y a o g gggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggg 3 6 7 10 -------------||---||----------------------|||-|--|---------|------ 15 [S] COG0401 Uncharacterized homolog of Blt101 5 6 7 10 --------|-------|----|-----||||||---|----------------------------- 11 [P] COG0490 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels 6 6 7 10 ---|------------|----|-----||--|----||---------------------|--|--- 10 [G] COG1023 Predicted 6-phosphogluconate dehydrogenase 3 8 9 10 -|||--|||||-|----|------------------------------------------------ 10 [C] COG1031 Uncharacterized Fe-S oxidoreductase 3 4 5 10 -----------------|---|--------||||||||---------------------------- 14 [J] COG1098 Predicted RNA binding protein (contains ribosomal protein S1 domain) 4 7 9 10 -|----|||||||---||------------------------------------------------ 16 [L] COG1110 Reverse gyrase 5 9 9 10 |-----|||---|---|---|----------------------------|--------|----|-- 11 [M] COG1213 Predicted sugar nucleotidyltransferases 4 7 9 10 ------||||||||||-------------------------------------------------- 13 [K] COG1224 DNA helicase TIP49, TBP-interacting protein 4 9 9 10 |||---||||-------|------------|---------------|------------------- 20 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II 4 6 7 10 ----------------||------------|-----||----------||------|||------- 10 [N] COG1334 Uncharacterized flagellar protein FlaG 3 7 9 10 -|----|||||||||--------------------------------------------------- 12 [R] COG1341 Predicted GTPase or GTP-binding protein 5 9 9 10 |||------|--------|||---------|-----------------------------|-|--- 18 [P] COG1348 Nitrogenase subunit NifH (ATPase) 1 8 8 10 ||||||||||-------------------------------------------------------- 11 [S] COG1422 Predicted membrane protein 6 8 8 10 -----------------||||--||-----|----|||---------------------------- 10 [R] COG1480 Predicted membrane-associated HD superfamily hydrolase 5 7 7 10 ------||----------||----|--||||------|---------------------------- 11 [S] COG1543 Uncharacterized conserved protein 4 9 9 10 |||---|||||-----||------------------------------------------------ 10 [S] COG1578 Uncharacterized conserved protein 3 7 9 10 -|----|||||||||--------------------------------------------------- 12 [S] COG1590 Uncharacterized conserved protein 2 7 9 10 ||-|--|||||||----------------------------------------------------- 11 [L] COG1591 Holliday junction resolvase - archaeal type 4 9 9 10 |||---||-|--------||-|--------|----------------------------------- 12 [C] COG1625 Fe-S oxidoreductase, related to NifB/MoaA family 5 10 10 10 |||-----||-------|||------|---|----------------------------------- 12 [S] COG1641 Uncharacterized conserved protein 2 7 9 10 -|||--|||||||----------------------------------------------------- 10 [R] COG1645 Uncharacterized Zn-finger containing protein 4 7 7 10 ------------------||-|--------------|-----||||---------|-----|---- 18 [S] COG1649 Uncharacterized protein conserved in bacteria 2 7 8 10 -||||||||--||----------------------------------------------------- 29 [N] COG1681 Archaeal flagellins 5 10 10 10 |||-----||-------|||------|---|----------------------------------- 10 [R] COG1691 NCAIR mutase (PurE)-related proteins 3 7 9 10 ||----||||||||---------------------------------------------------- 17 [R] COG1818 Predicted RNA-binding protein, contains THUMP domain 4 6 7 10 |--------|-------|--|---------|-||-|||---------------------------- 14 [R] COG1827 Predicted small molecule binding protein (contains 3H domain) 4 8 8 10 -||---|||---------||----------------|-----------------------|-|--- 12 [G] COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit 6 7 9 10 ------|||--------|--|---|-------|-------------|-|--|-------------- 14 [C] COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit 3 8 9 10 -|||--|||||-|-----------------------------------|----------------- 10 [S] COG1901 Uncharacterized conserved protein 4 9 9 10 -|||||--|-|-------------------|-----|------------------|---------- 12 [P] COG1910 Periplasmic molybdate-binding protein/domain 3 7 9 10 -|-|--|||||||---|------------------------------------------------- 12 [R] COG1913 Predicted Zn-dependent proteases 1 8 8 10 ||||||||||-------------------------------------------------------- 12 [L] COG1933 Archaeal DNA polymerase II, large subunit 4 5 5 10 -----------------|--|---------|---||||----|||--------------------- 12 [K] COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) 2 7 8 10 -||||||||--||----------------------------------------------------- 11 [NU] COG1955 Archaeal flagella assembly protein J 5 6 7 10 -----------------|||-|--||-----|---|||---------------------------- 10 [S] COG1963 Uncharacterized protein conserved in bacteria 5 8 8 10 ||------||------|----|-----||------------------------||----------- 19 [R] COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid 1 8 8 10 ||||||||||-------------------------------------------------------- 10 [R] COG2047 Uncharacterized protein (ATP-grasp superfamily) 5 10 10 10 |||-----||-|----|-||--------------------------------------|------- 17 [C] COG2048 Heterodisulfide reductase, subunit B 2 7 9 10 ||-|--|||||||----------------------------------------------------- 10 [S] COG2090 Uncharacterized protein conserved in archaea 3 4 6 10 ----------------|---|-----------------------------------|||--||||| 11 [S] COG2121 Uncharacterized protein conserved in bacteria 2 3 3 10 ---------------------------|||------------|||||---------||-------- 10 [I] COG2134 CDP-diacylglycerol pyrophosphatase 4 5 5 10 ----------------|-||------|||-------------|||-|------------------- 10 [S] COG2149 Predicted membrane protein 3 5 5 10 -----------------|------------|-----||----|||||-------------|----- 11 [G] COG2160 L-arabinose isomerase 3 5 6 10 ------------------||-------||-------------|||-|---------------||-- 10 [M] COG2173 D-alanyl-D-alanine dipeptidase 3 7 9 10 -||---|||||||-|--------------------------------------------------- 10 [J] COG2178 Predicted RNA-binding protein of the translin family 4 8 8 10 -|----||-|--------|--|---------------------------|-----|----|-|--- 14 [O] COG2192 Predicted carbamoyl transferase, NodU family 4 7 7 10 -----------------|------|-----|-----||-----------|------|||----|-- 11 [S] COG2257 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB 5 6 7 10 --||-----------------|-----|||------||----------||---------------- 10 [S] COG2320 Uncharacterized conserved protein 4 6 7 10 -------------------|-|---------------|----|||--------|||---|------ 14 [T] COG2336 Growth regulator 3 4 5 10 -----------------|---|--------||||||||---------------------------- 11 [R] COG2344 AT-rich DNA-binding protein 3 3 5 10 ---------------------|--------------|-----||||||||---------------- 10 [L] COG2356 Endonuclease I 5 5 8 10 --------|-||---------|--------------||-------||--|-|-------------- 15 [Q] COG2368 Aromatic ring hydroxylase 2 7 8 10 --||||||||-||----------------------------------------------------- 10 [S] COG2412 Uncharacterized conserved protein 2 7 9 10 |-||--|||||||----------------------------------------------------- 11 [S] COG2433 Uncharacterized conserved protein 4 8 8 10 |||----||-|-----|-----------------|-||---------------------------- 24 [S] COG2445 Uncharacterized conserved protein 1 8 8 10 ||||||||||-------------------------------------------------------- 10 [S] COG2450 Uncharacterized conserved protein 3 7 8 10 ------------------||--------------|-|------------|-----|--||--|--| 12 [V] COG2602 Beta-lactamase class D 5 9 9 10 |||------|--------|||---------|-----------------------------|-|--- 44 [C] COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains 3 4 5 10 --------------------------|||-|-----------|||-|-----|---------|--- 11 [S] COG2733 Predicted membrane protein 2 8 8 10 |||||||||------------|-------------------------------------------- 10 [C] COG2811 Archaeal/vacuolar-type H+-ATPase subunit H 2 4 6 10 --------------------------||||------------------||--|||---|------- 10 [C] COG2838 Monomeric isocitrate dehydrogenase 4 6 7 10 --------------------|-||------------|--------||--|---||---|------- 38 [S] COG2849 Uncharacterized protein conserved in bacteria 3 5 7 10 --------------------------|-----|-|-||-----------|--|||---|------- 12 [C] COG2851 H+/citrate symporter 2 7 8 10 -||||||||--||----------------------------------------------------- 11 [NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella 1 3 5 10 ------------------------------------------|||||--|---|||--|------- 12 [S] COG2879 Uncharacterized small protein 3 3 5 10 ---------------------------||-|-----------|||||-||---------------- 13 [K] COG2909 ATP-dependent transcriptional regulator 1 2 4 10 ------------------------------------------|||||||---|||----------- 10 [S] COG2922 Uncharacterized protein conserved in bacteria 2 2 4 10 --------------------|---------------------|||||||-||-------------- 10 [S] COG2926 Uncharacterized protein conserved in bacteria 2 5 8 10 ------------------||--------------------------|-|---|||-----||-|-- 13 [S] COG2929 Uncharacterized protein conserved in bacteria 4 5 7 10 ------------------|--------||--|--||----------------|-------|-||-- 16 [R] COG2936 Predicted acyl esterases 3 3 5 10 -------------------|-|--------------------|||||-|-||-------------- 14 [S] COG2949 Uncharacterized membrane protein 3 5 7 10 ---------------------|---------|-|-----------|---|--|---|||----|-- 10 [E] COG2957 Peptidylarginine deiminase and related enzymes 2 2 5 10 ----------------------|-------------------|||||-|-|||------------- 10 [K] COG2973 Trp operon repressor 1 2 5 10 ------------------------------------------|||||-||---|||---------- 10 [S] COG3009 Uncharacterized protein conserved in bacteria 1 2 5 10 ------------------------------------------|||||-||||---|---------- 10 [T] COG3026 Negative regulator of sigma E activity 2 2 4 10 ---------------------------||-------------|||||-|-||-------------- 10 [C] COG3029 Fumarate reductase subunit C 4 5 7 10 --|---------------|------------|--|-|---------|-|----------|-||--- 11 [M] COG3049 Penicillin V acylase and related amidases 2 3 5 10 --------------------|---------------------|||||-|-||---------|---- 13 [S] COG3055 Uncharacterized protein conserved in bacteria 2 3 5 10 ----------------|-------------------------|||||--|||--------|----- 10 [O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation 1 1 5 10 ------------------------------------------|||||-|||||------------- 10 [S] COG3079 Uncharacterized protein conserved in bacteria 2 2 4 10 ---------------------------||-------------|||||-|-||-------------- 10 [C] COG3080 Fumarate reductase subunit D 1 2 4 10 ------------------------------------------|||||-|-||-||----------- 10 [S] COG3094 Uncharacterized protein conserved in bacteria 1 1 5 10 ------------------------------------------|||||-|||||------------- 10 [R] COG3107 Putative lipoprotein 1 1 5 10 ------------------------------------------|||||-|||||------------- 10 [D] COG3115 Cell division protein 1 2 4 10 ------------------------------------------|||||-||---------|-||--- 11 [S] COG3126 Uncharacterized protein conserved in bacteria 2 5 7 10 ------------------||-----------------------------|--|--|---|||||-- 10 [S] COG3146 Uncharacterized protein conserved in bacteria 1 3 5 10 ------------------------------------------|||||-||-----|---|--|--- 28 [S] COG3157 Hemolysin-coregulated protein (uncharacterized) 4 4 6 10 ---------------------|----|---------|-----|||||--|--|------------- 10 [S] COG3162 Predicted membrane protein 1 2 4 10 ------------------------------------------|||||--|||-||----------- 11 [S] COG3171 Uncharacterized protein conserved in bacteria 4 9 9 10 |-||-----|--|---|--------------------------------|-----|----|-|--- 14 [S] COG3174 Predicted membrane protein 1 3 6 10 -------------------------------------------------|--||||---|||||-- 10 [R] COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases 3 5 8 10 --------------------------|-------|--|----------||---|||---|---|-- 19 [S] COG3182 Uncharacterized iron-regulated membrane protein 3 6 8 10 ------------------||------|---------------------||-----|---||-||-- 15 [ER] COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins 2 2 5 10 -------------------------------|---||-----|||||--||--------------- 10 [S] COG3223 Predicted membrane protein 4 7 8 10 ------------------||-------||-------|------------|-----|----|-||-- 27 [I] COG3239 Fatty acid desaturase 3 5 7 10 ----------||------|------------------------------|---|||---|||---- 10 [P] COG3256 Nitric oxide reductase large subunit 2 3 4 10 ---------------------|--------------------|||-|--|---------||||--- 10 [R] COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization 3 4 6 10 --------------------|----------------|----|||-|-||---------|--|--- 10 [P] COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain 3 4 5 10 ------|||-----------------------||--------|||-|-|----------------- 10 [S] COG3270 Uncharacterized conserved protein 3 4 5 10 --------------------|-------------|-|-----|||||-|-----------|----- 13 [T] COG3275 Putative regulator of cell autolysis 5 7 8 10 -----------|-------|-|----|||-----------------|--|-----|----|----- 10 [G] COG3280 Maltooligosyl trehalose synthase 4 5 5 10 --------------------|-----||-||---||||-----------|---------------- 11 [S] COG3323 Uncharacterized protein conserved in bacteria 4 6 9 10 --------------------|-----|----------|--------|-||-|---|---||----- 16 [S] COG3333 Uncharacterized protein conserved in bacteria 1 2 3 10 -------------------------------||||||||-||------------------------ 10 [K] COG3343 DNA-directed RNA polymerase, delta subunit 3 7 8 10 --|||||||-||-------|---------------------------------------------- 11 [S] COG3372 Uncharacterized conserved protein 4 5 5 10 |---||-----|----------------------|||----------------------||-|--- 12 [R] COG3383 Uncharacterized anaerobic dehydrogenase 2 3 4 10 -----------------------------------|-|----|||||-|------------||--- 12 [S] COG3394 Uncharacterized protein conserved in bacteria 1 2 3 10 ------------------------------------------|||||||-------|||------- 10 [R] COG3417 Collagen-binding surface adhesin SpaP (antigen I/II family) 2 3 4 10 -------------------|----------------------||||---|---------||||--- 14 [P] COG3454 Metal-dependent hydrolase involved in phosphonate metabolism 5 8 9 10 --|-----|-----|---||----------||----|----------------------||----- 13 [T] COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) 2 2 3 10 --------------------------||||-|||-|||---------------------------- 11 [T] COG3480 Predicted secreted protein containing a PDZ domain 2 4 6 10 -------------------|-----------------------||||--|--|--|---|--|--- 12 [R] COG3497 Phage tail sheath protein FI 2 4 6 10 -------------------|----------------------|||-|--|--|--|---|--|--- 12 [R] COG3500 Phage protein D 2 4 6 10 -------------------|-----------------------||||-||-----|---|--|--- 45 [S] COG3501 Uncharacterized protein conserved in bacteria 2 6 7 10 |-|-----|----------------------------------------|-----|---|||||-- 10 [S] COG3503 Predicted membrane protein 2 4 5 10 --------------------------||||-------------------|-----|---||-||-- 12 [Q] COG3509 Poly(3-hydroxybutyrate) depolymerase 3 6 7 10 -------------|----------------||--||-------------|---||----|-|---- 11 [R] COG3560 Predicted oxidoreductase related to nitroreductase 4 5 5 10 --|-----------------------||||-|||------------------|----------|-- 10 [O] COG3590 Predicted metalloendopeptidase 2 3 4 10 ---------------------------------||-|-----|||||-------------|-|--- 18 [E] COG3591 V8-like Glu-specific endopeptidase 3 4 5 10 ------||---------|------------|||||||----------------------------- 10 [S] COG3601 Predicted membrane protein 1 2 3 10 -------------------------------||||||||-||------------------------ 10 [L] COG3611 Replication initiation/membrane attachment protein 5 8 9 10 --|-----------|----------|-----|------|----------|-----|---|--||-- 11 [F] COG3613 Nucleoside 2-deoxyribosyltransferase 2 3 4 10 ---------------------------------|--------|||||---||-||----------- 11 [P] COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance 2 3 7 10 -------------------------------||--|-------|||---||-|--------|---- 21 [K] COG3617 Prophage antirepressor 5 7 8 10 --||-----------------|-----||-------|------------|---------|--||-- 18 [R] COG3631 Ketosteroid isomerase-related protein 3 6 9 10 -------------------|-------------|-----|-----||-||---|-------|-|-- 10 [R] COG3654 Prophage maintenance system killer protein 4 6 7 10 -------------------|------|---|-||-|||-----------|-------------|-- 15 [K] COG3655 Predicted transcriptional regulator 3 4 5 10 --------------------|---|--------------------||---||-------||||--- 10 [R] COG3683 ABC-type uncharacterized transport system, periplasmic component 2 3 4 10 ------------------------------------||----|||||------------||--|-- 11 [G] COG3717 5-keto 4-deoxyuronate isomerase 2 3 5 10 -------------------------------||-|||------|||---|------------|--- 16 [L] COG3728 Phage terminase, small subunit 3 5 7 10 ---------------------------||--|---|-------||-|--------|---|---|-- 14 [R] COG3740 Phage head maturation protease 2 3 4 10 ------------------------------|-||||-|----|||-|------------------- 17 [G] COG3775 Phosphotransferase system, galactitol-specific IIC component 1 2 3 10 ------------------------------------------|||||------------|||||-- 10 [S] COG3785 Uncharacterized conserved protein 3 4 5 10 ---------------------------||||----|-----------------------|||||-- 10 [S] COG3786 Uncharacterized protein conserved in bacteria 3 6 7 10 --------------------------|---||--||-------------|-----|---||-|--- 13 [S] COG3865 Uncharacterized protein conserved in bacteria 2 3 5 10 ------------------------|-----------------||||||||-----|---------- 11 [MNO] COG3951 Rod binding protein 5 7 8 10 --|----------||------------|||||--|-----------|------------------- 17 [GHR] COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes 4 4 5 10 --------|-----------|----|----------------|||||---||-------------- 10 [H] COG4145 Na+/panthothenate symporter 2 3 4 10 ---------------------------------|--------|||-|---|--------||||--- 12 [G] COG4154 Fucose dissimilation pathway protein FucU 1 3 6 10 ------------------------------------------|||||-||-----|-----|-|-- 11 [H] COG4206 Outer membrane cobalamin receptor protein 3 3 5 10 --------------------|---|-----------------|||||-|-||-------------- 10 [G] COG4211 ABC-type glucose/galactose transport system, permease component 1 3 6 10 ------------------------------------------------||-----|---||||||| 14 [S] COG4395 Uncharacterized protein conserved in bacteria 2 4 7 10 ---------------------------||--------------||-|-|-|-|--|----|----- 17 [S] COG4453 Uncharacterized protein conserved in bacteria 3 3 4 10 ---------------------|-------------|||----|||||-|----------------- 18 [R] COG4533 ABC-type uncharacterized transport system, periplasmic component 3 4 6 10 ---------------------|----|----------------|||--||---------||-|--- 10 [P] COG4559 ABC-type hemin transport system, ATPase component 1 2 4 10 ------------------------------------------|||||-||---------||-|--- 13 [E] COG4598 ABC-type histidine transport system, ATPase component 3 4 6 10 --|----------------------------|----------|||||-|--|----------|--- 10 [CH] COG4635 Flavodoxin 5 7 9 10 ---|----|---|--------|---------------|----------||-|--------||---- 18 [R] COG4666 TRAP-type uncharacterized transport system, fused permease components 4 4 6 10 --------------------|-----|---|-----------|||||-|--|-------------- 10 [R] COG4667 Predicted esterase of the alpha-beta hydrolase superfamily 2 4 5 10 ------------------------||-----------------------------|||-|||||-- 14 [S] COG4731 Uncharacterized protein conserved in bacteria 2 2 3 10 -------------------------------|||||||------------------|||------- 10 [U] COG4940 Competence protein ComGF 3 3 4 10 --------------------------||||-----|||---------------|||---------- 10 [S] COG5416 Uncharacterized integral membrane protein 1 3 4 10 ------------------------------------------|||-|--------|---|||||-- 10 [S] COG5455 Predicted integral membrane protein 3 4 5 10 -----------------|------------|-----||----|||||--|---------------- 10 [M] COG5581 Predicted glycosyltransferase