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4 8 15 26 ---|-------||---||---------|||||||-||| 37 [T] COG0271 Stress-induced morphogen (activity unknown)
9 15 23 44 --------------||||||-||||||||||||||||| 67 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases
8 17 24 38 |-||--|----||-|-|||---||||-||||||||||- 70 [T] COG0394 Protein-tyrosine-phosphatase
7 15 17 21 ||||||||||||--||||------------------|- 70 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction
4 10 12 13 -|||-|||||||||------------------------ 14 [T] COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
11 19 25 41 ---||---||-||||-|||-|-|||||||||||-|-|- 407 [RTKL] COG0515 Serine/threonine protein kinase
9 19 28 48 |||||||||||-|-|-|||---|-||-||-||||-||| 207 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins
9 16 18 31 ----|------||-|-|||-|-||||||-|--|-|-|- 55 [T] COG0631 Serine/threonine protein phosphatase
10 22 31 45 -|||||||||||||-|||||---|||-||||||||||- 112 [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
12 21 29 50 |-||--|----||-||||||||||||-||||||||||| 798 [T] COG0642 Signal transduction histidine kinase
7 15 19 31 --||-||--------||||--|-||--||||-|-|||- 46 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases
12 18 25 42 -----------|||||||||||||||-||||||||||- 178 [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
9 14 22 43 --------------|||||||-||||-||||||||||| 429 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
10 20 25 40 |-||-||----|||-||||--||||--||||||-|||- 545 [T] COG0784 FOG: CheY-like receiver
11 17 25 46 --|---|-|-|----|||||||||||-||-|||||||| 270 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
6 14 18 30 --||-||--------|||---|-||--||||-|-|||- 76 [NT] COG0835 Chemotaxis signal transduction protein
7 15 19 31 --||-||--------||||--|-||--||||-|-|||- 323 [NT] COG0840 Methyl-accepting chemotaxis protein
6 11 19 40 ----------------||||--||||-||||||||||| 40 [T] COG1217 Predicted membrane GTPase involved in stress response
4 7 9 14 ---------------|||-----||--||-|-|----- 28 [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
6 13 16 26 --||-||--------||----|-||--||-|-|-|||- 44 [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins
9 12 14 20 ---------------||||||||||--|--|----||- 69 [T] COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
3 5 10 22 --------------|-------|----||-||||-||- 22 [OT] COG1391 Glutamine synthetase adenylyltransferase
5 9 12 24 -------|-----------|-|-||||--|--||-||- 24 [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism
4 6 10 20 ---------------|-----|-||--|||||--|--- 20 [T] COG1551 Carbon storage regulator (could also regulate swarming and quorum sensing)
3 4 5 5 ---------------|-----|-----|--|---|--- 10 [T] COG1639 Predicted signal transduction protein
9 12 20 36 -------||-|---|||||---|-||-|||||||-||- 42 [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase
8 11 12 16 --------||-||---|||-|-|||----|-------- 58 [T] COG1716 FOG: FHA domain
6 14 17 19 ||||||||||||||----|--------||--------- 20 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control
5 9 16 30 --------------|-----||-||--||||||||||| 52 [T] COG1734 DnaK suppressor protein
6 10 16 34 -------------------||||||||||-||||-||- 127 [GT] COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)
5 10 10 15 --||-||--------|-----|-||-----|---|--- 25 [NT] COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
7 10 13 21 --|-----------|-|||---|||--||-|----||- 30 [KT] COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
4 7 10 23 ------------------|--|-|||--|-||-||--- 23 [T] COG1854 LuxS protein involved in autoinducer AI2 synthesis
5 11 13 16 --||-||--------|-----|-||--|--|-|--||- 17 [NT] COG1871 Chemotaxis protein; stimulates methylation of MCP proteins
5 6 8 13 ---------------|----|-|-|--|-||-|----- 14 [T] COG1875 Predicted ATPase related to phosphate starvation-inducible protein PhoH
5 9 15 26 ---||------|---|-------|||-|||||-|-||- 26 [T] COG1956 GAF domain-containing protein
7 11 17 28 --|--|--|-|---|----|--||||-||-|||||--- 34 [T] COG1966 Carbon starvation protein, predicted membrane protein
6 10 16 30 ---------------||||---||||-||||||--||- 50 [KT] COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases)
5 7 9 18 --|--|---------|------||||--|-|------- 24 [KT] COG1983 Putative stress-responsive transcriptional regulator
6 10 17 28 ------|-|||---|-||----|----||||||-|||- 31 [T] COG2062 Phosphohistidine phosphatase SixA
3 5 7 8 -|---||-|||---|----------------------- 8 [T] COG2112 Predicted Ser/Thr protein kinase
7 10 11 16 --|--------|||--||---||----|-------||- 102 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)
6 8 8 13 ---------------||||-|-|||------------- 28 [T] COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase)
5 9 16 32 ----------------|||---||||-|||||||-||- 199 [TK] COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
3 6 9 14 -----------||---||---------||-||----|- 52 [T] COG2198 FOG: HPt domain
8 12 16 29 --------------|||||--||||--||||-|--||- 359 [T] COG2199 FOG: GGDEF domain
7 11 16 29 --------------|-|||--||||--||||-|--||| 227 [T] COG2200 FOG: EAL domain
6 13 17 26 --||-||--------||----|-||--||||-|-|||- 39 [NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain
11 19 23 36 |-||--|-----|-|||||-|||||--||||-|-|||- 446 [T] COG2202 FOG: PAS/PAC domain
9 16 19 28 |-||--|-----|-|||||---|||--||-|-|--||- 172 [T] COG2203 FOG: GAF domain
6 9 16 29 --------------|----|||--|--||||||||||| 89 [T] COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
5 10 13 21 ----------------|||---|||--||-|-|-|||- 23 [T] COG2205 Osmosensitive K+ channel histidine kinase
7 10 11 13 --------------|||-|--|-||--|--|-|---|- 35 [T] COG2206 HD-GYP domain
8 11 12 18 ---------------|||-||||||--|--|-----|- 33 [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit
4 5 5 7 -----------------||----||---|--------- 33 [T] COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1
4 6 7 10 ----------------|-|-----|---|---||--|- 14 [T] COG2336 Growth regulator
5 8 10 19 ----------------|-|---|||---||---|--|| 41 [T] COG2337 Growth inhibitor
5 8 11 12 -----------||-----|---|-||-||---|--||- 19 [T] COG2365 Protein tyrosine/serine phosphatase
7 10 13 17 -||--|--||-||---|-|---|----||-|------- 27 [T] COG2453 Predicted protein-tyrosine phosphatase
4 6 7 14 ------------------|---||||-|--------|- 36 [TQ] COG2508 Regulator of polyketide synthase expression
3 5 7 13 ---|-------------------||--||-|-----|- 14 [T] COG2766 Putative Ser protein kinase
6 10 11 13 --|---|-------|-|||-----|--|--|-|---|- 23 [T] COG2770 FOG: HAMP domain
5 5 6 6 ------|-------|-------|-|--|--|------- 8 [T] COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains
3 5 8 12 -------------------|---|||-|-||-|----- 33 [T] COG2972 Predicted signal transduction protein with a C-terminal ATPase domain
1 2 5 10 ---------------------------||-|||----- 10 [T] COG3026 Negative regulator of sigma E activity
1 2 6 11 ---------------------------||||||----- 11 [T] COG3073 Negative regulator of sigma E activity
3 3 6 11 ---------------|---|-------||-||------ 12 [T] COG3086 Positive regulator of sigma E activity
2 2 5 11 ------------------------|--||-||------ 15 [T] COG3103 SH3 domain protein
1 1 4 9 ---------------------------||-||------ 10 [T] COG3109 Activator of osmoprotectant transporter ProP
1 2 4 8 ---------------------------||-|-|----- 9 [NT] COG3143 Chemotaxis protein
3 4 5 10 -------------------|----|---|-|-----|- 13 [T] COG3275 Putative regulator of cell autolysis
3 6 11 23 -------------------|---|||-||||-|--||- 42 [KT] COG3279 Response regulator of the LytR/AlgR family
3 3 5 9 ----------------------|-||--|-|------- 20 [T] COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism
2 3 4 4 ----------------||-----------||------- 5 [T] COG3292 Predicted periplasmic ligand-binding sensor domain
3 5 7 9 -----------------|------|--||---|--||- 12 [T] COG3300 MHYT domain (predicted integral membrane sensor domain)
2 4 7 7 --|---|--------------------||-|----||- 12 [T] COG3322 Predicted periplasmic ligand-binding sensor domain
3 3 3 3 --------------|---------|-----|------- 6 [T] COG3434 Predicted signal transduction protein containing EAL and modified HD-GYP domains
6 7 9 9 ---------------||||--|-|---|-||------- 16 [KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain
2 4 5 9 ----------------||---------||-------|- 12 [T] COG3447 Predicted integral membrane sensor domain
2 4 4 6 -----------------|---------|----|---|- 6 [T] COG3448 CBS-domain-containing membrane protein
2 4 4 5 ----------------||------------|-----|- 5 [T] COG3452 Predicted periplasmic ligand-binding sensor domain
1 2 4 7 ---------------------------||-|-----|- 9 [T] COG3456 Uncharacterized conserved protein, contains FHA domain
5 8 9 10 --|---|-----|---||-----|||----------|- 13 [T] COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
2 2 3 10 ----------------------|-||------------ 11 [T] COG3480 Predicted secreted protein containing a PDZ domain
3 5 7 11 --------------|------|-----||-|-|---|- 21 [KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains
1 2 5 12 ---------------------------||-|----||- 12 [T] COG3605 Signal transduction protein containing GAF and PtsI domains
3 4 5 5 -----------------||--------|--|-----|- 5 [T] COG3614 Predicted periplasmic ligand-binding sensor domain
5 5 5 8 ---------------|---|--|--|----------|- 14 [T] COG3629 DNA-binding transcriptional activator of the SARP family
4 12 14 16 ||||||||||||||------------------------ 16 [T] COG3642 Mn2+-dependent serine/threonine protein kinase
2 5 8 12 ----------------||---------||-|-||--|- 21 [UNTP] COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
5 8 10 14 ---------------|||---|--|--|------|||| 22 [T] COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain
4 7 8 12 -------------------|--|||--|----|--||- 15 [T] COG3707 Response regulator with putative antiterminator output domain
1 3 5 6 ---------------------------||---|--||- 24 [PT] COG3712 Fe2+-dicitrate sensor, membrane component
1 3 4 4 ------------------------------|-|--||- 5 [T] COG3806 Anti-sigma factor
3 5 6 11 --------------|--------||--||---|----- 20 [KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains
5 10 11 16 -||---|||-------------||||-|-----|---- 17 [T] COG3830 ACT domain-containing protein
2 3 6 11 -----------------------||--||-||------ 11 [KT] COG3835 Sugar diacid utilization regulator
3 4 4 7 ---|------------||------|------------- 7 [T] COG3848 Phosphohistidine swiveling domain
1 2 6 12 ---------------------------||-||||---- 16 [T] COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific
1 1 3 6 ----------------------------|-||------ 8 [T] COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific
1 3 7 14 ---------------------------||||-|--||- 14 [T] COG3852 Signal transduction histidine kinase, nitrogen specific
1 3 4 9 -----------------------||||----------- 9 [T] COG3887 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain
1 3 4 6 ---------------------------||---|---|- 12 [TQ] COG3916 N-acyl-L-homoserine lactone synthetase
6 9 10 15 |-|-------------||-|--|||----------||- 109 [T] COG3920 Signal transduction histidine kinase
2 3 3 3 ------------------|----||------------- 4 [T] COG3947 Response regulator containing CheY-like receiver and SARP domains
1 3 4 6 ---------------------------|--|-|---|- 14 [T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system
1 1 3 3 ----------------------------|-||------ 3 [T] COG4192 Signal transduction histidine kinase regulating phosphoglycerate transport system
2 3 3 3 -----------------------||----------|-- 7 [KT] COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component
2 3 3 3 ---|------------||-------------------- 4 [T] COG4250 Predicted sensor protein/domain
3 5 5 5 ----------------|||--------|--------|- 7 [T] COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase)
3 6 7 7 ----------------|||--------|----|--||- 21 [T] COG4252 Predicted transmembrane sensor domain
1 2 2 4 -----------------------||------------- 4 [OTK] COG4512 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide
1 3 3 4 ------------------------------|-|---|- 4 [T] COG4564 Signal transduction histidine kinase
3 3 5 9 ----------------------|-||--|-|------- 19 [KT] COG4565 Response regulator of citrate/malate metabolism
1 3 6 9 ---------------------------||--||--||- 18 [T] COG4566 Response regulator
1 3 5 8 ---------------------------|-|--|--||- 10 [TK] COG4567 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
1 2 3 7 ---------------------------||---|----- 7 [T] COG4579 Isocitrate dehydrogenase kinase/phosphatase
5 9 11 20 ----------------|||---||||-|----|--||- 62 [T] COG4585 Signal transduction histidine kinase
1 2 3 6 ---------------------------||---|----- 6 [KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain
3 3 3 3 -----------|----|-------------------|- 3 [TK] COG4725 Transcriptional activator, adenine-specific DNA methyltransferase
2 2 3 7 -------------------|----||------------ 16 [T] COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain
1 1 2 7 ------------------------||------------ 9 [OTN] COG4862 Negative regulator of genetic competence, sporulation and motility
2 3 3 3 -----------------------||---|--------- 3 [TK] COG4936 Predicted sensor domain
1 2 4 7 ---------------------------|||------|- 12 [T] COG4943 Predicted signal transduction protein containing sensor and EAL domains
5 7 7 8 |-|-----|-------|-----|||------------- 17 [KT] COG4978 Transcriptional regulator, effector-binding domain/component
1 1 2 6 ----------------------------|-|------- 6 [T] COG4999 Uncharacterized domain of BarA-like signal transduction histidine kinases
2 3 6 11 --------------|-----------------||-||| 11 [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation
1 2 3 3 --------------------------------|--||- 3 [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain
2 2 3 8 ------------------|-----||------------ 8 [T] COG5002 Signal transduction histidine kinase
2 3 3 3 -----------|||------------------------ 22 [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family
2 3 3 3 -----------|||------------------------ 6 [DKT] COG5035 Cell cycle control protein
2 3 3 3 -----------|||------------------------ 6 [TG] COG5037 Gluconate transport-inducing protein
2 3 3 3 -----------|||------------------------ 5 [T] COG5040 14-3-3 family protein
2 3 3 3 -----------|||------------------------ 5 [TDK] COG5041 Casein kinase II, beta subunit
2 3 3 3 -----------|||------------------------ 5 [DT] COG5057 Phosphotyrosyl phosphatase activator
3 4 4 4 -----------|||--|--------------------- 19 [TZDR] COG5126 Ca2+-binding protein (EF-Hand superfamily)
2 3 3 3 -----------|||------------------------ 3 [UT] COG5130 Prenylated rab acceptor 1 and related proteins
2 3 3 3 -----------|||------------------------ 3 [T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit
2 3 3 3 -----------||---------------|--------- 3 [T] COG5212 Low-affinity cAMP phosphodiesterase
2 3 3 3 -----------|||------------------------ 3 [TA] COG5238 Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport
2 3 3 3 -----------|||------------------------ 5 [T] COG5253 Phosphatidylinositol-4-phosphate 5-kinase
2 3 3 3 -----------|||------------------------ 4 [DT] COG5261 Protein involved in regulation of cellular morphogenesis/cytokinesis
4 5 6 7 ----------------|-|-----|-------|--||- 12 [T] COG5278 Predicted periplasmic ligand-binding sensor domain
2 3 3 3 -----------|||------------------------ 11 [T] COG5329 Phosphoinositide polyphosphatase (Sac family)
2 3 3 3 -----------|||------------------------ 8 [T] COG5408 SPX domain-containing protein
2 3 3 3 -----------|||------------------------ 6 [T] COG5409 EXS domain-containing protein
2 3 3 3 -----------|||------------------------ 8 [T] COG5411 Phosphatidylinositol 5-phosphate phosphatase
2 3 3 3 -----------|||------------------------ 5 [T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
2 3 3 3 -----------|||------------------------ 3 [T] COG5432 RING-finger-containing E3 ubiquitin ligase
2 3 4 4 --|--------------------|||------------ 14 [T] COG5585 NAD+--asparagine ADP-ribosyltransferase
2 3 3 3 -----------|||------------------------ 6 [T] COG5599 Protein tyrosine phosphatase
3 4 4 4 --|-------------||------------------|- 22 [T] COG5635 Predicted NTPase (NACHT family)