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9 20 25 36 |||||||||||||-||||----||||-|||------|- 46 [F] COG0005 Purine nucleoside phosphorylase
11 24 32 54 ||||||||||-||-||||||--||||-||||||||||- 67 [F] COG0015 Adenylosuccinate lyase
10 15 23 41 ---||---||-||-|||||---|-||-|||||||-||- 41 [F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)
6 8 11 18 -|---|---|------||----|-|--||-||------ 18 [F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||- 53 [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase
12 21 29 48 |--|-|--|||||-||||||-||||||||-|||||||- 52 [F] COG0035 Uracil phosphoribosyltransferase
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||- 51 [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
11 24 30 48 |||||||||||||-||||||--||||-|||--|-|||- 69 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||- 51 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||- 51 [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
11 24 32 54 ||||||||||-||-||||||--||||-||||||||||- 55 [F] COG0104 Adenylosuccinate synthase
12 25 35 57 |||||||||||||||-|||-||||||-||||||||||| 57 [F] COG0105 Nucleoside diphosphate kinase
14 27 37 65 |||||||||||||||||||||||-|||||||||||||| 70 [F] COG0125 Thymidylate kinase
14 27 36 57 ||||||||||||||||||||||||||-||||||||||- 59 [F] COG0127 Xanthosine triphosphate pyrophosphatase
10 19 26 44 --|||-|----||-||||||--||||-||||||||||- 46 [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||- 51 [F] COG0150 Phosphoribosylaminoimidazole (AIR) synthetase
11 24 32 53 ||||||||||-||-||||||--||||-||||||||||- 53 [F] COG0151 Phosphoribosylamine-glycine ligase
11 24 33 53 ||||||||||-||-||||||--||||-||||||||||| 56 [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
11 24 33 55 |||||||||||||-||||||--||||-||||||||||- 67 [F] COG0167 Dihydroorotate dehydrogenase
11 18 26 51 -----------||||||||||-|||||||||||||||| 53 [F] COG0194 Guanylate kinase
8 17 24 44 |||---||---|||----||--||||||||||||-||- 47 [F] COG0207 Thymidylate synthase
13 19 27 49 ---|-----|-||||--||||||||||||||||||||| 62 [F] COG0208 Ribonucleotide reductase, beta subunit
14 25 35 61 |-|||||-||||||||-||||||||||||||||||||| 88 [F] COG0209 Ribonucleotide reductase, alpha subunit
6 13 15 29 -||--||--------|--|---|||||-|-|-|---|- 30 [F] COG0213 Thymidine phosphorylase
5 7 12 24 -----------------||---|-|--||-|||--||| 28 [F] COG0232 dGTP triphosphohydrolase
11 16 23 38 --|------|-|--||||||--|||--||||||||||| 54 [FP] COG0248 Exopolyphosphatase
10 16 20 39 |--||---|-|---|||||--||||||-|-||----|- 44 [F] COG0274 Deoxyribose-phosphate aldolase
11 16 24 47 -------------|||||||||||||||||||||-||| 48 [F] COG0283 Cytidylate kinase
11 24 33 55 |||||||||||||-||||||--||||-||||||||||- 56 [F] COG0284 Orotidine-5'-phosphate decarboxylase
9 13 18 35 ---|----|-|||--|--|--||||||-|-||---||- 37 [F] COG0295 Cytidine deaminase
11 19 26 44 --|||---|--||-||||||--||||-||||||||||- 45 [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN
10 23 30 42 |||||||||||||-|||||---||||-|||-||-|||- 96 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
3 7 10 19 -----------||----|---------||-|-|||-|- 19 [F] COG0418 Dihydroorotase
11 23 31 51 |||||-||||-||-||||||--||||-||||||||||- 66 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
12 25 34 56 |||||||||||||-|||||||-||||-||||||||||- 59 [F] COG0461 Orotate phosphoribosyltransferase
12 26 36 62 |||||||||||||-||||||-||||||||||||||||| 76 [FE] COG0462 Phosphoribosylpyrophosphate synthetase
11 23 30 54 ||||-|-||||||--|||||-||||||||-|||||-|- 93 [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
13 27 37 63 |||||||||||||||||||-|||||||||||||||||| 67 [F] COG0504 CTP synthase (UTP-ammonia lyase)
11 23 31 51 |||||-||||-||-||||||--||||-||||||||||- 55 [EF] COG0505 Carbamoylphosphate synthase small subunit
13 24 31 53 ||-|||-|--|||-||||||||||||-||||||||||- 138 [F] COG0516 IMP dehydrogenase/GMP reductase
13 26 35 56 |||||||||||||-||||||||||||-||||||||||- 83 [F] COG0518 GMP synthase - Glutamine amidotransferase domain
13 26 35 56 |||||||||||||-||||||||||||-||||||||||- 56 [F] COG0519 GMP synthase, PP-ATPase domain/subunit
12 25 35 63 |||||||||||---|||||||||||||||||||||||| 63 [F] COG0528 Uridylate kinase
13 26 36 63 |||||||-|||||||-|||||||||||||||||||||| 108 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
11 24 32 53 |||||||||||||-||||||--||||-||||-|||||- 53 [F] COG0540 Aspartate carbamoyltransferase, catalytic chain
13 23 31 58 --||-||----||||||||||||||||||||||||||| 85 [F] COG0563 Adenylate kinase and related kinases
9 13 16 29 ---|-------||--||||-||-||||-|-||------ 35 [F] COG0572 Uridine kinase
10 15 23 42 --|--------||||-|||-|-||||-|||||||-||| 65 [FJ] COG0590 Cytosine/adenosine deaminases
7 11 18 38 --------------||--||--||||||||||||-||- 39 [F] COG0634 Hypoxanthine-guanine phosphoribosyltransferase
8 20 28 47 |||||||||||---|-||--|-|||--|||-||||||| 53 [F] COG0717 Deoxycytidine deaminase
10 18 21 33 |--|--|----||-||-||--||||||-|-|||-|-|- 69 [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases
9 14 21 40 -----------||||----|||||||-|||-||||||| 46 [F] COG0756 dUTPase
9 14 20 42 --|------------|--|||||||||||-|||||||- 64 [F] COG0775 Nucleoside phosphorylase
7 11 16 27 ---|----------|-|||---|-|--||||||-|||- 34 [F] COG0788 Formyltetrahydrofolate hydrolase
6 9 12 26 ---------|--------||-|--|||-|-||--|-|- 28 [F] COG0813 Purine-nucleoside phosphorylase
1 6 6 7 |||||-|------------------------------- 8 [F] COG0856 Orotate phosphoribosyltransferase homologs
5 11 11 18 |||---||----------|--|-||---|-------|- 25 [F] COG1001 Adenine deaminase
8 17 24 34 |||--||||||---|-|||---||||-||-|-|--||| 56 [F] COG1051 ADP-ribose pyrophosphatase
3 10 12 15 |||||||||||----------|---------------- 15 [F] COG1102 Cytidylate kinase
5 11 15 24 |||--|-|-------|---|---|||-||-|||----- 27 [F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase
10 14 16 26 ---|||--|||---||||--||||----------|--| 26 [F] COG1351 Predicted alternative thymidylate synthase
4 5 6 12 ------------------|--|--|||-----|----- 16 [F] COG1428 Deoxynucleoside kinases
8 12 15 30 ---||---|----|-|--|--|-||||-|-||----|- 30 [F] COG1435 Thymidine kinase
5 12 14 15 ||||-||||||----------|-|----|---|----- 17 [F] COG1437 Adenylate cyclase, class 2 (thermophilic)
5 7 9 17 ----||---|-|------------|--||--|-|---- 24 [F] COG1457 Purine-cytosine permease and related proteins
4 10 12 14 |||-|||||||---||---------------------- 14 [F] COG1618 Predicted nucleotide kinase
4 6 7 20 ------------------|---|-|||-|-------|- 22 [F] COG1780 Protein involved in ribonucleotide reduction
5 13 16 24 |||||||||||----|-------|----|-|--|---- 24 [F] COG1781 Aspartate carbamoyltransferase, regulatory subunit
6 10 13 19 -----------||---|----|||-|-||-|-|--||- 24 [F] COG1816 Adenosine deaminase
9 18 21 31 ||||||||||----|||||---|-||--------|||- 31 [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component
6 10 11 13 --|--------||---|--|-|-----||---|-||-- 15 [F] COG1864 DNA/RNA endonuclease G, NUC1
4 12 14 16 ||||||||||||||------------------------ 16 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)
4 7 10 16 ---------||||-----------|--||---|--||- 25 [FH] COG1953 Cytosine/uracil/thiamine/allantoin permeases
7 11 14 23 ---------|-||---|-|---|-|--||--||-|||- 47 [F] COG1957 Inosine-uridine nucleoside N-ribohydrolase
3 5 8 16 ----------------|-------||--|-||--||-- 29 [F] COG1972 Nucleoside permease
3 7 9 11 ||--||-||||-------------------------|- 12 [F] COG2019 Archaeal adenylate kinase
6 9 11 19 ----------------||||--||||-|---||----- 19 [F] COG2065 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase
8 15 16 23 --|-||||---||--|--||-|-||||---|------- 25 [F] COG2131 Deoxycytidylate deaminase
3 5 10 20 ----------------------|-||-||-|-|--||| 25 [F] COG2169 Adenosine deaminase
8 11 16 29 -----|------|--|--||--||||-||-||||--|- 69 [F] COG2233 Xanthine/uracil permeases
6 11 12 18 ----|------||--|---|---||||---|--|--|- 21 [F] COG2759 Formyltetrahydrofolate synthetase
6 6 10 16 ---|----|||----------||--|--|-||------ 20 [F] COG2820 Uridine phosphorylase
1 1 4 9 ---------------------------||-||------ 9 [F] COG3072 Adenylate cyclase
2 4 5 11 -----------||--------------||-------|- 13 [F] COG3194 Ureidoglycolate hydrolase
1 4 4 4 ||-|---|------------------------------ 4 [F] COG3363 Archaeal IMP cyclohydrolase
5 8 9 10 --|---------|--------|---|||----|--||- 11 [F] COG3613 Nucleoside 2-deoxyribosyltransferase
2 4 4 4 -|-----|---||------------------------- 4 [F] COG4088 Predicted nucleotide kinase
2 5 5 5 -----------||--------------|----|---|- 5 [F] COG4266 Allantoicase
3 4 4 4 ------------------|---|------|--|----- 4 [F] COG4290 Guanyl-specific ribonuclease Sa
2 3 3 3 -----------|----||-------------------- 4 [F] COG4360 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II)
2 2 4 4 ----------------|----------||-|------- 4 [FJ] COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA
2 4 4 7 ------------------|--------|----|---|- 8 [F] COG4630 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A
2 4 5 8 ------------------|--------|----|--||- 9 [F] COG4631 Xanthine dehydrogenase, molybdopterin-binding subunit B
3 4 4 5 --|-|---|------|---------------------- 5 [F] COG4741 Predicted secreted endonuclease distantly related to archaeal Holliday junction resolvase
2 3 4 4 ------------|-------------------|--||- 5 [F] COG5042 Purine nucleoside permease