y a o g gggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggg 3 3 7 12 -------------|------------|---------------|||||-|||||------------- 14 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase 2 5 7 12 ------------------||----------------------------||||----|||||-|--- 14 [P] COG0748 Putative heme iron utilization protein 2 4 6 12 ------------------|-----------------------|||||---|-----||||---|-- 21 [E] COG0754 Glutathionylspermidine synthase 4 5 7 12 -------------|||------||------------------|||||-||---------------- 13 [O] COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like 2 10 10 12 ||||||||||---||--------------------------------------------------- 13 [L] COG1111 ERCC4-like helicases 2 9 10 12 ||||||||||-||----------------------------------------------------- 12 [S] COG1303 Uncharacterized protein conserved in archaea 5 10 11 12 |||---|||||-|---||------------|----------------------------------- 13 [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins 5 6 7 12 ----------------|-||------||||------||---------------|||---------- 12 [O] COG1333 ResB protein required for cytochrome c biosynthesis 5 10 11 12 |||--||--|||-----|-|-------||------------------------------------- 17 [L] COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 2 8 10 12 |-|||||||||||----------------------------------------------------- 13 [S] COG1340 Uncharacterized archaeal coiled-coil protein 4 8 10 12 |-|-|||||-|||---||------------------------------------------------ 15 [R] COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) 3 10 11 12 ||||--||||-||||--------------------------------------------------- 12 [J] COG1369 RNase P/RNase MRP subunit POP5 3 7 9 12 |---|||||||||-----------------------------------------------|-|--- 13 [S] COG1415 Uncharacterized conserved protein 4 5 6 12 ---------------------|---|-----||-|||-||||-------------|---------- 16 [F] COG1428 Deoxynucleoside kinases 5 9 10 12 -||-||||--||----|-||----|----------------------------------------- 19 [G] COG1449 Alpha-amylase/alpha-mannosidase 4 9 9 12 ||||----||------------||---|||--|--------------------------------- 13 [S] COG1478 Uncharacterized conserved protein 2 8 10 12 |-|||||||||||----------------------------------------------------- 17 [S] COG1602 Uncharacterized conserved protein 3 10 11 12 ||||--||||-||||--------------------------------------------------- 12 [J] COG1603 RNase P/RNase MRP subunit p30 5 7 8 12 -------------|||---|----||----------------|||-|--|-----|---------- 17 [G] COG1626 Neutral trehalase 2 8 10 12 -||||||||||||----------------------------------------------------- 12 [S] COG1650 Uncharacterized protein conserved in archaea 2 9 11 12 ||||||-||||||----------------------------------------------------- 12 [EH] COG1685 Archaeal shikimate kinase 2 8 10 12 -||||||||||||----------------------------------------------------- 12 [K] COG1709 Predicted transcriptional regulator 5 7 7 12 -----------|---------|-----||------|-|-||-|---|------------|--|--- 13 [R] COG1735 Predicted metal-dependent hydrolase with the TIM-barrel fold 5 7 7 12 --|-----|-------|--|----------|-----------|||-|---------|||------- 21 [C] COG1740 Ni,Fe-hydrogenase I small subunit 4 5 6 12 ---------------------|-----||---|||-||------------||-||----------- 12 [S] COG1755 Uncharacterized protein conserved in bacteria 5 8 8 12 |-|-||-------||-|----|------------||||---------------------------- 12 [L] COG1796 DNA polymerase IV (family X) 3 6 9 12 ------------------||--||---------------------|--||||-||-------|--- 12 [C] COG1805 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB 6 7 7 12 --------|--------|--||--------|----|||----|||-|------------------- 13 [R] COG1811 Uncharacterized membrane protein, possible Na+ channel or pump 3 4 6 12 -------------------------|--------|-|-----|||||-|-||------|------- 13 [R] COG1823 Predicted Na+/dicarboxylate symporter 2 9 10 12 |||||||||||-|----------------------------------------------------- 12 [R] COG1831 Predicted metal-dependent hydrolase (urease superfamily) 3 10 11 12 ||||-|||||||-----|------------------------------------------------ 12 [S] COG1833 Uncharacterized conserved protein 6 9 9 12 --|---------|-----||-------||-|-----||-----------|----------|-|--- 14 [E] COG1834 N-Dimethylarginine dimethylaminohydrolase 2 8 10 12 |||-|||||||||----------------------------------------------------- 12 [S] COG1909 Uncharacterized protein conserved in archaea 5 8 8 12 --|-||----------|--|-------||--------------------------|||--|-|--- 16 [R] COG1926 Predicted phosphoribosyltransferases 4 6 7 12 -----------------||||---------||||||||---------------------------- 12 [S] COG1939 Uncharacterized protein conserved in bacteria 2 9 9 12 ||||||||||------------||------------------------------------------ 15 [S] COG1945 Uncharacterized conserved protein 3 8 10 12 ||--|||||||||---|------------------------------------------------- 12 [G] COG1980 Archaeal fructose 1,6-bisphosphatase 7 8 9 12 |--|-------------|--|---|||-----|||--|----------|----------------- 12 [S] COG2035 Predicted membrane protein 6 11 11 12 ||--||---|-------|||-|--------|-----|------------------|---------- 12 [HR] COG2045 Phosphosulfolactate phosphohydrolase and related enzymes 4 9 11 12 |||---|||||||---|-------------------------------------------|----- 15 [R] COG2129 Predicted phosphoesterases, related to the Icc protein 3 4 6 12 ---------------------------||-----|-||----|||-|--|------------||-- 14 [Q] COG2162 Arylamine N-acetyltransferase 3 3 6 12 |----------------|------------------------||||||||||-------------- 12 [P] COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur 4 6 7 12 ---|--------------||------|||-------------|||-|--|-----|---------- 12 [S] COG2170 Uncharacterized conserved protein 4 7 8 12 ------------------|||---------||----|-----|||||----------------|-- 42 [G] COG2211 Na+/melibiose symporter and related transporters 4 6 8 12 ------------------||------|----|----||----|||-|--|------------|--- 14 [S] COG2268 Uncharacterized protein conserved in bacteria 5 7 8 12 -------------||--|---------||-|-----||---------------------||-||-- 22 [G] COG2273 Beta-glucanase/Beta-glucan synthetase 5 7 8 12 -----------|------|--|-----|||-------------------|-----|---||-||-- 19 [S] COG2308 Uncharacterized conserved protein 5 6 7 12 ---|-----------------|----|---------||----|||||-----|----------|-- 20 [S] COG2311 Predicted membrane protein 6 8 8 12 |----------------|||-|--------|-----------|||-|------------|-|---- 14 [S] COG2327 Uncharacterized conserved protein 6 8 9 12 --|----------||---||-|-----||------------------------------||-||-- 23 [M] COG2335 Secreted and surface protein containing fasciclin-like repeats 5 6 7 12 ---|--||-----------|-|----|-----||||||---------------------------- 14 [S] COG2339 Predicted membrane protein 6 7 8 12 ----||------------||-|----||||-------|-------|--|----------------- 19 [K] COG2345 Predicted transcriptional regulator 5 8 11 12 -------------||------|-----||--|---|---------|---|-----|---|---|-- 19 [T] COG2365 Protein tyrosine/serine phosphatase 4 5 6 12 ---------------------|----|---|---||||----|||-|--|---------------- 17 [P] COG2382 Enterochelin esterase and related enzymes 3 5 8 12 -||------||||-----------------------------|||||-|----------------- 15 [R] COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain 4 5 6 12 --------------------|---|-------||----|---|||||---||-------------- 12 [E] COG2502 Asparagine synthetase A 3 8 9 12 ||----||-|---------|-------------------------|---|---||----|-|---- 12 [S] COG2510 Predicted membrane protein 2 3 5 12 ------------------------------|-----------|||||-|-||----|||------- 21 [R] COG2704 Anaerobic C4-dicarboxylate transporter 2 4 5 12 --------------------|---------|||||||||||------------------------- 12 [S] COG2739 Uncharacterized protein conserved in bacteria 3 7 10 12 ---------------------|--------|--|--|------||-|--|---|----||---|-- 13 [R] COG2819 Predicted hydrolase of the alpha/beta superfamily 2 5 7 12 ------------------------------|---|-------|||||---|--|||----|----- 12 [D] COG2846 Regulator of cell morphogenesis and NO signaling 2 5 9 12 ---------------------|-----------------------|--||-|-||||||-|----- 21 [C] COG2863 Cytochrome c553 3 3 6 12 --------|-|-------------------------------||||||||||-------------- 12 [P] COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit 1 2 6 12 ------------------------------------------|||||||||||--|---------- 12 [L] COG2925 Exonuclease I 2 6 9 12 -------------||---------------------------------||--|--|--||||||-- 12 [O] COG2935 Putative arginyl-tRNA:protein arginylyltransferase 1 2 6 12 ------------------------------------------|||||-|-||||||---------- 12 [G] COG2956 Predicted N-acetylglucosaminyl transferase 1 2 6 12 ------------------------------------------|||||-||||-|||---------- 12 [H] COG2959 Uncharacterized enzyme of heme biosynthesis 3 5 8 12 --------------------|---------|-||||||----------||--|--|---------- 33 [T] COG2972 Predicted signal transduction protein with a C-terminal ATPase domain 1 4 6 12 ------------------------------------------|||||-|-||-||---|---|--- 15 [S] COG2990 Uncharacterized protein conserved in bacteria 1 3 6 12 ------------------------------------------|||||-||||------|||----- 26 [C] COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit 1 2 6 12 ------------------------------------------|||||-||||-|||---------- 19 [R] COG3008 Paraquat-inducible protein B 3 6 10 12 ------------------||--------------|-||-------|--||--|--|------||-- 12 [S] COG3011 Uncharacterized protein conserved in bacteria 3 5 8 12 -------------------|-------------|--------|||-|-|-|-|---||-|------ 14 [S] COG3041 Uncharacterized protein conserved in bacteria 1 3 6 12 ------------------------------------------|||||-||||------|||----- 12 [C] COG3043 Nitrate reductase cytochrome c-type subunit 1 3 6 12 ------------------------------------------|||||-||||------|||----- 12 [P] COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase 1 2 4 12 ------------------------------------------|||||-|-||-------||||--- 12 [R] COG3106 Predicted ATPase 1 2 6 12 ------------------------------------------|||||-|-||||||---------- 12 [R] COG3113 Predicted NTP binding protein (contains STAS domain) 1 2 6 12 ------------------------------------------|||||||||||--|---------- 12 [D] COG3116 Cell division protein 1 2 7 12 ------------------------------------------|||||-||-|||||---------- 12 [S] COG3165 Uncharacterized protein conserved in bacteria 2 4 7 12 ------------------|-----------------------|||||--|--|--|---|--|--| 70 [NU] COG3188 P pilus assembly protein, porin PapC 4 6 9 12 ----------||------|----------------|------|---|--|-----|---|-|||-- 16 [R] COG3193 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol 1 2 5 12 ------------------------------------------|||||||-||-|||---------- 67 [M] COG3203 Outer membrane protein (porin) 4 7 8 12 -------------------|-------||||-----||-------|---|-----|---|--|--- 19 [Q] COG3208 Predicted thioesterase involved in non-ribosomal peptide biosynthesis 3 6 7 12 --|---------------------------|----||-----|||||--|-----|------|--- 71 [M] COG3209 Rhs family protein 3 4 6 12 ---------------------|-----||-------------|||-|--|---------||-||-- 12 [S] COG3214 Uncharacterized protein conserved in bacteria 6 8 9 12 --|---------------||-|----||-----|---------------------|---|-|||-- 148 [L] COG3293 Transposase and inactivated derivatives 1 3 6 12 ------------------------------------------|||||-||-----|----||||-- 16 [R] COG3313 Predicted Fe-S protein 6 7 9 12 --|----------------||------|||------|-----------||-|--------|-|--- 55 [Q] COG3315 O-Methyltransferase involved in polyketide biosynthesis 5 8 10 12 -|-|----|-------|---------|-------||---------|------|--------|||-- 37 [L] COG3316 Transposase and inactivated derivatives 1 2 6 12 ------------------------------------------|||||-||||-|||---------- 12 [M] COG3317 Uncharacterized lipoprotein 4 7 7 12 -------------------|------|||||-----|--------|---------|---||-|--- 90 [Q] COG3321 Polyketide synthase modules and related proteins 7 9 9 12 --|-||||---|-|-----|-|---------------|----------------------|-|--- 21 [G] COG3408 Glycogen debranching enzyme 4 9 10 12 --||||||-|||----|-||---------------------------------------------- 17 [S] COG3431 Predicted membrane protein 4 6 7 12 -|-------|----------|---------||||||||----------------------|----- 15 [R] COG3481 Predicted HD-superfamily hydrolase 3 6 8 12 -------------------|----------|---------------|-----|--|||-||-|-|| 21 [U] COG3505 Type IV secretory pathway, VirD4 components 1 2 5 12 ------------------------------------------|||||-||---------|||||-- 12 [T] COG3605 Signal transduction protein containing GAF and PtsI domains 2 3 5 12 --------------------------------||-----||-|||||-|-||-------------- 14 [G] COG3623 Putative L-xylulose-5-phosphate 3-epimerase 2 4 7 12 -------------------------------||-|-|-----|||-|--|--|--|-------|-- 12 [O] COG3634 Alkyl hydroperoxide reductase, large subunit 5 7 9 12 --|----------------||---------|-|||--|-----------|---------||--|-- 67 [L] COG3666 Transposase and inactivated derivatives 2 5 8 12 ------------------||----------------------|||||-||----||----|----- 21 [UNTP] COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein 3 6 7 12 -------------||---------------------|-----|||----------|---|||||-- 14 [P] COG3703 Uncharacterized protein involved in cation transport 4 7 8 12 --------------------|------||||----|-------------|-----|---||-||-- 15 [T] COG3707 Response regulator with putative antiterminator output domain 2 4 6 12 ---------------------------||-------------|||||-|------|-----|||-- 13 [S] COG3714 Predicted membrane protein 3 5 6 12 --------------------------|--------|||-------||--------|---|||||-- 12 [G] COG3718 Uncharacterized enzyme involved in inositol metabolism 2 4 5 12 ------------------------------||||--------|||-------|------||||--- 23 [M] COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) 3 5 6 12 --------------------|-----------|---------||||---|-----|---||||--- 12 [S] COG3758 Uncharacterized protein conserved in bacteria 3 5 8 12 -------------------|----------|-----------|||||-----|--|------||-| 43 [R] COG3772 Phage-related lysozyme (muraminidase) 1 2 4 12 ------------------------------------------|||||-|-||-------||||--- 12 [H] COG3840 ABC-type thiamine transport system, ATPase component 1 2 6 12 ------------------------------------------|||||-||||-|||---------- 16 [T] COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific 3 5 6 12 --------------------------|--------|||-------||--------|---|||||-- 13 [E] COG3962 Acetolactate synthase 3 4 5 12 ---------------------|-----||-------------||||---|---------||||--- 12 [R] COG4106 Trans-aconitate methyltransferase 3 4 5 12 --------------------------|||-|-||||||---------------------|-|---- 21 [S] COG4129 Predicted membrane protein 1 2 7 12 ------------------------------------------|||||-||-|||||---------- 13 [R] COG4137 ABC-type uncharacterized transport system, permease component 1 2 5 12 ------------------------------------------|||||-||||-------||-|--- 26 [E] COG4160 ABC-type arginine/histidine transport system, permease component 1 3 6 12 ------------------------------------------|||||-||-----|---||-||-- 12 [Q] COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component 2 5 6 12 -------------------------------------|-|--||||----|----|---||||--- 18 [G] COG4213 ABC-type xylose transport system, periplasmic component 2 5 6 12 -------------------------------------|-|--||||----|----|---||||--- 17 [G] COG4214 ABC-type xylose transport system, permease component 1 2 5 12 ------------------------------------------|||||-||||-------||-|--- 26 [E] COG4215 ABC-type arginine transport system, permease component 1 2 5 12 ------------------------------------------|||||-||||-------|||---- 12 [P] COG4531 ABC-type Zn2+ transport system, periplasmic component/surface adhesin 3 6 8 12 --------------------------|------||-||-------|--|----||---||-|---- 12 [P] COG4604 ABC-type enterochelin transport system, ATPase component 3 6 8 12 --------------------------|------||-||-------|--|----||---||-|---- 12 [P] COG4605 ABC-type enterochelin transport system, permease component 3 6 8 12 --------------------------|------||-||-------|--|----||---||-|---- 12 [P] COG4606 ABC-type enterochelin transport system, permease component 3 6 8 12 --------------------------|------||-||-------|--|----||---||-|---- 14 [P] COG4607 ABC-type enterochelin transport system, periplasmic component 1 3 6 12 ------------------------------------------|||||-||--|--|----|||--- 12 [P] COG4651 Kef-type K+ transport system, predicted NAD-binding component 1 3 7 12 ------------------------------------------|||||-|||||--|-------|-- 16 [U] COG4795 Type II secretory pathway, component PulJ 3 5 8 12 ---------------------|----|---------------|||||-||-----|------||-- 14 [R] COG5006 Predicted permease, DMT superfamily