y a o g gggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggg 8 11 12 16 -----||----|-||--|||-------||--|||-|-|----|----------------------- 22 [G] COG0383 Alpha-mannosidase 6 9 11 16 ---|----|----||---|-|-----|---------------|||||--|---------|-|-|-- 19 [C] COG0427 Acetyl-CoA hydrolase 5 8 10 16 ---|---------||---||------|---------------|||-|-||---------||||--- 18 [O] COG0435 Predicted glutathione S-transferase 3 7 11 16 -------------||---||-------------------------|--|-||-|||---|||||-- 20 [O] COG0678 Peroxiredoxin 5 7 10 16 ------------------|-|-----|-------|-------|||||-|||--||-||-------- 19 [E] COG0786 Na+/glutamate symporter 3 7 9 16 -------------||---------------||--|||-----|||||--|-----|||-------- 54 [E] COG0833 Amino acid transporters 5 10 11 16 --|-|||||-|-|---|-----------------|-||-----------|-----|----|-|--- 18 [O] COG1030 Membrane-bound serine protease (ClpP class) 7 12 14 16 --------|----||---||-|----|---|---|-||-|--------||--|--|---------- 24 [R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [R] COG1084 Predicted GTPase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [R] COG1094 Predicted RNA-binding protein (contains KH domains) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [K] COG1095 DNA-directed RNA polymerase, subunit E' 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [R] COG1163 Predicted GTPase 8 11 12 16 -|------|----|||-|--||--------|||||||-----------|----------------- 17 [C] COG1227 Inorganic pyrophosphatase/exopolyphosphatase 5 13 13 16 ||||||--||--------||-|----|||--------------------|-----|---------- 22 [H] COG1239 Mg-chelatase subunit ChlI 4 12 14 16 ||||||||||||||||-------------------------------------------------- 45 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog 7 10 12 16 --||----|-|||---||||--||--||||------------------------------------ 16 [S] COG1259 Uncharacterized conserved protein 7 10 12 16 |-|---|||-||||--||--------||||------------------------------|----- 19 [I] COG1260 Myo-inositol-1-phosphate synthase 5 5 7 16 ---------------------|--||||||------||---------------------||||||| 17 [K] COG1329 Transcriptional regulators, similar to M. xanthus CarD 8 12 12 16 -|--||||-|--||--|-||-|-----|||------|----------------------------- 77 [L] COG1372 Intein/homing endonuclease 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG1383 Ribosomal protein S17E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [U] COG1400 Signal recognition particle 19 kDa protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 39 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module 4 7 11 16 ----------------|---|-||------------------|||||-||--|--|--|---||-- 30 [NU] COG1450 Type II secretory pathway, component PulD 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1471 Ribosomal protein S4E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1500 Predicted exosome subunit 5 8 12 16 -----------------|||----|------|----||----|||----|-|---|-----|||-- 23 [R] COG1512 Beta-propeller domains of methanol dehydrogenase type 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [R] COG1537 Predicted RNA-binding proteins 4 11 13 16 |||||||||||||--------------||----------------------------------|-- 48 [R] COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG1552 Ribosomal protein L40E 6 9 10 16 ------|------|-----|-------|||||---||--|--|||--------||----------- 22 [G] COG1554 Trehalose and maltose hydrolases (possible phosphorylases) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain 5 9 12 16 -------------||--|--------|---|-|||-||-----||---|--|---|---|------ 23 [G] COG1621 Beta-fructosidases (levanase/invertase) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG1631 Ribosomal protein L44E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1632 Ribosomal protein L15E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10) 4 6 9 16 -------------------|-------||-------||----|||||-||||---|--|------- 16 [S] COG1666 Uncharacterized protein conserved in bacteria 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [J] COG1676 tRNA splicing endonuclease 6 10 12 16 |-|-------------||--|---------|----|||--------|-||-----|---||-|--- 17 [S] COG1683 Uncharacterized conserved protein 8 11 12 16 ----------||-||---||-|||--|||||------|--------------|------------- 58 [T] COG1716 FOG: FHA domain 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG1717 Ribosomal protein L32E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG1727 Ribosomal protein L18E 4 12 14 16 |||||||||||||||-|------------------------------------------------- 17 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1736 Diphthamide synthase subunit DPH2 5 7 9 16 ------------------||-|---|||||----------------------|------||||||| 16 [R] COG1754 Uncharacterized C-terminal domain of topoisomerase IA 4 12 14 16 ||||||||||||||||-------------------------------------------------- 20 [K] COG1761 DNA-directed RNA polymerase, subunit L 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1798 Diphthamide biosynthesis methyltransferase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1 5 11 13 16 --||--|||--------|-------|----|-----||----------||-----|---||--|-- 17 [NT] COG1871 Chemotaxis protein; stimulates methylation of MCP proteins 4 6 10 16 ------------------||----||----||||-|||-------|--|-|||------------- 18 [M] COG1876 D-alanyl-D-alanine carboxypeptidase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1889 Fibrillarin-like rRNA methylase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG1890 Ribosomal protein S3AE 3 6 8 16 -----------------|------------||-|--||----|||||-|---------||||---- 16 [E] COG1897 Homoserine trans-succinylase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases) 4 7 10 16 -----------||||---------------------|-----|||||--|-----|----||||-- 25 [FH] COG1953 Cytosine/uracil/thiamine/allantoin permeases 3 5 8 16 -------------------|------------|-|-||----|||||-|-||----||-----|-- 29 [F] COG1972 Nucleoside permease 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1976 Translation initiation factor 6 (eIF-6) 4 8 11 16 ||--||--|||||------------------------|----|||||-|----------------- 16 [S] COG1986 Uncharacterized conserved protein 4 12 14 16 |||||||||||||||---------------|----------------------------------- 16 [K] COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1997 Ribosomal protein L37AE/L43A 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2004 Ribosomal protein S24E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [J] COG2007 Ribosomal protein S8E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG2016 Predicted RNA-binding protein (contains PUA domain) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG2051 Ribosomal protein S27E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2053 Ribosomal protein S28E/S33 4 12 14 16 ||||||||||||||||-------------------------------------------------- 24 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2 6 9 10 16 -------------||---|--|----||||------||-----------|-----|---||-||-- 50 [P] COG2072 Predicted flavoprotein involved in K+ transport 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [J] COG2075 Ribosomal protein L24E 4 8 10 16 -------------||---||----------|---|-||----|||-|---|||--|---------- 22 [H] COG2091 Phosphopantetheinyl transferase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG2097 Ribosomal protein L31E 6 11 12 16 ||----------------|||------||-|----|----------|--|-----|---||||--- 16 [H] COG2099 Precorrin-6x reductase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 28 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [R] COG2102 Predicted ATPases of PP-loop superfamily 7 10 11 16 --|----------|||--||----|-||||-------------------|---------||-||-- 102 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2125 Ribosomal protein S6E (S10) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2139 Ribosomal protein L21E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2147 Ribosomal protein L19E 2 4 7 16 ------------------------------|--|||||-||-|||||||--|-------------- 20 [G] COG2213 Phosphotransferase system, mannitol-specific IIBC component 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [L] COG2219 Eukaryotic-type DNA primase, large subunit 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2238 Ribosomal protein S19E (S16A) 3 4 8 16 ----------------|-------|-----------------|||||||-|||------||-||-- 16 [J] COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) 5 7 8 16 -------------||-|---------|||||----|||---------------------|||||-- 17 [R] COG2270 Permeases of the major facilitator superfamily 7 9 10 16 ---|--|--|--|---|----|---|-------|||||---------------------||||--- 24 [E] COG2309 Leucyl aminopeptidase (aminopeptidase T) 5 9 11 16 --|---------------||-|----|||-------------------||-----|--||||||-- 24 [S] COG2326 Uncharacterized conserved protein 5 7 8 16 ------------------|--|----||||----|-||-----------------|--||||||-- 20 [R] COG2346 Truncated hemoglobins 4 7 9 16 --------------|------|--------------||----|||-|--|-----|--||||||-- 17 [R] COG2351 Transthyretin-like protein 6 8 9 16 ------------------||||-----||||||||||----------------------||----- 24 [V] COG2367 Beta-lactamase class A 4 5 9 16 ------||--|||-------|---------------------|||||-|-||-||----------- 16 [S] COG2431 Predicted membrane protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 32 [R] COG2520 Predicted methyltransferase 6 6 10 16 ---|------|||-----------|----|-||---------|||||-|-||-------------- 20 [F] COG2820 Uridine phosphorylase 3 6 9 16 --------------------------|||--|-|---|-|--|||--------|||---||--|-- 66 [L] COG2826 Transposase and inactivated derivatives, IS30 family 7 10 12 16 -------------------|||---|-||-|--|||||--------------||-|-----|---- 19 [E] COG2856 Predicted Zn peptidase 5 8 10 16 --|----------||---|-----------------||----|||||--|---|||-------|-- 19 [E] COG2866 Predicted carboxypeptidase 1 3 7 16 ------------------------------------------|||||-|||||||----||||--- 16 [S] COG2900 Uncharacterized protein conserved in bacteria 3 5 9 16 -------------------|--||------------------|||||||||||--|-------|-- 16 [S] COG2912 Uncharacterized conserved protein 6 8 10 16 ----------------|---|-||--|-----||--------------||-----|---||||-|| 17 [R] COG2984 ABC-type uncharacterized transport system, periplasmic component 1 3 7 16 ------------------------------------------|||||-|-||----|||-||||-| 18 [P] COG3004 Na+/H+ antiporter 1 3 8 16 ------------------------------------------|||||-||||-|||----||||-- 16 [S] COG3024 Uncharacterized protein conserved in bacteria 1 3 9 16 ------------------------------------------|||||-||-||--|---|-||||| 19 [M] COG3047 Outer membrane protein W 2 2 6 16 -------------------------------|||||||----|||||-||||-------------- 16 [S] COG3091 Uncharacterized protein conserved in bacteria 5 8 11 16 --||-----------------|-----||--|---|||-----------|-----|---||-||-| 24 [R] COG3173 Predicted aminoglycoside phosphotransferase 5 7 9 16 --|----------------|-------||--|--||------||||---|-----|----|||--- 22 [S] COG3247 Uncharacterized conserved protein 4 9 11 16 -||-||---|-|----|-------------------------|||-|--|||------|-|----- 17 [J] COG3276 Selenocysteine-specific translation elongation factor 7 10 12 16 --|----------|----|||------||-|---|--|----|--||-||----------|----- 47 [L] COG3344 Retron-type reverse transcriptase 7 11 12 16 -||-||-----|-||----|------|||-|------------------------|---|--||-- 25 [G] COG3387 Glucoamylase and related glycosyl hydrolases 4 7 8 16 ------------------||-|----||||||||||||-|-------------------------- 27 [D] COG3599 Cell division initiation protein 1 3 6 16 ------------------------------------------|||||---||-||----||||||| 77 [M] COG3637 Opacity protein and related surface antigens 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [T] COG3642 Mn2+-dependent serine/threonine protein kinase 4 6 10 16 -------------------|-|-----||--------------|||--||--|--|---|||||-- 54 [R] COG3668 Plasmid stabilization system protein 5 10 11 16 -||-----|||---------------||||||-|-|-------------|---||----------- 17 [T] COG3830 ACT domain-containing protein 5 8 9 16 --|--------------|--------|||-|---||||-----------|-----|---||-||-- 43 [S] COG3832 Uncharacterized conserved protein 7 8 11 16 --------|-------|--|-|----|---------||----|||||-||--|--|---------- 16 [R] COG4147 Predicted symporter 6 6 9 16 --|--------------|--|---||---------|------||||||||||-------------- 17 [C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC 5 8 9 16 ---||-----|-|-------|-------------||-|----|||-|--------|----|||--- 18 [I] COG4670 Acyl CoA:acetate/3-ketoacid CoA transferase 2 3 7 16 -------------------------------|--||||----|||||-|-||-------|-|-|-- 16 [CO] COG4987 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components 4 12 14 16 ||||||||||||||||-------------------------------------------------- 26 [J] COG5256 Translation elongation factor EF-1alpha (GTPase) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) 4 6 9 16 --|-----------------|----------------|-----||||---||||||----|||--- 25 [UW] COG5295 Autotransporter adhesin