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11 22 30 48 |||||-|||||-|-|-|||||-|||--||||||||||-  61 [H]  COG0001 Glutamate-1-semialdehyde aminotransferase
10 21 30 46 |||--||||||||-|||||---||||-||||||||||-  48 [E]  COG0002 Acetylglutamate semialdehyde dehydrogenase
 8 15 16 20 ||-|||-||-|||-|-||-|--|-|-------------  34 [P]  COG0003 Oxyanion-translocating ATPase
10 21 26 40 |||-|-||-|-||-|||||---||||||||--||-||-  58 [P]  COG0004 Ammonia permease
 9 20 25 36 |||||||||||||-||||----||||-|||------|-  46 [F]  COG0005 Purine nucleoside phosphorylase
14 28 38 65 |||||||||||||||||||||||||||||||||||||| 131 [E]  COG0006 Xaa-Pro aminopeptidase
10 21 28 44 |||||-|||||||-|-||||--|||--||||-||-||-  67 [H]  COG0007 Uroporphyrinogen-III methylase
14 28 38 66 |||||||||||||||||||||||||||||||||||||| 111 [J]  COG0008 Glutamyl- and glutaminyl-tRNA synthetases
14 27 37 63 ||||||||||||||||||||||||||||||||||-|||  82 [J]  COG0009 Putative translation factor (SUA5)
 8 21 29 41 |||||||||||||---||||---|||-||||||||-|-  78 [E]  COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family
 8 15 16 22 ||-||||||--|--||-|----||||------------  25 [S]  COG0011 Uncharacterized conserved protein
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0012 Predicted GTPase, probable translation factor
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  66 [J]  COG0013 Alanyl-tRNA synthetase
10 16 23 39 --|--------||-|||||--|||||-||||||||||-  41 [E]  COG0014 Gamma-glutamyl phosphate reductase
11 24 32 54 ||||||||||-||-||||||--||||-||||||||||-  67 [F]  COG0015 Adenylosuccinate lyase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0016 Phenylalanyl-tRNA synthetase alpha subunit
10 21 27 44 ||||||||||||||--||||-|-||||-||||------  63 [J]  COG0017 Aspartyl/asparaginyl-tRNA synthetases
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0018 Arginyl-tRNA synthetase
 9 20 27 47 |||-|-||---||-|||||---||||-||||||||||-  76 [E]  COG0019 Diaminopimelate decarboxylase
14 27 37 62 ||||||||||||||||||||||||||-|||||||||||  76 [I]  COG0020 Undecaprenyl pyrophosphate synthase
11 18 25 49 -----------||||||||-|||||||||||||||||-  62 [G]  COG0021 Transketolase
10 16 21 35 ---||---||||||--|||-|-|-||||----|--|||  56 [C]  COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
 5 14 19 26 |||||||||||||---||---------||-||------  29 [J]  COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins
14 27 37 65 |||||||||||||||||||||||-||||||||||||||  82 [J]  COG0024 Methionine aminopeptidase
 8 18 23 34 ||||||||---|||--|||---|-||-|||||----|-  56 [P]  COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
10 15 23 41 ---||---||-||-|||||---|-||-|||||||-||-  41 [F]  COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)
 6  8 11 18 -|---|---|------||----|-|--||-||------  18 [F]  COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)
10 22 31 49 |||-|||||||||-|||||---||||-||||||||||- 146 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
 8 13 18 30 ---|-|---|----|-||-|--|||--||||-||-||-  32 [H]  COG0029 Aspartate oxidase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  75 [J]  COG0030 Dimethyladenosine transferase (rRNA methylation)
11 20 29 50 --||||--|||||-||||||--||||-||||||||||- 103 [E]  COG0031 Cysteine synthase
 5  7  9 18 -----------||----||---|-----|-|----||-  19 [G]  COG0033 Phosphoglucomutase
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  53 [F]  COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase
12 21 29 48 |--|-|--|||||-||||||-||||||||-|||||||-  52 [F]  COG0035 Uracil phosphoribosyltransferase
13 21 28 53 -|--|------||||||||||||||||||||||||||-  65 [G]  COG0036 Pentose-5-phosphate-3-epimerase
14 28 38 66 |||||||||||||||||||||||||||||||||||||| 120 [D]  COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
10 21 27 41 -|||||||-||||-|-||||--||||--|-||||-||-  68 [P]  COG0038 Chloride channel protein EriC
13 26 34 55 |||||-|||||||-|||||||||||||-|||||-||||  71 [C]  COG0039 Malate/lactate dehydrogenases
10 21 28 44 ||||--||||-||-|||||---||||-|||||-||||-  45 [E]  COG0040 ATP phosphoribosyltransferase
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  51 [F]  COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
13 24 32 54 ||||--||---|||||||||||||||-|||||||||||  98 [J]  COG0042 tRNA-dihydrouridine synthase
 9 19 27 41 |||-||||||||--|-|||-|---|--||-||||||||  51 [H]  COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases
11 24 30 48 |||||||||||||-||||||--||||-|||--|-|||-  69 [F]  COG0044 Dihydroorotase and related cyclic amidohydrolases
10 20 29 46 ||-||-|||||||-|-|||-|-|-|--|||||||||||  50 [C]  COG0045 Succinyl-CoA synthetase, beta subunit
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  51 [F]  COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  51 [F]  COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0048 Ribosomal protein S12
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0049 Ribosomal protein S7
12 19 27 53 -------|---||-||||||||||||||||||||||||  73 [J]  COG0050 GTPases - translation elongation factors
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0051 Ribosomal protein S10
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0052 Ribosomal protein S2
12 24 32 47 ||||-||||||||-||||||-|||||-||-|||-||||  67 [P]  COG0053 Predicted Co/Zn/Cd cation transporters
12 23 32 51 ||||--|||||||-|||||||-||||-||||||||||-  55 [H]  COG0054 Riboflavin synthase beta-chain
 9 16 24 48 --|--------||-||||-|--||||||||||||||||  53 [C]  COG0055 F0F1-type ATP synthase, beta subunit
 9 16 24 48 --|--------||-||||-|--||||||||||||||||  53 [C]  COG0056 F0F1-type ATP synthase, alpha subunit
14 28 37 63 |||||||||||||||||||||||||||||||||||||-  93 [G]  COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
11 16 21 35 -||--|--||-|--|-|||||-||||-||-||----|-  43 [G]  COG0058 Glucan phosphorylase
10 20 28 47 |||--|||||-|--|||||---||||-||||||||||-  49 [EH] COG0059 Ketol-acid reductoisomerase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0060 Isoleucyl-tRNA synthetase
12 26 36 62 ||||||||||||||||||-|-|||||||||||||||||  74 [G]  COG0061 Predicted sugar kinase
10 22 28 42 |||||||||||||-|||||---||---||||-|-|||-  42 [S]  COG0062 Uncharacterized conserved protein
11 24 32 49 |||||||||||||||||||---||||-||||-|||||-  52 [G]  COG0063 Predicted sugar kinase
13 25 30 50 ||||--||-||||-||||||||||||||----||||||  52 [J]  COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)
10 22 30 47 ||||-|||||-||-|||||---||||-||||||||||-  56 [E]  COG0065 3-isopropylmalate dehydratase large subunit
10 21 29 47 |||--|||||-||-|||||---||||-||||||||||-  57 [E]  COG0066 3-isopropylmalate dehydratase small subunit
10 20 26 39 |||---||||-||-|||||---||||-||||-|-|||-  45 [E]  COG0067 Glutamate synthase domain 1
 5 12 12 18 |||--|||------|-||-----|----|-----|---  20 [O]  COG0068 Hydrogenase maturation factor
10 20 26 39 |||---||||-||-|||||---||||-||||-|-|||-  52 [E]  COG0069 Glutamate synthase domain 2
10 20 26 39 |||---||||-||-|||||---||||-||||-|-|||-  46 [E]  COG0070 Glutamate synthase domain 3
10 22 29 44 |||||||||||||-|||||---|||--||||-|--|||  91 [O]  COG0071 Molecular chaperone (small heat shock protein)
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0072 Phenylalanyl-tRNA synthetase beta subunit
14 28 38 66 |||||||||||||||||||||||||||||||||||||| 120 [R]  COG0073 EMAP domain
10 20 29 46 ||-||-|||||||-|-|||-|-|-|--|||||||||||  57 [C]  COG0074 Succinyl-CoA synthetase, alpha subunit
 9 20 26 33 ||||||||||||--|||||----|||-||-|---|||-  43 [E]  COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase
 7 15 18 26 ||||-|||--||----||----|-||--|-||----|-  46 [E]  COG0076 Glutamate decarboxylase and related PLP-dependent proteins
10 22 30 47 |||||-||||-||-|||||---||||-||||||||||-  47 [E]  COG0077 Prephenate dehydratase
11 25 34 54 |||||||||||||-|||||--||||||||||||||||-  65 [E]  COG0078 Ornithine carbamoyltransferase
11 24 33 51 |||||||||||||-||||||--||||-||||||||||-  96 [E]  COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0080 Ribosomal protein L11
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0081 Ribosomal protein L1
12 25 34 56 |||||||||||||-|||||||-||||-||||||||||-  56 [E]  COG0082 Chorismate synthase
10 18 24 41 -|-|||-||||||-|||||---||||--||||--|---  41 [E]  COG0083 Homoserine kinase
14 25 35 62 |||--|-|||||||||||||||||||||||||||||||  90 [L]  COG0084 Mg-dependent DNase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  79 [K]  COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  92 [K]  COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0087 Ribosomal protein L3
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0088 Ribosomal protein L4
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0089 Ribosomal protein L23
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0090 Ribosomal protein L2
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0091 Ribosomal protein L22
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  66 [J]  COG0092 Ribosomal protein S3
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0093 Ribosomal protein L14
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0094 Ribosomal protein L5
10 15 19 33 ---|||---||||-||||--|-|-|||||-|-------  61 [H]  COG0095 Lipoate-protein ligase A
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0096 Ribosomal protein S8
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0097 Ribosomal protein L6P/L9E
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0098 Ribosomal protein S5
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0099 Ribosomal protein S13
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0100 Ribosomal protein S11
14 28 36 63 |||||||||--|||||||||||||||||||||||||||  69 [J]  COG0101 Pseudouridylate synthase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0102 Ribosomal protein L13
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0103 Ribosomal protein S9
11 24 32 54 ||||||||||-||-||||||--||||-||||||||||-  55 [F]  COG0104 Adenylosuccinate synthase
12 25 35 57 |||||||||||||||-|||-||||||-|||||||||||  57 [F]  COG0105 Nucleoside diphosphate kinase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  45 [E]  COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  47 [E]  COG0107 Imidazoleglycerol-phosphate synthase
12 23 32 51 ||||--|||||||-|||||||-||||-||||||||||-  57 [H]  COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase
 9 15 21 37 ---||-|-|||||-|-|||---|-|--|||--|--|||  41 [O]  COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor)
10 21 28 44 ||||-|-||--||--||||-|-||||-||-|||||||| 111 [R]  COG0110 Acetyltransferase (isoleucine patch superfamily)
10 23 31 49 |||||||||||||-|||||---||||-||||||-|||- 113 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
13 27 37 64 |||||||||||||||||||-||||||||||||||||||  79 [E]  COG0112 Glycine/serine hydroxymethyltransferase
11 23 32 51 |||||-|||||||-|-|||||-|||--|||||||||||  52 [H]  COG0113 Delta-aminolevulinic acid dehydratase
 9 14 23 42 --||----|||||----||-|-|-|--|||||||||||  43 [C]  COG0114 Fumarase
11 22 30 50 ||||--|||--||-||||||--||||-||||||||||| 112 [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
 7 12 19 32 -|---||||-|------|||---|||-|||||||----  32 [L]  COG0116 Predicted N6-adenine-specific DNA methylase
10 16 23 42 -----------||-|||||||-||||-||||||||||-  42 [H]  COG0117 Pyrimidine deaminase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  47 [E]  COG0118 Glutamine amidotransferase
10 22 30 47 |||-||||||-||-|||||---||||-||||||||||- 102 [E]  COG0119 Isopropylmalate/homocitrate/citramalate synthases
10 22 31 48 ||||||||||||||--|||-||-|||-|||||||-||-  49 [G]  COG0120 Ribose 5-phosphate isomerase
 6 12 17 28 ||--||--||-|----||----|----||-||||--|-  37 [R]  COG0121 Predicted glutamine amidotransferase
 9 18 22 32 |-||-||---||||---||---|||-|||||-|--||-  41 [L]  COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase
 9 19 24 31 ||||-||||||||||-|||-----|--|--|-||-||-  55 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0124 Histidyl-tRNA synthetase
14 27 37 65 |||||||||||||||||||||||-||||||||||||||  70 [F]  COG0125 Thymidylate kinase
14 28 37 64 |||||||||||||||||||||||||||||||||||||-  65 [G]  COG0126 3-phosphoglycerate kinase
14 27 36 57 ||||||||||||||||||||||||||-||||||||||-  59 [F]  COG0127 Xanthosine triphosphate pyrophosphatase
12 25 34 56 |||||||||||||-|||||||-||||-||||||||||-  58 [E]  COG0128 5-enolpyruvylshikimate-3-phosphate synthase
10 21 30 49 |||--||||||||-|||||---||||-||||||||||-  85 [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase
14 28 38 62 ||||||||||||||||||||||||||||||||||||||  67 [J]  COG0130 Pseudouridine synthase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  45 [E]  COG0131 Imidazoleglycerol-phosphate dehydratase
 9 14 20 36 -|---------|--|-||-||-|||--||||||||||-  46 [H]  COG0132 Dethiobiotin synthetase
11 23 30 49 ||||-|||---||-|||||||-||||-||||||||||-  50 [E]  COG0133 Tryptophan synthase beta chain
10 23 32 52 |||||||||||||-|||||---||||-||||||||||-  56 [E]  COG0134 Indole-3-glycerol phosphate synthase
11 24 33 50 |||||||||||||-|||||-|-||||-||||||||||-  50 [E]  COG0135 Phosphoribosylanthranilate isomerase
11 24 34 56 |||||||||||||-|||||-|-||||-|||||||||||  68 [E]  COG0136 Aspartate-semialdehyde dehydrogenase
10 22 30 47 |||||-||||-||-|||||---||||-||||||||||-  47 [E]  COG0137 Argininosuccinate synthase
10 19 26 44 --|||-|----||-||||||--||||-||||||||||-  46 [F]  COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  45 [E]  COG0139 Phosphoribosyl-AMP cyclohydrolase
10 20 28 44 ||||---|||-||-|||||---||||-||||||||||-  44 [E]  COG0140 Phosphoribosyl-ATP pyrophosphohydrolase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  50 [E]  COG0141 Histidinol dehydrogenase
14 27 37 62 ||||||||||||||||||||||||||-||||||||||| 120 [H]  COG0142 Geranylgeranyl pyrophosphate synthase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0143 Methionyl-tRNA synthetase
12 22 31 49 -|-|-|||||||||-||||||-||||-||||||||||-  96 [J]  COG0144 tRNA and rRNA cytosine-C5-methylases
 8 15 18 23 -||-|-|||||||-|-||----|-|---------|||-  49 [EQ] COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit
 7 13 16 20 -||-|--||||||-|-||----|-----------|||-  29 [EQ] COG0146 N-methylhydantoinase B/acetone carboxylase, alpha subunit
11 24 33 54 |||||||||||||-||||||--||||-||||||||||- 102 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I
14 28 37 64 |||||||||||||||||||||||||||||||||||||-  72 [G]  COG0148 Enolase
14 28 37 64 |||||||||||||||||||||||||||||||||||||-  69 [G]  COG0149 Triosephosphate isomerase
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  51 [F]  COG0150 Phosphoribosylaminoimidazole (AIR) synthetase
11 24 32 53 ||||||||||-||-||||||--||||-||||||||||-  53 [F]  COG0151 Phosphoribosylamine-glycine ligase
11 24 33 53 ||||||||||-||-||||||--||||-|||||||||||  56 [F]  COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
 9 11 14 23 -----|--|--||--|---|-|||||--|-||------  24 [G]  COG0153 Galactokinase
13 25 32 52 ||||--|||||||-|||||||||||||||---|||||| 113 [J]  COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases
 9 14 20 32 ------|-||-||-|-|||---|||--||||-||-||-  45 [P]  COG0155 Sulfite reductase, beta subunit (hemoprotein)
11 18 25 44 -|--||-----||||-|||||-|-|--|||||||||||  78 [H]  COG0156 7-keto-8-aminopelargonate synthetase and related enzymes
10 21 29 45 ||||-|||||-|--||||-|--||||-||||||||||-  50 [H]  COG0157 Nicotinate-nucleotide pyrophosphorylase
 4  9 14 23 ---|-------||---||---------||-|||||||-  23 [G]  COG0158 Fructose-1,6-bisphosphatase
11 24 33 53 |||||||||||||-|||||-|-||||-||||||||||-  54 [E]  COG0159 Tryptophan synthase alpha chain
 8 15 20 34 --||||--|||||---|-|---|||--||-|||---|-  69 [E]  COG0160 4-aminobutyrate aminotransferase and related aminotransferases
 9 14 20 37 -|---------||-|---|||-|||--||||||||||-  78 [H]  COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  74 [J]  COG0162 Tyrosyl-tRNA synthetase
 9 19 27 41 |||-||||||||--|-|||-|---|--||-||||||||  46 [H]  COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase
14 27 37 60 ||||||||||||||||||||||||||-|||||||||||  60 [L]  COG0164 Ribonuclease HII
10 22 30 47 |||||-||||-||-|||||---||||-||||||||||-  51 [E]  COG0165 Argininosuccinate lyase
14 23 32 57 -|-||---|||||||||||||||||||||||||||||-  60 [G]  COG0166 Glucose-6-phosphate isomerase
11 24 33 55 |||||||||||||-||||||--||||-||||||||||-  67 [F]  COG0167 Dihydroorotate dehydrogenase
11 23 27 43 ||||-|||--|||-||||||-|--|||||-||-||-|-  60 [P]  COG0168 Trk-type K+ transport systems, membrane components
12 25 34 56 |||||||||||||-|||||||-||||-||||||||||-  78 [E]  COG0169 Shikimate 5-dehydrogenase
 8 16 16 20 |||-|||||--||||-||---|---------------|  25 [I]  COG0170 Dolichol kinase
12 26 34 59 |||||||||||||-||||||-||||||||||-|||||-  65 [H]  COG0171 NAD synthase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0172 Seryl-tRNA synthetase
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0173 Aspartyl-tRNA synthetase
10 22 32 54 |||||||||||||-|||||---|-||-||||||||||| 101 [E]  COG0174 Glutamine synthetase
 9 19 26 39 -|||||-||||||---||||--|||--||||-||-||-  73 [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes
10 17 23 44 -|--|------||-|||||-|-||||-||-|||||||-  64 [G]  COG0176 Transaldolase
14 27 37 62 ||||||||||||||||||||||||||-|||||||||||  70 [L]  COG0177 Predicted EndoIII-related endonuclease
11 19 27 52 |-||----------||||||||||||||||||||||||  59 [L]  COG0178 Excinuclease ATPase subunit
 8 20 27 43 |||||||||||||---|||---|-|--||-|||||||-  78 [Q]  COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  72 [J]  COG0180 Tryptophanyl-tRNA synthetase
11 23 32 52 |||||-|||||||-|-|||||-|||--|||||||||||  52 [H]  COG0181 Porphobilinogen deaminase
 9 18 21 24 |||-|||||||||-||||-|----|--|-|------|-  24 [J]  COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
11 23 31 49 ||||||||||||||---|||-|||||-||-|||-|||| 189 [I]  COG0183 Acetyl-CoA acetyltransferase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0184 Ribosomal protein S15P/S13E
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0185 Ribosomal protein S19
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0186 Ribosomal protein S17
13 23 31 58 --|||-|----|||||||||||||||||||||||||||  94 [L]  COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
13 23 31 58 --|||-|----|||||||||||||||||||||||||||  96 [L]  COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
 6 14 22 34 -|||-||-|||-----|||-----|-||||||||-||-  55 [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)
13 22 31 57 --|||---||-||-||||||||||||||||||||||||  64 [H]  COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase
 9 16 22 45 -----------||-|||||--||||||||-|||||||-  71 [G]  COG0191 Fructose/tagatose bisphosphate aldolase
10 17 24 48 -----------||-||||||-||||||||||||||||-  51 [H]  COG0192 S-adenosylmethionine synthetase
11 18 26 52 -----------||-||||||||||||||||||||||||  53 [J]  COG0193 Peptidyl-tRNA hydrolase
11 18 26 51 -----------||||||||||-||||||||||||||||  53 [F]  COG0194 Guanylate kinase
12 25 35 63 |||||||||||---||||||||||||||||||||||||  71 [K]  COG0195 Transcription elongation factor
11 18 25 49 -----------||-|||||||||||||||||||||||-  51 [H]  COG0196 FAD synthase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0197 Ribosomal protein L16/L10E
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0198 Ribosomal protein L24
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  76 [J]  COG0199 Ribosomal protein S14
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0200 Ribosomal protein L15
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [U]  COG0201 Preprotein translocase subunit SecY
14 27 37 65 ||-|||||||||||||||||||||||||||||||||||  68 [K]  COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0203 Ribosomal protein L17
12 19 27 52 -----------||||||||||||||||||||||||||| 137 [I]  COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase
12 17 21 42 -----------||||||||||||||||-||||----|-  50 [G]  COG0205 6-phosphofructokinase
10 23 31 57 ||||||||------||||||-|||||||||||||||||  81 [D]  COG0206 Cell division GTPase
 8 17 24 44 |||---||---|||----||--||||||||||||-||-  47 [F]  COG0207 Thymidylate synthase
13 19 27 49 ---|-----|-||||--|||||||||||||||||||||  62 [F]  COG0208 Ribonucleotide reductase, beta subunit
14 25 35 61 |-|||||-||||||||-|||||||||||||||||||||  88 [F]  COG0209 Ribonucleotide reductase, alpha subunit
12 22 30 57 |-|||------||-|||||||||||||||||||||||| 123 [L]  COG0210 Superfamily I DNA and RNA helicases
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0211 Ribosomal protein L27
12 21 31 52 |--|---||||||-|-||||||||||||||||||||||  55 [H]  COG0212 5-formyltetrahydrofolate cyclo-ligase
 6 13 15 29 -||--||--------|--|---|||||-|-|-|---|-  30 [F]  COG0213 Thymidine phosphorylase
 9 18 21 30 |||||||||||||--|--||--||||-----|------  32 [H]  COG0214 Pyridoxine biosynthesis enzyme
14 25 35 63 --|||||-||||||||||||||||||||||||||||||  67 [J]  COG0215 Cysteinyl-tRNA synthetase
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0216 Protein chain release factor A
11 18 26 51 -----------||-||||||||||||||||||||||||  58 [S]  COG0217 Uncharacterized conserved protein
 7 17 25 47 -|||-|||---|--||---|---|||||||||||||||  47 [R]  COG0218 Predicted GTPase
 7 13 20 40 ----------------|||||-|||||||||||||||-  41 [J]  COG0219 Predicted rRNA methylase (SpoU class)
12 19 27 52 -----------|||||||||||||||||||||||||||  52 [R]  COG0220 Predicted S-adenosylmethionine-dependent methyltransferase
12 24 32 55 |-||||-|-||||||-|||||-|||-||||||||||||  59 [C]  COG0221 Inorganic pyrophosphatase
11 18 26 52 -----------||-||||||||||||||||||||||||  55 [J]  COG0222 Ribosomal protein L7/L12
11 18 26 52 -----------||-||||||||||||||||||||||||  64 [J]  COG0223 Methionyl-tRNA formyltransferase
 9 16 24 48 --|--------||-||||-|--||||||||||||||||  50 [C]  COG0224 F0F1-type ATP synthase, gamma subunit
10 19 26 48 |-||-----|-||---||||-||||||||||||||||-  62 [O]  COG0225 Peptide methionine sulfoxide reductase
10 22 30 48 ||||-||||||---|||||--||||||||||||-|||-  78 [P]  COG0226 ABC-type phosphate transport system, periplasmic component
11 18 26 50 -----------||-||||||||||||||||||||||||  53 [J]  COG0227 Ribosomal protein L28
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0228 Ribosomal protein S16
 9 18 25 45 |-||-------||---||||-||||||||||||||||-  53 [O]  COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase
10 17 25 50 -----------||-|||||-||||||||||||||||||  50 [J]  COG0230 Ribosomal protein L34
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  78 [J]  COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)
 5  7 12 24 -----------------||---|-|--||-|||--|||  28 [F]  COG0232 dGTP triphosphohydrolase
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0233 Ribosome recycling factor
12 19 27 51 --|--------||-||||||||||||||||||||||||  58 [O]  COG0234 Co-chaperonin GroES (HSP10)
10 23 31 47 |||||||||-|||-|||--|--|||||||||||-||||  87 [G]  COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
12 19 27 53 --|--------||-|||||||||||||||||||||||| 115 [IQ] COG0236 Acyl carrier protein
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  67 [H]  COG0237 Dephospho-CoA kinase
11 18 26 51 -----------||-||||||||||||||||||||||||  53 [J]  COG0238 Ribosomal protein S18
 9 19 26 43 -|||-|-|---||-|||||---||||-||||||||||-  60 [D]  COG0239 Integral membrane protein possibly involved in chromosome condensation
13 21 29 52 |-----|----|||||||||||||||||||||||||||  56 [C]  COG0240 Glycerol-3-phosphate dehydrogenase
 8 13 19 30 -|--|------|||---|-|--||---||||||||||-  39 [E]  COG0241 Histidinol phosphatase and related phosphatases
10 16 24 50 --------------||||||||||||||||||||||||  65 [J]  COG0242 N-formylmethionyl-tRNA deformylase
 8 18 24 39 ||-||||||||---|-|||---|-|--||-|||-|||- 149 [C]  COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0244 Ribosomal protein L10
10 16 22 41 --------------|||||||||||-|||||||||||-  41 [I]  COG0245 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
 5  9 14 26 -----------|---|------|||||||-|||--||-  54 [G]  COG0246 Mannitol-1-phosphate/altronate dehydrogenases
 9 19 26 42 |||||-|||||---|-||||--|-||-||-|||||-|- 115 [C]  COG0247 Fe-S oxidoreductase
11 16 23 38 --|------|-|--||||||--|||--|||||||||||  54 [FP] COG0248 Exopolyphosphatase
12 19 27 44 --|||------|||||||||||-|||-|||||||-|||  59 [L]  COG0249 Mismatch repair ATPase (MutS family)
13 26 36 64 |||||||||||-|-||||||||||||||||||||||||  72 [K]  COG0250 Transcription antiterminator
11 18 27 48 ---|-|--|||||-||||||--||||-||||||||||- 142 [J]  COG0251 Putative translation initiation inhibitor, yjgF family
 8 20 28 46 |||||||||||||-----||--||||-||||||||-|-  64 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D
 9 17 24 44 ||----||------||||-||-|||--|||||||||||  46 [E]  COG0253 Diaminopimelate epimerase
10 16 24 50 --------------||||||||||||||||||||||||  64 [J]  COG0254 Ribosomal protein L31
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0255 Ribosomal protein L29
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  67 [J]  COG0256 Ribosomal protein L18
10 17 25 50 -----------||-|||||-||||||||||||||||||  56 [J]  COG0257 Ribosomal protein L36
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  90 [L]  COG0258 5'-3' exonuclease (including N-terminal domain of PolI)
 5  9 15 25 -----------||---|||---|----|||||||-||-  28 [H]  COG0259 Pyridoxamine-phosphate oxidase
11 16 23 44 ----------|-|||-|||||-|-|-||||||||||||  61 [E]  COG0260 Leucyl aminopeptidase
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0261 Ribosomal protein L21
10 15 23 45 --|--------|||-|--|||-||||||||||||-|||  68 [H]  COG0262 Dihydrofolate reductase
10 16 23 39 --|--------||-|||||--|||||-||||||||||-  43 [E]  COG0263 Glutamate 5-kinase
11 17 25 51 ------------|-||||||||||||||||||||||||  51 [J]  COG0264 Translation elongation factor Ts
13 21 30 53 |-||----||-||-||||||||||||-||||||||||| 134 [O]  COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
 5  9 17 37 ----------------|||---|-||||||||||-|||  50 [L]  COG0266 Formamidopyrimidine-DNA glycosylase
11 18 26 51 -----------||-||||||||||||||||||||||||  63 [J]  COG0267 Ribosomal protein L33
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0268 Ribosomal protein S20
 4 11 16 24 |||--||||||------------||||-|-||------  30 [G]  COG0269 3-hexulose-6-phosphate synthase and related proteins
 7 16 24 34 ||---|-||||-|---||----|||||-|||||||||-  63 [L]  COG0270 Site-specific DNA methylase
 4  8 15 26 ---|-------||---||---------|||||||-|||  37 [T]  COG0271 Stress-induced morphogen (activity unknown)
10 16 24 50 --------------||||||||||||||||||||||||  57 [L]  COG0272 NAD-dependent DNA ligase (contains BRCT domain type II)
10 16 20 39 |--||---|-|---|||||--||||||-|-||----|-  44 [F]  COG0274 Deoxyribose-phosphate aldolase
10 16 24 50 --------------||||||||||||||||||||||||  50 [M]  COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis
 9 14 22 43 ----|------||-|-|||-|-|-||-|||||||||||  44 [H]  COG0276 Protoheme ferro-lyase (ferrochelatase)
10 19 27 43 --|||-|-|||||-|-||||--|||--||||||||||- 171 [C]  COG0277 FAD/FMN-containing dehydrogenases
 5  9 16 27 ---|-------|||--||---------|||||||-|||  31 [O]  COG0278 Glutaredoxin-related protein
 7 11 14 25 -|--|---------|--|-|--||---||-||-||-|-  34 [G]  COG0279 Phosphoheptose isomerase
 9 15 23 46 --||-----------|-|||-|||||||||||||||||  70 [C]  COG0280 Phosphotransacetylase
 9 19 29 47 --|||||-|||||--||||---||||-|||||||||||  69 [C]  COG0281 Malic enzyme
 9 15 20 43 --|------------|||||-||||||||-||-||-||  55 [C]  COG0282 Acetate kinase
11 16 24 47 -------------|||||||||||||||||||||-|||  48 [F]  COG0283 Cytidylate kinase
11 24 33 55 |||||||||||||-||||||--||||-||||||||||-  56 [F]  COG0284 Orotidine-5'-phosphate decarboxylase
11 18 26 48 ---||------||-||||||-|||||-|||||||||||  54 [H]  COG0285 Folylpolyglutamate synthase
 5 14 22 36 ||||-||---------|-----|-||||||||||||||  68 [V]  COG0286 Type I restriction-modification system methyltransferase subunit
10 22 31 50 |||||-|||||||-|||||---||||-||||||||||-  51 [E]  COG0287 Prephenate dehydrogenase
 8 15 23 39 |--|----||-||---|||---||||-||||||||||-  57 [P]  COG0288 Carbonic anhydrase
 8 17 25 45 |||---||------||||--|-||||-|||||||||||  46 [E]  COG0289 Dihydrodipicolinate reductase
10 16 24 50 --------------||||||||||||||||||||||||  51 [J]  COG0290 Translation initiation factor 3 (IF-3)
11 17 25 51 -----------|--||||||||||||||||||||||||  51 [J]  COG0291 Ribosomal protein L35
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0292 Ribosomal protein L20
 5 14 21 34 |||||-||---|||-------|-----|||||||-|||  41 [J]  COG0293 23S rRNA methylase
12 25 35 57 |||||||||||||-|||||||-||||-|||||||||||  69 [H]  COG0294 Dihydropteroate synthase and related enzymes
 9 13 18 35 ---|----|-|||--|--|--||||||-|-||---||-  37 [F]  COG0295 Cytidine deaminase
11 14 18 28 --|------|-|--|-|||||-|-||-||-|||---|-  39 [G]  COG0296 1,4-alpha-glucan branching enzyme
11 16 21 32 -|---|--||--|-|||||||--|||-||-|||---|-  38 [G]  COG0297 Glycogen synthase
 4 11 12 18 |||--|||--------||-----|----|--|--|---  22 [O]  COG0298 Hydrogenase maturation factor
11 19 26 44 --|||---|--||-||||||--||||-||||||||||-  45 [F]  COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN
 9 14 17 27 --|--|---|-|||--|--|--||||-|---||--||-  40 [R]  COG0300 Short-chain dehydrogenases of various substrate specificities
 6 15 21 36 |||||||||||----|-----|-||||||-||------  39 [H]  COG0301 Thiamine biosynthesis ATP pyrophosphatase
 9 15 23 41 --------||-||-|-||||--||||-||||||-||||  44 [H]  COG0302 GTP cyclohydrolase I
 8 20 26 44 |||||||||||---|-|||---|||--||-|||-|||-  70 [H]  COG0303 Molybdopterin biosynthesis enzyme
10 16 24 46 -----------||-|||||||-||||-||||||||||| 105 [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase
10 16 24 50 --------------||||||||||||||||||||||||  63 [L]  COG0305 Replicative DNA helicase
10 21 26 46 ||||||||||-|---||-|-|-|||--||-|||||-|-  71 [P]  COG0306 Phosphate/sulphate permeases
11 17 24 43 ---|-------||-|||||||-||||-||||||||||-  43 [H]  COG0307 Riboflavin synthase alpha chain
 9 14 21 36 --|-|---||-|||--|||---|--|-|||||||-||-  51 [E]  COG0308 Aminopeptidase N
 6 15 17 24 |||||||||||---|-||-----|----|-----|---  28 [O]  COG0309 Hydrogenase maturation factor
 4 12 13 13 ||||--||--------||-----||---|--|----|-  24 [P]  COG0310 ABC-type Co2+ transport system, permease component
 8 17 20 29 |||||||||||||--|--|---||||-----|------  31 [H]  COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis
 9 19 27 40 |||-|||||||---|||||---|||--|||||||-||- 102 [R]  COG0312 Predicted Zn-dependent proteases and their inactivated homologs
10 16 24 50 --------------||||||||||||||||||||||||  53 [R]  COG0313 Predicted methyltransferases
 8 18 24 41 |||||||-|||---|-|||---|-|--||-|||-|||-  45 [H]  COG0314 Molybdopterin converting factor, large subunit
 8 20 26 43 |||||||||||---|-|||---|||--||-|||-|||-  47 [H]  COG0315 Molybdenum cofactor biosynthesis enzyme
 8 12 19 35 --|--------||-|-|||---|-|--|||||||-|||  80 [S]  COG0316 Uncharacterized conserved protein
 9 15 23 44 --------------||||||-|||||||||||||||||  67 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases
 9 18 28 47 |-|||-|-|||||---|||-|-|-||-||||||||||| 257 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II
10 16 24 50 --------------||||||||||||||||||||||||  50 [R]  COG0319 Predicted metal-dependent hydrolase
10 14 23 40 ---|----|||||-|-|||-|-|-|--|||||||-|||  43 [H]  COG0320 Lipoate synthase
 6 10 17 31 --------|--||---|||---|----|||||||-|||  31 [H]  COG0321 Lipoate-protein ligase B
11 19 27 52 |-||----------||||||||||||||||||||||||  63 [L]  COG0322 Nuclease subunit of the excinuclease complex
12 18 26 44 --||-------|||||||||||-|||-|||||||-|||  49 [L]  COG0323 DNA mismatch repair enzyme (predicted ATPase)
11 17 25 48 -----------||-||||||||||||-|||||||||||  52 [J]  COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase
10 16 23 43 --|--------||-||||||--||||-||||||||||-  44 [R]  COG0325 Predicted enzyme with a TIM-barrel fold
 8 14 19 35 -----------|||--||-|-||||--||||||-|-||  37 [O]  COG0326 Molecular chaperone, HSP90 family
11 22 27 47 ||||-|||---|||--|-|||||||||||-|||||---  56 [S]  COG0327 Uncharacterized conserved protein
 9 14 21 39 ---|----|--||---|||--||-|--|||||||||||  44 [L]  COG0328 Ribonuclease HI
10 22 32 56 |||||||||||---||||-||-||||-||||||||||| 114 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase
12 26 36 57 |||||||||||||-||||||-||||||||||||||||| 130 [O]  COG0330 Membrane protease subunits, stomatin/prohibitin homologs
10 16 24 45 -----------||-|||||||-||||-|||||||||||  65 [I]  COG0331 (acyl-carrier-protein) S-malonyltransferase
 8 13 21 40 --------------|-|||||-||||-|||||||||||  63 [I]  COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III
10 17 25 48 -----------||-||||||||-|||||||||||||||  49 [J]  COG0333 Ribosomal protein L32
11 21 28 42 --|||||-|||||--||||||-||||-||--||||||-  66 [E]  COG0334 Glutamate dehydrogenase/leucine dehydrogenase
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0335 Ribosomal protein L19
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0336 tRNA-(guanine-N1)-methyltransferase
11 18 27 49 ----||--|||||--||||||-||||-||||||||||-  50 [E]  COG0337 3-dehydroquinate synthetase
 6 13 16 24 -|--||----------||-|-|-||---||||-||--|  29 [L]  COG0338 Site-specific DNA methylase
 5  9 15 24 -----------||---|||---|----|||||||-||-  30 [E]  COG0339 Zn-dependent oligopeptidases
13 24 32 54 ||||-||--|-||-||||||||||||-|||||||||||  58 [H]  COG0340 Biotin-(acetyl-CoA carboxylase) ligase
11 22 29 50 ||||-|-|------|||||||||||-||||||||||||  52 [U]  COG0341 Preprotein translocase subunit SecF
11 22 29 50 ||||-|-|------|||||||||||-||||||||||||  55 [U]  COG0342 Preprotein translocase subunit SecD
14 26 36 57 |||||||||||-||||||||||||||-|||||||||||  61 [J]  COG0343 Queuine/archaeosine tRNA-ribosyltransferase
 7 13 19 38 --------------||||||---||||||-|||||||-  41 [S]  COG0344 Predicted membrane protein
11 19 28 48 |-|-|---|||||-|||||--|||||-||||||||||-  56 [E]  COG0345 Pyrroline-5-carboxylate reductase
 9 19 27 45 |-||-||--||||---||||--||||-||||||||||- 252 [E]  COG0346 Lactoylglutathione lyase and related lyases
 8 16 23 35 |||---||------|||||---||||-|||||||-||-  67 [E]  COG0347 Nitrogen regulatory protein PII
 5 13 18 29 -||-|-||-|------||-----|---||-|||||||-  43 [C]  COG0348 Polyferredoxin
 5  7 13 25 -----------|----||----||---|||||---|||  33 [J]  COG0349 Ribonuclease D
12 24 34 55 ||||||||||||--|||--|||||||||||||||||||  83 [L]  COG0350 Methylated DNA-protein cysteine methyltransferase
12 24 33 54 |||||||||||||-|||-||-|||||-||||||||||-  66 [H]  COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
 9 18 25 45 --|-|||----||-|-||||--||||-||||||||||-  60 [H]  COG0352 Thiamine monophosphate synthase
 9 15 23 45 --------------|-||||||||||||||||||||||  45 [L]  COG0353 Recombinational DNA repair protein (RecF pathway)
 6 10 17 31 -----------||-|-|||---|----|||||||-|||  31 [R]  COG0354 Predicted aminomethyltransferase related to GcvT
 9 16 24 48 --|--------||-||||-|--||||||||||||||||  50 [C]  COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit)
 9 15 23 47 --|--------|--||||-|--||||||||||||||||  47 [C]  COG0356 F0F1-type ATP synthase, subunit a
 9 15 23 47 --------------||||||-|||||||||||||||||  47 [M]  COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division
12 25 35 63 |||||||||||---||||||||||||||||||||||||  70 [L]  COG0358 DNA primase (bacterial type)
11 17 25 51 ------------|-||||||||||||||||||||||||  51 [J]  COG0359 Ribosomal protein L9
11 18 26 51 -----------||-||||||||||||||||||||||||  51 [J]  COG0360 Ribosomal protein S6
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0361 Translation initiation factor 1 (IF-1)
 9 13 16 34 -----------|||-|||--|||-||--|-||-|--|-  36 [G]  COG0362 6-phosphogluconate dehydrogenase
10 17 24 44 -----------|||-|||-||||||||||||||||||-  61 [G]  COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase
11 16 23 41 -----------||||||||-|||-||-||||||||||-  48 [G]  COG0364 Glucose-6-phosphate 1-dehydrogenase
10 19 27 40 |-|||-|-|||||||-|||---|-||-||||||-|||- 119 [I]  COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases
 9 16 20 34 --|-|---|--||--||||---|||||||-|-|--||- 137 [G]  COG0366 Glycosidases
 7 17 22 34 |||||||||-||||--------||||-||||-----|-  52 [E]  COG0367 Asparagine synthase (glutamine-hydrolyzing)
 8 19 23 34 |||||||||||-----||||--|||--||-|-|---|-  35 [H]  COG0368 Cobalamin-5-phosphate synthase
 6 10 14 24 -----------|||--||--|---|--||||--|-||-  34 [P]  COG0369 Sulfite reductase, alpha subunit (flavoprotein)
 8 18 22 30 |||--||||-----|||||----|||-||||-|-||--  37 [P]  COG0370 Fe2+ transport system protein B
 7 17 20 30 |||||||||||-|--|||-----|||--|-------|-  37 [C]  COG0371 Glycerol dehydrogenase and related enzymes
10 19 29 47 |-|||-|-|||||-|||||---|-||-|||||||||||  80 [C]  COG0372 Citrate synthase
10 20 27 42 |||||-|||||---|-|||||-|||--||||||||---  42 [H]  COG0373 Glutamyl-tRNA reductase
 5  8  8 13 --|---||------|-|------|----|-----|---  21 [C]  COG0374 Ni,Fe-hydrogenase I large subunit
 5 12 12 18 |||--|||------|-|||---------|-----|---  24 [R]  COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)
 6 10 13 20 --||--|----|-----|----|-|---|||-|--||-  21 [P]  COG0376 Catalase (peroxidase I)
 8 16 23 38 --|||||-|||---|||||---|----|||--||||||  39 [C]  COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases
 9 18 20 32 |||---||----|-|-||||--|-|-|||--||-|-|-  47 [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase
 9 20 26 40 ||||-|||||----||||-|--|||--||||-|||||-  42 [H]  COG0379 Quinolinate synthase
 7 11 11 19 |---|---|--|||---|----|-----|---|---|-  30 [G]  COG0380 Trehalose-6-phosphate synthase
 6 14 19 29 ||-|-|---------||||----|||-||-|||||--|  36 [M]  COG0381 UDP-N-acetylglucosamine 2-epimerase
10 23 32 49 |||||||||||||-|-|||-|-|||--|||||||||||  77 [H]  COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases
 8 11 12 16 ----||---|-||--|||----|-||--|---------  22 [G]  COG0383 Alpha-mannosidase
 8 14 18 28 --||-------||---||||--|||--||-|||--||-  43 [R]  COG0384 Predicted epimerase, PhzC/PhzF homolog
 7 10 13 24 --|--------|--|-||----|-|--||---||-||-  36 [R]  COG0385 Predicted Na+-dependent transporter
 7 12 16 26 -----------|||---|-|--||||||||--||-|--  36 [O]  COG0386 Glutathione peroxidase
 6  9  9 18 -----------||---|||---|-|---|-------|-  21 [P]  COG0387 Ca2+/H+ antiporter
11 22 30 48 |-|||||-|||||-|||||--|||||-||||-|||||- 126 [R]  COG0388 Predicted amidohydrolase
 8 15 21 39 --||-----|-||---||-|--|||||||-||||-||-  76 [L]  COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair
 7 10 10 15 -||-----------||||----|-|---|---|-----  15 [R]  COG0390 ABC-type uncharacterized transport system, permease component
 9 16 19 31 ||||--||---|--|||||---||||--|-||------  34 [S]  COG0391 Uncharacterized conserved protein
 7 18 20 35 ||||-|||------||||----|||-||||--|---|-  61 [S]  COG0392 Predicted integral membrane protein
 7 15 18 26 |||||||--|-----|||----|-||--|-||---|--  29 [S]  COG0393 Uncharacterized conserved protein
 8 17 24 38 |-||--|----||-|-|||---||||-||||||||||-  70 [T]  COG0394 Protein-tyrosine-phosphatase
 9 16 23 41 ---|||--|||----||||--||||||||||||---|- 207 [G]  COG0395 ABC-type sugar transport system, permease component
10 20 25 43 |||||||||||----||||-||||||--||-----||-  46 [O]  COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
 5  9 13 17 -----------||---||----|-|--||||-|--||-  18 [S]  COG0397 Uncharacterized conserved protein
 6 11 14 23 --||-------||---||----||||--|-|----||-  38 [S]  COG0398 Uncharacterized conserved protein
 9 17 23 34 ||---|-||-----||||---|||||-||-|||||||-  68 [M]  COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis
 6  9 13 23 -----------||---|||-|---||-|||------||  30 [R]  COG0400 Predicted esterase
 3  6  7 10 -----------||---||---------||-------|-  15 [S]  COG0401 Uncharacterized homolog of Blt101
10 23 30 42 |||||||||||||-|||||---||||-|||-||-|||-  96 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
10 16 21 35 ---|||---||||-|||||---|-|--|||--||-||-  36 [E]  COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain
10 16 21 36 ---|||---||||-|||||---|-|--|||--||-||-  79 [E]  COG0404 Glycine cleavage system T protein (aminomethyltransferase)
10 15 22 34 ----|---||||||--||||--|-|--||||-|||||-  48 [E]  COG0405 Gamma-glutamyltransferase
11 17 23 39 --|-|----|-||-||||||--||||-||||||--||- 132 [G]  COG0406 Fructose-2,6-bisphosphatase
 9 15 22 41 --|-|------||-|-|||-|-|-|--|||||||||||  54 [H]  COG0407 Uroporphyrinogen-III decarboxylase
 3  7 12 20 -----------||---||---------||||-|--|||  21 [H]  COG0408 Coproporphyrinogen III oxidase
 5 12 12 18 |||--|||------|-||-----|----|-----|---  19 [O]  COG0409 Hydrogenase maturation factor
 9 14 18 25 -|----|-|||----|||||--|-||-||---|-|-|-  72 [E]  COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
 8 13 16 23 -|----|-|||----|||||-----|-||---|-|-|-  60 [E]  COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
 8 13 15 23 --|-|----|-||-|-||----|-|--||---|--||-  50 [Q]  COG0412 Dienelactone hydrolase and related enzymes
10 17 24 42 ---|-|--|||||-|||||---|||--||||-|||||-  46 [H]  COG0413 Ketopantoate hydroxymethyltransferase
 8 14 19 36 -----------||-|||||---|||--||||-|||||-  37 [H]  COG0414 Panthothenate synthetase
 7 12 16 23 |-||-----|-|----||----|-||-||-|--|-||-  28 [L]  COG0415 Deoxyribodipyrimidine photolyase
 8 14 20 39 --------------|||||||--||||||-|||||||-  39 [I]  COG0416 Fatty acid/phospholipid biosynthesis enzyme
 6 14 18 24 ||||||||||||||--|----------||-|-------  47 [L]  COG0417 DNA polymerase elongation subunit (family B)
 3  7 10 19 -----------||----|---------||-|-|||-|-  19 [F]  COG0418 Dihydroorotase
12 22 27 36 ||||||||||||||||||||-|-|||-||-|-------  41 [L]  COG0419 ATPase involved in DNA repair
13 24 29 42 ||||||||||||||||||||-|||||-||-|-----|-  47 [L]  COG0420 DNA repair exonuclease
 9 18 24 34 -|--|||||||||-||--|---||||-|||--|||-|-  41 [E]  COG0421 Spermidine synthase
10 21 27 38 ||||-|||||----||||||--|||--||||-|||||-  42 [H]  COG0422 Thiamine biosynthesis protein ThiC
 8 18 20 29 ||||||||||||||----|--||||-|-----------  30 [J]  COG0423 Glycyl-tRNA synthetase (class II)
11 18 25 42 --|--|-----||-|||||||-|||--|||||||||||  57 [D]  COG0424 Nucleotide-binding protein implicated in inhibition of septum formation
 8 18 24 36 |||||-||||----||||-|----|--||-|||||||-  72 [O]  COG0425 Predicted redox protein, regulator of disulfide bond formation
 7 13 14 18 |||--||-------||||-|---|---||---|-----  39 [C]  COG0426 Uncharacterized flavoproteins
 6  9 11 16 ---|--|----||----|-|--|----||------||-  19 [C]  COG0427 Acetyl-CoA hydrolase
12 20 24 31 ||||-|--|||||||||-|--||-|--||---|||-|-  38 [P]  COG0428 Predicted divalent heavy-metal cations transporter
 4  6  9 14 -----------|-|--||---------||-|-||----  16 [R]  COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold
 7 15 18 22 ||||-||||||||||-|----------||---|-----  22 [A]  COG0430 RNA 3'-terminal phosphate cyclase
 7 12 18 33 ---|-------||---|||---|-|||||-||||-||-  59 [R]  COG0431 Predicted flavoprotein
10 18 22 29 |||--||||||-|-|||||---|||--||-|-----|-  36 [S]  COG0432 Uncharacterized conserved protein
 9 19 25 34 |||||||||||---|||||---|-||-||--||--||-  71 [R]  COG0433 Predicted ATPase
 4 10 11 14 -|-|-||||-|-----||----------|-------|-  14 [R]  COG0434 Predicted TIM-barrel enzyme
 5  8 10 16 ---|-------||---||----|----||-|-----|-  18 [O]  COG0435 Predicted glutathione S-transferase
13 26 36 59 |||||||||||||-||||||||||||-||||||||||| 193 [E]  COG0436 Aspartate/tyrosine/aromatic aminotransferase
 4 10 15 21 --||-||-|||---|------------||-|||-|-|-  73 [C]  COG0437 Fe-S-cluster-containing hydrogenase components 1
13 26 36 58 ||||||||||||||||||||-|||||-||||||||||| 488 [M]  COG0438 Glycosyltransferase
11 20 27 45 |||---|--|-||-|-|||-||||||-||||||||||-  71 [I]  COG0439 Biotin carboxylase
10 21 27 45 |||--|||--|||-|||||---||||-||-|||||||-  50 [E]  COG0440 Acetolactate synthase, small (regulatory) subunit
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  75 [J]  COG0441 Threonyl-tRNA synthetase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0442 Prolyl-tRNA synthetase
13 23 31 58 |-|||------||||||||||||||||||||||||||| 134 [O]  COG0443 Molecular chaperone
11 20 26 47 --|||||-|||---||--|||||||||||-|||-|-|- 163 [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
10 17 25 48 -----------||-||||||||-|||||||||||||||  50 [D]  COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division
12 25 32 50 |||||||||||||-||||||-||||||||-|||--||- 171 [R]  COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases
 5  7 10 20 ---|--|---------||----|-||--|-||------  20 [H]  COG0447 Dihydroxynaphthoic acid synthase
 8 11 14 27 ---------------||||||-||||--|-||----|-  36 [G]  COG0448 ADP-glucose pyrophosphorylase
14 26 35 58 ||||||-|||||||||||||||||||-||||||||||-  71 [M]  COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
14 24 33 53 |||-|||-|||||||||||||||-||-||||||-||||  72 [O]  COG0450 Peroxiredoxin
12 25 33 53 ||||||||||-||-||||||-|||||-||||||||||- 289 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases
12 25 34 55 |||||||||||||-||||||-|||||-||||||||||-  66 [H]  COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase
13 26 36 58 |||||||-|||||||||||||-|||||||||||||||| 542 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
 8 16 17 24 ||-|-|||------|||----||||--|--|-|-|---  46 [D]  COG0455 ATPases involved in chromosome partitioning
12 26 35 54 ||||||||||||||||||||--|||||||||||||||- 112 [R]  COG0456 Acetyltransferases
13 25 33 53 |||||||--|-|||||||||||-|||-||||||||||| 510 [R]  COG0457 FOG: TPR repeat
11 23 31 51 |||||-||||-||-||||||--||||-||||||||||-  66 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
14 28 38 64 |||||||||||||||||||||||||||||||||||||| 122 [O]  COG0459 Chaperonin GroEL (HSP60 family)
10 23 32 53 |||||||||||||-|||||---||||-||||||||||-  62 [E]  COG0460 Homoserine dehydrogenase
12 25 34 56 |||||||||||||-|||||||-||||-||||||||||-  59 [F]  COG0461 Orotate phosphoribosyltransferase
12 26 36 62 |||||||||||||-||||||-|||||||||||||||||  76 [FE] COG0462 Phosphoribosylpyrophosphate synthetase
13 27 37 62 ||||||||||||||||||||-||||||||||||||||| 434 [M]  COG0463 Glycosyltransferases involved in cell wall biogenesis
 9 21 23 31 ||||||||||||||--|||---|-|--|----|-|-|- 107 [O]  COG0464 ATPases of the AAA+ class
11 18 26 52 -----------||-||||||||||||||||||||||||  74 [O]  COG0465 ATP-dependent Zn proteases
10 16 23 42 --|--------||-||--||||-||-||||||||||||  46 [O]  COG0466 ATP-dependent Lon protease, bacterial type
 7 15 17 21 ||||||||||||--||||------------------|-  70 [T]  COG0467 RecA-superfamily ATPases implicated in signal transduction
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  87 [L]  COG0468 RecA/RadA recombinase
13 24 33 57 -|||||--||||||-||||||||||||||||||||||-  71 [G]  COG0469 Pyruvate kinase
14 27 37 64 |||||||||||||||||||||||-|||||||||||||| 108 [L]  COG0470 ATPase involved in DNA replication
10 19 25 41 ||-|-|-||--||-|--||-|-||||-||||||||-|-  77 [P]  COG0471 Di- and tricarboxylate transporters
13 22 30 54 ||---|-|||-||-||||||||||||-||||||||-||  91 [M]  COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
10 21 30 48 |||--|||||-||-|||||---||||-|||||||||||  75 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase
 9 17 19 35 |||-|------||||-||-|--|||||||-------|-  93 [P]  COG0474 Cation transport ATPase
10 21 31 49 |||-|||-|||||-|-|||--|||||-|||||||||||  85 [P]  COG0475 Kef-type K+ transport systems, membrane components
11 22 31 50 |-|||||-|||||||-||||--||||-||||||||||-  86 [H]  COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
14 28 38 65 |||||||||||||||||||||||||||||||||||||| 537 [GEPR] COG0477 Permeases of the major facilitator superfamily
 4 10 12 13 -|||-|||||||||------------------------  14 [T]  COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
10 20 29 48 ||-||-|||||||-|-|||-|-|-|--|||||||||||  62 [C]  COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  97 [J]  COG0480 Translation elongation factors (GTPases)
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [M]  COG0481 Membrane GTPase LepA
11 18 26 51 -----------||-||||||||||||||||||||||||  58 [J]  COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain
11 21 31 50 ||||-|||||||--|||||--||-||-|||||||||||  92 [G]  COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
13 23 31 58 |-|||------|||||||||||||||||||||||||||  73 [O]  COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain
10 17 25 48 -----------||-||||||||-|||||||||||||||  48 [R]  COG0486 Predicted GTPase
10 17 25 48 -----------|||--|||||||||||||||||||||| 159 [R]  COG0488 ATPase components of ABC transporters with duplicated ATPase domains
12 25 35 55 ||||||||||||||||||||--||||-||||||||||| 104 [D]  COG0489 ATPases involved in chromosome partitioning
 5  6  7 10 ------|-------|---|---||||------------  11 [P]  COG0490 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels
12 25 34 56 ||||||||||||||||||||--||||-||||||||||- 271 [R]  COG0491 Zn-dependent hydrolases, including glyoxylases
14 27 37 65 ||||||||||||-||||||||||||||||||||||||| 121 [O]  COG0492 Thioredoxin reductase
12 19 26 42 --|-||--|-||||||-||--|||||-||||-|-||||  77 [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
14 24 34 57 |-|||-|-||||||||||||||||||-||||||||||| 335 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0495 Leucyl-tRNA synthetase
10 19 26 38 ||||--|||-||--|||||-||-----||||||||||-  41 [R]  COG0496 Predicted acid phosphatase
 8 13 21 41 --------------|-||||-|||||-|||||||||||  41 [L]  COG0497 ATPase involved in DNA repair
10 23 32 53 |||||||||||||-|||||---||||-||||||||||-  70 [E]  COG0498 Threonine synthase
 8 19 23 31 |||||||||||||-||||----|----|-|--|--||-  32 [H]  COG0499 S-adenosylhomocysteine hydrolase
14 27 37 61 ||||||||||||||||||||||||||-||||||||||| 786 [QR] COG0500 SAM-dependent methyltransferases
11 24 33 53 |||||||||||||||-||||--||||-||||||||||- 110 [O]  COG0501 Zn-dependent protease with chaperone function
10 19 25 41 |||----|---||-||||-||-|||--||||||||||-  49 [H]  COG0502 Biotin synthase and related enzymes
11 23 30 54 ||||-|-||||||--|||||-||||||||-|||||-|-  93 [F]  COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
13 27 37 63 |||||||||||||||||||-||||||||||||||||||  67 [F]  COG0504 CTP synthase (UTP-ammonia lyase)
11 23 31 51 |||||-||||-||-||||||--||||-||||||||||-  55 [EF] COG0505 Carbamoylphosphate synthase small subunit
 7 12 16 30 ---|-------||---|||---|-|--||--||||||-  32 [E]  COG0506 Proline dehydrogenase
 9 15 20 37 -|---------||---|-|-||||||||||||-||-|-  52 [L]  COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member
 9 15 25 48 ---||---|||||---|||-|-|-||||||||||-||| 122 [C]  COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes
11 18 25 41 ---|||---||||-|||||-|-|-|||||||-||-||-  50 [E]  COG0509 Glycine cleavage system H protein (lipoate-binding)
 5  8 11 22 -----------||------|-|--|||-|-||----|-  27 [M]  COG0510 Predicted choline kinase involved in LPS biosynthesis
13 23 30 51 |||--||--|-||-||||||||||||-||||||||||-  78 [I]  COG0511 Biotin carboxyl carrier protein
11 24 33 54 |||||||||||||-||||||--||||-||||||||||-  79 [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II
12 23 31 55 |||-|-|--|-||||-||||-||||||||||||||||| 218 [LKJ] COG0513 Superfamily II DNA and RNA helicases
11 16 23 34 --|-------||||--||||-|||||-|||||||-||-  46 [L]  COG0514 Superfamily II DNA helicase
11 19 25 41 ---||---||-||||-|||-|-|||||||||||-|-|- 407 [RTKL] COG0515 Serine/threonine protein kinase
13 24 31 53 ||-|||-|--|||-||||||||||||-||||||||||- 138 [F]  COG0516 IMP dehydrogenase/GMP reductase
13 26 36 59 |||||||||||||-||||||||||||-||||||||||| 330 [R]  COG0517 FOG: CBS domain
13 26 35 56 |||||||||||||-||||||||||||-||||||||||-  83 [F]  COG0518 GMP synthase - Glutamine amidotransferase domain
13 26 35 56 |||||||||||||-||||||||||||-||||||||||-  56 [F]  COG0519 GMP synthase, PP-ATPase domain/subunit
12 22 29 53 |-||-|-|-||-|--||||||||||||||||||-|||-  89 [E]  COG0520 Selenocysteine lyase
 8 19 25 43 |||||||||||---|-|-|---|||--||-|||-|||-  54 [H]  COG0521 Molybdopterin biosynthesis enzymes
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  76 [J]  COG0522 Ribosomal protein S4 and related proteins
 9 14 19 32 --|--------||-|-||||--|-|--||||-|||||-  67 [R]  COG0523 Putative GTPases (G3E family)
 9 21 29 47 |||||||||||||--||||---||||-||||||--||- 202 [G]  COG0524 Sugar kinases, ribokinase family
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0525 Valyl-tRNA synthetase
14 27 37 65 |||||||-|||||||||||||||||||||||||||||| 357 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins
11 24 34 56 |||||||||||||-|||||-|-||||-|||||||||||  85 [E]  COG0527 Aspartokinases
12 25 35 63 |||||||||||---||||||||||||||||||||||||  63 [F]  COG0528 Uridylate kinase
 9 15 19 28 -----||---|||-|--||---|||--||||-|-|||-  33 [P]  COG0529 Adenylylsulfate kinase and related kinases
 9 18 21 28 ||||||||||-||-||-|---|--|---|-||----|-  37 [P]  COG0530 Ca2+/Na+ antiporter
10 22 31 53 |||||-||||||||--||-||-|||||||||||--||| 257 [E]  COG0531 Amino acid transporters
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  72 [J]  COG0532 Translation initiation factor 2 (IF-2; GTPase)
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [O]  COG0533 Metal-dependent proteases with possible chaperone activity
12 23 30 53 ||||-||---|||-||-|||-||||||||||||||||- 140 [V]  COG0534 Na+-driven multidrug efflux pump
 9 20 23 29 |||||||||||---|||||---||||-|----|---|-  98 [R]  COG0535 Predicted Fe-S oxidoreductases
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [R]  COG0536 Predicted GTPase
13 26 36 63 |||||||-|||||||-|||||||||||||||||||||| 108 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
10 17 23 36 ---||-|-|||||-|||||---|-||-||--||-|||-  38 [C]  COG0538 Isocitrate dehydrogenases
11 18 26 49 -----------||-||||||||||||||||||||||||  52 [J]  COG0539 Ribosomal protein S1
11 24 32 53 |||||||||||||-||||||--||||-||||-|||||-  53 [F]  COG0540 Aspartate carbamoyltransferase, catalytic chain
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  66 [U]  COG0541 Signal recognition particle GTPase
13 20 28 52 |----------||||||||||||||||||||||||||| 128 [O]  COG0542 ATPases with chaperone activity, ATP-binding subunit
10 20 25 38 |||-||||-|-||-||---|-|||||-||-|-||--||  67 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
10 16 24 50 --------------||||||||||||||||||||||||  51 [O]  COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)
 7 11 16 24 -----------||---|||-|||----|||||||-|--  45 [O]  COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1
 9 19 26 46 |-||-||----|--|-|||--||||||||||||||||-  91 [R]  COG0546 Predicted phosphatases
10 23 32 52 |||||||||||||-|||||---||||-||||||||||-  66 [E]  COG0547 Anthranilate phosphoribosyltransferase
10 21 31 47 |||--||||||||-|||||---||||-|||||||||||  60 [E]  COG0548 Acetylglutamate kinase
 5  9 13 20 ---|||--|-|------|------|||||--|----|-  30 [E]  COG0549 Carbamate kinase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  90 [L]  COG0550 Topoisomerase IA
 7 17 23 42 |||||||--------|---|||-||||||||||||---  57 [L]  COG0551 Zn-finger domain associated with topoisomerase type I
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  66 [U]  COG0552 Signal recognition particle GTPase
12 21 27 41 --|||||--|||||-||||||-||||||||||----|- 109 [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
12 20 27 46 ---||||--|||--||||||-||||||||||||--||-  52 [C]  COG0554 Glycerol kinase
 7 18 25 37 ||||||||||------|||---|||--|||||||-||-  42 [O]  COG0555 ABC-type sulfate transport system, permease component
11 19 27 52 |-||----------||||||||||||||||||||||||  53 [L]  COG0556 Helicase subunit of the DNA excision repair complex
13 20 27 48 ---|-------||||||||||||||||||||||||||-  62 [K]  COG0557 Exoribonuclease R
13 25 35 62 |-|||||-||||||||||-||||||||||||||||||| 104 [I]  COG0558 Phosphatidylglycerophosphate synthase
 9 14 18 25 -|----|-|||----|||||--|-||-||---|-|-|-  73 [E]  COG0559 Branched-chain amino acid ABC-type transport system, permease components
 8 20 27 43 |||||||||-|||------||-||-|-||||||||||-  76 [E]  COG0560 Phosphoserine phosphatase
13 25 31 55 |-||||||||||||-||||||||||||-|-||||--|- 171 [R]  COG0561 Predicted hydrolases of the HAD superfamily
 5  8  8 13 |-----------------|---||--|-|-----|-|-  13 [M]  COG0562 UDP-galactopyranose mutase
13 23 31 58 --||-||----|||||||||||||||||||||||||||  85 [F]  COG0563 Adenylate kinase and related kinases
12 19 27 53 -----------||||||||||||||||||||||||||| 146 [J]  COG0564 Pseudouridylate synthases, 23S RNA-specific
 5 14 22 32 |||||-||-||-----|||--------|||||||-|||  36 [J]  COG0565 rRNA methylase
12 19 27 52 ------|----||-|||||||||||||||||||||||| 109 [J]  COG0566 rRNA methylases
 6  9 16 33 -----------||-----|-|-|-|--|||||||-|||  38 [C]  COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes
10 16 24 50 --------------|||||||||||||||||||||||| 103 [K]  COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)
11 22 27 44 ||||-||||-|---||||||-||-|||||-||-||-|-  70 [P]  COG0569 K+ transport systems, NAD-binding component
11 18 26 52 -----------||-||||||||||||||||||||||||  57 [K]  COG0571 dsRNA-specific ribonuclease
 9 13 16 29 ---|-------||--||||-||-||||-|-||------  35 [F]  COG0572 Uridine kinase
10 22 29 47 ||||-||||||---|||||--||||||-|||||-|||-  54 [P]  COG0573 ABC-type phosphate transport system, permease component
11 23 32 49 |||||||||||---||||||-|||||-||||-||||||  73 [G]  COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  66 [I]  COG0575 CDP-diglyceride synthetase
12 22 30 57 |-|||------||-||||||||||||||||||||||||  60 [O]  COG0576 Molecular chaperone GrpE (heat shock protein)
11 21 28 44 ||||--||||-----|||||||||||-||-|||||||- 169 [V]  COG0577 ABC-type antimicrobial peptide transport system, permease component
10 14 19 36 ---||----|-|||---||--||-||-||||||---|-  53 [C]  COG0578 Glycerol-3-phosphate dehydrogenase
 8 16 21 35 ----|||---|----|||-|--|||-|||||-|||||-  44 [R]  COG0579 Predicted dehydrogenase
11 17 22 38 |-----|--|-|||-|-|||-|-|||||||-||--||-  60 [G]  COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
10 22 30 48 ||||-||||||---|||||--||||||||||||-|||-  57 [P]  COG0581 ABC-type phosphate transport system, permease component
11 23 32 56 |||||||--||---|||||||-|||||||||||||||| 371 [L]  COG0582 Integrase
 8 16 23 40 ||----||------|-||||--||||-||||||||||- 904 [K]  COG0583 Transcriptional regulator
12 19 25 44 ---|||--|-||||-||-||-||||||||-|||--||-  93 [C]  COG0584 Glycerophosphoryl diester phosphodiesterase
 7 16 21 30 |||||||||||||||---|--------||-||--|---  31 [S]  COG0585 Uncharacterized conserved protein
 8 13 20 38 ----|----|------|||--|||||-||||||||||-  89 [S]  COG0586 Uncharacterized membrane-associated protein
10 16 24 50 --------------||||||||||||||||||||||||  67 [L]  COG0587 DNA polymerase III, alpha subunit
 8 12 17 34 --|--------||------|||||||--||-|||-||-  37 [G]  COG0588 Phosphoglycerate mutase 1
 9 19 28 48 |||||||||||-|-|-|||---|-||-||-||||-||| 207 [T]  COG0589 Universal stress protein UspA and related nucleotide-binding proteins
10 15 23 42 --|--------||||-|||-|-||||-|||||||-|||  65 [FJ] COG0590 Cytosine/adenosine deaminases
 9 18 25 41 |-|||||--||||----|-||-|-||-||-|||||-||  70 [ER] COG0591 Na+/proline symporter
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  74 [L]  COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
 9 15 23 49 --------------|||||-||||||||||||||||||  73 [L]  COG0593 ATPase involved in DNA replication initiation
 9 15 23 48 ---------------|||||||||||||||||||||||  48 [J]  COG0594 RNase P protein component
 8 17 20 38 ||||-|-|-------|||||--|||||-------||||  55 [R]  COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily
12 22 32 55 --|||-|-|||||||-||||-||||||||||||||||| 481 [R]  COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 
10 16 24 50 --------------||||||||||||||||||||||||  50 [MU] COG0597 Lipoprotein signal peptidase
11 20 28 45 -||--||-||-||-||||||--||||-||||||-||||  78 [P]  COG0598 Mg2+ and Co2+ transporters
 9 17 23 32 |||-|-||-|-||--|-||---|-||-|||-|||-||-  64 [S]  COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
 9 16 20 30 -||---||-------||||||-||||-||--||--||-  92 [P]  COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
12 22 28 52 --|||||-|||---|||||||||||||||-|||-|-|- 244 [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
 7 19 28 47 ||||||||||----|-||-|---|||-|||||||||||  61 [O]  COG0602 Organic radical activating enzymes
 6 18 27 43 |||||||||||---|-||-----||--|||||||||||  47 [R]  COG0603 Predicted PP-loop superfamily ATPase
 9 14 21 35 --|||---||-||-|-|-|---|-||-||||||--||- 139 [CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases
12 21 31 54 |-|||---|||||||-|||-||||||-|||||||||||  74 [P]  COG0605 Superoxide dismutase
10 15 22 35 |------|------||||||-|||---|||||||||||  40 [O]  COG0606 Predicted ATPase with chaperone activity
12 22 31 52 |-|||-|-||-||||-||||-|||||-||||||||||| 168 [P]  COG0607 Rhodanese-related sulfurtransferase
12 24 33 54 ||||||||||----||||||||||||-|||||||||||  76 [L]  COG0608 Single-stranded DNA-specific exonuclease
 9 20 27 44 -||||||-|||----|||||--|||||||-|||-|||- 164 [P]  COG0609 ABC-type Fe3+-siderophore transport system, permease component
 4 13 19 27 ||||-||---------|-------||||-|||-|||||  44 [V]  COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
 7 18 25 38 |||||||||||---|-||----|-|--|||||||||--  38 [H]  COG0611 Thiamine monophosphate kinase
11 17 25 43 --------|-|||-||||||-|||||-||||||-||||  91 [R]  COG0612 Predicted Zn-dependent peptidases
 8 15 20 26 ||||--|--||---|||||----||--||-||||----  34 [R]  COG0613 Predicted metal-dependent phosphoesterases (PHP family)
 9 19 26 46 -||||||-|||----|||||--||||-||-|||-|||- 181 [P]  COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component
 7 15 18 22 |||||||||||||||---------||-----------|  26 [MI] COG0615 Cytidylyltransferase
12 22 30 51 |||||||-|-|---|||||||||-|--|||||||||||  89 [OU] COG0616 Periplasmic serine proteases (ClpP class)
12 18 26 49 -----------|||||||||||||||-|||||||||||  75 [J]  COG0617 tRNA nucleotidyltransferase/poly(A) polymerase
11 19 21 33 -|||-||||-|---||||||-||||||---|-------  48 [R]  COG0618 Exopolyphosphatase-related proteins
 9 19 22 38 ||||-|||-||----|||||--|||||-|--|----|-  70 [P]  COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
 9 20 29 46 |||||||||||||-||----|-|-||-||||||||||-  60 [E]  COG0620 Methionine synthase II (cobalamin-independent)
12 24 33 53 |||||||||||---|||||||||||--|||||||||||  90 [J]  COG0621 2-methylthioadenine synthetase
 9 18 23 35 ||||-||||||||--|---|-||||||||-|-------  48 [R]  COG0622 Predicted phosphoesterase
 7 11 17 35 --------------|-|||-|-|-||-||--|||||||  39 [I]  COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)
11 20 30 53 -|--|||||||||-||--|||-||||-||||||||||| 157 [E]  COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases
 4  8 15 26 -----------||---||-------|-|||||||-||| 194 [O]  COG0625 Glutathione S-transferase
 9 17 26 47 --||||--|||||--|--||--||||-||||||||||- 107 [E]  COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases
 5  8 13 28 -----------|----||----|-||-||--|||-||-  52 [R]  COG0627 Predicted esterase
10 20 28 50 ||||-||-------||||||-|||||-||||||||||| 128 [R]  COG0628 Predicted permease
11 18 26 52 -----------||-||||||||||||||||||||||||  82 [L]  COG0629 Single-stranded DNA-binding protein
 3 10 14 21 -||||||-|||------------------|----||||  52 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis
 9 16 18 31 ----|------||-|-|||-|-||||||-|--|-|-|-  55 [T]  COG0631 Serine/threonine protein phosphatase
 9 15 23 48 ---------------|||||||||||||||||||||||  48 [L]  COG0632 Holliday junction resolvasome, DNA-binding subunit
 9 13 19 31 ---|-------||||-|||-|-|----||-||||-|||  69 [C]  COG0633 Ferredoxin
 7 11 18 38 --------------||--||--||||||||||||-||-  39 [F]  COG0634 Hypoxanthine-guanine phosphoribosyltransferase
10 16 24 46 --------------||||||||||||||||||||||||  85 [H]  COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases
14 28 37 65 ||||||||-|||||||||||||||||||||||||||||  77 [C]  COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K
10 18 26 44 --|-||--||-||--||||-|-||||||||||||-||- 109 [R]  COG0637 Predicted phosphatase/phosphohexomutase
 5 13 15 19 ||||||||||||||--------|---------------  79 [O]  COG0638 20S proteasome, alpha and beta subunits
10 22 31 45 -|||||||||||||-|||||---|||-||||||||||- 112 [T]  COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
10 22 31 48 |||||||||||---||||||--||||-||||||||||- 281 [K]  COG0640 Predicted transcriptional regulators
 6 11 12 17 |||---|--|-----|||-----|----|--|----|-  37 [R]  COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)
12 21 29 50 |-||--|----||-||||||||||||-||||||||||| 798 [T]  COG0642 Signal transduction histidine kinase
 7 15 19 31 --||-||--------||||--|-||--||||-|-|||-  46 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases
10 21 27 39 |||||||||||||-||||-|--||---|||--||-||-  98 [C]  COG0644 Dehydrogenases (flavoproteins)
 6  8  9 11 ---|----------|-|||---|----|-------||-  13 [R]  COG0645 Predicted kinase
 7 11 14 27 ---------------|||||--|||--||-|-|--||-  30 [E]  COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain
 9 14 19 35 ---|-||--||||-||---|--|-||-||-----||||  46 [G]  COG0647 Predicted sugar phosphatases of the HAD superfamily
10 18 21 37 ||||||--||||||||----|-|||-|-|-|-------  39 [L]  COG0648 Endonuclease IV
 8 16 23 38 --|||||-|||---|||||---|----|||--||||||  41 [C]  COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7
 5 10 10 15 |||-||-|-|-----|------|-----|---------  23 [C]  COG0650 Formate hydrogenlyase subunit 4
 8 16 21 33 |||||||-|||----||||---|-|--||-|-----||  69 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit
10 18 25 44 |-||-------|||--||||-|||||-||||||||||-  91 [O]  COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
10 16 24 50 --------------||||||||||||||||||||||||  61 [U]  COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase)
 6 10 17 30 -----------||---|||---|-|--|||||||-||| 109 [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
 9 17 23 33 |||---||-|-||-|---||--||||-||||-|--|||  82 [R]  COG0655 Multimeric flavodoxin WrbA
 9 15 20 37 ---|||--||||||-|-|----||||-||---|--||-  96 [R]  COG0656 Aldo/keto reductases, related to diketogulonate reductase
10 17 22 34 --|-|-|--|-||--||||--|||||-||||-|--||- 105 [I]  COG0657 Esterase/lipase
10 16 24 47 --------------||||||||||||||||||||||||  47 [R]  COG0658 Predicted membrane metal-binding protein
 9 14 18 30 --|--------||||-||--|-|-||-||-|||-|-|-  60 [P]  COG0659 Sulfate permease and related transporters (MFS superfamily)
 7 15 22 34 |-|||----|-||---||----|||--|||||||-|||  52 [R]  COG0661 Predicted unusual protein kinase
 8 17 22 34 |||--|||------||||-|--|-|--||||-|||||-  63 [G]  COG0662 Mannose-6-phosphate isomerase
 8 18 24 37 |||-||-|-|----|-|||---|||--||||-||||||  54 [R]  COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily
12 18 25 42 -----------|||||||||||||||-||||||||||- 178 [T]  COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
11 21 30 51 --|||||-|||||-|-|||-||||||-||||||||||- 225 [E]  COG0665 Glycine/D-amino acid oxidases (deaminating)
11 16 23 32 ----|---|--|||--||||-|||---|||||||||||  96 [R]  COG0666 FOG: Ankyrin repeat
12 18 25 38 ---||---|||||-||||||-||-||-||||-|-|||- 153 [C]  COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)
13 25 34 56 |||||||||||-||||||||-|||||-||||-|||||| 141 [M]  COG0668 Small-conductance mechanosensitive channel
 9 15 22 43 --------------||||||-||||||||||||||||-  43 [H]  COG0669 Phosphopantetheine adenylyltransferase
 8 15 22 39 -----------||---||||||-||||||-||||||||  51 [R]  COG0670 Integral membrane protein, interacts with FtsH
12 23 30 49 ||||-|-|-|-||||-||||-|||||-||||||-|||| 120 [I]  COG0671 Membrane-associated phospholipid phosphatase
 9 14 17 24 ------|---|||--|||-|-|--|--||--|-||-||  26 [P]  COG0672 High-affinity Fe2+/Pb2+ permease
10 21 27 43 |-||||-|||-||-|||||---||||-||-|||-|||- 229 [R]  COG0673 Predicted dehydrogenases and related proteins
11 22 26 37 |||||||||||||-||||-|-|||||--|-|---|---  81 [C]  COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit
 9 16 18 25 -|||||-|||----|||||--||-----||----|--- 189 [L]  COG0675 Transposase and inactivated derivatives
 3  3  7 12 -----------|----------|----|||||------  14 [G]  COG0676 Uncharacterized enzymes related to aldose 1-epimerase
 5 10 14 21 ||---|--|------|-------||--||||||---|-  24 [M]  COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase
 3  7 11 16 -----------||---||----------|-||||-||-  20 [O]  COG0678 Peroxiredoxin
 9 17 24 34 ||-----|---||-||||-|--||||-||||||-||||  50 [R]  COG0679 Predicted permeases
 6 13 13 19 |||--|||-|----|-||-----|----|-----|---  37 [C]  COG0680 Ni,Fe-hydrogenase maturation factor
14 28 38 63 ||||||||||||||||||||||||||||||||||||||  93 [U]  COG0681 Signal peptidase I
10 16 24 50 --------------||||||||||||||||||||||||  50 [M]  COG0682 Prolipoprotein diacylglyceryltransferase
 9 15 19 26 -|-|--|-|||----|||||--|-||-||---|-|-|- 112 [E]  COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
 6 12 15 25 |||---||---|------|---|-|--||-|||---|-  34 [H]  COG0684 Demethylmenaquinone methyltransferase
10 18 27 43 --|-||--|||||-|||||---||||-||||||||||-  51 [E]  COG0685 5,10-methylenetetrahydrofolate reductase
 5  8 10 17 ----------------|||---|-||----|---|||-  20 [E]  COG0686 Alanine dehydrogenase
 9 15 22 38 ---|--|-|-|----|||||-|-||||||-||||-||- 114 [E]  COG0687 Spermidine/putrescine-binding periplasmic protein
 8 18 24 40 ||||--||---||-----|||-|||--||||||||-||  45 [I]  COG0688 Phosphatidylserine decarboxylase
11 18 27 44 |---|||||||||||-|-||--|-|--|||||||-|||  49 [J]  COG0689 RNase PH
10 16 24 50 --------------||||||||||||||||||||||||  50 [U]  COG0690 Preprotein translocase subunit SecE
10 16 24 50 --------------||||||||||||||||||||||||  50 [O]  COG0691 tmRNA-binding protein
 9 14 20 42 -----------|||----|||||-|||||||||||-|-  43 [L]  COG0692 Uracil DNA glycosylase
11 24 32 48 -||||||||||||-|-||||-||||||||||||-|||- 110 [R]  COG0693 Putative intracellular protease/amidase
 6 11 17 33 ---|--|----||---||--|---|--|||||--||||  39 [O]  COG0694 Thioredoxin-like proteins and domains
 9 17 25 42 |-||--|----|||-||||---||||-|||||||-|||  82 [O]  COG0695 Glutaredoxin and related proteins
 5 11 13 25 --||---------|--||-----||-|||-|---|-|-  27 [G]  COG0696 Phosphoglyceromutase
14 25 35 57 |-|||||-||||||||||||||||||-||||||||||| 386 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
 7 11 14 31 --------------||-|-|--|||||-|--|--|-||  47 [G]  COG0698 Ribose 5-phosphate isomerase RpiB
 7 11 12 19 -----------|||--|||---|-|--||---|-|---  44 [R]  COG0699 Predicted GTPases (dynamin-related)
 3  5  7 11 -----------------|-----||--||-|-|-----  11 [S]  COG0700 Uncharacterized membrane protein
 7 14 15 21 |||---||------||||----||||--|-----|---  26 [R]  COG0701 Predicted permeases
 8 12 18 28 ---|-------||-|-|||---|-||-||||||--||- 102 [MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases
11 17 24 45 --|--------||-|||||||-||||-||||||||||-  52 [E]  COG0703 Shikimate kinase
10 22 29 47 |||||||||||---|||||--||||||||||-|--||-  82 [P]  COG0704 Phosphate uptake regulator
11 23 31 48 -||||||||||||-|||||--|||||-||||||-|||-  69 [R]  COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
11 18 26 52 -----------||-||||||||||||||||||||||||  62 [U]  COG0706 Preprotein translocase subunit YidC
12 18 26 49 --|----|-|----||||||||||||-|||||||||||  56 [M]  COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase
11 20 28 47 |-|-|-|--|-|||--||||-|||||-|||||||||||  65 [L]  COG0708 Exonuclease III
 4  7 10 15 -|-----|||----|------------||--|--|-|-  15 [E]  COG0709 Selenophosphate synthase
 7 16 18 28 ||||||||||-||-|-----|---||--|----|----  28 [E]  COG0710 3-dehydroquinate dehydratase
 8 14 22 46 --|-----------||||-|--||||||||||||||||  62 [C]  COG0711 F0F1-type ATP synthase, subunit b
 8 15 23 47 -----------||-||||-|--||||||||||||||||  48 [C]  COG0712 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein)
 7 13 18 32 --|||-----|---|-|||---|----|||--||||||  34 [C]  COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)
10 21 27 42 |||||||||||---|||||--||||--||||-|--||- 105 [R]  COG0714 MoxR-like ATPases
10 18 23 33 -||---||---||--||||||-||||-||-|||--||- 112 [P]  COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
 7 16 21 32 |||---||---||---||-|-|-|||-||||||-|---  71 [C]  COG0716 Flavodoxins
 8 20 28 47 |||||||||||---|-||--|-|||--|||-|||||||  53 [F]  COG0717 Deoxycytidine deaminase
 9 15 23 48 ---------------|||||||||||||||||||||||  48 [S]  COG0718 Uncharacterized protein conserved in bacteria
10 20 25 43 |||||||||||----||||-||||||--||-----||-  85 [O]  COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
 7 19 27 43 ||||||||||----||||-----||--|||||||||||  55 [H]  COG0720 6-pyruvoyl-tetrahydropterin synthase
12 23 28 46 ||||--||-||---||||||||||||||----||||||  47 [J]  COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit
 6  9 15 23 -----------||---|-|---|--|-|||||||-||-  40 [E]  COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase
 9 17 24 36 --|||---|||||-|-|||---|||--|-||-||||||  55 [C]  COG0723 Rieske Fe-S protein
 5  8  8  9 -----------|||--||---|--------|---|--- 121 [R]  COG0724 RNA-binding proteins (RRM domain)
 8 20 26 43 |||||||||||---|-|||---|||--||-|||-|||-  52 [P]  COG0725 ABC-type molybdate transport system, periplasmic component
11 20 25 41 --|-||-|---|||-||||||-||||-||||-|-|||- 122 [G]  COG0726 Predicted xylanase/chitin deacetylase
 6 14 18 27 -|||-||-||------|||------|-||||-|-|-|-  43 [R]  COG0727 Predicted Fe-S-cluster oxidoreductase
10 14 21 39 --------------||||||||||---|||||||||||  41 [R]  COG0728 Uncharacterized membrane protein, putative virulence factor
 3  5 11 20 --------------|----|-------|||||||-||-  22 [M]  COG0729 Outer membrane protein
10 22 31 48 |||||||||||---||||||--||||-||||||||||- 153 [R]  COG0730 Predicted permeases
 8 17 19 23 |||||||||||||--|||-|---|----------|---  30 [C]  COG0731 Fe-S oxidoreductases
 5 14 21 35 |||||||---------|-----|-||||||||--||||  88 [V]  COG0732 Restriction endonuclease S subunits
 8 14 16 25 -|||-||-------|----||||-||----||-||---  43 [R]  COG0733 Na+-dependent transporters of the SNF family
11 19 28 48 --|-|-|-|||---||||||-||||||||||||||||-  91 [P]  COG0735 Fe2+/Zn2+ uptake regulation proteins
10 16 21 46 -----------||-||--|||||||||-|-|-||||||  49 [I]  COG0736 Phosphopantetheinyl transferase (holo-ACP synthase)
10 18 21 33 |--|--|----||-||-||--||||||-|-|||-|-|-  69 [F]  COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases
 3  6  9 15 -----------|------------|---||-|-||||-  17 [G]  COG0738 Fucose permease
 9 14 22 42 --------------||||||-|||||-||||||||||| 147 [M]  COG0739 Membrane proteins related to metalloendopeptidases
10 15 23 46 --------------||||||||||||-|||||||||||  84 [OU] COG0740 Protease subunit of ATP-dependent Clp proteases
 6 11 19 37 --------------||||---|-|||-||||||||||| 114 [M]  COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)
 9 15 23 46 ---------------|||||||||||||||||||||||  46 [L]  COG0742 N6-adenine-specific methylase
10 15 21 37 --------------|||||||||||--||||||||||-  37 [I]  COG0743 1-deoxy-D-xylulose 5-phosphate reductoisomerase
 7 12 19 39 ---------------|||||--||||-||||||||||-  91 [M]  COG0744 Membrane carboxypeptidase (penicillin-binding protein)
 9 14 22 43 --------------|||||||-||||-||||||||||| 429 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
 8 19 26 43 |||||||||||---|-|||---|-|--||-|||||||-  45 [H]  COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A
11 20 26 46 --|||||-|||---|||||||-||||-||-|||-|-|- 248 [E]  COG0747 ABC-type dipeptide transport system, periplasmic component
 2  5  7 12 ----------------||---------|--||--|-|-  14 [P]  COG0748 Putative heme iron utilization protein
11 16 24 46 -----------|--||||||||||||-|||||||||||  46 [L]  COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains
12 24 34 58 |||||||||||---||||||||||||-|||||||||||  78 [M]  COG0750 Predicted membrane-associated Zn-dependent proteases 1
 7 11 19 37 --------------||||-||---||-|||||||||||  37 [J]  COG0751 Glycyl-tRNA synthetase, beta subunit
 7 11 19 37 --------------||||-||---||-|||||||||||  37 [J]  COG0752 Glycyl-tRNA synthetase, alpha subunit
 5  9 13 27 -----------||-----|---|-|--||-|||||-|-  37 [P]  COG0753 Catalase
 2  4  6 12 -----------------|----------|--|--|||-  21 [E]  COG0754 Glutathionylspermidine synthase
 8 13 21 38 --|---|-|-|---|-|||---|-|--|||||||||||  42 [O]  COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component
 9 14 21 40 -----------||||----|||||||-|||-|||||||  46 [F]  COG0756 dUTPase
 7 12 17 28 ---------------|||||--|||--||||||-|||-  31 [E]  COG0757 3-dehydroquinate dehydratase II
 9 15 23 42 --------------||||||-|||||||||||||||||  46 [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake
10 15 23 39 --------------||||||||||||-|||||||||||  39 [S]  COG0759 Uncharacterized conserved protein
10 16 24 43 -----------|||||||||-|-|||-||||||||||| 109 [O]  COG0760 Parvulin-like peptidyl-prolyl isomerase
10 15 21 38 --------------|||||||||||--||||||||||-  40 [IM] COG0761 Penicillin tolerance protein
 8 13 18 37 ---------------|||-|||||||-||-|||-|||-  39 [S]  COG0762 Predicted integral membrane protein
 5  9 16 29 --------------|-||-||------|||||||||||  29 [M]  COG0763 Lipid A disaccharide synthetase
 8 13 21 40 --------------|||||||--|||-|||||||||||  69 [I]  COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases
10 16 24 41 --|---|-|-|----||||||-||||-||-|||||||| 191 [E]  COG0765 ABC-type amino acid transport system, permease component
10 15 23 46 --------------||||||||||||-|||||||||||  56 [M]  COG0766 UDP-N-acetylglucosamine enolpyruvyl transferase
 4  8 15 29 --------------|-||----|----|||||||||||  49 [Q]  COG0767 ABC-type transport system involved in resistance to organic solvents, permease component
10 15 23 46 --------------||||||||||||-||||||||||| 107 [M]  COG0768 Cell division protein FtsI/penicillin-binding protein 2
11 17 25 48 |------|------||||||||||||-|||||||||||  63 [M]  COG0769 UDP-N-acetylmuramyl tripeptide synthase
11 19 27 50 |||----|------||||||||||||-|||||||||||  50 [M]  COG0770 UDP-N-acetylmuramyl pentapeptide synthase
11 17 25 48 |------|------||||||||||||-|||||||||||  48 [M]  COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase
10 15 23 46 --------------||||||||||||-|||||||||||  92 [D]  COG0772 Bacterial cell division membrane protein
10 15 23 46 --------------||||||||||||-|||||||||||  60 [M]  COG0773 UDP-N-acetylmuramate-alanine ligase
 5  9 16 29 --------------|-||-||------|||||||||||  29 [M]  COG0774 UDP-3-O-acyl-N-acetylglucosamine deacetylase
 9 14 20 42 --|------------|--|||||||||||-|||||||-  64 [F]  COG0775 Nucleoside phosphorylase
11 17 25 51 ----|---------|||||||||||||||||||||||| 112 [L]  COG0776 Bacterial nucleoid DNA-binding protein
 8 13 20 39 --------------|-|||||-||||-||||||||||-  40 [I]  COG0777 Acetyl-CoA carboxylase beta subunit
10 22 31 50 |||||||||||---||||||--||||-||||||||||- 161 [C]  COG0778 Nitroreductase
 9 14 22 42 --------------||||||-|||||-|||||||||||  42 [S]  COG0779 Uncharacterized protein conserved in bacteria
 6 10 19 33 --------|-|---||||------||-|||||||||||  34 [R]  COG0780 Enzyme related to GTP cyclohydrolase I
10 16 24 50 --------------||||||||||||||||||||||||  50 [K]  COG0781 Transcription termination factor
 7 12 20 46 ---------------|--|-||||||||||||||||||  83 [K]  COG0782 Transcription elongation factor
 8 13 20 35 ---|------------||||-||-|||||||||-||||  41 [P]  COG0783 DNA-binding ferritin-like protein (oxidative damage protectant)
10 20 25 40 |-||-||----|||-||||--||||--||||||-|||- 545 [T]  COG0784 FOG: CheY-like receiver
11 17 19 30 |-|--||-|-|---||||||-||-||-----|--|-|-  44 [O]  COG0785 Cytochrome c biogenesis protein
 5  7 10 16 -----------------|-|--|-|--||-||-||---  19 [E]  COG0786 Na+/glutamate symporter
 9 14 22 43 ------------|-|-||||-|||||-|||||||||||  58 [M]  COG0787 Alanine racemase
 7 11 16 27 ---|----------|-|||---|-|--||||||-|||-  34 [F]  COG0788 Formyltetrahydrofolate hydrolase
 8 14 22 42 --|---|-------|-||||--||||-||||||||||| 178 [K]  COG0789 Predicted transcriptional regulators
 4  8 13 24 -----------|||----|--------||-|||||||-  93 [R]  COG0790 FOG: TPR repeat, SEL1 subfamily
 6 11 18 35 ----------------|||-|-||||-||||||||||- 123 [M]  COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
 9 13 19 33 --------------||||||-|||---||||||||||-  33 [L]  COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase
11 16 24 42 ----|---||----||||||||-||--|||||||||||  56 [M]  COG0793 Periplasmic protease
 7 16 25 41 |||--||||||---|----||--||--|||||||||||  51 [M]  COG0794 Predicted sugar phosphate isomerase involved in capsule formation
 7 11 18 32 ---------------|||||||-----|||||||||||  66 [R]  COG0795 Predicted permeases
 8 13 19 40 --------------|-||||-|||||-||-|||||||-  41 [M]  COG0796 Glutamate racemase
 5  9 16 29 --------------|-||---|-|---|||||||||||  36 [M]  COG0797 Lipoproteins
 7 14 14 17 |-|--||----|---|||----|||------|-|--|-  22 [P]  COG0798 Arsenite efflux pump ACR3 and related permeases
 9 13 21 43 --------------|||||-|||-||-|||||||||||  43 [S]  COG0799 Uncharacterized homolog of plant Iojap protein
 5 10 17 30 ---------------|||---|-|||-||||||||||-  40 [G]  COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase
10 16 24 44 -----------||-|||||||-||||-|||||||||||  48 [H]  COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
10 16 24 46 --------------||||||||||||||||||||||||  46 [R]  COG0802 Predicted ATPase or kinase
12 21 26 42 |-||-||-|-|---||||||||||||-||--|-||-||  68 [P]  COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
 6 11 13 23 ------------|---|||---|-|-|||--||-|-|-  25 [E]  COG0804 Urea amidohydrolase (urease) alpha subunit
 8 15 24 43 --|||-|-|||---|-|||---|-|--|||||||||||  49 [U]  COG0805 Sec-independent protein secretion pathway component TatC
 9 14 22 44 --------------||||||-|||||-|||||||||||  44 [J]  COG0806 RimM protein, required for 16S rRNA processing
11 18 25 45 ----|-|----||-|||||||-||||-||||||||||-  56 [H]  COG0807 GTP cyclohydrolase II
 8 13 21 39 --------------||||||-|-|||-|||||||||||  41 [J]  COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)
 4  7 13 24 --------------|-|--|-------||||||||||-  40 [M]  COG0810 Periplasmic protein TonB, links inner and outer membranes
 7 13 20 33 |-|----|------|-|||||------|||||||||||  71 [U]  COG0811 Biopolymer transport proteins
10 15 23 46 --------------||||||||||||-|||||||||||  48 [M]  COG0812 UDP-N-acetylmuramate dehydrogenase
 6  9 12 26 ---------|--------||-|--|||-|-||--|-|-  28 [F]  COG0813 Purine-nucleoside phosphorylase
 5  8 11 20 -----------|||------|-|----||-||-||---  75 [E]  COG0814 Amino acid permeases
 8 12 18 35 --------------|||||-|||----||-||||||||  39 [M]  COG0815 Apolipoprotein N-acyltransferase
 9 15 23 47 --------------|||||||-||||||||||||||||  47 [L]  COG0816 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis)
 8 12 19 35 ---------------||||||||----|||||||||||  35 [L]  COG0817 Holliday junction resolvasome, endonuclease subunit
 5 10 16 32 ---------------||||----|||-||||||||-|-  35 [M]  COG0818 Diacylglycerol kinase
 7 11 14 23 ----||--|||||---|-----|-||-----|--|-|-  31 [K]  COG0819 Putative transcription activator
 9 15 22 41 --------------||||||-||||||||||||||||-  46 [R]  COG0820 Predicted Fe-S-cluster redox enzyme
10 15 21 38 --------------|||||||||||--||||||||||-  38 [I]  COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis
12 20 27 53 --||--|----||||||--||||||||||-||||||||  60 [C]  COG0822 NifU homolog involved in Fe-S cluster formation
 4  9 15 27 --|---|---------||--|------||||||-||||  38 [U]  COG0823 Periplasmic component of the Tol biopolymer transport system
10 18 26 43 |-|||---|||---|-||||-||||--||||||||||-  80 [R]  COG0824 Predicted thioesterase
 8 13 20 39 --------------|-|||||-||||-||||||||||-  40 [I]  COG0825 Acetyl-CoA carboxylase alpha subunit
 8 15 20 35 |||----|-|----|-|-||---|||-||-|||||-|-  75 [O]  COG0826 Collagenase and related proteases
 4  7  8 17 -|--------------------||||-----|--|-|-  22 [L]  COG0827 Adenine-specific DNA methylase
 6 12 20 42 --------------|-||--||-|||||||||||||||  46 [J]  COG0828 Ribosomal protein S21
 6 11 13 19 ------------|---|||---|-|-|||--||-|-|-  21 [O]  COG0829 Urease accessory protein UreH
 6 11 13 22 ------------|---|||---|-|-|||--||-|-|-  24 [O]  COG0830 Urease accessory protein UreF
 6 11 13 23 ------------|---|||---|-|-|||--||-|-|-  25 [E]  COG0831 Urea amidohydrolase (urease) gamma subunit
 6 11 13 22 ------------|---|||---|-|-|||--||-|-|-  24 [E]  COG0832 Urea amidohydrolase (urease) beta subunit
 3  7  9 16 -----------||----------|||-||---|-|---  54 [E]  COG0833 Amino acid transporters
11 17 25 46 --|---|-|-|----|||||||||||-||-|||||||| 270 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
 6 14 18 30 --||-||--------|||---|-||--||||-|-|||-  76 [NT] COG0835 Chemotaxis signal transduction protein
 7 13 18 27 --||-||-------|||||----|---||||---||||  37 [M]  COG0836 Mannose-1-phosphate guanylyltransferase
 2  6 10 19 ----------------||---------|||--|||||-  21 [G]  COG0837 Glucokinase
 7 14 21 35 --|||-|-|||---|-|||---|----|||--||||||  38 [C]  COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A)
 7 14 20 34 --|||-|--||---|-|||---|----|||--||||||  40 [C]  COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J)
 7 15 19 31 --||-||--------||||--|-||--||||-|-|||- 323 [NT] COG0840 Methyl-accepting chemotaxis protein
 9 14 21 35 --|-----------||||||-|-||--||||||||||| 149 [V]  COG0841 Cation/multidrug efflux pump
10 22 30 48 |-||||||||||||-||||---||||-||||||-|||- 200 [V]  COG0842 ABC-type multidrug transport system, permease component
 9 12 18 33 ---|----||||--|-|||---|-|--|||--|--|||  60 [C]  COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1
 9 14 22 39 --------------||||||-|||||-||||||||||| 288 [M]  COG0845 Membrane-fusion protein
11 19 25 38 -----|||||||||||--||--|||||||-|||-||--  49 [K]  COG0846 NAD-dependent protein deacetylases, SIR2 family
12 18 26 47 ----|-|----|||||-||-||||||-|||||||||||  95 [L]  COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases
 6 10 17 30 --------------|-|||||------|||||||||||  65 [U]  COG0848 Biopolymer transport protein
 8 12 20 39 -------|------||--||-|-|||-|||||||||||  42 [D]  COG0849 Actin-like ATPase involved in cell division
 7 12 17 29 --------------||||||---||--||||||||-|-  29 [D]  COG0850 Septum formation inhibitor
 4  8 12 22 ----------------||||-------||||-|||-|-  22 [D]  COG0851 Septum formation topological specificity factor
 8 16 23 38 --|||||-|||---|||||---|----|||--||||||  40 [C]  COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit
 7 12 16 30 --------------|||||---|||--|||--|||||-  31 [H]  COG0853 Aspartate 1-decarboxylase
 3  7 12 22 --------------|-||---------||||-|||||-  22 [H]  COG0854 Pyridoxal phosphate biosynthesis protein
 6 11 16 28 --|-------------|||---|||--||||-|||||-  28 [P]  COG0855 Polyphosphate kinase
 1  6  6  7 |||||-|-------------------------------   8 [F]  COG0856 Orotate phosphoribosyltransferase homologs
 5  9 12 22 ---|--|---------|||---|----||-||-||---  23 [R]  COG0857 BioD-like N-terminal domain of phosphotransacetylase
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0858 Ribosome-binding factor A
 4  8 14 22 --------------|-||-|-------||||||||||-  70 [M]  COG0859 ADP-heptose:LPS heptosyltransferase
 9 14 20 40 --------------|-|||||||||--||||||||||-  85 [M]  COG0860 N-acetylmuramoyl-L-alanine amidase
 5 10 17 35 ----------------|||---|||--|||||||||||  74 [P]  COG0861 Membrane protein TerC, possibly involved in tellurium resistance
 7 13 19 29 -|-|||---------||-||----||--|||||||||-  63 [L]  COG0863 DNA modification methylase
 4 13 16 23 ||||-||||||------------||---|-----|||-  30 [K]  COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain
 5 11 11 18 |||---||----------|--|-||---|-------|-  25 [F]  COG1001 Adenine deaminase
 7 15 16 21 -||||---|---------|--||||-|-|--|-|||--  39 [V]  COG1002 Type II restriction enzyme, methylase subunits
10 16 21 35 ---|||---||||-|||||---|-|--|||--||-||-  36 [E]  COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain
 7 15 22 33 -|||-||--|----|-||----|-||-||||||-||||  44 [M]  COG1004 Predicted UDP-glucose 6-dehydrogenase
 7 14 21 35 --|||-|-|||---|-|||---|----|||--||||||  38 [C]  COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H)
 7 13 15 22 ||||-|---------||||---|-|--|--|-----||  33 [P]  COG1006 Multisubunit Na+/H+ antiporter, MnhC subunit
 7 14 21 35 --|||-|-|||---|-|||---|----|||--||||||  37 [C]  COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N)
 6 12 17 31 --|||---------|-|||---|----|||--||||||  40 [C]  COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M)
 8 16 24 42 --|||||-|||---|-|||---|-|--||||-||||||  65 [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit
 7 17 19 24 |||||-||||------||-|--|||--||---|---|-  25 [H]  COG1010 Precorrin-3B methylase
11 20 27 44 ||||-|-|||-|||-||-|--|||||-||-||||-||- 134 [R]  COG1011 Predicted hydrolase (HAD superfamily)
10 22 31 50 |||||--||||||-|-||||--|||||||-|||||||| 358 [C]  COG1012 NAD-dependent aldehyde dehydrogenases
11 22 26 37 |||||||||||||-||||-|-|||||--|-|---|---  79 [C]  COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit
10 22 27 38 |||||||||||---||||-|-|||||--|-|-|-|||-  89 [C]  COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit
 4  8 10 23 ---------------|--|----||||-|-|---|-|-  25 [G]  COG1015 Phosphopentomutase
 6 10 13 19 -----------||-|---|---|-|--||||-|-|-|-  19 [C]  COG1017 Hemoglobin-like flavoprotein
 7 10 15 28 ---|-------||-----||--|-|--||||-||-||-  78 [C]  COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1
 3 11 11 13 |||||||||--||-------------------------  13 [R]  COG1019 Predicted nucleotidyltransferase
 5  9 12 25 -----------||---|-----|-||-||-|-|-|-|- 145 [Q]  COG1020 Non-ribosomal peptide synthetase modules and related proteins
 3  4  6 11 ----------------------|-|--||-|-----|-  11 [Q]  COG1021 Peptide arylation enzymes
10 13 17 22 ---|--|-|-|||||-||-|-||----||-||------  36 [I]  COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
 6  6  7 10 ---|----------|---|---|-||----------|-  10 [G]  COG1023 Predicted 6-phosphogluconate dehydrogenase
10 16 24 39 ---||-|-|||||-|-|-||--||||-||||-|--||| 245 [I]  COG1024 Enoyl-CoA hydratase/carnithine racemase
 4  5  7 12 -----------|||------|------||-|-------  13 [O]  COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like
 5  6  6  8 -----------||-----|-||-|--------------  11 [R]  COG1026 Predicted Zn-dependent peptidases, insulinase-like
 6 10 13 24 ----|----------||-----|||--||-||-||-|-  25 [E]  COG1027 Aspartate ammonia-lyase
13 23 33 57 --|||||-|||||||||||||-||||-||||||||||| 825 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
 1  5  5  5 |||---||------------------------------  12 [C]  COG1029 Formylmethanofuran dehydrogenase subunit B
 5 10 11 16 --|-|||-|-|---|---------|--|----|---|-  18 [O]  COG1030 Membrane-bound serine protease (ClpP class)
 3  8  9 10 -|||-||||-|----|----------------------  10 [C]  COG1031 Uncharacterized Fe-S oxidoreductase
 9 18 23 29 |||-|||||||----|||||--||||-||-|-----|-  87 [C]  COG1032 Fe-S oxidoreductase
 5 11 11 13 -|||-|||-------|-----|--|--|------|---  19 [R]  COG1033 Predicted exporters of the RND superfamily
 7 11 16 29 --------------|||||---||---|||--||||||  30 [C]  COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)
 3  8  8  8 |||---||--------||------------------|-  22 [C]  COG1035 Coenzyme F420-reducing hydrogenase, beta subunit
 1  5  5  5 |||---||------------------------------   8 [C]  COG1036 Archaeal flavoproteins
 4  6  7 15 -----------||---------||||----------|-  16 [C]  COG1038 Pyruvate carboxylase
 3  4  5 13 --------------|-----|---|||-----------  13 [L]  COG1039 Ribonuclease HIII
 9 14 22 40 --------------||||||-|||||-|||||||||||  43 [R]  COG1040 Predicted amidophosphoribosyltransferases
 3 11 13 15 |||||||||||||-------------------------  17 [L]  COG1041 Predicted DNA modification methylase
 4 12 15 23 -|||||||||------|----------||-|--|--|-  47 [C]  COG1042 Acyl-CoA synthetase (NDP forming)
 5  9 16 29 --------------|-||-||------|||||||||||  29 [M]  COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase
 5  9 16 29 --------------|-||-||------|||||||||||  33 [M]  COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
 7 13 19 39 --||--------|--|||----||||-||-|||||||-  53 [E]  COG1045 Serine acetyltransferase
 6 15 22 32 |||||||||||-------||-|-----||||||||---  44 [O]  COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
 8 14 23 38 --|||---|||||-|---|---||||-||||-||-|||  48 [C]  COG1048 Aconitase A
 2  6 11 18 ----------------||---------||||||||-|-  18 [C]  COG1049 Aconitase B
 8 17 24 34 |||--||||||---|-|||---||||-||-|-|--|||  56 [F]  COG1051 ADP-ribose pyrophosphatase
 9 16 24 40 ----||--|||||-|-||-|-|-|||-||-|||||||-  92 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases
12 23 33 53 ||-||-|||||||-|||||||-||||-|||||||||||  83 [C]  COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
 6  9 15 29 ----------------|||-|-|-||-||||-|--|||  29 [R]  COG1054 Predicted sulfurtransferase
 9 15 20 33 ----|||-|||----|||-||-|-|--||-|-|||-|-  44 [P]  COG1055 Na+/H+ antiporter NhaD and related arsenite permeases
 7 14 17 25 |||||||-|||------||---|--|--|--||-----  29 [H]  COG1056 Nicotinamide mononucleotide adenylyltransferase
 9 16 22 45 -----------||-||||-|-||||||||||-|||||-  50 [H]  COG1057 Nicotinic acid mononucleotide adenylyltransferase
10 17 23 39 ---||||-||||---|||||--||||--|-|-||-||-  40 [R]  COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA
 5  7  7  8 -|--|-|--|----||---|------------------   8 [L]  COG1059 Thermostable 8-oxoguanine DNA glycosylase
11 20 22 32 |||||-|||-|---|||||||-|||---|-|---|---  57 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes
11 17 21 32 --|||||-||||||--|-||-|||||--|-|-------  64 [KL] COG1061 DNA or RNA helicases of superfamily II
 6 10 14 25 ---------|-||---||----|-|--||--|||-||-  42 [C]  COG1062 Zn-dependent alcohol dehydrogenases, class III
 9 18 26 41 --|||||--||||--||-|---||||||||||||-||- 159 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
 7 13 19 36 --|-|---|||||---||----|-||-|||--|||-|-  83 [R]  COG1064 Zn-dependent alcohol dehydrogenases
10 15 23 42 --------------||||||||||||-|||||||||||  43 [O]  COG1066 Predicted ATP-dependent serine protease
 5 13 16 24 ||||||||-------|-----|-||--||-||------  32 [O]  COG1067 Predicted ATP-dependent protease
 3  4  4 13 -----------|------------|---|-------|-  17 [C]  COG1069 Ribulose kinase
 9 14 17 32 ------|---|||--|||---|||||-||--||---|-  90 [G]  COG1070 Sugar (pentulose and hexulose) kinases
10 16 21 35 ---||---||||||--|||-|-|-||||----|--|||  58 [C]  COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
 5  7 10 25 ----|------||---------|-||--|-||----|-  33 [H]  COG1072 Panthothenate kinase
12 19 25 38 --||-||---||||-||-|||-||||-||||||--||-  89 [R]  COG1073 Hydrolases of the alpha/beta superfamily
 6 10 18 39 -------------------|||||||-|||||||||||  39 [L]  COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)
 7 12 14 16 ------|----||---|||---|||-||-||-|-----  24 [R]  COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold
 4  8 14 25 -----------|||---|---------||-||||||||  37 [O]  COG1076 DnaJ-domain-containing proteins 1
 9 16 21 34 |---|-||------|||--|||-||--||||||-||-|  43 [D]  COG1077 Actin-like ATPase involved in cell morphogenesis
 7 15 18 27 |||||||||||--|||---|----|||-----------  34 [R]  COG1078 HD superfamily phosphohydrolases
 8 14 16 27 ---|-||-|-|----||-|--|-|||||----|---|-  42 [R]  COG1079 Uncharacterized ABC-type transport system, permease component
 7 11 18 33 ------------------||||||||||||||||-||-  49 [G]  COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)
 7 16 19 33 |||--|||-|-----|||----||||-||---|--||- 115 [G]  COG1082 Sugar phosphate isomerases/epimerases
 3  5  5  7 --|--------------|-------------|-||---   9 [M]  COG1083 CMP-N-acetylneuraminic acid synthetase
 4 12 14 16 ||||||||||||||------------------------  16 [R]  COG1084 Predicted GTPase
 7 11 13 19 --|--||-|--||--|------||-|--|-||------  21 [C]  COG1085 Galactose-1-phosphate uridylyltransferase
 7 11 18 26 -|-------------|---|-|||||-|-|||||||||  34 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases
 9 16 22 37 |----------||-|-||||--|||||||-|||||||-  54 [M]  COG1087 UDP-glucose 4-epimerase
 9 17 24 38 |-|-|||--||-|---||||--||||-|||-|||-||-  45 [M]  COG1088 dTDP-D-glucose 4,6-dehydratase
 6 11 15 22 |-|---|-------|-||----||---||||---|||-  29 [M]  COG1089 GDP-D-mannose dehydratase
 5  6  9 21 ----|-----------||----|-|--|||-|------  21 [R]  COG1090 Predicted nucleoside-diphosphate sugar epimerase
 9 18 25 36 |-|||||--||---|-||||--||||-|||--||-|||  44 [M]  COG1091 dTDP-4-dehydrorhamnose reductase
 9 13 19 35 -|---|-|--|---||--|||---||-|||||||--|-  48 [R]  COG1092 Predicted SAM-dependent methyltransferases
 4 12 14 16 ||||||||||||||------------------------  16 [J]  COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)
 4 12 14 16 ||||||||||||||------------------------  19 [R]  COG1094 Predicted RNA-binding protein (contains KH domains)
 4 12 14 16 ||||||||||||||------------------------  19 [K]  COG1095 DNA-directed RNA polymerase, subunit E'
 3  9 11 13 |-|-|||||||||-------------------------  13 [J]  COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain)
 4 10 12 14 |-|-||||||||||------------------------  17 [J]  COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)
 3  4  5 10 ---------------|--|----|||------------  14 [J]  COG1098 Predicted RNA binding protein (contains ribosomal protein S1 domain)
 2  5  5  5 ||----||--------|---------------------   7 [R]  COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold
 8 17 19 21 |||||||||||||||-|||-----------------|- 114 [R]  COG1100 GTPase SAR1 and related small G proteins
 4  6  8 13 -------------------|--|--|-|--|-|---||  13 [R]  COG1101 ABC-type uncharacterized transport system, ATPase component
 3 10 12 15 |||||||||||----------|----------------  15 [F]  COG1102 Cytidylate kinase
 1  5  5  5 |||---||------------------------------   6 [R]  COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes
13 20 27 49 --|---|----|||||||||||||||-||-||||||||  76 [E]  COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes
 7 10 14 27 ---------------|--||-||||||||-|||-----  38 [G]  COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)
 5  6  6  8 -|---|---|------|--|--------------|---  14 [R]  COG1106 Predicted ATPases
 1  7  7  8 ||||-|||------------------------------   9 [L]  COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain
12 21 27 47 |-||-||-|-|---||||||||||||-||-||-||-||  81 [P]  COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
14 28 38 65 |||||||||||||||||||||||||||||||||||||| 147 [G]  COG1109 Phosphomannomutase
 4  7  9 10 -|---||||||---||----------------------  16 [L]  COG1110 Reverse gyrase
 2 10 10 12 ||||||||---||-------------------------  13 [L]  COG1111 ERCC4-like helicases
11 23 25 34 ||||||||-|-|||||-|-|--|||-||||----|--|  60 [L]  COG1112 Superfamily I DNA and RNA helicases and helicase subunits
 3  5  7 19 ----------------------||||-||-------|-  77 [E]  COG1113 Gamma-aminobutyrate permease and related permeases
 6  7 11 19 -------------------|||||||-||-||------  24 [E]  COG1114 Branched-chain amino acid permeases
 8 12 16 29 --|--|------------|||||-||-||-||-||-|-  57 [E]  COG1115 Na+/alanine symporter
10 18 24 35 -||-|-||||-----||||||-||||-|||-||--||-  90 [P]  COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component
10 22 30 48 ||||-||||||---|||||--||||||||||||-|||-  64 [P]  COG1117 ABC-type phosphate transport system, ATPase component
 4  8 13 24 ----------------||----|-|--||||-|||||-  34 [P]  COG1118 ABC-type sulfate/molybdate transport systems, ATPase component
 6  7  9 19 --|--------||-----|---|-||--|--|------  20 [P]  COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA
 9 20 26 44 -||||||--||----|||||--|||||||-|||-|||- 118 [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components
12 21 28 47 |-||-||-|||---||||||||||||-||-||-||-||  70 [P]  COG1121 ABC-type Mn/Zn transport systems, ATPase component
10 21 26 42 ||||-||||||----|||||-||||||-|-|||---|- 102 [P]  COG1122 ABC-type cobalt transport system, ATPase component
 7 15 16 26 |||-|--|-|------||-|--|-|---|-|-|-|-|-  72 [R]  COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase
 5  8  9 19 --|-|--------------||---|||-|-------|-  28 [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
 7 10 12 25 ------|---------|-||--||||-||-----|-|-  31 [E]  COG1125 ABC-type proline/glycine betaine transport systems, ATPase components
10 16 24 41 --|---|-|-|----||||||-||||-||-|||||||| 130 [E]  COG1126 ABC-type polar amino acid transport system, ATPase component
 4  8 15 29 --------------|-||----|----|||||||||||  35 [Q]  COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component
 6  9 14 24 ---------------|---|-||-|||||-|||--||- 168 [G]  COG1129 ABC-type sugar transport system, ATPase component
11 24 33 54 |-||||||||||||-||||--||||||||||||||||- 323 [V]  COG1131 ABC-type multidrug transport system, ATPase component
13 22 31 57 --||-|--||-||||||||||-|||||||||||||||| 302 [V]  COG1132 ABC-type multidrug transport system, ATPase and permease components
 1  3  3  9 ----------------------------|-----|-|-   9 [I]  COG1133 ABC-type long-chain fatty acid transport system, fused permease and ATPase components
 6 12 19 30 --|---|-------|-||----||||-|||||-|||||  38 [GM] COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component
 8 13 20 36 ----------------||||||||||-||||||||||-  41 [P]  COG1135 ABC-type metal ion transport system, ATPase component
12 23 33 58 ||||--|||||---|||||||||||||||||||||||| 228 [V]  COG1136 ABC-type antimicrobial peptide transport system, ATPase component
 8 12 19 33 --------------||||||||-----|||||||||||  33 [R]  COG1137 ABC-type (unclassified) transport system, ATPase component
 4  6 13 22 --|---|-|-|-------|--------|||||---|||  29 [O]  COG1138 Cytochrome c biogenesis factor
 6 11 16 23 |--||-|-|||-------||----||--|--||||---  24 [C]  COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain
 4  6  8 14 --------|-|-----------|-|--||---|---|-  18 [C]  COG1140 Nitrate reductase beta subunit
 6 11 13 19 |--|-||-|-|----|||----||||------------  27 [C]  COG1141 Ferredoxin
 4 10 10 15 |||--|||-------|||----------|---------  45 [C]  COG1142 Fe-S-cluster-containing hydrogenase components 2
 8 18 25 40 |||||||-|||---|||||---|----|||--||||||  52 [C]  COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)
 5 11 12 15 |||-||||||----||------------------|---  22 [C]  COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit
 8 19 26 38 |||-|||||||----|||||---||--||||||||-|- 184 [C]  COG1145 Ferredoxin
 8 19 25 38 ||||||||||-----||||---||---||||-|-||||  84 [C]  COG1146 Ferredoxin
 4  8  8  8 |||---||-|----||----------------------  13 [C]  COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins
 2  7  7  8 |||--|||-------|----------------------  16 [C]  COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain
 3  7  7  7 |||---||-|----|-----------------------  11 [C]  COG1150 Heterodisulfide reductase, subunit C
 5 10 10 14 |||--|||-------|---|---|----|---------  19 [C]  COG1151 6Fe-6S prismane cluster-containing protein
 1  5  5  5 |||---||------------------------------  10 [C]  COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit
 1  5  5  5 |||---||------------------------------   9 [C]  COG1153 Formylmethanofuran dehydrogenase subunit D
10 15 22 40 --------------||||||||||||-||||||||||-  44 [HI] COG1154 Deoxyxylulose-5-phosphate synthase
 9 17 19 24 ||||||||||||||----||||---|------------  31 [C]  COG1155 Archaeal/vacuolar-type H+-ATPase subunit A
 9 17 19 24 ||||||||||||||----||||---|------------  26 [C]  COG1156 Archaeal/vacuolar-type H+-ATPase subunit B
 6 10 13 27 --------------||----||-||--||-|-|-|||-  41 [NU] COG1157 Flagellar biosynthesis/type III secretory pathway ATPase
 9 13 20 41 --------------||--|||||||--|||||||||||  41 [K]  COG1158 Transcription termination factor
 9 15 23 48 --------------||||||-|||||||||||||||||  48 [R]  COG1159 GTPase
10 16 24 50 --------------||||||||||||||||||||||||  52 [R]  COG1160 Predicted GTPases
10 18 21 31 -||--|-|||||||-|||-|-|-||||---|--|----  51 [R]  COG1161 Predicted GTPases
 9 14 20 37 --|-----------||||-|-|||||||||||||--|-  40 [R]  COG1162 Predicted GTPases
 4 12 14 16 ||||||||||||||------------------------  19 [R]  COG1163 Predicted GTPase
 8 12 14 29 --||-----------|--||||--|||---|---|||-  41 [E]  COG1164 Oligoendopeptidase F
 5  6  9 19 ---|------------||----|-||--|-||------  19 [H]  COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
 3  6 10 17 ----------------|||--------|||||-||---  18 [E]  COG1166 Arginine decarboxylase (spermidine biosynthesis)
10 15 22 38 ----||--|||||--||-||--||||-||-|||--||- 107 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
 5  7  9 19 ------------------||--||||--|--||-----  21 [E]  COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
 5  7 11 21 ---|------------||----|-||-||-||----|-  27 [HQ] COG1169 Isochorismate synthase
10 16 26 44 ---||---|||||--|||||--|-||-|||||||||||  75 [E]  COG1171 Threonine dehydratase
 5  7 12 22 ---------------|---|--|-||-||-|||--||- 175 [G]  COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components
12 22 28 51 --|||||-|||---|||||||||||||||-|||-|-|- 241 [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
 7 11 13 26 ------|---------|-||--||||-||---|-|-|-  54 [E]  COG1174 ABC-type proline/glycine betaine transport systems, permease component
 9 16 23 42 ---|||--|||----||||--||||||||||||---|- 219 [G]  COG1175 ABC-type sugar transport systems, permease components
 9 14 21 37 ---|--|-|-|----||-||-|-||||||-||||-||-  88 [E]  COG1176 ABC-type spermidine/putrescine transport system, permease component I
 9 15 22 38 ---|--|-|-|----||-||-|-||||||-|||||||-  98 [E]  COG1177 ABC-type spermidine/putrescine transport system, permease component II
 9 14 20 30 ---|-|--|-|-----||||-||-||-||-|||||-|-  65 [P]  COG1178 ABC-type Fe3+ transport system, permease component
 4  8 13 23 -----------||------|---||--||||||||---  24 [H]  COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
 8 16 22 33 |||-|||||||---||---|--||||-||-|||-----  70 [O]  COG1180 Pyruvate-formate lyase-activating enzyme
11 16 24 46 --|-----------||||||||||||-|||||||||||  65 [M]  COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes
 3  7 10 21 ----------------|------||||||--||---|-  29 [I]  COG1182 Acyl carrier protein phosphodiesterase
 8 18 21 32 ||||--||---||------||||||--|-|--|||-||  39 [I]  COG1183 Phosphatidylserine synthase
 4 10 11 13 -||||||-|-|||--|----------------------  20 [J]  COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
11 17 25 48 -----------||-||||||||||||-|||||||||||  48 [J]  COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)
11 17 25 47 -----------||-||||||||||||-|||||||||||  66 [J]  COG1186 Protein chain release factor B
10 16 24 47 --------------||||||||||||||||||||||||  99 [J]  COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases
 5  9 15 31 ---------------|---|--||||-||-|||||||-  32 [J]  COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
 9 14 17 31 --|---|-------||||-|-||||||-------||||  31 [J]  COG1189 Predicted rRNA methylase
13 20 27 49 --|-----||-||||||||||-|||||||||||||-|-  59 [J]  COG1190 Lysyl-tRNA synthetase (class II)
 8 12 14 25 --------------||||--|||||--||-|-|-|---  45 [K]  COG1191 DNA-directed RNA polymerase specialized sigma subunit
10 21 28 48 ||-|||-|||----|-|||-|||||-|||||-|||||| 148 [D]  COG1192 ATPases involved in chromosome partitioning
 9 14 15 23 |-||-|--------||||||-|-|||--------|---  26 [L]  COG1193 Mismatch repair ATPase (MutS family)
 9 14 22 43 |--|----|-|-|-----|-||||||-||||||||||-  44 [L]  COG1194 A/G-specific DNA glycosylase
 9 12 19 36 --------|-------||||||||||-|||||---|||  36 [L]  COG1195 Recombinational DNA repair ATPase (RecF pathway)
12 23 26 44 -||||||----|||||||||-|||||||-|---|-||-  60 [D]  COG1196 Chromosome segregation ATPases
 9 14 22 45 ---------------|||||||||||-|||||||||||  45 [LK] COG1197 Transcription-repair coupling factor (superfamily II helicase)
10 15 23 46 --------------||||||||||||-|||||||||||  47 [L]  COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase
10 20 28 43 ||||||--|||||||-||-|--||||-|||||||-|--  61 [KL] COG1199 Rad3-related DNA helicases
 9 14 22 43 --------------||||||-|||||-|||||||||||  43 [LK] COG1200 RecG-like helicase
 5 14 18 27 |||||||||||-----|-----|----||---|--||-  38 [R]  COG1201 Lhr-like helicases
 1  6  6  7 ||||-|-|------------------------------   7 [R]  COG1202 Superfamily II helicase, archaea-specific
 7 11 15 20 |||--||-|||---||---|----||--|--|------  28 [R]  COG1203 Predicted helicases
 6 15 17 20 |||||||||||||||-------------|-------|-  26 [R]  COG1204 Superfamily II helicase
 8 15 16 21 |||--|||||-||---|-|---|-|---|-------|-  27 [R]  COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
 7  8 10 18 --------------||||||----||---------||-  18 [J]  COG1206 NAD(FAD)-utilizing enzyme possibly involved in translation
 8 13 21 42 --------------||||||--||||-|||||||||||  42 [M]  COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)
10 23 29 40 |||||||||||||||-|||---|||--|||--|||||-  90 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)
 8 17 23 37 |-|||||--||----||||---||||-|||--||-||-  48 [M]  COG1209 dTDP-glucose pyrophosphorylase
 9 17 24 44 |||--|---|----|-|--|-||||||||||||||||-  61 [M]  COG1210 UDP-glucose pyrophosphorylase
11 17 24 44 -----|--------|||||||||||||||||||||||-  46 [I]  COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase
 4  7 14 27 --------------|----||------|||||||||||  27 [M]  COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase
 5  9  9 10 |----||---|---|----|-------|------||--  11 [M]  COG1213 Predicted sugar nucleotidyltransferases
10 16 24 50 --------------||||||||||||||||||||||||  50 [O]  COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone
 9 19 24 37 |-|-||||||-||||-||----||||-||---|--|||  82 [M]  COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
 7 14 18 25 |-|-|||---|-----|||---||---|||-||--||-  54 [R]  COG1216 Predicted glycosyltransferases
 6 11 19 40 ----------------||||--||||-|||||||||||  40 [T]  COG1217 Predicted membrane GTPase involved in stress response
 6 10 16 30 -----------||-|-||--|-|----|||||--||||  31 [P]  COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase
11 16 24 47 -----------|--||||||||||||-|||||||||||  47 [O]  COG1219 ATP-dependent protease Clp, ATPase subunit
 5  8 14 29 --------------||-----|--|--||||||-||||  29 [O]  COG1220 ATP-dependent protease HslVU (ClpYQ), ATPase subunit
 4  7  9 14 ---------------|||-----||--||-|-|-----  28 [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
 4 11 12 13 ||||-|||-|||||------------------------  31 [O]  COG1222 ATP-dependent 26S proteasome regulatory subunit
 1  5  5  5 |||---||------------------------------   5 [R]  COG1223 Predicted ATPase (AAA+ superfamily)
 4  7  9 10 -----|||||||||------------------------  13 [K]  COG1224 DNA helicase TIP49, TBP-interacting protein
10 18 27 44 --|||---|||||-|||||---|||--|||||||||||  70 [O]  COG1225 Peroxiredoxin
10 23 32 50 ||||||||-|||--|||||---|||||||||||||||| 134 [P]  COG1226 Kef-type K+ transport systems, predicted NAD-binding component
 8 11 12 16 -|----|----|||-|--||---|||----|-------  17 [C]  COG1227 Inorganic pyrophosphatase/exopolyphosphatase
 9 16 20 28 |--||||--|-|---|--||--||||-||-|-|--||-  45 [Q]  COG1228 Imidazolonepropionase and related amidohydrolases
 1  5  5  5 |||---||------------------------------   7 [C]  COG1229 Formylmethanofuran dehydrogenase subunit A
11 17 24 37 --|--|--||-||||||-|---||||-|||-||||||-  47 [P]  COG1230 Co/Zn/Cd efflux system component
 5  8  9 11 ----------------|||---|-|--|----|--||-  12 [E]  COG1231 Monoamine oxidase
 9 15 15 22 --||-||-|--||-|---|-|-|-|---|---|--|--  22 [H]  COG1232 Protoporphyrinogen oxidase
 7 12 14 18 ||||-----||-----|||---|-|-------|--||-  53 [Q]  COG1233 Phytoene dehydrogenase and related proteins
12 24 29 44 ||||||||||||||-||||-||||||--|--||--||-  66 [R]  COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
 9 20 24 40 ||||||||----|-|-||-|||-|||-||---|--|||  55 [R]  COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
 7 16 20 23 -||||||-||||||--|||--------|--|-|--||-  37 [J]  COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing
 4  9  9 10 |||--|||-------|-------|----|---------  20 [R]  COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II
 3  8 15 25 -||----|------|------------|||||||||||  34 [S]  COG1238 Predicted membrane protein
 5 13 13 16 |||||-||--------|||---|----|----|-----  22 [H]  COG1239 Mg-chelatase subunit ChlI
 4 11 11 14 |||||--|--------||----|----|----|-----  15 [H]  COG1240 Mg-chelatase subunit ChlD
 4 12 14 16 ||||||||||||||------------------------  45 [L]  COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family
 6  8 10 18 -|-----|------||---|---|||--|-|-------  18 [R]  COG1242 Predicted Fe-S oxidoreductase
 7 15 16 18 ||||||||||-|||-|---|---|--------------  18 [KB] COG1243 Histone acetyltransferase
 2  9  9 11 ||||||||---------------|--------------  11 [R]  COG1244 Predicted Fe-S oxidoreductase
 4 12 14 16 ||||||||||||||------------------------  16 [R]  COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
 6  8 12 21 --||----------|---|---|-|--||-||||----  23 [E]  COG1246 N-acetylglutamate synthase and related acetyltransferases
 7 11 16 26 --|-----|-|-----|||---||||-||-|-|--||-  31 [M]  COG1247 Sortase and related acyltransferases
12 23 33 56 |||||-|||||||-|||||||-|-||||||||||-||| 162 [C]  COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
 7 12 18 31 ---||-|-|||-------||--|||--||-|-|--|||  93 [I]  COG1250 3-hydroxyacyl-CoA dehydrogenase
 5  8 10 19 --|-----------|-------|||--||---|--||-  24 [C]  COG1251 NAD(P)H-nitrite reductase
 8 12 16 29 ---|-----|-||---|||---|-||-||-|||---|-  55 [C]  COG1252 NADH dehydrogenase, FAD-containing subunit
12 20 28 52 --||-------||-|||||||||||||||||||||||| 103 [R]  COG1253 Hemolysins and related proteins containing CBS domains
 9 16 22 34 -||-|||-|||----||-|--|||||-||-|||---|-  42 [C]  COG1254 Acylphosphatases
 1  5  5  6 ||-|-||-------------------------------   6 [S]  COG1255 Uncharacterized protein conserved in archaea
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  26 [N]  COG1256 Flagellar hook-associated protein
 7 15 18 23 ||||||||||||||-------|--||----|-------  24 [I]  COG1257 Hydroxymethylglutaryl-CoA reductase
 3 10 12 14 |||||||||||--|------------------------  14 [J]  COG1258 Predicted pseudouridylate synthase
 7 10 12 16 --||--|-|||---||||--|-|---------------  16 [S]  COG1259 Uncharacterized conserved protein
 7 10 12 16 |-|--||-||||--||------|-------------|-  19 [I]  COG1260 Myo-inositol-1-phosphate synthase
 3  6  9 19 --------------||-----------||-|-|-|||-  20 [NO] COG1261 Flagellar basal body P-ring biosynthesis protein
 7 10 15 22 --|---------|---||--|-|-|--|-|||||-||-  39 [S]  COG1262 Uncharacterized conserved protein
 5  9 13 25 -------------------|-||||||||-|||--|-- 100 [G]  COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific
 5  9 13 26 -------------------|-||||||||-|||--|-- 107 [G]  COG1264 Phosphotransferase system IIB components
12 19 24 37 |-||-|--|-|---||||||||||||-||-|-|--||- 104 [R]  COG1266 Predicted metal-dependent membrane protease
 6 13 19 31 |||--|-||-|---|----|----||-||-|||||--|  33 [I]  COG1267 Phosphatidylglycerophosphatase A and related proteins
10 16 18 28 |-||-||--------|||||||||||----------||  34 [R]  COG1268 Uncharacterized conserved protein
 9 17 19 24 ||||||||||||||----||||---|------------  26 [C]  COG1269 Archaeal/vacuolar-type H+-ATPase subunit I
 8 19 23 30 |||||||||||-----||||--|||--||-|-|---|-  31 [H]  COG1270 Cobalamin biosynthesis protein CobD/CbiB
 7 14 20 36 --|||-|-------|-||--|-|-||-||-|||-||||  52 [C]  COG1271 Cytochrome bd-type quinol oxidase, subunit 1
 8 12 17 33 -----------|||----||-|||||-||||--|-||-  38 [R]  COG1272 Predicted membrane protein, hemolysin III homolog
 4  5  5  9 ------|---------------|-|--|--------|-  18 [S]  COG1273 Uncharacterized conserved protein
 6  7  7 13 ----||---|----------|||---------|-----  13 [C]  COG1274 Phosphoenolpyruvate carboxykinase (GTP)
 5 10 13 22 -|--|||----||---------|-||--|-||-|----  29 [P]  COG1275 Tellurite resistance protein and related permeases
 4  6  6 13 --------------|---|-----|---|---|---|-  13 [P]  COG1276 Putative copper export protein
 8 17 18 27 --|||||--||----||||--|-||-||----|---|-  64 [R]  COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
 8 11 19 37 ---|----------||--||--||||-|||||||-||| 127 [K]  COG1278 Cold shock proteins
 4  8 12 22 -------------------|--|||--||-|||-|-||  25 [R]  COG1279 Lysine efflux permease
 8 15 22 32 |-|-|-|||||----|-||---|-|--||||||-|||- 127 [E]  COG1280 Putative threonine efflux protein
 7 12 19 33 --------------||||||---|||||||||||-||-  34 [O]  COG1281 Disulfide bond chaperones of the HSP33 family
 3  6 12 24 ----------------||----|----||-||||-|||  26 [C]  COG1282 NAD/NADP transhydrogenase beta subunit
 5  8 11 21 -------------------|-||-|||||-|---|-|-  29 [P]  COG1283 Na+/phosphate symporter
 7 10 11 22 -------|-------|---|||-||||---|-----|-  50 [S]  COG1284 Uncharacterized conserved protein
 8 12 15 26 --------------|-||||-|||||-||--||---|-  33 [S]  COG1285 Uncharacterized membrane protein
 3  6 14 32 ---------------------|--||-|||||||||||  32 [R]  COG1286 Uncharacterized membrane protein, required for colicin V production
 4 11 12 14 |||||||-||-||---------------------|---  26 [R]  COG1287 Uncharacterized membrane protein, required for N-linked glycosylation
 4  5  7 13 -------------------|-|--||--|--|---|--  19 [S]  COG1288 Predicted membrane protein
 4  7 12 23 -----------------||-----|--||||||||-|-  55 [S]  COG1289 Predicted membrane protein
 9 14 21 33 ---||---||||--|-|||---|-|--|-||-||||||  45 [C]  COG1290 Cytochrome b subunit of the bc complex
 5  9 12 24 --------------||-----|-||--||-|-|-|||-  28 [N]  COG1291 Flagellar motor component
 5  7 10 21 ---|-----------------||-|--||-||-|--|-  37 [M]  COG1292 Choline-glycine betaine transporter
11 21 24 33 ||||||||||||||-|||||-|-|||--------|---  34 [K]  COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP
 7 12 18 33 --||----------|-||--|-|-||-||-|||-||||  46 [C]  COG1294 Cytochrome bd-type quinol oxidase, subunit 2
 9 15 23 44 --|-----------|-|||||-||||||||||||||||  63 [S]  COG1295 Predicted membrane protein
 6 10 15 29 --|---|-----------||--|-||-||-|||||-|-  35 [E]  COG1296 Predicted branched-chain amino acid permease (azaleucine resistance)
 4  8 11 13 ---|-|-----|----------|----|-|-|||||--  14 [S]  COG1297 Predicted membrane protein
 6 10 13 27 --------------||----||-||--||-|-|-|||-  31 [NU] COG1298 Flagellar biosynthesis pathway, component FlhA
 6  9 13 24 ------------------||-||||||||-|||-----  52 [G]  COG1299 Phosphotransferase system, fructose-specific IIC component
 6 14 15 19 |||--|||--|-----||----|||--|-------||-  23 [S]  COG1300 Uncharacterized membrane protein
11 17 22 36 --||-|----|---|-|-|||||||--||||-|-||||  69 [C]  COG1301 Na+/H+-dicarboxylate symporters
 5  6  7 13 ---------------|--|||--|||------------  29 [S]  COG1302 Uncharacterized protein conserved in bacteria
 2  9 10 12 ||||||||-||---------------------------  12 [S]  COG1303 Uncharacterized protein conserved in archaea
 9 20 28 48 |||||||||||||---|||--||-||-||-||-|-|||  71 [C]  COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
 9 17 21 29 |-|--|||||----|||||---|||--|-|-||--||-  74 [E]  COG1305 Transglutaminase-like enzymes, putative cysteine proteases
 2  2  2  3 -------------------|-|----------------   3 [S]  COG1306 Uncharacterized conserved protein
 6  8  9 19 ---------------|--||--||||||----------  43 [S]  COG1307 Uncharacterized protein conserved in bacteria
 4 12 13 15 |||||||||-||||------------------------  15 [K]  COG1308 Transcription factor homologous to NACalpha-BTF3
10 20 27 44 |-||-||--|----||||||--|||||||||||||||- 592 [K]  COG1309 Transcriptional regulator
 9 18 21 27 |-|||||||||||||-|||---|----||---|-----  56 [R]  COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily
 3 11 11 13 ||||||||---|||------------------------  13 [L]  COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
 4  6  8 17 ----|----------|-------|||--|--|----|-  20 [G]  COG1312 D-mannonate dehydratase
 5 10 11 12 |||--||||-|---||-------|--------------  13 [R]  COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins
 9 15 23 47 --------------|-||||||||||||||||||||||  47 [U]  COG1314 Preprotein translocase subunit SecG
 4  5  5  6 ---------------|-----|-||-----|-------   6 [L]  COG1315 Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain
 6  8  9 18 ---------------||||--|||||------------  46 [K]  COG1316 Transcriptional regulator
 5  9 11 21 ---------------|----||-||--||-|-|-|-|-  25 [NU] COG1317 Flagellar biosynthesis/type III secretory pathway protein
 4  7  8  9 -|---||||-|---||----------------------  10 [K]  COG1318 Predicted transcriptional regulators
 6  8 11 18 --------|||-------|--||-|--||---|---|-  38 [C]  COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs
 6 11 13 20 ||||-|---------|--|---|-|--|--|-----||  29 [P]  COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit
 9 18 22 36 |||||||||||----|--|-||||||--||------|-  55 [K]  COG1321 Mn-dependent transcriptional regulator
 3  6 13 26 --------------------|----|||||||||-|||  26 [S]  COG1322 Uncharacterized protein conserved in bacteria
 4  8  9 14 ||-----|-------|---|---||||-----------  16 [R]  COG1323 Predicted nucleotidyltransferase
 9 16 18 25 |-|-|||||-|--||||-|-|-------||--|----|  25 [P]  COG1324 Uncharacterized protein involved in tolerance to divalent cations
 2  8 10 11 ||||-||||||---------------------------  12 [J]  COG1325 Predicted exosome subunit
 1  7  7  8 ||||-|||------------------------------   9 [R]  COG1326 Uncharacterized archaeal Zn-finger protein
 8 11 18 36 ---------------|-||||-||||-|||||||-||-  36 [K]  COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains
 5 11 15 24 |||--|-|-------|---|---|||-||-|||-----  27 [F]  COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase
 5  5  7 16 ------------------|--||-|----------|||  17 [K]  COG1329 Transcriptional regulators, similar to M. xanthus CarD
 4  5  9 18 --------------------|||----|||||-|----  18 [L]  COG1330 Exonuclease V gamma subunit
 9 14 16 20 |-|||-|-|||---|-|-|-|-|||-----------|-  24 [O]  COG1331 Highly conserved protein containing a thioredoxin domain
 3  7  7  8 |||-||---------|------|---------------   8 [L]  COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 5  6  7 12 --------------|-||----|-|-------||----  12 [O]  COG1333 ResB protein required for cytochrome c biosynthesis
 4  6  7 10 --------------||-------||--|--|---|---  10 [N]  COG1334 Uncharacterized flagellar protein FlaG
11 21 29 47 --|||||||||||-|||-|--|||||-||||-|||||- 126 [Q]  COG1335 Amidases related to nicotinamidase
 5  7  7  7 |-----||-|----||--------|-------------  11 [L]  COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 5 10 11 12 |||-||-|||-----||-----|---------------  17 [L]  COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 6 10 13 27 --------------||----||-||--||-|-|-|||-  29 [NU] COG1338 Flagellar biosynthesis pathway, component FliP
 2  9 11 13 |||||||||||---------------------------  13 [KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon
 2  8 10 12 |-|||||||||---------------------------  13 [S]  COG1340 Uncharacterized archaeal coiled-coil protein
 3  7  9 10 -|---||||||||-------------------------  12 [R]  COG1341 Predicted GTPase or GTP-binding protein
 3  7  7  8 |||--||----------------|------|-------  10 [R]  COG1342 Predicted DNA-binding proteins
 7 12 14 15 |||-|-||||-----||--|--|-||------------  18 [L]  COG1343 Uncharacterized protein predicted to be involved in DNA repair
 5  9 12 24 --------------||-----|-||--||-|-|-|||-  81 [N]  COG1344 Flagellin and related hook-associated proteins
 5  8 10 19 --------------||-----|-||--||-|-|-|---  20 [N]  COG1345 Flagellar capping protein
 5  9 14 23 --|--|------------||---|||-||-||||--|-  30 [M]  COG1346 Putative effector of murein hydrolase
 2  3  6  9 --------------------|------||-||-|----   9 [C]  COG1347 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD
 5  9  9 10 |||----|--------||-|---|------------|-  18 [P]  COG1348 Nitrogenase subunit NifH (ATPase)
 7 10 15 29 --------------||--||--||||-||-||||--|- 145 [KG] COG1349 Transcriptional regulators of sugar metabolism
 4  8 10 12 |-|-|||-|||---||----------------------  15 [R]  COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)
10 14 16 26 ---|||--|||---||||--||||----------|--|  26 [F]  COG1351 Predicted alternative thymidylate synthase
 6 13 16 26 --||-||--------||----|-||--||-|-|-|||-  44 [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins
 6 12 13 14 |||-||||||----||------|-|-------------  18 [R]  COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs)
10 20 24 41 -||||||-------||||||-|||||||-|--||-||-  42 [S]  COG1354 Uncharacterized conserved protein
 6 13 15 17 |||-|||||||||-||--------------------|-  18 [R]  COG1355 Predicted dioxygenase
 1  4  4  5 ||-|-|--------------------------------   5 [S]  COG1356 Uncharacterized protein conserved in archaea
 7 11 16 27 --||------------|||--|||||-||--|---||| 105 [S]  COG1357 Uncharacterized low-complexity proteins
 7 16 19 26 ||||||||||||||-|---|---|||------------  41 [J]  COG1358 Ribosomal protein HS6-type (S12/L30/L7a)
 7 11 17 28 --||-------------|||--||||-||-||||-||-  56 [S]  COG1359 Uncharacterized conserved protein
 5  9 12 24 --------------||-----|-||--||-|-|-|||-  45 [N]  COG1360 Flagellar motor protein
 3  8  9 11 -||||||-||-----|----------------------  31 [M]  COG1361 S-layer domain
 7  8  8 11 -----------||--|---|-|||---|----------  14 [E]  COG1362 Aspartyl aminopeptidase
 8 17 20 30 ||||-||||-|----||-||---||||||-------|-  56 [G]  COG1363 Cellulase M and related proteins
 9 18 21 31 |||---||---||-|||||---||||-|----||-||-  33 [E]  COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase)
 1  4  4  5 ||---|-|------------------------------   5 [R]  COG1365 Predicted ATPase (PP-loop superfamily)
 9 12 14 20 ---------------||||||||||--|--|----||-  69 [T]  COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
 4  4  4  4 ------|-------||--------|-------------   4 [L]  COG1367 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 3  7 11 23 ---------------|-------|||-||-||-||-|-  36 [M]  COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
 3 10 11 12 ||||-|||-||||-------------------------  12 [J]  COG1369 RNase P/RNase MRP subunit POP5
 2  9 11 13 |||||||||||---------------------------  13 [O]  COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit
 5 12 14 17 |||||||||||---||------|---------------  17 [S]  COG1371 Uncharacterized conserved protein
 8 12 12 16 -|--||-|--||--|-|||---|-|-------------  77 [L]  COG1372 Intein/homing endonuclease
 7 12 15 19 -||-||--||-----|---|--|-||-----|--|-||  53 [R]  COG1373 Predicted ATPase (AAA+ superfamily)
 4  8  8  9 -|---|||--||||------------------------   9 [J]  COG1374 Protein involved in ribosomal biogenesis, contains PUA domain
 5  9 12 23 ---------------|||----|||--||-|-||--|-  94 [S]  COG1376 Uncharacterized protein conserved in bacteria
 6 10 13 27 --------------||----||-||--||-|-|-|||-  32 [NU] COG1377 Flagellar biosynthesis pathway, component FlhB
 4 11 13 15 |||||||||||-------|-----|-------------  36 [K]  COG1378 Predicted transcriptional regulators
 2  6  6  8 |||--|-|----------------|-------------   9 [S]  COG1379 Uncharacterized conserved protein
 5  9 14 23 --|--|------------||---|||-||-||||--|-  30 [R]  COG1380 Putative effector of murein hydrolase LrgA
 8 13 21 41 ----------------||||||||||||||||||-|||  41 [L]  COG1381 Recombinational DNA repair protein (RecF pathway)
 3 11 13 15 |||||||||||||-------------------------  17 [O]  COG1382 Prefoldin, chaperonin cofactor
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG1383 Ribosomal protein S17E
 4 11 13 18 ||||||||--|----------|-------------|||  18 [J]  COG1384 Lysyl-tRNA synthetase (class I)
 9 15 23 46 --------------||||||-|||||||||||||||||  49 [S]  COG1385 Uncharacterized protein conserved in bacteria
 9 17 21 38 --|-|||--------|||||-|||||||-|--||-||-  43 [K]  COG1386 Predicted transcriptional regulator containing the HTH domain
 9 18 20 30 |||-||||---||-||--||--||||--|-|-----|-  40 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family
 7  8 12 19 --------------|---|-||||||-||-||------  43 [M]  COG1388 FOG: LysM repeat
 2  8 10 11 ||||-||||||---------------------------  11 [L]  COG1389 DNA topoisomerase VI, subunit B
 8 16 17 21 |||||||||-||||----||||----------------  21 [C]  COG1390 Archaeal/vacuolar-type H+-ATPase subunit E
 3  5 10 22 --------------|-------|----||-||||-||-  22 [OT] COG1391 Glutamine synthetase adenylyltransferase
 7 14 16 23 |||--||--|-----|--|-|--||--|--|||---|-  28 [P]  COG1392 Phosphate transport regulator (distant homolog of PhoU)
 6 11 18 35 ----------------|-||--|||||||||||||||-  75 [P]  COG1393 Arsenate reductase and related proteins, glutaredoxin family
 9 17 19 24 ||||||||||||||----||||---|------------  25 [C]  COG1394 Archaeal/vacuolar-type H+-ATPase subunit D
 2  9 11 13 |||||||||||---------------------------  13 [K]  COG1395 Predicted transcriptional regulator
11 15 23 40 |-|-----|-----|||-||-|||||-|||||||-||| 387 [K]  COG1396 Predicted transcriptional regulators
 6 10 10 13 -||---|-------|-|-|----|-|--|-------|-  15 [O]  COG1397 ADP-ribosylglycohydrolase
 3  7  7  8 -----------||---||---------|----|----|  10 [I]  COG1398 Fatty-acid desaturase
 7 10 16 30 --------------|||||---||||-|||||||----  30 [R]  COG1399 Predicted metal-binding, possibly nucleic acid-binding protein
 4 12 14 16 ||||||||||||||------------------------  16 [U]  COG1400 Signal recognition particle 19 kDa protein
 7 10 12 15 |-|--|--||----|--||-----||--|-----|---  16 [V]  COG1401 GTPase subunit of restriction endonuclease
 7 11 14 19 ||-|---||||----|||----|-|----------||-  24 [R]  COG1402 Uncharacterized protein, putative amidase
 6 10 14 24 ---|------------|||---||||--|||-|--||-  58 [V]  COG1403 Restriction endonuclease
11 20 26 35 --||--|-|-|||||-||||--|||||||||-|||-|- 105 [O]  COG1404 Subtilisin-like serine proteases
 4 12 14 16 ||||||||||||||------------------------  39 [K]  COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
 4  5  5  6 ---------------|-----|-||-----|-------   6 [N]  COG1406 Predicted inhibitor of MCP methylation, homolog of CheC
 3 10 13 18 |||||||||||------------------------||-  22 [R]  COG1407 Predicted ICC-like phosphoesterases
 9 14 15 24 |-|-----|-----|-|-|-|-||||--|---|-|-|-  30 [R]  COG1408 Predicted phosphohydrolases
 9 18 24 39 |-|--||||-|||-|-||--|-||||-||-|||--||-  75 [R]  COG1409 Predicted phosphohydrolases
 6 10 15 25 ---------------||||---|||--||||||--||-  28 [E]  COG1410 Methionine synthase I, cobalamin-binding domain
 1  5  5  5 |||---||------------------------------   5 [R]  COG1411 Uncharacterized protein related to proFAR isomerase (HisA)
 4 12 14 16 ||||||||||||||------------------------  19 [R]  COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
 8 13 14 19 |-||-------|||--||--||--|--||-------|-  54 [C]  COG1413 FOG: HEAT repeat
 7 10 14 25 ---|----------||--|---|-|--||-|||-|||-  99 [K]  COG1414 Transcriptional regulator
 3  7  9 12 |---|||||||-------------------------|-  13 [S]  COG1415 Uncharacterized conserved protein
 4  8  8  9 |--||-|-------|---|-------------|---|-  10 [S]  COG1416 Uncharacterized conserved protein
 1  4  4  4 ||----||------------------------------   9 [S]  COG1417 Uncharacterized conserved protein
 8 19 20 36 ||||||||------||--||-|-||||-|-----|-|-  51 [R]  COG1418 Predicted HD superfamily hydrolase
 5  8  9 14 --------------||-----|-||--|--|-|-|---  14 [N]  COG1419 Flagellar GTP-binding protein
 7 13 15 32 ---------------|||-||-|||||--|--|-|||-  32 [K]  COG1420 Transcriptional regulator of heat shock gene
 2  6  6  6 ||--||-|-------|----------------------   6 [L]  COG1421 Uncharacterized protein predicted to be involved in DNA repair
 1  8  8 10 ||||||||------------------------------  11 [S]  COG1422 Predicted membrane protein
 3  8  8  9 |||--|||--|---|-----------------------   9 [L]  COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III
 3  3  3  4 -|------------|---------|-------------   4 [H]  COG1424 Pimeloyl-CoA synthetase
 6  8 13 26 ---------------||---||--||-||||||----|  27 [S]  COG1426 Uncharacterized protein conserved in bacteria
 7  8  9 13 ----|-|-|-|---|---|-|---|---------|---  13 [R]  COG1427 Predicted periplasmic solute-binding protein
 4  5  6 12 ------------------|--|--|||-----|-----  16 [F]  COG1428 Deoxynucleoside kinases
 4 11 11 15 ||||---|--------||----|----|----|---|-  48 [H]  COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases
 6 13 14 19 ||-|-|-||------|||---|-------|--|--||-  21 [S]  COG1430 Uncharacterized conserved protein
 2  4  4  4 -|----||------|-----------------------   4 [J]  COG1431 Uncharacterized protein containing piwi/argonaute domain
 7 17 19 25 ||||-|||------|-|||--||----|--|--||||-  41 [S]  COG1432 Uncharacterized conserved protein
 5 11 11 13 |||-|||||------|-------|------|-------  28 [S]  COG1433 Uncharacterized conserved protein
 7 11 19 30 --------------|||||---||||-|||||||-|||  58 [S]  COG1434 Uncharacterized conserved protein
 8 12 15 30 ---||---|----|-|--|--|-||||-|-||----|-  30 [F]  COG1435 Thymidine kinase
 8 16 18 20 ||||||||||||||----||-|---|------------  20 [C]  COG1436 Archaeal/vacuolar-type H+-ATPase subunit F
 5 12 14 15 ||||-||||||----------|-|----|---|-----  17 [F]  COG1437 Adenylate cyclase, class 2 (thermophilic)
 6  7 10 23 ---------------|--|-|-||||--|-||------  30 [K]  COG1438 Arginine repressor
 4 12 14 16 ||||||||||||||------------------------  16 [R]  COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
 3  4  6 14 ---------------------|-|||--|-|-------  28 [G]  COG1440 Phosphotransferase system cellobiose-specific component IIB
 1  1  3  8 ----------------------------|-||------   8 [H]  COG1441 O-succinylbenzoate synthase
 2  4  7 13 ------------------------||--|--|--|-||  30 [M]  COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases
 5  6  6 11 ---|-------|||--------|-----|---------  11 [I]  COG1443 Isopentenyldiphosphate isomerase
 5  9 13 19 ---|-|||||||||--------------|-||------  23 [R]  COG1444 Predicted P-loop ATPase fused to an acetyltransferase
 6  9 13 25 ------------------||-||||||||-|||-----  55 [G]  COG1445 Phosphotransferase system fructose-specific component IIB
 5 10 13 18 ---|||--||--|---||----------|-|-|--||-  21 [E]  COG1446 Asparaginase
 3  4  6 15 ---------------------|-|||--|-|-------  31 [G]  COG1447 Phosphotransferase system cellobiose-specific component IIA
 4  7 12 20 -----------||------||------|||||||--|-  31 [E]  COG1448 Aspartate/tyrosine/aromatic aminotransferase
 5  9 10 12 -||-||--||----|-||---|----------------  19 [G]  COG1449 Alpha-amylase/alpha-mannosidase
 4  7 11 16 --------------|----||------||||-|-|||-  30 [NU] COG1450 Type II secretory pathway, component PulD
 7 16 22 34 ||||-||-------|---||--||--|||||-||||||  43 [R]  COG1451 Predicted metal-dependent hydrolase
 3  6 13 26 --------------|------|-----|||||||||||  27 [M]  COG1452 Organic solvent tolerance protein OstA
 4  6  6  6 |-|------------|||-----|--------------  16 [R]  COG1453 Predicted oxidoreductases of the aldo/keto reductase family
 9 18 23 36 |-|||||--||||-||---|--||||-||-|||---|-  73 [C]  COG1454 Alcohol dehydrogenase, class IV
 3  4  6 15 ---------------------|-|||--|-|-------  37 [G]  COG1455 Phosphotransferase system cellobiose-specific component IIC
 1  5  5  5 |||---||------------------------------   6 [C]  COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)
 5  7  9 17 ----||---|-|------------|--||--|-|----  24 [F]  COG1457 Purine-cytosine permease and related proteins
 3  8  8  9 |||--|||--|---|-----------------------   9 [R]  COG1458 Predicted DNA-binding protein containing PIN domain
 8 12 19 31 --------------|||||||--|||-|||||||-||-  45 [NU] COG1459 Type II secretory pathway, component PulF
 2  9 11 13 |||||||||||---------------------------  13 [S]  COG1460 DNA-directed RNA polymerase, subunit F
 5  7  8 18 ---------------|--||--|||||-----------  22 [R]  COG1461 Predicted kinase related to dihydroxyacetone kinase
 4  7  9 14 --------------|-|||--------||---||-|--  16 [M]  COG1462 Uncharacterized protein involved in formation of curli polymers
 4  8 15 29 --------------|-||----|----|||||||||||  87 [Q]  COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component
 7 11 18 34 ------------------||||||||-||||||||||-  53 [P]  COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen
 2  7  7  7 ||||--||------|-----------------------   7 [E]  COG1465 Predicted alternative 3-dehydroquinate synthase
 9 15 23 49 --------------|||||-||||||||||||||||||  50 [L]  COG1466 DNA polymerase III, delta subunit
 4 12 14 16 ||||||||||||||------------------------  17 [L]  COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit
 7 11 14 15 |||--||-|||---|||--|----||------------  23 [L]  COG1468 RecB family exonuclease
 5 13 15 20 ||||||||--|----|--------|--|-|--||----  20 [S]  COG1469 Uncharacterized conserved protein
 2  4  4  5 --|--||-----------------|-------------   6 [S]  COG1470 Predicted membrane protein
 4 12 14 16 ||||||||||||||------------------------  19 [J]  COG1471 Ribosomal protein S4E
 9 13 21 36 ---------|--|--||||--|||||-|||||||-|||  62 [G]  COG1472 Beta-glucosidase-related glycosidases
 9 17 21 35 --||||---|-----|||||--||||-||--||-|||-  89 [R]  COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase
 4 10 12 14 |-|||||-||||||------------------------  41 [LO] COG1474 Cdc6-related protein, AAA superfamily ATPase
10 18 27 49 ||-|-||-|||---|-|-|-||||||-||||-|||||| 111 [K]  COG1475 Predicted transcriptional regulators
 5 12 13 18 ||||-||---------|-|----|||-|-------|--  34 [K]  COG1476 Predicted transcriptional regulators
 9 12 19 30 --|-----------||--||||-|||-|||||||-||-  35 [H]  COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis
 4  9  9 12 ||||--||------------|-|--|------------  13 [S]  COG1478 Uncharacterized conserved protein
 7 14 16 21 -|||-|---------||--|--|||-|-|-||-||---  58 [S]  COG1479 Uncharacterized conserved protein
 6  8  8 10 ---------------|||-|||-||-------------  10 [R]  COG1480 Predicted membrane-associated HD superfamily hydrolase
 4  6  7 18 ---------------|---|--|||||-----------  18 [S]  COG1481 Uncharacterized protein conserved in bacteria
 8 11 14 26 ------|----||--|--|--||||||-|-||------  30 [G]  COG1482 Phosphomannose isomerase
 4  6  6  7 -----|||--|----|--------------------|-   9 [R]  COG1483 Predicted ATPase (AAA+ superfamily)
 5  9 10 23 --|-----------|-------|||||-|---|---|- 125 [L]  COG1484 DNA replication protein
 4  7 13 23 -----------||-----|---|----||||-||-|||  25 [R]  COG1485 Predicted ATPase
 3  5  6 14 ---------------|-------||---|-|-----|-  37 [G]  COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
 6 12 17 21 -||--||-||------|||---|-----||-||--|||  84 [R]  COG1487 Predicted nucleic acid-binding protein, contains PIN domain
12 24 32 54 --|||||||||||-||||||-||||||||||||||-|-  60 [H]  COG1488 Nicotinic acid phosphoribosyltransferase
 7 12 18 26 |---|-|-|||---||||-----||--||-||---||-  26 [R]  COG1489 DNA-binding protein, stimulates sugar fermentation
 8 11 16 29 -----------||-||--||--||||-||-||||----  29 [J]  COG1490 D-Tyr-tRNAtyr deacylase
 2  9 11 13 |||||||||||---------------------------  13 [J]  COG1491 Predicted RNA-binding protein
 8 18 21 27 |||||-||-|------||||--|||--||-|-|--||-  31 [H]  COG1492 Cobyric acid synthase
 5  9 12 24 -------|-----------|-|-||||--|--||-||-  24 [T]  COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism
 7 10 13 22 --|-------------||||--|||---|-||---||-  26 [G]  COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins
 4  7 14 28 ------------------|-|---|--|||||||||||  35 [O]  COG1495 Disulfide bond formation protein DsbB
 9 14 21 37 --------------|-|||||||||--|||||||||||  39 [S]  COG1496 Uncharacterized conserved protein
 1  7  7  8 |||||-||------------------------------   8 [K]  COG1497 Predicted transcriptional regulator
 4 12 14 16 ||||||||||||||------------------------  21 [J]  COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog
 4 12 14 16 ||||||||||||||------------------------  17 [J]  COG1499 NMD protein affecting ribosome stability and mRNA decay
 4 12 14 16 ||||||||||||||------------------------  16 [J]  COG1500 Predicted exosome subunit
 7 11 14 21 ----|---||-||--||------|||--|---|--||-  37 [G]  COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases
11 19 27 47 ----|-|-|--|||-|||-||-|||||||||||||||| 104 [I]  COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes
 5 13 15 17 |||||||||||||||-----------------------  20 [J]  COG1503 Peptide chain release factor 1 (eRF1)
 1  5  5  6 |-|--|||------------------------------   7 [S]  COG1504 Uncharacterized conserved protein
 5  6  8 13 -----|----------|-|---|----------|-|||  17 [E]  COG1505 Serine proteases of the peptidase family S9A
 8 12 17 21 ---|||--|||||----|||----|--|-|-----|||  48 [E]  COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases
 3  3  3  6 --------------||------|---------------   6 [S]  COG1507 Uncharacterized conserved protein
 5  9 14 28 --------------|-----||-||--||||-|||||-  30 [K]  COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
 8 10 14 22 -||-----------||--||-|--|---||||---||-  25 [E]  COG1509 Lysine 2,3-aminomutase
 3  5  5  8 -|---|------------------|-------|---|-  11 [K]  COG1510 Predicted transcriptional regulators
 4  5  6 14 |-----------------|---||||------------  27 [S]  COG1511 Predicted membrane protein
 5  8 12 16 ---------------|||---|--||-||--||--||-  23 [R]  COG1512 Beta-propeller domains of methanol dehydrogenase type
 3  5  6  8 --------------|-||---------||---|-----   8 [P]  COG1513 Cyanate lyase
 9 18 22 33 |||-|||||||---|||-|---|||--||---|--||-  38 [J]  COG1514 2'-5' RNA ligase
 9 14 17 23 ---||||||||-|-|||-|----||---||--------  23 [L]  COG1515 Deoxyinosine 3'endonuclease (endonuclease V)
 5  8 10 19 --------------||-----|-||--||-|-|-|---  21 [NUO] COG1516 Flagellin-specific chaperone FliS
 3  5  6  6 -|--||--||----|-----------------------  12 [L]  COG1517 Uncharacterized protein predicted to be involved in DNA repair
 9 17 21 28 |||-|||||||---|||--|--|-||--|--|-||---  36 [L]  COG1518 Uncharacterized protein predicted to be involved in DNA repair
 4  7 14 27 --------------|----||------|||||||||||  27 [M]  COG1519 3-deoxy-D-manno-octulosonic-acid transferase
 7 14 18 26 ||||-||--------|--|--||-|--||||-|--|-|  66 [S]  COG1520 FOG: WD40-like repeat
 9 15 17 25 --------------||||||-||||-||-|--||||--  25 [K]  COG1521 Putative transcriptional regulator, homolog of Bvg accessory factor
 6 16 23 37 |||||||||||-------|---|||--||-||||-||- 250 [K]  COG1522 Transcriptional regulators
10 14 18 30 --|------|-----|-||||-|||||||-|||---|-  36 [G]  COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
 9 15 17 21 ----|||--|-|||-||-----|||--|-|----|||-  34 [R]  COG1524 Uncharacterized proteins of the AP superfamily
 7 16 17 26 ||-|-|-|---||-|-|-----|-|-||---|-||-|-  50 [L]  COG1525 Micrococcal nuclease (thermonuclease) homologs
 5 12 17 31 |||-|-|-||------------|-|--||-|||-|||-  32 [C]  COG1526 Uncharacterized protein required for formate dehydrogenase activity
 7 15 15 18 |||||||||--|||----||-----|------------  18 [C]  COG1527 Archaeal/vacuolar-type H+-ATPase subunit C
 6 11 13 23 |-|---|------|-|------|||-|-|-||--|---  29 [P]  COG1528 Ferritin-like protein
 7  9 13 19 --------|||---|---|--||-|--||---|--||-  60 [C]  COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs
10 16 25 42 ---|-|-||||---||||-||-|||--|||||||-|||  56 [J]  COG1530 Ribonucleases G and E
 2  6  8  8 ||---||||||---------------------------   8 [S]  COG1531 Uncharacterized protein conserved in archaea
 1  4  4  4 ||----||------------------------------   4 [R]  COG1532 Predicted RNA-binding protein
 8 16 20 26 -||-|||||||----|-|-|--|||--|----|--|||  36 [L]  COG1533 DNA repair photolyase
 5 13 20 32 ||||-|||-||--------|---|||-|||||||----  32 [J]  COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
 3  4  6  9 ---------------|--------|--||-|-----|-  10 [Q]  COG1535 Isochorismate hydrolase
 6 10 13 27 --------------||----||-||--||-|-|-|||-  30 [N]  COG1536 Flagellar motor switch protein
 4 12 14 16 ||||||||||||||------------------------  18 [R]  COG1537 Predicted RNA-binding proteins
 4  8 15 27 --------------|-||-|-------||||||||||| 113 [MU] COG1538 Outer membrane protein
 8 14 21 41 -----------||---|||||-||||-||||||||||-  47 [H]  COG1539 Dihydroneopterin aldolase
 6  9 13 22 -----|------------||--|-|--||-|||||-|-  26 [R]  COG1540 Uncharacterized proteins, homologs of lactam utilization protein B
 7 10 12 13 |-|---|--|------|-||----|---|||-|-----  23 [H]  COG1541 Coenzyme F390 synthetase
 3  4  4  4 -|-----|------||----------------------   4 [S]  COG1542 Uncharacterized conserved protein
 5  7  7 10 -----|----------||---||||-------------  11 [S]  COG1543 Uncharacterized conserved protein
10 14 21 38 --------------||||||||||||-||||||--|||  43 [J]  COG1544 Ribosome-associated protein Y (PSrp-1)
 4 11 13 16 |||||||||||-----------|------------|--  48 [R]  COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon
 9 15 21 40 ---|----------||||||--|||||||||-|||||-  46 [R]  COG1546 Uncharacterized protein (competence- and mitomycin-induced)
 6  8 10 13 ---||---|||---|-|||-----|-------------  13 [S]  COG1547 Uncharacterized conserved protein
 1  5  5  5 |||---||------------------------------   5 [KG] COG1548 Predicted transcriptional regulator/sugar kinase
 2  9  9 11 ||||||||-|----------------------------  12 [J]  COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain
 4  5  5  9 ---------------|--|---|||-------------   9 [S]  COG1550 Uncharacterized protein conserved in bacteria
 4  6 10 20 ---------------|-----|-||--|||||--|---  20 [T]  COG1551 Carbon storage regulator (could also regulate swarming and quorum sensing)
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG1552 Ribosomal protein L40E
 3  6  9 15 |||----|-------|-----------||-||------  21 [P]  COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction
 6  9 10 16 -----|-----|----|-----|||||-|----|----  22 [G]  COG1554 Trehalose and maltose hydrolases (possible phosphorylases)
 8 12 18 31 --|------------|||||--||||-||||||||---  40 [L]  COG1555 DNA uptake protein and related DNA-binding proteins
 5  8 11 17 ---|--|-----------||----||--|--||||---  17 [S]  COG1556 Uncharacterized conserved protein
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  26 [N]  COG1558 Flagellar basal body rod protein
 7 11 19 39 --------------|---||-|||||-|||||||||||  39 [R]  COG1559 Predicted periplasmic solute-binding protein
 4  7 14 30 -------------------||-|----|||||||||||  48 [M]  COG1560 Lauroyl/myristoyl acyltransferase
 6  9 15 26 --------------||---|-|-||--|||||||-||-  27 [S]  COG1561 Uncharacterized stress-induced protein
 8 13 15 22 |--|-----|-||---|||---|-|----|--||-||-  30 [I]  COG1562 Phytoene/squalene synthetase
 4  7  7  8 ||---|---------|||-------------------|   9 [P]  COG1563 Predicted subunit of the Multisubunit Na+/H+ antiporter
 7 10 11 19 -----------||--|--||-|-|||--------|-|-  19 [H]  COG1564 Thiamine pyrophosphokinase
 3  7 10 17 --------------|-||-----------|--||||||  17 [S]  COG1565 Uncharacterized conserved protein
 3  5 11 21 --------------|---------|--||-||||-|||  66 [V]  COG1566 Multidrug resistance efflux pump
 3  7  7  8 |||-||---------|------|---------------   8 [L]  COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 2  4  4  5 -|---||-------|-----------------------   6 [R]  COG1568 Predicted methyltransferases
 3  6  6  7 -|---||---------||-----------|--------  10 [R]  COG1569 Predicted nucleic acid-binding protein, contains PIN domain
 8 12 20 41 ---------------||-|||-||||-|||||||||||  42 [L]  COG1570 Exonuclease VII, large subunit
 2  9 11 13 |||||||||||---------------------------  17 [R]  COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
 2  5  5  6 |-|--||---------|---------------------   9 [S]  COG1572 Uncharacterized conserved protein
11 20 26 39 --|||||-|||---||||||-|||-|----||||||||  59 [L]  COG1573 Uracil-DNA glycosylase
 9 14 16 24 --||||----|---||--||--|-|--||---|--||-  33 [R]