|---------||||||||---------------------------- 11 [S] COG4224 Uncharacterized protein conserved in bacteria 3 4 6 9 ----------|||-----||------||||------------------------------------ 12 [S] COG4243 Predicted membrane protein 2 4 4 9 ---------------------|--------------------|||||--------|---||----- 9 [S] COG4269 Predicted membrane protein 3 5 6 9 --------------------|---------|----|------|||-|--|-----|---------- 9 [E] COG4302 Ethanolamine ammonia-lyase, small subunit 3 5 6 9 --------------------|---------|----|------|||-|--|-----|---------- 9 [E] COG4303 Ethanolamine ammonia-lyase, large subunit 1 3 6 9 ----------------------------------------------------||||---|||-|-| 9 [S] COG4391 Uncharacterized protein conserved in bacteria 3 4 6 9 ---------------------|---------|-|||-|----------||-----|---------- 10 [S] COG4392 Predicted membrane protein 2 3 4 9 ------------------------------||-|-|||-----|-||------------------- 9 [S] COG4405 Uncharacterized protein conserved in bacteria 4 4 5 9 ---------------------|----|||--|---------------------------||-||-- 10 [S] COG4420 Predicted membrane protein 2 4 4 9 --------------------------------||----|-||--------------|||---|--- 11 [S] COG4487 Uncharacterized protein conserved in bacteria 3 3 5 9 --------------------------|-----|---||----|||-|-|----------------- 19 [KT] COG4565 Response regulator of citrate/malate metabolism 1 3 6 9 ----------------------------------------------|--|-|---|---|||||-- 18 [T] COG4566 Response regulator 3 3 4 9 ----------------|--------------||-|||-----|||--------------------- 22 [L] COG4570 Holliday junction resolvase 1 3 3 9 ------------------------------------------|||||--------|---||-|--- 12 [G] COG4573 Predicted tagatose 6-phosphate kinase 4 6 6 9 -------------|||--||------||||------------------------------------ 16 [L] COG4581 Superfamily II RNA helicase 2 3 6 9 --------------------|---------------------||||--||-|--------|----- 9 [R] COG4589 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase 2 3 4 9 -------------------|----------------------|||---|----------||||--- 9 [E] COG4597 ABC-type amino acid transport system, permease component 2 3 6 9 ----------------|----------------------------|---|---------||-|||| 18 [R] COG4618 ABC-type protease/lipase transport system, ATPase and permease components 1 1 4 9 ------------------------------------------|||||-||||-------------- 10 [M] COG4623 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein 2 4 5 9 ----------------------||-------------------||||--|-----|------|--- 13 [U] COG4669 Type III secretory pathway, lipoprotein EscJ 1 4 6 9 ------------------------------------------------|-----|||||-|-||-- 12 [O] COG4736 Cbb3-type cytochrome oxidase, subunit 3 1 3 5 9 ------------------------------------------|||||-||--------||------ 19 [P] COG4771 Outer membrane receptor for ferrienterochelin and colicins 1 1 3 9 ------------------------------------------|||||||-||-------------- 9 [K] COG4776 Exoribonuclease II 2 3 4 9 -------------------|----------------------||||---|---------||-|--- 11 [P] COG4778 ABC-type phosphonate transport system, ATPase component 2 3 5 9 --------------------------|---------------|||||-||---------|------ 10 [P] COG4779 ABC-type enterobactin transport system, permease component 1 2 4 9 ------------------------------------------||||||||-----|---------- 9 [N] COG4787 Flagellar basal body rod protein 2 4 5 9 ----------------------||-------------------||||--|-----|------|--- 13 [U] COG4789 Type III secretory pathway, component EscV 2 4 5 9 ----------------------||-------------------||||--|-----|------|--- 15 [U] COG4791 Type III secretory pathway, component EscT 2 4 5 9 ----------------------||-------------------||||--|-----|------|--- 13 [U] COG4794 Type III secretory pathway, component EscS 2 3 3 9 --------------------------|||||---||||---------------------------- 32 [S] COG4842 Uncharacterized protein conserved in bacteria 2 4 4 9 --------------------------|---------------|||||--------|---||----- 9 [S] COG4950 Uncharacterized protein conserved in bacteria 3 5 6 9 ------------------||-|--------||--||||---------------------------- 9 [R] COG4956 Integral membrane protein (PIN domain superfamily) 3 5 8 9 ------------------||-|--------------------------||--||||---------- 9 [NU] COG4972 Tfp pilus assembly protein, ATPase PilM 1 3 5 9 -------------------------------------------||----|-----|---|||||-- 45 [K] COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain 2 3 3 9 ---------------------------||-------------|||||-------------||---- 11 [S] COG5383 Uncharacterized protein conserved in bacteria 1 2 3 9 ------------------------------------------|||-|--|---------||||--- 20 [S] COG5457 Uncharacterized conserved small protein 1 3 4 9 -------------------------------------------|-||--|-----|---||||--- 10 [S] COG5487 Small integral membrane protein 3 3 4 9 ---------------------------||--|--||------|||-|------------------- 11 [R] COG5562 Phage envelope protein