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14 28 38 66 |||||||||||||||||||||||||||||||||||||| 70 [U] COG0201 Preprotein translocase subunit SecY
11 22 29 50 ||||-|-|------|||||||||||-|||||||||||| 52 [U] COG0341 Preprotein translocase subunit SecF
11 22 29 50 ||||-|-|------|||||||||||-|||||||||||| 55 [U] COG0342 Preprotein translocase subunit SecD
14 28 38 66 |||||||||||||||||||||||||||||||||||||| 66 [U] COG0541 Signal recognition particle GTPase
14 28 38 66 |||||||||||||||||||||||||||||||||||||| 66 [U] COG0552 Signal recognition particle GTPase
10 16 24 50 --------------|||||||||||||||||||||||| 50 [MU] COG0597 Lipoprotein signal peptidase
12 22 30 51 |||||||-|-|---|||||||||-|--||||||||||| 89 [OU] COG0616 Periplasmic serine proteases (ClpP class)
3 10 14 21 -||||||-|||------------------|----|||| 52 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis
10 16 24 50 --------------|||||||||||||||||||||||| 61 [U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase)
14 28 38 63 |||||||||||||||||||||||||||||||||||||| 93 [U] COG0681 Signal peptidase I
10 16 24 50 --------------|||||||||||||||||||||||| 50 [U] COG0690 Preprotein translocase subunit SecE
11 18 26 52 -----------||-|||||||||||||||||||||||| 62 [U] COG0706 Preprotein translocase subunit YidC
10 15 23 46 --------------||||||||||||-||||||||||| 84 [OU] COG0740 Protease subunit of ATP-dependent Clp proteases
9 15 23 42 --------------||||||-||||||||||||||||| 46 [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake
8 15 24 43 --|||-|-|||---|-|||---|-|--||||||||||| 49 [U] COG0805 Sec-independent protein secretion pathway component TatC
7 13 20 33 |-|----|------|-|||||------||||||||||| 71 [U] COG0811 Biopolymer transport proteins
4 9 15 27 --|---|---------||--|------||||||-|||| 38 [U] COG0823 Periplasmic component of the Tol biopolymer transport system
6 10 17 30 --------------|-|||||------||||||||||| 65 [U] COG0848 Biopolymer transport protein
6 10 13 27 --------------||----||-||--||-|-|-|||- 41 [NU] COG1157 Flagellar biosynthesis/type III secretory pathway ATPase
6 10 13 27 --------------||----||-||--||-|-|-|||- 31 [NU] COG1298 Flagellar biosynthesis pathway, component FlhA
9 15 23 47 --------------|-|||||||||||||||||||||| 47 [U] COG1314 Preprotein translocase subunit SecG
5 9 11 21 ---------------|----||-||--||-|-|-|-|- 25 [NU] COG1317 Flagellar biosynthesis/type III secretory pathway protein
6 10 13 27 --------------||----||-||--||-|-|-|||- 29 [NU] COG1338 Flagellar biosynthesis pathway, component FliP
6 10 13 27 --------------||----||-||--||-|-|-|||- 32 [NU] COG1377 Flagellar biosynthesis pathway, component FlhB
4 12 14 16 ||||||||||||||------------------------ 16 [U] COG1400 Signal recognition particle 19 kDa protein
4 7 11 16 --------------|----||------||||-|-|||- 30 [NU] COG1450 Type II secretory pathway, component PulD
8 12 19 31 --------------|||||||--|||-|||||||-||- 45 [NU] COG1459 Type II secretory pathway, component PulF
5 8 10 19 --------------||-----|-||--||-|-|-|--- 21 [NUO] COG1516 Flagellin-specific chaperone FliS
4 8 15 27 --------------|-||-|-------||||||||||| 113 [MU] COG1538 Outer membrane protein
9 15 22 33 ||-|-|-||||----|||||--||---|||||---||- 35 [OU] COG1585 Membrane protein implicated in regulation of membrane protease activity
5 9 12 25 --------------||-----|-||--||-|-|-|||- 26 [NU] COG1677 Flagellar hook-basal body protein
5 9 12 25 --------------||-----|-||--||-|-|-|||- 26 [NU] COG1684 Flagellar biosynthesis pathway, component FliR
3 5 8 15 ---------------|--------||-||-|-|---|- 27 [NU] COG1705 Muramidase (flagellum-specific)
5 9 12 25 --------------||-----|-||--||-|-|-|||- 27 [NU] COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein
8 16 25 44 --|||-|||||---|-|||---|-|--||||||||||| 86 [U] COG1826 Sec-independent protein secretion pathway components
8 12 20 42 --------------||---|||||||-||||||||||| 43 [U] COG1862 Preprotein translocase subunit YajC
6 10 13 27 --------------||----||-||--||-|-|-|||- 45 [NU] COG1886 Flagellar motor switch/type III secretory pathway protein
2 4 11 22 -|-------------------------|||||||-||| 22 [U] COG1952 Preprotein translocase subunit SecB
2 7 8 10 -||||||--||--------------------------- 11 [NU] COG1955 Archaeal flagella assembly protein J
5 9 12 25 --------------||-----|-||--||-|-|-|||- 26 [NU] COG1987 Flagellar biosynthesis pathway, component FliQ
8 19 26 40 ||||-|||------|||||---||||-||||||||||- 50 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
5 14 19 24 |||||||||||-----------||---||--||--||- 44 [NU] COG2064 Flp pilus assembly protein TadC
9 17 25 37 -||-|||||||---|-|-|-||--|--||||||||||- 64 [U] COG2095 Multiple antibiotic transporter
8 13 19 30 --------------|||||||--|||-||||||-|||- 88 [NU] COG2165 Type II secretory pathway, pseudopilin PulG
4 12 12 14 ||||||||--||||------------------------ 14 [U] COG2443 Preprotein translocase subunit Sss1
4 6 8 13 --------------||-------||--||-|-|----- 13 [KNU] COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor)
8 13 20 32 --------------|||||||--|||-||||||||||- 48 [NU] COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB
7 9 13 18 --------------||||||---|---||||-||---- 23 [NU] COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT
3 7 11 15 ----------------||-|-------|||-|||||-- 42 [U] COG2831 Hemolysin activation/secretion protein
2 7 8 10 -||||||--||--------------------------- 11 [NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella
4 6 8 14 ---------------|-----|-||--||-|-|----- 14 [NUO] COG2882 Flagellar biosynthesis chaperone
1 4 6 11 -----------------------------|--|-|||| 23 [U] COG2948 Type IV secretory pathway, VirB10 components
2 2 3 3 --------------|-------------|-|------- 4 [U] COG3031 Type II secretory pathway, component PulC
1 2 7 9 ---------------------------|||||||---- 9 [NU] COG3063 Tfp pilus assembly protein PilF
1 1 4 9 ---------------------------||-||------ 10 [U] COG3114 Heme exporter protein D
3 5 8 14 -----------------||--------|||--|---|| 86 [NU] COG3121 P pilus assembly protein, chaperone PapD
1 2 4 4 ---------------------------||-|-|----- 5 [U] COG3149 Type II secretory pathway, component PulM
1 3 7 8 ---------------------------||||-|--||- 9 [U] COG3156 Type II secretory pathway, component PulK
2 5 9 14 ----------------||---------||||-||--|- 15 [NU] COG3166 Tfp pilus assembly protein PilN
1 2 5 6 ---------------------------|-||-||---- 6 [NU] COG3167 Tfp pilus assembly protein PilO
1 2 5 6 ---------------------------|-||-||---- 6 [NU] COG3168 Tfp pilus assembly protein PilP
1 2 5 6 ---------------------------|-||-||---- 8 [NU] COG3170 Tfp pilus assembly protein FimV
2 4 7 12 -----------------|---------|||--|---|| 70 [NU] COG3188 P pilus assembly protein, porin PapC
3 7 11 15 ----------------||-|-------|||-|||||-- 79 [U] COG3210 Large exoproteins involved in heme utilization or adhesion
1 2 4 5 ---------------------------|-|--||---- 5 [NU] COG3215 Tfp pilus assembly protein PilZ
2 2 4 5 ----------------------|----||-|------- 9 [U] COG3267 Type II secretory pathway, component ExeA (predicted ATPase)
1 2 4 5 ---------------------------||-|----|-- 6 [U] COG3297 Type II secretory pathway, component PulL
1 1 3 8 ---------------------------||-|------- 8 [NUO] COG3418 Flagellar biosynthesis/type III secretory pathway chaperone
1 2 4 4 ---------------------------|-|--||---- 9 [NU] COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1
3 7 10 15 ---|-------------------|--|-||--|-|||| 27 [U] COG3451 Type IV secretory pathway, VirB4 components
1 3 4 13 ----------------------------|--|-|--|- 55 [MU] COG3468 Type V secretory pathway, adhesin AidA
1 4 6 11 -----------------------------|--|-|||| 25 [U] COG3504 Type IV secretory pathway, VirB9 components
3 6 8 12 ----------------|------|----||--|-|-|| 21 [U] COG3505 Type IV secretory pathway, VirD4 components
1 1 3 7 ---------------------------|||-------- 134 [NU] COG3539 P pilus assembly protein, pilin FimA
2 5 8 12 ----------------||---------||-|-||--|- 21 [UNTP] COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
1 3 4 5 -----------------------------|--|--||- 7 [U] COG3701 Type IV secretory pathway, TrbF components
1 2 4 7 -----------------------------|-----||| 9 [U] COG3702 Type IV secretory pathway, VirB3 components
1 2 4 8 -----------------------------|-----||| 17 [U] COG3704 Type IV secretory pathway, VirB6 components
1 3 4 9 -----------------------------|----|-|| 16 [U] COG3736 Type IV secretory pathway, component VirB8
1 3 4 6 ---------------------------|----|--||- 10 [U] COG3745 Flp pilus assembly protein CpaB
1 3 5 8 -----------------------------|--|--||| 13 [U] COG3838 Type IV secretory pathway, VirB2 components (pilins)
2 5 5 7 -------------------------|---|--|-|-|- 12 [U] COG3843 Type IV secretory pathway, VirD2 components (relaxase)
1 4 4 6 -----------------------------|--|-|-|- 10 [U] COG3846 Type IV secretory pathway, TrbL components
1 3 5 7 ---------------------------|---||--||- 16 [U] COG3847 Flp pilus assembly protein, pilin Flp
1 3 4 6 ---------------------------|-|--|---|- 8 [U] COG3946 Type IV secretory pathway, VirJ component
2 4 5 6 ---||--||-|--------------------------- 6 [U] COG4023 Preprotein translocase subunit Sec61beta
1 1 2 7 ------------------------||------------ 8 [U] COG4473 Predicted ABC-type exoprotein transport system, permease component
1 1 2 7 ------------------------||------------ 7 [U] COG4537 Competence protein ComGC
2 4 5 9 --------------------|------||---|---|- 13 [U] COG4669 Type III secretory pathway, lipoprotein EscJ
1 2 4 5 ---------------------------|-|--||---- 8 [NU] COG4726 Tfp pilus assembly protein PilX
2 4 5 9 --------------------|------||---|---|- 13 [U] COG4789 Type III secretory pathway, component EscV
1 3 4 7 ---------------------------||---|---|- 11 [U] COG4790 Type III secretory pathway, component EscR
2 4 5 9 --------------------|------||---|---|- 15 [U] COG4791 Type III secretory pathway, component EscT
1 2 3 6 ---------------------------||-------|- 7 [U] COG4792 Type III secretory pathway, component EscU
2 4 5 9 --------------------|------||---|---|- 13 [U] COG4794 Type III secretory pathway, component EscS
1 3 7 12 ---------------------------||||||--|-- 16 [U] COG4795 Type II secretory pathway, component PulJ
4 6 11 17 --------------||||---------|||||||---- 21 [U] COG4796 Type II secretory pathway, component HofQ
2 2 3 10 ------------------------||--------|--- 10 [U] COG4940 Competence protein ComGF
1 3 3 4 -----------------------------|--|---|- 5 [OU] COG4959 Type IV secretory pathway, protease TraF
1 3 6 8 ---------------------------||--||--||- 10 [OU] COG4960 Flp pilus assembly protein, protease CpaA
1 3 6 8 ---------------------------||--||--||- 27 [U] COG4961 Flp pilus assembly protein TadG
4 9 13 18 ||---|-|--------------||---|||-||--||- 27 [U] COG4962 Flp pilus assembly protein, ATPase CpaF
1 3 6 8 ---------------------------||--||--||- 12 [U] COG4963 Flp pilus assembly protein, ATPase CpaE
2 4 6 8 ------------------|--------|---||--||- 13 [U] COG4964 Flp pilus assembly protein, secretin CpaC
2 4 7 11 ----------------------|----||--||--||- 15 [U] COG4965 Flp pilus assembly protein TadB
1 2 4 5 ---------------------------|-|--||---- 9 [NU] COG4966 Tfp pilus assembly protein PilW
1 2 6 11 ---------------------------||||-||---- 14 [NU] COG4967 Tfp pilus assembly protein PilV
1 2 5 6 ---------------------------|-||-||---- 12 [NU] COG4968 Tfp pilus assembly protein PilE
2 3 8 14 --------------|------------|||||||---- 41 [NU] COG4969 Tfp pilus assembly protein, major pilin PilA
1 3 6 7 ---------------------------|-||-||--|- 14 [NU] COG4970 Tfp pilus assembly protein FimT
3 5 8 9 ----------------|||--------|-||-||---- 9 [NU] COG4972 Tfp pilus assembly protein, ATPase PilM
1 2 5 6 ---------------------------|-||-||---- 8 [NU] COG5008 Tfp pilus assembly protein, ATPase PilU
1 3 6 8 ---------------------------||--||--||- 11 [U] COG5010 Flp pilus assembly protein TadD, contains TPR repeats
2 3 3 3 -----------|||------------------------ 7 [U] COG5028 Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3
2 3 3 3 -----------|||------------------------ 7 [U] COG5030 Clathrin adaptor complex, small subunit
2 3 3 3 -----------|||------------------------ 22 [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family
2 3 3 3 -----------|||------------------------ 5 [U] COG5043 Vacuolar protein sorting-associated protein
2 3 3 3 -----------|||------------------------ 5 [U] COG5047 Vesicle coat complex COPII, subunit SEC23
2 3 3 3 -----------|||------------------------ 5 [U] COG5052 Protein involved in membrane traffic
2 3 3 3 -----------|||------------------------ 5 [U] COG5058 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor
2 3 3 3 -----------|||------------------------ 4 [OU] COG5061 Oxidoreductin, endoplasmic reticulum membrane-associated protein involved in disulfide bond formation
2 3 3 3 -----------|||------------------------ 4 [U] COG5064 Karyopherin (importin) alpha
2 3 3 3 -----------|||------------------------ 4 [U] COG5066 VAMP-associated protein involved in inositol metabolism
2 3 3 3 -----------|||------------------------ 5 [GOU] COG5070 Nucleotide-sugar transporter
2 3 3 3 -----------|||------------------------ 5 [U] COG5073 Vacuolar import and degradation protein
2 3 3 3 -----------|||------------------------ 4 [U] COG5074 t-SNARE complex subunit, syntaxin
2 3 3 3 -----------|||------------------------ 4 [UD] COG5079 Nuclear protein export factor
2 3 3 3 -----------|||------------------------ 5 [U] COG5080 Rab GTPase interacting factor, Golgi membrane protein
2 3 3 3 -----------|||------------------------ 9 [OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger
2 3 3 3 -----------|||------------------------ 10 [U] COG5096 Vesicle coat complex, various subunits
2 3 3 3 -----------|||------------------------ 3 [U] COG5100 Nuclear pore protein
2 3 3 3 -----------|||------------------------ 6 [U] COG5101 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily)
2 3 3 3 -----------|||------------------------ 3 [U] COG5102 Membrane protein involved in ER to Golgi transport
2 3 3 3 -----------|||------------------------ 3 [JU] COG5117 Protein involved in the nuclear export of pre-ribosomes
2 3 3 3 -----------|||------------------------ 3 [U] COG5120 Membrane protein involved in Golgi transport
2 3 3 3 -----------|||------------------------ 3 [U] COG5122 Transport protein particle (TRAPP) complex subunit
2 3 3 3 -----------|||------------------------ 3 [U] COG5128 Transport protein particle (TRAPP) complex subunit
2 3 3 3 -----------|||------------------------ 3 [UT] COG5130 Prenylated rab acceptor 1 and related proteins
2 3 3 3 -----------|||------------------------ 10 [U] COG5143 Synaptobrevin/VAMP-like protein
2 3 3 3 -----------|||------------------------ 3 [UI] COG5153 Putative lipase essential for disintegration of autophagic bodies inside the vacuole
2 3 3 3 -----------|||------------------------ 11 [U] COG5158 Proteins involved in synaptic transmission and general secretion, Sec1 family
2 3 3 3 -----------|||------------------------ 3 [U] COG5167 Protein involved in vacuole import and degradation
2 3 3 3 -----------|||------------------------ 3 [U] COG5171 Ran GTPase-activating protein (Ran-binding protein)
2 3 3 3 -----------|||------------------------ 3 [U] COG5173 Exocyst complex subunit SEC6
2 3 3 3 -----------|||------------------------ 3 [U] COG5196 ER lumen protein retaining receptor
2 3 3 3 -----------|||------------------------ 3 [U] COG5215 Karyopherin (importin) beta
2 3 3 3 -----------|||------------------------ 3 [U] COG5232 Preprotein translocase subunit Sec62
2 3 3 3 -----------|||------------------------ 3 [U] COG5233 Peripheral Golgi membrane protein
2 3 3 3 -----------|||------------------------ 3 [U] COG5240 Vesicle coat complex COPI, gamma subunit
2 3 3 3 -----------|||------------------------ 3 [U] COG5249 Golgi protein involved in Golgi-to-ER retrieval
1 3 3 4 -----------------------------|--|---|- 4 [NU] COG5268 Type IV secretory pathway, TrbD component
4 6 9 16 --|----------------|----|---||-|||--|- 25 [UW] COG5295 Autotransporter adhesin
2 3 3 3 -----------|||------------------------ 4 [U] COG5308 Nuclear pore complex subunit
1 3 3 4 -----------------------------|--|---|- 6 [U] COG5314 Conjugal transfer/entry exclusion protein
2 3 3 3 -----------|||------------------------ 6 [U] COG5325 t-SNARE complex subunit, syntaxin
2 3 3 3 -----------|||------------------------ 14 [U] COG5347 GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport
2 3 3 3 -----------|||------------------------ 13 [UR] COG5391 Phox homology (PX) domain protein
2 3 3 3 -----------|||------------------------ 3 [U] COG5407 Preprotein translocase subunit Sec63
2 3 3 3 -----------|||------------------------ 3 [U] COG5538 Preprotein translocase subunit Sec66