y a o g gggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggg 6 8 9 11 ---|------------|-||-|-----||--------------------|----------|-||-- 13 [R] COG0645 Predicted kinase 3 5 7 11 ------------------|-----------|-----||----|||-|-||-----|---------- 11 [S] COG0700 Uncharacterized membrane protein 3 4 6 11 ---------------------------||-------|-----|||||-||-----------|---- 11 [Q] COG1021 Peptide arylation enzymes 5 8 9 11 ------------------||-|----|||-------|------------|-----|------||-- 12 [E] COG1231 Monoamine oxidase 2 9 9 11 ||||||||||--------------------|----------------------------------- 11 [R] COG1244 Predicted Fe-S oxidoreductase 2 8 10 11 ||||--|||||||----------------------------------------------------- 12 [J] COG1325 Predicted exosome subunit 3 8 9 11 -||||||||-||-----|------------------------------------------------ 31 [M] COG1361 S-layer domain 7 8 8 11 -------------||--|--|----||||||------------------|---------------- 14 [E] COG1362 Aspartyl aminopeptidase 2 8 10 11 ||||--|||||||----------------------------------------------------- 11 [L] COG1389 DNA topoisomerase VI, subunit B 5 6 6 11 ---|---------|||----------|||-------------|||-|------------------- 11 [I] COG1443 Isopentenyldiphosphate isomerase 2 9 9 11 ||||||||||-|------------------------------------------------------ 12 [J] COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain 2 7 9 11 ||--|||||||||----------------------------------------------------- 15 [K] COG1581 Archaeal DNA-binding protein 2 9 9 11 ||||||||||--|----------------------------------------------------- 12 [J] COG1588 RNase P/RNase MRP subunit p29 4 8 10 11 |||---|||-|||---||------------------------------------------------ 15 [L] COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 2 8 9 11 |||-||||||-||----------------------------------------------------- 11 [S] COG1698 Uncharacterized protein conserved in archaea 2 8 10 11 ||||--|||||||----------------------------------------------------- 11 [S] COG1701 Uncharacterized protein conserved in archaea 2 8 10 11 ||||--|||||||----------------------------------------------------- 11 [R] COG1829 Predicted archaeal kinase (sugar kinase superfamily) 5 7 9 11 -|----|||-|||--------|-----||-------------------------------|----- 87 [R] COG1848 Predicted nucleic acid-binding protein, contains PIN domain 4 8 10 11 |||---|||-|||---|---|--------------------------------------------- 17 [L] COG1857 Uncharacterized protein predicted to be involved in DNA repair 4 6 9 11 ------||---------|------------|--|--||-------|------|-------|--|-- 15 [G] COG1874 Beta-galactosidase 2 7 9 11 ||--|||||||||----------------------------------------------------- 11 [S] COG1888 Uncharacterized protein conserved in archaea 3 9 9 11 ||||--||||--------------||--------------------------|------------- 11 [S] COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein) 2 8 10 11 ||||--|||||||----------------------------------------------------- 11 [S] COG1931 Uncharacterized protein conserved in archaea 5 6 6 11 ------------------||-|----||||-----|||-----------------|---------- 13 [S] COG1950 Predicted membrane protein 3 8 10 11 ||||--||-||||----|------------------------------------------------ 17 [S] COG1992 Uncharacterized conserved protein 5 8 9 11 -||---||-|------||---------||--------------------------------|-|-- 13 [S] COG1993 Uncharacterized conserved protein 3 7 9 11 ||--||||-||||------------------------------------------------|---- 12 [F] COG2019 Archaeal adenylate kinase 6 7 10 11 --------|---|-------|-----|-----|----|----|------||-----||-------- 12 [I] COG2031 Short chain fatty acids transporter 2 8 9 11 |||-||||||-||----------------------------------------------------- 12 [S] COG2034 Predicted membrane protein 3 10 10 11 ||||--||||---|||-------------------------------------------------- 40 [B] COG2036 Histones H3 and H4 5 8 8 11 -------------||---|--------||||-----|-----|----------------|--|--- 13 [E] COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) 4 10 10 11 ||||||---|-|-|||-------------------------------------------------- 11 [S] COG2042 Uncharacterized conserved protein 5 9 9 11 -||-----------------|---|-----|-----|----------------|--|||----|-- 13 [M] COG2089 Sialic acid synthase 3 8 10 11 |--|--|||||||||--------------------------------------------------- 12 [S] COG2106 Uncharacterized conserved protein 3 8 10 11 -|||--|||||||-----------------|----------------------------------- 11 [R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme 5 9 10 11 ---|---------||---||-------||-------------------||-----|-------|-- 16 [S] COG2119 Predicted membrane protein 4 8 8 11 --|---|||---------|-----------------|---------|--------|---||-|--- 14 [GR] COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes 4 8 10 11 ||----||-|||||||-------------------------------------------------- 13 [J] COG2174 Ribosomal protein L34E 4 5 6 11 -----------------|||-|---------|||||||---------------------------- 12 [R] COG2179 Predicted hydrolase of the HAD superfamily 5 8 9 11 --||||--|-||----|---|-------------|-|----------------------------- 22 [S] COG2210 Uncharacterized conserved protein 6 9 9 11 ||-------|---||-|----|-----||------------------------||----------- 12 [R] COG2229 Predicted GTPase 2 7 9 11 -||||||||-|||----------------------------------------------------- 12 [S] COG2237 Predicted membrane protein 5 8 8 11 --------------|------|----|||-|---|-|---------|--------|-------|-- 15 [I] COG2272 Carboxylesterase type B 4 5 6 11 ------------------||||---------|||||||---------------------------- 11 [S] COG2302 Uncharacterized conserved protein, contains S4-like domain 4 6 7 11 ------------------|--|-----|||-------------------|-----|---||-||-- 18 [S] COG2307 Uncharacterized protein conserved in bacteria 5 6 6 11 --------------|--|---|------------||------|||--------------||-|--- 11 [Q] COG2313 Uncharacterized enzyme involved in pigment biosynthesis 7 7 9 11 ------||---||-|--|-|---------------|-|----------------------|--|-- 11 [C] COG2421 Predicted acetamidase/formamidase 6 9 9 11 ------||-----||--|-|----------|-----||--------------|--|---------- 24 [G] COG2730 Endoglucanase 1 3 4 11 ------------------------------------------|||||----|-||-|||------- 11 [M] COG2829 Outer membrane phospholipase A 4 6 8 11 ---|---------------|----------|-----------------||---||||||------- 11 [S] COG2836 Uncharacterized conserved protein 1 4 6 11 ------------------------------------------|||----|-|-||-|||--|---- 11 [S] COG2841 Uncharacterized protein conserved in bacteria 2 5 7 11 -------------------------------|-|-||-----------||-----|--|||-|--- 11 [R] COG2910 Putative NADH-flavin reductase 1 1 5 11 ------------------------------------------|||||||||||------------- 11 [R] COG2915 Uncharacterized protein involved in purine metabolism 1 2 5 11 ------------------------------------------|||||||-|||--|---------- 23 [R] COG2916 DNA-binding protein H-NS 2 3 6 11 ------------------------------|----|------||||||||-|-------------- 11 [H] COG2918 Gamma-glutamylcysteine synthetase 4 7 8 11 --------------|---||-|---------------------------|--|--|---||||--- 11 [S] COG2947 Uncharacterized conserved protein 1 4 6 11 ----------------------------------------------------|--|||-||||||| 23 [U] COG2948 Type IV secretory pathway, VirB10 components 1 2 5 11 ------------------------------------------|||||-|-||-|||---------- 11 [L] COG2965 Primosomal replication protein N 7 8 8 11 ----||-----|-----|-|-|--------|-----------------|-----------|||--- 14 [G] COG2971 Predicted N-acetylglucosamine kinase 1 2 6 11 ------------------------------------------|||||-|||--|||---------- 12 [S] COG2975 Uncharacterized protein conserved in bacteria 4 4 6 11 ---|----------------|-----|---------------|||||-|-||-------------- 17 [R] COG2985 Predicted permease 1 2 5 11 ------------------------------------------|||||-|-||-|||---------- 18 [S] COG2995 Uncharacterized paraquat-inducible protein A 3 4 6 11 --------------------|---------||||||||----------||---------------- 11 [S] COG2996 Uncharacterized protein conserved in bacteria 4 5 7 11 ------------------||------|-------|-------|||||-|--|-------------- 11 [G] COG3001 Fructosamine-3-kinase 2 4 7 11 --------------------------|---------------|||-|-||--------||--||-- 16 [M] COG3040 Bacterial lipocalin 2 4 6 11 --------|---------------------------------|||||-|----|||------|--- 12 [R] COG3042 Putative hemolysin 1 2 6 11 ------------------------------------------|||||-|||||--|---------- 11 [T] COG3073 Negative regulator of sigma E activity 3 3 6 11 -----------------|--|---------------------|||||-||||-------------- 12 [T] COG3086 Positive regulator of sigma E activity 2 2 5 11 -----------------------------------||-----|||||-||||-------------- 15 [T] COG3103 SH3 domain protein 3 4 6 11 ---------------------|----|---------------|||-|-||----------|||--- 12 [Q] COG3135 Uncharacterized protein involved in benzoate metabolism 1 3 5 11 ------------------------------------------|||||-||-----|---|||---- 11 [I] COG3154 Putative lipid carrier protein 1 3 7 11 ------------------------------------------|||||-||-||--|-------|-- 11 [S] COG3159 Uncharacterized protein conserved in bacteria 3 3 5 11 ---------------------------||--|----------|||||--|||-------------- 11 [H] COG3172 Predicted ATPase/kinase involved in NAD metabolism 2 5 7 11 -------------||----------------------------------|-----|---||||||| 11 [O] COG3175 Cytochrome oxidase assembly factor 3 5 7 11 -------------------|-------||-------------------||-----|---|||||-- 14 [R] COG3176 Putative hemolysin 4 6 9 11 --------------------|-----|---------||--------|-||-|---|---||----- 21 [S] COG3181 Uncharacterized protein conserved in bacteria 2 4 5 11 -------------||---------------------------|||-|--|---------||||--- 13 [F] COG3194 Ureidoglycolate hydrolase 4 6 7 11 ---------------------|----|---------||-----------|-----|---|||||-- 12 [S] COG3195 Uncharacterized protein conserved in bacteria 1 4 7 11 ------------------------------------------------||---||||||-|-||-- 13 [P] COG3197 Uncharacterized protein, possibly involved in nitrogen fixation 1 3 6 11 ------------------------------------------|||||-||--|--|-----||--- 11 [S] COG3242 Uncharacterized protein conserved in bacteria 5 7 10 11 ----||--|-|||---|--------------------|-----------|------------||-- 17 [I] COG3255 Putative sterol carrier protein 2 3 5 11 --------------------------|||-------------|||||-|--|-----------|-- 11 [S] COG3304 Predicted membrane protein 1 4 6 11 ---------------------------------------------|----||-||-||-|-||--| 25 [M] COG3306 Glycosyltransferase involved in LPS biosynthesis 1 3 5 11 ------------------------------------------|||||-|---|--|----|||--- 25 [K] COG3311 Predicted transcriptional regulator 1 2 5 11 ------------------------------------------|||||-||||-||----------- 11 [C] COG3312 F0F1-type ATP synthase, subunit I 3 5 6 11 --------------------|---------|---|-||----|||-|-|-----------|----- 16 [S] COG3314 Uncharacterized protein conserved in bacteria 3 4 6 11 ----------------------||------------|-----|||-|-||---||----------- 12 [R] COG3318 Predicted metal-binding protein related to the C-terminal domain of SecA 1 2 3 11 -------------------------------|||||||||||------------------------ 13 [R] COG3331 Penicillin-binding protein-related factor A, putative recombinase 3 4 5 11 ----------------|-------------------||------------------||||||||-- 11 [S] COG3334 Uncharacterized conserved protein 6 8 8 11 ----|------|--|------------||-----|----------||--------|||-------- 11 [P] COG3376 High-affinity nickel permease 3 4 6 11 ---|-------|------------------------------|||||-|-||---|---------- 27 [R] COG3381 Uncharacterized component of anaerobic dehydrogenases 6 11 11 11 --||-|-----|------||-|---------------|----|------------|----|----- 183 [L] COG3385 FOG: Transposase and inactivated derivatives 4 5 6 11 --------------------||---------|-|||-|----|||-----------------|--- 12 [S] COG3412 Uncharacterized protein conserved in bacteria 3 4 6 11 ---------------------------||-------|-----|||||-||-----------|---- 11 [Q] COG3433 Aryl carrier domain 5 9 9 11 --||||-----|----|-------|---------------------|------||------|---- 14 [S] COG3439 Uncharacterized conserved protein 3 5 6 11 ------------------||------|||||||||------------------------------- 11 [R] COG3442 Predicted glutamine amidotransferase 2 3 4 11 -------------------------------||||-|-----|||-|------------|--|--- 11 [R] COG3443 Predicted periplasmic or secreted protein 2 5 6 11 ------------------------------|----|||----|||-|--------|------||-- 17 [L] COG3449 DNA gyrase inhibitor 2 4 7 11 --------------------------|------------------|---|-----|---||||||| 26 [Q] COG3485 Protocatechuate 3,4-dioxygenase beta subunit 1 4 6 11 ----------------------------------------------------|--|||-||||||| 25 [U] COG3504 Type IV secretory pathway, VirB9 components 3 5 6 11 ---------------------|------------|-||-----------|-----|---|||||-- 16 [R] COG3545 Predicted esterase of the alpha/beta hydrolase fold 3 5 7 11 ----------------|-------|-----------------|||-|-||-----|----|-|--- 21 [KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains 3 5 6 11 --------------------|---------|---||||-----------|-|-------||-|--- 22 [S] COG3708 Uncharacterized protein conserved in bacteria 3 4 5 11 ---------------------------||--------|----|||||-|-----------|-|--- 32 [K] COG3710 DNA-binding winged-HTH domains 1 2 4 11 ------------------------------------------|||-|---||-------|||||-- 12 [J] COG3719 Ribonuclease I 3 4 6 11 -------------------|-|--------------------|||-|--|---------||-||-- 14 [S] COG3755 Uncharacterized protein conserved in bacteria 3 5 7 11 --------------------------|----|-|||--------------|--|||---|--|--- 12 [S] COG3759 Predicted membrane protein 1 2 3 11 -------------------------------|||||||||||------------------------ 11 [S] COG3763 Uncharacterized protein conserved in bacteria 3 5 6 11 |--------|----------------|---||||||||---------------------------- 22 [M] COG3764 Sortase (surface protein transpeptidase) 1 2 3 11 ------------------------------------------|||||---||-------||||--- 11 [S] COG3768 Predicted membrane protein 1 2 3 11 ------------------------------------------|||||---||-------||||--- 11 [M] COG3770 Murein endopeptidase 3 5 6 11 ----------------|-------------|----|||----|||-|--|-----|---------- 20 [KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains 2 3 6 11 ------------------------------|-----||----|||||-|||--------------- 11 [KT] COG3835 Sugar diacid utilization regulator 2 4 5 11 ------------------|-----------------------|||||--|-----|---|||---- 11 [R] COG3895 Predicted periplasmic protein 5 7 9 11 --------------------||----|---||||---|----------|--|----------|--- 14 [R] COG3981 Predicted acetyltransferase 3 4 4 11 --------------------------|||-----|-------|||--------------||||--- 14 [S] COG4529 Uncharacterized protein conserved in bacteria 3 4 7 11 ---------------------|----|----------------|||--||-|-------||-|--- 11 [P] COG4558 ABC-type hemin transport system, periplasmic component 3 4 5 11 --------------------------||||-------|----|||-|----|----------|--- 11 [K] COG4578 Glucitol operon activator 5 8 9 11 ------------------||-|----|----------|-------|---|-----|---||-|--- 12 [R] COG4674 Uncharacterized ABC-type transport system, ATPase component 2 5 6 11 ------------------------------|||---------|||----------|---|-|||-- 21 [S] COG4695 Phage-related protein 2 4 7 11 --------------------------|||----------------|---|-|---|---||-||-- 15 [U] COG4965 Flp pilus assembly protein TadB 1 2 6 11 ------------------------------------------|||||-||--||||---------- 14 [NU] COG4967 Tfp pilus assembly protein PilV 2 3 6 11 ----------------|------------------------------------|||---||||||| 11 [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation 2 5 7 11 -------------||------------------------------|---------|---||||||| 16 [O] COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components 2 3 5 11 ---------------------|--------------------|||||-|-||-||----------- 14 [S] COG5339 Uncharacterized protein conserved in bacteria 5 7 7 11 ------------------||----|--||-------||-----------------|---||-|--- 20 [K] COG5662 Predicted transmembrane transcriptional regulator (anti-sigma factor)