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14 28 38 66 |||||||||||||||||||||||||||||||||||||| 120 [R] COG0073 EMAP domain
10 21 28 44 ||||-|-||--||--||||-|-||||-||-|||||||| 111 [R] COG0110 Acetyltransferase (isoleucine patch superfamily)
6 12 17 28 ||--||--||-|----||----|----||-||||--|- 37 [R] COG0121 Predicted glutamine amidotransferase
7 17 25 47 -|||-|||---|--||---|---||||||||||||||| 47 [R] COG0218 Predicted GTPase
12 19 27 52 -----------||||||||||||||||||||||||||| 52 [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase
9 14 17 27 --|--|---|-|||--|--|--||||-|---||--||- 40 [R] COG0300 Short-chain dehydrogenases of various substrate specificities
9 19 27 40 |||-|||||||---|||||---|||--|||||||-||- 102 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs
10 16 24 50 --------------|||||||||||||||||||||||| 53 [R] COG0313 Predicted methyltransferases
10 16 24 50 --------------|||||||||||||||||||||||| 50 [R] COG0319 Predicted metal-dependent hydrolase
10 16 23 43 --|--------||-||||||--||||-||||||||||- 44 [R] COG0325 Predicted enzyme with a TIM-barrel fold
6 10 17 31 -----------||-|-|||---|----|||||||-||| 31 [R] COG0354 Predicted aminomethyltransferase related to GcvT
5 12 12 18 |||--|||------|-|||---------|-----|--- 24 [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)
8 14 18 28 --||-------||---||||--|||--||-|||--||- 43 [R] COG0384 Predicted epimerase, PhzC/PhzF homolog
7 10 13 24 --|--------|--|-||----|-|--||---||-||- 36 [R] COG0385 Predicted Na+-dependent transporter
11 22 30 48 |-|||||-|||||-|||||--|||||-||||-|||||- 126 [R] COG0388 Predicted amidohydrolase
7 10 10 15 -||-----------||||----|-|---|---|----- 15 [R] COG0390 ABC-type uncharacterized transport system, permease component
6 9 13 23 -----------||---|||-|---||-|||------|| 30 [R] COG0400 Predicted esterase
10 23 30 42 |||||||||||||-|||||---||||-|||-||-|||- 96 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
4 6 9 14 -----------|-|--||---------||-|-||---- 16 [R] COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold
7 12 18 33 ---|-------||---|||---|-|||||-||||-||- 59 [R] COG0431 Predicted flavoprotein
9 19 25 34 |||||||||||---|||||---|-||-||--||--||- 71 [R] COG0433 Predicted ATPase
4 10 11 14 -|-|-||||-|-----||----------|-------|- 14 [R] COG0434 Predicted TIM-barrel enzyme
12 25 32 50 |||||||||||||-||||||-||||||||-|||--||- 171 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases
13 26 36 58 |||||||-|||||||||||||-|||||||||||||||| 542 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
12 26 35 54 ||||||||||||||||||||--|||||||||||||||- 112 [R] COG0456 Acetyltransferases
13 25 33 53 |||||||--|-|||||||||||-|||-||||||||||| 510 [R] COG0457 FOG: TPR repeat
14 28 38 65 |||||||||||||||||||||||||||||||||||||| 537 [GEPR] COG0477 Permeases of the major facilitator superfamily
10 17 25 48 -----------||-||||||||-||||||||||||||| 48 [R] COG0486 Predicted GTPase
10 17 25 48 -----------|||--|||||||||||||||||||||| 159 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains
12 25 34 56 ||||||||||||||||||||--||||-||||||||||- 271 [R] COG0491 Zn-dependent hydrolases, including glyoxylases
12 19 26 42 --|-||--|-||||||-||--|||||-||||-|-|||| 77 [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
14 24 34 57 |-|||-|-||||||||||||||||||-||||||||||| 335 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
10 19 26 38 ||||--|||-||--|||||-||-----||||||||||- 41 [R] COG0496 Predicted acid phosphatase
14 27 37 61 ||||||||||||||||||||||||||-||||||||||| 786 [QR] COG0500 SAM-dependent methyltransferases
11 19 25 41 ---||---||-||||-|||-|-|||||||||||-|-|- 407 [RTKL] COG0515 Serine/threonine protein kinase
13 26 36 59 |||||||||||||-||||||||||||-||||||||||| 330 [R] COG0517 FOG: CBS domain
9 14 19 32 --|--------||-|-||||--|-|--||||-|||||- 67 [R] COG0523 Putative GTPases (G3E family)
9 20 23 29 |||||||||||---|||||---||||-|----|---|- 98 [R] COG0535 Predicted Fe-S oxidoreductases
11 18 26 52 -----------||-|||||||||||||||||||||||| 52 [R] COG0536 Predicted GTPase
13 26 36 63 |||||||-|||||||-|||||||||||||||||||||| 108 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
9 19 26 46 |-||-||----|--|-|||--||||||||||||||||- 91 [R] COG0546 Predicted phosphatases
13 25 31 55 |-||||||||||||-||||||||||||-|-||||--|- 171 [R] COG0561 Predicted hydrolases of the HAD superfamily
8 16 21 35 ----|||---|----|||-|--|||-|||||-|||||- 44 [R] COG0579 Predicted dehydrogenase
9 18 25 41 |-|||||--||||----|-||-|-||-||-|||||-|| 70 [ER] COG0591 Na+/proline symporter
8 17 20 38 ||||-|-|-------|||||--|||||-------|||| 55 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily
12 22 32 55 --|||-|-|||||||-||||-||||||||||||||||| 481 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
6 18 27 43 |||||||||||---|-||-----||--||||||||||| 47 [R] COG0603 Predicted PP-loop superfamily ATPase
9 14 21 35 --|||---||-||-|-|-|---|-||-||||||--||- 139 [CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases
11 17 25 43 --------|-|||-||||||-|||||-||||||-|||| 91 [R] COG0612 Predicted Zn-dependent peptidases
8 15 20 26 ||||--|--||---|||||----||--||-||||---- 34 [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family)
11 19 21 33 -|||-||||-|---||||||-||||||---|------- 48 [R] COG0618 Exopolyphosphatase-related proteins
9 18 23 35 ||||-||||||||--|---|-||||||||-|------- 48 [R] COG0622 Predicted phosphoesterase
5 8 13 28 -----------|----||----|-||-||--|||-||- 52 [R] COG0627 Predicted esterase
10 20 28 50 ||||-||-------||||||-|||||-||||||||||| 128 [R] COG0628 Predicted permease
10 18 26 44 --|-||--||-||--||||-|-||||||||||||-||- 109 [R] COG0637 Predicted phosphatase/phosphohexomutase
6 11 12 17 |||---|--|-----|||-----|----|--|----|- 37 [R] COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)
6 8 9 11 ---|----------|-|||---|----|-------||- 13 [R] COG0645 Predicted kinase
9 17 23 33 |||---||-|-||-|---||--||||-||||-|--||| 82 [R] COG0655 Multimeric flavodoxin WrbA
9 15 20 37 ---|||--||||||-|-|----||||-||---|--||- 96 [R] COG0656 Aldo/keto reductases, related to diketogulonate reductase
10 16 24 47 --------------|||||||||||||||||||||||| 47 [R] COG0658 Predicted membrane metal-binding protein
7 15 22 34 |-|||----|-||---||----|||--|||||||-||| 52 [R] COG0661 Predicted unusual protein kinase
8 18 24 37 |||-||-|-|----|-|||---|||--||||-|||||| 54 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily
11 16 23 32 ----|---|--|||--||||-|||---||||||||||| 96 [R] COG0666 FOG: Ankyrin repeat
8 15 22 39 -----------||---||||||-||||||-|||||||| 51 [R] COG0670 Integral membrane protein, interacts with FtsH
10 21 27 43 |-||||-|||-||-|||||---||||-||-|||-|||- 229 [R] COG0673 Predicted dehydrogenases and related proteins
9 17 24 34 ||-----|---||-||||-|--||||-||||||-|||| 50 [R] COG0679 Predicted permeases
11 24 32 48 -||||||||||||-|-||||-||||||||||||-|||- 110 [R] COG0693 Putative intracellular protease/amidase
14 25 35 57 |-|||||-||||||||||||||||||-||||||||||| 386 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
7 11 12 19 -----------|||--|||---|-|--||---|-|--- 44 [R] COG0699 Predicted GTPases (dynamin-related)
7 14 15 21 |||---||------||||----||||--|-----|--- 26 [R] COG0701 Predicted permeases
11 23 31 48 -||||||||||||-|||||--|||||-||||||-|||- 69 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
10 21 27 42 |||||||||||---|||||--||||--||||-|--||- 105 [R] COG0714 MoxR-like ATPases
5 8 8 9 -----------|||--||---|--------|---|--- 121 [R] COG0724 RNA-binding proteins (RRM domain)
6 14 18 27 -|||-||-||------|||------|-||||-|-|-|- 43 [R] COG0727 Predicted Fe-S-cluster oxidoreductase
10 14 21 39 --------------||||||||||---||||||||||| 41 [R] COG0728 Uncharacterized membrane protein, putative virulence factor
10 22 31 48 |||||||||||---||||||--||||-||||||||||- 153 [R] COG0730 Predicted permeases
8 14 16 25 -|||-||-------|----||||-||----||-||--- 43 [R] COG0733 Na+-dependent transporters of the SNF family
6 10 19 33 --------|-|---||||------||-||||||||||| 34 [R] COG0780 Enzyme related to GTP cyclohydrolase I
4 8 13 24 -----------|||----|--------||-|||||||- 93 [R] COG0790 FOG: TPR repeat, SEL1 subfamily
7 11 18 32 ---------------|||||||-----||||||||||| 66 [R] COG0795 Predicted permeases
10 16 24 46 --------------|||||||||||||||||||||||| 46 [R] COG0802 Predicted ATPase or kinase
9 15 22 41 --------------||||||-||||||||||||||||- 46 [R] COG0820 Predicted Fe-S-cluster redox enzyme
10 18 26 43 |-|||---|||---|-||||-||||--||||||||||- 80 [R] COG0824 Predicted thioesterase
5 9 12 22 ---|--|---------|||---|----||-||-||--- 23 [R] COG0857 BioD-like N-terminal domain of phosphotransacetylase
11 20 27 44 ||||-|-|||-|||-||-|--|||||-||-||||-||- 134 [R] COG1011 Predicted hydrolase (HAD superfamily)
3 11 11 13 |||||||||--||------------------------- 13 [R] COG1019 Predicted nucleotidyltransferase
5 6 6 8 -----------||-----|-||-|-------------- 11 [R] COG1026 Predicted Zn-dependent peptidases, insulinase-like
13 23 33 57 --|||||-|||||||||||||-||||-||||||||||| 825 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
5 11 11 13 -|||-|||-------|-----|--|--|------|--- 19 [R] COG1033 Predicted exporters of the RND superfamily
9 14 22 40 --------------||||||-|||||-||||||||||| 43 [R] COG1040 Predicted amidophosphoribosyltransferases
9 16 24 40 ----||--|||||-|-||-|-|-|||-||-|||||||- 92 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases
6 9 15 29 ----------------|||-|-|-||-||||-|--||| 29 [R] COG1054 Predicted sulfurtransferase
10 17 23 39 ---||||-||||---|||||--||||--|-|-||-||- 40 [R] COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA
11 20 22 32 |||||-|||-|---|||||||-|||---|-|---|--- 57 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes
9 18 26 41 --|||||--||||--||-|---||||||||||||-||- 159 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
7 13 19 36 --|-|---|||||---||----|-||-|||--|||-|- 83 [R] COG1064 Zn-dependent alcohol dehydrogenases
12 19 25 38 --||-||---||||-||-|||-||||-||||||--||- 89 [R] COG1073 Hydrolases of the alpha/beta superfamily
7 12 14 16 ------|----||---|||---|||-||-||-|----- 24 [R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold
7 15 18 27 |||||||||||--|||---|----|||----------- 34 [R] COG1078 HD superfamily phosphohydrolases
8 14 16 27 ---|-||-|-|----||-|--|-|||||----|---|- 42 [R] COG1079 Uncharacterized ABC-type transport system, permease component
4 12 14 16 ||||||||||||||------------------------ 16 [R] COG1084 Predicted GTPase
5 6 9 21 ----|-----------||----|-|--|||-|------ 21 [R] COG1090 Predicted nucleoside-diphosphate sugar epimerase
9 13 19 35 -|---|-|--|---||--|||---||-|||||||--|- 48 [R] COG1092 Predicted SAM-dependent methyltransferases
4 12 14 16 ||||||||||||||------------------------ 19 [R] COG1094 Predicted RNA-binding protein (contains KH domains)
2 5 5 5 ||----||--------|--------------------- 7 [R] COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold
8 17 19 21 |||||||||||||||-|||-----------------|- 114 [R] COG1100 GTPase SAR1 and related small G proteins
4 6 8 13 -------------------|--|--|-|--|-|---|| 13 [R] COG1101 ABC-type uncharacterized transport system, ATPase component
1 5 5 5 |||---||------------------------------ 6 [R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes
5 6 6 8 -|---|---|------|--|--------------|--- 14 [R] COG1106 Predicted ATPases
7 15 16 26 |||-|--|-|------||-|--|-|---|-|-|-|-|- 72 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase
8 12 19 33 --------------||||||||-----||||||||||| 33 [R] COG1137 ABC-type (unclassified) transport system, ATPase component
9 15 23 48 --------------||||||-||||||||||||||||| 48 [R] COG1159 GTPase
10 16 24 50 --------------|||||||||||||||||||||||| 52 [R] COG1160 Predicted GTPases
10 18 21 31 -||--|-|||||||-|||-|-|-||||---|--|---- 51 [R] COG1161 Predicted GTPases
9 14 20 37 --|-----------||||-|-|||||||||||||--|- 40 [R] COG1162 Predicted GTPases
4 12 14 16 ||||||||||||||------------------------ 19 [R] COG1163 Predicted GTPase
5 14 18 27 |||||||||||-----|-----|----||---|--||- 38 [R] COG1201 Lhr-like helicases
1 6 6 7 ||||-|-|------------------------------ 7 [R] COG1202 Superfamily II helicase, archaea-specific
7 11 15 20 |||--||-|||---||---|----||--|--|------ 28 [R] COG1203 Predicted helicases
6 15 17 20 |||||||||||||||-------------|-------|- 26 [R] COG1204 Superfamily II helicase
8 15 16 21 |||--|||||-||---|-|---|-|---|-------|- 27 [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
7 14 18 25 |-|-|||---|-----|||---||---|||-||--||- 54 [R] COG1216 Predicted glycosyltransferases
1 5 5 5 |||---||------------------------------ 5 [R] COG1223 Predicted ATPase (AAA+ superfamily)
12 24 29 44 ||||||||||||||-||||-||||||--|--||--||- 66 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
9 20 24 40 ||||||||----|-|-||-|||-|||-||---|--||| 55 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
4 9 9 10 |||--|||-------|-------|----|--------- 20 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II
6 8 10 18 -|-----|------||---|---|||--|-|------- 18 [R] COG1242 Predicted Fe-S oxidoreductase
2 9 9 11 ||||||||---------------|-------------- 11 [R] COG1244 Predicted Fe-S oxidoreductase
4 12 14 16 ||||||||||||||------------------------ 16 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
12 20 28 52 --||-------||-|||||||||||||||||||||||| 103 [R] COG1253 Hemolysins and related proteins containing CBS domains
12 19 24 37 |-||-|--|-|---||||||||||||-||-|-|--||- 104 [R] COG1266 Predicted metal-dependent membrane protease
10 16 18 28 |-||-||--------|||||||||||----------|| 34 [R] COG1268 Uncharacterized conserved protein
8 12 17 33 -----------|||----||-|||||-||||--|-||- 38 [R] COG1272 Predicted membrane protein, hemolysin III homolog
8 17 18 27 --|||||--||----||||--|-||-||----|---|- 64 [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
4 8 12 22 -------------------|--|||--||-|||-|-|| 25 [R] COG1279 Lysine efflux permease
3 6 14 32 ---------------------|--||-||||||||||| 32 [R] COG1286 Uncharacterized membrane protein, required for colicin V production
4 11 12 14 |||||||-||-||---------------------|--- 26 [R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation
9 18 21 27 |-|||||||||||||-|||---|----||---|----- 56 [R] COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily
5 10 11 12 |||--||||-|---||-------|-------------- 13 [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins
4 8 9 14 ||-----|-------|---|---||||----------- 16 [R] COG1323 Predicted nucleotidyltransferase
1 7 7 8 ||||-|||------------------------------ 9 [R] COG1326 Uncharacterized archaeal Zn-finger protein
3 7 9 10 -|---||||||||------------------------- 12 [R] COG1341 Predicted GTPase or GTP-binding protein
3 7 7 8 |||--||----------------|------|------- 10 [R] COG1342 Predicted DNA-binding proteins
4 8 10 12 |-|-|||-|||---||---------------------- 15 [R] COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)
6 12 13 14 |||-||||||----||------|-|------------- 18 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs)
6 13 15 17 |||-|||||||||-||--------------------|- 18 [R] COG1355 Predicted dioxygenase
1 4 4 5 ||---|-|------------------------------ 5 [R] COG1365 Predicted ATPase (PP-loop superfamily)
7 12 15 19 -||-||--||-----|---|--|-||-----|--|-|| 53 [R] COG1373 Predicted ATPase (AAA+ superfamily)
5 9 14 23 --|--|------------||---|||-||-||||--|- 30 [R] COG1380 Putative effector of murein hydrolase LrgA
9 18 20 30 |||-||||---||-||--||--||||--|-|-----|- 40 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family
7 10 16 30 --------------|||||---||||-|||||||---- 30 [R] COG1399 Predicted metal-binding, possibly nucleic acid-binding protein
7 11 14 19 ||-|---||||----|||----|-|----------||- 24 [R] COG1402 Uncharacterized protein, putative amidase
3 10 13 18 |||||||||||------------------------||- 22 [R] COG1407 Predicted ICC-like phosphoesterases
9 14 15 24 |-|-----|-----|-|-|-|-||||--|---|-|-|- 30 [R] COG1408 Predicted phosphohydrolases
9 18 24 39 |-|--||||-|||-|-||--|-||||-||-|||--||- 75 [R] COG1409 Predicted phosphohydrolases
1 5 5 5 |||---||------------------------------ 5 [R] COG1411 Uncharacterized protein related to proFAR isomerase (HisA)
4 12 14 16 ||||||||||||||------------------------ 19 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
8 19 20 36 ||||||||------||--||-|-||||-|-----|-|- 51 [R] COG1418 Predicted HD superfamily hydrolase
7 8 9 13 ----|-|-|-|---|---|-|---|---------|--- 13 [R] COG1427 Predicted periplasmic solute-binding protein
4 12 14 16 ||||||||||||||------------------------ 16 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
5 9 13 19 ---|-|||||||||--------------|-||------ 23 [R] COG1444 Predicted P-loop ATPase fused to an acetyltransferase
7 16 22 34 ||||-||-------|---||--||--|||||-|||||| 43 [R] COG1451 Predicted metal-dependent hydrolase
4 6 6 6 |-|------------|||-----|-------------- 16 [R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family
3 8 8 9 |||--|||--|---|----------------------- 9 [R] COG1458 Predicted DNA-binding protein containing PIN domain
5 7 8 18 ---------------|--||--|||||----------- 22 [R] COG1461 Predicted kinase related to dihydroxyacetone kinase
9 17 21 35 --||||---|-----|||||--||||-||--||-|||- 89 [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase
6 8 8 10 ---------------|||-|||-||------------- 10 [R] COG1480 Predicted membrane-associated HD superfamily hydrolase
4 6 6 7 -----|||--|----|--------------------|- 9 [R] COG1483 Predicted ATPase (AAA+ superfamily)
4 7 13 23 -----------||-----|---|----||||-||-||| 25 [R] COG1485 Predicted ATPase
6 12 17 21 -||--||-||------|||---|-----||-||--||| 84 [R] COG1487 Predicted nucleic acid-binding protein, contains PIN domain
7 12 18 26 |---|-|-|||---||||-----||--||-||---||- 26 [R] COG1489 DNA-binding protein, stimulates sugar fermentation
5 8 12 16 ---------------|||---|--||-||--||--||- 23 [R] COG1512 Beta-propeller domains of methanol dehydrogenase type
9 15 17 21 ----|||--|-|||-||-----|||--|-|----|||- 34 [R] COG1524 Uncharacterized proteins of the AP superfamily
1 4 4 4 ||----||------------------------------ 4 [R] COG1532 Predicted RNA-binding protein
4 12 14 16 ||||||||||||||------------------------ 18 [R] COG1537 Predicted RNA-binding proteins
6 9 13 22 -----|------------||--|-|--||-|||||-|- 26 [R] COG1540 Uncharacterized proteins, homologs of lactam utilization protein B
4 11 13 16 |||||||||||-----------|------------|-- 48 [R] COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon
9 15 21 40 ---|----------||||||--|||||||||-|||||- 46 [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced)
7 11 19 39 --------------|---||-|||||-||||||||||| 39 [R] COG1559 Predicted periplasmic solute-binding protein
2 4 4 5 -|---||-------|----------------------- 6 [R] COG1568 Predicted methyltransferases
3 6 6 7 -|---||---------||-----------|-------- 10 [R] COG1569 Predicted nucleic acid-binding protein, contains PIN domain
2 9 11 13 |||||||||||--------------------------- 17 [R] COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
9 14 16 24 --||||----|---||--||--|-|--||---|--||- 33 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold
7 7 7 13 --------------|---|-||||----------|--- 13 [R] COG1579 Zn-ribbon protein, possibly nucleic acid-binding
8 12 15 28 ----|------||--||||---||||-||------||- 46 [IR] COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
4 9 9 9 |||---||-------|||-----|-------------- 11 [R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily
2 9 11 13 |||||||||||--------------------------- 13 [R] COG1608 Predicted archaeal kinase
12 19 27 43 --|-||||||-|--|||-|||-|-||-||||||||||- 56 [R] COG1611 Predicted Rossmann fold nucleotide-binding protein
4 5 5 8 ---------------|---|--|||------------- 8 [R] COG1623 Predicted nucleic-acid-binding protein (contains the HHH domain)
2 9 11 13 |||||||||||--------------------------- 13 [R] COG1634 Uncharacterized Rossmann fold enzyme
2 7 9 10 -|||-||||||--------------------------- 10 [R] COG1645 Uncharacterized Zn-finger containing protein
3 10 12 17 |||||||||||-------------|------------- 18 [R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold
3 3 3 6 ---------------|-----|--|------------- 9 [R] COG1647 Esterase/lipase
5 7 13 27 ------------------||--||||-|||||||---- 27 [R] COG1660 Predicted P-loop-containing kinase
4 11 12 18 |-||||||--|-------------|---|-|-----|- 18 [R] COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif
5 8 9 9 -||---|--------|-||--------------|-||- 24 [R] COG1669 Predicted nucleotidyltransferases
6 11 12 13 |||--|--||-----|||-|--------|-----|--- 91 [R] COG1672 Predicted ATPase (AAA+ superfamily)
5 10 10 10 |||---||-------|||----||-------------- 10 [R] COG1691 NCAIR mutase (PurE)-related proteins
12 18 27 43 --|--||||||---||||||||||||-|||||---||| 60 [R] COG1694 Predicted pyrophosphatase
1 4 4 4 ||----||------------------------------ 4 [R] COG1707 ACT domain-containing protein
6 13 17 19 |||--||||||---||-------||---|--|----|| 91 [R] COG1708 Predicted nucleotidyltransferases
4 9 9 9 |||---|||------|-----------|----|----- 9 [R] COG1712 Predicted dinucleotide-utilizing enzyme
3 6 6 6 |||----|------|--|-------------------- 22 [R] COG1719 Predicted hydrocarbon binding protein (contains V4R domain)
10 17 20 29 --|||||-|-|---|||||--||-|--|--|-|--||- 47 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
5 7 7 12 ---------|--------|---|-|-|-|-------|- 13 [R] COG1735 Predicted metal-dependent hydrolase with the TIM-barrel fold
6 10 14 24 --|-|---|-------||----||---||-|||--||- 45 [R] COG1741 Pirin-related protein
8 14 16 28 ---|-||-|-|----||-|--|-|||||----|---|- 54 [R] COG1744 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein
1 6 6 6 ||||--||------------------------------ 9 [R] COG1745 Predicted metal-binding protein
2 5 7 8 -||--||-|||--------------------------- 9 [R] COG1750 Archaeal serine proteases
10 13 20 31 -----------|||||-|-|-||-||-||||-||-||| 68 [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily
5 7 9 16 ----------------|||--||------|-----||| 16 [R] COG1754 Uncharacterized C-terminal domain of topoisomerase IA
2 7 8 9 |||--|||||---------------------------- 15 [R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)
3 3 3 4 ------------------|-|--|-------------- 4 [R] COG1768 Predicted phosphohydrolase
4 6 11 19 --|-----------|----|-------||||||||--- 19 [R] COG1778 Low specificity phosphatase (HAD superfamily)
3 10 12 14 |||-|||||||||------------------------- 14 [R] COG1779 C4-type Zn-finger protein
2 9 11 13 |||||||||||--------------------------- 14 [R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain
3 3 4 5 ---------------------|--||-----|------ 7 [R] COG1783 Phage terminase large subunit
1 3 3 3 -|---||------------------------------- 6 [R] COG1800 Predicted transglutaminase-like proteases
6 7 7 12 ------|--------|--||---||---|--------- 13 [R] COG1811 Uncharacterized membrane protein, possible Na+ channel or pump
3 7 9 10 ||---|||||||-------------------------- 17 [R] COG1818 Predicted RNA-binding protein, contains THUMP domain
1 5 5 5 |||---||------------------------------ 5 [R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)
3 4 6 12 ---------------------|--|---|-||--|--- 13 [R] COG1823 Predicted Na+/dicarboxylate symporter
4 6 7 10 |------|-------|---|---|||------------ 14 [R] COG1827 Predicted small molecule binding protein (contains 3H domain)
2 8 10 11 ||||-||||||--------------------------- 11 [R] COG1829 Predicted archaeal kinase (sugar kinase superfamily)
2 9 10 12 |||||||||-|--------------------------- 12 [R] COG1831 Predicted metal-dependent hydrolase (urease superfamily)
7 12 15 27 ---|||--|||---||--|-----||--|---|-|-|- 27 [R] COG1832 Predicted CoA-binding protein
10 12 13 23 --------------||||||||||||--------|--- 25 [R] COG1837 Predicted RNA-binding protein (contains KH domain)
7 9 10 17 ---------------|||||-|||||------------ 17 [R] COG1847 Predicted RNA-binding protein
5 7 9 11 -|---||-|||-------|---|-------------|- 87 [R] COG1848 Predicted nucleic acid-binding protein, contains PIN domain
11 19 27 44 |-|-|||-|||-|-||||||--||||-||--|||-||| 100 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family
2 9 11 13 |||||||||||--------------------------- 13 [R] COG1855 ATPase (PilT family)
7 16 18 25 |||||||-||-----|||----|-|--|---||---|- 30 [R] COG1878 Predicted metal-dependent hydrolase
8 18 23 37 |-|||||--|-|--|-----|-|||-|-|||||||-|| 44 [R] COG1881 Phospholipid-binding protein
6 12 18 29 ---|-||||||||-----|-----|--||-||--|||- 31 [R] COG1896 Predicted hydrolases of HD superfamily
2 7 8 9 |||--|||-||--------------------------- 13 [R] COG1907 Predicted archaeal sugar kinases
3 7 9 10 -|-|-||||||---|----------------------- 12 [R] COG1913 Predicted Zn-dependent proteases
5 8 14 25 -|------------||-------||--|||||||-||- 25 [R] COG1923 Uncharacterized host factor I protein
5 8 8 12 --|-|---------|-|-----|---------|-|-|- 16 [R] COG1926 Predicted phosphoribosyltransferases
2 9 11 13 |||||||||||--------------------------- 17 [R] COG1938 Archaeal enzymes of ATP-grasp superfamily
5 9 13 26 |-----|---------|-----|-||--||--|||||- 33 [R] COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog
3 9 11 14 |||-|||||||-----------|--------------- 16 [R] COG1964 Predicted Fe-S oxidoreductases
4 10 12 20 |||--|||--|------------||--||--|------ 35 [R] COG1988 Predicted membrane-bound metal-dependent hydrolases
9 21 25 32 |||||||||||---|||||---|||-----|-|||||- 43 [R] COG1994 Zn-dependent proteases
7 11 17 23 ---|----|-|||-|---|-----|--|-||-|||||| 37 [R] COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems
2 4 4 4 ||-----|-------|---------------------- 4 [R] COG2000 Predicted Fe-S protein
3 9 13 20 |-|---||||-----------------||--||-|||- 22 [R] COG2005 N-terminal domain of molybdenum-binding protein
5 8 8 10 ||----||------|---|---|----------|---- 19 [R] COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid
8 14 19 29 --|||-|-|||---|-|-|---|-|--||--||-|||- 43 [R] COG2041 Sulfite oxidase and related enzymes
4 7 8 8 ||----||||----|------------|---------- 13 [R] COG2044 Predicted peroxiredoxins
6 11 11 12 ||--|--|-------||||----||-------|----- 12 [HR] COG2045 Phosphosulfolactate phosphohydrolase and related enzymes
1 8 8 10 ||||||||------------------------------ 10 [R] COG2047 Uncharacterized protein (ATP-grasp superfamily)
1 5 5 5 |||---||------------------------------ 5 [R] COG2054 Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases
3 5 7 13 -------------------|----|--|--||-||--- 15 [R] COG2056 Predicted permease
6 9 12 18 |------||||-------|---|-|---|---|--||- 20 [R] COG2068 Uncharacterized MobA-related protein
10 14 18 30 ------|----|--|||-||--||||-|-|--|||||- 53 [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase
5 8 12 22 ------------|------|--||||-||-----|||| 26 [R] COG2071 Predicted glutamine amidotransferases
6 9 12 21 |---|---||||----------|-|--||---|---|- 29 [R] COG2079 Uncharacterized protein involved in propionate catabolism
3 7 12 24 ----------------||-----|||-||-|||--||- 31 [R] COG2081 Predicted flavoproteins
5 12 12 14 ||||--||--------|-----|--|---|--|---|- 18 [R] COG2085 Predicted dinucleotide-binding enzymes
2 5 6 7 -|---||||-|--------------------------- 7 [R] COG2100 Predicted Fe-S oxidoreductase
4 12 14 16 ||||||||||||||------------------------ 21 [R] COG2102 Predicted ATPases of PP-loop superfamily
4 7 10 18 ----------------|||----|||--|-||----|- 20 [R] COG2103 Predicted sugar phosphate isomerase
7 8 10 14 ----|-|-|||---|---|-|---|---------|--- 14 [R] COG2107 Predicted periplasmic solute-binding protein
3 8 10 11 -|||-||||||------------|-------------- 11 [R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme
10 16 20 27 --|-||||||||--||--||--|-||-||---|---|- 33 [R] COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1
3 11 13 15 |||||||||||||------------------------- 15 [R] COG2118 DNA-binding protein
4 9 11 12 |||--||||||---|---------------------|- 15 [R] COG2129 Predicted phosphoesterases, related to the Icc protein
5 8 10 14 ---|-------||---|-------|--||---|--||- 16 [R] COG2130 Putative NADP-dependent oxidoreductases
7 10 15 29 ---------------|--||-|||||-||-||||--|- 29 [R] COG2137 Uncharacterized protein conserved in bacteria
4 8 8 11 --|--||----------|------|---|---|---|- 14 [GR] COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes
2 5 5 5 |||----|---------|-------------------- 8 [R] COG2144 Selenophosphate synthetase-related proteins
8 13 17 27 --|||---||--|---|||---|-|--|||--|--||- 51 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases
1 6 6 8 |-|||||------------------------------- 12 [R] COG2150 Predicted regulator of amino acid metabolism, contains ACT domain
7 14 19 32 |||-||-||||----|--|---|-||--||--|--||- 43 [R] COG2151 Predicted metal-sulfur cluster biosynthetic enzyme
5 6 9 14 ------------|----|----|-||-||-|-----|- 14 [R] COG2153 Predicted acyltransferase
2 6 6 6 |||---||---------------|-------------- 6 [R] COG2158 Uncharacterized protein containing a Zn-finger-like domain
6 9 11 17 ---|-|-|-||------|----|||----------||- 30 [R] COG2159 Predicted metal-dependent hydrolase of the TIM-barrel fold
5 7 12 22 ----------------|||-|-|----|||||---||- 27 [R] COG2166 SufE protein probably involved in Fe-S center assembly
4 5 6 11 ---------------||||-----||------------ 12 [R] COG2179 Predicted hydrolase of the HAD superfamily
1 4 9 20 ---------------------------|||||-||-|| 48 [R] COG2194 Predicted membrane-associated, metal-dependent hydrolase
4 6 7 15 -|-----------------|-|------|--||---|- 17 [R] COG2215 ABC-type uncharacterized transport system, permease component
10 22 30 45 ||||||||||||---|||||--||||-||||||-|-|| 81 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold
6 9 9 11 ||-----|---||-|---|---|----------|---- 12 [R] COG2229 Predicted GTPase
1 5 5 5 |||---||------------------------------ 5 [R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase
7 15 18 24 |-||-|||---||-|-|-----|||--||||----|-- 41 [R] COG2234 Predicted aminopeptidases
7 13 16 22 --|||||-|||||---|----||---------|||--- 30 [R] COG2236 Predicted phosphoribosyltransferases
9 19 26 42 ||||||||-|-----||-||--||||-|||||||-||- 113 [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
2 5 7 8 -|---||||||--------------------------- 8 [R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)
5 10 15 26 --|---------|------|---||-|||-|||||||- 56 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B)
4 5 5 9 -----|---------|||----|--------------- 9 [R] COG2251 Predicted nuclease (RecB family)
10 18 24 40 -|-|-|------|--|||||-||||||||-|||||||- 69 [R] COG2252 Permeases
11 19 28 46 -|||-|-||||---|||||||-||||-|||||||-||- 49 [R] COG2262 GTPases
5 7 8 16 -----------||-|-------|||----------||- 17 [R] COG2270 Permeases of the major facilitator superfamily
9 12 15 21 --|---|--||-----||||-||-|--||-|-----|- 35 [R] COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain
5 5 6 8 ---|--------------|---|-|----------||- 9 [R] COG2312 Erythromycin esterase homolog
3 3 3 3 ------|--------|--|------------------- 3 [R] COG2316 Predicted hydrolase (HD superfamily)
8 11 12 15 --|--------|||-|||||----------|----||- 289 [R] COG2319 FOG: WD40 repeat
4 6 8 17 ------------------|---|--|-||--||---|- 19 [R] COG2321 Predicted metalloprotease
6 9 10 20 ---||----||-------|---|-|--|----|---|- 34 [R] COG2329 Conserved protein involved in polyketide biosynthesis related to monooxygenase
5 7 13 24 ---|------------|-|----|||-|||||||---- 30 [R] COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily)
6 8 12 21 --|--------------|||----|--||-|-||-||- 33 [R] COG2334 Putative homoserine kinase type II (protein kinase fold)
3 4 5 10 ---------------|--|----|||------------ 11 [R] COG2344 AT-rich DNA-binding protein
5 7 8 16 -----------------||---|-|-------|-|||- 20 [R] COG2346 Truncated hemoglobins
4 7 9 16 ------------|-----|-----|--||---|-|||- 17 [R] COG2351 Transthyretin-like protein
6 8 11 13 ---|--|---|------||-----|--|--||----|| 21 [R] COG2358 TRAP-type uncharacterized transport system, periplasmic component
5 9 12 13 ----|-|-|||-----|||--------|----|--||- 20 [R] COG2366 Protein related to penicillin acylase
4 6 6 13 ------------------|---|-|---|---|---|- 13 [R] COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC
5 7 12 19 ---------------||-||-------|||-||--||| 23 [R] COG2373 Large extracellular alpha-helical protein
6 7 8 8 ----------------|||--||--|-|--|------- 8 [R] COG2374 Predicted extracellular nuclease
3 5 6 13 ------------------|----||||---|------- 13 [R] COG2384 Predicted SAM-dependent methyltransferase
7 8 13 19 ------|---|-------||--|-||-||-||---||- 20 [R] COG2388 Predicted acetyltransferase
4 5 5 5 --|-----------|-|||------------------- 5 [R] COG2389 Uncharacterized metal-binding protein
6 11 15 23 ---||--|||-----|--|-----|--||||-|-|-|- 48 [R] COG2391 Predicted transporter component
3 5 5 6 -----|||--|-----------------|--------- 7 [R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain
5 8 8 8 ---|-||-|-----|-||----|--------------- 13 [R] COG2402 Predicted nucleic acid-binding protein, contains PIN domain
3 5 6 7 |----|-||-|------|-------------------- 8 [R] COG2403 Predicted GTPase
5 6 7 9 --||-----||--------|----|---------|--- 9 [R] COG2404 Predicted phosphohydrolase (DHH superfamily)
3 4 4 4 ------|---|-----||-------------------- 6 [R] COG2405 Predicted nucleic acid-binding protein, contains PIN domain
3 4 6 6 |-|-----|||----|---------------------- 6 [R] COG2406 Protein distantly related to bacterial ferritins
5 6 8 14 ----|---|||-------|---|||------------- 49 [R] COG2409 Predicted drug exporters of the RND superfamily
2 4 5 6 -----|||-||--------------------------- 7 [R] COG2413 Predicted nucleotidyltransferase
3 5 8 12 -||----||||-----------------|-|------- 15 [R] COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain
3 5 6 8 ----------------|-------|||----|--|--- 8 [R] COG2503 Predicted secreted acid phosphatase
7 12 14 15 --|--|||||-----|-|-|---|||----|----|-- 16 [R] COG2509 Uncharacterized FAD-dependent dehydrogenases
5 5 7 14 --------|-|-------|---|-||----------|- 17 [R] COG2514 Predicted ring-cleavage extradiol dioxygenase
5 6 6 7 --|--|---|----||-|-------------------- 7 [R] COG2516 Biotin synthase-related enzyme
1 4 4 5 |----|||------------------------------ 5 [R] COG2517 Predicted RNA-binding protein containing a C-terminal EMAP domain
4 12 14 16 ||||||||||||||------------------------ 32 [R] COG2520 Predicted methyltransferase
3 5 6 7 -|---|-||-|------------------|-------- 7 [R] COG2521 Predicted archaeal methyltransferase
2 5 7 8 --||-||-|||--------------------------- 13 [R] COG2522 Predicted transcriptional regulator
2 3 4 7 -|-------------------------||-----|--- 8 [R] COG2603 Predicted ATPase
5 5 5 7 ----|------------|----||----------|--- 9 [R] COG2605 Predicted kinase related to galactokinase and mevalonate kinase
4 8 10 14 --------------|-||-----|---|----|||||- 14 [R] COG2607 Predicted ATPase (AAA+ superfamily)
2 3 5 12 -----------------------|----|-||--|--- 21 [R] COG2704 Anaerobic C4-dicarboxylate transporter
3 5 5 6 -----------------|-----||--|----|----- 6 [R] COG2715 Uncharacterized membrane protein, required for spore maturation in B.subtilis.
3 4 4 7 ---------------|--|----||------------- 8 [R] COG2738 Predicted Zn-dependent protease
3 5 5 5 |-|---|--------|-------|-------------- 6 [R] COG2768 Uncharacterized Fe-S center protein
5 8 10 14 ------------|---|||---|----|--|-|--||- 14 [R] COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease
3 7 10 12 ------------------|----|||-||----||||- 13 [R] COG2819 Predicted hydrolase of the alpha/beta superfamily
3 5 10 17 ------------------|----|---||-||||--|| 28 [R] COG2823 Predicted periplasmic or secreted lipoprotein
4 5 6 8 ----------------|-|-----|---|--|-|---- 9 [R] COG2842 Uncharacterized ATPase, putative transposase
8 13 16 21 --|-||--||||---|--||---||--|--|-|---|- 28 [R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain
2 4 5 8 ----------------------|-------|--|-||- 9 [R] COG2907 Predicted NAD/FAD-binding protein
2 5 7 11 ------------------------||-|--|-|-|-|- 11 [R] COG2910 Putative NADH-flavin reductase
1 1 5 11 ---------------------------|||||------ 11 [R] COG2915 Uncharacterized protein involved in purine metabolism
1 2 5 11 ----------------------------|||||----- 23 [R] COG2916 DNA-binding protein H-NS
1 1 4 9 ---------------------------|||-|------ 9 [R] COG2933 Predicted SAM-dependent methyltransferase
4 5 7 10 -----------------|----|-||---|-----||- 16 [R] COG2936 Predicted acyl esterases
5 8 8 9 --|--------|||------|--------|--|---|- 22 [R] COG2940 Proteins containing SET domain
2 5 9 14 ---|--|--------------------|-|--||-||| 14 [R] COG2945 Predicted hydrolase of the alpha/beta superfamily
1 3 10 19 ---------------------------|||||||-||| 19 [R] COG2961 Protein involved in catabolism of external DNA
3 5 9 20 ----------------------|-|--||-|||--||- 24 [R] COG2962 Predicted permeases
1 2 7 13 ---------------------------|||||||---- 13 [R] COG2969 Stringent starvation protein B
6 8 10 16 --------------|----||-|--|-|--|-|---|| 17 [R] COG2984 ABC-type uncharacterized transport system, periplasmic component
4 4 6 11 ---|---------------|--|-----|-||------ 17 [R] COG2985 Predicted permease
2 3 4 7 -------------------|--------|-|---|--- 7 [R] COG2992 Uncharacterized FlgJ-related protein
1 2 6 12 ---------------------------||-||||---- 19 [R] COG3008 Paraquat-inducible protein B
3 5 7 7 --------|-----|------------|--||--|-|- 8 [R] COG3019 Predicted metal-binding protein
4 7 10 21 --||------------------|-|--||-||-|--|- 22 [R] COG3030 Protein affecting phage T7 exclusion by the F plasmid
2 4 6 11 ------|---------------------|-|-||--|- 12 [R] COG3042 Putative hemolysin
3 4 4 4 -|-----|--|-------------------|------- 4 [R] COG3044 Predicted ATPase of the ABC class
3 5 6 6 |--|-------------|------------|----||- 6 [R] COG3046 Uncharacterized protein related to deoxyribodipyrimidine photolyase
1 1 3 8 ----------------------------|-||------ 8 [R] COG3054 Predicted transcriptional regulator
1 1 4 9 ---------------------------||-||------ 9 [R] COG3081 Nucleoid-associated protein
1 1 4 9 ---------------------------||-||------ 10 [R] COG3083 Predicted hydrolase of alkaline phosphatase superfamily
4 5 10 13 ----------------|--|--|----|||||---||- 21 [R] COG3093 Plasmid maintenance system antidote protein
1 2 4 12 ----------------------------|-||----|- 12 [R] COG3106 Predicted ATPase
1 1 5 10 ---------------------------|||||------ 10 [R] COG3107 Putative lipoprotein
1 2 6 12 ----------------------------||||||---- 12 [R] COG3113 Predicted NTP binding protein (contains STAS domain)
2 2 4 8 ------------|--------------||-|------- 8 [R] COG3129 Predicted SAM-dependent methyltransferase
1 2 4 8 ---------------------------||-|-----|- 8 [R] COG3136 Uncharacterized membrane protein required for alginate biosynthesis
1 2 5 9 ---------------------------||-|||----- 15 [R] COG3150 Predicted esterase
5 6 10 18 --|-------------|-----|-||-||-|----||- 32 [R] COG3153 Predicted acetyltransferase
5 8 11 16 --||--------------|---|-||-|----|--||| 24 [R] COG3173 Predicted aminoglycoside phosphotransferase
3 5 7 11 ----------------|-----|----|--|-|--||- 14 [R] COG3176 Putative hemolysin
1 3 6 10 ---------------------------|-|--||-||- 10 [R] COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases
2 3 5 5 ------------------|--------||--|----|- 8 [R] COG3179 Predicted chitinase
5 6 8 15 ----------------|--|--|-|--||-|-----|- 15 [R] COG3180 Putative ammonia monooxygenase
3 6 8 10 ----------------||----|----|--|-|--||- 15 [ER] COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins
4 6 9 12 --------||-------|------|--||---|--||- 16 [R] COG3193 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol
3 5 7 9 ----------------|-------|--|--|---|||- 12 [R] COG3211 Predicted phosphatase
3 4 7 13 ---|------------|----------||-|----||- 13 [R] COG3217 Uncharacterized Fe-S protein
1 3 5 8 ---------------------------|-|----|||- 8 [R] COG3218 ABC-type uncharacterized transport system, auxiliary component
3 5 5 8 -|---|----------------|----|----|----- 8 [R] COG3233 Predicted deacetylase
2 3 7 7 ----------------|----------||||||----- 9 [IR] COG3240 Phospholipase/lecithinase/hemolysin
2 3 4 10 ------------------|--------||-------|- 10 [R] COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization
2 8 8 9 |||||-|||----------------------------- 20 [R] COG3269 Predicted RNA-binding protein, contains TRAM domain
2 5 6 7 |-|------------------------|----|||--- 18 [R] COG3271 Predicted double-glycine peptidase
4 8 9 9 |||--||---|-------------||----|------- 87 [R] COG3291 FOG: PKD repeat
2 3 4 9 --------------|-------------|--|----|- 19 [R] COG3302 DMSO reductase anchor subunit
1 3 6 12 ---------------------------||-|-|--||- 16 [R] COG3313 Predicted Fe-S protein
3 4 6 11 --------------------|---|--||-|--|---- 12 [R] COG3318 Predicted metal-binding protein related to the C-terminal domain of SecA
4 6 10 15 --|-------------------|-|--||-|||--||- 25 [R] COG3324 Predicted enzyme related to lactoylglutathione lyase
4 5 5 6 ----------------||----|-|----------|-- 7 [R] COG3329 Predicted permease
1 2 3 11 ------------------------|||----------- 13 [R] COG3331 Penicillin-binding protein-related factor A, putative recombinase
3 5 5 5 -----------||--|-------||------------- 6 [R] COG3341 Predicted double-stranded RNA/RNA-DNA hybrid binding protein
1 5 5 5 |-||--||------------------------------ 5 [R] COG3364 Zn-ribbon containing protein
2 4 4 6 ----|||--|---------------------------- 7 [R] COG3368 Predicted permease
6 7 9 14 ---|-----|------|-----|-||--||--|----- 16 [R] COG3378 Predicted ATPase
3 5 5 5 ---|------------||---------|----|----- 5 [R] COG3380 Predicted NAD/FAD-dependent oxidoreductase
3 4 6 11 ---|-----|------------------|-|||----- 27 [R] COG3381 Uncharacterized component of anaerobic dehydrogenases
4 5 5 10 |---|----|--------------|-----------|- 12 [R] COG3383 Uncharacterized anaerobic dehydrogenase
6 6 6 8 --|-------------|----||-|----------|-- 8 [R] COG3393 Predicted acetyltransferase
2 2 2 5 ------------------------|---------|--- 8 [R] COG3401 Fibronectin type 3 domain-containing protein
2 4 5 6 ---||-|-||---------------------------- 35 [R] COG3413 Predicted DNA binding protein
1 2 3 10 ----------------------------|-|---|--- 10 [R] COG3417 Collagen-binding surface adhesin SpaP (antigen I/II family)
3 5 6 11 ----------------||----||||------------ 11 [R] COG3442 Predicted glutamine amidotransferase
2 3 4 11 ------------------------||--|-------|- 11 [R] COG3443 Predicted periplasmic or secreted protein
1 1 3 8 ----------------------------|-||------ 8 [R] COG3445 Acid-induced glycyl radical enzyme
3 4 5 7 ---------------||----------||-------|- 20 [R] COG3450 Predicted enzyme of the cupin superfamily
6 12 14 17 |-|||-----------|-||---|||--|---||--|- 27 [R] COG3467 Predicted flavin-nucleotide-binding protein
3 4 5 5 -||----------------|----||------------ 5 [R] COG3478 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain
4 6 7 12 -|-----|-----------|---|||----------|- 15 [R] COG3481 Predicted HD-superfamily hydrolase
1 2 3 5 ---------------------------|--|-----|- 5 [R] COG3489 Predicted periplasmic lipoprotein
2 5 7 7 ------------|--------------||---|-|||- 11 [R] COG3491 Isopenicillin N synthase and related dioxygenases
2 4 6 10 ----------------|----------|||--|---|- 12 [R] COG3497 Phage tail sheath protein FI
1 2 4 6 ---------------------------|||--|----- 8 [R] COG3498 Phage tail tube protein FII
1 3 5 7 ---------------------------|||--|---|- 8 [R] COG3499 Phage protein U
2 4 6 10 ----------------|----------|||--|---|- 12 [R] COG3500 Phage protein D
1 1 3 5 ---------------------------||-|------- 5 [R] COG3529 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain
4 7 7 7 -|--------------|------||--|----|---|- 10 [R] COG3541 Predicted nucleotidyltransferase
3 5 6 11 ------------------|-----|--|----|--||- 16 [R] COG3545 Predicted esterase of the alpha/beta hydrolase fold
2 3 5 6 ----------------|------------|||----|- 8 [R] COG3549 Plasmid maintenance system killer protein
3 5 9 13 -------------------|--|-----|-||||-||- 17 [R] COG3550 Uncharacterized protein related to capsule biosynthesis enzymes
4 5 5 7 |---------|-----------|---------|---|- 10 [R] COG3552 Protein containing von Willebrand factor type A (vWA) domain
3 6 7 10 -----------|-----------|||-|-----|--|- 11 [R] COG3560 Predicted oxidoreductase related to nitroreductase
2 3 3 4 -----------------|---------|--------|- 4 [R] COG3565 Predicted dioxygenase of extradiol dioxygenase family
2 4 8 15 ------------------------||-|||--|--||- 21 [R] COG3568 Metal-dependent hydrolase
2 3 3 5 ----------------------|----|--------|- 5 [R] COG3571 Predicted hydrolase of the alpha/beta-hydrolase fold
3 3 3 6 ------------------|---|-------------|- 6 [R] COG3573 Predicted oxidoreductase
7 10 11 15 |||-------------|-||--|--|-|-------||- 23 [R] COG3576 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase
1 2 4 8 ---------------------------|-------||| 11 [R] COG3577 Predicted aspartyl protease
2 4 4 4 ---|--|----||------------------------- 7 [R] COG3582 Predicted nucleic acid binding protein containing the AN1-type Zn-finger
2 5 6 8 ----------------||----------|-|--||--- 12 [R] COG3596 Predicted GTPase
3 3 4 8 ----------------------|-||----------|- 8 [R] COG3607 Predicted lactoylglutathione lyase
2 5 6 9 |--|---|-------------------|--|-----|- 15 [R] COG3608 Predicted deacylase
1 4 5 8 ---------------------------||---|-|-|- 13 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold
3 4 4 5 ----------------|-------|-----|------| 5 [R] COG3621 Patatin
2 4 6 7 ----------------|----------|||--|---|- 9 [R] COG3628 Phage baseplate assembly protein W
5 7 8 10 --||--------------|---|-|--|-------||- 18 [R] COG3631 Ketosteroid isomerase-related protein
3 3 4 6 -------------------|-|--||------------ 8 [R] COG3641 Predicted membrane protein, putative toxin regulator
3 6 9 10 ----------------|--------||||-|--|-||- 10 [R] COG3654 Prophage maintenance system killer protein
4 6 10 16 ----------------|-|---|----||||-|--||- 54 [R] COG3668 Plasmid stabilization system protein
3 4 5 10 -------------------|-|------|--|----|- 10 [R] COG3683 ABC-type uncharacterized transport system, periplasmic component
2 4 4 5 ----------------------|----|----|--|-- 7 [R] COG3687 Predicted metal-dependent hydrolase
2 4 5 8 ----------------||-----|||------------ 8 [R] COG3688 Predicted RNA-binding protein containing a PIN domain
4 5 5 6 ----------------||||-----|------------ 7 [R] COG3694 ABC-type uncharacterized transport system, permease component
2 2 3 6 -------------------------|--|--|------ 6 [R] COG3700 Acid phosphatase (class B)
1 1 4 8 ---------------------------||-||------ 8 [R] COG3726 Uncharacterized membrane protein affecting hemolysin expression
3 4 5 8 ----------------|-------|--||------|-- 13 [R] COG3729 General stress protein
3 5 7 10 ----------------------|-||--|---|--||- 14 [R] COG3740 Phage head maturation protease
3 3 3 7 -----|----|-----------------|--------- 7 [R] COG3769 Predicted hydrolase (HAD superfamily)
3 5 8 12 ----------------|------|----||--|--||| 43 [R] COG3772 Phage-related lysozyme (muraminidase)
2 3 4 8 ----------------|-----------|-|----|-- 8 [R] COG3788 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily
2 2 3 8 ----------------------|------------||- 14 [R] COG3800 Predicted transcriptional regulator
1 2 3 3 -----------------------------|-----||- 3 [R] COG3818 Predicted acetyltransferase, GNAT superfamily
2 3 4 7 ------------------------|---|--|----|- 7 [R] COG3822 ABC-type sugar transport system, auxiliary component
8 14 16 27 ---|-||-|-|----||-|--|-|||||----|---|- 41 [R] COG3845 ABC-type uncharacterized transport systems, ATPase components
2 3 3 4 -----------------------||----|-------- 10 [R] COG3858 Predicted glycosyl hydrolase
4 5 5 7 ----------------|-|----||-----------|- 8 [R] COG3871 Uncharacterized stress protein (general stress protein 26)
3 4 4 6 ---------------|---|---||------------- 6 [R] COG3872 Predicted metal-dependent enzyme
2 2 4 5 -----|--|||--------------------------- 5 [R] COG3889 Predicted solute binding protein
2 3 3 4 --|---|-----------------------------|- 8 [R] COG3894 Uncharacterized metal-binding protein
2 4 5 11 -----------------|---------||---|---|- 11 [R] COG3895 Predicted periplasmic protein
2 4 5 8 -----------||--------------|-------||- 11 [R] COG3897 Predicted methyltransferase
6 7 7 8 ------------|---|--|--||-|----------|- 26 [R] COG3899 Predicted ATPase
2 2 2 5 ----------------------|-------------|- 17 [R] COG3903 Predicted ATPase
1 1 3 3 ---------------------------|||-------- 3 [R] COG3907 PAP2 (acid phosphatase) superfamily protein
4 4 4 5 --|-------------------|-|-----------|- 6 [R] COG3910 Predicted ATPase
1 2 3 4 ------------------------------|----||- 4 [R] COG3911 Predicted ATPase
2 2 2 3 -------------------------|----------|- 3 [R] COG3919 Predicted ATP-grasp enzyme
1 3 3 6 ----------------------------|----|--|- 10 [R] COG3926 Putative secretion activating protein
2 3 4 5 ----------------||-----------------||- 7 [R] COG3932 Uncharacterized ABC-type transport system, permease components
2 3 3 3 -----------------------||---|--------- 3 [R] COG3940 Predicted beta-xylosidase
1 1 4 5 ---------------------------||-||------ 5 [R] COG3941 Mu-like prophage protein
2 2 3 5 ------------------------||---------|-- 20 [R] COG3942 Surface antigen
1 2 3 5 ---------------------------||----|---- 5 [R] COG3943 Virulence protein
1 2 4 4 ---------------------------|||--|----- 6 [R] COG3948 Phage-related baseplate assembly protein
1 2 3 3 ----------------------------|-|-----|- 4 [R] COG3950 Predicted ATP-binding protein involved in virulence
2 3 4 6 ----------------------||||------------ 9 [R] COG3953 SLT domain proteins
1 2 2 4 -----------------------||------------- 4 [R] COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain
1 3 4 8 ---------------------------||---|---|- 8 [R] COG3960 Glyoxylate carboligase
5 7 8 10 --|--------||---------||||--|--------- 17 [GHR] COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes
1 2 2 3 ----------------------------|-------|- 4 [R] COG3964 Predicted amidohydrolase
3 3 3 3 -----------------||----|-------------- 3 [R] COG3968 Uncharacterized protein related to glutamine synthetase
2 3 5 9 ------------------------||-||---|----- 12 [R] COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase
2 3 4 6 ---------|------------------|------||- 6 [R] COG3970 Fumarylacetoacetate (FAA) hydrolase family protein
1 2 4 4 ---------------------------|||------|- 5 [R] COG3972 Superfamily I DNA and RNA helicases
3 4 4 4 ------------------|---|||------------- 5 [R] COG3973 Superfamily I DNA and RNA helicases
3 5 7 8 ---------|------||--------------||-|-| 10 [R] COG3975 Predicted protease with the C-terminal PDZ domain
3 3 6 8 ---|--------------------||-||-|------- 17 [R] COG3979 Uncharacterized protein contain chitin-binding domain type 3
5 7 9 11 ------------------||--||||----||----|- 14 [R] COG3981 Predicted acetyltransferase
1 3 3 3 |-----||------------------------------ 3 [R] COG4001 Predicted metal-binding protein
1 4 4 4 |||----|------------------------------ 4 [R] COG4002 Predicted phosphotransacetylase
1 3 3 3 ||-----|------------------------------ 6 [R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase
1 3 3 3 ||-----|------------------------------ 3 [R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family
1 3 3 3 |----|-|------------------------------ 3 [R] COG4026 Uncharacterized protein containing TOPRIM domain, potential nuclease
2 3 4 5 -----|-|-||--------------------------- 5 [R] COG4028 Predicted P-loop ATPase/GTPase
1 4 4 4 --||--||------------------------------ 4 [R] COG4031 Predicted metal-binding protein
1 4 4 4 |||----|------------------------------ 4 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein
1 3 3 4 -|---|-|------------------------------ 4 [R] COG4049 Uncharacterized protein containing archaeal-type C2H2 Zn-finger
1 4 4 4 |||----|------------------------------ 4 [R] COG4052 Uncharacterized protein related to methyl coenzyme M reductase subunit C
1 3 3 3 ||-----|------------------------------ 3 [R] COG4076 Predicted RNA methylase
2 4 4 5 ||-----|----------------|------------- 5 [R] COG4085 Predicted RNA-binding protein, contains TRAM domain
1 4 4 4 |||----|------------------------------ 6 [R] COG4087 Soluble P-type ATPase
2 3 4 4 ---------------|------------|--|----|- 4 [R] COG4099 Predicted peptidase
2 5 12 25 --------------|------------||||||||||| 25 [R] COG4105 DNA uptake lipoprotein
3 4 5 12 ------------------|---|----||-------|- 12 [R] COG4106 Trans-aconitate methyltransferase
3 3 3 5 ------------------|----|----|--------- 6 [R] COG4110 Uncharacterized protein involved in stress response
1 2 3 6 ---------------------------------|-||- 7 [R] COG4111 Uncharacterized conserved protein
2 2 2 3 ---------------|--------|------------- 3 [R] COG4112 Predicted phosphoesterase (MutT family)
5 6 7 8 -----|--||------||----|-------------|- 24 [R] COG4113 Predicted nucleic acid-binding protein, contains PIN domain
2 3 3 7 ------------------------|---|-------|- 7 [R] COG4114 Uncharacterized Fe-S protein
2 2 2 4 ----------------------|-------------|- 4 [LR] COG4119 Predicted NTP pyrophosphohydrolase
4 6 8 13 -------------------|--|--|-|--|-|---|| 13 [R] COG4120 ABC-type uncharacterized transport system, permease component
10 15 16 25 --||------|-|-|-||||--||||-|-----|--|- 33 [R] COG4122 Predicted O-methyltransferase
5 9 13 29 --------------||---|---||||-|-||--|||- 30 [R] COG4123 Predicted O-methyltransferase
1 1 3 3 ---------------------------||-|------- 3 [R] COG4128 Zonula occludens toxin
1 3 3 6 ---------------------------|------|-|- 6 [R] COG4132 ABC-type uncharacterized transport system, permease component
1 2 3 8 ----------------------------|-|-----|- 8 [R] COG4134 ABC-type uncharacterized transport system, periplasmic component
1 2 3 5 ----------------------------|-|-----|- 5 [R] COG4135 ABC-type uncharacterized transport system, permease component
1 2 3 5 ----------------------------|-|-----|- 5 [R] COG4136 ABC-type uncharacterized transport system, ATPase component
1 2 7 12 ---------------------------|||||||---- 13 [R] COG4137 ABC-type uncharacterized transport system, permease component
2 2 3 6 ------------------------|---|--|------ 6 [R] COG4146 Predicted symporter
7 8 11 16 ------|-------|-|-|---|-|--||||-|----- 16 [R] COG4147 Predicted symporter
3 4 5 9 -||---------------------||---------|-- 9 [R] COG4152 ABC-type uncharacterized transport system, ATPase component
1 2 3 5 ----------------------------|--|----|- 6 [R] COG4158 Predicted ABC-type sugar transport system, permease component
2 4 6 13 -------------------|-------||-|-|---|- 23 [R] COG4172 ABC-type uncharacterized transport system, duplicated ATPase component
1 4 6 14 ---------------------------||-|-|-|-|- 15 [R] COG4174 ABC-type uncharacterized transport system, permease component
4 7 9 17 -----------|----||----|-----|--|||--|- 25 [R] COG4178 ABC-type uncharacterized transport system, permease and ATPase components
4 4 4 4 -|------------|-------|-------------|- 4 [R] COG4186 Predicted phosphoesterase or phosphohydrolase
3 6 7 7 ----------------||------|--|----|--||- 11 [R] COG4188 Predicted dienelactone hydrolase
4 5 5 5 ----|----|------------|||------------- 6 [R] COG4194 Predicted membrane protein
3 3 3 4 ----------------------|-|-----------|- 7 [R] COG4195 Phage-related replication protein
8 13 19 32 ---|-------||---||||--|-||-||||||||-|- 45 [R] COG4221 Short-chain alcohol dehydrogenase of unknown specificity
2 4 4 6 -----------------------||---|-------|- 9 [R] COG4225 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins
1 2 3 5 ----------------------------|--|-|---- 6 [R] COG4228 Mu-like prophage DNA circulation protein
2 5 7 15 ---------------------|-----||-|-|-|-|- 16 [R] COG4239 ABC-type uncharacterized transport system, permease component
3 4 4 4 -----------||---|------------------|-- 4 [R] COG4240 Predicted kinase
2 3 3 6 ----------------|-----------|-----|--- 8 [R] COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain
3 3 3 5 ----------------|-|---------|--------- 5 [R] COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains
2 3 3 3 ----------------|------------|------|- 15 [R] COG4249 Uncharacterized protein containing caspase domain
1 2 3 4 ----------------------------||--|----- 5 [R] COG4258 Predicted exporter
1 2 3 4 ----------------------------||--|----- 5 [R] COG4261 Predicted acyltransferase
3 3 3 5 --------------|-------|---------|----- 6 [R] COG4262 Predicted spermidine synthase with an N-terminal membrane domain
4 4 5 5 |------------------|---|-----------||- 5 [R] COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif
2 3 4 4 ---------------|------------||--|----- 4 [R] COG4287 PhoPQ-activated pathogenicity-related protein
2 3 3 4 -----------------------|----------|-|- 4 [R] COG4310 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain
1 3 3 6 ---------------------------|----|---|- 9 [R] COG4321 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis
1 3 3 3 ---------------------------|----|---|- 3 [R] COG4324 Predicted aminopeptidase
3 3 3 3 ----------------|-------|-----|------- 3 [R] COG4326 Sporulation control protein
2 4 4 4 ----------------|----------|----|---|- 5 [R] COG4341 Predicted HD phosphohydrolase
2 2 3 3 ------------------|---------|--|------ 3 [R] COG4373 Mu-like prophage FluMu protein gp28
1 2 3 5 ----------------------------|--|-|---- 6 [R] COG4379 Mu-like prophage tail protein gpP
1 3 5 5 ---------------------------|||--|---|- 7 [R] COG4385 Bacteriophage P2-related tail formation protein
1 2 3 5 ----------------------------|--|-|---- 5 [R] COG4386 Mu-like prophage tail sheath protein gpL
1 2 3 4 ----------------------------|--|-|---- 4 [R] COG4388 Mu-like prophage I protein
1 2 3 3 ----------------------------|--|-|---- 3 [R] COG4396 Mu-like prophage host-nuclease inhibitor protein Gam
1 2 3 3 ----------------------------|--|-|---- 3 [R] COG4397 Mu-like prophage major head subunit gpT
2 2 3 3 -----------------------|----|--|------ 3 [R] COG4416 Mu-like prophage protein Com
2 4 4 4 ----------------||---------|-------|-- 4 [R] COG4447 Uncharacterized protein related to plant photosystem II stability/assembly factor
2 3 3 3 ----------------||-----------------|-- 3 [R] COG4449 Predicted protease of the Abi (CAAX) family
1 2 3 4 ---------------------------||-------|- 4 [R] COG4455 Protein of avirulence locus involved in temperature-dependent protein secretion
1 1 2 7 ------------------------||------------ 7 [R] COG4469 Competence protein
2 3 3 5 -------------------|---||------------- 5 [R] COG4492 ACT domain-containing protein
3 3 4 10 ------------------|-----|---|-|------- 18 [R] COG4533 ABC-type uncharacterized transport system, periplasmic component
1 2 4 5 ---------------------------|||--|----- 7 [R] COG4540 Phage P2 baseplate assembly protein gpV
2 4 4 4 ----------------|----------|----|---|- 4 [R] COG4551 Predicted protein tyrosine phosphatase
4 4 5 6 ----------------|--|--|-||------------ 6 [R] COG4552 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases
2 3 3 6 ----------------|-----------|--------| 7 [R] COG4572 Putative cation transport regulator
1 2 3 7 ---------------------------||--------| 7 [R] COG4574 Serine protease inhibitor ecotin
5 7 7 8 -----------||---||||-----|------------ 9 [R] COG4586 ABC-type uncharacterized transport system, ATPase component
4 5 5 6 ----------------||||-----|------------ 7 [R] COG4587 ABC-type uncharacterized transport system, permease component
1 3 4 5 ----------------------------|-|---|-|- 6 [R] COG4588 Accessory colonization factor AcfC, contains ABC-type periplasmic domain
2 3 6 9 -------------------|-------||-||----|- 9 [R] COG4589 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase
1 1 3 3 ---------------------------||-|------- 3 [R] COG4590 ABC-type uncharacterized transport system, permease component
8 14 16 27 ---|-||-|-|----||-|--|-|||||----|---|- 43 [R] COG4603 ABC-type uncharacterized transport system, permease component
2 3 6 9 --------------|------------||------||| 18 [R] COG4618 ABC-type protease/lipase transport system, ATPase and permease components
2 3 3 6 ------------------------|---|---|----- 6 [R] COG4619 ABC-type uncharacterized transport system, ATPase component
4 5 5 5 -----------|||-|-------|-------------- 8 [R] COG4624 Iron only hydrogenase large subunit, C-terminal domain
2 4 5 8 -----------------------|||--|-------|- 19 [R] COG4626 Phage terminase-like protein, large subunit
2 3 3 3 ----------------|----------|--------|- 5 [R] COG4637 Predicted ATPase
4 7 9 17 ---------------|||----|----||---|--||- 52 [PR] COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit
5 5 5 5 ----------------|-||---|----------|--- 7 [R] COG4639 Predicted kinase
2 4 5 8 ----------------------|-----|---|--||- 12 [R] COG4653 Predicted phage phi-C31 gp36 major capsid-like protein
5 7 9 10 ---|--|---|-------|-----|--|--||----|- 18 [R] COG4666 TRAP-type uncharacterized transport system, fused permease components
4 4 6 10 -------------------|--||----|-||------ 10 [R] COG4667 Predicted esterase of the alpha-beta hydrolase superfamily
2 3 3 5 ----------------||------------------|- 10 [R] COG4671 Predicted glycosyl transferase
5 8 9 11 ----------------|||---|-|--||---|---|- 12 [R] COG4674 Uncharacterized ABC-type transport system, ATPase component
2 3 3 4 ----------------------|------|------|- 5 [R] COG4691 Plasmid stability protein
1 3 3 3 -----------------------------|----|-|- 3 [R] COG4710 Predicted DNA-binding protein with an HTH domain
2 3 3 3 ----------------|-----------|-------|- 3 [R] COG4734 Antirestriction protein
1 3 3 3 |-|----|------------------------------ 3 [R] COG4740 Predicted metalloprotease
1 3 3 3 |-|---|------------------------------- 4 [R] COG4747 ACT domain-containing protein
2 2 3 3 ------|-|-|--------------------------- 3 [R] COG4756 Predicted cation transporter
2 4 4 4 ----------------------|----|----|---|- 5 [R] COG4757 Predicted alpha/beta hydrolase
1 1 2 7 ------------------------||------------ 8 [R] COG4768 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain
3 6 10 15 --------------|-||---------||||-|--||- 15 [R] COG4783 Putative Zn-dependent protease, contains TPR repeats
1 2 2 5 ---------------------------|--------|- 5 [R] COG4784 Putative Zn-dependent protease
1 1 3 8 ----------------------------|-||------ 8 [R] COG4785 Lipoprotein NlpI, contains TPR repeats
2 4 4 6 -------------------|-----------|-|---| 8 [R] COG4797 Predicted regulatory domain of a methyltransferase
2 2 3 3 ----------------|------------------||- 7 [R] COG4798 Predicted methyltransferase
1 4 4 4 --||--||------------------------------ 4 [R] COG4801 Predicted acyltransferase
1 1 2 3 ------------------------||------------ 6 [R] COG4814 Uncharacterized protein with an alpha/beta hydrolase fold
2 2 2 3 ------------------------|-----------|- 5 [R] COG4821 Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain
1 2 2 4 -----------------------||------------- 5 [R] COG4824 Phage-related holin (Lysis protein)
1 3 3 3 |-|----|------------------------------ 5 [R] COG4827 Predicted transporter
1 1 1 4 ------------------------|------------- 4 [R] COG4851 Protein involved in sex pheromone biosynthesis
3 3 3 4 -------------------|----|-----------|- 4 [R] COG4857 Predicted kinase
2 2 2 4 ------------------|---|--------------- 4 [R] COG4867 Uncharacterized protein with a von Willebrand factor type A (vWA) domain
2 3 3 3 -|----|-|----------------------------- 3 [R] COG4880 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats
1 1 3 3 --------|||--------------------------- 3 [R] COG4882 Predicted aminopeptidase, Iap family
1 3 3 3 -||----|------------------------------ 3 [R] COG4887 Uncharacterized metal-binding protein conserved in archaea
3 4 6 6 --------||||||------------------------ 6 [R] COG4888 Uncharacterized Zn ribbon-containing protein
3 3 3 6 ----------------------|-|---------|--- 8 [R] COG4889 Predicted helicase
2 3 3 3 |-|--------------------|-------------- 3 [R] COG4892 Predicted heme/steroid binding protein
1 1 3 3 --------|||--------------------------- 3 [R] COG4900 Predicted metallopeptidase
3 4 4 5 --|-------------------|||------------- 7 [R] COG4908 Uncharacterized protein containing a NRPS condensation (elongation) domain
1 1 3 3 --------|||--------------------------- 3 [R] COG4914 Predicted nucleotidyltransferase
1 1 2 4 ------------------------||------------ 4 [R] COG4915 5-bromo-4-chloroindolyl phosphate hydrolysis protein
3 3 3 3 -------------------|----|-----------|- 3 [R] COG4927 Predicted choloylglycine hydrolase
6 7 7 7 -|-------------||-|---|-----|-------|- 9 [R] COG4928 Predicted P-loop ATPase
9 16 20 34 ---||-||-||----|||||--||||-||---|--||- 116 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily
3 5 6 9 ----------------|||----|||------------ 9 [R] COG4956 Integral membrane protein (PIN domain superfamily)
1 1 2 5 -----------------------------------||- 7 [R] COG4976 Predicted methyltransferase (contains TPR repeat)
2 4 4 7 ----------------||-----||------------- 11 [R] COG4980 Gas vesicle protein
2 4 6 14 -----------------------|||--|-|-----|- 14 [R] COG4989 Predicted oxidoreductase
1 1 3 3 --------|||--------------------------- 3 [R] COG4996 Predicted phosphatase
1 2 3 4 ----------------------------|--|-|---- 4 [R] COG5003 Mu-like prophage protein gp37
1 2 4 4 ---------------------------|||--|----- 5 [R] COG5004 P2-like prophage tail protein X
1 2 3 3 ----------------------------|--|-|---- 5 [R] COG5005 Mu-like prophage protein gpG
3 5 8 12 ------------------|---|----||-|-|--||- 14 [R] COG5006 Predicted permease, DMT superfamily
3 5 5 6 |-|---|------------|----------------|- 21 [R] COG5012 Predicted cobalamin binding protein
3 3 3 3 -------||------|---------------------- 3 [R] COG5014 Predicted Fe-S oxidoreductase
3 3 3 3 ------------|-----------|--|---------- 3 [R] COG5018 Inhibitor of the KinA pathway to sporulation, predicted exonuclease
2 3 3 3 -----------|||------------------------ 7 [R] COG5038 Ca2+-dependent lipid-binding protein, contains C2 domain
2 3 3 3 -----------|||------------------------ 48 [R] COG5048 FOG: Zn-finger
2 3 3 3 -----------|||------------------------ 4 [R] COG5063 CCCH-type Zn-finger protein
3 4 4 4 -----------|||---------|-------------- 4 [R] COG5083 Uncharacterized protein involved in plasmid maintenance
2 3 3 3 -----------|||------------------------ 10 [R] COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins
2 3 3 3 -----------|||------------------------ 3 [R] COG5088 Rad5p-binding protein
2 3 3 3 -----------|||------------------------ 3 [R] COG5091 Suppressor of G2 allele of skp1 and related proteins
2 3 3 3 -----------|||------------------------ 3 [R] COG5109 Uncharacterized conserved protein, contains RING Zn-finger
2 3 3 3 -----------|||------------------------ 3 [R] COG5112 U1-like Zn-finger-containing protein
2 3 3 3 -----------||---|--------------------- 3 [R] COG5119 Uncharacterized protein, contains ParB-like nuclease domain
2 3 3 3 -----------|||------------------------ 3 [DR] COG5124 Protein predicted to be involved in meiotic recombination
3 4 4 4 -----------|||--|--------------------- 19 [TZDR] COG5126 Ca2+-binding protein (EF-Hand superfamily)
2 3 3 3 -----------|||------------------------ 3 [R] COG5129 Nuclear protein with HMG-like acidic region
2 3 3 3 -----------|||------------------------ 3 [R] COG5141 PHD zinc finger-containing protein
2 3 3 3 -----------|||------------------------ 3 [R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers
2 3 3 3 -----------|||------------------------ 3 [R] COG5191 Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat
2 3 3 3 -----------|||------------------------ 3 [R] COG5198 Protein tyrosine phosphatase-like protein (contains Pro instead of catalytic Arg)
2 3 3 3 -----------|||------------------------ 3 [R] COG5209 Uncharacterized protein involved in cell differentiation/sexual development
2 3 3 3 -----------|||------------------------ 25 [R] COG5210 GTPase-activating protein
2 3 3 3 -----------|||------------------------ 3 [R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger
2 3 3 3 -----------|||------------------------ 3 [R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger
2 3 3 3 -----------|||------------------------ 3 [R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger
2 3 3 3 -----------|||------------------------ 3 [R] COG5252 Uncharacterized conserved protein, contains CCCH-type Zn-finger protein
2 4 5 5 |--|--|-||---------------------------- 5 [R] COG5258 GTPase
1 2 2 3 -----------------------|-|------------ 17 [R] COG5263 FOG: Glucan-binding domain (YG repeat)
2 3 3 3 -----------|||------------------------ 3 [R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain
2 3 3 3 -----------|||------------------------ 17 [R] COG5273 Uncharacterized protein containing DHHC-type Zn finger
2 3 3 3 -----------|||------------------------ 3 [R] COG5275 BRCT domain type II
1 2 3 3 ---------------------------||---|----- 4 [R] COG5301 Phage-related tail fibre protein
2 3 3 7 ----------------------|-----|-------|- 7 [R] COG5302 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid
3 4 4 4 -----------|||-----------------------| 12 [R] COG5307 SEC7 domain proteins
3 4 4 4 ----------------|||-------------|----- 4 [R] COG5322 Predicted dehydrogenase
1 1 2 5 ------------------------------------|| 14 [R] COG5342 Invasion protein B, involved in pathogenesis
2 2 2 5 ------------------------|-----------|- 6 [R] COG5350 Predicted protein tyrosine phosphatase
2 3 3 3 -----------|||------------------------ 5 [R] COG5354 Uncharacterized protein, contains Trp-Asp (WD) repeat
3 3 4 4 --|---------------------|-----------|| 4 [R] COG5362 Phage-related terminase
2 3 3 3 -----------|||------------------------ 4 [R] COG5366 Protein involved in propagation of M2 dsRNA satellite of L-A virus
2 3 3 3 -|---|----|--------------------------- 3 [R] COG5378 Predicted nucleotide-binding protein
2 3 3 3 -----------|||------------------------ 13 [UR] COG5391 Phox homology (PX) domain protein
3 4 4 6 ----------------||---|--|------------- 6 [R] COG5401 Spore germination protein
2 3 3 3 -----------|||------------------------ 3 [R] COG5415 Predicted integral membrane metal-binding protein
2 4 4 6 ----------------|----------|----|---|- 6 [R] COG5485 Predicted ester cyclase
7 7 8 8 --|------||----|--||--|--|------------ 8 [R] COG5496 Predicted thioesterase
1 2 3 5 ----------------------------||--|----- 22 [R] COG5511 Bacteriophage capsid protein
4 5 5 8 ---------------||||---|--------------- 8 [R] COG5512 Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives
1 2 2 3 --------------------------------|---|- 4 [R] COG5516 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding
2 3 3 4 ------------------------|---|---|----- 5 [R] COG5518 Bacteriophage capsid portal protein
3 4 4 4 ---|-------||---|--------------------- 9 [R] COG5524 Bacteriorhodopsin
3 4 5 8 ----------------|-------|---||--|----- 24 [R] COG5525 Bacteriophage tail assembly protein
2 3 3 3 --|-------------------------|------|-- 3 [R] COG5529 Pyocin large subunit
1 2 3 7 ---------------------------||---|----- 7 [R] COG5544 Predicted periplasmic lipoprotein
3 3 3 3 ----------------|--------|---|-------- 4 [R] COG5545 Predicted P-loop ATPase and inactivated derivatives
2 3 3 3 ----------------|----------|--------|- 3 [R] COG5553 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily
3 3 4 9 ----------------------|-||--|--------- 11 [R] COG5562 Phage envelope protein
1 2 2 3 ----------------------------|-------|- 6 [R] COG5564 Predicted TIM-barrel enzyme, possibly a dioxygenase
1 2 2 3 -----------------------------|------|- 5 [R] COG5565 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives
3 4 4 4 ----------|-----|---------------|---|- 5 [R] COG5573 Predicted nucleic-acid-binding protein, contains PIN domain
1 2 3 4 ------------------------------||-----| 5 [R] COG5595 Zn-ribbon-containing, possibly nucleic-acid-binding protein
1 2 2 3 ----------------------------|-----|--- 3 [R] COG5610 Predicted hydrolase (HAD superfamily)
2 2 3 3 --------------|---------------------|| 3 [R] COG5611 Predicted nucleic-acid-binding protein, contains PIN domain
2 4 4 5 -----------------------|----|---|---|- 13 [R] COG5614 Bacteriophage head-tail adaptor
1 2 2 4 ----------------------------|-------|- 4 [R] COG5618 Predicted periplasmic lipoprotein
3 4 4 5 ------------------|---|-------|-----|- 6 [R] COG5621 Predicted secreted hydrolase
2 2 3 3 ------------------------|----------|-| 3 [R] COG5628 Predicted acetyltransferase
1 1 3 8 ----------------------------|-||------ 8 [R] COG5633 Predicted periplasmic lipoprotein
1 3 3 3 |-|----|------------------------------ 7 [R] COG5643 Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E
1 1 3 8 ---------------------------||--|------ 12 [R] COG5645 Predicted periplasmic lipoprotein