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11 22 30 48 |||||-|||||-|-|-|||||-|||--||||||||||-  61 [H]  COG0001 Glutamate-1-semialdehyde aminotransferase
10 21 30 46 |||--||||||||-|||||---||||-||||||||||-  48 [E]  COG0002 Acetylglutamate semialdehyde dehydrogenase
 8 15 16 20 ||-|||-||-|||-|-||-|--|-|-------------  34 [P]  COG0003 Oxyanion-translocating ATPase
10 21 26 40 |||-|-||-|-||-|||||---||||||||--||-||-  58 [P]  COG0004 Ammonia permease
 9 20 25 36 |||||||||||||-||||----||||-|||------|-  46 [F]  COG0005 Purine nucleoside phosphorylase
14 28 38 65 |||||||||||||||||||||||||||||||||||||| 131 [E]  COG0006 Xaa-Pro aminopeptidase
10 21 28 44 |||||-|||||||-|-||||--|||--||||-||-||-  67 [H]  COG0007 Uroporphyrinogen-III methylase
14 28 38 66 |||||||||||||||||||||||||||||||||||||| 111 [J]  COG0008 Glutamyl- and glutaminyl-tRNA synthetases
14 27 37 63 ||||||||||||||||||||||||||||||||||-|||  82 [J]  COG0009 Putative translation factor (SUA5)
 8 21 29 41 |||||||||||||---||||---|||-||||||||-|-  78 [E]  COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family
 8 15 16 22 ||-||||||--|--||-|----||||------------  25 [S]  COG0011 Uncharacterized conserved protein
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0012 Predicted GTPase, probable translation factor
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  66 [J]  COG0013 Alanyl-tRNA synthetase
10 16 23 39 --|--------||-|||||--|||||-||||||||||-  41 [E]  COG0014 Gamma-glutamyl phosphate reductase
11 24 32 54 ||||||||||-||-||||||--||||-||||||||||-  67 [F]  COG0015 Adenylosuccinate lyase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0016 Phenylalanyl-tRNA synthetase alpha subunit
10 21 27 44 ||||||||||||||--||||-|-||||-||||------  63 [J]  COG0017 Aspartyl/asparaginyl-tRNA synthetases
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0018 Arginyl-tRNA synthetase
 9 20 27 47 |||-|-||---||-|||||---||||-||||||||||-  76 [E]  COG0019 Diaminopimelate decarboxylase
14 27 37 62 ||||||||||||||||||||||||||-|||||||||||  76 [I]  COG0020 Undecaprenyl pyrophosphate synthase
11 18 25 49 -----------||||||||-|||||||||||||||||-  62 [G]  COG0021 Transketolase
10 16 21 35 ---||---||||||--|||-|-|-||||----|--|||  56 [C]  COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
 5 14 19 26 |||||||||||||---||---------||-||------  29 [J]  COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins
14 27 37 65 |||||||||||||||||||||||-||||||||||||||  82 [J]  COG0024 Methionine aminopeptidase
 8 18 23 34 ||||||||---|||--|||---|-||-|||||----|-  56 [P]  COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
10 15 23 41 ---||---||-||-|||||---|-||-|||||||-||-  41 [F]  COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)
 6  8 11 18 -|---|---|------||----|-|--||-||------  18 [F]  COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)
10 22 31 49 |||-|||||||||-|||||---||||-||||||||||- 146 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
 8 13 18 30 ---|-|---|----|-||-|--|||--||||-||-||-  32 [H]  COG0029 Aspartate oxidase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  75 [J]  COG0030 Dimethyladenosine transferase (rRNA methylation)
11 20 29 50 --||||--|||||-||||||--||||-||||||||||- 103 [E]  COG0031 Cysteine synthase
 5  7  9 18 -----------||----||---|-----|-|----||-  19 [G]  COG0033 Phosphoglucomutase
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  53 [F]  COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase
12 21 29 48 |--|-|--|||||-||||||-||||||||-|||||||-  52 [F]  COG0035 Uracil phosphoribosyltransferase
13 21 28 53 -|--|------||||||||||||||||||||||||||-  65 [G]  COG0036 Pentose-5-phosphate-3-epimerase
14 28 38 66 |||||||||||||||||||||||||||||||||||||| 120 [D]  COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
10 21 27 41 -|||||||-||||-|-||||--||||--|-||||-||-  68 [P]  COG0038 Chloride channel protein EriC
13 26 34 55 |||||-|||||||-|||||||||||||-|||||-||||  71 [C]  COG0039 Malate/lactate dehydrogenases
10 21 28 44 ||||--||||-||-|||||---||||-|||||-||||-  45 [E]  COG0040 ATP phosphoribosyltransferase
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  51 [F]  COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
13 24 32 54 ||||--||---|||||||||||||||-|||||||||||  98 [J]  COG0042 tRNA-dihydrouridine synthase
 9 19 27 41 |||-||||||||--|-|||-|---|--||-||||||||  51 [H]  COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases
11 24 30 48 |||||||||||||-||||||--||||-|||--|-|||-  69 [F]  COG0044 Dihydroorotase and related cyclic amidohydrolases
10 20 29 46 ||-||-|||||||-|-|||-|-|-|--|||||||||||  50 [C]  COG0045 Succinyl-CoA synthetase, beta subunit
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  51 [F]  COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  51 [F]  COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0048 Ribosomal protein S12
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0049 Ribosomal protein S7
12 19 27 53 -------|---||-||||||||||||||||||||||||  73 [J]  COG0050 GTPases - translation elongation factors
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0051 Ribosomal protein S10
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0052 Ribosomal protein S2
12 24 32 47 ||||-||||||||-||||||-|||||-||-|||-||||  67 [P]  COG0053 Predicted Co/Zn/Cd cation transporters
12 23 32 51 ||||--|||||||-|||||||-||||-||||||||||-  55 [H]  COG0054 Riboflavin synthase beta-chain
 9 16 24 48 --|--------||-||||-|--||||||||||||||||  53 [C]  COG0055 F0F1-type ATP synthase, beta subunit
 9 16 24 48 --|--------||-||||-|--||||||||||||||||  53 [C]  COG0056 F0F1-type ATP synthase, alpha subunit
14 28 37 63 |||||||||||||||||||||||||||||||||||||-  93 [G]  COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
11 16 21 35 -||--|--||-|--|-|||||-||||-||-||----|-  43 [G]  COG0058 Glucan phosphorylase
10 20 28 47 |||--|||||-|--|||||---||||-||||||||||-  49 [EH] COG0059 Ketol-acid reductoisomerase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0060 Isoleucyl-tRNA synthetase
12 26 36 62 ||||||||||||||||||-|-|||||||||||||||||  74 [G]  COG0061 Predicted sugar kinase
10 22 28 42 |||||||||||||-|||||---||---||||-|-|||-  42 [S]  COG0062 Uncharacterized conserved protein
11 24 32 49 |||||||||||||||||||---||||-||||-|||||-  52 [G]  COG0063 Predicted sugar kinase
13 25 30 50 ||||--||-||||-||||||||||||||----||||||  52 [J]  COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)
10 22 30 47 ||||-|||||-||-|||||---||||-||||||||||-  56 [E]  COG0065 3-isopropylmalate dehydratase large subunit
10 21 29 47 |||--|||||-||-|||||---||||-||||||||||-  57 [E]  COG0066 3-isopropylmalate dehydratase small subunit
10 20 26 39 |||---||||-||-|||||---||||-||||-|-|||-  45 [E]  COG0067 Glutamate synthase domain 1
 5 12 12 18 |||--|||------|-||-----|----|-----|---  20 [O]  COG0068 Hydrogenase maturation factor
10 20 26 39 |||---||||-||-|||||---||||-||||-|-|||-  52 [E]  COG0069 Glutamate synthase domain 2
10 20 26 39 |||---||||-||-|||||---||||-||||-|-|||-  46 [E]  COG0070 Glutamate synthase domain 3
10 22 29 44 |||||||||||||-|||||---|||--||||-|--|||  91 [O]  COG0071 Molecular chaperone (small heat shock protein)
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0072 Phenylalanyl-tRNA synthetase beta subunit
14 28 38 66 |||||||||||||||||||||||||||||||||||||| 120 [R]  COG0073 EMAP domain
10 20 29 46 ||-||-|||||||-|-|||-|-|-|--|||||||||||  57 [C]  COG0074 Succinyl-CoA synthetase, alpha subunit
 9 20 26 33 ||||||||||||--|||||----|||-||-|---|||-  43 [E]  COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase
 7 15 18 26 ||||-|||--||----||----|-||--|-||----|-  46 [E]  COG0076 Glutamate decarboxylase and related PLP-dependent proteins
10 22 30 47 |||||-||||-||-|||||---||||-||||||||||-  47 [E]  COG0077 Prephenate dehydratase
11 25 34 54 |||||||||||||-|||||--||||||||||||||||-  65 [E]  COG0078 Ornithine carbamoyltransferase
11 24 33 51 |||||||||||||-||||||--||||-||||||||||-  96 [E]  COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0080 Ribosomal protein L11
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0081 Ribosomal protein L1
12 25 34 56 |||||||||||||-|||||||-||||-||||||||||-  56 [E]  COG0082 Chorismate synthase
10 18 24 41 -|-|||-||||||-|||||---||||--||||--|---  41 [E]  COG0083 Homoserine kinase
14 25 35 62 |||--|-|||||||||||||||||||||||||||||||  90 [L]  COG0084 Mg-dependent DNase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  79 [K]  COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  92 [K]  COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0087 Ribosomal protein L3
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0088 Ribosomal protein L4
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0089 Ribosomal protein L23
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0090 Ribosomal protein L2
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0091 Ribosomal protein L22
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  66 [J]  COG0092 Ribosomal protein S3
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0093 Ribosomal protein L14
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0094 Ribosomal protein L5
10 15 19 33 ---|||---||||-||||--|-|-|||||-|-------  61 [H]  COG0095 Lipoate-protein ligase A
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0096 Ribosomal protein S8
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0097 Ribosomal protein L6P/L9E
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0098 Ribosomal protein S5
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0099 Ribosomal protein S13
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0100 Ribosomal protein S11
14 28 36 63 |||||||||--|||||||||||||||||||||||||||  69 [J]  COG0101 Pseudouridylate synthase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0102 Ribosomal protein L13
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0103 Ribosomal protein S9
11 24 32 54 ||||||||||-||-||||||--||||-||||||||||-  55 [F]  COG0104 Adenylosuccinate synthase
12 25 35 57 |||||||||||||||-|||-||||||-|||||||||||  57 [F]  COG0105 Nucleoside diphosphate kinase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  45 [E]  COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  47 [E]  COG0107 Imidazoleglycerol-phosphate synthase
12 23 32 51 ||||--|||||||-|||||||-||||-||||||||||-  57 [H]  COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase
 9 15 21 37 ---||-|-|||||-|-|||---|-|--|||--|--|||  41 [O]  COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor)
10 21 28 44 ||||-|-||--||--||||-|-||||-||-|||||||| 111 [R]  COG0110 Acetyltransferase (isoleucine patch superfamily)
10 23 31 49 |||||||||||||-|||||---||||-||||||-|||- 113 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
13 27 37 64 |||||||||||||||||||-||||||||||||||||||  79 [E]  COG0112 Glycine/serine hydroxymethyltransferase
11 23 32 51 |||||-|||||||-|-|||||-|||--|||||||||||  52 [H]  COG0113 Delta-aminolevulinic acid dehydratase
 9 14 23 42 --||----|||||----||-|-|-|--|||||||||||  43 [C]  COG0114 Fumarase
11 22 30 50 ||||--|||--||-||||||--||||-||||||||||| 112 [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
 7 12 19 32 -|---||||-|------|||---|||-|||||||----  32 [L]  COG0116 Predicted N6-adenine-specific DNA methylase
10 16 23 42 -----------||-|||||||-||||-||||||||||-  42 [H]  COG0117 Pyrimidine deaminase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  47 [E]  COG0118 Glutamine amidotransferase
10 22 30 47 |||-||||||-||-|||||---||||-||||||||||- 102 [E]  COG0119 Isopropylmalate/homocitrate/citramalate synthases
10 22 31 48 ||||||||||||||--|||-||-|||-|||||||-||-  49 [G]  COG0120 Ribose 5-phosphate isomerase
 6 12 17 28 ||--||--||-|----||----|----||-||||--|-  37 [R]  COG0121 Predicted glutamine amidotransferase
 9 18 22 32 |-||-||---||||---||---|||-|||||-|--||-  41 [L]  COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase
 9 19 24 31 ||||-||||||||||-|||-----|--|--|-||-||-  55 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0124 Histidyl-tRNA synthetase
14 27 37 65 |||||||||||||||||||||||-||||||||||||||  70 [F]  COG0125 Thymidylate kinase
14 28 37 64 |||||||||||||||||||||||||||||||||||||-  65 [G]  COG0126 3-phosphoglycerate kinase
14 27 36 57 ||||||||||||||||||||||||||-||||||||||-  59 [F]  COG0127 Xanthosine triphosphate pyrophosphatase
12 25 34 56 |||||||||||||-|||||||-||||-||||||||||-  58 [E]  COG0128 5-enolpyruvylshikimate-3-phosphate synthase
10 21 30 49 |||--||||||||-|||||---||||-||||||||||-  85 [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase
14 28 38 62 ||||||||||||||||||||||||||||||||||||||  67 [J]  COG0130 Pseudouridine synthase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  45 [E]  COG0131 Imidazoleglycerol-phosphate dehydratase
 9 14 20 36 -|---------|--|-||-||-|||--||||||||||-  46 [H]  COG0132 Dethiobiotin synthetase
11 23 30 49 ||||-|||---||-|||||||-||||-||||||||||-  50 [E]  COG0133 Tryptophan synthase beta chain
10 23 32 52 |||||||||||||-|||||---||||-||||||||||-  56 [E]  COG0134 Indole-3-glycerol phosphate synthase
11 24 33 50 |||||||||||||-|||||-|-||||-||||||||||-  50 [E]  COG0135 Phosphoribosylanthranilate isomerase
11 24 34 56 |||||||||||||-|||||-|-||||-|||||||||||  68 [E]  COG0136 Aspartate-semialdehyde dehydrogenase
10 22 30 47 |||||-||||-||-|||||---||||-||||||||||-  47 [E]  COG0137 Argininosuccinate synthase
10 19 26 44 --|||-|----||-||||||--||||-||||||||||-  46 [F]  COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  45 [E]  COG0139 Phosphoribosyl-AMP cyclohydrolase
10 20 28 44 ||||---|||-||-|||||---||||-||||||||||-  44 [E]  COG0140 Phosphoribosyl-ATP pyrophosphohydrolase
10 21 29 45 ||||--||||-||-|||||---||||-||||||||||-  50 [E]  COG0141 Histidinol dehydrogenase
14 27 37 62 ||||||||||||||||||||||||||-||||||||||| 120 [H]  COG0142 Geranylgeranyl pyrophosphate synthase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0143 Methionyl-tRNA synthetase
12 22 31 49 -|-|-|||||||||-||||||-||||-||||||||||-  96 [J]  COG0144 tRNA and rRNA cytosine-C5-methylases
 8 15 18 23 -||-|-|||||||-|-||----|-|---------|||-  49 [EQ] COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit
 7 13 16 20 -||-|--||||||-|-||----|-----------|||-  29 [EQ] COG0146 N-methylhydantoinase B/acetone carboxylase, alpha subunit
11 24 33 54 |||||||||||||-||||||--||||-||||||||||- 102 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I
14 28 37 64 |||||||||||||||||||||||||||||||||||||-  72 [G]  COG0148 Enolase
14 28 37 64 |||||||||||||||||||||||||||||||||||||-  69 [G]  COG0149 Triosephosphate isomerase
11 24 32 51 ||||||||||-||-||||||--||||-||||||||||-  51 [F]  COG0150 Phosphoribosylaminoimidazole (AIR) synthetase
11 24 32 53 ||||||||||-||-||||||--||||-||||||||||-  53 [F]  COG0151 Phosphoribosylamine-glycine ligase
11 24 33 53 ||||||||||-||-||||||--||||-|||||||||||  56 [F]  COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
 9 11 14 23 -----|--|--||--|---|-|||||--|-||------  24 [G]  COG0153 Galactokinase
13 25 32 52 ||||--|||||||-|||||||||||||||---|||||| 113 [J]  COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases
 9 14 20 32 ------|-||-||-|-|||---|||--||||-||-||-  45 [P]  COG0155 Sulfite reductase, beta subunit (hemoprotein)
11 18 25 44 -|--||-----||||-|||||-|-|--|||||||||||  78 [H]  COG0156 7-keto-8-aminopelargonate synthetase and related enzymes
10 21 29 45 ||||-|||||-|--||||-|--||||-||||||||||-  50 [H]  COG0157 Nicotinate-nucleotide pyrophosphorylase
 4  9 14 23 ---|-------||---||---------||-|||||||-  23 [G]  COG0158 Fructose-1,6-bisphosphatase
11 24 33 53 |||||||||||||-|||||-|-||||-||||||||||-  54 [E]  COG0159 Tryptophan synthase alpha chain
 8 15 20 34 --||||--|||||---|-|---|||--||-|||---|-  69 [E]  COG0160 4-aminobutyrate aminotransferase and related aminotransferases
 9 14 20 37 -|---------||-|---|||-|||--||||||||||-  78 [H]  COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  74 [J]  COG0162 Tyrosyl-tRNA synthetase
 9 19 27 41 |||-||||||||--|-|||-|---|--||-||||||||  46 [H]  COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase
14 27 37 60 ||||||||||||||||||||||||||-|||||||||||  60 [L]  COG0164 Ribonuclease HII
10 22 30 47 |||||-||||-||-|||||---||||-||||||||||-  51 [E]  COG0165 Argininosuccinate lyase
14 23 32 57 -|-||---|||||||||||||||||||||||||||||-  60 [G]  COG0166 Glucose-6-phosphate isomerase
11 24 33 55 |||||||||||||-||||||--||||-||||||||||-  67 [F]  COG0167 Dihydroorotate dehydrogenase
11 23 27 43 ||||-|||--|||-||||||-|--|||||-||-||-|-  60 [P]  COG0168 Trk-type K+ transport systems, membrane components
12 25 34 56 |||||||||||||-|||||||-||||-||||||||||-  78 [E]  COG0169 Shikimate 5-dehydrogenase
 8 16 16 20 |||-|||||--||||-||---|---------------|  25 [I]  COG0170 Dolichol kinase
12 26 34 59 |||||||||||||-||||||-||||||||||-|||||-  65 [H]  COG0171 NAD synthase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0172 Seryl-tRNA synthetase
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0173 Aspartyl-tRNA synthetase
10 22 32 54 |||||||||||||-|||||---|-||-||||||||||| 101 [E]  COG0174 Glutamine synthetase
 9 19 26 39 -|||||-||||||---||||--|||--||||-||-||-  73 [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes
10 17 23 44 -|--|------||-|||||-|-||||-||-|||||||-  64 [G]  COG0176 Transaldolase
14 27 37 62 ||||||||||||||||||||||||||-|||||||||||  70 [L]  COG0177 Predicted EndoIII-related endonuclease
11 19 27 52 |-||----------||||||||||||||||||||||||  59 [L]  COG0178 Excinuclease ATPase subunit
 8 20 27 43 |||||||||||||---|||---|-|--||-|||||||-  78 [Q]  COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  72 [J]  COG0180 Tryptophanyl-tRNA synthetase
11 23 32 52 |||||-|||||||-|-|||||-|||--|||||||||||  52 [H]  COG0181 Porphobilinogen deaminase
 9 18 21 24 |||-|||||||||-||||-|----|--|-|------|-  24 [J]  COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
11 23 31 49 ||||||||||||||---|||-|||||-||-|||-|||| 189 [I]  COG0183 Acetyl-CoA acetyltransferase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0184 Ribosomal protein S15P/S13E
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0185 Ribosomal protein S19
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0186 Ribosomal protein S17
13 23 31 58 --|||-|----|||||||||||||||||||||||||||  94 [L]  COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
13 23 31 58 --|||-|----|||||||||||||||||||||||||||  96 [L]  COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
 6 14 22 34 -|||-||-|||-----|||-----|-||||||||-||-  55 [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)
13 22 31 57 --|||---||-||-||||||||||||||||||||||||  64 [H]  COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase
 9 16 22 45 -----------||-|||||--||||||||-|||||||-  71 [G]  COG0191 Fructose/tagatose bisphosphate aldolase
10 17 24 48 -----------||-||||||-||||||||||||||||-  51 [H]  COG0192 S-adenosylmethionine synthetase
11 18 26 52 -----------||-||||||||||||||||||||||||  53 [J]  COG0193 Peptidyl-tRNA hydrolase
11 18 26 51 -----------||||||||||-||||||||||||||||  53 [F]  COG0194 Guanylate kinase
12 25 35 63 |||||||||||---||||||||||||||||||||||||  71 [K]  COG0195 Transcription elongation factor
11 18 25 49 -----------||-|||||||||||||||||||||||-  51 [H]  COG0196 FAD synthase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0197 Ribosomal protein L16/L10E
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0198 Ribosomal protein L24
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  76 [J]  COG0199 Ribosomal protein S14
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0200 Ribosomal protein L15
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [U]  COG0201 Preprotein translocase subunit SecY
14 27 37 65 ||-|||||||||||||||||||||||||||||||||||  68 [K]  COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0203 Ribosomal protein L17
12 19 27 52 -----------||||||||||||||||||||||||||| 137 [I]  COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase
12 17 21 42 -----------||||||||||||||||-||||----|-  50 [G]  COG0205 6-phosphofructokinase
10 23 31 57 ||||||||------||||||-|||||||||||||||||  81 [D]  COG0206 Cell division GTPase
 8 17 24 44 |||---||---|||----||--||||||||||||-||-  47 [F]  COG0207 Thymidylate synthase
13 19 27 49 ---|-----|-||||--|||||||||||||||||||||  62 [F]  COG0208 Ribonucleotide reductase, beta subunit
14 25 35 61 |-|||||-||||||||-|||||||||||||||||||||  88 [F]  COG0209 Ribonucleotide reductase, alpha subunit
12 22 30 57 |-|||------||-|||||||||||||||||||||||| 123 [L]  COG0210 Superfamily I DNA and RNA helicases
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0211 Ribosomal protein L27
12 21 31 52 |--|---||||||-|-||||||||||||||||||||||  55 [H]  COG0212 5-formyltetrahydrofolate cyclo-ligase
 6 13 15 29 -||--||--------|--|---|||||-|-|-|---|-  30 [F]  COG0213 Thymidine phosphorylase
 9 18 21 30 |||||||||||||--|--||--||||-----|------  32 [H]  COG0214 Pyridoxine biosynthesis enzyme
14 25 35 63 --|||||-||||||||||||||||||||||||||||||  67 [J]  COG0215 Cysteinyl-tRNA synthetase
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0216 Protein chain release factor A
11 18 26 51 -----------||-||||||||||||||||||||||||  58 [S]  COG0217 Uncharacterized conserved protein
 7 17 25 47 -|||-|||---|--||---|---|||||||||||||||  47 [R]  COG0218 Predicted GTPase
 7 13 20 40 ----------------|||||-|||||||||||||||-  41 [J]  COG0219 Predicted rRNA methylase (SpoU class)
12 19 27 52 -----------|||||||||||||||||||||||||||  52 [R]  COG0220 Predicted S-adenosylmethionine-dependent methyltransferase
12 24 32 55 |-||||-|-||||||-|||||-|||-||||||||||||  59 [C]  COG0221 Inorganic pyrophosphatase
11 18 26 52 -----------||-||||||||||||||||||||||||  55 [J]  COG0222 Ribosomal protein L7/L12
11 18 26 52 -----------||-||||||||||||||||||||||||  64 [J]  COG0223 Methionyl-tRNA formyltransferase
 9 16 24 48 --|--------||-||||-|--||||||||||||||||  50 [C]  COG0224 F0F1-type ATP synthase, gamma subunit
10 19 26 48 |-||-----|-||---||||-||||||||||||||||-  62 [O]  COG0225 Peptide methionine sulfoxide reductase
10 22 30 48 ||||-||||||---|||||--||||||||||||-|||-  78 [P]  COG0226 ABC-type phosphate transport system, periplasmic component
11 18 26 50 -----------||-||||||||||||||||||||||||  53 [J]  COG0227 Ribosomal protein L28
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0228 Ribosomal protein S16
 9 18 25 45 |-||-------||---||||-||||||||||||||||-  53 [O]  COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase
10 17 25 50 -----------||-|||||-||||||||||||||||||  50 [J]  COG0230 Ribosomal protein L34
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  78 [J]  COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)
 5  7 12 24 -----------------||---|-|--||-|||--|||  28 [F]  COG0232 dGTP triphosphohydrolase
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0233 Ribosome recycling factor
12 19 27 51 --|--------||-||||||||||||||||||||||||  58 [O]  COG0234 Co-chaperonin GroES (HSP10)
10 23 31 47 |||||||||-|||-|||--|--|||||||||||-||||  87 [G]  COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
12 19 27 53 --|--------||-|||||||||||||||||||||||| 115 [IQ] COG0236 Acyl carrier protein
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  67 [H]  COG0237 Dephospho-CoA kinase
11 18 26 51 -----------||-||||||||||||||||||||||||  53 [J]  COG0238 Ribosomal protein S18
 9 19 26 43 -|||-|-|---||-|||||---||||-||||||||||-  60 [D]  COG0239 Integral membrane protein possibly involved in chromosome condensation
13 21 29 52 |-----|----|||||||||||||||||||||||||||  56 [C]  COG0240 Glycerol-3-phosphate dehydrogenase
 8 13 19 30 -|--|------|||---|-|--||---||||||||||-  39 [E]  COG0241 Histidinol phosphatase and related phosphatases
10 16 24 50 --------------||||||||||||||||||||||||  65 [J]  COG0242 N-formylmethionyl-tRNA deformylase
 8 18 24 39 ||-||||||||---|-|||---|-|--||-|||-|||- 149 [C]  COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0244 Ribosomal protein L10
10 16 22 41 --------------|||||||||||-|||||||||||-  41 [I]  COG0245 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
 5  9 14 26 -----------|---|------|||||||-|||--||-  54 [G]  COG0246 Mannitol-1-phosphate/altronate dehydrogenases
 9 19 26 42 |||||-|||||---|-||||--|-||-||-|||||-|- 115 [C]  COG0247 Fe-S oxidoreductase
11 16 23 38 --|------|-|--||||||--|||--|||||||||||  54 [FP] COG0248 Exopolyphosphatase
12 19 27 44 --|||------|||||||||||-|||-|||||||-|||  59 [L]  COG0249 Mismatch repair ATPase (MutS family)
13 26 36 64 |||||||||||-|-||||||||||||||||||||||||  72 [K]  COG0250 Transcription antiterminator
11 18 27 48 ---|-|--|||||-||||||--||||-||||||||||- 142 [J]  COG0251 Putative translation initiation inhibitor, yjgF family
 8 20 28 46 |||||||||||||-----||--||||-||||||||-|-  64 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D
 9 17 24 44 ||----||------||||-||-|||--|||||||||||  46 [E]  COG0253 Diaminopimelate epimerase
10 16 24 50 --------------||||||||||||||||||||||||  64 [J]  COG0254 Ribosomal protein L31
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  69 [J]  COG0255 Ribosomal protein L29
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  67 [J]  COG0256 Ribosomal protein L18
10 17 25 50 -----------||-|||||-||||||||||||||||||  56 [J]  COG0257 Ribosomal protein L36
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  90 [L]  COG0258 5'-3' exonuclease (including N-terminal domain of PolI)
 5  9 15 25 -----------||---|||---|----|||||||-||-  28 [H]  COG0259 Pyridoxamine-phosphate oxidase
11 16 23 44 ----------|-|||-|||||-|-|-||||||||||||  61 [E]  COG0260 Leucyl aminopeptidase
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0261 Ribosomal protein L21
10 15 23 45 --|--------|||-|--|||-||||||||||||-|||  68 [H]  COG0262 Dihydrofolate reductase
10 16 23 39 --|--------||-|||||--|||||-||||||||||-  43 [E]  COG0263 Glutamate 5-kinase
11 17 25 51 ------------|-||||||||||||||||||||||||  51 [J]  COG0264 Translation elongation factor Ts
13 21 30 53 |-||----||-||-||||||||||||-||||||||||| 134 [O]  COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
 5  9 17 37 ----------------|||---|-||||||||||-|||  50 [L]  COG0266 Formamidopyrimidine-DNA glycosylase
11 18 26 51 -----------||-||||||||||||||||||||||||  63 [J]  COG0267 Ribosomal protein L33
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0268 Ribosomal protein S20
 4 11 16 24 |||--||||||------------||||-|-||------  30 [G]  COG0269 3-hexulose-6-phosphate synthase and related proteins
 7 16 24 34 ||---|-||||-|---||----|||||-|||||||||-  63 [L]  COG0270 Site-specific DNA methylase
 4  8 15 26 ---|-------||---||---------|||||||-|||  37 [T]  COG0271 Stress-induced morphogen (activity unknown)
10 16 24 50 --------------||||||||||||||||||||||||  57 [L]  COG0272 NAD-dependent DNA ligase (contains BRCT domain type II)
10 16 20 39 |--||---|-|---|||||--||||||-|-||----|-  44 [F]  COG0274 Deoxyribose-phosphate aldolase
10 16 24 50 --------------||||||||||||||||||||||||  50 [M]  COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis
 9 14 22 43 ----|------||-|-|||-|-|-||-|||||||||||  44 [H]  COG0276 Protoheme ferro-lyase (ferrochelatase)
10 19 27 43 --|||-|-|||||-|-||||--|||--||||||||||- 171 [C]  COG0277 FAD/FMN-containing dehydrogenases
 5  9 16 27 ---|-------|||--||---------|||||||-|||  31 [O]  COG0278 Glutaredoxin-related protein
 7 11 14 25 -|--|---------|--|-|--||---||-||-||-|-  34 [G]  COG0279 Phosphoheptose isomerase
 9 15 23 46 --||-----------|-|||-|||||||||||||||||  70 [C]  COG0280 Phosphotransacetylase
 9 19 29 47 --|||||-|||||--||||---||||-|||||||||||  69 [C]  COG0281 Malic enzyme
 9 15 20 43 --|------------|||||-||||||||-||-||-||  55 [C]  COG0282 Acetate kinase
11 16 24 47 -------------|||||||||||||||||||||-|||  48 [F]  COG0283 Cytidylate kinase
11 24 33 55 |||||||||||||-||||||--||||-||||||||||-  56 [F]  COG0284 Orotidine-5'-phosphate decarboxylase
11 18 26 48 ---||------||-||||||-|||||-|||||||||||  54 [H]  COG0285 Folylpolyglutamate synthase
 5 14 22 36 ||||-||---------|-----|-||||||||||||||  68 [V]  COG0286 Type I restriction-modification system methyltransferase subunit
10 22 31 50 |||||-|||||||-|||||---||||-||||||||||-  51 [E]  COG0287 Prephenate dehydrogenase
 8 15 23 39 |--|----||-||---|||---||||-||||||||||-  57 [P]  COG0288 Carbonic anhydrase
 8 17 25 45 |||---||------||||--|-||||-|||||||||||  46 [E]  COG0289 Dihydrodipicolinate reductase
10 16 24 50 --------------||||||||||||||||||||||||  51 [J]  COG0290 Translation initiation factor 3 (IF-3)
11 17 25 51 -----------|--||||||||||||||||||||||||  51 [J]  COG0291 Ribosomal protein L35
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0292 Ribosomal protein L20
 5 14 21 34 |||||-||---|||-------|-----|||||||-|||  41 [J]  COG0293 23S rRNA methylase
12 25 35 57 |||||||||||||-|||||||-||||-|||||||||||  69 [H]  COG0294 Dihydropteroate synthase and related enzymes
 9 13 18 35 ---|----|-|||--|--|--||||||-|-||---||-  37 [F]  COG0295 Cytidine deaminase
11 14 18 28 --|------|-|--|-|||||-|-||-||-|||---|-  39 [G]  COG0296 1,4-alpha-glucan branching enzyme
11 16 21 32 -|---|--||--|-|||||||--|||-||-|||---|-  38 [G]  COG0297 Glycogen synthase
 4 11 12 18 |||--|||--------||-----|----|--|--|---  22 [O]  COG0298 Hydrogenase maturation factor
11 19 26 44 --|||---|--||-||||||--||||-||||||||||-  45 [F]  COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN
 9 14 17 27 --|--|---|-|||--|--|--||||-|---||--||-  40 [R]  COG0300 Short-chain dehydrogenases of various substrate specificities
 6 15 21 36 |||||||||||----|-----|-||||||-||------  39 [H]  COG0301 Thiamine biosynthesis ATP pyrophosphatase
 9 15 23 41 --------||-||-|-||||--||||-||||||-||||  44 [H]  COG0302 GTP cyclohydrolase I
 8 20 26 44 |||||||||||---|-|||---|||--||-|||-|||-  70 [H]  COG0303 Molybdopterin biosynthesis enzyme
10 16 24 46 -----------||-|||||||-||||-||||||||||| 105 [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase
10 16 24 50 --------------||||||||||||||||||||||||  63 [L]  COG0305 Replicative DNA helicase
10 21 26 46 ||||||||||-|---||-|-|-|||--||-|||||-|-  71 [P]  COG0306 Phosphate/sulphate permeases
11 17 24 43 ---|-------||-|||||||-||||-||||||||||-  43 [H]  COG0307 Riboflavin synthase alpha chain
 9 14 21 36 --|-|---||-|||--|||---|--|-|||||||-||-  51 [E]  COG0308 Aminopeptidase N
 6 15 17 24 |||||||||||---|-||-----|----|-----|---  28 [O]  COG0309 Hydrogenase maturation factor
 4 12 13 13 ||||--||--------||-----||---|--|----|-  24 [P]  COG0310 ABC-type Co2+ transport system, permease component
 8 17 20 29 |||||||||||||--|--|---||||-----|------  31 [H]  COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis
 9 19 27 40 |||-|||||||---|||||---|||--|||||||-||- 102 [R]  COG0312 Predicted Zn-dependent proteases and their inactivated homologs
10 16 24 50 --------------||||||||||||||||||||||||  53 [R]  COG0313 Predicted methyltransferases
 8 18 24 41 |||||||-|||---|-|||---|-|--||-|||-|||-  45 [H]  COG0314 Molybdopterin converting factor, large subunit
 8 20 26 43 |||||||||||---|-|||---|||--||-|||-|||-  47 [H]  COG0315 Molybdenum cofactor biosynthesis enzyme
 8 12 19 35 --|--------||-|-|||---|-|--|||||||-|||  80 [S]  COG0316 Uncharacterized conserved protein
 9 15 23 44 --------------||||||-|||||||||||||||||  67 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases
 9 18 28 47 |-|||-|-|||||---|||-|-|-||-||||||||||| 257 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II
10 16 24 50 --------------||||||||||||||||||||||||  50 [R]  COG0319 Predicted metal-dependent hydrolase
10 14 23 40 ---|----|||||-|-|||-|-|-|--|||||||-|||  43 [H]  COG0320 Lipoate synthase
 6 10 17 31 --------|--||---|||---|----|||||||-|||  31 [H]  COG0321 Lipoate-protein ligase B
11 19 27 52 |-||----------||||||||||||||||||||||||  63 [L]  COG0322 Nuclease subunit of the excinuclease complex
12 18 26 44 --||-------|||||||||||-|||-|||||||-|||  49 [L]  COG0323 DNA mismatch repair enzyme (predicted ATPase)
11 17 25 48 -----------||-||||||||||||-|||||||||||  52 [J]  COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase
10 16 23 43 --|--------||-||||||--||||-||||||||||-  44 [R]  COG0325 Predicted enzyme with a TIM-barrel fold
 8 14 19 35 -----------|||--||-|-||||--||||||-|-||  37 [O]  COG0326 Molecular chaperone, HSP90 family
11 22 27 47 ||||-|||---|||--|-|||||||||||-|||||---  56 [S]  COG0327 Uncharacterized conserved protein
 9 14 21 39 ---|----|--||---|||--||-|--|||||||||||  44 [L]  COG0328 Ribonuclease HI
10 22 32 56 |||||||||||---||||-||-||||-||||||||||| 114 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase
12 26 36 57 |||||||||||||-||||||-||||||||||||||||| 130 [O]  COG0330 Membrane protease subunits, stomatin/prohibitin homologs
10 16 24 45 -----------||-|||||||-||||-|||||||||||  65 [I]  COG0331 (acyl-carrier-protein) S-malonyltransferase
 8 13 21 40 --------------|-|||||-||||-|||||||||||  63 [I]  COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III
10 17 25 48 -----------||-||||||||-|||||||||||||||  49 [J]  COG0333 Ribosomal protein L32
11 21 28 42 --|||||-|||||--||||||-||||-||--||||||-  66 [E]  COG0334 Glutamate dehydrogenase/leucine dehydrogenase
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [J]  COG0335 Ribosomal protein L19
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0336 tRNA-(guanine-N1)-methyltransferase
11 18 27 49 ----||--|||||--||||||-||||-||||||||||-  50 [E]  COG0337 3-dehydroquinate synthetase
 6 13 16 24 -|--||----------||-|-|-||---||||-||--|  29 [L]  COG0338 Site-specific DNA methylase
 5  9 15 24 -----------||---|||---|----|||||||-||-  30 [E]  COG0339 Zn-dependent oligopeptidases
13 24 32 54 ||||-||--|-||-||||||||||||-|||||||||||  58 [H]  COG0340 Biotin-(acetyl-CoA carboxylase) ligase
11 22 29 50 ||||-|-|------|||||||||||-||||||||||||  52 [U]  COG0341 Preprotein translocase subunit SecF
11 22 29 50 ||||-|-|------|||||||||||-||||||||||||  55 [U]  COG0342 Preprotein translocase subunit SecD
14 26 36 57 |||||||||||-||||||||||||||-|||||||||||  61 [J]  COG0343 Queuine/archaeosine tRNA-ribosyltransferase
 7 13 19 38 --------------||||||---||||||-|||||||-  41 [S]  COG0344 Predicted membrane protein
11 19 28 48 |-|-|---|||||-|||||--|||||-||||||||||-  56 [E]  COG0345 Pyrroline-5-carboxylate reductase
 9 19 27 45 |-||-||--||||---||||--||||-||||||||||- 252 [E]  COG0346 Lactoylglutathione lyase and related lyases
 8 16 23 35 |||---||------|||||---||||-|||||||-||-  67 [E]  COG0347 Nitrogen regulatory protein PII
 5 13 18 29 -||-|-||-|------||-----|---||-|||||||-  43 [C]  COG0348 Polyferredoxin
 5  7 13 25 -----------|----||----||---|||||---|||  33 [J]  COG0349 Ribonuclease D
12 24 34 55 ||||||||||||--|||--|||||||||||||||||||  83 [L]  COG0350 Methylated DNA-protein cysteine methyltransferase
12 24 33 54 |||||||||||||-|||-||-|||||-||||||||||-  66 [H]  COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
 9 18 25 45 --|-|||----||-|-||||--||||-||||||||||-  60 [H]  COG0352 Thiamine monophosphate synthase
 9 15 23 45 --------------|-||||||||||||||||||||||  45 [L]  COG0353 Recombinational DNA repair protein (RecF pathway)
 6 10 17 31 -----------||-|-|||---|----|||||||-|||  31 [R]  COG0354 Predicted aminomethyltransferase related to GcvT
 9 16 24 48 --|--------||-||||-|--||||||||||||||||  50 [C]  COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit)
 9 15 23 47 --|--------|--||||-|--||||||||||||||||  47 [C]  COG0356 F0F1-type ATP synthase, subunit a
 9 15 23 47 --------------||||||-|||||||||||||||||  47 [M]  COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division
12 25 35 63 |||||||||||---||||||||||||||||||||||||  70 [L]  COG0358 DNA primase (bacterial type)
11 17 25 51 ------------|-||||||||||||||||||||||||  51 [J]  COG0359 Ribosomal protein L9
11 18 26 51 -----------||-||||||||||||||||||||||||  51 [J]  COG0360 Ribosomal protein S6
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  71 [J]  COG0361 Translation initiation factor 1 (IF-1)
 9 13 16 34 -----------|||-|||--|||-||--|-||-|--|-  36 [G]  COG0362 6-phosphogluconate dehydrogenase
10 17 24 44 -----------|||-|||-||||||||||||||||||-  61 [G]  COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase
11 16 23 41 -----------||||||||-|||-||-||||||||||-  48 [G]  COG0364 Glucose-6-phosphate 1-dehydrogenase
10 19 27 40 |-|||-|-|||||||-|||---|-||-||||||-|||- 119 [I]  COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases
 9 16 20 34 --|-|---|--||--||||---|||||||-|-|--||- 137 [G]  COG0366 Glycosidases
 7 17 22 34 |||||||||-||||--------||||-||||-----|-  52 [E]  COG0367 Asparagine synthase (glutamine-hydrolyzing)
 8 19 23 34 |||||||||||-----||||--|||--||-|-|---|-  35 [H]  COG0368 Cobalamin-5-phosphate synthase
 6 10 14 24 -----------|||--||--|---|--||||--|-||-  34 [P]  COG0369 Sulfite reductase, alpha subunit (flavoprotein)
 8 18 22 30 |||--||||-----|||||----|||-||||-|-||--  37 [P]  COG0370 Fe2+ transport system protein B
 7 17 20 30 |||||||||||-|--|||-----|||--|-------|-  37 [C]  COG0371 Glycerol dehydrogenase and related enzymes
10 19 29 47 |-|||-|-|||||-|||||---|-||-|||||||||||  80 [C]  COG0372 Citrate synthase
10 20 27 42 |||||-|||||---|-|||||-|||--||||||||---  42 [H]  COG0373 Glutamyl-tRNA reductase
 5  8  8 13 --|---||------|-|------|----|-----|---  21 [C]  COG0374 Ni,Fe-hydrogenase I large subunit
 5 12 12 18 |||--|||------|-|||---------|-----|---  24 [R]  COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)
 6 10 13 20 --||--|----|-----|----|-|---|||-|--||-  21 [P]  COG0376 Catalase (peroxidase I)
 8 16 23 38 --|||||-|||---|||||---|----|||--||||||  39 [C]  COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases
 9 18 20 32 |||---||----|-|-||||--|-|-|||--||-|-|-  47 [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase
 9 20 26 40 ||||-|||||----||||-|--|||--||||-|||||-  42 [H]  COG0379 Quinolinate synthase
 7 11 11 19 |---|---|--|||---|----|-----|---|---|-  30 [G]  COG0380 Trehalose-6-phosphate synthase
 6 14 19 29 ||-|-|---------||||----|||-||-|||||--|  36 [M]  COG0381 UDP-N-acetylglucosamine 2-epimerase
10 23 32 49 |||||||||||||-|-|||-|-|||--|||||||||||  77 [H]  COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases
 8 11 12 16 ----||---|-||--|||----|-||--|---------  22 [G]  COG0383 Alpha-mannosidase
 8 14 18 28 --||-------||---||||--|||--||-|||--||-  43 [R]  COG0384 Predicted epimerase, PhzC/PhzF homolog
 7 10 13 24 --|--------|--|-||----|-|--||---||-||-  36 [R]  COG0385 Predicted Na+-dependent transporter
 7 12 16 26 -----------|||---|-|--||||||||--||-|--  36 [O]  COG0386 Glutathione peroxidase
 6  9  9 18 -----------||---|||---|-|---|-------|-  21 [P]  COG0387 Ca2+/H+ antiporter
11 22 30 48 |-|||||-|||||-|||||--|||||-||||-|||||- 126 [R]  COG0388 Predicted amidohydrolase
 8 15 21 39 --||-----|-||---||-|--|||||||-||||-||-  76 [L]  COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair
 7 10 10 15 -||-----------||||----|-|---|---|-----  15 [R]  COG0390 ABC-type uncharacterized transport system, permease component
 9 16 19 31 ||||--||---|--|||||---||||--|-||------  34 [S]  COG0391 Uncharacterized conserved protein
 7 18 20 35 ||||-|||------||||----|||-||||--|---|-  61 [S]  COG0392 Predicted integral membrane protein
 7 15 18 26 |||||||--|-----|||----|-||--|-||---|--  29 [S]  COG0393 Uncharacterized conserved protein
 8 17 24 38 |-||--|----||-|-|||---||||-||||||||||-  70 [T]  COG0394 Protein-tyrosine-phosphatase
 9 16 23 41 ---|||--|||----||||--||||||||||||---|- 207 [G]  COG0395 ABC-type sugar transport system, permease component
10 20 25 43 |||||||||||----||||-||||||--||-----||-  46 [O]  COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
 5  9 13 17 -----------||---||----|-|--||||-|--||-  18 [S]  COG0397 Uncharacterized conserved protein
 6 11 14 23 --||-------||---||----||||--|-|----||-  38 [S]  COG0398 Uncharacterized conserved protein
 9 17 23 34 ||---|-||-----||||---|||||-||-|||||||-  68 [M]  COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis
 6  9 13 23 -----------||---|||-|---||-|||------||  30 [R]  COG0400 Predicted esterase
 3  6  7 10 -----------||---||---------||-------|-  15 [S]  COG0401 Uncharacterized homolog of Blt101
10 23 30 42 |||||||||||||-|||||---||||-|||-||-|||-  96 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
10 16 21 35 ---|||---||||-|||||---|-|--|||--||-||-  36 [E]  COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain
10 16 21 36 ---|||---||||-|||||---|-|--|||--||-||-  79 [E]  COG0404 Glycine cleavage system T protein (aminomethyltransferase)
10 15 22 34 ----|---||||||--||||--|-|--||||-|||||-  48 [E]  COG0405 Gamma-glutamyltransferase
11 17 23 39 --|-|----|-||-||||||--||||-||||||--||- 132 [G]  COG0406 Fructose-2,6-bisphosphatase
 9 15 22 41 --|-|------||-|-|||-|-|-|--|||||||||||  54 [H]  COG0407 Uroporphyrinogen-III decarboxylase
 3  7 12 20 -----------||---||---------||||-|--|||  21 [H]  COG0408 Coproporphyrinogen III oxidase
 5 12 12 18 |||--|||------|-||-----|----|-----|---  19 [O]  COG0409 Hydrogenase maturation factor
 9 14 18 25 -|----|-|||----|||||--|-||-||---|-|-|-  72 [E]  COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
 8 13 16 23 -|----|-|||----|||||-----|-||---|-|-|-  60 [E]  COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
 8 13 15 23 --|-|----|-||-|-||----|-|--||---|--||-  50 [Q]  COG0412 Dienelactone hydrolase and related enzymes
10 17 24 42 ---|-|--|||||-|||||---|||--||||-|||||-  46 [H]  COG0413 Ketopantoate hydroxymethyltransferase
 8 14 19 36 -----------||-|||||---|||--||||-|||||-  37 [H]  COG0414 Panthothenate synthetase
 7 12 16 23 |-||-----|-|----||----|-||-||-|--|-||-  28 [L]  COG0415 Deoxyribodipyrimidine photolyase
 8 14 20 39 --------------|||||||--||||||-|||||||-  39 [I]  COG0416 Fatty acid/phospholipid biosynthesis enzyme
 6 14 18 24 ||||||||||||||--|----------||-|-------  47 [L]  COG0417 DNA polymerase elongation subunit (family B)
 3  7 10 19 -----------||----|---------||-|-|||-|-  19 [F]  COG0418 Dihydroorotase
12 22 27 36 ||||||||||||||||||||-|-|||-||-|-------  41 [L]  COG0419 ATPase involved in DNA repair
13 24 29 42 ||||||||||||||||||||-|||||-||-|-----|-  47 [L]  COG0420 DNA repair exonuclease
 9 18 24 34 -|--|||||||||-||--|---||||-|||--|||-|-  41 [E]  COG0421 Spermidine synthase
10 21 27 38 ||||-|||||----||||||--|||--||||-|||||-  42 [H]  COG0422 Thiamine biosynthesis protein ThiC
 8 18 20 29 ||||||||||||||----|--||||-|-----------  30 [J]  COG0423 Glycyl-tRNA synthetase (class II)
11 18 25 42 --|--|-----||-|||||||-|||--|||||||||||  57 [D]  COG0424 Nucleotide-binding protein implicated in inhibition of septum formation
 8 18 24 36 |||||-||||----||||-|----|--||-|||||||-  72 [O]  COG0425 Predicted redox protein, regulator of disulfide bond formation
 7 13 14 18 |||--||-------||||-|---|---||---|-----  39 [C]  COG0426 Uncharacterized flavoproteins
 6  9 11 16 ---|--|----||----|-|--|----||------||-  19 [C]  COG0427 Acetyl-CoA hydrolase
12 20 24 31 ||||-|--|||||||||-|--||-|--||---|||-|-  38 [P]  COG0428 Predicted divalent heavy-metal cations transporter
 4  6  9 14 -----------|-|--||---------||-|-||----  16 [R]  COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold
 7 15 18 22 ||||-||||||||||-|----------||---|-----  22 [A]  COG0430 RNA 3'-terminal phosphate cyclase
 7 12 18 33 ---|-------||---|||---|-|||||-||||-||-  59 [R]  COG0431 Predicted flavoprotein
10 18 22 29 |||--||||||-|-|||||---|||--||-|-----|-  36 [S]  COG0432 Uncharacterized conserved protein
 9 19 25 34 |||||||||||---|||||---|-||-||--||--||-  71 [R]  COG0433 Predicted ATPase
 4 10 11 14 -|-|-||||-|-----||----------|-------|-  14 [R]  COG0434 Predicted TIM-barrel enzyme
 5  8 10 16 ---|-------||---||----|----||-|-----|-  18 [O]  COG0435 Predicted glutathione S-transferase
13 26 36 59 |||||||||||||-||||||||||||-||||||||||| 193 [E]  COG0436 Aspartate/tyrosine/aromatic aminotransferase
 4 10 15 21 --||-||-|||---|------------||-|||-|-|-  73 [C]  COG0437 Fe-S-cluster-containing hydrogenase components 1
13 26 36 58 ||||||||||||||||||||-|||||-||||||||||| 488 [M]  COG0438 Glycosyltransferase
11 20 27 45 |||---|--|-||-|-|||-||||||-||||||||||-  71 [I]  COG0439 Biotin carboxylase
10 21 27 45 |||--|||--|||-|||||---||||-||-|||||||-  50 [E]  COG0440 Acetolactate synthase, small (regulatory) subunit
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  75 [J]  COG0441 Threonyl-tRNA synthetase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0442 Prolyl-tRNA synthetase
13 23 31 58 |-|||------||||||||||||||||||||||||||| 134 [O]  COG0443 Molecular chaperone
11 20 26 47 --|||||-|||---||--|||||||||||-|||-|-|- 163 [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
10 17 25 48 -----------||-||||||||-|||||||||||||||  50 [D]  COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division
12 25 32 50 |||||||||||||-||||||-||||||||-|||--||- 171 [R]  COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases
 5  7 10 20 ---|--|---------||----|-||--|-||------  20 [H]  COG0447 Dihydroxynaphthoic acid synthase
 8 11 14 27 ---------------||||||-||||--|-||----|-  36 [G]  COG0448 ADP-glucose pyrophosphorylase
14 26 35 58 ||||||-|||||||||||||||||||-||||||||||-  71 [M]  COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
14 24 33 53 |||-|||-|||||||||||||||-||-||||||-||||  72 [O]  COG0450 Peroxiredoxin
12 25 33 53 ||||||||||-||-||||||-|||||-||||||||||- 289 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases
12 25 34 55 |||||||||||||-||||||-|||||-||||||||||-  66 [H]  COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase
13 26 36 58 |||||||-|||||||||||||-|||||||||||||||| 542 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
 8 16 17 24 ||-|-|||------|||----||||--|--|-|-|---  46 [D]  COG0455 ATPases involved in chromosome partitioning
12 26 35 54 ||||||||||||||||||||--|||||||||||||||- 112 [R]  COG0456 Acetyltransferases
13 25 33 53 |||||||--|-|||||||||||-|||-||||||||||| 510 [R]  COG0457 FOG: TPR repeat
11 23 31 51 |||||-||||-||-||||||--||||-||||||||||-  66 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
14 28 38 64 |||||||||||||||||||||||||||||||||||||| 122 [O]  COG0459 Chaperonin GroEL (HSP60 family)
10 23 32 53 |||||||||||||-|||||---||||-||||||||||-  62 [E]  COG0460 Homoserine dehydrogenase
12 25 34 56 |||||||||||||-|||||||-||||-||||||||||-  59 [F]  COG0461 Orotate phosphoribosyltransferase
12 26 36 62 |||||||||||||-||||||-|||||||||||||||||  76 [FE] COG0462 Phosphoribosylpyrophosphate synthetase
13 27 37 62 ||||||||||||||||||||-||||||||||||||||| 434 [M]  COG0463 Glycosyltransferases involved in cell wall biogenesis
 9 21 23 31 ||||||||||||||--|||---|-|--|----|-|-|- 107 [O]  COG0464 ATPases of the AAA+ class
11 18 26 52 -----------||-||||||||||||||||||||||||  74 [O]  COG0465 ATP-dependent Zn proteases
10 16 23 42 --|--------||-||--||||-||-||||||||||||  46 [O]  COG0466 ATP-dependent Lon protease, bacterial type
 7 15 17 21 ||||||||||||--||||------------------|-  70 [T]  COG0467 RecA-superfamily ATPases implicated in signal transduction
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  87 [L]  COG0468 RecA/RadA recombinase
13 24 33 57 -|||||--||||||-||||||||||||||||||||||-  71 [G]  COG0469 Pyruvate kinase
14 27 37 64 |||||||||||||||||||||||-|||||||||||||| 108 [L]  COG0470 ATPase involved in DNA replication
10 19 25 41 ||-|-|-||--||-|--||-|-||||-||||||||-|-  77 [P]  COG0471 Di- and tricarboxylate transporters
13 22 30 54 ||---|-|||-||-||||||||||||-||||||||-||  91 [M]  COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
10 21 30 48 |||--|||||-||-|||||---||||-|||||||||||  75 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase
 9 17 19 35 |||-|------||||-||-|--|||||||-------|-  93 [P]  COG0474 Cation transport ATPase
10 21 31 49 |||-|||-|||||-|-|||--|||||-|||||||||||  85 [P]  COG0475 Kef-type K+ transport systems, membrane components
11 22 31 50 |-|||||-|||||||-||||--||||-||||||||||-  86 [H]  COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
14 28 38 65 |||||||||||||||||||||||||||||||||||||| 537 [GEPR] COG0477 Permeases of the major facilitator superfamily
 4 10 12 13 -|||-|||||||||------------------------  14 [T]  COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
10 20 29 48 ||-||-|||||||-|-|||-|-|-|--|||||||||||  62 [C]  COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  97 [J]  COG0480 Translation elongation factors (GTPases)
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [M]  COG0481 Membrane GTPase LepA
11 18 26 51 -----------||-||||||||||||||||||||||||  58 [J]  COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain
11 21 31 50 ||||-|||||||--|||||--||-||-|||||||||||  92 [G]  COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
13 23 31 58 |-|||------|||||||||||||||||||||||||||  73 [O]  COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain
10 17 25 48 -----------||-||||||||-|||||||||||||||  48 [R]  COG0486 Predicted GTPase
10 17 25 48 -----------|||--|||||||||||||||||||||| 159 [R]  COG0488 ATPase components of ABC transporters with duplicated ATPase domains
12 25 35 55 ||||||||||||||||||||--||||-||||||||||| 104 [D]  COG0489 ATPases involved in chromosome partitioning
 5  6  7 10 ------|-------|---|---||||------------  11 [P]  COG0490 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels
12 25 34 56 ||||||||||||||||||||--||||-||||||||||- 271 [R]  COG0491 Zn-dependent hydrolases, including glyoxylases
14 27 37 65 ||||||||||||-||||||||||||||||||||||||| 121 [O]  COG0492 Thioredoxin reductase
12 19 26 42 --|-||--|-||||||-||--|||||-||||-|-||||  77 [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
14 24 34 57 |-|||-|-||||||||||||||||||-||||||||||| 335 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  70 [J]  COG0495 Leucyl-tRNA synthetase
10 19 26 38 ||||--|||-||--|||||-||-----||||||||||-  41 [R]  COG0496 Predicted acid phosphatase
 8 13 21 41 --------------|-||||-|||||-|||||||||||  41 [L]  COG0497 ATPase involved in DNA repair
10 23 32 53 |||||||||||||-|||||---||||-||||||||||-  70 [E]  COG0498 Threonine synthase
 8 19 23 31 |||||||||||||-||||----|----|-|--|--||-  32 [H]  COG0499 S-adenosylhomocysteine hydrolase
14 27 37 61 ||||||||||||||||||||||||||-||||||||||| 786 [QR] COG0500 SAM-dependent methyltransferases
11 24 33 53 |||||||||||||||-||||--||||-||||||||||- 110 [O]  COG0501 Zn-dependent protease with chaperone function
10 19 25 41 |||----|---||-||||-||-|||--||||||||||-  49 [H]  COG0502 Biotin synthase and related enzymes
11 23 30 54 ||||-|-||||||--|||||-||||||||-|||||-|-  93 [F]  COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
13 27 37 63 |||||||||||||||||||-||||||||||||||||||  67 [F]  COG0504 CTP synthase (UTP-ammonia lyase)
11 23 31 51 |||||-||||-||-||||||--||||-||||||||||-  55 [EF] COG0505 Carbamoylphosphate synthase small subunit
 7 12 16 30 ---|-------||---|||---|-|--||--||||||-  32 [E]  COG0506 Proline dehydrogenase
 9 15 20 37 -|---------||---|-|-||||||||||||-||-|-  52 [L]  COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member
 9 15 25 48 ---||---|||||---|||-|-|-||||||||||-||| 122 [C]  COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes
11 18 25 41 ---|||---||||-|||||-|-|-|||||||-||-||-  50 [E]  COG0509 Glycine cleavage system H protein (lipoate-binding)
 5  8 11 22 -----------||------|-|--|||-|-||----|-  27 [M]  COG0510 Predicted choline kinase involved in LPS biosynthesis
13 23 30 51 |||--||--|-||-||||||||||||-||||||||||-  78 [I]  COG0511 Biotin carboxyl carrier protein
11 24 33 54 |||||||||||||-||||||--||||-||||||||||-  79 [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II
12 23 31 55 |||-|-|--|-||||-||||-||||||||||||||||| 218 [LKJ] COG0513 Superfamily II DNA and RNA helicases
11 16 23 34 --|-------||||--||||-|||||-|||||||-||-  46 [L]  COG0514 Superfamily II DNA helicase
11 19 25 41 ---||---||-||||-|||-|-|||||||||||-|-|- 407 [RTKL] COG0515 Serine/threonine protein kinase
13 24 31 53 ||-|||-|--|||-||||||||||||-||||||||||- 138 [F]  COG0516 IMP dehydrogenase/GMP reductase
13 26 36 59 |||||||||||||-||||||||||||-||||||||||| 330 [R]  COG0517 FOG: CBS domain
13 26 35 56 |||||||||||||-||||||||||||-||||||||||-  83 [F]  COG0518 GMP synthase - Glutamine amidotransferase domain
13 26 35 56 |||||||||||||-||||||||||||-||||||||||-  56 [F]  COG0519 GMP synthase, PP-ATPase domain/subunit
12 22 29 53 |-||-|-|-||-|--||||||||||||||||||-|||-  89 [E]  COG0520 Selenocysteine lyase
 8 19 25 43 |||||||||||---|-|-|---|||--||-|||-|||-  54 [H]  COG0521 Molybdopterin biosynthesis enzymes
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  76 [J]  COG0522 Ribosomal protein S4 and related proteins
 9 14 19 32 --|--------||-|-||||--|-|--||||-|||||-  67 [R]  COG0523 Putative GTPases (G3E family)
 9 21 29 47 |||||||||||||--||||---||||-||||||--||- 202 [G]  COG0524 Sugar kinases, ribokinase family
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [J]  COG0525 Valyl-tRNA synthetase
14 27 37 65 |||||||-|||||||||||||||||||||||||||||| 357 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins
11 24 34 56 |||||||||||||-|||||-|-||||-|||||||||||  85 [E]  COG0527 Aspartokinases
12 25 35 63 |||||||||||---||||||||||||||||||||||||  63 [F]  COG0528 Uridylate kinase
 9 15 19 28 -----||---|||-|--||---|||--||||-|-|||-  33 [P]  COG0529 Adenylylsulfate kinase and related kinases
 9 18 21 28 ||||||||||-||-||-|---|--|---|-||----|-  37 [P]  COG0530 Ca2+/Na+ antiporter
10 22 31 53 |||||-||||||||--||-||-|||||||||||--||| 257 [E]  COG0531 Amino acid transporters
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  72 [J]  COG0532 Translation initiation factor 2 (IF-2; GTPase)
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  68 [O]  COG0533 Metal-dependent proteases with possible chaperone activity
12 23 30 53 ||||-||---|||-||-|||-||||||||||||||||- 140 [V]  COG0534 Na+-driven multidrug efflux pump
 9 20 23 29 |||||||||||---|||||---||||-|----|---|-  98 [R]  COG0535 Predicted Fe-S oxidoreductases
11 18 26 52 -----------||-||||||||||||||||||||||||  52 [R]  COG0536 Predicted GTPase
13 26 36 63 |||||||-|||||||-|||||||||||||||||||||| 108 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
10 17 23 36 ---||-|-|||||-|||||---|-||-||--||-|||-  38 [C]  COG0538 Isocitrate dehydrogenases
11 18 26 49 -----------||-||||||||||||||||||||||||  52 [J]  COG0539 Ribosomal protein S1
11 24 32 53 |||||||||||||-||||||--||||-||||-|||||-  53 [F]  COG0540 Aspartate carbamoyltransferase, catalytic chain
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  66 [U]  COG0541 Signal recognition particle GTPase
13 20 28 52 |----------||||||||||||||||||||||||||| 128 [O]  COG0542 ATPases with chaperone activity, ATP-binding subunit
10 20 25 38 |||-||||-|-||-||---|-|||||-||-|-||--||  67 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
10 16 24 50 --------------||||||||||||||||||||||||  51 [O]  COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)
 7 11 16 24 -----------||---|||-|||----|||||||-|--  45 [O]  COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1
 9 19 26 46 |-||-||----|--|-|||--||||||||||||||||-  91 [R]  COG0546 Predicted phosphatases
10 23 32 52 |||||||||||||-|||||---||||-||||||||||-  66 [E]  COG0547 Anthranilate phosphoribosyltransferase
10 21 31 47 |||--||||||||-|||||---||||-|||||||||||  60 [E]  COG0548 Acetylglutamate kinase
 5  9 13 20 ---|||--|-|------|------|||||--|----|-  30 [E]  COG0549 Carbamate kinase
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  90 [L]  COG0550 Topoisomerase IA
 7 17 23 42 |||||||--------|---|||-||||||||||||---  57 [L]  COG0551 Zn-finger domain associated with topoisomerase type I
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  66 [U]  COG0552 Signal recognition particle GTPase
12 21 27 41 --|||||--|||||-||||||-||||||||||----|- 109 [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
12 20 27 46 ---||||--|||--||||||-||||||||||||--||-  52 [C]  COG0554 Glycerol kinase
 7 18 25 37 ||||||||||------|||---|||--|||||||-||-  42 [O]  COG0555 ABC-type sulfate transport system, permease component
11 19 27 52 |-||----------||||||||||||||||||||||||  53 [L]  COG0556 Helicase subunit of the DNA excision repair complex
13 20 27 48 ---|-------||||||||||||||||||||||||||-  62 [K]  COG0557 Exoribonuclease R
13 25 35 62 |-|||||-||||||||||-||||||||||||||||||| 104 [I]  COG0558 Phosphatidylglycerophosphate synthase
 9 14 18 25 -|----|-|||----|||||--|-||-||---|-|-|-  73 [E]  COG0559 Branched-chain amino acid ABC-type transport system, permease components
 8 20 27 43 |||||||||-|||------||-||-|-||||||||||-  76 [E]  COG0560 Phosphoserine phosphatase
13 25 31 55 |-||||||||||||-||||||||||||-|-||||--|- 171 [R]  COG0561 Predicted hydrolases of the HAD superfamily
 5  8  8 13 |-----------------|---||--|-|-----|-|-  13 [M]  COG0562 UDP-galactopyranose mutase
13 23 31 58 --||-||----|||||||||||||||||||||||||||  85 [F]  COG0563 Adenylate kinase and related kinases
12 19 27 53 -----------||||||||||||||||||||||||||| 146 [J]  COG0564 Pseudouridylate synthases, 23S RNA-specific
 5 14 22 32 |||||-||-||-----|||--------|||||||-|||  36 [J]  COG0565 rRNA methylase
12 19 27 52 ------|----||-|||||||||||||||||||||||| 109 [J]  COG0566 rRNA methylases
 6  9 16 33 -----------||-----|-|-|-|--|||||||-|||  38 [C]  COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes
10 16 24 50 --------------|||||||||||||||||||||||| 103 [K]  COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)
11 22 27 44 ||||-||||-|---||||||-||-|||||-||-||-|-  70 [P]  COG0569 K+ transport systems, NAD-binding component
11 18 26 52 -----------||-||||||||||||||||||||||||  57 [K]  COG0571 dsRNA-specific ribonuclease
 9 13 16 29 ---|-------||--||||-||-||||-|-||------  35 [F]  COG0572 Uridine kinase
10 22 29 47 ||||-||||||---|||||--||||||-|||||-|||-  54 [P]  COG0573 ABC-type phosphate transport system, permease component
11 23 32 49 |||||||||||---||||||-|||||-||||-||||||  73 [G]  COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase
14 28 38 65 ||||||||||||||||||||||||||||||||||||||  66 [I]  COG0575 CDP-diglyceride synthetase
12 22 30 57 |-|||------||-||||||||||||||||||||||||  60 [O]  COG0576 Molecular chaperone GrpE (heat shock protein)
11 21 28 44 ||||--||||-----|||||||||||-||-|||||||- 169 [V]  COG0577 ABC-type antimicrobial peptide transport system, permease component
10 14 19 36 ---||----|-|||---||--||-||-||||||---|-  53 [C]  COG0578 Glycerol-3-phosphate dehydrogenase
 8 16 21 35 ----|||---|----|||-|--|||-|||||-|||||-  44 [R]  COG0579 Predicted dehydrogenase
11 17 22 38 |-----|--|-|||-|-|||-|-|||||||-||--||-  60 [G]  COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
10 22 30 48 ||||-||||||---|||||--||||||||||||-|||-  57 [P]  COG0581 ABC-type phosphate transport system, permease component
11 23 32 56 |||||||--||---|||||||-|||||||||||||||| 371 [L]  COG0582 Integrase
 8 16 23 40 ||----||------|-||||--||||-||||||||||- 904 [K]  COG0583 Transcriptional regulator
12 19 25 44 ---|||--|-||||-||-||-||||||||-|||--||-  93 [C]  COG0584 Glycerophosphoryl diester phosphodiesterase
 7 16 21 30 |||||||||||||||---|--------||-||--|---  31 [S]  COG0585 Uncharacterized conserved protein
 8 13 20 38 ----|----|------|||--|||||-||||||||||-  89 [S]  COG0586 Uncharacterized membrane-associated protein
10 16 24 50 --------------||||||||||||||||||||||||  67 [L]  COG0587 DNA polymerase III, alpha subunit
 8 12 17 34 --|--------||------|||||||--||-|||-||-  37 [G]  COG0588 Phosphoglycerate mutase 1
 9 19 28 48 |||||||||||-|-|-|||---|-||-||-||||-||| 207 [T]  COG0589 Universal stress protein UspA and related nucleotide-binding proteins
10 15 23 42 --|--------||||-|||-|-||||-|||||||-|||  65 [FJ] COG0590 Cytosine/adenosine deaminases
 9 18 25 41 |-|||||--||||----|-||-|-||-||-|||||-||  70 [ER] COG0591 Na+/proline symporter
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  74 [L]  COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
 9 15 23 49 --------------|||||-||||||||||||||||||  73 [L]  COG0593 ATPase involved in DNA replication initiation
 9 15 23 48 ---------------|||||||||||||||||||||||  48 [J]  COG0594 RNase P protein component
 8 17 20 38 ||||-|-|-------|||||--|||||-------||||  55 [R]  COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily
12 22 32 55 --|||-|-|||||||-||||-||||||||||||||||| 481 [R]  COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 
10 16 24 50 --------------||||||||||||||||||||||||  50 [MU] COG0597 Lipoprotein signal peptidase
11 20 28 45 -||--||-||-||-||||||--||||-||||||-||||  78 [P]  COG0598 Mg2+ and Co2+ transporters
 9 17 23 32 |||-|-||-|-||--|-||---|-||-|||-|||-||-  64 [S]  COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
 9 16 20 30 -||---||-------||||||-||||-||--||--||-  92 [P]  COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
12 22 28 52 --|||||-|||---|||||||||||||||-|||-|-|- 244 [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
 7 19 28 47 ||||||||||----|-||-|---|||-|||||||||||  61 [O]  COG0602 Organic radical activating enzymes
 6 18 27 43 |||||||||||---|-||-----||--|||||||||||  47 [R]  COG0603 Predicted PP-loop superfamily ATPase
 9 14 21 35 --|||---||-||-|-|-|---|-||-||||||--||- 139 [CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases
12 21 31 54 |-|||---|||||||-|||-||||||-|||||||||||  74 [P]  COG0605 Superoxide dismutase
10 15 22 35 |------|------||||||-|||---|||||||||||  40 [O]  COG0606 Predicted ATPase with chaperone activity
12 22 31 52 |-|||-|-||-||||-||||-|||||-||||||||||| 168 [P]  COG0607 Rhodanese-related sulfurtransferase
12 24 33 54 ||||||||||----||||||||||||-|||||||||||  76 [L]  COG0608 Single-stranded DNA-specific exonuclease
 9 20 27 44 -||||||-|||----|||||--|||||||-|||-|||- 164 [P]  COG0609 ABC-type Fe3+-siderophore transport system, permease component
 4 13 19 27 ||||-||---------|-------||||-|||-|||||  44 [V]  COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
 7 18 25 38 |||||||||||---|-||----|-|--|||||||||--  38 [H]  COG0611 Thiamine monophosphate kinase
11 17 25 43 --------|-|||-||||||-|||||-||||||-||||  91 [R]  COG0612 Predicted Zn-dependent peptidases
 8 15 20 26 ||||--|--||---|||||----||--||-||||----  34 [R]  COG0613 Predicted metal-dependent phosphoesterases (PHP family)
 9 19 26 46 -||||||-|||----|||||--||||-||-|||-|||- 181 [P]  COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component
 7 15 18 22 |||||||||||||||---------||-----------|  26 [MI] COG0615 Cytidylyltransferase
12 22 30 51 |||||||-|-|---|||||||||-|--|||||||||||  89 [OU] COG0616 Periplasmic serine proteases (ClpP class)
12 18 26 49 -----------|||||||||||||||-|||||||||||  75 [J]  COG0617 tRNA nucleotidyltransferase/poly(A) polymerase
11 19 21 33 -|||-||||-|---||||||-||||||---|-------  48 [R]  COG0618 Exopolyphosphatase-related proteins
 9 19 22 38 ||||-|||-||----|||||--|||||-|--|----|-  70 [P]  COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
 9 20 29 46 |||||||||||||-||----|-|-||-||||||||||-  60 [E]  COG0620 Methionine synthase II (cobalamin-independent)
12 24 33 53 |||||||||||---|||||||||||--|||||||||||  90 [J]  COG0621 2-methylthioadenine synthetase
 9 18 23 35 ||||-||||||||--|---|-||||||||-|-------  48 [R]  COG0622 Predicted phosphoesterase
 7 11 17 35 --------------|-|||-|-|-||-||--|||||||  39 [I]  COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)
11 20 30 53 -|--|||||||||-||--|||-||||-||||||||||| 157 [E]  COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases
 4  8 15 26 -----------||---||-------|-|||||||-||| 194 [O]  COG0625 Glutathione S-transferase
 9 17 26 47 --||||--|||||--|--||--||||-||||||||||- 107 [E]  COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases
 5  8 13 28 -----------|----||----|-||-||--|||-||-  52 [R]  COG0627 Predicted esterase
10 20 28 50 ||||-||-------||||||-|||||-||||||||||| 128 [R]  COG0628 Predicted permease
11 18 26 52 -----------||-||||||||||||||||||||||||  82 [L]  COG0629 Single-stranded DNA-binding protein
 3 10 14 21 -||||||-|||------------------|----||||  52 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis
 9 16 18 31 ----|------||-|-|||-|-||||||-|--|-|-|-  55 [T]  COG0631 Serine/threonine protein phosphatase
 9 15 23 48 ---------------|||||||||||||||||||||||  48 [L]  COG0632 Holliday junction resolvasome, DNA-binding subunit
 9 13 19 31 ---|-------||||-|||-|-|----||-||||-|||  69 [C]  COG0633 Ferredoxin
 7 11 18 38 --------------||--||--||||||||||||-||-  39 [F]  COG0634 Hypoxanthine-guanine phosphoribosyltransferase
10 16 24 46 --------------||||||||||||||||||||||||  85 [H]  COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases
14 28 37 65 ||||||||-|||||||||||||||||||||||||||||  77 [C]  COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K
10 18 26 44 --|-||--||-||--||||-|-||||||||||||-||- 109 [R]  COG0637 Predicted phosphatase/phosphohexomutase
 5 13 15 19 ||||||||||||||--------|---------------  79 [O]  COG0638 20S proteasome, alpha and beta subunits
10 22 31 45 -|||||||||||||-|||||---|||-||||||||||- 112 [T]  COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
10 22 31 48 |||||||||||---||||||--||||-||||||||||- 281 [K]  COG0640 Predicted transcriptional regulators
 6 11 12 17 |||---|--|-----|||-----|----|--|----|-  37 [R]  COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)
12 21 29 50 |-||--|----||-||||||||||||-||||||||||| 798 [T]  COG0642 Signal transduction histidine kinase
 7 15 19 31 --||-||--------||||--|-||--||||-|-|||-  46 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases
10 21 27 39 |||||||||||||-||||-|--||---|||--||-||-  98 [C]  COG0644 Dehydrogenases (flavoproteins)
 6  8  9 11 ---|----------|-|||---|----|-------||-  13 [R]  COG0645 Predicted kinase
 7 11 14 27 ---------------|||||--|||--||-|-|--||-  30 [E]  COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain
 9 14 19 35 ---|-||--||||-||---|--|-||-||-----||||  46 [G]  COG0647 Predicted sugar phosphatases of the HAD superfamily
10 18 21 37 ||||||--||||||||----|-|||-|-|-|-------  39 [L]  COG0648 Endonuclease IV
 8 16 23 38 --|||||-|||---|||||---|----|||--||||||  41 [C]  COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7
 5 10 10 15 |||-||-|-|-----|------|-----|---------  23 [C]  COG0650 Formate hydrogenlyase subunit 4
 8 16 21 33 |||||||-|||----||||---|-|--||-|-----||  69 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit
10 18 25 44 |-||-------|||--||||-|||||-||||||||||-  91 [O]  COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
10 16 24 50 --------------||||||||||||||||||||||||  61 [U]  COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase)
 6 10 17 30 -----------||---|||---|-|--|||||||-||| 109 [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
 9 17 23 33 |||---||-|-||-|---||--||||-||||-|--|||  82 [R]  COG0655 Multimeric flavodoxin WrbA
 9 15 20 37 ---|||--||||||-|-|----||||-||---|--||-  96 [R]  COG0656 Aldo/keto reductases, related to diketogulonate reductase
10 17 22 34 --|-|-|--|-||--||||--|||||-||||-|--||- 105 [I]  COG0657 Esterase/lipase
10 16 24 47 --------------||||||||||||||||||||||||  47 [R]  COG0658 Predicted membrane metal-binding protein
 9 14 18 30 --|--------||||-||--|-|-||-||-|||-|-|-  60 [P]  COG0659 Sulfate permease and related transporters (MFS superfamily)
 7 15 22 34 |-|||----|-||---||----|||--|||||||-|||  52 [R]  COG0661 Predicted unusual protein kinase
 8 17 22 34 |||--|||------||||-|--|-|--||||-|||||-  63 [G]  COG0662 Mannose-6-phosphate isomerase
 8 18 24 37 |||-||-|-|----|-|||---|||--||||-||||||  54 [R]  COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily
12 18 25 42 -----------|||||||||||||||-||||||||||- 178 [T]  COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
11 21 30 51 --|||||-|||||-|-|||-||||||-||||||||||- 225 [E]  COG0665 Glycine/D-amino acid oxidases (deaminating)
11 16 23 32 ----|---|--|||--||||-|||---|||||||||||  96 [R]  COG0666 FOG: Ankyrin repeat
12 18 25 38 ---||---|||||-||||||-||-||-||||-|-|||- 153 [C]  COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)
13 25 34 56 |||||||||||-||||||||-|||||-||||-|||||| 141 [M]  COG0668 Small-conductance mechanosensitive channel
 9 15 22 43 --------------||||||-||||||||||||||||-  43 [H]  COG0669 Phosphopantetheine adenylyltransferase
 8 15 22 39 -----------||---||||||-||||||-||||||||  51 [R]  COG0670 Integral membrane protein, interacts with FtsH
12 23 30 49 ||||-|-|-|-||||-||||-|||||-||||||-|||| 120 [I]  COG0671 Membrane-associated phospholipid phosphatase
 9 14 17 24 ------|---|||--|||-|-|--|--||--|-||-||  26 [P]  COG0672 High-affinity Fe2+/Pb2+ permease
10 21 27 43 |-||||-|||-||-|||||---||||-||-|||-|||- 229 [R]  COG0673 Predicted dehydrogenases and related proteins
11 22 26 37 |||||||||||||-||||-|-|||||--|-|---|---  81 [C]  COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit
 9 16 18 25 -|||||-|||----|||||--||-----||----|--- 189 [L]  COG0675 Transposase and inactivated derivatives
 3  3  7 12 -----------|----------|----|||||------  14 [G]  COG0676 Uncharacterized enzymes related to aldose 1-epimerase
 5 10 14 21 ||---|--|------|-------||--||||||---|-  24 [M]  COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase
 3  7 11 16 -----------||---||----------|-||||-||-  20 [O]  COG0678 Peroxiredoxin
 9 17 24 34 ||-----|---||-||||-|--||||-||||||-||||  50 [R]  COG0679 Predicted permeases
 6 13 13 19 |||--|||-|----|-||-----|----|-----|---  37 [C]  COG0680 Ni,Fe-hydrogenase maturation factor
14 28 38 63 ||||||||||||||||||||||||||||||||||||||  93 [U]  COG0681 Signal peptidase I
10 16 24 50 --------------||||||||||||||||||||||||  50 [M]  COG0682 Prolipoprotein diacylglyceryltransferase
 9 15 19 26 -|-|--|-|||----|||||--|-||-||---|-|-|- 112 [E]  COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
 6 12 15 25 |||---||---|------|---|-|--||-|||---|-  34 [H]  COG0684 Demethylmenaquinone methyltransferase
10 18 27 43 --|-||--|||||-|||||---||||-||||||||||-  51 [E]  COG0685 5,10-methylenetetrahydrofolate reductase
 5  8 10 17 ----------------|||---|-||----|---|||-  20 [E]  COG0686 Alanine dehydrogenase
 9 15 22 38 ---|--|-|-|----|||||-|-||||||-||||-||- 114 [E]  COG0687 Spermidine/putrescine-binding periplasmic protein
 8 18 24 40 ||||--||---||-----|||-|||--||||||||-||  45 [I]  COG0688 Phosphatidylserine decarboxylase
11 18 27 44 |---|||||||||||-|-||--|-|--|||||||-|||  49 [J]  COG0689 RNase PH
10 16 24 50 --------------||||||||||||||||||||||||  50 [U]  COG0690 Preprotein translocase subunit SecE
10 16 24 50 --------------||||||||||||||||||||||||  50 [O]  COG0691 tmRNA-binding protein
 9 14 20 42 -----------|||----|||||-|||||||||||-|-  43 [L]  COG0692 Uracil DNA glycosylase
11 24 32 48 -||||||||||||-|-||||-||||||||||||-|||- 110 [R]  COG0693 Putative intracellular protease/amidase
 6 11 17 33 ---|--|----||---||--|---|--|||||--||||  39 [O]  COG0694 Thioredoxin-like proteins and domains
 9 17 25 42 |-||--|----|||-||||---||||-|||||||-|||  82 [O]  COG0695 Glutaredoxin and related proteins
 5 11 13 25 --||---------|--||-----||-|||-|---|-|-  27 [G]  COG0696 Phosphoglyceromutase
14 25 35 57 |-|||||-||||||||||||||||||-||||||||||| 386 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
 7 11 14 31 --------------||-|-|--|||||-|--|--|-||  47 [G]  COG0698 Ribose 5-phosphate isomerase RpiB
 7 11 12 19 -----------|||--|||---|-|--||---|-|---  44 [R]  COG0699 Predicted GTPases (dynamin-related)
 3  5  7 11 -----------------|-----||--||-|-|-----  11 [S]  COG0700 Uncharacterized membrane protein
 7 14 15 21 |||---||------||||----||||--|-----|---  26 [R]  COG0701 Predicted permeases
 8 12 18 28 ---|-------||-|-|||---|-||-||||||--||- 102 [MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases
11 17 24 45 --|--------||-|||||||-||||-||||||||||-  52 [E]  COG0703 Shikimate kinase
10 22 29 47 |||||||||||---|||||--||||||||||-|--||-  82 [P]  COG0704 Phosphate uptake regulator
11 23 31 48 -||||||||||||-|||||--|||||-||||||-|||-  69 [R]  COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
11 18 26 52 -----------||-||||||||||||||||||||||||  62 [U]  COG0706 Preprotein translocase subunit YidC
12 18 26 49 --|----|-|----||||||||||||-|||||||||||  56 [M]  COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase
11 20 28 47 |-|-|-|--|-|||--||||-|||||-|||||||||||  65 [L]  COG0708 Exonuclease III
 4  7 10 15 -|-----|||----|------------||--|--|-|-  15 [E]  COG0709 Selenophosphate synthase
 7 16 18 28 ||||||||||-||-|-----|---||--|----|----  28 [E]  COG0710 3-dehydroquinate dehydratase
 8 14 22 46 --|-----------||||-|--||||||||||||||||  62 [C]  COG0711 F0F1-type ATP synthase, subunit b
 8 15 23 47 -----------||-||||-|--||||||||||||||||  48 [C]  COG0712 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein)
 7 13 18 32 --|||-----|---|-|||---|----|||--||||||  34 [C]  COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)
10 21 27 42 |||||||||||---|||||--||||--||||-|--||- 105 [R]  COG0714 MoxR-like ATPases
10 18 23 33 -||---||---||--||||||-||||-||-|||--||- 112 [P]  COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
 7 16 21 32 |||---||---||---||-|-|-|||-||||||-|---  71 [C]  COG0716 Flavodoxins
 8 20 28 47 |||||||||||---|-||--|-|||--|||-|||||||  53 [F]  COG0717 Deoxycytidine deaminase
 9 15 23 48 ---------------|||||||||||||||||||||||  48 [S]  COG0718 Uncharacterized protein conserved in bacteria
10 20 25 43 |||||||||||----||||-||||||--||-----||-  85 [O]  COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
 7 19 27 43 ||||||||||----||||-----||--|||||||||||  55 [H]  COG0720 6-pyruvoyl-tetrahydropterin synthase
12 23 28 46 ||||--||-||---||||||||||||||----||||||  47 [J]  COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit
 6  9 15 23 -----------||---|-|---|--|-|||||||-||-  40 [E]  COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase
 9 17 24 36 --|||---|||||-|-|||---|||--|-||-||||||  55 [C]  COG0723 Rieske Fe-S protein
 5  8  8  9 -----------|||--||---|--------|---|--- 121 [R]  COG0724 RNA-binding proteins (RRM domain)
 8 20 26 43 |||||||||||---|-|||---|||--||-|||-|||-  52 [P]  COG0725 ABC-type molybdate transport system, periplasmic component
11 20 25 41 --|-||-|---|||-||||||-||||-||||-|-|||- 122 [G]  COG0726 Predicted xylanase/chitin deacetylase
 6 14 18 27 -|||-||-||------|||------|-||||-|-|-|-  43 [R]  COG0727 Predicted Fe-S-cluster oxidoreductase
10 14 21 39 --------------||||||||||---|||||||||||  41 [R]  COG0728 Uncharacterized membrane protein, putative virulence factor
 3  5 11 20 --------------|----|-------|||||||-||-  22 [M]  COG0729 Outer membrane protein
10 22 31 48 |||||||||||---||||||--||||-||||||||||- 153 [R]  COG0730 Predicted permeases
 8 17 19 23 |||||||||||||--|||-|---|----------|---  30 [C]  COG0731 Fe-S oxidoreductases
 5 14 21 35 |||||||---------|-----|-||||||||--||||  88 [V]  COG0732 Restriction endonuclease S subunits
 8 14 16 25 -|||-||-------|----||||-||----||-||---  43 [R]  COG0733 Na+-dependent transporters of the SNF family
11 19 28 48 --|-|-|-|||---||||||-||||||||||||||||-  91 [P]  COG0735 Fe2+/Zn2+ uptake regulation proteins
10 16 21 46 -----------||-||--|||||||||-|-|-||||||  49 [I]  COG0736 Phosphopantetheinyl transferase (holo-ACP synthase)
10 18 21 33 |--|--|----||-||-||--||||||-|-|||-|-|-  69 [F]  COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases
 3  6  9 15 -----------|------------|---||-|-||||-  17 [G]  COG0738 Fucose permease
 9 14 22 42 --------------||||||-|||||-||||||||||| 147 [M]  COG0739 Membrane proteins related to metalloendopeptidases
10 15 23 46 --------------||||||||||||-|||||||||||  84 [OU] COG0740 Protease subunit of ATP-dependent Clp proteases
 6 11 19 37 --------------||||---|-|||-||||||||||| 114 [M]  COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)
 9 15 23 46 ---------------|||||||||||||||||||||||  46 [L]  COG0742 N6-adenine-specific methylase
10 15 21 37 --------------|||||||||||--||||||||||-  37 [I]  COG0743 1-deoxy-D-xylulose 5-phosphate reductoisomerase
 7 12 19 39 ---------------|||||--||||-||||||||||-  91 [M]  COG0744 Membrane carboxypeptidase (penicillin-binding protein)
 9 14 22 43 --------------|||||||-||||-||||||||||| 429 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
 8 19 26 43 |||||||||||---|-|||---|-|--||-|||||||-  45 [H]  COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A
11 20 26 46 --|||||-|||---|||||||-||||-||-|||-|-|- 248 [E]  COG0747 ABC-type dipeptide transport system, periplasmic component
 2  5  7 12 ----------------||---------|--||--|-|-  14 [P]  COG0748 Putative heme iron utilization protein
11 16 24 46 -----------|--||||||||||||-|||||||||||  46 [L]  COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains
12 24 34 58 |||||||||||---||||||||||||-|||||||||||  78 [M]  COG0750 Predicted membrane-associated Zn-dependent proteases 1
 7 11 19 37 --------------||||-||---||-|||||||||||  37 [J]  COG0751 Glycyl-tRNA synthetase, beta subunit
 7 11 19 37 --------------||||-||---||-|||||||||||  37 [J]  COG0752 Glycyl-tRNA synthetase, alpha subunit
 5  9 13 27 -----------||-----|---|-|--||-|||||-|-  37 [P]  COG0753 Catalase
 2  4  6 12 -----------------|----------|--|--|||-  21 [E]  COG0754 Glutathionylspermidine synthase
 8 13 21 38 --|---|-|-|---|-|||---|-|--|||||||||||  42 [O]  COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component
 9 14 21 40 -----------||||----|||||||-|||-|||||||  46 [F]  COG0756 dUTPase
 7 12 17 28 ---------------|||||--|||--||||||-|||-  31 [E]  COG0757 3-dehydroquinate dehydratase II
 9 15 23 42 --------------||||||-|||||||||||||||||  46 [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake
10 15 23 39 --------------||||||||||||-|||||||||||  39 [S]  COG0759 Uncharacterized conserved protein
10 16 24 43 -----------|||||||||-|-|||-||||||||||| 109 [O]  COG0760 Parvulin-like peptidyl-prolyl isomerase
10 15 21 38 --------------|||||||||||--||||||||||-  40 [IM] COG0761 Penicillin tolerance protein
 8 13 18 37 ---------------|||-|||||||-||-|||-|||-  39 [S]  COG0762 Predicted integral membrane protein
 5  9 16 29 --------------|-||-||------|||||||||||  29 [M]  COG0763 Lipid A disaccharide synthetase
 8 13 21 40 --------------|||||||--|||-|||||||||||  69 [I]  COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases
10 16 24 41 --|---|-|-|----||||||-||||-||-|||||||| 191 [E]  COG0765 ABC-type amino acid transport system, permease component
10 15 23 46 --------------||||||||||||-|||||||||||  56 [M]  COG0766 UDP-N-acetylglucosamine enolpyruvyl transferase
 4  8 15 29 --------------|-||----|----|||||||||||  49 [Q]  COG0767 ABC-type transport system involved in resistance to organic solvents, permease component
10 15 23 46 --------------||||||||||||-||||||||||| 107 [M]  COG0768 Cell division protein FtsI/penicillin-binding protein 2
11 17 25 48 |------|------||||||||||||-|||||||||||  63 [M]  COG0769 UDP-N-acetylmuramyl tripeptide synthase
11 19 27 50 |||----|------||||||||||||-|||||||||||  50 [M]  COG0770 UDP-N-acetylmuramyl pentapeptide synthase
11 17 25 48 |------|------||||||||||||-|||||||||||  48 [M]  COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase
10 15 23 46 --------------||||||||||||-|||||||||||  92 [D]  COG0772 Bacterial cell division membrane protein
10 15 23 46 --------------||||||||||||-|||||||||||  60 [M]  COG0773 UDP-N-acetylmuramate-alanine ligase
 5  9 16 29 --------------|-||-||------|||||||||||  29 [M]  COG0774 UDP-3-O-acyl-N-acetylglucosamine deacetylase
 9 14 20 42 --|------------|--|||||||||||-|||||||-  64 [F]  COG0775 Nucleoside phosphorylase
11 17 25 51 ----|---------|||||||||||||||||||||||| 112 [L]  COG0776 Bacterial nucleoid DNA-binding protein
 8 13 20 39 --------------|-|||||-||||-||||||||||-  40 [I]  COG0777 Acetyl-CoA carboxylase beta subunit
10 22 31 50 |||||||||||---||||||--||||-||||||||||- 161 [C]  COG0778 Nitroreductase
 9 14 22 42 --------------||||||-|||||-|||||||||||  42 [S]  COG0779 Uncharacterized protein conserved in bacteria
 6 10 19 33 --------|-|---||||------||-|||||||||||  34 [R]  COG0780 Enzyme related to GTP cyclohydrolase I
10 16 24 50 --------------||||||||||||||||||||||||  50 [K]  COG0781 Transcription termination factor
 7 12 20 46 ---------------|--|-||||||||||||||||||  83 [K]  COG0782 Transcription elongation factor
 8 13 20 35 ---|------------||||-||-|||||||||-||||  41 [P]  COG0783 DNA-binding ferritin-like protein (oxidative damage protectant)
10 20 25 40 |-||-||----|||-||||--||||--||||||-|||- 545 [T]  COG0784 FOG: CheY-like receiver
11 17 19 30 |-|--||-|-|---||||||-||-||-----|--|-|-  44 [O]  COG0785 Cytochrome c biogenesis protein
 5  7 10 16 -----------------|-|--|-|--||-||-||---  19 [E]  COG0786 Na+/glutamate symporter
 9 14 22 43 ------------|-|-||||-|||||-|||||||||||  58 [M]  COG0787 Alanine racemase
 7 11 16 27 ---|----------|-|||---|-|--||||||-|||-  34 [F]  COG0788 Formyltetrahydrofolate hydrolase
 8 14 22 42 --|---|-------|-||||--||||-||||||||||| 178 [K]  COG0789 Predicted transcriptional regulators
 4  8 13 24 -----------|||----|--------||-|||||||-  93 [R]  COG0790 FOG: TPR repeat, SEL1 subfamily
 6 11 18 35 ----------------|||-|-||||-||||||||||- 123 [M]  COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
 9 13 19 33 --------------||||||-|||---||||||||||-  33 [L]  COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase
11 16 24 42 ----|---||----||||||||-||--|||||||||||  56 [M]  COG0793 Periplasmic protease
 7 16 25 41 |||--||||||---|----||--||--|||||||||||  51 [M]  COG0794 Predicted sugar phosphate isomerase involved in capsule formation
 7 11 18 32 ---------------|||||||-----|||||||||||  66 [R]  COG0795 Predicted permeases
 8 13 19 40 --------------|-||||-|||||-||-|||||||-  41 [M]  COG0796 Glutamate racemase
 5  9 16 29 --------------|-||---|-|---|||||||||||  36 [M]  COG0797 Lipoproteins
 7 14 14 17 |-|--||----|---|||----|||------|-|--|-  22 [P]  COG0798 Arsenite efflux pump ACR3 and related permeases
 9 13 21 43 --------------|||||-|||-||-|||||||||||  43 [S]  COG0799 Uncharacterized homolog of plant Iojap protein
 5 10 17 30 ---------------|||---|-|||-||||||||||-  40 [G]  COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase
10 16 24 44 -----------||-|||||||-||||-|||||||||||  48 [H]  COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
10 16 24 46 --------------||||||||||||||||||||||||  46 [R]  COG0802 Predicted ATPase or kinase
12 21 26 42 |-||-||-|-|---||||||||||||-||--|-||-||  68 [P]  COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
 6 11 13 23 ------------|---|||---|-|-|||--||-|-|-  25 [E]  COG0804 Urea amidohydrolase (urease) alpha subunit
 8 15 24 43 --|||-|-|||---|-|||---|-|--|||||||||||  49 [U]  COG0805 Sec-independent protein secretion pathway component TatC
 9 14 22 44 --------------||||||-|||||-|||||||||||  44 [J]  COG0806 RimM protein, required for 16S rRNA processing
11 18 25 45 ----|-|----||-|||||||-||||-||||||||||-  56 [H]  COG0807 GTP cyclohydrolase II
 8 13 21 39 --------------||||||-|-|||-|||||||||||  41 [J]  COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)
 4  7 13 24 --------------|-|--|-------||||||||||-  40 [M]  COG0810 Periplasmic protein TonB, links inner and outer membranes
 7 13 20 33 |-|----|------|-|||||------|||||||||||  71 [U]  COG0811 Biopolymer transport proteins
10 15 23 46 --------------||||||||||||-|||||||||||  48 [M]  COG0812 UDP-N-acetylmuramate dehydrogenase
 6  9 12 26 ---------|--------||-|--|||-|-||--|-|-  28 [F]  COG0813 Purine-nucleoside phosphorylase
 5  8 11 20 -----------|||------|-|----||-||-||---  75 [E]  COG0814 Amino acid permeases
 8 12 18 35 --------------|||||-|||----||-||||||||  39 [M]  COG0815 Apolipoprotein N-acyltransferase
 9 15 23 47 --------------|||||||-||||||||||||||||  47 [L]  COG0816 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis)
 8 12 19 35 ---------------||||||||----|||||||||||  35 [L]  COG0817 Holliday junction resolvasome, endonuclease subunit
 5 10 16 32 ---------------||||----|||-||||||||-|-  35 [M]  COG0818 Diacylglycerol kinase
 7 11 14 23 ----||--|||||---|-----|-||-----|--|-|-  31 [K]  COG0819 Putative transcription activator
 9 15 22 41 --------------||||||-||||||||||||||||-  46 [R]  COG0820 Predicted Fe-S-cluster redox enzyme
10 15 21 38 --------------|||||||||||--||||||||||-  38 [I]  COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis
12 20 27 53 --||--|----||||||--||||||||||-||||||||  60 [C]  COG0822 NifU homolog involved in Fe-S cluster formation
 4  9 15 27 --|---|---------||--|------||||||-||||  38 [U]  COG0823 Periplasmic component of the Tol biopolymer transport system
10 18 26 43 |-|||---|||---|-||||-||||--||||||||||-  80 [R]  COG0824 Predicted thioesterase
 8 13 20 39 --------------|-|||||-||||-||||||||||-  40 [I]  COG0825 Acetyl-CoA carboxylase alpha subunit
 8 15 20 35 |||----|-|----|-|-||---|||-||-|||||-|-  75 [O]  COG0826 Collagenase and related proteases
 4  7  8 17 -|--------------------||||-----|--|-|-  22 [L]  COG0827 Adenine-specific DNA methylase
 6 12 20 42 --------------|-||--||-|||||||||||||||  46 [J]  COG0828 Ribosomal protein S21
 6 11 13 19 ------------|---|||---|-|-|||--||-|-|-  21 [O]  COG0829 Urease accessory protein UreH
 6 11 13 22 ------------|---|||---|-|-|||--||-|-|-  24 [O]  COG0830 Urease accessory protein UreF
 6 11 13 23 ------------|---|||---|-|-|||--||-|-|-  25 [E]  COG0831 Urea amidohydrolase (urease) gamma subunit
 6 11 13 22 ------------|---|||---|-|-|||--||-|-|-  24 [E]  COG0832 Urea amidohydrolase (urease) beta subunit
 3  7  9 16 -----------||----------|||-||---|-|---  54 [E]  COG0833 Amino acid transporters
11 17 25 46 --|---|-|-|----|||||||||||-||-|||||||| 270 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
 6 14 18 30 --||-||--------|||---|-||--||||-|-|||-  76 [NT] COG0835 Chemotaxis signal transduction protein
 7 13 18 27 --||-||-------|||||----|---||||---||||  37 [M]  COG0836 Mannose-1-phosphate guanylyltransferase
 2  6 10 19 ----------------||---------|||--|||||-  21 [G]  COG0837 Glucokinase
 7 14 21 35 --|||-|-|||---|-|||---|----|||--||||||  38 [C]  COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A)
 7 14 20 34 --|||-|--||---|-|||---|----|||--||||||  40 [C]  COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J)
 7 15 19 31 --||-||--------||||--|-||--||||-|-|||- 323 [NT] COG0840 Methyl-accepting chemotaxis protein
 9 14 21 35 --|-----------||||||-|-||--||||||||||| 149 [V]  COG0841 Cation/multidrug efflux pump
10 22 30 48 |-||||||||||||-||||---||||-||||||-|||- 200 [V]  COG0842 ABC-type multidrug transport system, permease component
 9 12 18 33 ---|----||||--|-|||---|-|--|||--|--|||  60 [C]  COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1
 9 14 22 39 --------------||||||-|||||-||||||||||| 288 [M]  COG0845 Membrane-fusion protein
11 19 25 38 -----|||||||||||--||--|||||||-|||-||--  49 [K]  COG0846 NAD-dependent protein deacetylases, SIR2 family
12 18 26 47 ----|-|----|||||-||-||||||-|||||||||||  95 [L]  COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases
 6 10 17 30 --------------|-|||||------|||||||||||  65 [U]  COG0848 Biopolymer transport protein
 8 12 20 39 -------|------||--||-|-|||-|||||||||||  42 [D]  COG0849 Actin-like ATPase involved in cell division
 7 12 17 29 --------------||||||---||--||||||||-|-  29 [D]  COG0850 Septum formation inhibitor
 4  8 12 22 ----------------||||-------||||-|||-|-  22 [D]  COG0851 Septum formation topological specificity factor
 8 16 23 38 --|||||-|||---|||||---|----|||--||||||  40 [C]  COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit
 7 12 16 30 --------------|||||---|||--|||--|||||-  31 [H]  COG0853 Aspartate 1-decarboxylase
 3  7 12 22 --------------|-||---------||||-|||||-  22 [H]  COG0854 Pyridoxal phosphate biosynthesis protein
 6 11 16 28 --|-------------|||---|||--||||-|||||-  28 [P]  COG0855 Polyphosphate kinase
 1  6  6  7 |||||-|-------------------------------   8 [F]  COG0856 Orotate phosphoribosyltransferase homologs
 5  9 12 22 ---|--|---------|||---|----||-||-||---  23 [R]  COG0857 BioD-like N-terminal domain of phosphotransacetylase
10 16 24 50 --------------||||||||||||||||||||||||  50 [J]  COG0858 Ribosome-binding factor A
 4  8 14 22 --------------|-||-|-------||||||||||-  70 [M]  COG0859 ADP-heptose:LPS heptosyltransferase
 9 14 20 40 --------------|-|||||||||--||||||||||-  85 [M]  COG0860 N-acetylmuramoyl-L-alanine amidase
 5 10 17 35 ----------------|||---|||--|||||||||||  74 [P]  COG0861 Membrane protein TerC, possibly involved in tellurium resistance
 7 13 19 29 -|-|||---------||-||----||--|||||||||-  63 [L]  COG0863 DNA modification methylase
 4 13 16 23 ||||-||||||------------||---|-----|||-  30 [K]  COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain
 5 11 11 18 |||---||----------|--|-||---|-------|-  25 [F]  COG1001 Adenine deaminase
 7 15 16 21 -||||---|---------|--||||-|-|--|-|||--  39 [V]  COG1002 Type II restriction enzyme, methylase subunits
10 16 21 35 ---|||---||||-|||||---|-|--|||--||-||-  36 [E]  COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain
 7 15 22 33 -|||-||--|----|-||----|-||-||||||-||||  44 [M]  COG1004 Predicted UDP-glucose 6-dehydrogenase
 7 14 21 35 --|||-|-|||---|-|||---|----|||--||||||  38 [C]  COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H)
 7 13 15 22 ||||-|---------||||---|-|--|--|-----||  33 [P]  COG1006 Multisubunit Na+/H+ antiporter, MnhC subunit
 7 14 21 35 --|||-|-|||---|-|||---|----|||--||||||  37 [C]  COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N)
 6 12 17 31 --|||---------|-|||---|----|||--||||||  40 [C]  COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M)
 8 16 24 42 --|||||-|||---|-|||---|-|--||||-||||||  65 [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit
 7 17 19 24 |||||-||||------||-|--|||--||---|---|-  25 [H]  COG1010 Precorrin-3B methylase
11 20 27 44 ||||-|-|||-|||-||-|--|||||-||-||||-||- 134 [R]  COG1011 Predicted hydrolase (HAD superfamily)
10 22 31 50 |||||--||||||-|-||||--|||||||-|||||||| 358 [C]  COG1012 NAD-dependent aldehyde dehydrogenases
11 22 26 37 |||||||||||||-||||-|-|||||--|-|---|---  79 [C]  COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit
10 22 27 38 |||||||||||---||||-|-|||||--|-|-|-|||-  89 [C]  COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit
 4  8 10 23 ---------------|--|----||||-|-|---|-|-  25 [G]  COG1015 Phosphopentomutase
 6 10 13 19 -----------||-|---|---|-|--||||-|-|-|-  19 [C]  COG1017 Hemoglobin-like flavoprotein
 7 10 15 28 ---|-------||-----||--|-|--||||-||-||-  78 [C]  COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1
 3 11 11 13 |||||||||--||-------------------------  13 [R]  COG1019 Predicted nucleotidyltransferase
 5  9 12 25 -----------||---|-----|-||-||-|-|-|-|- 145 [Q]  COG1020 Non-ribosomal peptide synthetase modules and related proteins
 3  4  6 11 ----------------------|-|--||-|-----|-  11 [Q]  COG1021 Peptide arylation enzymes
10 13 17 22 ---|--|-|-|||||-||-|-||----||-||------  36 [I]  COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
 6  6  7 10 ---|----------|---|---|-||----------|-  10 [G]  COG1023 Predicted 6-phosphogluconate dehydrogenase
10 16 24 39 ---||-|-|||||-|-|-||--||||-||||-|--||| 245 [I]  COG1024 Enoyl-CoA hydratase/carnithine racemase
 4  5  7 12 -----------|||------|------||-|-------  13 [O]  COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like
 5  6  6  8 -----------||-----|-||-|--------------  11 [R]  COG1026 Predicted Zn-dependent peptidases, insulinase-like
 6 10 13 24 ----|----------||-----|||--||-||-||-|-  25 [E]  COG1027 Aspartate ammonia-lyase
13 23 33 57 --|||||-|||||||||||||-||||-||||||||||| 825 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
 1  5  5  5 |||---||------------------------------  12 [C]  COG1029 Formylmethanofuran dehydrogenase subunit B
 5 10 11 16 --|-|||-|-|---|---------|--|----|---|-  18 [O]  COG1030 Membrane-bound serine protease (ClpP class)
 3  8  9 10 -|||-||||-|----|----------------------  10 [C]  COG1031 Uncharacterized Fe-S oxidoreductase
 9 18 23 29 |||-|||||||----|||||--||||-||-|-----|-  87 [C]  COG1032 Fe-S oxidoreductase
 5 11 11 13 -|||-|||-------|-----|--|--|------|---  19 [R]  COG1033 Predicted exporters of the RND superfamily
 7 11 16 29 --------------|||||---||---|||--||||||  30 [C]  COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)
 3  8  8  8 |||---||--------||------------------|-  22 [C]  COG1035 Coenzyme F420-reducing hydrogenase, beta subunit
 1  5  5  5 |||---||------------------------------   8 [C]  COG1036 Archaeal flavoproteins
 4  6  7 15 -----------||---------||||----------|-  16 [C]  COG1038 Pyruvate carboxylase
 3  4  5 13 --------------|-----|---|||-----------  13 [L]  COG1039 Ribonuclease HIII
 9 14 22 40 --------------||||||-|||||-|||||||||||  43 [R]  COG1040 Predicted amidophosphoribosyltransferases
 3 11 13 15 |||||||||||||-------------------------  17 [L]  COG1041 Predicted DNA modification methylase
 4 12 15 23 -|||||||||------|----------||-|--|--|-  47 [C]  COG1042 Acyl-CoA synthetase (NDP forming)
 5  9 16 29 --------------|-||-||------|||||||||||  29 [M]  COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase
 5  9 16 29 --------------|-||-||------|||||||||||  33 [M]  COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
 7 13 19 39 --||--------|--|||----||||-||-|||||||-  53 [E]  COG1045 Serine acetyltransferase
 6 15 22 32 |||||||||||-------||-|-----||||||||---  44 [O]  COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
 8 14 23 38 --|||---|||||-|---|---||||-||||-||-|||  48 [C]  COG1048 Aconitase A
 2  6 11 18 ----------------||---------||||||||-|-  18 [C]  COG1049 Aconitase B
 8 17 24 34 |||--||||||---|-|||---||||-||-|-|--|||  56 [F]  COG1051 ADP-ribose pyrophosphatase
 9 16 24 40 ----||--|||||-|-||-|-|-|||-||-|||||||-  92 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases
12 23 33 53 ||-||-|||||||-|||||||-||||-|||||||||||  83 [C]  COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
 6  9 15 29 ----------------|||-|-|-||-||||-|--|||  29 [R]  COG1054 Predicted sulfurtransferase
 9 15 20 33 ----|||-|||----|||-||-|-|--||-|-|||-|-  44 [P]  COG1055 Na+/H+ antiporter NhaD and related arsenite permeases
 7 14 17 25 |||||||-|||------||---|--|--|--||-----  29 [H]  COG1056 Nicotinamide mononucleotide adenylyltransferase
 9 16 22 45 -----------||-||||-|-||||||||||-|||||-  50 [H]  COG1057 Nicotinic acid mononucleotide adenylyltransferase
10 17 23 39 ---||||-||||---|||||--||||--|-|-||-||-  40 [R]  COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA
 5  7  7  8 -|--|-|--|----||---|------------------   8 [L]  COG1059 Thermostable 8-oxoguanine DNA glycosylase
11 20 22 32 |||||-|||-|---|||||||-|||---|-|---|---  57 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes
11 17 21 32 --|||||-||||||--|-||-|||||--|-|-------  64 [KL] COG1061 DNA or RNA helicases of superfamily II
 6 10 14 25 ---------|-||---||----|-|--||--|||-||-  42 [C]  COG1062 Zn-dependent alcohol dehydrogenases, class III
 9 18 26 41 --|||||--||||--||-|---||||||||||||-||- 159 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
 7 13 19 36 --|-|---|||||---||----|-||-|||--|||-|-  83 [R]  COG1064 Zn-dependent alcohol dehydrogenases
10 15 23 42 --------------||||||||||||-|||||||||||  43 [O]  COG1066 Predicted ATP-dependent serine protease
 5 13 16 24 ||||||||-------|-----|-||--||-||------  32 [O]  COG1067 Predicted ATP-dependent protease
 3  4  4 13 -----------|------------|---|-------|-  17 [C]  COG1069 Ribulose kinase
 9 14 17 32 ------|---|||--|||---|||||-||--||---|-  90 [G]  COG1070 Sugar (pentulose and hexulose) kinases
10 16 21 35 ---||---||||||--|||-|-|-||||----|--|||  58 [C]  COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
 5  7 10 25 ----|------||---------|-||--|-||----|-  33 [H]  COG1072 Panthothenate kinase
12 19 25 38 --||-||---||||-||-|||-||||-||||||--||-  89 [R]  COG1073 Hydrolases of the alpha/beta superfamily
 6 10 18 39 -------------------|||||||-|||||||||||  39 [L]  COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)
 7 12 14 16 ------|----||---|||---|||-||-||-|-----  24 [R]  COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold
 4  8 14 25 -----------|||---|---------||-||||||||  37 [O]  COG1076 DnaJ-domain-containing proteins 1
 9 16 21 34 |---|-||------|||--|||-||--||||||-||-|  43 [D]  COG1077 Actin-like ATPase involved in cell morphogenesis
 7 15 18 27 |||||||||||--|||---|----|||-----------  34 [R]  COG1078 HD superfamily phosphohydrolases
 8 14 16 27 ---|-||-|-|----||-|--|-|||||----|---|-  42 [R]  COG1079 Uncharacterized ABC-type transport system, permease component
 7 11 18 33 ------------------||||||||||||||||-||-  49 [G]  COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)
 7 16 19 33 |||--|||-|-----|||----||||-||---|--||- 115 [G]  COG1082 Sugar phosphate isomerases/epimerases
 3  5  5  7 --|--------------|-------------|-||---   9 [M]  COG1083 CMP-N-acetylneuraminic acid synthetase
 4 12 14 16 ||||||||||||||------------------------  16 [R]  COG1084 Predicted GTPase
 7 11 13 19 --|--||-|--||--|------||-|--|-||------  21 [C]  COG1085 Galactose-1-phosphate uridylyltransferase
 7 11 18 26 -|-------------|---|-|||||-|-|||||||||  34 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases
 9 16 22 37 |----------||-|-||||--|||||||-|||||||-  54 [M]  COG1087 UDP-glucose 4-epimerase
 9 17 24 38 |-|-|||--||-|---||||--||||-|||-|||-||-  45 [M]  COG1088 dTDP-D-glucose 4,6-dehydratase
 6 11 15 22 |-|---|-------|-||----||---||||---|||-  29 [M]  COG1089 GDP-D-mannose dehydratase
 5  6  9 21 ----|-----------||----|-|--|||-|------  21 [R]  COG1090 Predicted nucleoside-diphosphate sugar epimerase
 9 18 25 36 |-|||||--||---|-||||--||||-|||--||-|||  44 [M]  COG1091 dTDP-4-dehydrorhamnose reductase
 9 13 19 35 -|---|-|--|---||--|||---||-|||||||--|-  48 [R]  COG1092 Predicted SAM-dependent methyltransferases
 4 12 14 16 ||||||||||||||------------------------  16 [J]  COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)
 4 12 14 16 ||||||||||||||------------------------  19 [R]  COG1094 Predicted RNA-binding protein (contains KH domains)
 4 12 14 16 ||||||||||||||------------------------  19 [K]  COG1095 DNA-directed RNA polymerase, subunit E'
 3  9 11 13 |-|-|||||||||-------------------------  13 [J]  COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain)
 4 10 12 14 |-|-||||||||||------------------------  17 [J]  COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)
 3  4  5 10 ---------------|--|----|||------------  14 [J]  COG1098 Predicted RNA binding protein (contains ribosomal protein S1 domain)
 2  5  5  5 ||----||--------|---------------------   7 [R]  COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold
 8 17 19 21 |||||||||||||||-|||-----------------|- 114 [R]  COG1100 GTPase SAR1 and related small G proteins
 4  6  8 13 -------------------|--|--|-|--|-|---||  13 [R]  COG1101 ABC-type uncharacterized transport system, ATPase component
 3 10 12 15 |||||||||||----------|----------------  15 [F]  COG1102 Cytidylate kinase
 1  5  5  5 |||---||------------------------------   6 [R]  COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes
13 20 27 49 --|---|----|||||||||||||||-||-||||||||  76 [E]  COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes
 7 10 14 27 ---------------|--||-||||||||-|||-----  38 [G]  COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)
 5  6  6  8 -|---|---|------|--|--------------|---  14 [R]  COG1106 Predicted ATPases
 1  7  7  8 ||||-|||------------------------------   9 [L]  COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain
12 21 27 47 |-||-||-|-|---||||||||||||-||-||-||-||  81 [P]  COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
14 28 38 65 |||||||||||||||||||||||||||||||||||||| 147 [G]  COG1109 Phosphomannomutase
 4  7  9 10 -|---||||||---||----------------------  16 [L]  COG1110 Reverse gyrase
 2 10 10 12 ||||||||---||-------------------------  13 [L]  COG1111 ERCC4-like helicases
11 23 25 34 ||||||||-|-|||||-|-|--|||-||||----|--|  60 [L]  COG1112 Superfamily I DNA and RNA helicases and helicase subunits
 3  5  7 19 ----------------------||||-||-------|-  77 [E]  COG1113 Gamma-aminobutyrate permease and related permeases
 6  7 11 19 -------------------|||||||-||-||------  24 [E]  COG1114 Branched-chain amino acid permeases
 8 12 16 29 --|--|------------|||||-||-||-||-||-|-  57 [E]  COG1115 Na+/alanine symporter
10 18 24 35 -||-|-||||-----||||||-||||-|||-||--||-  90 [P]  COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component
10 22 30 48 ||||-||||||---|||||--||||||||||||-|||-  64 [P]  COG1117 ABC-type phosphate transport system, ATPase component
 4  8 13 24 ----------------||----|-|--||||-|||||-  34 [P]  COG1118 ABC-type sulfate/molybdate transport systems, ATPase component
 6  7  9 19 --|--------||-----|---|-||--|--|------  20 [P]  COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA
 9 20 26 44 -||||||--||----|||||--|||||||-|||-|||- 118 [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components
12 21 28 47 |-||-||-|||---||||||||||||-||-||-||-||  70 [P]  COG1121 ABC-type Mn/Zn transport systems, ATPase component
10 21 26 42 ||||-||||||----|||||-||||||-|-|||---|- 102 [P]  COG1122 ABC-type cobalt transport system, ATPase component
 7 15 16 26 |||-|--|-|------||-|--|-|---|-|-|-|-|-  72 [R]  COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase
 5  8  9 19 --|-|--------------||---|||-|-------|-  28 [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
 7 10 12 25 ------|---------|-||--||||-||-----|-|-  31 [E]  COG1125 ABC-type proline/glycine betaine transport systems, ATPase components
10 16 24 41 --|---|-|-|----||||||-||||-||-|||||||| 130 [E]  COG1126 ABC-type polar amino acid transport system, ATPase component
 4  8 15 29 --------------|-||----|----|||||||||||  35 [Q]  COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component
 6  9 14 24 ---------------|---|-||-|||||-|||--||- 168 [G]  COG1129 ABC-type sugar transport system, ATPase component
11 24 33 54 |-||||||||||||-||||--||||||||||||||||- 323 [V]  COG1131 ABC-type multidrug transport system, ATPase component
13 22 31 57 --||-|--||-||||||||||-|||||||||||||||| 302 [V]  COG1132 ABC-type multidrug transport system, ATPase and permease components
 1  3  3  9 ----------------------------|-----|-|-   9 [I]  COG1133 ABC-type long-chain fatty acid transport system, fused permease and ATPase components
 6 12 19 30 --|---|-------|-||----||||-|||||-|||||  38 [GM] COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component
 8 13 20 36 ----------------||||||||||-||||||||||-  41 [P]  COG1135 ABC-type metal ion transport system, ATPase component
12 23 33 58 ||||--|||||---|||||||||||||||||||||||| 228 [V]  COG1136 ABC-type antimicrobial peptide transport system, ATPase component
 8 12 19 33 --------------||||||||-----|||||||||||  33 [R]  COG1137 ABC-type (unclassified) transport system, ATPase component
 4  6 13 22 --|---|-|-|-------|--------|||||---|||  29 [O]  COG1138 Cytochrome c biogenesis factor
 6 11 16 23 |--||-|-|||-------||----||--|--||||---  24 [C]  COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain
 4  6  8 14 --------|-|-----------|-|--||---|---|-  18 [C]  COG1140 Nitrate reductase beta subunit
 6 11 13 19 |--|-||-|-|----|||----||||------------  27 [C]  COG1141 Ferredoxin
 4 10 10 15 |||--|||-------|||----------|---------  45 [C]  COG1142 Fe-S-cluster-containing hydrogenase components 2
 8 18 25 40 |||||||-|||---|||||---|----|||--||||||  52 [C]  COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)
 5 11 12 15 |||-||||||----||------------------|---  22 [C]  COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit
 8 19 26 38 |||-|||||||----|||||---||--||||||||-|- 184 [C]  COG1145 Ferredoxin
 8 19 25 38 ||||||||||-----||||---||---||||-|-||||  84 [C]  COG1146 Ferredoxin
 4  8  8  8 |||---||-|----||----------------------  13 [C]  COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins
 2  7  7  8 |||--|||-------|----------------------  16 [C]  COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain
 3  7  7  7 |||---||-|----|-----------------------  11 [C]  COG1150 Heterodisulfide reductase, subunit C
 5 10 10 14 |||--|||-------|---|---|----|---------  19 [C]  COG1151 6Fe-6S prismane cluster-containing protein
 1  5  5  5 |||---||------------------------------  10 [C]  COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit
 1  5  5  5 |||---||------------------------------   9 [C]  COG1153 Formylmethanofuran dehydrogenase subunit D
10 15 22 40 --------------||||||||||||-||||||||||-  44 [HI] COG1154 Deoxyxylulose-5-phosphate synthase
 9 17 19 24 ||||||||||||||----||||---|------------  31 [C]  COG1155 Archaeal/vacuolar-type H+-ATPase subunit A
 9 17 19 24 ||||||||||||||----||||---|------------  26 [C]  COG1156 Archaeal/vacuolar-type H+-ATPase subunit B
 6 10 13 27 --------------||----||-||--||-|-|-|||-  41 [NU] COG1157 Flagellar biosynthesis/type III secretory pathway ATPase
 9 13 20 41 --------------||--|||||||--|||||||||||  41 [K]  COG1158 Transcription termination factor
 9 15 23 48 --------------||||||-|||||||||||||||||  48 [R]  COG1159 GTPase
10 16 24 50 --------------||||||||||||||||||||||||  52 [R]  COG1160 Predicted GTPases
10 18 21 31 -||--|-|||||||-|||-|-|-||||---|--|----  51 [R]  COG1161 Predicted GTPases
 9 14 20 37 --|-----------||||-|-|||||||||||||--|-  40 [R]  COG1162 Predicted GTPases
 4 12 14 16 ||||||||||||||------------------------  19 [R]  COG1163 Predicted GTPase
 8 12 14 29 --||-----------|--||||--|||---|---|||-  41 [E]  COG1164 Oligoendopeptidase F
 5  6  9 19 ---|------------||----|-||--|-||------  19 [H]  COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
 3  6 10 17 ----------------|||--------|||||-||---  18 [E]  COG1166 Arginine decarboxylase (spermidine biosynthesis)
10 15 22 38 ----||--|||||--||-||--||||-||-|||--||- 107 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
 5  7  9 19 ------------------||--||||--|--||-----  21 [E]  COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
 5  7 11 21 ---|------------||----|-||-||-||----|-  27 [HQ] COG1169 Isochorismate synthase
10 16 26 44 ---||---|||||--|||||--|-||-|||||||||||  75 [E]  COG1171 Threonine dehydratase
 5  7 12 22 ---------------|---|--|-||-||-|||--||- 175 [G]  COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components
12 22 28 51 --|||||-|||---|||||||||||||||-|||-|-|- 241 [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
 7 11 13 26 ------|---------|-||--||||-||---|-|-|-  54 [E]  COG1174 ABC-type proline/glycine betaine transport systems, permease component
 9 16 23 42 ---|||--|||----||||--||||||||||||---|- 219 [G]  COG1175 ABC-type sugar transport systems, permease components
 9 14 21 37 ---|--|-|-|----||-||-|-||||||-||||-||-  88 [E]  COG1176 ABC-type spermidine/putrescine transport system, permease component I
 9 15 22 38 ---|--|-|-|----||-||-|-||||||-|||||||-  98 [E]  COG1177 ABC-type spermidine/putrescine transport system, permease component II
 9 14 20 30 ---|-|--|-|-----||||-||-||-||-|||||-|-  65 [P]  COG1178 ABC-type Fe3+ transport system, permease component
 4  8 13 23 -----------||------|---||--||||||||---  24 [H]  COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
 8 16 22 33 |||-|||||||---||---|--||||-||-|||-----  70 [O]  COG1180 Pyruvate-formate lyase-activating enzyme
11 16 24 46 --|-----------||||||||||||-|||||||||||  65 [M]  COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes
 3  7 10 21 ----------------|------||||||--||---|-  29 [I]  COG1182 Acyl carrier protein phosphodiesterase
 8 18 21 32 ||||--||---||------||||||--|-|--|||-||  39 [I]  COG1183 Phosphatidylserine synthase
 4 10 11 13 -||||||-|-|||--|----------------------  20 [J]  COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
11 17 25 48 -----------||-||||||||||||-|||||||||||  48 [J]  COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)
11 17 25 47 -----------||-||||||||||||-|||||||||||  66 [J]  COG1186 Protein chain release factor B
10 16 24 47 --------------||||||||||||||||||||||||  99 [J]  COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases
 5  9 15 31 ---------------|---|--||||-||-|||||||-  32 [J]  COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
 9 14 17 31 --|---|-------||||-|-||||||-------||||  31 [J]  COG1189 Predicted rRNA methylase
13 20 27 49 --|-----||-||||||||||-|||||||||||||-|-  59 [J]  COG1190 Lysyl-tRNA synthetase (class II)
 8 12 14 25 --------------||||--|||||--||-|-|-|---  45 [K]  COG1191 DNA-directed RNA polymerase specialized sigma subunit
10 21 28 48 ||-|||-|||----|-|||-|||||-|||||-|||||| 148 [D]  COG1192 ATPases involved in chromosome partitioning
 9 14 15 23 |-||-|--------||||||-|-|||--------|---  26 [L]  COG1193 Mismatch repair ATPase (MutS family)
 9 14 22 43 |--|----|-|-|-----|-||||||-||||||||||-  44 [L]  COG1194 A/G-specific DNA glycosylase
 9 12 19 36 --------|-------||||||||||-|||||---|||  36 [L]  COG1195 Recombinational DNA repair ATPase (RecF pathway)
12 23 26 44 -||||||----|||||||||-|||||||-|---|-||-  60 [D]  COG1196 Chromosome segregation ATPases
 9 14 22 45 ---------------|||||||||||-|||||||||||  45 [LK] COG1197 Transcription-repair coupling factor (superfamily II helicase)
10 15 23 46 --------------||||||||||||-|||||||||||  47 [L]  COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase
10 20 28 43 ||||||--|||||||-||-|--||||-|||||||-|--  61 [KL] COG1199 Rad3-related DNA helicases
 9 14 22 43 --------------||||||-|||||-|||||||||||  43 [LK] COG1200 RecG-like helicase
 5 14 18 27 |||||||||||-----|-----|----||---|--||-  38 [R]  COG1201 Lhr-like helicases
 1  6  6  7 ||||-|-|------------------------------   7 [R]  COG1202 Superfamily II helicase, archaea-specific
 7 11 15 20 |||--||-|||---||---|----||--|--|------  28 [R]  COG1203 Predicted helicases
 6 15 17 20 |||||||||||||||-------------|-------|-  26 [R]  COG1204 Superfamily II helicase
 8 15 16 21 |||--|||||-||---|-|---|-|---|-------|-  27 [R]  COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
 7  8 10 18 --------------||||||----||---------||-  18 [J]  COG1206 NAD(FAD)-utilizing enzyme possibly involved in translation
 8 13 21 42 --------------||||||--||||-|||||||||||  42 [M]  COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)
10 23 29 40 |||||||||||||||-|||---|||--|||--|||||-  90 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)
 8 17 23 37 |-|||||--||----||||---||||-|||--||-||-  48 [M]  COG1209 dTDP-glucose pyrophosphorylase
 9 17 24 44 |||--|---|----|-|--|-||||||||||||||||-  61 [M]  COG1210 UDP-glucose pyrophosphorylase
11 17 24 44 -----|--------|||||||||||||||||||||||-  46 [I]  COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase
 4  7 14 27 --------------|----||------|||||||||||  27 [M]  COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase
 5  9  9 10 |----||---|---|----|-------|------||--  11 [M]  COG1213 Predicted sugar nucleotidyltransferases
10 16 24 50 --------------||||||||||||||||||||||||  50 [O]  COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone
 9 19 24 37 |-|-||||||-||||-||----||||-||---|--|||  82 [M]  COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
 7 14 18 25 |-|-|||---|-----|||---||---|||-||--||-  54 [R]  COG1216 Predicted glycosyltransferases
 6 11 19 40 ----------------||||--||||-|||||||||||  40 [T]  COG1217 Predicted membrane GTPase involved in stress response
 6 10 16 30 -----------||-|-||--|-|----|||||--||||  31 [P]  COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase
11 16 24 47 -----------|--||||||||||||-|||||||||||  47 [O]  COG1219 ATP-dependent protease Clp, ATPase subunit
 5  8 14 29 --------------||-----|--|--||||||-||||  29 [O]  COG1220 ATP-dependent protease HslVU (ClpYQ), ATPase subunit
 4  7  9 14 ---------------|||-----||--||-|-|-----  28 [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
 4 11 12 13 ||||-|||-|||||------------------------  31 [O]  COG1222 ATP-dependent 26S proteasome regulatory subunit
 1  5  5  5 |||---||------------------------------   5 [R]  COG1223 Predicted ATPase (AAA+ superfamily)
 4  7  9 10 -----|||||||||------------------------  13 [K]  COG1224 DNA helicase TIP49, TBP-interacting protein
10 18 27 44 --|||---|||||-|||||---|||--|||||||||||  70 [O]  COG1225 Peroxiredoxin
10 23 32 50 ||||||||-|||--|||||---|||||||||||||||| 134 [P]  COG1226 Kef-type K+ transport systems, predicted NAD-binding component
 8 11 12 16 -|----|----|||-|--||---|||----|-------  17 [C]  COG1227 Inorganic pyrophosphatase/exopolyphosphatase
 9 16 20 28 |--||||--|-|---|--||--||||-||-|-|--||-  45 [Q]  COG1228 Imidazolonepropionase and related amidohydrolases
 1  5  5  5 |||---||------------------------------   7 [C]  COG1229 Formylmethanofuran dehydrogenase subunit A
11 17 24 37 --|--|--||-||||||-|---||||-|||-||||||-  47 [P]  COG1230 Co/Zn/Cd efflux system component
 5  8  9 11 ----------------|||---|-|--|----|--||-  12 [E]  COG1231 Monoamine oxidase
 9 15 15 22 --||-||-|--||-|---|-|-|-|---|---|--|--  22 [H]  COG1232 Protoporphyrinogen oxidase
 7 12 14 18 ||||-----||-----|||---|-|-------|--||-  53 [Q]  COG1233 Phytoene dehydrogenase and related proteins
12 24 29 44 ||||||||||||||-||||-||||||--|--||--||-  66 [R]  COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
 9 20 24 40 ||||||||----|-|-||-|||-|||-||---|--|||  55 [R]  COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
 7 16 20 23 -||||||-||||||--|||--------|--|-|--||-  37 [J]  COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing
 4  9  9 10 |||--|||-------|-------|----|---------  20 [R]  COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II
 3  8 15 25 -||----|------|------------|||||||||||  34 [S]  COG1238 Predicted membrane protein
 5 13 13 16 |||||-||--------|||---|----|----|-----  22 [H]  COG1239 Mg-chelatase subunit ChlI
 4 11 11 14 |||||--|--------||----|----|----|-----  15 [H]  COG1240 Mg-chelatase subunit ChlD
 4 12 14 16 ||||||||||||||------------------------  45 [L]  COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family
 6  8 10 18 -|-----|------||---|---|||--|-|-------  18 [R]  COG1242 Predicted Fe-S oxidoreductase
 7 15 16 18 ||||||||||-|||-|---|---|--------------  18 [KB] COG1243 Histone acetyltransferase
 2  9  9 11 ||||||||---------------|--------------  11 [R]  COG1244 Predicted Fe-S oxidoreductase
 4 12 14 16 ||||||||||||||------------------------  16 [R]  COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
 6  8 12 21 --||----------|---|---|-|--||-||||----  23 [E]  COG1246 N-acetylglutamate synthase and related acetyltransferases
 7 11 16 26 --|-----|-|-----|||---||||-||-|-|--||-  31 [M]  COG1247 Sortase and related acyltransferases
12 23 33 56 |||||-|||||||-|||||||-|-||||||||||-||| 162 [C]  COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
 7 12 18 31 ---||-|-|||-------||--|||--||-|-|--|||  93 [I]  COG1250 3-hydroxyacyl-CoA dehydrogenase
 5  8 10 19 --|-----------|-------|||--||---|--||-  24 [C]  COG1251 NAD(P)H-nitrite reductase
 8 12 16 29 ---|-----|-||---|||---|-||-||-|||---|-  55 [C]  COG1252 NADH dehydrogenase, FAD-containing subunit
12 20 28 52 --||-------||-|||||||||||||||||||||||| 103 [R]  COG1253 Hemolysins and related proteins containing CBS domains
 9 16 22 34 -||-|||-|||----||-|--|||||-||-|||---|-  42 [C]  COG1254 Acylphosphatases
 1  5  5  6 ||-|-||-------------------------------   6 [S]  COG1255 Uncharacterized protein conserved in archaea
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  26 [N]  COG1256 Flagellar hook-associated protein
 7 15 18 23 ||||||||||||||-------|--||----|-------  24 [I]  COG1257 Hydroxymethylglutaryl-CoA reductase
 3 10 12 14 |||||||||||--|------------------------  14 [J]  COG1258 Predicted pseudouridylate synthase
 7 10 12 16 --||--|-|||---||||--|-|---------------  16 [S]  COG1259 Uncharacterized conserved protein
 7 10 12 16 |-|--||-||||--||------|-------------|-  19 [I]  COG1260 Myo-inositol-1-phosphate synthase
 3  6  9 19 --------------||-----------||-|-|-|||-  20 [NO] COG1261 Flagellar basal body P-ring biosynthesis protein
 7 10 15 22 --|---------|---||--|-|-|--|-|||||-||-  39 [S]  COG1262 Uncharacterized conserved protein
 5  9 13 25 -------------------|-||||||||-|||--|-- 100 [G]  COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific
 5  9 13 26 -------------------|-||||||||-|||--|-- 107 [G]  COG1264 Phosphotransferase system IIB components
12 19 24 37 |-||-|--|-|---||||||||||||-||-|-|--||- 104 [R]  COG1266 Predicted metal-dependent membrane protease
 6 13 19 31 |||--|-||-|---|----|----||-||-|||||--|  33 [I]  COG1267 Phosphatidylglycerophosphatase A and related proteins
10 16 18 28 |-||-||--------|||||||||||----------||  34 [R]  COG1268 Uncharacterized conserved protein
 9 17 19 24 ||||||||||||||----||||---|------------  26 [C]  COG1269 Archaeal/vacuolar-type H+-ATPase subunit I
 8 19 23 30 |||||||||||-----||||--|||--||-|-|---|-  31 [H]  COG1270 Cobalamin biosynthesis protein CobD/CbiB
 7 14 20 36 --|||-|-------|-||--|-|-||-||-|||-||||  52 [C]  COG1271 Cytochrome bd-type quinol oxidase, subunit 1
 8 12 17 33 -----------|||----||-|||||-||||--|-||-  38 [R]  COG1272 Predicted membrane protein, hemolysin III homolog
 4  5  5  9 ------|---------------|-|--|--------|-  18 [S]  COG1273 Uncharacterized conserved protein
 6  7  7 13 ----||---|----------|||---------|-----  13 [C]  COG1274 Phosphoenolpyruvate carboxykinase (GTP)
 5 10 13 22 -|--|||----||---------|-||--|-||-|----  29 [P]  COG1275 Tellurite resistance protein and related permeases
 4  6  6 13 --------------|---|-----|---|---|---|-  13 [P]  COG1276 Putative copper export protein
 8 17 18 27 --|||||--||----||||--|-||-||----|---|-  64 [R]  COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
 8 11 19 37 ---|----------||--||--||||-|||||||-||| 127 [K]  COG1278 Cold shock proteins
 4  8 12 22 -------------------|--|||--||-|||-|-||  25 [R]  COG1279 Lysine efflux permease
 8 15 22 32 |-|-|-|||||----|-||---|-|--||||||-|||- 127 [E]  COG1280 Putative threonine efflux protein
 7 12 19 33 --------------||||||---|||||||||||-||-  34 [O]  COG1281 Disulfide bond chaperones of the HSP33 family
 3  6 12 24 ----------------||----|----||-||||-|||  26 [C]  COG1282 NAD/NADP transhydrogenase beta subunit
 5  8 11 21 -------------------|-||-|||||-|---|-|-  29 [P]  COG1283 Na+/phosphate symporter
 7 10 11 22 -------|-------|---|||-||||---|-----|-  50 [S]  COG1284 Uncharacterized conserved protein
 8 12 15 26 --------------|-||||-|||||-||--||---|-  33 [S]  COG1285 Uncharacterized membrane protein
 3  6 14 32 ---------------------|--||-|||||||||||  32 [R]  COG1286 Uncharacterized membrane protein, required for colicin V production
 4 11 12 14 |||||||-||-||---------------------|---  26 [R]  COG1287 Uncharacterized membrane protein, required for N-linked glycosylation
 4  5  7 13 -------------------|-|--||--|--|---|--  19 [S]  COG1288 Predicted membrane protein
 4  7 12 23 -----------------||-----|--||||||||-|-  55 [S]  COG1289 Predicted membrane protein
 9 14 21 33 ---||---||||--|-|||---|-|--|-||-||||||  45 [C]  COG1290 Cytochrome b subunit of the bc complex
 5  9 12 24 --------------||-----|-||--||-|-|-|||-  28 [N]  COG1291 Flagellar motor component
 5  7 10 21 ---|-----------------||-|--||-||-|--|-  37 [M]  COG1292 Choline-glycine betaine transporter
11 21 24 33 ||||||||||||||-|||||-|-|||--------|---  34 [K]  COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP
 7 12 18 33 --||----------|-||--|-|-||-||-|||-||||  46 [C]  COG1294 Cytochrome bd-type quinol oxidase, subunit 2
 9 15 23 44 --|-----------|-|||||-||||||||||||||||  63 [S]  COG1295 Predicted membrane protein
 6 10 15 29 --|---|-----------||--|-||-||-|||||-|-  35 [E]  COG1296 Predicted branched-chain amino acid permease (azaleucine resistance)
 4  8 11 13 ---|-|-----|----------|----|-|-|||||--  14 [S]  COG1297 Predicted membrane protein
 6 10 13 27 --------------||----||-||--||-|-|-|||-  31 [NU] COG1298 Flagellar biosynthesis pathway, component FlhA
 6  9 13 24 ------------------||-||||||||-|||-----  52 [G]  COG1299 Phosphotransferase system, fructose-specific IIC component
 6 14 15 19 |||--|||--|-----||----|||--|-------||-  23 [S]  COG1300 Uncharacterized membrane protein
11 17 22 36 --||-|----|---|-|-|||||||--||||-|-||||  69 [C]  COG1301 Na+/H+-dicarboxylate symporters
 5  6  7 13 ---------------|--|||--|||------------  29 [S]  COG1302 Uncharacterized protein conserved in bacteria
 2  9 10 12 ||||||||-||---------------------------  12 [S]  COG1303 Uncharacterized protein conserved in archaea
 9 20 28 48 |||||||||||||---|||--||-||-||-||-|-|||  71 [C]  COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
 9 17 21 29 |-|--|||||----|||||---|||--|-|-||--||-  74 [E]  COG1305 Transglutaminase-like enzymes, putative cysteine proteases
 2  2  2  3 -------------------|-|----------------   3 [S]  COG1306 Uncharacterized conserved protein
 6  8  9 19 ---------------|--||--||||||----------  43 [S]  COG1307 Uncharacterized protein conserved in bacteria
 4 12 13 15 |||||||||-||||------------------------  15 [K]  COG1308 Transcription factor homologous to NACalpha-BTF3
10 20 27 44 |-||-||--|----||||||--|||||||||||||||- 592 [K]  COG1309 Transcriptional regulator
 9 18 21 27 |-|||||||||||||-|||---|----||---|-----  56 [R]  COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily
 3 11 11 13 ||||||||---|||------------------------  13 [L]  COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
 4  6  8 17 ----|----------|-------|||--|--|----|-  20 [G]  COG1312 D-mannonate dehydratase
 5 10 11 12 |||--||||-|---||-------|--------------  13 [R]  COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins
 9 15 23 47 --------------|-||||||||||||||||||||||  47 [U]  COG1314 Preprotein translocase subunit SecG
 4  5  5  6 ---------------|-----|-||-----|-------   6 [L]  COG1315 Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain
 6  8  9 18 ---------------||||--|||||------------  46 [K]  COG1316 Transcriptional regulator
 5  9 11 21 ---------------|----||-||--||-|-|-|-|-  25 [NU] COG1317 Flagellar biosynthesis/type III secretory pathway protein
 4  7  8  9 -|---||||-|---||----------------------  10 [K]  COG1318 Predicted transcriptional regulators
 6  8 11 18 --------|||-------|--||-|--||---|---|-  38 [C]  COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs
 6 11 13 20 ||||-|---------|--|---|-|--|--|-----||  29 [P]  COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit
 9 18 22 36 |||||||||||----|--|-||||||--||------|-  55 [K]  COG1321 Mn-dependent transcriptional regulator
 3  6 13 26 --------------------|----|||||||||-|||  26 [S]  COG1322 Uncharacterized protein conserved in bacteria
 4  8  9 14 ||-----|-------|---|---||||-----------  16 [R]  COG1323 Predicted nucleotidyltransferase
 9 16 18 25 |-|-|||||-|--||||-|-|-------||--|----|  25 [P]  COG1324 Uncharacterized protein involved in tolerance to divalent cations
 2  8 10 11 ||||-||||||---------------------------  12 [J]  COG1325 Predicted exosome subunit
 1  7  7  8 ||||-|||------------------------------   9 [R]  COG1326 Uncharacterized archaeal Zn-finger protein
 8 11 18 36 ---------------|-||||-||||-|||||||-||-  36 [K]  COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains
 5 11 15 24 |||--|-|-------|---|---|||-||-|||-----  27 [F]  COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase
 5  5  7 16 ------------------|--||-|----------|||  17 [K]  COG1329 Transcriptional regulators, similar to M. xanthus CarD
 4  5  9 18 --------------------|||----|||||-|----  18 [L]  COG1330 Exonuclease V gamma subunit
 9 14 16 20 |-|||-|-|||---|-|-|-|-|||-----------|-  24 [O]  COG1331 Highly conserved protein containing a thioredoxin domain
 3  7  7  8 |||-||---------|------|---------------   8 [L]  COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 5  6  7 12 --------------|-||----|-|-------||----  12 [O]  COG1333 ResB protein required for cytochrome c biosynthesis
 4  6  7 10 --------------||-------||--|--|---|---  10 [N]  COG1334 Uncharacterized flagellar protein FlaG
11 21 29 47 --|||||||||||-|||-|--|||||-||||-|||||- 126 [Q]  COG1335 Amidases related to nicotinamidase
 5  7  7  7 |-----||-|----||--------|-------------  11 [L]  COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 5 10 11 12 |||-||-|||-----||-----|---------------  17 [L]  COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 6 10 13 27 --------------||----||-||--||-|-|-|||-  29 [NU] COG1338 Flagellar biosynthesis pathway, component FliP
 2  9 11 13 |||||||||||---------------------------  13 [KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon
 2  8 10 12 |-|||||||||---------------------------  13 [S]  COG1340 Uncharacterized archaeal coiled-coil protein
 3  7  9 10 -|---||||||||-------------------------  12 [R]  COG1341 Predicted GTPase or GTP-binding protein
 3  7  7  8 |||--||----------------|------|-------  10 [R]  COG1342 Predicted DNA-binding proteins
 7 12 14 15 |||-|-||||-----||--|--|-||------------  18 [L]  COG1343 Uncharacterized protein predicted to be involved in DNA repair
 5  9 12 24 --------------||-----|-||--||-|-|-|||-  81 [N]  COG1344 Flagellin and related hook-associated proteins
 5  8 10 19 --------------||-----|-||--||-|-|-|---  20 [N]  COG1345 Flagellar capping protein
 5  9 14 23 --|--|------------||---|||-||-||||--|-  30 [M]  COG1346 Putative effector of murein hydrolase
 2  3  6  9 --------------------|------||-||-|----   9 [C]  COG1347 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD
 5  9  9 10 |||----|--------||-|---|------------|-  18 [P]  COG1348 Nitrogenase subunit NifH (ATPase)
 7 10 15 29 --------------||--||--||||-||-||||--|- 145 [KG] COG1349 Transcriptional regulators of sugar metabolism
 4  8 10 12 |-|-|||-|||---||----------------------  15 [R]  COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)
10 14 16 26 ---|||--|||---||||--||||----------|--|  26 [F]  COG1351 Predicted alternative thymidylate synthase
 6 13 16 26 --||-||--------||----|-||--||-|-|-|||-  44 [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins
 6 12 13 14 |||-||||||----||------|-|-------------  18 [R]  COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs)
10 20 24 41 -||||||-------||||||-|||||||-|--||-||-  42 [S]  COG1354 Uncharacterized conserved protein
 6 13 15 17 |||-|||||||||-||--------------------|-  18 [R]  COG1355 Predicted dioxygenase
 1  4  4  5 ||-|-|--------------------------------   5 [S]  COG1356 Uncharacterized protein conserved in archaea
 7 11 16 27 --||------------|||--|||||-||--|---||| 105 [S]  COG1357 Uncharacterized low-complexity proteins
 7 16 19 26 ||||||||||||||-|---|---|||------------  41 [J]  COG1358 Ribosomal protein HS6-type (S12/L30/L7a)
 7 11 17 28 --||-------------|||--||||-||-||||-||-  56 [S]  COG1359 Uncharacterized conserved protein
 5  9 12 24 --------------||-----|-||--||-|-|-|||-  45 [N]  COG1360 Flagellar motor protein
 3  8  9 11 -||||||-||-----|----------------------  31 [M]  COG1361 S-layer domain
 7  8  8 11 -----------||--|---|-|||---|----------  14 [E]  COG1362 Aspartyl aminopeptidase
 8 17 20 30 ||||-||||-|----||-||---||||||-------|-  56 [G]  COG1363 Cellulase M and related proteins
 9 18 21 31 |||---||---||-|||||---||||-|----||-||-  33 [E]  COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase)
 1  4  4  5 ||---|-|------------------------------   5 [R]  COG1365 Predicted ATPase (PP-loop superfamily)
 9 12 14 20 ---------------||||||||||--|--|----||-  69 [T]  COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)
 4  4  4  4 ------|-------||--------|-------------   4 [L]  COG1367 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 3  7 11 23 ---------------|-------|||-||-||-||-|-  36 [M]  COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
 3 10 11 12 ||||-|||-||||-------------------------  12 [J]  COG1369 RNase P/RNase MRP subunit POP5
 2  9 11 13 |||||||||||---------------------------  13 [O]  COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit
 5 12 14 17 |||||||||||---||------|---------------  17 [S]  COG1371 Uncharacterized conserved protein
 8 12 12 16 -|--||-|--||--|-|||---|-|-------------  77 [L]  COG1372 Intein/homing endonuclease
 7 12 15 19 -||-||--||-----|---|--|-||-----|--|-||  53 [R]  COG1373 Predicted ATPase (AAA+ superfamily)
 4  8  8  9 -|---|||--||||------------------------   9 [J]  COG1374 Protein involved in ribosomal biogenesis, contains PUA domain
 5  9 12 23 ---------------|||----|||--||-|-||--|-  94 [S]  COG1376 Uncharacterized protein conserved in bacteria
 6 10 13 27 --------------||----||-||--||-|-|-|||-  32 [NU] COG1377 Flagellar biosynthesis pathway, component FlhB
 4 11 13 15 |||||||||||-------|-----|-------------  36 [K]  COG1378 Predicted transcriptional regulators
 2  6  6  8 |||--|-|----------------|-------------   9 [S]  COG1379 Uncharacterized conserved protein
 5  9 14 23 --|--|------------||---|||-||-||||--|-  30 [R]  COG1380 Putative effector of murein hydrolase LrgA
 8 13 21 41 ----------------||||||||||||||||||-|||  41 [L]  COG1381 Recombinational DNA repair protein (RecF pathway)
 3 11 13 15 |||||||||||||-------------------------  17 [O]  COG1382 Prefoldin, chaperonin cofactor
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG1383 Ribosomal protein S17E
 4 11 13 18 ||||||||--|----------|-------------|||  18 [J]  COG1384 Lysyl-tRNA synthetase (class I)
 9 15 23 46 --------------||||||-|||||||||||||||||  49 [S]  COG1385 Uncharacterized protein conserved in bacteria
 9 17 21 38 --|-|||--------|||||-|||||||-|--||-||-  43 [K]  COG1386 Predicted transcriptional regulator containing the HTH domain
 9 18 20 30 |||-||||---||-||--||--||||--|-|-----|-  40 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family
 7  8 12 19 --------------|---|-||||||-||-||------  43 [M]  COG1388 FOG: LysM repeat
 2  8 10 11 ||||-||||||---------------------------  11 [L]  COG1389 DNA topoisomerase VI, subunit B
 8 16 17 21 |||||||||-||||----||||----------------  21 [C]  COG1390 Archaeal/vacuolar-type H+-ATPase subunit E
 3  5 10 22 --------------|-------|----||-||||-||-  22 [OT] COG1391 Glutamine synthetase adenylyltransferase
 7 14 16 23 |||--||--|-----|--|-|--||--|--|||---|-  28 [P]  COG1392 Phosphate transport regulator (distant homolog of PhoU)
 6 11 18 35 ----------------|-||--|||||||||||||||-  75 [P]  COG1393 Arsenate reductase and related proteins, glutaredoxin family
 9 17 19 24 ||||||||||||||----||||---|------------  25 [C]  COG1394 Archaeal/vacuolar-type H+-ATPase subunit D
 2  9 11 13 |||||||||||---------------------------  13 [K]  COG1395 Predicted transcriptional regulator
11 15 23 40 |-|-----|-----|||-||-|||||-|||||||-||| 387 [K]  COG1396 Predicted transcriptional regulators
 6 10 10 13 -||---|-------|-|-|----|-|--|-------|-  15 [O]  COG1397 ADP-ribosylglycohydrolase
 3  7  7  8 -----------||---||---------|----|----|  10 [I]  COG1398 Fatty-acid desaturase
 7 10 16 30 --------------|||||---||||-|||||||----  30 [R]  COG1399 Predicted metal-binding, possibly nucleic acid-binding protein
 4 12 14 16 ||||||||||||||------------------------  16 [U]  COG1400 Signal recognition particle 19 kDa protein
 7 10 12 15 |-|--|--||----|--||-----||--|-----|---  16 [V]  COG1401 GTPase subunit of restriction endonuclease
 7 11 14 19 ||-|---||||----|||----|-|----------||-  24 [R]  COG1402 Uncharacterized protein, putative amidase
 6 10 14 24 ---|------------|||---||||--|||-|--||-  58 [V]  COG1403 Restriction endonuclease
11 20 26 35 --||--|-|-|||||-||||--|||||||||-|||-|- 105 [O]  COG1404 Subtilisin-like serine proteases
 4 12 14 16 ||||||||||||||------------------------  39 [K]  COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
 4  5  5  6 ---------------|-----|-||-----|-------   6 [N]  COG1406 Predicted inhibitor of MCP methylation, homolog of CheC
 3 10 13 18 |||||||||||------------------------||-  22 [R]  COG1407 Predicted ICC-like phosphoesterases
 9 14 15 24 |-|-----|-----|-|-|-|-||||--|---|-|-|-  30 [R]  COG1408 Predicted phosphohydrolases
 9 18 24 39 |-|--||||-|||-|-||--|-||||-||-|||--||-  75 [R]  COG1409 Predicted phosphohydrolases
 6 10 15 25 ---------------||||---|||--||||||--||-  28 [E]  COG1410 Methionine synthase I, cobalamin-binding domain
 1  5  5  5 |||---||------------------------------   5 [R]  COG1411 Uncharacterized protein related to proFAR isomerase (HisA)
 4 12 14 16 ||||||||||||||------------------------  19 [R]  COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
 8 13 14 19 |-||-------|||--||--||--|--||-------|-  54 [C]  COG1413 FOG: HEAT repeat
 7 10 14 25 ---|----------||--|---|-|--||-|||-|||-  99 [K]  COG1414 Transcriptional regulator
 3  7  9 12 |---|||||||-------------------------|-  13 [S]  COG1415 Uncharacterized conserved protein
 4  8  8  9 |--||-|-------|---|-------------|---|-  10 [S]  COG1416 Uncharacterized conserved protein
 1  4  4  4 ||----||------------------------------   9 [S]  COG1417 Uncharacterized conserved protein
 8 19 20 36 ||||||||------||--||-|-||||-|-----|-|-  51 [R]  COG1418 Predicted HD superfamily hydrolase
 5  8  9 14 --------------||-----|-||--|--|-|-|---  14 [N]  COG1419 Flagellar GTP-binding protein
 7 13 15 32 ---------------|||-||-|||||--|--|-|||-  32 [K]  COG1420 Transcriptional regulator of heat shock gene
 2  6  6  6 ||--||-|-------|----------------------   6 [L]  COG1421 Uncharacterized protein predicted to be involved in DNA repair
 1  8  8 10 ||||||||------------------------------  11 [S]  COG1422 Predicted membrane protein
 3  8  8  9 |||--|||--|---|-----------------------   9 [L]  COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III
 3  3  3  4 -|------------|---------|-------------   4 [H]  COG1424 Pimeloyl-CoA synthetase
 6  8 13 26 ---------------||---||--||-||||||----|  27 [S]  COG1426 Uncharacterized protein conserved in bacteria
 7  8  9 13 ----|-|-|-|---|---|-|---|---------|---  13 [R]  COG1427 Predicted periplasmic solute-binding protein
 4  5  6 12 ------------------|--|--|||-----|-----  16 [F]  COG1428 Deoxynucleoside kinases
 4 11 11 15 ||||---|--------||----|----|----|---|-  48 [H]  COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases
 6 13 14 19 ||-|-|-||------|||---|-------|--|--||-  21 [S]  COG1430 Uncharacterized conserved protein
 2  4  4  4 -|----||------|-----------------------   4 [J]  COG1431 Uncharacterized protein containing piwi/argonaute domain
 7 17 19 25 ||||-|||------|-|||--||----|--|--||||-  41 [S]  COG1432 Uncharacterized conserved protein
 5 11 11 13 |||-|||||------|-------|------|-------  28 [S]  COG1433 Uncharacterized conserved protein
 7 11 19 30 --------------|||||---||||-|||||||-|||  58 [S]  COG1434 Uncharacterized conserved protein
 8 12 15 30 ---||---|----|-|--|--|-||||-|-||----|-  30 [F]  COG1435 Thymidine kinase
 8 16 18 20 ||||||||||||||----||-|---|------------  20 [C]  COG1436 Archaeal/vacuolar-type H+-ATPase subunit F
 5 12 14 15 ||||-||||||----------|-|----|---|-----  17 [F]  COG1437 Adenylate cyclase, class 2 (thermophilic)
 6  7 10 23 ---------------|--|-|-||||--|-||------  30 [K]  COG1438 Arginine repressor
 4 12 14 16 ||||||||||||||------------------------  16 [R]  COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
 3  4  6 14 ---------------------|-|||--|-|-------  28 [G]  COG1440 Phosphotransferase system cellobiose-specific component IIB
 1  1  3  8 ----------------------------|-||------   8 [H]  COG1441 O-succinylbenzoate synthase
 2  4  7 13 ------------------------||--|--|--|-||  30 [M]  COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases
 5  6  6 11 ---|-------|||--------|-----|---------  11 [I]  COG1443 Isopentenyldiphosphate isomerase
 5  9 13 19 ---|-|||||||||--------------|-||------  23 [R]  COG1444 Predicted P-loop ATPase fused to an acetyltransferase
 6  9 13 25 ------------------||-||||||||-|||-----  55 [G]  COG1445 Phosphotransferase system fructose-specific component IIB
 5 10 13 18 ---|||--||--|---||----------|-|-|--||-  21 [E]  COG1446 Asparaginase
 3  4  6 15 ---------------------|-|||--|-|-------  31 [G]  COG1447 Phosphotransferase system cellobiose-specific component IIA
 4  7 12 20 -----------||------||------|||||||--|-  31 [E]  COG1448 Aspartate/tyrosine/aromatic aminotransferase
 5  9 10 12 -||-||--||----|-||---|----------------  19 [G]  COG1449 Alpha-amylase/alpha-mannosidase
 4  7 11 16 --------------|----||------||||-|-|||-  30 [NU] COG1450 Type II secretory pathway, component PulD
 7 16 22 34 ||||-||-------|---||--||--|||||-||||||  43 [R]  COG1451 Predicted metal-dependent hydrolase
 3  6 13 26 --------------|------|-----|||||||||||  27 [M]  COG1452 Organic solvent tolerance protein OstA
 4  6  6  6 |-|------------|||-----|--------------  16 [R]  COG1453 Predicted oxidoreductases of the aldo/keto reductase family
 9 18 23 36 |-|||||--||||-||---|--||||-||-|||---|-  73 [C]  COG1454 Alcohol dehydrogenase, class IV
 3  4  6 15 ---------------------|-|||--|-|-------  37 [G]  COG1455 Phosphotransferase system cellobiose-specific component IIC
 1  5  5  5 |||---||------------------------------   6 [C]  COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)
 5  7  9 17 ----||---|-|------------|--||--|-|----  24 [F]  COG1457 Purine-cytosine permease and related proteins
 3  8  8  9 |||--|||--|---|-----------------------   9 [R]  COG1458 Predicted DNA-binding protein containing PIN domain
 8 12 19 31 --------------|||||||--|||-|||||||-||-  45 [NU] COG1459 Type II secretory pathway, component PulF
 2  9 11 13 |||||||||||---------------------------  13 [S]  COG1460 DNA-directed RNA polymerase, subunit F
 5  7  8 18 ---------------|--||--|||||-----------  22 [R]  COG1461 Predicted kinase related to dihydroxyacetone kinase
 4  7  9 14 --------------|-|||--------||---||-|--  16 [M]  COG1462 Uncharacterized protein involved in formation of curli polymers
 4  8 15 29 --------------|-||----|----|||||||||||  87 [Q]  COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component
 7 11 18 34 ------------------||||||||-||||||||||-  53 [P]  COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen
 2  7  7  7 ||||--||------|-----------------------   7 [E]  COG1465 Predicted alternative 3-dehydroquinate synthase
 9 15 23 49 --------------|||||-||||||||||||||||||  50 [L]  COG1466 DNA polymerase III, delta subunit
 4 12 14 16 ||||||||||||||------------------------  17 [L]  COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit
 7 11 14 15 |||--||-|||---|||--|----||------------  23 [L]  COG1468 RecB family exonuclease
 5 13 15 20 ||||||||--|----|--------|--|-|--||----  20 [S]  COG1469 Uncharacterized conserved protein
 2  4  4  5 --|--||-----------------|-------------   6 [S]  COG1470 Predicted membrane protein
 4 12 14 16 ||||||||||||||------------------------  19 [J]  COG1471 Ribosomal protein S4E
 9 13 21 36 ---------|--|--||||--|||||-|||||||-|||  62 [G]  COG1472 Beta-glucosidase-related glycosidases
 9 17 21 35 --||||---|-----|||||--||||-||--||-|||-  89 [R]  COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase
 4 10 12 14 |-|||||-||||||------------------------  41 [LO] COG1474 Cdc6-related protein, AAA superfamily ATPase
10 18 27 49 ||-|-||-|||---|-|-|-||||||-||||-|||||| 111 [K]  COG1475 Predicted transcriptional regulators
 5 12 13 18 ||||-||---------|-|----|||-|-------|--  34 [K]  COG1476 Predicted transcriptional regulators
 9 12 19 30 --|-----------||--||||-|||-|||||||-||-  35 [H]  COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis
 4  9  9 12 ||||--||------------|-|--|------------  13 [S]  COG1478 Uncharacterized conserved protein
 7 14 16 21 -|||-|---------||--|--|||-|-|-||-||---  58 [S]  COG1479 Uncharacterized conserved protein
 6  8  8 10 ---------------|||-|||-||-------------  10 [R]  COG1480 Predicted membrane-associated HD superfamily hydrolase
 4  6  7 18 ---------------|---|--|||||-----------  18 [S]  COG1481 Uncharacterized protein conserved in bacteria
 8 11 14 26 ------|----||--|--|--||||||-|-||------  30 [G]  COG1482 Phosphomannose isomerase
 4  6  6  7 -----|||--|----|--------------------|-   9 [R]  COG1483 Predicted ATPase (AAA+ superfamily)
 5  9 10 23 --|-----------|-------|||||-|---|---|- 125 [L]  COG1484 DNA replication protein
 4  7 13 23 -----------||-----|---|----||||-||-|||  25 [R]  COG1485 Predicted ATPase
 3  5  6 14 ---------------|-------||---|-|-----|-  37 [G]  COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases
 6 12 17 21 -||--||-||------|||---|-----||-||--|||  84 [R]  COG1487 Predicted nucleic acid-binding protein, contains PIN domain
12 24 32 54 --|||||||||||-||||||-||||||||||||||-|-  60 [H]  COG1488 Nicotinic acid phosphoribosyltransferase
 7 12 18 26 |---|-|-|||---||||-----||--||-||---||-  26 [R]  COG1489 DNA-binding protein, stimulates sugar fermentation
 8 11 16 29 -----------||-||--||--||||-||-||||----  29 [J]  COG1490 D-Tyr-tRNAtyr deacylase
 2  9 11 13 |||||||||||---------------------------  13 [J]  COG1491 Predicted RNA-binding protein
 8 18 21 27 |||||-||-|------||||--|||--||-|-|--||-  31 [H]  COG1492 Cobyric acid synthase
 5  9 12 24 -------|-----------|-|-||||--|--||-||-  24 [T]  COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism
 7 10 13 22 --|-------------||||--|||---|-||---||-  26 [G]  COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins
 4  7 14 28 ------------------|-|---|--|||||||||||  35 [O]  COG1495 Disulfide bond formation protein DsbB
 9 14 21 37 --------------|-|||||||||--|||||||||||  39 [S]  COG1496 Uncharacterized conserved protein
 1  7  7  8 |||||-||------------------------------   8 [K]  COG1497 Predicted transcriptional regulator
 4 12 14 16 ||||||||||||||------------------------  21 [J]  COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog
 4 12 14 16 ||||||||||||||------------------------  17 [J]  COG1499 NMD protein affecting ribosome stability and mRNA decay
 4 12 14 16 ||||||||||||||------------------------  16 [J]  COG1500 Predicted exosome subunit
 7 11 14 21 ----|---||-||--||------|||--|---|--||-  37 [G]  COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases
11 19 27 47 ----|-|-|--|||-|||-||-|||||||||||||||| 104 [I]  COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes
 5 13 15 17 |||||||||||||||-----------------------  20 [J]  COG1503 Peptide chain release factor 1 (eRF1)
 1  5  5  6 |-|--|||------------------------------   7 [S]  COG1504 Uncharacterized conserved protein
 5  6  8 13 -----|----------|-|---|----------|-|||  17 [E]  COG1505 Serine proteases of the peptidase family S9A
 8 12 17 21 ---|||--|||||----|||----|--|-|-----|||  48 [E]  COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases
 3  3  3  6 --------------||------|---------------   6 [S]  COG1507 Uncharacterized conserved protein
 5  9 14 28 --------------|-----||-||--||||-|||||-  30 [K]  COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
 8 10 14 22 -||-----------||--||-|--|---||||---||-  25 [E]  COG1509 Lysine 2,3-aminomutase
 3  5  5  8 -|---|------------------|-------|---|-  11 [K]  COG1510 Predicted transcriptional regulators
 4  5  6 14 |-----------------|---||||------------  27 [S]  COG1511 Predicted membrane protein
 5  8 12 16 ---------------|||---|--||-||--||--||-  23 [R]  COG1512 Beta-propeller domains of methanol dehydrogenase type
 3  5  6  8 --------------|-||---------||---|-----   8 [P]  COG1513 Cyanate lyase
 9 18 22 33 |||-|||||||---|||-|---|||--||---|--||-  38 [J]  COG1514 2'-5' RNA ligase
 9 14 17 23 ---||||||||-|-|||-|----||---||--------  23 [L]  COG1515 Deoxyinosine 3'endonuclease (endonuclease V)
 5  8 10 19 --------------||-----|-||--||-|-|-|---  21 [NUO] COG1516 Flagellin-specific chaperone FliS
 3  5  6  6 -|--||--||----|-----------------------  12 [L]  COG1517 Uncharacterized protein predicted to be involved in DNA repair
 9 17 21 28 |||-|||||||---|||--|--|-||--|--|-||---  36 [L]  COG1518 Uncharacterized protein predicted to be involved in DNA repair
 4  7 14 27 --------------|----||------|||||||||||  27 [M]  COG1519 3-deoxy-D-manno-octulosonic-acid transferase
 7 14 18 26 ||||-||--------|--|--||-|--||||-|--|-|  66 [S]  COG1520 FOG: WD40-like repeat
 9 15 17 25 --------------||||||-||||-||-|--||||--  25 [K]  COG1521 Putative transcriptional regulator, homolog of Bvg accessory factor
 6 16 23 37 |||||||||||-------|---|||--||-||||-||- 250 [K]  COG1522 Transcriptional regulators
10 14 18 30 --|------|-----|-||||-|||||||-|||---|-  36 [G]  COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
 9 15 17 21 ----|||--|-|||-||-----|||--|-|----|||-  34 [R]  COG1524 Uncharacterized proteins of the AP superfamily
 7 16 17 26 ||-|-|-|---||-|-|-----|-|-||---|-||-|-  50 [L]  COG1525 Micrococcal nuclease (thermonuclease) homologs
 5 12 17 31 |||-|-|-||------------|-|--||-|||-|||-  32 [C]  COG1526 Uncharacterized protein required for formate dehydrogenase activity
 7 15 15 18 |||||||||--|||----||-----|------------  18 [C]  COG1527 Archaeal/vacuolar-type H+-ATPase subunit C
 6 11 13 23 |-|---|------|-|------|||-|-|-||--|---  29 [P]  COG1528 Ferritin-like protein
 7  9 13 19 --------|||---|---|--||-|--||---|--||-  60 [C]  COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs
10 16 25 42 ---|-|-||||---||||-||-|||--|||||||-|||  56 [J]  COG1530 Ribonucleases G and E
 2  6  8  8 ||---||||||---------------------------   8 [S]  COG1531 Uncharacterized protein conserved in archaea
 1  4  4  4 ||----||------------------------------   4 [R]  COG1532 Predicted RNA-binding protein
 8 16 20 26 -||-|||||||----|-|-|--|||--|----|--|||  36 [L]  COG1533 DNA repair photolyase
 5 13 20 32 ||||-|||-||--------|---|||-|||||||----  32 [J]  COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
 3  4  6  9 ---------------|--------|--||-|-----|-  10 [Q]  COG1535 Isochorismate hydrolase
 6 10 13 27 --------------||----||-||--||-|-|-|||-  30 [N]  COG1536 Flagellar motor switch protein
 4 12 14 16 ||||||||||||||------------------------  18 [R]  COG1537 Predicted RNA-binding proteins
 4  8 15 27 --------------|-||-|-------||||||||||| 113 [MU] COG1538 Outer membrane protein
 8 14 21 41 -----------||---|||||-||||-||||||||||-  47 [H]  COG1539 Dihydroneopterin aldolase
 6  9 13 22 -----|------------||--|-|--||-|||||-|-  26 [R]  COG1540 Uncharacterized proteins, homologs of lactam utilization protein B
 7 10 12 13 |-|---|--|------|-||----|---|||-|-----  23 [H]  COG1541 Coenzyme F390 synthetase
 3  4  4  4 -|-----|------||----------------------   4 [S]  COG1542 Uncharacterized conserved protein
 5  7  7 10 -----|----------||---||||-------------  11 [S]  COG1543 Uncharacterized conserved protein
10 14 21 38 --------------||||||||||||-||||||--|||  43 [J]  COG1544 Ribosome-associated protein Y (PSrp-1)
 4 11 13 16 |||||||||||-----------|------------|--  48 [R]  COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon
 9 15 21 40 ---|----------||||||--|||||||||-|||||-  46 [R]  COG1546 Uncharacterized protein (competence- and mitomycin-induced)
 6  8 10 13 ---||---|||---|-|||-----|-------------  13 [S]  COG1547 Uncharacterized conserved protein
 1  5  5  5 |||---||------------------------------   5 [KG] COG1548 Predicted transcriptional regulator/sugar kinase
 2  9  9 11 ||||||||-|----------------------------  12 [J]  COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain
 4  5  5  9 ---------------|--|---|||-------------   9 [S]  COG1550 Uncharacterized protein conserved in bacteria
 4  6 10 20 ---------------|-----|-||--|||||--|---  20 [T]  COG1551 Carbon storage regulator (could also regulate swarming and quorum sensing)
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG1552 Ribosomal protein L40E
 3  6  9 15 |||----|-------|-----------||-||------  21 [P]  COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction
 6  9 10 16 -----|-----|----|-----|||||-|----|----  22 [G]  COG1554 Trehalose and maltose hydrolases (possible phosphorylases)
 8 12 18 31 --|------------|||||--||||-||||||||---  40 [L]  COG1555 DNA uptake protein and related DNA-binding proteins
 5  8 11 17 ---|--|-----------||----||--|--||||---  17 [S]  COG1556 Uncharacterized conserved protein
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  26 [N]  COG1558 Flagellar basal body rod protein
 7 11 19 39 --------------|---||-|||||-|||||||||||  39 [R]  COG1559 Predicted periplasmic solute-binding protein
 4  7 14 30 -------------------||-|----|||||||||||  48 [M]  COG1560 Lauroyl/myristoyl acyltransferase
 6  9 15 26 --------------||---|-|-||--|||||||-||-  27 [S]  COG1561 Uncharacterized stress-induced protein
 8 13 15 22 |--|-----|-||---|||---|-|----|--||-||-  30 [I]  COG1562 Phytoene/squalene synthetase
 4  7  7  8 ||---|---------|||-------------------|   9 [P]  COG1563 Predicted subunit of the Multisubunit Na+/H+ antiporter
 7 10 11 19 -----------||--|--||-|-|||--------|-|-  19 [H]  COG1564 Thiamine pyrophosphokinase
 3  7 10 17 --------------|-||-----------|--||||||  17 [S]  COG1565 Uncharacterized conserved protein
 3  5 11 21 --------------|---------|--||-||||-|||  66 [V]  COG1566 Multidrug resistance efflux pump
 3  7  7  8 |||-||---------|------|---------------   8 [L]  COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 2  4  4  5 -|---||-------|-----------------------   6 [R]  COG1568 Predicted methyltransferases
 3  6  6  7 -|---||---------||-----------|--------  10 [R]  COG1569 Predicted nucleic acid-binding protein, contains PIN domain
 8 12 20 41 ---------------||-|||-||||-|||||||||||  42 [L]  COG1570 Exonuclease VII, large subunit
 2  9 11 13 |||||||||||---------------------------  17 [R]  COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
 2  5  5  6 |-|--||---------|---------------------   9 [S]  COG1572 Uncharacterized conserved protein
11 20 26 39 --|||||-|||---||||||-|||-|----||||||||  59 [L]  COG1573 Uracil-DNA glycosylase
 9 14 16 24 --||||----|---||--||--|-|--||---|--||-  33 [R]  COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold
 7  8 11 21 ---|-----------|||-|--|-||--|-||------  24 [H]  COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase
 5 10 17 34 ---------------|--||---||||||||||||||-  34 [S]  COG1576 Uncharacterized conserved protein
 6 13 16 20 ||||-|||||||||-------|--||------------  25 [I]  COG1577 Mevalonate kinase
 4  9  9 10 |||--||||-----||----------------------  10 [S]  COG1578 Uncharacterized conserved protein
 7  7  7 13 --------------|---|-||||----------|---  13 [R]  COG1579 Zn-ribbon protein, possibly nucleic acid-binding
 5  8 10 18 --------------||-----|-||--||-|-|-|---  21 [N]  COG1580 Flagellar basal body-associated protein
 2  7  9 11 ||--|||||||---------------------------  15 [K]  COG1581 Archaeal DNA-binding protein
 3  4  4  6 ---------------|-----|-||-------------   6 [N]  COG1582 Uncharacterized protein, possibly involved in motility
 3  8  8  9 |||-|||-------||----------------------  14 [L]  COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 4  7  9 14 |-|-|----|-||---------------|-||------  18 [S]  COG1584 Predicted membrane protein
 9 15 22 33 ||-|-|-||||----|||||--||---|||||---||-  35 [OU] COG1585 Membrane protein implicated in regulation of membrane protease activity
 6 11 15 23 -|--|||-|||---||-------||--|||--|-----  28 [E]  COG1586 S-adenosylmethionine decarboxylase
11 23 29 47 |||||-||||-||-|-|||||-|||--||||||||-|-  57 [H]  COG1587 Uroporphyrinogen-III synthase
 2  9  9 11 ||||||||--|---------------------------  12 [J]  COG1588 RNase P/RNase MRP subunit p29
 6 10 18 37 ----------------|||--|||||-|||||||-|||  37 [M]  COG1589 Cell division septal protein
 3  7  9 10 -|---||||||||-------------------------  12 [S]  COG1590 Uncharacterized conserved protein
 2  7  9 10 ||-|-||||||---------------------------  11 [L]  COG1591 Holliday junction resolvase - archaeal type
 7 13 13 13 |||--|||-|-----||--|---||---------|---  28 [C]  COG1592 Rubrerythrin
 6  7 11 15 ---------------|---|-||-|--||-||---||-  48 [G]  COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
 4 11 13 15 |||||||-||||||------------------------  29 [K]  COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS
 8 12 19 34 ---------------|||||-|||||-|||||||-||- 172 [K]  COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
 4  8 14 21 --------------||||---------||||||||||-  41 [M]  COG1596 Periplasmic protein involved in polysaccharide export
 8 12 15 28 ----|------||--||||---||||-||------||-  46 [IR] COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
 5 13 15 19 |-|||-|--------|||-------|--|----|||||  43 [S]  COG1598 Uncharacterized conserved protein
 4 12 13 15 ||||||||-|||||------------------------  26 [L]  COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
 5 11 15 25 |-|---|---------|||----|||-||-|-|--||-  31 [C]  COG1600 Uncharacterized Fe-S protein
 4 12 14 16 ||||||||||||||------------------------  19 [J]  COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain
 2  8 10 12 |-|||||||||---------------------------  17 [S]  COG1602 Uncharacterized conserved protein
 3 10 11 12 ||||-|||-||||-------------------------  12 [J]  COG1603 RNase P/RNase MRP subunit p30
 5  6  6  6 ------||-|----||--------|-------------   7 [L]  COG1604 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
10 21 30 51 |||||-|||||||-||--||--||||-||||||||||-  68 [E]  COG1605 Chorismate mutase
 4  9  9  9 |||---||-------|||-----|--------------  11 [R]  COG1606 ATP-utilizing enzymes of the PP-loop superfamily
 7 11 18 35 ---||---|||-------|-|-|-|--||-|||||||-  49 [I]  COG1607 Acyl-CoA hydrolase
 2  9 11 13 |||||||||||---------------------------  13 [R]  COG1608 Predicted archaeal kinase
 6 10 16 31 ---------------|--||--|||||||||||--||- 277 [K]  COG1609 Transcriptional regulators
 5  9 12 20 -----------|---|------|||--|-||-|||-|-  20 [S]  COG1610 Uncharacterized conserved protein
12 19 27 43 --|-||||||-|--|||-|||-|-||-||||||||||-  56 [R]  COG1611 Predicted Rossmann fold nucleotide-binding protein
 9 13 16 26 ---|------|||-|-|||---|-|--|-|--|--|||  27 [O]  COG1612 Uncharacterized protein required for cytochrome oxidase assembly
 4  7 11 21 ----------------||----|-|--|||--||-||-  23 [P]  COG1613 ABC-type sulfate transport system, periplasmic component
 1  5  5  5 |||---||------------------------------   7 [C]  COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit
 4  5  5  8 ------|---------||----||--------------  11 [S]  COG1615 Uncharacterized conserved protein
 1  6  6  7 |||--|||------------------------------   7 [S]  COG1617 Uncharacterized conserved protein
 4 10 12 14 |||-|||||||---||----------------------  14 [F]  COG1618 Predicted nucleotide kinase
 7 12 16 25 ----|-----------||||-|-||||||-|-||---|  31 [V]  COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF
 6 11 15 24 ---|--||-|--------|--|--|--||-|||||-|-  34 [C]  COG1620 L-lactate permease
 5  9 12 16 -----------||--|------||||--|-|||---|-  23 [G]  COG1621 Beta-fructosidases (levanase/invertase)
 9 13 19 34 ---|--|-||||--|-|||---|-|--|||--|--|||  60 [C]  COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2
 4  5  5  8 ---------------|---|--|||-------------   8 [R]  COG1623 Predicted nucleic-acid-binding protein (contains the HHH domain)
 7 15 16 26 -|||-|||------|-|||-||-||||-----------  27 [S]  COG1624 Uncharacterized conserved protein
 4  9  9 10 |||--|-|--------|||----|--------------  12 [C]  COG1625 Fe-S oxidoreductase, related to NifB/MoaA family
 5  7  8 12 -----------|||--|----|-----||---|-----  17 [G]  COG1626 Neutral trehalase
 1  4  4  5 ||---|-|------------------------------   5 [S]  COG1627 Uncharacterized protein conserved in archaea
 3 10 12 14 |||||||||||-------|-------------------  14 [S]  COG1628 Uncharacterized conserved protein
 4  8 14 25 --------------|-||-|-------||||||||||- 242 [P]  COG1629 Outer membrane receptor proteins, mostly Fe transport
 2  6  7  9 ||--|||--||---------------------------  10 [S]  COG1630 Uncharacterized protein conserved in archaea
 4 12 14 16 ||||||||||||||------------------------  17 [J]  COG1631 Ribosomal protein L44E
 4 12 14 16 ||||||||||||||------------------------  19 [J]  COG1632 Ribosomal protein L15E
 6  9  9 14 |-|--|---|----||-------||-----------|-  25 [S]  COG1633 Uncharacterized conserved protein
 2  9 11 13 |||||||||||---------------------------  13 [R]  COG1634 Uncharacterized Rossmann fold enzyme
 4 11 13 14 ||||-||||||||--|----------------------  14 [H]  COG1635 Flavoprotein involved in thiazole biosynthesis
 5  9 11 17 --------------||---|---|||---|-|-||--|  17 [S]  COG1636 Uncharacterized protein conserved in bacteria
 4  8 10 14 ||-|-|-||||-----|-----|---------------  15 [L]  COG1637 Predicted nuclease of the RecB family
 7  9 13 19 ---------------|-|-|-||-|--||-|||--||-  53 [G]  COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
 3  4  5  5 ---------------|-----|-----|--|---|---  10 [T]  COG1639 Predicted signal transduction protein
10 12 15 25 --------|-----|-|||||||--|-||-|||-----  26 [G]  COG1640 4-alpha-glucanotransferase
 5 10 10 10 |||---||-------|||----||--------------  12 [S]  COG1641 Uncharacterized conserved protein
 6  9 15 25 -----------|||----|--||----|||||||-||-  54 [L]  COG1643 HrpA-like helicases
 4 12 14 16 ||||||||||||||------------------------  16 [K]  COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
 2  7  9 10 -|||-||||||---------------------------  10 [R]  COG1645 Uncharacterized Zn-finger containing protein
 3 10 12 17 |||||||||||-------------|-------------  18 [R]  COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold
 3  3  3  6 ---------------|-----|--|-------------   9 [R]  COG1647 Esterase/lipase
 8 18 23 37 |||||-|||-|||-|----|--|||--||||--|-||-  43 [H]  COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)
 4  7  7 10 ----------------|||-----|---|---|---|-  18 [S]  COG1649 Uncharacterized protein conserved in bacteria
 2  8 10 12 -||||||||||---------------------------  12 [S]  COG1650 Uncharacterized protein conserved in archaea
 9 14 21 39 ---|--|-|-----|-|||-|-|-|--|||||||||||  65 [O]  COG1651 Protein-disulfide isomerase
 5  7 13 22 ----------------|-|--|--|--|||||||-||-  31 [S]  COG1652 Uncharacterized protein containing LysM domain
 9 15 22 38 ---|||--|||----||||--|||||-||||||---|- 209 [G]  COG1653 ABC-type sugar transport system, periplasmic component
 4  8 13 23 --||-||-----------|----|||-|||||------  23 [K]  COG1654 Biotin operon repressor
 3  3  3  4 ---------------|-----|-|--------------   4 [S]  COG1655 Uncharacterized protein conserved in bacteria
 7 10 12 15 ----|||||||---||-----||---------|-----  16 [S]  COG1656 Uncharacterized conserved protein
 4  7  7  7 --|----|---||---||------|-------------  10 [I]  COG1657 Squalene cyclase
 5 12 13 22 |||-|||-------|----|-|-||||-----------  24 [L]  COG1658 Small primase-like proteins (Toprim domain)
 3  3  3  4 --------------||------|---------------   4 [S]  COG1659 Uncharacterized protein, linocin/CFP29 homolog
 5  7 13 27 ------------------||--||||-|||||||----  27 [R]  COG1660 Predicted P-loop-containing kinase
 4 11 12 18 |-||||||--|-------------|---|-|-----|-  18 [R]  COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif
 5  5  6  9 --|------|----|--|----------|--|------  46 [L]  COG1662 Transposase and inactivated derivatives, IS1 family
 4  7 14 27 --------------|----||------|||||||||||  27 [M]  COG1663 Tetraacyldisaccharide-1-P 4'-kinase
 4  8 11 15 --------------------||-||--||||-|-||--  21 [M]  COG1664 Integral membrane protein CcmA involved in cell shape determination
 2  6  6  6 |||---||-|----------------------------   6 [S]  COG1665 Uncharacterized protein conserved in archaea
 4  6  9 16 ----------------|-----|-|--||-|||-|---  16 [S]  COG1666 Uncharacterized protein conserved in bacteria
 1  4  4  4 ||----||------------------------------   5 [S]  COG1667 Uncharacterized protein conserved in archaea
 6 13 16 21 ||||-||-|||----|--|----|||---|-----|--  26 [CP] COG1668 ABC-type Na+ efflux pump, permease component
 5  8  9  9 -||---|--------|-||--------------|-||-  24 [R]  COG1669 Predicted nucleotidyltransferases
 9 19 26 46 -|||||-----||--||-||--|||||||-|||||||| 183 [J]  COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
 3  5  8 19 ---------------------|-||--||-|----||-  19 [S]  COG1671 Uncharacterized protein conserved in bacteria
 6 11 12 13 |||--|--||-----|||-|--------|-----|---  91 [R]  COG1672 Predicted ATPase (AAA+ superfamily)
 2  5  6  7 ||---||-||----------------------------  11 [S]  COG1673 Uncharacterized protein conserved in archaea
 7 12 20 42 ----------------|-|-||||||||||||||||||  84 [D]  COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
 4 11 13 14 ||||-|||||||||------------------------  15 [K]  COG1675 Transcription initiation factor IIE, alpha subunit
 4 12 14 16 ||||||||||||||------------------------  21 [J]  COG1676 tRNA splicing endonuclease
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  26 [NU] COG1677 Flagellar hook-basal body protein
 4  6 13 27 ------------------|-|-|----|||||||-|||  27 [K]  COG1678 Putative transcriptional regulator
 3  9 10 13 |||--||||-|----------------|--------|-  13 [S]  COG1679 Uncharacterized conserved protein
 7 12 18 35 --|--|--|-|-----|||---||||-|||--|--||| 111 [V]  COG1680 Beta-lactamase class C and other penicillin binding proteins
 2  7  8 10 -||||||--||---------------------------  29 [N]  COG1681 Archaeal flagellins
 6 12 19 30 --|---|-------|-||----||||-|||||-|||||  37 [GM] COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component
 6 10 12 16 |-|-----------||---|---||--||-|-|---|-  17 [S]  COG1683 Uncharacterized conserved protein
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  26 [NU] COG1684 Flagellar biosynthesis pathway, component FliR
 2  9 11 12 |||||||||||---------------------------  12 [EH] COG1685 Archaeal shikimate kinase
 6  9 17 37 -------------------|||||||-|||||||-|||  83 [M]  COG1686 D-alanyl-D-alanine carboxypeptidase
 5  6  6  8 --|----------------|--|-|------|--|---   9 [E]  COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance)
 4  8 10 11 |||--||-|||---||----------------------  15 [L]  COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 1  3  3  4 |----||-------------------------------   4 [S]  COG1689 Uncharacterized protein conserved in archaea
10 19 22 29 |||||||||||--||||-|---|||--||---|-----  38 [S]  COG1690 Uncharacterized conserved protein
 5 10 10 10 |||---||-------|||----||--------------  10 [R]  COG1691 NCAIR mutase (PurE)-related proteins
 6  7  8 17 --------------|---||-|--|-|--------||-  18 [S]  COG1692 Uncharacterized protein conserved in bacteria
 1  5  5  5 |||---||------------------------------   6 [S]  COG1693 Uncharacterized protein conserved in archaea
12 18 27 43 --|--||||||---||||||||||||-|||||---|||  60 [R]  COG1694 Predicted pyrophosphatase
 9 17 22 36 |-|||||-|||----||-||--||||--|-|-|--||- 102 [K]  COG1695 Predicted transcriptional regulators
 6 11 12 18 -----------||---|--|-|-|||-|-----||-|-  22 [M]  COG1696 Predicted membrane protein involved in D-alanine export
 4 11 13 14 ||||-|||||||||------------------------  14 [L]  COG1697 DNA topoisomerase VI, subunit A
 2  8  9 11 |||-||||-||---------------------------  11 [S]  COG1698 Uncharacterized protein conserved in archaea
 4  5  5  9 ---------------|-----|-||---------|---  11 [S]  COG1699 Uncharacterized protein conserved in bacteria
 2  3  3  3 |----|--------|-----------------------   3 [S]  COG1700 Uncharacterized conserved protein
 2  8 10 11 ||||-||||||---------------------------  11 [S]  COG1701 Uncharacterized protein conserved in archaea
 9 12 20 36 -------||-|---|||||---|-||-|||||||-||-  42 [T]  COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase
 6 11 12 19 ---||||--||-------|---|-|---|---|--|--  21 [E]  COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family
 6 10 14 21 -||------------|---|-|--|||||--||--||-  22 [S]  COG1704 Uncharacterized conserved protein
 3  5  8 15 ---------------|--------||-||-|-|---|-  27 [NU] COG1705 Muramidase (flagellum-specific)
 4  7 10 20 --------------||-----|-----||-|-|-|||-  21 [N]  COG1706 Flagellar basal-body P-ring protein
 1  4  4  4 ||----||------------------------------   4 [R]  COG1707 ACT domain-containing protein
 6 13 17 19 |||--||||||---||-------||---|--|----||  91 [R]  COG1708 Predicted nucleotidyltransferases
 2  8 10 12 -||||||||||---------------------------  12 [K]  COG1709 Predicted transcriptional regulator
 1  3  3  4 ||---|--------------------------------   4 [S]  COG1710 Uncharacterized protein conserved in archaea
 1  6  6  8 |-|||||-------------------------------   8 [S]  COG1711 Uncharacterized protein conserved in archaea
 4  9  9  9 |||---|||------|-----------|----|-----   9 [R]  COG1712 Predicted dinucleotide-utilizing enzyme
 6  8  9 17 ---------------|-|||-|-||||-----------  20 [H]  COG1713 Predicted HD superfamily hydrolase involved in NAD metabolism
 5 11 16 27 |------|--------||----|||--|--||||||||  47 [S]  COG1714 Predicted membrane protein/domain
 5  7  7  9 |-||------------|-|---|-----|---------  11 [V]  COG1715 Restriction endonuclease
 8 11 12 16 --------||-||---|||-|-|||----|--------  58 [T]  COG1716 FOG: FHA domain
 4 12 14 16 ||||||||||||||------------------------  17 [J]  COG1717 Ribosomal protein L32E
 6 14 17 19 ||||||||||||||----|--------||---------  20 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control
 3  6  6  6 |||----|------|--|--------------------  22 [R]  COG1719 Predicted hydrocarbon binding protein (contains V4R domain)
 4 12 18 25 ||||-||||||----|-----------||-||-|-||-  28 [S]  COG1720 Uncharacterized conserved protein
10 17 20 29 --|||||-|-|---|||||--||-|--|--|-|--||-  47 [R]  COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
 7 11 19 39 ---------------||-||--||||-|||||||||||  39 [L]  COG1722 Exonuclease VII small subunit
 5  6  6  8 -----------|||--|---|----------------|  11 [S]  COG1723 Uncharacterized conserved protein
 4  7  8  9 --|------------|||----------|-----|||-  13 [N]  COG1724 Predicted periplasmic or secreted lipoprotein
 6  8  9 15 ----|----|-----|||----||||------------  24 [K]  COG1725 Predicted transcriptional regulators
 2  3  6  9 --------------------|------||-||-|----   9 [C]  COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA
 4 12 14 16 ||||||||||||||------------------------  17 [J]  COG1727 Ribosomal protein L18E
 3  4  4  6 ---------------|-----|-||-------------   6 [S]  COG1728 Uncharacterized protein conserved in bacteria
 2  4 10 19 --------------|------------||||-||-|||  19 [S]  COG1729 Uncharacterized protein conserved in bacteria
 4 12 14 16 |||||||||||||-|-----------------------  17 [O]  COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding
 2  6  8  8 |||---|||||---------------------------   8 [H]  COG1731 Archaeal riboflavin synthase
 7 12 14 26 ---|--|---------|-||--||||-||---|-|-|-  32 [M]  COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
 8 18 25 37 |||||-|--||-----||||--||||-||||||-|||- 114 [K]  COG1733 Predicted transcriptional regulators
 5  9 16 30 --------------|-----||-||--|||||||||||  52 [T]  COG1734 DnaK suppressor protein
 5  7  7 12 ---------|--------|---|-|-|-|-------|-  13 [R]  COG1735 Predicted metal-dependent hydrolase with the TIM-barrel fold
 4 12 14 16 ||||||||||||||------------------------  19 [J]  COG1736 Diphthamide synthase subunit DPH2
 4  8 14 28 ---------------|------|||||||-||||-||-  97 [K]  COG1737 Transcriptional regulators
10 14 18 29 --||--|-|-|----|--|||||-|--||-||-|--|-  32 [S]  COG1738 Uncharacterized conserved protein
 9 16 21 36 --||-------||--|--||-||||||||-|||||-|-  38 [S]  COG1739 Uncharacterized conserved protein
 5  7  7 12 --|---|-------|-|------|----|-----|---  21 [C]  COG1740 Ni,Fe-hydrogenase I small subunit
 6 10 14 24 --|-|---|-------||----||---||-|||--||-  45 [R]  COG1741 Pirin-related protein
 5  7  9 17 --|--------------|----|-|--||---|--||-  17 [S]  COG1742 Uncharacterized conserved protein
 4  6  6  7 -----|||--|----|--------------------|-  10 [L]  COG1743 Adenine-specific DNA methylase containing a Zn-ribbon
 8 14 16 28 ---|-||-|-|----||-|--|-|||||----|---|-  54 [R]  COG1744 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein
 1  6  6  6 ||||--||------------------------------   9 [R]  COG1745 Predicted metal-binding protein
 2  9 11 13 |||||||||||---------------------------  13 [J]  COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme)
 2  2  2  4 --------------------||----------------   4 [S]  COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA
 7 13 16 22 ----|||-|-|||---|||-----||----||--|-|-  26 [E]  COG1748 Saccharopine dehydrogenase and related proteins
 4  8 11 22 --------------|------|-||--||-|-|-|||-  27 [N]  COG1749 Flagellar hook protein FlgE
 2  5  7  8 -||--||-|||---------------------------   9 [R]  COG1750 Archaeal serine proteases
 2  5  5  5 |||---|--------|----------------------   5 [S]  COG1751 Uncharacterized conserved protein
10 13 20 31 -----------|||||-|-|-||-||-||||-||-|||  68 [R]  COG1752 Predicted esterase of the alpha-beta hydrolase superfamily
 1  4  4  5 -||--||-------------------------------   8 [S]  COG1753 Uncharacterized conserved protein
 5  7  9 16 ----------------|||--||------|-----|||  16 [R]  COG1754 Uncharacterized C-terminal domain of topoisomerase IA
 4  5  6 12 ------------------|---|-||-----|-|----  12 [S]  COG1755 Uncharacterized protein conserved in bacteria
 4  9 11 13 -|--||||||||||------------------------  13 [S]  COG1756 Uncharacterized conserved protein
 6 10 12 20 ---|-|----|--------|-|-||---|-||-||---  43 [C]  COG1757 Na+/H+ antiporter
12 25 35 58 |||||||||||||||||||--|||||-|||||||||||  58 [K]  COG1758 DNA-directed RNA polymerase, subunit K/omega
 2  7  8  9 |||--|||||----------------------------  15 [R]  COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)
 5  9 15 34 ------------------||--||||-||-|||||||-  58 [E]  COG1760 L-serine deaminase
 4 12 14 16 ||||||||||||||------------------------  20 [K]  COG1761 DNA-directed RNA polymerase, subunit L
 6 10 16 34 -------------------||||||||||-||||-||- 127 [GT] COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)
 5 15 19 31 |||||||||||---|---------|---|-|||-|-|-  33 [H]  COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein
 5  8 13 23 ----|-------------|---|-|||||||-|--||-  39 [O]  COG1764 Predicted redox protein, regulator of disulfide bond formation
 8 16 21 34 -||-||-|-||---||--|---|||-|||-|-||-||-  44 [O]  COG1765 Predicted redox protein, regulator of disulfide bond formation
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  27 [NU] COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein
 5 10 14 18 |||--|||-||--------|-----|-||-||------  22 [H]  COG1767 Triphosphoribosyl-dephospho-CoA synthetase
 3  3  3  4 ------------------|-|--|--------------   4 [R]  COG1768 Predicted phosphohydrolase
 3  3  3  3 ------|-------||----------------------   3 [L]  COG1769 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
 4  5 10 21 ----------------|-----|--|-||||----|||  23 [E]  COG1770 Protease II
 1  3  3  4 ||---|--------------------------------   4 [S]  COG1771 Uncharacterized protein conserved in archaea
 1  5  5  6 -||--|||------------------------------   6 [S]  COG1772 Uncharacterized protein conserved in archaea
 8 14 17 22 ||---||--------|||-|-|||---|||--||-|--  33 [C]  COG1773 Rubredoxin
 8 10 11 14 -----------|||||--||-|-|||------------  16 [S]  COG1774 Uncharacterized homolog of PSP1
 4  6  6  8 -|----||-----------|---|----|---------  10 [E]  COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB
 5 10 10 15 --||-||--------|-----|-||-----|---|---  25 [NT] COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
 1  6  6  8 |-|||||-------------------------------  10 [K]  COG1777 Predicted transcriptional regulators
 4  6 11 19 --|-----------|----|-------||||||||---  19 [R]  COG1778 Low specificity phosphatase (HAD superfamily)
 3 10 12 14 |||-|||||||||-------------------------  14 [R]  COG1779 C4-type Zn-finger protein
 4  6  7 20 ------------------|---|-|||-|-------|-  22 [F]  COG1780 Protein involved in ribonucleotide reduction
 5 13 16 24 |||||||||||----|-------|----|-|--|----  24 [F]  COG1781 Aspartate carbamoyltransferase, regulatory subunit
 2  9 11 13 |||||||||||---------------------------  14 [R]  COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain
 3  3  4  5 ---------------------|--||-----|------   7 [R]  COG1783 Phage terminase large subunit
 1  7  7  8 ||||-|||------------------------------   8 [S]  COG1784 Predicted membrane protein
 8 13 15 20 --||-|-----||--||-|---|-|--|||--|---|-  22 [P]  COG1785 Alkaline phosphatase
 3  9 10 13 |||--||||-|----------------|--------|-  13 [S]  COG1786 Uncharacterized conserved protein
 5  5  5  6 ---------------|-||-----|---------|---   6 [V]  COG1787 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes
 7 11 16 23 ------|--|--------||--||||-||--||-||||  35 [I]  COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit
 1  4  4  4 ||----||------------------------------   4 [S]  COG1790 Uncharacterized protein conserved in archaea
 5  6  7  7 -----------||-|-|-------|--|-|--------   7 [S]  COG1791 Uncharacterized conserved protein, contains double-stranded beta-helix domain
 7 11 17 31 --------------|-|--|||-|||-||||||-||-|  33 [M]  COG1792 Cell shape-determining protein
 8 19 24 31 |||||||||||||||-------|-|--|--||-||||-  66 [L]  COG1793 ATP-dependent DNA ligase
 3  7 10 17 -----||-----------------||--|--||-|||-  22 [M]  COG1794 Aspartate racemase
 2  6  6  6 |||---||--------------------|---------   7 [S]  COG1795 Uncharacterized conserved protein
 5  8  8 12 |-|-|------||-|---|-----|-------------  12 [L]  COG1796 DNA polymerase IV (family X)
 8 18 20 26 |||||-||||------||||--|||--||---|---|-  28 [H]  COG1797 Cobyrinic acid a,c-diamide synthase
 4 12 14 16 ||||||||||||||------------------------  16 [J]  COG1798 Diphthamide biosynthesis methyltransferase
 4  6  7 15 ----------------||-|--||||------------  16 [S]  COG1799 Uncharacterized protein conserved in bacteria
 1  3  3  3 -|---||-------------------------------   6 [R]  COG1800 Predicted transglutaminase-like proteases
 8 13 19 30 --|-|||-|||---|||-|-----|--||-|||--||-  39 [S]  COG1801 Uncharacterized conserved protein
 8 11 16 30 ----|----|-----|--||--||||-||-|-||-||- 143 [K]  COG1802 Transcriptional regulators
 5  8 10 19 ---------------|-|---|-||---|-|||---|-  19 [G]  COG1803 Methylglyoxal synthase
 5  8 11 18 ----|-|-||--------|---|----||---|--||-  56 [C]  COG1804 Predicted acyl-CoA transferases/carnitine dehydratase
 3  6  9 12 ----------------||--|------||-||-|--|-  12 [C]  COG1805 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB
 3  5 11 23 ------------------|-----|--||||-||-|||  24 [S]  COG1806 Uncharacterized protein conserved in bacteria
 6 11 15 24 -----||-------|-||-|---||--|||--||-||-  44 [M]  COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
 4  8  8  8 -|||--|---|-----||-------|------------  11 [S]  COG1808 Predicted membrane protein
 3  5  5  5 ||-----|--------------|-|-------------   5 [S]  COG1809 Uncharacterized conserved protein
 1  5  5  5 |||---||------------------------------  12 [S]  COG1810 Uncharacterized protein conserved in archaea
 6  7  7 12 ------|--------|--||---||---|---------  13 [R]  COG1811 Uncharacterized membrane protein, possible Na+ channel or pump
 4 11 13 15 |||||||||||---|----------|------------  16 [E]  COG1812 Archaeal S-adenosylmethionine synthetase
 4 12 14 16 ||||||||||||||------------------------  17 [K]  COG1813 Predicted transcription factor, homolog of eukaryotic MBF1
 9 16 19 21 ||--|||||||||--|--|-|-|--|-|-------||-  30 [S]  COG1814 Uncharacterized membrane protein
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  26 [N]  COG1815 Flagellar basal body protein
 6 10 13 19 -----------||---|----|||-|-||-|-|--||-  24 [F]  COG1816 Adenosine deaminase
 2  5  5  6 |||--|--|-----------------------------   8 [S]  COG1817 Uncharacterized protein conserved in archaea
 3  7  9 10 ||---|||||||--------------------------  17 [R]  COG1818 Predicted RNA-binding protein, contains THUMP domain
 7 12 14 19 |||----|---|-----||---|||--||-|-----|-  38 [GC] COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
 9 12 18 33 ---------|-----||-||-|||||||||||---||-  41 [G]  COG1820 N-acetylglucosamine-6-phosphate deacetylase
 1  5  5  5 |||---||------------------------------   5 [R]  COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)
 1  3  3  4 ||---|--------------------------------   8 [S]  COG1822 Predicted archaeal membrane protein
 3  4  6 12 ---------------------|--|---|-||--|---  13 [R]  COG1823 Predicted Na+/dicarboxylate symporter
 2  7  7  8 |-||-|||--|---------------------------  11 [P]  COG1824 Permease, similar to cation transporters
 9 13 20 41 --------------|||||-|||-|--|||||||||||  41 [J]  COG1825 Ribosomal protein L25 (general stress protein Ctc)
 8 16 25 44 --|||-|||||---|-|||---|-|--|||||||||||  86 [U]  COG1826 Sec-independent protein secretion pathway components
 4  6  7 10 |------|-------|---|---|||------------  14 [R]  COG1827 Predicted small molecule binding protein (contains 3H domain)
 9 18 21 31 ||||||||||----|||||---|-||--------|||-  31 [F]  COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component
 2  8 10 11 ||||-||||||---------------------------  11 [R]  COG1829 Predicted archaeal kinase (sugar kinase superfamily)
 6 13 15 23 ||||-|||-||---|-|---|-------|--|----|-  33 [G]  COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes
 2  9 10 12 |||||||||-|---------------------------  12 [R]  COG1831 Predicted metal-dependent hydrolase (urease superfamily)
 7 12 15 27 ---|||--|||---||--|-----||--|---|-|-|-  27 [R]  COG1832 Predicted CoA-binding protein
 3 10 11 12 ||||||||||-----|----------------------  12 [S]  COG1833 Uncharacterized conserved protein
 6  9  9 12 --|-------|-----||----|||--|--------|-  14 [E]  COG1834 N-Dimethylarginine dimethylaminohydrolase
 7  9 16 29 --|-------------|-||--|-||-|||-|||-|||  83 [I]  COG1835 Predicted acyltransferases
 4 11 11 13 |||||||-|-------||------|-------------  13 [S]  COG1836 Predicted membrane protein
10 12 13 23 --------------||||||||||||--------|---  25 [R]  COG1837 Predicted RNA-binding protein (contains KH domain)
 6 14 18 25 |||--||||-----||-------||--||||-||--|-  38 [C]  COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain
 5  8 10 13 |---|||-|||----|------|---------|-----  13 [S]  COG1839 Uncharacterized conserved protein
 7 12 19 29 --||----|-|-----||-|--|-||-||||||||-|-  74 [P]  COG1840 ABC-type Fe3+ transport system, periplasmic component
12 23 33 54 ||||||||||||||||--||-|||||-|||||||-|||  60 [J]  COG1841 Ribosomal protein L30/L7E
 7 10 13 21 --|-----------|-|||---|||--||-|----||-  30 [KT] COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  26 [N]  COG1843 Flagellar hook capping protein
 1  5  5  6 |||--|-|------------------------------   6 [S]  COG1844 Uncharacterized protein conserved in archaea
 9 12 18 33 ---|----||||--|-|||---|-|--|||--|--|||  56 [C]  COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3
 9 19 27 45 |||||||||||----||-||--||||-||||-||-||- 336 [K]  COG1846 Transcriptional regulators
 7  9 10 17 ---------------|||||-|||||------------  17 [R]  COG1847 Predicted RNA-binding protein
 5  7  9 11 -|---||-|||-------|---|-------------|-  87 [R]  COG1848 Predicted nucleic acid-binding protein, contains PIN domain
 2  9 11 13 |||||||||||---------------------------  13 [S]  COG1849 Uncharacterized protein conserved in archaea
 4  8  8 10 -||--||---------||------|-----------|-  12 [G]  COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit
 2  3  3  4 -|---|--------|-----------------------   4 [S]  COG1851 Uncharacterized conserved protein
 2  6  6  6 |||--||------------|------------------   7 [S]  COG1852 Uncharacterized conserved protein
11 19 27 44 |-|-|||-|||-|-||||||--||||-||--|||-||| 100 [R]  COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family
 4  7 10 23 ------------------|--|-|||--|-||-||---  23 [T]  COG1854 LuxS protein involved in autoinducer AI2 synthesis
 2  9 11 13 |||||||||||---------------------------  13 [R]  COG1855 ATPase (PilT family)
 4  4  4  5 -----|---|----||----------------------   5 [S]  COG1856 Uncharacterized homolog of biotin synthetase
 4  8 10 11 |||--||-|||---|----|------------------  17 [L]  COG1857 Uncharacterized protein predicted to be involved in DNA repair
 4  7 10 17 --|-----------|---|--------||-|||-|-|-  24 [P]  COG1858 Cytochrome c peroxidase
 6 12 14 18 --|-|||||-|||-----||-------||-------|-  19 [J]  COG1859 RNA:NAD 2'-phosphotransferase
 2  8  8  9 |||||||-|-----------------------------   9 [S]  COG1860 Uncharacterized protein conserved in archaea
 5  6  6  6 -|-----------------|-|-||----------|--   7 [M]  COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog
 8 12 20 42 --------------||---|||||||-|||||||||||  43 [U]  COG1862 Preprotein translocase subunit YajC
 6 11 13 20 ||||-|---------|--|---|-|--|--|-----||  30 [P]  COG1863 Multisubunit Na+/H+ antiporter, MnhE subunit
 6 10 11 13 --|--------||---|--|-|-----||---|-||--  15 [F]  COG1864 DNA/RNA endonuclease G, NUC1
 3  9 11 14 -||||||||||-------------|-------------  14 [S]  COG1865 Uncharacterized conserved protein
 6  8 11 21 ----------||------||----|--||-||--|-|-  21 [C]  COG1866 Phosphoenolpyruvate carboxykinase (ATP)
 5 13 15 17 |||||||||||||||-----------------------  18 [J]  COG1867 N2,N2-dimethylguanosine tRNA methyltransferase
 5  9 11 24 --------------||-----|-||--||-|-|-|-|-  24 [N]  COG1868 Flagellar motor switch protein
 4  5  8 15 ---------------|------|-|||-|-||------  16 [G]  COG1869 ABC-type ribose transport system, auxiliary component
 5 11 13 16 --||-||--------|-----|-||--|--|-|--||-  17 [NT] COG1871 Chemotaxis protein; stimulates methylation of MCP proteins
 6 12 16 23 |||--|||--|-----|---|-|-----|-||---|||  23 [S]  COG1872 Uncharacterized conserved protein
 2 10 10 13 ||||||||---------------||-------------  25 [S]  COG1873 Uncharacterized conserved protein
 4  6  9 11 -----|---------|-------|||--||-----||-  15 [G]  COG1874 Beta-galactosidase
 5  6  8 13 ---------------|----|-|-|--|-||-|-----  14 [T]  COG1875 Predicted ATPase related to phosphate starvation-inducible protein PhoH
 4  6 10 16 ----------------||---|-|||--||||------  18 [M]  COG1876 D-alanyl-D-alanine carboxypeptidase
 6 10 10 17 |---|---|--|||--------|-----|---|---|-  24 [G]  COG1877 Trehalose-6-phosphatase
 7 16 18 25 |||||||-||-----|||----|-|--|---||---|-  30 [R]  COG1878 Predicted metal-dependent hydrolase
 7 10 15 25 --|------------|---|-|||||-||-|||--||- 183 [G]  COG1879 ABC-type sugar transport system, periplasmic component
 1  5  5  5 |||---||------------------------------   7 [C]  COG1880 CO dehydrogenase/acetyl-CoA synthase epsilon subunit
 8 18 23 37 |-|||||--|-|--|-----|-|||-|-|||||||-||  44 [R]  COG1881 Phospholipid-binding protein
 4  7 10 18 |-----|------------|---|||--|-|||-----  34 [C]  COG1882 Pyruvate-formate lyase
 6  7  9 10 -----||--------|---|-|---|--|-||------  14 [C]  COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit
 6 11 13 23 ---||||--||-------|---|-|---|---|--||-  36 [I]  COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit
 1  6  6  7 -|||-|||------------------------------   8 [S]  COG1885 Uncharacterized protein conserved in archaea
 6 10 13 27 --------------||----||-||--||-|-|-|||-  45 [NU] COG1886 Flagellar motor switch/type III secretory pathway protein
 3  4  6  8 |----|------------------||-|-|--------  22 [M]  COG1887 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC
 2  7  9 11 ||--|||||||---------------------------  11 [S]  COG1888 Uncharacterized protein conserved in archaea
 4 12 14 16 ||||||||||||||------------------------  16 [J]  COG1889 Fibrillarin-like rRNA methylase
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG1890 Ribosomal protein S3AE
 1  5  5  5 |||---||------------------------------   5 [S]  COG1891 Uncharacterized protein conserved in archaea
 2  7  8  9 |-||-|||||----------------------------   9 [S]  COG1892 Uncharacterized protein conserved in archaea
 8 14 19 30 ---|-||-|-|||-|-|-----||||-||-|-|--||-  44 [H]  COG1893 Ketopantoate reductase
 8 11 16 27 |-----------|-|||||---|----|||--||-|||  33 [C]  COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit
 2  5  5  5 -||--||--------|----------------------   6 [S]  COG1895 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
 6 12 18 29 ---|-||||||||-----|-----|--||-||--|||-  31 [R]  COG1896 Predicted hydrolases of HD superfamily
 3  6  8 16 ---------------|-------|||--|-|---|-|-  16 [E]  COG1897 Homoserine trans-succinylase
 8 17 24 37 |-|-|||--||-----||||--||||-|||-||||||-  47 [M]  COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes
 6 14 16 18 ||||||||||||||--|------------------|--  20 [O]  COG1899 Deoxyhypusine synthase
 2  7  7  7 |||---||--------||--------------------  11 [S]  COG1900 Uncharacterized conserved protein
 3  8  9 10 -|||-||||-|-------------------|-------  10 [S]  COG1901 Uncharacterized conserved protein
10 18 23 37 --|||-|--|-||--||-||--|||||||||-|--||-  95 [C]  COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family
 6 15 17 19 |||-|-||||------||-|---||--||---|---|-  19 [H]  COG1903 Cobalamin biosynthesis protein CbiD
 4  6  8 15 ---------------|------||||--|------||-  16 [G]  COG1904 Glucuronate isomerase
 8 11 16 27 |-----------|-|||||---|----|||--||-|||  34 [C]  COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit
 3  4  4  5 -----||-|------|----------------------   5 [S]  COG1906 Uncharacterized conserved protein
 2  7  8  9 |||--|||-||---------------------------  13 [R]  COG1907 Predicted archaeal sugar kinases
 1  5  5  5 |||---||------------------------------   9 [C]  COG1908 Coenzyme F420-reducing hydrogenase, delta subunit
 2  8 10 12 |||-|||||||---------------------------  12 [S]  COG1909 Uncharacterized protein conserved in archaea
 4  9  9 10 -||||-|-|--------------||-------|-----  12 [P]  COG1910 Periplasmic molybdate-binding protein/domain
 4 10 12 13 |||--|||||||||------------------------  14 [J]  COG1911 Ribosomal protein L30E
 7 13 16 20 -|||-||||||---|||-------||--|-----|---  20 [S]  COG1912 Uncharacterized conserved protein
 3  7  9 10 -|-|-||||||---|-----------------------  12 [R]  COG1913 Predicted Zn-dependent proteases
 9 13 18 35 ----|----|-||---|-||--||||-|||-|||--|-  50 [P]  COG1914 Mn2+ and Fe2+ transporters of the NRAMP family
 2  6  6  6 ||----||--------||--------------------   6 [S]  COG1915 Uncharacterized conserved protein
 3  9  9 11 ||||-|||-------------|-------|--------  11 [S]  COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein)
 9 19 22 34 ||||||--||----||||-|--||||-||---|-|-|-  58 [S]  COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain
 6 15 19 25 |||--|||-------|-||----|||-||||-|-||--  29 [P]  COG1918 Fe2+ transport system protein A
 2  7  7  9 ||||--||--------------|---------------   9 [S]  COG1920 Uncharacterized conserved protein
 3  8 10 19 ||--|--|------|------------||--|--|-|-  21 [E]  COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]
 6  9 12 20 ---------------||||--|-||---|||----||-  23 [M]  COG1922 Teichoic acid biosynthesis proteins
 5  8 14 25 -|------------||-------||--|||||||-||-  25 [R]  COG1923 Uncharacterized host factor I protein
 6 11 12 14 |||---||------||---|---|||--|---------  19 [I]  COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)
 7 11 18 38 ------------------||||||||||||||||-||-  76 [G]  COG1925 Phosphotransferase system, HPr-related proteins
 5  8  8 12 --|-|---------|-|-----|---------|-|-|-  16 [R]  COG1926 Predicted phosphoribosyltransferases
 1  5  5  5 |||---||------------------------------   5 [C]  COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase
 4  6  6  9 -----------|||--||----|---------------  17 [O]  COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase
 4  6 10 23 -----------------|----||||-||-||-|----  31 [G]  COG1929 Glycerate kinase
 4  8  8  8 ||||--|---------|-------|---|---------   8 [P]  COG1930 ABC-type cobalt transport system, periplasmic component
 2  8 10 11 ||||-||||||---------------------------  11 [S]  COG1931 Uncharacterized protein conserved in archaea
 6 10 17 32 --|--------||---|-----|-||-||||||||||-  32 [HE] COG1932 Phosphoserine aminotransferase
 1  8  8 10 ||||||||------------------------------  12 [L]  COG1933 Archaeal DNA polymerase II, large subunit
 3  7 13 24 --------------|-||---------||||||||||-  24 [S]  COG1934 Uncharacterized protein conserved in bacteria
 1  5  5  6 -||--|||------------------------------   6 [S]  COG1935 Uncharacterized conserved protein
 4 12 14 16 ||||||||||||||------------------------  16 [F]  COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)
 5 10 12 22 ----------------|||---||||-||---|-|-|-  38 [S]  COG1937 Uncharacterized protein conserved in bacteria
 2  9 11 13 |||||||||||---------------------------  17 [R]  COG1938 Archaeal enzymes of ATP-grasp superfamily
 4  6  7 12 ---------------|||-|---|||------------  12 [S]  COG1939 Uncharacterized protein conserved in bacteria
11 17 22 39 ---||-|-|-|---||||||-||||||-|-||---||- 155 [KG] COG1940 Transcriptional regulator/sugar kinase
 2  8  8  9 |||--|||--------||--------------------  16 [C]  COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit
 5  9 13 26 |-----|---------|-----|-||--||--|||||-  33 [R]  COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog
 9 15 21 28 --|||----|-----||-||--||||-||-|||||||- 153 [L]  COG1943 Transposase and inactivated derivatives
 3  8 10 18 ||||---|--------------|----||--|----|-  20 [S]  COG1944 Uncharacterized conserved protein
 2  9  9 12 ||||||||------------|-----------------  15 [S]  COG1945 Uncharacterized conserved protein
 4  5 10 21 -----------|-|--------|----|||||---||-  25 [I]  COG1946 Acyl-CoA thioesterase
10 16 22 40 --------------|||||||||||-|||||||||||-  40 [I]  COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase
 4 11 13 14 ||||-|||||||||------------------------  18 [L]  COG1948 ERCC4-type nuclease
 3  5 10 20 -----------||---------|----|||||||----  20 [A]  COG1949 Oligoribonuclease (3'->5' exoribonuclease)
 5  6  6 11 ----------------|||---|-|-------|-----  13 [S]  COG1950 Predicted membrane protein
 6 14 18 25 |||--||||-----||-------||--||||-||--|-  37 [C]  COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain
 2  4 11 22 -|-------------------------|||||||-|||  22 [U]  COG1952 Preprotein translocase subunit SecB
 4  7 10 16 ---------||||-----------|--||---|--||-  25 [FH] COG1953 Cytosine/uracil/thiamine/allantoin permeases
 4  5  5 10 ---------------|---|---||---|---------  12 [K]  COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding)
 2  7  8 10 -||||||--||---------------------------  11 [NU] COG1955 Archaeal flagella assembly protein J
 5  9 15 26 ---||------|---|-------|||-|||||-|-||-  26 [T]  COG1956 GAF domain-containing protein
 7 11 14 23 ---------|-||---|-|---|-|--||--||-|||-  47 [F]  COG1957 Inosine-uridine nucleoside N-ribohydrolase
 4 11 13 15 |-||||||||||||------------------------  66 [K]  COG1958 Small nuclear ribonucleoprotein (snRNP) homolog
 8 13 21 36 --------------||||||--||||-|||||||||||  86 [K]  COG1959 Predicted transcriptional regulator
 9 14 20 34 ---||-|-||||----|-||--|||--||-|-||-||- 309 [I]  COG1960 Acyl-CoA dehydrogenases
 7 12 17 30 ----||--|-------|||---||||-||||-|--||-  84 [L]  COG1961 Site-specific recombinases, DNA invertase Pin homologs
 1  5  5  5 |||---||------------------------------   6 [H]  COG1962 Tetrahydromethanopterin S-methyltransferase, subunit H
 5  6  7 10 ---------------||||--|--||------------  10 [S]  COG1963 Uncharacterized protein conserved in bacteria
 3  9 11 14 |||-|||||||-----------|---------------  16 [R]  COG1964 Predicted Fe-S oxidoreductases
 3  6 10 18 -----------|||-------------||-||||---|  18 [P]  COG1965 Protein implicated in iron transport, frataxin homolog
 7 11 17 28 --|--|--|-|---|----|--||||-||-|||||---  34 [T]  COG1966 Carbon starvation protein, predicted membrane protein
 1  6  6  7 ||||-||-------------------------------  10 [S]  COG1967 Predicted membrane protein
11 17 24 40 |------|||----||||||-|||||-||||-|||||-  45 [V]  COG1968 Uncharacterized bacitracin resistance protein
 2  3  3  8 --------------|-------------|-----|---   9 [C]  COG1969 Ni,Fe-hydrogenase I cytochrome b subunit
 7  9 15 30 --|--------------|||--|-||-||||||--||-  33 [M]  COG1970 Large-conductance mechanosensitive channel
 5  9 11 17 |-|----------------|--|||--|||---||---  21 [S]  COG1971 Predicted membrane protein
 3  5  8 16 ----------------|-------||--|-||--||--  29 [F]  COG1972 Nucleoside permease
 2  6  6  6 |||---||-|----------------------------   6 [O]  COG1973 Hydrogenase maturation factor
 6 10 16 30 ---------------||||---||||-||||||--||-  50 [KT] COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases)
 5  7 11 18 --------|||-------|---|-|--||---|--||-  34 [O]  COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family
 4 12 14 16 ||||||||||||||------------------------  16 [J]  COG1976 Translation initiation factor 6 (eIF-6)
 8 16 21 36 --|||||-||----|-|||---|-|--||-|||-|||-  56 [H]  COG1977 Molybdopterin converting factor, small subunit
 3  4  4  4 --------------||-------||-------------   4 [S]  COG1978 Uncharacterized protein conserved in bacteria
 5  6  8 14 ---------------||--|---||---|-||------  17 [C]  COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family
 3  8 10 12 ||--|||||||---|-----------------------  12 [G]  COG1980 Archaeal fructose 1,6-bisphosphatase
 2  6 10 17 ----------------||---------|-|--||||||  17 [S]  COG1981 Predicted membrane protein
 5  9 13 23 ----------------||-|--||||-||-|||---|-  46 [E]  COG1982 Arginine/lysine/ornithine decarboxylases
 5  7  9 18 --|--|---------|------||||--|-|-------  24 [KT] COG1983 Putative stress-responsive transcriptional regulator
 7 10 15 26 -----|-----|------||--|-|--||-|||||||-  31 [E]  COG1984 Allophanate hydrolase subunit 2
12 23 32 51 ||||--|||||||-|||||||-||||-||||||||||-  61 [H]  COG1985 Pyrimidine reductase, riboflavin biosynthesis
 4  8 11 16 ||--|-|||||-------------|---|-|-------  16 [S]  COG1986 Uncharacterized conserved protein
 5  9 12 25 --------------||-----|-||--||-|-|-|||-  26 [NU] COG1987 Flagellar biosynthesis pathway, component FliQ
 4 10 12 20 |||--|||--|------------||--||--|------  35 [R]  COG1988 Predicted membrane-bound metal-dependent hydrolases
 8 19 26 40 ||||-|||------|||||---||||-||||||||||-  50 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
 5 13 15 17 ||||||||||||||--------|---------------  17 [S]  COG1990 Uncharacterized conserved protein
 1  4  4  5 ||---|-|------------------------------   9 [S]  COG1991 Uncharacterized conserved protein
 3  8 10 11 ||||-|-||||----|----------------------  17 [S]  COG1992 Uncharacterized conserved protein
 5  8  9 11 -||--|-|------||------|------------||-  13 [S]  COG1993 Uncharacterized conserved protein
 9 21 25 32 |||||||||||---|||||---|||-----|-|||||-  43 [R]  COG1994 Zn-dependent proteases
 5  9 15 25 --------------|-||-|----|--||||||||||-  30 [H]  COG1995 Pyridoxal phosphate biosynthesis protein
 4 12 14 16 |||||||||||||----------|--------------  16 [K]  COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger)
 4 12 14 16 ||||||||||||||------------------------  19 [J]  COG1997 Ribosomal protein L37AE/L43A
 3 11 13 15 |||||||||||||-------------------------  16 [J]  COG1998 Ribosomal protein S27AE
 7 11 17 23 ---|----|-|||-|---|-----|--|-||-||||||  37 [R]  COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems
 2  4  4  4 ||-----|-------|----------------------   4 [R]  COG2000 Predicted Fe-S protein
 5  9 15 31 ------------------|--||||-||||-|||-|||  31 [S]  COG2001 Uncharacterized protein conserved in bacteria
 6 11 13 21 ---|-||-|||-----||----|||---|-------|-  47 [K]  COG2002 Regulators of stationary/sporulation gene expression
 7 11 18 32 --|-----------||||-|---|||-|||||||--||  45 [L]  COG2003 DNA repair proteins
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG2004 Ribosomal protein S24E
 3  9 13 20 |-|---||||-----------------||--||-|||-  22 [R]  COG2005 N-terminal domain of molybdenum-binding protein
 3  6  6  6 |-|---|--------|||--------------------   9 [S]  COG2006 Uncharacterized conserved protein
 4 12 14 16 ||||||||||||||------------------------  21 [J]  COG2007 Ribosomal protein S8E
 8 12 15 24 ---|-------||--||-||---||--||-|-|--||-  27 [E]  COG2008 Threonine aldolase
 8 14 21 38 ---||-|-|-|||-----|-|-|-|--||||-||||||  40 [C]  COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit
 6 11 14 24 --|---|---------|||---|-|--|--|-|||||-  78 [C]  COG2010 Cytochrome c, mono- and diheme variants
 7 11 18 34 ------------------||||||||-||||||||||-  39 [P]  COG2011 ABC-type metal ion transport system, permease component
 4 12 14 16 ||||||||||||||------------------------  16 [K]  COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5
 7 15 17 19 |-||||||-||----|-||----|-|-|-------||-  29 [S]  COG2013 Uncharacterized conserved protein
 1  4  4  5 |||--|--------------------------------   5 [S]  COG2014 Uncharacterized conserved protein
 3  4  6  9 -----------|----------|----||-|----|--   9 [Q]  COG2015 Alkyl sulfatase and related hydrolases
 4 12 14 16 ||||||||||||||------------------------  16 [J]  COG2016 Predicted RNA-binding protein (contains PUA domain)
 9 14 19 32 ----|----|-||--|||||---|||--|-||||-||-  58 [G]  COG2017 Galactose mutarotase and related enzymes
 5  8  8 10 ||----||------|---|---|----------|----  19 [R]  COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid
 3  7  9 11 ||--||-||||-------------------------|-  12 [F]  COG2019 Archaeal adenylate kinase
 8 14 15 20 --|--||---||||--||----||------|||---|-  39 [O]  COG2020 Putative protein-S-isoprenylcysteine methyltransferase
 6 11 15 21 |-||-------||-----|---|-|--|-|-|||-||-  25 [E]  COG2021 Homoserine acetyltransferase
 7 12 17 29 --------------|-||||--|||--||||-|||||-  29 [H]  COG2022 Uncharacterized enzyme of thiazole biosynthesis
 4 12 13 15 ||||||||-|||||------------------------  15 [J]  COG2023 RNase P subunit RPR2
 1  5  5  5 |||---||------------------------------   5 [J]  COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type)
 9 15 21 33 ---||-|-|||||--|--||--|||--|||--||-||-  57 [C]  COG2025 Electron transfer flavoprotein, alpha subunit
 7 13 14 18 -||--||---|-----||-|--|--|--|-|-|---|-  39 [JD] COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system
 6  8 13 22 --|-------------|||---|-|--|||||||----  25 [M]  COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)
 1  3  3  4 -|---||-------------------------------   4 [S]  COG2028 Uncharacterized conserved protein
 1  5  5  6 |||--|-|------------------------------   6 [S]  COG2029 Uncharacterized conserved protein
 8 12 15 24 ---|--|--|-||-----||--|-|--||-|-|--||-  79 [I]  COG2030 Acyl dehydratase
 6  7 10 11 ------|---|--------|--|-||-||--|--|---  12 [I]  COG2031 Short chain fatty acids transporter
 7 11 15 23 --|--------||-|---|---|||---|-||||-||-  31 [P]  COG2032 Cu/Zn superoxide dismutase
 4  8  8  9 |||--||--------|-----|-|--------------  10 [C]  COG2033 Desulfoferrodoxin
 2  8  9 11 |||-||||-||---------------------------  12 [S]  COG2034 Predicted membrane protein
 7  8  9 12 |--|-----------|---|-||-||----|-------  12 [S]  COG2035 Predicted membrane protein
 3 10 10 11 ||||-|||---|||------------------------  40 [B]  COG2036 Histones H3 and H4
 1  5  5  5 |||---||------------------------------   8 [C]  COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase
 8 19 24 35 |||||||||||-----||||--|||--||-|-|--||-  36 [H]  COG2038 NaMN:DMB phosphoribosyltransferase
 7  8  9 14 -----|---|--------||--|-||--|---|-----  17 [O]  COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)
 5  8  8 11 -----------||----|----|||---|-------|-  13 [E]  COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)
 8 14 19 29 --|||-|-|||---|-|-|---|-|--||--||-|||-  43 [R]  COG2041 Sulfite oxidase and related enzymes
 4 10 10 11 |||||--|-|-|||------------------------  11 [S]  COG2042 Uncharacterized conserved protein
 1  5  5  5 |||---||------------------------------  14 [S]  COG2043 Uncharacterized protein conserved in archaea
 4  7  8  8 ||----||||----|------------|----------  13 [R]  COG2044 Predicted peroxiredoxins
 6 11 11 12 ||--|--|-------||||----||-------|-----  12 [HR] COG2045 Phosphosulfolactate phosphohydrolase and related enzymes
 8 11 13 14 -----||-|||||-|-|||-----|---------|---  16 [P]  COG2046 ATP sulfurylase (sulfate adenylyltransferase)
 1  8  8 10 ||||||||------------------------------  10 [R]  COG2047 Uncharacterized protein (ATP-grasp superfamily)
 5 10 10 10 |||---||-|----|-||----------------|---  17 [C]  COG2048 Heterodisulfide reductase, subunit B
 7 10 15 25 -----|-----|------||--|-|--||-|||||||-  30 [E]  COG2049 Allophanate hydrolase subunit 1
 8 15 21 40 --|||||-||--|-|---|---|-||-||-|||-|||-  88 [Q]  COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism
 4 12 14 16 ||||||||||||||------------------------  17 [J]  COG2051 Ribosomal protein S27E
 3  5  5  6 ---------------|||-----||-------------   6 [S]  COG2052 Uncharacterized protein conserved in bacteria
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG2053 Ribosomal protein S28E/S33
 1  5  5  5 |||---||------------------------------   5 [R]  COG2054 Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases
 4  9 11 19 ||---|-|--------------|||--||--|----|-  32 [C]  COG2055 Malate/L-lactate dehydrogenases
 3  5  7 13 -------------------|----|--|--||-||---  15 [R]  COG2056 Predicted permease
 6 10 15 22 ---------|--------||--||||-||--||-||||  32 [I]  COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit
 4 12 14 16 ||||||||||||||------------------------  24 [J]  COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2
 9 13 15 18 -|-------------|||||-||-|-||--|-|--||-  27 [P]  COG2059 Chromate transport protein ChrA
 6 11 13 22 ---||-----------|||---|||--||---|--||-  26 [P]  COG2060 K+-transporting ATPase, A chain
 1  5  5  5 |||---||------------------------------   5 [E]  COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase
 6 10 17 28 ------|-|||---|-||----|----||||||-|||-  31 [T]  COG2062 Phosphohistidine phosphatase SixA
 3  6  9 19 --------------||-----------||-|-|-|||-  20 [N]  COG2063 Flagellar basal body L-ring protein
 5 14 19 24 |||||||||||-----------||---||--||--||-  44 [NU] COG2064 Flp pilus assembly protein TadC
 6  9 11 19 ----------------||||--||||-|---||-----  19 [F]  COG2065 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase
 5  8 11 19 ----------------||-|--|-|--||-|-|--||-  27 [E]  COG2066 Glutaminase
 3  6 11 21 --------------|----|-------|||||-||||-  26 [I]  COG2067 Long-chain fatty acid transport protein
 6  9 12 18 |------||||-------|---|-|---|---|--||-  20 [R]  COG2068 Uncharacterized MobA-related protein
 1  5  5  5 |||---||------------------------------   6 [C]  COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein)
10 14 18 30 ------|----|--|||-||--||||-|-|--|||||-  53 [R]  COG2070 Dioxygenases related to 2-nitropropane dioxygenase
 5  8 12 22 ------------|------|--||||-||-----||||  26 [R]  COG2071 Predicted glutamine amidotransferases
 6  9 10 16 -----------||----||---|-|--|----|--||-  50 [P]  COG2072 Predicted flavoprotein involved in K+ transport
 6 15 17 21 ||-||-||||------||-|---||--||---|---|-  25 [H]  COG2073 Cobalamin biosynthesis protein CbiG
 2  6  6  8 ||--||-|----------|-------------------  10 [G]  COG2074 2-phosphoglycerate kinase
 4 12 14 16 ||||||||||||||------------------------  21 [J]  COG2075 Ribosomal protein L24E
 6 11 15 27 --||------------|-|---||||-||-|--||||-  65 [P]  COG2076 Membrane transporters of cations and cationic drugs
 4  8 12 25 --------------|-------|||||||-|||-|---  26 [O]  COG2077 Peroxiredoxin
 6 14 16 18 |||||||||||||-||-------|--------------  19 [S]  COG2078 Uncharacterized conserved protein
 6  9 12 21 |---|---||||----------|-|--||---|---|-  29 [R]  COG2079 Uncharacterized protein involved in propionate catabolism
 6  8 12 19 --------|||-------|--||-|--||---|--||-  49 [C]  COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs
 3  7 12 24 ----------------||-----|||-||-|||--||-  31 [R]  COG2081 Predicted flavoproteins
 7 17 19 24 |||||-||||------||-|--|||--||---|---|-  28 [H]  COG2082 Precorrin isomerase
 1  5  5  6 ||---|||------------------------------   6 [S]  COG2083 Uncharacterized protein conserved in archaea
 8 15 23 36 |-|-|---|||---|-|||---||||-||-|||||||-  79 [I]  COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
 5 12 12 14 ||||--||--------|-----|--|---|--|---|-  18 [R]  COG2085 Predicted dinucleotide-binding enzymes
 9 15 21 33 ---||-|-|||||--|--||--|||--|||--||-||-  54 [C]  COG2086 Electron transfer flavoprotein, beta subunit
 6 10 12 21 ----------------||||--|||--||-|-|---|-  22 [H]  COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase
 4  5  5  8 ------|------------|-|-||-------------   9 [M]  COG2088 Uncharacterized protein, involved in the regulation of septum location
 5  9  9 11 -||----------------|-|-||--------|||--  13 [M]  COG2089 Sialic acid synthase
 2  7  9 10 ||-|-||||||---------------------------  10 [S]  COG2090 Uncharacterized protein conserved in archaea
 4  8 10 16 -----------||---||-----||---||-||-----  22 [H]  COG2091 Phosphopantetheinyl transferase
 3 11 13 15 |||||||||||||-------------------------  15 [J]  COG2092 Translation elongation factor EF-1beta
 2  9 11 13 |||||||||||---------------------------  13 [K]  COG2093 DNA-directed RNA polymerase, subunit E''
 8 10 11 18 ----------|--|----|-|||||--|--------||  19 [L]  COG2094 3-methyladenine DNA glycosylase
 9 17 25 37 -||-|||||||---|-|-|-||--|--||||||||||-  64 [U]  COG2095 Multiple antibiotic transporter
 7 12 16 26 ---||||-|||-------||--|-|--||---|--||-  29 [S]  COG2096 Uncharacterized conserved protein
 4 12 14 16 ||||||||||||||------------------------  17 [J]  COG2097 Ribosomal protein L31E
 1  7  7  8 |||||-||------------------------------   8 [S]  COG2098 Uncharacterized protein conserved in archaea
 6 11 12 16 ||--------------||-|--|||--||---|---|-  16 [H]  COG2099 Precorrin-6x reductase
 2  5  6  7 -|---||||-|---------------------------   7 [R]  COG2100 Predicted Fe-S oxidoreductase
 4 12 14 16 ||||||||||||||------------------------  28 [K]  COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB
 4 12 14 16 ||||||||||||||------------------------  21 [R]  COG2102 Predicted ATPases of PP-loop superfamily
 4  7 10 18 ----------------|||----|||--|-||----|-  20 [R]  COG2103 Predicted sugar phosphate isomerase
 8 18 23 34 |-|||||-------|-||||--|||--||||-|||||-  36 [H]  COG2104 Sulfur transfer protein involved in thiamine biosynthesis
 6 10 13 18 -||--|--||------|||-----|--||-|-|-----  18 [S]  COG2105 Uncharacterized conserved protein
 3  8 10 11 |--|-||||||||-------------------------  12 [S]  COG2106 Uncharacterized conserved protein
 7  8 10 14 ----|-|-|||---|---|-|---|---------|---  14 [R]  COG2107 Predicted periplasmic solute-binding protein
 3  8 10 11 -|||-||||||------------|--------------  11 [R]  COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme
 8 14 16 26 --||||--|------|||||--|----||-|-|---|-  30 [H]  COG2109 ATP:corrinoid adenosyltransferase
10 16 20 27 --|-||||||||--||--||--|-||-||---|---|-  33 [R]  COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1
 7 13 15 22 ||||-|---------||||---|-|--|--|-----||  45 [P]  COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit
 3  5  7  8 -|---||-|||---|-----------------------   8 [T]  COG2112 Predicted Ser/Thr protein kinase
 4  6  8 17 --|------------------|--||-||---|---|-  40 [E]  COG2113 ABC-type proline/glycine betaine transport systems, periplasmic components
 7 10 11 16 --|--------|||--||---||----|-------||- 102 [T]  COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)
 3  4  6 14 ---------------|--------||--|--|----|-  14 [G]  COG2115 Xylose isomerase
 5  6 10 19 -------|---|-------|---|||-||-||------  35 [P]  COG2116 Formate/nitrite family of transporters
 1  5  5  6 ||||-|--------------------------------   6 [J]  COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain
 3 11 13 15 |||||||||||||-------------------------  15 [R]  COG2118 DNA-binding protein
 5  9 10 11 ---|-------||---||----|----|--|-|--|--  16 [S]  COG2119 Predicted membrane protein
 8 12 12 22 --|--|-|-|-|||----|---|-|---|-------|-  39 [S]  COG2120 Uncharacterized proteins, LmbE homologs
 3  4  6 10 --------------|----|--------------||||  11 [S]  COG2121 Uncharacterized protein conserved in bacteria
 2  6  6  6 |||---||----------------------------|-   6 [S]  COG2122 Uncharacterized conserved protein
 4 10 12 14 |-|-||||||||||------------------------  17 [J]  COG2123 RNase PH-related exoribonuclease
 7 13 15 22 ---|-------||---|||---|||--|-|--|-|||-  98 [Q]  COG2124 Cytochrome P450
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG2125 Ribosomal protein S6E (S10)
 4 12 13 15 ||||||||-|||||------------------------  16 [J]  COG2126 Ribosomal protein L37E
 5  9 14 27 ----------------|||---||---||||-|||||-  32 [S]  COG2127 Uncharacterized conserved protein
 6 10 14 27 --|---|---------|-|---||||-||---||-||-  59 [S]  COG2128 Uncharacterized conserved protein
 4  9 11 12 |||--||||||---|---------------------|-  15 [R]  COG2129 Predicted phosphoesterases, related to the Icc protein
 5  8 10 14 ---|-------||---|-------|--||---|--||-  16 [R]  COG2130 Putative NADP-dependent oxidoreductases
 8 15 16 23 --|-||||---||--|--||-|-||||---|-------  25 [F]  COG2131 Deoxycytidylate deaminase
 8 12 17 29 ---|----|--||-|-|-----|-|--|||-||||||-  54 [Q]  COG2132 Putative multicopper oxidases
 7 10 13 20 --------|-------|||--||-|--|||--|--||-  30 [G]  COG2133 Glucose/sorbosone dehydrogenases
 2  3  3 10 ----------------------|-----|-----|---  10 [I]  COG2134 CDP-diacylglycerol pyrophosphatase
 6  7  8 17 ---|-------|----|-----|-|--||-------|-  28 [S]  COG2135 Uncharacterized conserved protein
 4 10 12 13 |||--|||||||||------------------------  16 [JA] COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain
 7 10 15 29 ---------------|--||-|||||-||-||||--|-  29 [R]  COG2137 Uncharacterized protein conserved in bacteria
 7 13 14 18 ||||--||||------|||---|-|-------|-----  26 [S]  COG2138 Uncharacterized conserved protein
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG2139 Ribosomal protein L21E
 4  8  8 11 --|--||----------|------|---|---|---|-  14 [GR] COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes
 7 15 19 33 ||||--||-|------|-|---|-||||||--|--||- 165 [C]  COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
 5  8 14 26 ----|-|---|-------|---|----||||-||-|||  26 [C]  COG2142 Succinate dehydrogenase, hydrophobic anchor subunit
 3  3  3  4 --------------||------------------|---   5 [O]  COG2143 Thioredoxin-related protein
 2  5  5  5 |||----|---------|--------------------   8 [R]  COG2144 Selenophosphate synthetase-related proteins
 5 11 13 23 --|--||----||---------||||--|--|--|-|-  24 [H]  COG2145 Hydroxyethylthiazole kinase, sugar kinase family
 8 13 17 27 --|||---||--|---|||---|-|--|||--|--||-  51 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG2147 Ribosomal protein L19E
 8 13 20 30 ---|-----------|||||--||||-||||||||||-  57 [M]  COG2148 Sugar transferases involved in lipopolysaccharide synthesis
 4  5  5 10 --------------|-||----|-----|---------  10 [S]  COG2149 Predicted membrane protein
 1  6  6  8 |-|||||-------------------------------  12 [R]  COG2150 Predicted regulator of amino acid metabolism, contains ACT domain
 7 14 19 32 |||-||-||||----|--|---|-||--||--|--||-  43 [R]  COG2151 Predicted metal-sulfur cluster biosynthetic enzyme
 6  7  7  8 --|--|----|---||--------|---|---------  12 [G]  COG2152 Predicted glycosylase
 5  6  9 14 ------------|----|----|-||-||-|-----|-  14 [R]  COG2153 Predicted acyltransferase
 7 11 15 20 ---|----||-||-|-||----|----|-||-|--||-  22 [H]  COG2154 Pterin-4a-carbinolamine dehydratase
 4  5  6  9 --|-----------------|--||-----------||  10 [S]  COG2155 Uncharacterized conserved protein
 6 11 13 22 ---||-----------|||---|||--||---|--||-  25 [P]  COG2156 K+-transporting ATPase, c chain
 4 10 12 13 |||--|||||||||------------------------  15 [J]  COG2157 Ribosomal protein L20A (L18A)
 2  6  6  6 |||---||---------------|--------------   6 [R]  COG2158 Uncharacterized protein containing a Zn-finger-like domain
 6  9 11 17 ---|-|-|-||------|----|||----------||-  30 [R]  COG2159 Predicted metal-dependent hydrolase of the TIM-barrel fold
 3  5  5 10 ---------------|-------||---|-------|-  11 [G]  COG2160 L-arabinose isomerase
 6  8 11 15 ---|-----------|||----|-||--|-|-----||  30 [D]  COG2161 Antitoxin of toxin-antitoxin stability system
 3  4  6 12 ----------------------|-|--||------||-  14 [Q]  COG2162 Arylamine N-acetyltransferase
 5 10 12 13 ||---|-|||||||---------||-------------  22 [J]  COG2163 Ribosomal protein L14E/L6E/L27E
 2  3  3  3 |-----|--------|----------------------   3 [S]  COG2164 Uncharacterized conserved protein
 8 13 19 30 --------------|||||||--|||-||||||-|||-  88 [NU] COG2165 Type II secretory pathway, pseudopilin PulG
 5  7 12 22 ----------------|||-|-|----|||||---||-  27 [R]  COG2166 SufE protein probably involved in Fe-S center assembly
 4 12 13 15 ||||||||-|||||------------------------  15 [J]  COG2167 Ribosomal protein L39E
 3  3  6 12 |--------------|-----------||-||------  12 [P]  COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur
 3  5 10 20 ----------------------|-||-||-|-|--|||  25 [F]  COG2169 Adenosine deaminase
 4  6  7 12 ---|------------||----|----||---|-----  12 [S]  COG2170 Uncharacterized conserved protein
 5  9 17 37 -------|-------|------||||-|||||||||||  38 [E]  COG2171 Tetrahydrodipicolinate N-succinyltransferase
 6  8  8 13 ---------------||||-|-|||-------------  28 [T]  COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase)
 3  5  6 10 ----------------||----|-----|------||-  10 [M]  COG2173 D-alanyl-D-alanine dipeptidase
 4  8 10 11 ||---|-|||||||------------------------  13 [J]  COG2174 Ribosomal protein L34E
 3  6  8 13 -----------||---------|----||-|-|---|-  24 [Q]  COG2175 Probable taurine catabolism dioxygenase
 3  5  6 14 ---------------|---|---||||-----------  14 [L]  COG2176 DNA polymerase III, alpha subunit (gram-positive type)
 6  9 15 31 ----------------|-||--||||-|||||-|-||-  32 [D]  COG2177 Cell division protein
 3  7  9 10 -||--||||||-|-------------------------  10 [J]  COG2178 Predicted RNA-binding protein of the translin family
 4  5  6 11 ---------------||||-----||------------  12 [R]  COG2179 Predicted hydrolase of the HAD superfamily
 5  7  9 15 ------|-|-|-----------|-|--||---|---|-  21 [C]  COG2180 Nitrate reductase delta subunit
 5  7  8 14 ------|-|-------------|-|--||---|---|-  22 [C]  COG2181 Nitrate reductase gamma subunit
 6  8 12 22 ----||--|||----|--|-----||--|-|-----|-  29 [G]  COG2182 Maltose-binding periplasmic proteins/domains
 8 13 19 33 -----------|||--|--|-|||||||||||||--|-  33 [K]  COG2183 Transcriptional accessory protein
 3  6  9 17 ----------------------|--|-|||-|-||-|-  17 [D]  COG2184 Protein involved in cell division
 7 12 14 24 ---||||--||-------||--|-|---|---|--||-  36 [I]  COG2185 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)
 4  7 12 26 ------------------|---|||--||-||||-||- 126 [K]  COG2186 Transcriptional regulators
 4  6  7  8 --------------|-||----|----|-------||-   8 [S]  COG2187 Uncharacterized protein conserved in bacteria
 5  9 13 28 ----------------|-|---|||||||-|-|--||- 121 [K]  COG2188 Transcriptional regulators
 5 10 13 17 ----|-|------------|--|-|||-||-|-||-|-  33 [L]  COG2189 Adenine specific DNA methylase Mod
 5  9 13 26 -------------------|-||||||||-|||--|--  58 [G]  COG2190 Phosphotransferase system IIA components
 2  6  6  8 |-|-|||-----------|-------------------  12 [C]  COG2191 Formylmethanofuran dehydrogenase subunit E
 4  8  8 10 -|---|-|---------||--------|----|---|-  14 [O]  COG2192 Predicted carbamoyl transferase, NodU family
 3  6 11 21 ----------------||----|----||||-||-||-  26 [P]  COG2193 Bacterioferritin (cytochrome b1)
 1  4  9 20 ---------------------------|||||-||-||  48 [R]  COG2194 Predicted membrane-associated, metal-dependent hydrolase
 6  9 13 23 --|---------------||-|-|||--|-||--|||-  39 [E]  COG2195 Di- and tripeptidases
 5  9 16 32 ----------------|||---||||-|||||||-||- 199 [TK] COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
 3  6  9 14 -----------||---||---------||-||----|-  52 [T]  COG2198 FOG: HPt domain
 8 12 16 29 --------------|||||--||||--||||-|--||- 359 [T]  COG2199 FOG: GGDEF domain
 7 11 16 29 --------------|-|||--||||--||||-|--||| 227 [T]  COG2200 FOG: EAL domain
 6 13 17 26 --||-||--------||----|-||--||||-|-|||-  39 [NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain
11 19 23 36 |-||--|-----|-|||||-|||||--||||-|-|||- 446 [T]  COG2202 FOG: PAS/PAC domain
 9 16 19 28 |-||--|-----|-|||||---|||--||-|-|--||- 172 [T]  COG2203 FOG: GAF domain
 6  9 16 29 --------------|----|||--|--|||||||||||  89 [T]  COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
 5 10 13 21 ----------------|||---|||--||-|-|-|||-  23 [T]  COG2205 Osmosensitive K+ channel histidine kinase
 7 10 11 13 --------------|||-|--|-||--|--|-|---|-  35 [T]  COG2206 HD-GYP domain
 6 11 18 33 ---------------|||-|--||||-||||||||||- 427 [K]  COG2207 AraC-type DNA-binding domain-containing proteins
 8 11 12 18 ---------------|||-||||||--|--|-----|-  33 [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit
 2  3  6  9 --------------------|------||-||-|----  10 [C]  COG2209 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE
 5  8  9 11 --|||-|-||----|----|----|-------------  22 [S]  COG2210 Uncharacterized conserved protein
 4  7  8 12 ----------------||-|---|||--|------|--  42 [G]  COG2211 Na+/melibiose symporter and related transporters
 6 10 12 18 |-||-|---------|--|---|-|--|--|-----||  23 [P]  COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit
 2  4  7 16 -----------------------||||-|-||------  20 [G]  COG2213 Phosphotransferase system, mannitol-specific IIBC component
 9 15 19 30 ---|-------|||-||||--|-|--|||||--||||- 100 [O]  COG2214 DnaJ-class molecular chaperone
 4  6  7 15 -|-----------------|-|------|--||---|-  17 [R]  COG2215 ABC-type uncharacterized transport system, permease component
 6 12 14 23 ---||-----------|||---|||--||---|-|||-  26 [P]  COG2216 High-affinity K+ transport system, ATPase chain B
13 25 33 54 |-|||||-|||||-|||||||||||||||-|||||||- 150 [P]  COG2217 Cation transport ATPase
 1  5  5  5 |||---||------------------------------  10 [C]  COG2218 Formylmethanofuran dehydrogenase subunit C
 4 12 14 16 ||||||||||||||------------------------  16 [L]  COG2219 Eukaryotic-type DNA primase, large subunit
10 22 30 45 ||||||||||||---|||||--||||-||||||-|-||  81 [R]  COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold
 4  8  8  8 |||---|||--------------|----|---------  14 [C]  COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits
 6 10 14 24 |----|-|-------|--||---|||-|||-----||-  33 [M]  COG2222 Predicted phosphosugar isomerases
 4  6  8 17 --------------|-------|-|--||---|--||-  33 [P]  COG2223 Nitrate/nitrite transporter
 6  9 12 22 ---------|-||-----|---|-|--||-|-|--||-  26 [C]  COG2224 Isocitrate lyase
 6  8 12 22 --------||-|------|---|-|--||-|-|--||-  26 [C]  COG2225 Malate synthase
12 18 26 45 --|-|---||-||-|||||||-|-|--|||||||||||  52 [H]  COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis
 4  8 15 24 -----------||---|||--------|||||||-|||  26 [H]  COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase
 6  9  9 11 ||-----|---||-|---|---|----------|----  12 [R]  COG2229 Predicted GTPase
 6  9 12 24 --|-----------|---|---||---||-|-|-|||-  59 [M]  COG2230 Cyclopropane fatty acid synthase and related methyltransferases
 6  9  9 13 |||-|----|----||--------|---------|---  13 [L]  COG2231 Uncharacterized protein related to Endonuclease III
 1  5  5  5 |||---||------------------------------   5 [R]  COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase
 8 11 16 29 -----|------|--|--||--||||-||-||||--|-  69 [F]  COG2233 Xanthine/uracil permeases
 7 15 18 24 |-||-|||---||-|-|-----|||--||||----|--  41 [R]  COG2234 Predicted aminopeptidases
 6  9 12 18 ---||----|-----------||-|||||-|-----|-  21 [E]  COG2235 Arginine deiminase
 7 13 16 22 --|||||-|||||---|----||---------|||---  30 [R]  COG2236 Predicted phosphoribosyltransferases
 2  7  9 11 -||||||-|||---------------------------  12 [S]  COG2237 Predicted membrane protein
 4 12 14 16 ||||||||||||||------------------------  18 [J]  COG2238 Ribosomal protein S19E (S16A)
 9 14 19 31 |--------------|||-||||||-|||||--|-|||  43 [P]  COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain)
 6  9 12 20 -----------||-----|--|||-|-||--|---||-  26 [H]  COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase
 7 17 19 25 |||||-||||------||-|--|||--||---|---|-  25 [H]  COG2241 Precorrin-6B methylase 1
 7 16 18 24 |||||-||||------||-|--|||--||-------|-  26 [H]  COG2242 Precorrin-6B methylase 2
 7 17 19 24 |||||-||||------||-|--|||--||---|---|-  26 [H]  COG2243 Precorrin-2 methylase
 9 19 26 42 ||||||||-|-----||-||--||||-|||||||-||- 113 [R]  COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
 3  4  5  6 -|---|--|-|----|----------------------   7 [S]  COG2245 Predicted membrane protein
 6 14 19 28 ---||||||||-----||----||||-||---|--||-  37 [S]  COG2246 Predicted membrane protein
 2  3  3  4 -|---|------------------|-------------   9 [M]  COG2247 Putative cell wall-binding domain
 2  5  7  8 -|---||||||---------------------------   8 [R]  COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)
 5 10 15 26 --|---------|------|---||-|||-|||||||-  56 [R]  COG2249 Putative NADPH-quinone reductase (modulator of drug activity B)
 3  6  8  9 -|---||||||----|----------------------  42 [S]  COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
 4  5  5  9 -----|---------|||----|---------------   9 [R]  COG2251 Predicted nuclease (RecB family)
10 18 24 40 -|-|-|------|--|||||-||||||||-|||||||-  69 [R]  COG2252 Permeases
 2  3  3  5 ---|-|----------------|---------------   9 [S]  COG2253 Uncharacterized conserved protein
 2  4  6  7 -|---||-|||---------------------------  11 [L]  COG2254 Predicted HD superfamily hydrolase, possibly a nuclease
 9 15 23 48 ---------------|||||||||||||||||||||||  49 [L]  COG2255 Holliday junction resolvasome, helicase subunit
 7 13 20 39 -----------||--|--||--|||||||||||||||-  40 [L]  COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
 4  7  7 10 ---------------|-----|-||--|------||--  11 [S]  COG2257 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB
 4  8 10 19 ------------------|---|||--||--||-|-|-  25 [S]  COG2258 Uncharacterized protein conserved in bacteria
 8 11 16 30 ---|-----|-||---|-|---|-|--||-||||-||-  67 [S]  COG2259 Predicted membrane protein
 3 11 13 15 |||||||||||||-------------------------  15 [J]  COG2260 Predicted Zn-ribbon RNA-binding protein
 5  7 10 23 ----------------|-|---|-||-||---|--||-  43 [S]  COG2261 Predicted membrane protein
11 19 28 46 -|||-|-||||---|||||||-||||-|||||||-||-  49 [R]  COG2262 GTPases
 3 10 12 14 |||||||||||--|------------------------  15 [J]  COG2263 Predicted RNA methylase
 7 12 19 35 --------------||||||---|||-||||||||||-  37 [J]  COG2264 Ribosomal protein L11 methylase
11 17 24 42 -----|-----||-|||||||-||||-||||||||||-  67 [J]  COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase
 2  9 11 13 |||||||||||---------------------------  13 [H]  COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase
 9 14 19 33 -----||----||--||-||--||||-||-|||--||-  54 [I]  COG2267 Lysophospholipase
 4  6  8 12 ----------------||----|-||-||-------|-  14 [S]  COG2268 Uncharacterized protein conserved in bacteria
 3  4  8 16 --------------|------|------||||---||-  16 [J]  COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II)
 5  7  8 16 -----------||-|-------|||----------||-  17 [R]  COG2270 Permeases of the major facilitator superfamily
 3  5  9 18 --------------------|---||-||-||--|--|  37 [G]  COG2271 Sugar phosphate permease
 5  8  8 11 ------------|-----|---|||---|---|--|--  15 [I]  COG2272 Carboxylesterase type B
 5  7  8 12 -----------||--|------|||----------||-  22 [G]  COG2273 Beta-glucanase/Beta-glucan synthetase
 3  8 14 24 ----------------||-----||||||||-||-||-  44 [V]  COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
 7  9 14 24 ---|-----||-------||--|--|-||-|||--||-  41 [G]  COG2301 Citrate lyase beta subunit
 4  5  6 11 ----------------||||----||------------  11 [S]  COG2302 Uncharacterized conserved protein, contains S4-like domain
 6 12 14 22 ||-|---|--------|-|---|-|--||---|-|||-  74 [E]  COG2303 Choline dehydrogenase and related flavoproteins
 9 12 15 21 --|---|--||-----||||-||-|--||-|-----|-  35 [R]  COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain
 4  4  4  7 -----|------------|---|-|-------------   7 [S]  COG2306 Uncharacterized conserved protein
 4  6  7 11 -----------------||---|----|----|--||-  18 [S]  COG2307 Uncharacterized protein conserved in bacteria
 5  7  8 12 ---------|-------||---|----|----|--||-  19 [S]  COG2308 Uncharacterized conserved protein
 7  9 10 16 ---|-|-|--|---|---|--|--||----------|-  24 [E]  COG2309 Leucyl aminopeptidase (aminopeptidase T)
 4  5  5  7 -----------------||----||---|---------  33 [T]  COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1
 5  6  7 12 ---|--------------|---|-|---||-----|--  20 [S]  COG2311 Predicted membrane protein
 5  5  6  8 ---|--------------|---|-|----------||-   9 [R]  COG2312 Erythromycin esterase homolog
 5  6  6 11 ------------|--|--|-----|---|-------|-  11 [Q]  COG2313 Uncharacterized enzyme involved in pigment biosynthesis
 7 10 11 14 -||-------------|||--||-||-|----|-----  24 [S]  COG2314 Predicted membrane protein
 5  7 10 18 ------------------||--|-||-||---|--||-  23 [S]  COG2315 Uncharacterized protein conserved in bacteria
 3  3  3  3 ------|--------|--|-------------------   3 [R]  COG2316 Predicted hydrolase (HD superfamily)
 6  8 12 15 ---|-|--|||-------||----|---|-|-----||  15 [E]  COG2317 Zn-dependent carboxypeptidase
 4  5  5  9 -----------------||-----|--|--------|-  18 [S]  COG2318 Uncharacterized protein conserved in bacteria
 8 11 12 15 --|--------|||-|||||----------|----||- 289 [R]  COG2319 FOG: WD40 repeat
 5  6  7 10 --||--------------|---|-|--|--|-------  10 [S]  COG2320 Uncharacterized conserved protein
 4  6  8 17 ------------------|---|--|-||--||---|-  19 [R]  COG2321 Predicted metalloprotease
 4  4  4  7 ---|----------|---|-----|-------------   8 [S]  COG2322 Predicted membrane protein
 5  7  8 13 ----------------|-||---|||--|-------|-  30 [S]  COG2323 Predicted membrane protein
 3  5  5  5 |--|------------|||-------------------   5 [S]  COG2324 Predicted membrane protein
 5  9 11 16 --|-------------|||---|----|--|-|-|||-  24 [S]  COG2326 Uncharacterized conserved protein
 6  8  8 12 |--------------||||----|----|-------|-  14 [S]  COG2327 Uncharacterized conserved protein
 6  9 10 20 ---||----||-------|---|-|--|----|---|-  34 [R]  COG2329 Conserved protein involved in polyketide biosynthesis related to monooxygenase
 4  4  4  6 ---------------|--|---|---------|-----   6 [S]  COG2331 Uncharacterized protein conserved in bacteria
 3  4 10 19 --|---------------|--------|||||---|||  20 [O]  COG2332 Cytochrome c-type biogenesis protein CcmE
 5  7 13 24 ---|------------|-|----|||-|||||||----  30 [R]  COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily)
 6  8 12 21 --|--------------|||----|--||-|-||-||-  33 [R]  COG2334 Putative homoserine kinase type II (protein kinase fold)
 6  8  9 12 --|--------||---|||---|------------||-  23 [M]  COG2335 Secreted and surface protein containing fasciclin-like repeats
 4  6  7 10 ----------------|-|-----|---|---||--|-  14 [T]  COG2336 Growth regulator
 5  8 10 19 ----------------|-|---|||---||---|--||  41 [T]  COG2337 Growth inhibitor
 5  6  7 12 ---|-|----------|-|---|-||------------  14 [S]  COG2339 Predicted membrane protein
10 12 13 19 ------|----|-|--|-||-||||--|-------||-  34 [S]  COG2340 Uncharacterized protein with SCP/PR1 domains
 5  6  6  6 -|-----|-------|--||------------|-----   9 [G]  COG2342 Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase
 4  6  6  8 ----------------|||---|---------|---|-  17 [S]  COG2343 Uncharacterized protein conserved in bacteria
 3  4  5 10 ---------------|--|----|||------------  11 [R]  COG2344 AT-rich DNA-binding protein
 6  7  8 12 ----|-----------|||---|-|---|-|-------  19 [K]  COG2345 Predicted transcriptional regulator
 5  7  8 16 -----------------||---|-|-------|-|||-  20 [R]  COG2346 Truncated hemoglobins
 4  4  5  7 --|---------------|--|--||------------  14 [V]  COG2348 Uncharacterized protein involved in methicillin resistance
 6 10 15 24 ----------------||||--|||--||-||||-||-  28 [S]  COG2350 Uncharacterized protein conserved in bacteria
 4  7  9 16 ------------|-----|-----|--||---|-|||-  17 [R]  COG2351 Transthyretin-like protein
 5  8 12 20 ----------------|||---|--|-||-||||-|--  20 [C]  COG2352 Phosphoenolpyruvate carboxylase
 5  8 13 26 ----|-------------|---|-|--||||-|||||-  39 [S]  COG2353 Uncharacterized conserved protein
 3  5  8 13 ------------------|---|----||-|--|-||-  13 [S]  COG2354 Uncharacterized protein conserved in bacteria
 7  9 12 18 -----|--|||-|-----|-|---|--|----|--||-  26 [E]  COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog
 3  3  5 10 ------------------|-----|--||-|-------  10 [L]  COG2356 Endonuclease I
 4  5  6 13 ------------------||--||||------------  21 [S]  COG2357 Uncharacterized protein conserved in bacteria
 6  8 11 13 ---|--|---|------||-----|--|--||----||  21 [R]  COG2358 TRAP-type uncharacterized transport system, periplasmic component
 3  4  4  5 ---------------|--|----||-------------   8 [S]  COG2359 Uncharacterized protein conserved in bacteria
 3  7 12 20 ----------------|||--------||||-|||||-  20 [O]  COG2360 Leu/Phe-tRNA-protein transferase
 4  6  7  7 -||--------------||--------------|-||-  17 [S]  COG2361 Uncharacterized conserved protein
 5  6  6  8 -----|----|-------|-----|-------|---|-   8 [E]  COG2362 D-aminopeptidase
 5  6 10 21 ------------|---|-|-----|--||-||---||-  21 [S]  COG2363 Uncharacterized small membrane protein
 4  5  5  7 ------------------|---|||------|------   9 [S]  COG2364 Predicted membrane protein
 5  8 11 12 -----------||-----|---|-||-||---|--||-  19 [T]  COG2365 Protein tyrosine/serine phosphatase
 5  9 12 13 ----|-|-|||-----|||--------|----|--||-  20 [R]  COG2366 Protein related to penicillin acylase
 6  8  9 16 ----------------||||--||||----------|-  24 [V]  COG2367 Beta-lactamase class A
 5  5  8 10 ------|-||--------|-----|--||--|------  15 [Q]  COG2368 Aromatic ring hydroxylase
 4  5  7  8 -|----------------|-----|---||-|-|----  11 [S]  COG2369 Uncharacterized protein, homolog of phage Mu protein gp30
 4  7  7  8 --------------|-|||--------|----|---|-   8 [O]  COG2370 Hydrogenase/urease accessory protein
 5 10 12 19 ----------------|||---|-|-|||--||-|-|-  21 [O]  COG2371 Urease accessory protein UreE
 4  6  6 13 ------------------|---|-|---|---|---|-  13 [R]  COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC
 5  7 12 19 ---------------||-||-------|||-||--|||  23 [R]  COG2373 Large extracellular alpha-helical protein
 6  7  8  8 ----------------|||--||--|-|--|-------   8 [R]  COG2374 Predicted extracellular nuclease
 3  5  7 13 ------------------|---|----||-|-|---|-  21 [P]  COG2375 Siderophore-interacting protein
 5  7  9 17 -----------||-----||----||--|--|----|-  45 [G]  COG2376 Dihydroxyacetone kinase
 4  7 13 22 -------|--------|||--------|||||||-||-  22 [O]  COG2377 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases
 5  9 14 24 ------------------||--|||--||||-|||||-  39 [K]  COG2378 Predicted transcriptional regulator
 5  8 10 15 ----||--|||----|--|--------|----|---|-  19 [G]  COG2379 Putative glycerate kinase
 3  3  3  3 --------------||--|-------------------   3 [S]  COG2380 Uncharacterized protein conserved in bacteria
 4  5  6 12 ------------------|---|||--||---------  17 [P]  COG2382 Enterochelin esterase and related enzymes
 3  4  4  5 -|---|----|-------|-------------------   5 [S]  COG2383 Uncharacterized conserved protein
 3  5  6 13 ------------------|----||||---|-------  13 [R]  COG2384 Predicted SAM-dependent methyltransferase
 4  6  6  7 ----------------||||---||-------------  13 [D]  COG2385 Sporulation protein and related proteins
 3  5 10 18 --|---|-----------|--------|||||---||-  19 [O]  COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component
 7  8 13 19 ------|---|-------||--|-||-||-||---||-  20 [R]  COG2388 Predicted acetyltransferase
 4  5  5  5 --|-----------|-|||-------------------   5 [R]  COG2389 Uncharacterized metal-binding protein
 3  6  9 21 ------------------|----|||--|-|||---|-  47 [K]  COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
 6 11 15 23 ---||--|||-----|--|-----|--||||-|-|-|-  48 [R]  COG2391 Predicted transporter component
 3  5  5  6 -----|||--|-----------------|---------   7 [R]  COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain
 5  8  8  8 ---|-||-|-----|-||----|---------------  13 [R]  COG2402 Predicted nucleic acid-binding protein, contains PIN domain
 3  5  6  7 |----|-||-|------|--------------------   8 [R]  COG2403 Predicted GTPase
 5  6  7  9 --||-----||--------|----|---------|---   9 [R]  COG2404 Predicted phosphohydrolase (DHH superfamily)
 3  4  4  4 ------|---|-----||--------------------   6 [R]  COG2405 Predicted nucleic acid-binding protein, contains PIN domain
 3  4  6  6 |-|-----|||----|----------------------   6 [R]  COG2406 Protein distantly related to bacterial ferritins
 5  6  8 13 -----|--|-|----|-------|-|--|--|------  15 [G]  COG2407 L-fucose isomerase and related proteins
 5  6  8 14 ----|---|||-------|---|||-------------  49 [R]  COG2409 Predicted drug exporters of the RND superfamily
 2  4  6  6 |-----|||||---------------------------   6 [S]  COG2410 Uncharacterized conserved protein
 2  4  5  6 -----||||-|---------------------------  10 [S]  COG2411 Uncharacterized conserved protein
 2  7  8 10 --||||||-||---------------------------  10 [S]  COG2412 Uncharacterized conserved protein
 2  4  5  6 -----|||-||---------------------------   7 [R]  COG2413 Predicted nucleotidyltransferase
 4  8  9 13 -||-|||-|-|------------|----|---------  33 [C]  COG2414 Aldehyde:ferredoxin oxidoreductase
 2  4  6  7 -----||||||---------------------------   7 [S]  COG2419 Uncharacterized conserved protein
 7  7  9 11 -----|---||-|--||-------|----------||-  11 [C]  COG2421 Predicted acetamidase/formamidase
 6 14 17 21 |-|||-|||||||---------|-|--||---|---|-  37 [E]  COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog
 3  5  8 12 -||----||||-----------------|-|-------  15 [R]  COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain
 3  4  4  5 -----||---|-------------|-------------   5 [S]  COG2426 Predicted membrane protein
 3  4  6  9 ----|-|-|||-------------|-------------  21 [S]  COG2427 Uncharacterized conserved protein
 3  4  4  5 -----|-|--||--------------------------   5 [S]  COG2428 Uncharacterized conserved protein
 2  4  6  6 ||-|----|||---------------------------   7 [S]  COG2429 Uncharacterized conserved protein
 2  4  5  6 --|--||-|-|---------------------------   7 [S]  COG2430 Uncharacterized conserved protein
 4  5  9 16 -----|--|||--------|--------|-||-|----  16 [S]  COG2431 Predicted membrane protein
 2  7  9 10 |-||-||||||---------------------------  11 [S]  COG2433 Uncharacterized conserved protein
 5  6  8 13 ----|---|||----|---|--------|-------|-  21 [C]  COG2440 Ferredoxin-like protein
 2  3  4  5 -----||--||---------------------------   5 [C]  COG2441 Predicted butyrate kinase
 5  6  7  8 -----|---||-----||----|------|--------  23 [S]  COG2442 Uncharacterized conserved protein
 4 12 12 14 ||||||||--||||------------------------  14 [U]  COG2443 Preprotein translocase subunit Sss1
 4  8  8 10 |||--||-|-----|---------|-------------  24 [S]  COG2445 Uncharacterized conserved protein
 1  8  8 10 ||||||||------------------------------  10 [S]  COG2450 Uncharacterized conserved protein
 4  6  6  7 -----|-|--||||------------------------   9 [J]  COG2451 Ribosomal protein L35AE/L33A
 5  7  7  9 -|--||---|------|-----|------|--------  42 [L]  COG2452 Predicted site-specific integrase-resolvase
 7 10 13 17 -||--|--||-||---|-|---|----||-|-------  27 [T]  COG2453 Predicted protein-tyrosine phosphatase
 3  7  7  8 |||--|-|-|-------------|--------------   9 [S]  COG2454 Uncharacterized conserved protein
 1  3  3  4 ||---|--------------------------------   4 [S]  COG2456 Uncharacterized conserved protein
 2  7  7  8 |||--|||-|----------------------------   8 [S]  COG2457 Uncharacterized conserved protein
 4  6  7  8 -----||--------|---|---|||------------  10 [S]  COG2461 Uncharacterized conserved protein
 1  5  5  6 -|||-||-------------------------------   7 [S]  COG2469 Uncharacterized conserved protein
 6  9 12 23 ----------------|-||--|||||-|-|-||----  23 [S]  COG2501 Uncharacterized conserved protein
 4  5  6 12 -------------------|-|---||-|--|------  12 [E]  COG2502 Asparagine synthetase A
 3  5  6  8 ----------------|-------|||----|--|---   8 [R]  COG2503 Predicted secreted acid phosphatase
 4  6  7 14 ------------------|---||||-|--------|-  36 [TQ] COG2508 Regulator of polyketide synthase expression
 7 12 14 15 --|--|||||-----|-|-|---|||----|----|--  16 [R]  COG2509 Uncharacterized FAD-dependent dehydrogenases
 3  8  9 12 ||---|-|--------|----------||----|--|-  12 [S]  COG2510 Predicted membrane protein
 2  9 11 13 |||||||||||---------------------------  13 [J]  COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain)
 2  5  7  9 --|-|||-|||---------------------------  18 [S]  COG2512 Uncharacterized membrane-associated protein/domain
 6  8 15 25 ----|---|||-----|-----|-|--||||-||-||-  36 [G]  COG2513 PEP phosphonomutase and related enzymes
 5  5  7 14 --------|-|-------|---|-||----------|-  17 [R]  COG2514 Predicted ring-cleavage extradiol dioxygenase
 5  8 10 15 -----|------|--||-----------|-|-|-|||-  16 [E]  COG2515 1-aminocyclopropane-1-carboxylate deaminase
 5  6  6  7 --|--|---|----||-|--------------------   7 [R]  COG2516 Biotin synthase-related enzyme
 1  4  4  5 |----|||------------------------------   5 [R]  COG2517 Predicted RNA-binding protein containing a C-terminal EMAP domain
 5 14 21 32 ||||-||||||-|--|-----------||||-|||||-  46 [O]  COG2518 Protein-L-isoaspartate carboxylmethyltransferase
 6 13 15 20 ||-||||||||||-||------|---------------  20 [J]  COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases
 4 12 14 16 ||||||||||||||------------------------  32 [R]  COG2520 Predicted methyltransferase
 3  5  6  7 -|---|-||-|------------------|--------   7 [R]  COG2521 Predicted archaeal methyltransferase
 2  5  7  8 --||-||-|||---------------------------  13 [R]  COG2522 Predicted transcriptional regulator
 2  6  8  8 ||||--|-|||---------------------------   8 [K]  COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains
 3  7  8 10 ----------------||------|--|----|-|-||  12 [V]  COG2602 Beta-lactamase class D
 2  3  4  7 -|-------------------------||-----|---   8 [R]  COG2603 Predicted ATPase
 3  3  3  5 ---------------------|-|----------|---  17 [S]  COG2604 Uncharacterized protein conserved in bacteria
 5  5  5  7 ----|------------|----||----------|---   9 [R]  COG2605 Predicted kinase related to galactokinase and mevalonate kinase
 6  8 15 30 --------|-|-----|--|--|-||-||-||||-||-  46 [S]  COG2606 Uncharacterized conserved protein
 4  8 10 14 --------------|-||-----|---|----|||||-  14 [R]  COG2607 Predicted ATPase (AAA+ superfamily)
11 21 26 36 --|||-|--||||-||||||--|||||||--||||-|-  59 [P]  COG2608 Copper chaperone
 3  5 11 21 ------------------|---|----|||||||-||-  21 [C]  COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component
 5  7 12 20 --|----------------|--||||-||-||||----  51 [GE] COG2610 H+/gluconate symporter and related permeases
 4  6  7  7 -|------------|--------|---|--|-|-|---   9 [P]  COG2703 Hemerythrin
 2  3  5 12 -----------------------|----|-||--|---  21 [R]  COG2704 Anaerobic C4-dicarboxylate transporter
 3  5  7 15 ------------|----------|||-||---|-----  16 [G]  COG2706 3-carboxymuconate cyclase
 2  4  5 13 -----------------------||---|--|-|----  13 [S]  COG2707 Predicted membrane protein
 5  9  9 10 |||----|--------||-|---|------------|-  44 [C]  COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains
 3  5  5  6 -----------------|-----||--|----|-----   6 [R]  COG2715 Uncharacterized membrane protein, required for spore maturation in B.subtilis.
 1  2  5  9 ---------------------------||||----|--  11 [E]  COG2716 Glycine cleavage system regulatory protein
 5  8 11 17 ----------------|-|--|-|---||--||-|||-  18 [S]  COG2717 Predicted membrane protein
 3  5  7 13 ---|-------------------||--||-|-----|-  13 [S]  COG2718 Uncharacterized conserved protein
 3  5  7 13 ---|-------------------||--||-|-----|-  13 [S]  COG2719 Uncharacterized conserved protein
 4  5  5  6 ------------------|---|||--|----------   8 [V]  COG2720 Uncharacterized vancomycin resistance protein
 4  8  9 17 ----|----|-------------||---|---|-|||-  28 [G]  COG2721 Altronate dehydratase
 5  8 12 24 ----||--||------------||||--|-|----||-  65 [G]  COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase
 6  9  9 11 -----|-----||--||------||----|--|-----  24 [G]  COG2730 Endoglucanase
 3  6  8 14 -------------------|---|-||-|-||--|---  29 [G]  COG2731 Beta-galactosidase, beta subunit
 2  4  4  8 -----------------------||---|----|----   8 [K]  COG2732 Barstar, RNAse (barnase) inhibitor
 3  4  5 10 ----------------------||----||------|-  11 [S]  COG2733 Predicted membrane protein
 3  4  4  7 ---------------|--|----||-------------   8 [R]  COG2738 Predicted Zn-dependent protease
 2  4  5 12 -------------------|---||||-----------  12 [S]  COG2739 Uncharacterized protein conserved in bacteria
 6  9 11 25 ----------------|-||--|||||-------|||-  25 [K]  COG2740 Predicted nucleic-acid-binding protein implicated in transcription termination
 4  6  6  8 ----------------|-|----||---------|-|-  11 [V]  COG2746 Aminoglycoside N3'-acetyltransferase
 4  6  8 13 --------------||-------||--||-|-|-----  13 [KNU] COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor)
 6 12 18 32 ---------|-||---||----||||-||-|||||||-  63 [E]  COG2755 Lysophospholipase L1 and related esterases
 6 11 12 18 ----|------||--|---|---||||---|--|--|-  21 [F]  COG2759 Formyltetrahydrofolate synthetase
 6  9 11 17 ---|-----|--------|---|||----||-|--||-  20 [Q]  COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis
 4  7 10 18 ----------------|-----||||-||---|--||-  32 [S]  COG2764 Uncharacterized protein conserved in bacteria
 3  5  7 13 ---|-------------------||--||-|-----|-  14 [T]  COG2766 Putative Ser protein kinase
 3  5  5  5 |-|---|--------|-------|--------------   6 [R]  COG2768 Uncharacterized Fe-S center protein
 6 10 11 13 --|---|-------|-|||-----|--|--|-|---|-  23 [T]  COG2770 FOG: HAMP domain
 7 11 15 28 -------||-------|||---||||-||-|-|--||- 155 [K]  COG2771 DNA-binding HTH domain-containing proteins
 8 15 21 37 --|-|-|----||---||||--|-|||||-||||-||- 415 [L]  COG2801 Transposase and inactivated derivatives
 5  8 10 14 ------------|---|||---|----|--|-|--||-  14 [R]  COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease
 8 13 20 32 --------------|||||||--|||-||||||||||-  48 [NU] COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB
 7  9 13 18 --------------||||||---|---||||-||----  23 [NU] COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT
 4  8 10 14 ------------------|---||||-||---|-|-|-  20 [P]  COG2807 Cyanate permease
 4  6  8  9 -----------|------|-----|--|-|--|--||-  10 [K]  COG2808 Transcriptional regulator
 3  3  3  4 -----|----|-------|-------------------   4 [V]  COG2810 Predicted type IV restriction endonuclease
 2  8  8 10 |||||||-----------|-------------------  10 [C]  COG2811 Archaeal/vacuolar-type H+-ATPase subunit H
10 16 24 50 --------------||||||||||||||||||||||||  55 [L]  COG2812 DNA polymerase III, gamma/tau subunits
 6  9 14 29 -|---|-|-|-----|--|-----||-||-||---||-  37 [J]  COG2813 16S RNA G1207 methylase RsmC
 3  6 10 24 ----------------------|-||-|||-||-|-|-  69 [G]  COG2814 Arabinose efflux permease
 6  7  8 17 ---------------|--||-|||||------------  18 [S]  COG2815 Uncharacterized protein conserved in bacteria
 6  8 12 22 --|--------||-----|---||---||-||---||-  23 [L]  COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding
 3  5 11 27 ----------------------|-||-||-||||-||-  30 [L]  COG2818 3-methyladenine DNA glycosylase
 3  7 10 12 ------------------|----|||-||----||||-  13 [R]  COG2819 Predicted hydrolase of the alpha/beta superfamily
 6  6 10 16 ---|----|||----------||--|--|-||------  20 [F]  COG2820 Uridine phosphorylase
 2  5 10 20 ----------------||---------||-||||-||-  21 [M]  COG2821 Membrane-bound lytic murein transglycosylase
 2  3  3  9 ------------------------|---|----|----   9 [P]  COG2822 Predicted periplasmic lipoprotein involved in iron transport
 3  5 10 17 ------------------|----|---||-||||--||  28 [R]  COG2823 Predicted periplasmic or secreted lipoprotein
 3  6 12 25 ----------------------|-||-||-|||||||-  25 [P]  COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism
 6  8 13 22 --------------||--|-||-----||-||||-|-|  23 [M]  COG2825 Outer membrane protein
 3  6  9 16 ----------------------|-|||-|---||-||-  66 [L]  COG2826 Transposase and inactivated derivatives, IS30 family
 4  6 10 22 ---|---------------|----||-||-|--|-||-  30 [L]  COG2827 Predicted endonuclease containing a URI domain
 2  4  8 13 ------------------------|--||||-||--|-  13 [S]  COG2828 Uncharacterized protein conserved in bacteria
 1  3  4 11 ----------------------------|--|-||---  11 [M]  COG2829 Outer membrane phospholipase A
 1  3  3  5 -------------------------------|-||---   5 [S]  COG2830 Uncharacterized protein conserved in bacteria
 3  7 11 15 ----------------||-|-------|||-|||||--  42 [U]  COG2831 Hemolysin activation/secretion protein
 4  6 10 17 ------------------||----||-||-||-|--|-  17 [S]  COG2832 Uncharacterized protein conserved in bacteria
 1  4  5  9 -------------------------------||||-|-  10 [S]  COG2833 Uncharacterized protein conserved in bacteria
 6 13 20 34 -|||--|-------|---|--|-||--|||||||||||  44 [M]  COG2834 Outer membrane lipoprotein-sorting protein
 4  7 15 25 --||----|||-----------|----|||||||-||-  25 [S]  COG2835 Uncharacterized conserved protein
 4  6  8 11 ---|------------|------|---|--|-|||---  11 [S]  COG2836 Uncharacterized conserved protein
 5  7 11 20 ----------------|-|---|-|--||-||||--|-  26 [P]  COG2837 Predicted iron-dependent peroxidase
 2  4  6 10 ----------------------|----|-||--||---  10 [C]  COG2838 Monomeric isocitrate dehydrogenase
 4  4  4  7 ----------------|-|-----|--------|----   7 [S]  COG2839 Uncharacterized protein conserved in bacteria
 2  4 10 20 ---------------------|-----|||||||-||-  25 [S]  COG2840 Uncharacterized protein conserved in bacteria
 1  4  6 11 ---------------------------||--|-||-|-  11 [S]  COG2841 Uncharacterized protein conserved in bacteria
 4  5  6  8 ----------------|-|-----|---|--|-|----   9 [R]  COG2842 Uncharacterized ATPase, putative transposase
 5  6  8 13 --|---------------|---|-||-------|-||-  15 [M]  COG2843 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
 2  4  9 20 ----------------------|----||-||||-||-  20 [O]  COG2844 UTP:GlnB (protein PII) uridylyltransferase
 2  4  4  8 ---------------------|-----------||-|-   8 [S]  COG2845 Uncharacterized protein conserved in bacteria
 2  5  7 12 -----------------------||---|--|||--|-  12 [D]  COG2846 Regulator of cell morphogenesis and NO signaling
 5  8 13 18 --------|-----|---|---|----|--||||||||  18 [S]  COG2847 Uncharacterized protein conserved in bacteria
 5  8 11 13 -||----||||-----------||||-------|----  14 [S]  COG2848 Uncharacterized conserved protein
 4  6  7 10 -------------------||---|--||----||---  38 [S]  COG2849 Uncharacterized protein conserved in bacteria
 2  3  7 13 ------------------------|--|||-|||----  14 [S]  COG2850 Uncharacterized conserved protein
 3  5  7 10 ----------------------|-||-|-|---||---  12 [C]  COG2851 H+/citrate symporter
 4  6  8  9 ----------------|-|-----|---|--|-|-||-  12 [S]  COG2852 Uncharacterized protein conserved in bacteria
 2  5 11 18 -------------------|-------|||||||||-|  20 [M]  COG2853 Surface lipoprotein
 1  4 10 17 ---------------------------|||||||||-|  17 [Q]  COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component
 5  8 13 25 ------|------------|--|-||-||--||||||-  26 [S]  COG2855 Predicted membrane protein
 7 10 12 16 ----------------|-||-|||||---|--||--|-  19 [E]  COG2856 Predicted Zn peptidase
 4  8 13 21 -----------||-|---------|--|-||-||||||  24 [C]  COG2857 Cytochrome c1
 3  4  5  6 -----------------|---|------|-|---|---   8 [S]  COG2859 Uncharacterized protein conserved in bacteria
 6  9 15 25 ---|----||--------|---|-||-||-|||-|||-  32 [S]  COG2860 Predicted membrane protein
 3  5  8 14 ---------------------|--|--||--|--|||-  14 [S]  COG2861 Uncharacterized protein conserved in bacteria
 4  7 11 18 --|-----------|---|--------||-|||-|||-  19 [S]  COG2862 Predicted membrane protein
 2  5  9 12 ------------------|--------||-|||||-|-  21 [C]  COG2863 Cytochrome c553
 3  7 10 15 --|---|-------|------------||-|||-|-|-  20 [C]  COG2864 Cytochrome b subunit of formate dehydrogenase
 6  7  7  7 --|--|------------||--|---|-------|---  13 [K]  COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen
 5  8 10 16 --|--------||----|------|--||---||-|--  19 [E]  COG2866 Predicted carboxypeptidase
 2  5 12 21 -----------||--------------|||||||-|||  21 [I]  COG2867 Oligoketide cyclase/lipid transport protein
 3  5  6 14 -------------------|-|-||||-----------  14 [J]  COG2868 Predicted ribosomal protein
 2  3  6  9 --------------------|------||-||-|----   9 [C]  COG2869 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC
 4  7 11 20 -|------------|----|-------||--||||||-  25 [M]  COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase
 2  3  6  9 --------------------|------||-||-|----   9 [C]  COG2871 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF
 8 13 16 21 --|-||--||||---|--||---||--|--|-|---|-  28 [R]  COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain
 7 13 15 21 --||-------||--|--|---||||-|---||-|-|-  25 [E]  COG2873 O-acetylhomoserine sulfhydrylase
 2  7  8 10 -||||||--||---------------------------  11 [NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella
 7 17 19 24 |||||-||||------||-|--|||--||---|---|-  24 [H]  COG2875 Precorrin-4 methylase
 9 12 15 20 ----||--|||----||||||--|||-------|----  22 [E]  COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase
 4  7 14 27 --------------|----||------|||||||||||  27 [M]  COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase
 4  5 10 17 --|------------|---|-------|||||||----  17 [C]  COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB
 1  3  5 10 ---------------------------||---|||---  12 [S]  COG2879 Uncharacterized small protein
 2  4  4  4 -|---||---|---------------------------  18 [S]  COG2880 Uncharacterized protein conserved in archaea
 1  5  5  5 ||||--|-------------------------------  12 [S]  COG2881 Uncharacterized protein conserved in archaea
 4  6  8 14 ---------------|-----|-||--||-|-|-----  14 [NUO] COG2882 Flagellar biosynthesis chaperone
 5  8 14 30 ----------------|-|---||||-|||||-|-||-  30 [D]  COG2884 Predicted ATPase involved in cell division
 7 10 17 33 --------------|-|--||||----|||||||||||  99 [M]  COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins
 3  6  7  8 ---|-||-|-|-----||--------------------  10 [S]  COG2886 Uncharacterized small protein
 5  7  9 18 --|-------|----------||---------|-||||  24 [L]  COG2887 RecB family exonuclease
 2  9 11 13 |||||||||||---------------------------  13 [J]  COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation
14 28 38 66 ||||||||||||||||||||||||||||||||||||||  89 [J]  COG2890 Methylase of polypeptide chain release factors
 4  5 10 19 ----------------|----|--||-||||||-----  19 [M]  COG2891 Cell shape-determining protein
 2  7  7  8 |||--|||--|---------------------------   8 [S]  COG2892 Uncharacterized protein conserved in archaea
 3  6 11 22 -------------------|---|||--||-|||-||-  43 [G]  COG2893 Phosphotransferase system, mannose/fructose-specific component IIA
 7 12 16 28 --------------||||||---||--||||-|||-|-  28 [D]  COG2894 Septum formation inhibitor-activating ATPase
 3  5 10 21 ----------------------||---||||-||-||-  24 [P]  COG2895 GTPases - Sulfate adenylate transferase subunit 1
 8 20 26 43 |||||||||||---|-|||---|||--||-|||-|||-  50 [H]  COG2896 Molybdenum cofactor biosynthesis enzyme
 9 13 18 28 |--|----|||||-|-|-|---|-|--||-|-|--||-  49 [P]  COG2897 Rhodanese-related sulfurtransferase
 4  6  9 17 --|-------------------|-||-|-|--|--||-  19 [S]  COG2898 Uncharacterized conserved protein
 4  5  5  9 ------------------|---|--|---|------|-   9 [S]  COG2899 Uncharacterized protein conserved in bacteria
 1  3  7 16 ---------------------------|||||-|--|-  16 [S]  COG2900 Uncharacterized protein conserved in bacteria
 1  2  7 14 ---------------------------|||||||----  14 [KL] COG2901 Factor for inversion stimulation Fis, transcriptional activator
 3  5  9 15 -----------||---------|----|-||----|||  15 [E]  COG2902 NAD-specific glutamate dehydrogenase
 1  3  7 13 ---------------------------||||||----|  14 [S]  COG2904 Uncharacterized protein conserved in bacteria
 5  5  6  6 ------|-------|-------|-|--|--|-------   8 [T]  COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains
 3  5  9 13 -----------------|----|----||||-||-|--  13 [P]  COG2906 Bacterioferritin-associated ferredoxin
 2  4  5  8 ----------------------|-------|--|-||-   9 [R]  COG2907 Predicted NAD/FAD-binding protein
 2  5 11 21 ---------------|-----------||||||||||-  23 [S]  COG2908 Uncharacterized protein conserved in bacteria
 3  3  5 10 ----------------------||---||-|-------  13 [K]  COG2909 ATP-dependent transcriptional regulator
 2  5  7 11 ------------------------||-|--|-|-|-|-  11 [R]  COG2910 Putative NADH-flavin reductase
 1  3  9 19 ---------------------------|||||||-||-  19 [S]  COG2911 Uncharacterized protein conserved in bacteria
 3  5  9 16 ----------------|---|------||||||--|--  16 [S]  COG2912 Uncharacterized conserved protein
 1  3 10 21 ---------------------------|||||||-|||  24 [J]  COG2913 Small protein A (tmRNA-binding)
 1  2  7 14 ---------------------------|||||||----  14 [S]  COG2914 Uncharacterized protein conserved in bacteria
 1  1  5 11 ---------------------------|||||------  11 [R]  COG2915 Uncharacterized protein involved in purine metabolism
 1  2  5 11 ----------------------------|||||-----  23 [R]  COG2916 DNA-binding protein H-NS
 1  3  9 19 ---------------------------||-||||-|||  19 [D]  COG2917 Intracellular septation protein A
 2  3  6 11 -----------------------||--||-||------  11 [H]  COG2918 Gamma-glutamylcysteine synthetase
 4  6 14 34 ---------------------||-||-|||||||-|||  34 [D]  COG2919 Septum formation initiator
 3  3  6 12 ------|-|------------------||-||------  12 [P]  COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit
 1  2  7 14 ---------------------------|||||||----  14 [S]  COG2921 Uncharacterized conserved protein
 1  2  4 10 ----------------------------|||--|----  10 [S]  COG2922 Uncharacterized protein conserved in bacteria
 3  4  7 13 |-|------------|-----------||-||------  13 [P]  COG2923 Uncharacterized protein involved in the oxidation of intracellular sulfur
 1  2  7 14 ---------------------------|||||||----  14 [CO] COG2924 Fe-S cluster protector protein
 1  2  6 12 ---------------------------||||||-----  12 [L]  COG2925 Exonuclease I
 2  2  4 10 -------------------|--------|-||------  10 [S]  COG2926 Uncharacterized protein conserved in bacteria
 1  3 10 20 ---------------------------|||||||-|||  20 [L]  COG2927 DNA polymerase III, chi subunit
 6  8 10 14 ---|------------|--||---|--|-|--||--|-  14 [S]  COG2928 Uncharacterized conserved protein
 2  5  8 10 ----------------||----------|||--|-||-  13 [S]  COG2929 Uncharacterized protein conserved in bacteria
 3  5  5  5 -----------||--|-------------|--|-----   7 [S]  COG2930 Uncharacterized conserved protein
 3  6 11 14 --------------|-||---------||||-||-||-  70 [Q]  COG2931 RTX toxins and related Ca2+-binding proteins
 3  5 10 17 -------------------|----||-|||-|-|-||-  33 [K]  COG2932 Predicted transcriptional regulator
 1  1  4  9 ---------------------------|||-|------   9 [R]  COG2933 Predicted SAM-dependent methyltransferase
 2  6  9 12 -----------||--------------|-||-|-|||-  12 [O]  COG2935 Putative arginyl-tRNA:protein arginylyltransferase
 4  5  7 10 -----------------|----|-||---|-----||-  16 [R]  COG2936 Predicted acyl esterases
 2  2  6 13 ----------------------|----|||||------  15 [I]  COG2937 Glycerol-3-phosphate O-acyltransferase
 2  5 12 22 -----------||--------------|||||||-|||  22 [S]  COG2938 Uncharacterized conserved protein
 3  6  6  6 -----------||-----|----------|--|--|--  10 [E]  COG2939 Carboxypeptidase C (cathepsin A)
 5  8  8  9 --|--------|||------|--------|--|---|-  22 [R]  COG2940 Proteins containing SET domain
 2  5  7  8 -----------||--------------|-|--|--|-|   8 [H]  COG2941 Ubiquinone biosynthesis protein COQ7
 2  5  7 13 ----------------||----------||--|--||-  16 [G]  COG2942 N-acyl-D-glucosamine 2-epimerase
 1  3  6  9 ---------------------------||||-|--|--   9 [M]  COG2943 Membrane glycosyltransferase
 2  4  8 13 ----------------|-----------|||-||--||  20 [K]  COG2944 Predicted transcriptional regulator
 2  5  9 14 ---|--|--------------------|-|--||-|||  14 [R]  COG2945 Predicted hydrolase of the alpha/beta superfamily
 2  3  4  5 ------------------------|----||--|----  10 [L]  COG2946 Putative phage replication protein RstA
 4  7  8 11 ------------|---|||--------|-|--|---|-  11 [S]  COG2947 Uncharacterized conserved protein
 1  4  6 11 -----------------------------|--|-||||  23 [U]  COG2948 Type IV secretory pathway, VirB10 components
 3  3  5 10 ----------------|-|---------|-||------  14 [S]  COG2949 Uncharacterized membrane protein
 2  4 10 20 ----------------------|----|||||||-||-  40 [M]  COG2951 Membrane-bound lytic murein transglycosylase B
 2  2  2  4 --------------|-------------------|---   4 [S]  COG2952 Uncharacterized protein conserved in bacteria
 2  5  5  8 ----------------||-----------|---|--|-  10 [S]  COG2954 Uncharacterized protein conserved in bacteria
 1  2  6 12 ----------------------------||||||----  12 [G]  COG2956 Predicted N-acetylglucosaminyl transferase
 3  5  7 10 ------------------|------|-|||----||--  10 [E]  COG2957 Peptidylarginine deiminase and related enzymes
 1  3  4  6 ---------------------------|-|--|-|---   6 [S]  COG2958 Uncharacterized protein conserved in bacteria
 1  2  6 12 ---------------------------||-||||----  12 [H]  COG2959 Uncharacterized enzyme of heme biosynthesis
 1  3  7 15 ---------------------------||||-||--|-  15 [S]  COG2960 Uncharacterized protein conserved in bacteria
 1  3 10 19 ---------------------------|||||||-|||  19 [R]  COG2961 Protein involved in catabolism of external DNA
 3  5  9 20 ----------------------|-|--||-|||--||-  24 [R]  COG2962 Predicted permeases
 6  8 13 26 ----|-------------||--|-||-||-|||--||- 233 [L]  COG2963 Transposase and inactivated derivatives
 3  6  9 14 -------------------|-----|-||-|||-|-|-  17 [S]  COG2964 Uncharacterized protein conserved in bacteria
 1  2  5 11 ----------------------------|-||||----  11 [L]  COG2965 Primosomal replication protein N
 6  9 13 22 |----------||------|--||||--||||--|---  25 [S]  COG2966 Uncharacterized conserved protein
 2  4  8 15 ------------------|--------||||-|--||-  15 [P]  COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport
 5  8 11 19 --||------------||----|-|---|||----||-  19 [S]  COG2968 Uncharacterized conserved protein
 1  2  7 13 ---------------------------|||||||----  13 [R]  COG2969 Stringent starvation protein B
 7  8  8 11 ----|----|-----||-|----|------|-----|-  14 [G]  COG2971 Predicted N-acetylglucosamine kinase
 3  5  8 12 -------------------|---|||-|-||-|-----  33 [T]  COG2972 Predicted signal transduction protein with a C-terminal ATPase domain
 2  2  5 10 --------------------|-------||||------  10 [K]  COG2973 Trp operon repressor
 1  2  7 13 ---------------------------|||||||----  13 [L]  COG2974 DNA recombination-dependent growth factor C
 1  2  6 11 ---------------------------||-||||----  12 [S]  COG2975 Uncharacterized protein conserved in bacteria
 1  2  7 14 ---------------------------|||||||----  14 [S]  COG2976 Uncharacterized protein conserved in bacteria
 2  3  5 14 ----------------------|----||-|-----|-  14 [Q]  COG2977 Phosphopantetheinyl transferase component of siderophore synthetase
 4  6  8 13 -------------------|--|-|---|-||-|-|--  19 [H]  COG2978 Putative p-aminobenzoyl-glutamate transporter
 1  3  6 13 ---------------------------||-||-|--|-  13 [S]  COG2979 Uncharacterized protein conserved in bacteria
 1  2  7 13 ---------------------------|||||||----  13 [M]  COG2980 Rare lipoprotein B
 2  3  6 14 -----------------|---------||-||----|-  14 [E]  COG2981 Uncharacterized protein involved in cysteine biosynthesis
 1  3  7 15 ---------------------------||-|-||--||  23 [M]  COG2982 Uncharacterized protein involved in outer membrane biogenesis
 2  3  7 15 -|-------------------------||-||---||-  15 [S]  COG2983 Uncharacterized conserved protein
 6  8 10 16 --------------|----||-|--|-|--|-|---||  17 [R]  COG2984 ABC-type uncharacterized transport system, periplasmic component
 4  4  6 11 ---|---------------|--|-----|-||------  17 [R]  COG2985 Predicted permease
 5  8 12 19 ---||-------------||----||-||-|-|--||-  29 [E]  COG2986 Histidine ammonia-lyase
 5  8 12 18 ---||-------------||----||-||-|-|--||-  19 [E]  COG2987 Urocanate hydratase
 2  3  5  9 ----------------||---------||-|-------   9 [E]  COG2988 Succinylglutamate desuccinylase
 1  2  5 13 ----------------------------|-||---||-  17 [S]  COG2989 Uncharacterized protein conserved in bacteria
 1  4  6 12 ----------------------------|-||-||-|-  15 [S]  COG2990 Uncharacterized protein conserved in bacteria
 1  2  5  7 ---------------------------||-||-|----   8 [S]  COG2991 Uncharacterized protein conserved in bacteria
 2  3  4  7 -------------------|--------|-|---|---   7 [R]  COG2992 Uncharacterized FlgJ-related protein
 1  4  7 13 ---------------------------|--|-|||||-  18 [C]  COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit
 2  4  5  5 -----------------|------------|-||--|-   6 [O]  COG2994 ACP:hemolysin acyltransferase (hemolysin-activating protein)
 1  2  5 11 ----------------------------|-||||----  18 [S]  COG2995 Uncharacterized paraquat-inducible protein A
 3  4  6 11 -------------------|---|||-|--|-------  11 [S]  COG2996 Uncharacterized protein conserved in bacteria
 3  5  5  5 |-------|---------------------|-|-|---   5 [H]  COG2998 ABC-type tungstate transport system, permease component
 1  2  4  8 ----------------------------|-||-|----   8 [O]  COG2999 Glutaredoxin 2
 4  8 10 13 -----------||---||----|----|--|-|--||-  32 [I]  COG3000 Sterol desaturase
 4  5  7 11 ----------------||----|-|---|-||------  11 [G]  COG3001 Fructosamine-3-kinase
 3  3  3  4 --------------|---------|-----|-------   4 [S]  COG3002 Uncharacterized protein conserved in bacteria
 1  3  7 16 ----------------------------|-||--||||  18 [P]  COG3004 Na+/H+ antiporter
 1  3  6 12 ---------------------------||-||--|-|-  26 [C]  COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit
 1  1  3  8 ----------------------------|-||------   8 [D]  COG3006 Uncharacterized protein involved in chromosome partitioning
 2  2  5  5 -----------------------|---||||-------   7 [S]  COG3007 Uncharacterized paraquat-inducible protein B
 1  2  6 12 ---------------------------||-||||----  19 [R]  COG3008 Paraquat-inducible protein B
 1  2  5 10 ---------------------------||-|-||----  10 [S]  COG3009 Uncharacterized protein conserved in bacteria
 5  7 10 18 -------------------|-||-|||-|-||----|-  20 [G]  COG3010 Putative N-acetylmannosamine-6-phosphate epimerase
 3  6 10 12 ----------------||------|--||||-|--||-  12 [S]  COG3011 Uncharacterized protein conserved in bacteria
 3  4  8 13 ------------------|---|----||-||||----  13 [S]  COG3012 Uncharacterized protein conserved in bacteria
 2  2  4  8 -|--------------------------|-||------   8 [S]  COG3013 Uncharacterized conserved protein
 1  2  2  4 ------------------------------|---|---   4 [S]  COG3014 Uncharacterized protein conserved in bacteria
 2  2  3  6 ---------------------|------|-|-------   6 [MP] COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance
 2  3  4  4 --------------|------------|--|---|---   4 [S]  COG3016 Uncharacterized iron-regulated protein
 1  2  7 13 ---------------------------|||||||----  13 [M]  COG3017 Outer membrane lipoprotein involved in outer membrane biogenesis
 1  2  2  4 ------------------------------|---|---   5 [S]  COG3018 Uncharacterized protein conserved in bacteria
 3  5  7  7 --------|-----|------------|--||--|-|-   8 [R]  COG3019 Predicted metal-binding protein
 3  4  7 13 ----------------|-|---------|-||---||-  14 [S]  COG3021 Uncharacterized protein conserved in bacteria
 5  8 13 20 --------------|----|--|--|-||-||||||-|  20 [S]  COG3022 Uncharacterized protein conserved in bacteria
 2  4 11 20 -------------------|-------|||||||-|||  31 [V]  COG3023 Negative regulator of beta-lactamase expression
 1  3  8 16 ---------------------------||-||||-||-  16 [S]  COG3024 Uncharacterized protein conserved in bacteria
 2  4  8 13 --|------------------------||-|||--||-  14 [S]  COG3025 Uncharacterized conserved protein
 1  2  5 10 ---------------------------||-|||-----  10 [T]  COG3026 Negative regulator of sigma E activity
 3  6 12 25 --------------------|--||--|||||-|-|||  25 [S]  COG3027 Uncharacterized protein conserved in bacteria
 1  2  7 13 ---------------------------|||||||----  13 [S]  COG3028 Uncharacterized protein conserved in bacteria
 2  2  4 10 ----------------------|-----|-||------  10 [C]  COG3029 Fumarate reductase subunit C
 4  7 10 21 --||------------------|-|--||-||-|--|-  22 [R]  COG3030 Protein affecting phage T7 exclusion by the F plasmid
 2  2  3  3 --------------|-------------|-|-------   4 [U]  COG3031 Type II secretory pathway, component PulC
 4  4  6  8 ---|------|--------|--------|-||------  10 [E]  COG3033 Tryptophanase
 2  4  6 15 --------------|------------||-|---|-|-  18 [S]  COG3034 Uncharacterized protein conserved in bacteria
 1  2  5  8 ---------------------------||-||-|----   8 [S]  COG3036 Uncharacterized protein conserved in bacteria
 3  4  7 15 ----------------------|-|||-|-||------  22 [S]  COG3037 Uncharacterized protein conserved in bacteria
 2  4 11 18 -----------------|---------|||||||-|||  37 [C]  COG3038 Cytochrome B561
 3  7  9 14 --|||-----------------|-----|-|-||--|-  86 [L]  COG3039 Transposase and inactivated derivatives, IS5 family
 2  4  7 11 ----------------------|----||-|---|||-  16 [M]  COG3040 Bacterial lipocalin
 3  5  8 12 ----------------|--------|--||||--|-|-  14 [S]  COG3041 Uncharacterized protein conserved in bacteria
 2  4  6 11 ------|---------------------|-|-||--|-  12 [R]  COG3042 Putative hemolysin
 1  3  6 12 ---------------------------||-||--|-|-  12 [C]  COG3043 Nitrate reductase cytochrome c-type subunit
 3  4  4  4 -|-----|--|-------------------|-------   4 [R]  COG3044 Predicted ATPase of the ABC class
 1  3  6 14 ---------------------------||-|-||--|-  14 [S]  COG3045 Uncharacterized protein conserved in bacteria
 3  5  6  6 |--|-------------|------------|----||-   6 [R]  COG3046 Uncharacterized protein related to deoxyribodipyrimidine photolyase
 1  3  9 16 ---------------------------||||||--|||  19 [M]  COG3047 Outer membrane protein W
 3  3  5  9 -------------------|----|--||-|-------   9 [E]  COG3048 D-serine dehydratase
 4  5  7 10 --|--------------|------||--|-|-----|-  11 [M]  COG3049 Penicillin V acylase and related amidases
 1  1  3  8 ----------------------------|-||------   8 [L]  COG3050 DNA polymerase III, psi subunit
 3  3  5  9 -------------------|-----|--|-||------  10 [C]  COG3051 Citrate lyase, alpha subunit
 3  3  5  9 -------------------|-----|--|-||------  10 [C]  COG3052 Citrate lyase, gamma subunit
 3  3  5  9 -------------------|-----|--|-||------  10 [C]  COG3053 Citrate lyase synthetase
 1  1  3  8 ----------------------------|-||------   8 [R]  COG3054 Predicted transcriptional regulator
 2  3  5 10 -------------------|--------|-||----|-  13 [S]  COG3055 Uncharacterized protein conserved in bacteria
 1  1  3  8 ----------------------------|-||------   8 [M]  COG3056 Uncharacterized lipoprotein
 1  1  3  8 ----------------------------|-||------   8 [L]  COG3057 Negative regulator of replication initiationR
 2  3  5 10 --------------|------------||--|----|-  10 [O]  COG3058 Uncharacterized protein involved in formate dehydrogenase formation
 1  2  4  9 ----------------------------|-||--|---   9 [S]  COG3059 Predicted membrane protein
 1  1  3  8 ----------------------------|-||------   8 [KE] COG3060 Transcriptional regulator of met regulon
 1  1  3  8 ----------------------------|-||------   8 [M]  COG3061 Cell envelope opacity-associated protein A
 1  3  6 12 ---------------------------||-||--|-|-  12 [P]  COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase
 1  2  7  9 ---------------------------|||||||----   9 [NU] COG3063 Tfp pilus assembly protein PilF
 1  1  3  8 ----------------------------|-||------   8 [M]  COG3064 Membrane protein involved in colicin uptake
 1  1  4  9 ----------------------------||||------  12 [M]  COG3065 Starvation-inducible outer membrane lipoprotein
 1  1  3  8 ----------------------------|-||------   8 [L]  COG3066 DNA mismatch repair protein
 1  1  4  9 ---------------------------||-||------   9 [P]  COG3067 Na+/H+ antiporter
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3068 Uncharacterized protein conserved in bacteria
 1  1  3  7 ----------------------------|-||------  13 [C]  COG3069 C4-dicarboxylate transporter
 2  5 12 19 -----------------------|||-||-||||-|||  20 [K]  COG3070 Regulator of competence-specific genes
 1  2  7 13 ---------------------------|||||||----  13 [H]  COG3071 Uncharacterized enzyme of heme biosynthesis
 1  1  4  9 ---------------------------||-||------   9 [F]  COG3072 Adenylate cyclase
 1  2  6 11 ---------------------------||||||-----  11 [T]  COG3073 Negative regulator of sigma E activity
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3074 Uncharacterized protein conserved in bacteria
 2  2  4  9 ---|------------------------|-||------   9 [E]  COG3075 Anaerobic glycerol-3-phosphate dehydrogenase
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3076 Uncharacterized protein conserved in bacteria
 3  4  8 14 -------------------|-----|--||||----||  16 [L]  COG3077 DNA-damage-inducible protein J
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3078 Uncharacterized protein conserved in bacteria
 1  1  5 10 ---------------------------|||||------  10 [S]  COG3079 Uncharacterized protein conserved in bacteria
 2  2  4 10 ----------------------|-----|-||------  10 [C]  COG3080 Fumarate reductase subunit D
 1  1  4  9 ---------------------------||-||------   9 [R]  COG3081 Nucleoid-associated protein
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3082 Uncharacterized protein conserved in bacteria
 1  1  4  9 ---------------------------||-||------  10 [R]  COG3083 Predicted hydrolase of alkaline phosphatase superfamily
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3084 Uncharacterized protein conserved in bacteria
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3085 Uncharacterized protein conserved in bacteria
 3  3  6 11 ---------------|---|-------||-||------  12 [T]  COG3086 Positive regulator of sigma E activity
 1  2  7 13 ---------------------------|||||||----  13 [D]  COG3087 Cell division protein
 2  3  7 15 ------------------|--------|||-|---||-  22 [O]  COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes
 1  1  4  9 ---------------------------||-||------   9 [S]  COG3089 Uncharacterized protein conserved in bacteria
 4  5  9 13 -------------------|--|-|--||-||---||-  43 [G]  COG3090 TRAP-type C4-dicarboxylate transport system, small permease component
 2  2  6 16 ------------------------||-||-||------  16 [S]  COG3091 Uncharacterized protein conserved in bacteria
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3092 Uncharacterized protein conserved in bacteria
 4  5 10 13 ----------------|--|--|----|||||---||-  21 [R]  COG3093 Plasmid maintenance system antidote protein
 1  2  4 10 ----------------------------|-||-|----  10 [S]  COG3094 Uncharacterized protein conserved in bacteria
 1  1  3  8 ----------------------------|-||------   8 [D]  COG3095 Uncharacterized protein involved in chromosome partitioning
 1  1  3  8 ----------------------------|-||------   8 [D]  COG3096 Uncharacterized protein involved in chromosome partitioning
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3097 Uncharacterized protein conserved in bacteria
 1  1  4  9 ---------------------------||-||------   9 [S]  COG3098 Uncharacterized protein conserved in bacteria
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3099 Uncharacterized protein conserved in bacteria
 1  1  4  9 ---------------------------||-||------   9 [S]  COG3100 Uncharacterized protein conserved in bacteria
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3101 Uncharacterized protein conserved in bacteria
 1  1  3  8 ----------------------------|-||------   9 [S]  COG3102 Uncharacterized protein conserved in bacteria
 2  2  5 11 ------------------------|--||-||------  15 [T]  COG3103 SH3 domain protein
 5  9 12 19 -----------|||--------||||--|||--|-|--  32 [E]  COG3104 Dipeptide/tripeptide permease
 1  1  4  9 ---------------------------||-||------   9 [S]  COG3105 Uncharacterized protein conserved in bacteria
 1  2  4 12 ----------------------------|-||----|-  12 [R]  COG3106 Predicted ATPase
 1  1  5 10 ---------------------------|||||------  10 [R]  COG3107 Putative lipoprotein
 1  2  5 13 ----------------------------|-||---||-  19 [S]  COG3108 Uncharacterized protein conserved in bacteria
 1  1  4  9 ---------------------------||-||------  10 [T]  COG3109 Activator of osmoprotectant transporter ProP
 1  1  3  8 ----------------------------|-||------   9 [S]  COG3110 Uncharacterized protein conserved in bacteria
 1  1  4  9 ---------------------------||-||------  18 [S]  COG3111 Uncharacterized conserved protein
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3112 Uncharacterized protein conserved in bacteria
 1  2  6 12 ----------------------------||||||----  12 [R]  COG3113 Predicted NTP binding protein (contains STAS domain)
 1  1  4  9 ---------------------------||-||------  10 [U]  COG3114 Heme exporter protein D
 1  1  5 10 ---------------------------|||||------  10 [D]  COG3115 Cell division protein
 1  2  6 12 ---------------------------||||||-----  12 [D]  COG3116 Cell division protein
 1  2  7 13 ---------------------------|||||||----  15 [S]  COG3117 Uncharacterized protein conserved in bacteria
 2  4  9 20 ----------------------|----||||||--||-  21 [O]  COG3118 Thioredoxin domain-containing protein
 4  7 10 19 --||-|------|---------|----||--|---||-  54 [P]  COG3119 Arylsulfatase A and related enzymes
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3120 Uncharacterized protein conserved in bacteria
 3  5  8 14 -----------------||--------|||--|---||  86 [NU] COG3121 P pilus assembly protein, chaperone PapD
 1  1  3  7 ---------------------------|||--------   7 [S]  COG3122 Uncharacterized protein conserved in bacteria
 1  2  4  8 ---------------------------||-|-|-----   8 [S]  COG3123 Uncharacterized protein conserved in bacteria
 1  1  3  7 ---------------------------||-|-------   7 [S]  COG3124 Uncharacterized protein conserved in bacteria
 2  4  7 17 ------------------------|--|||--|--||-  20 [C]  COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4
 1  2  4 10 ---------------------------||-|-----|-  11 [S]  COG3126 Uncharacterized protein conserved in bacteria
 1  3  6 13 ---------------------------||-|-|--||-  13 [Q]  COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component
 1  2  5  7 ---------------------------|||-----||-   7 [S]  COG3128 Uncharacterized iron-regulated protein
 2  2  4  8 ------------|--------------||-|-------   8 [R]  COG3129 Predicted SAM-dependent methyltransferase
 1  1  3  7 ---------------------------||-|-------   7 [J]  COG3130 Ribosome modulation factor
 1  2  5  8 ---------------------------||||-|-----  14 [P]  COG3131 Periplasmic glucans biosynthesis protein
 1  2  4  8 ---------------------------||-|-----|-   8 [S]  COG3132 Uncharacterized protein conserved in bacteria
 1  2  4  9 ---------------------------||--||-----  10 [M]  COG3133 Outer membrane lipoprotein
 1  1  3  7 ---------------------------|||--------   7 [S]  COG3134 Predicted outer membrane lipoprotein
 3  4  6 11 ------------------|---|----||-|-----|-  12 [Q]  COG3135 Uncharacterized protein involved in benzoate metabolism
 1  2  4  8 ---------------------------||-|-----|-   8 [R]  COG3136 Uncharacterized membrane protein required for alginate biosynthesis
 1  1  3  7 ----------------------------|||-------   7 [M]  COG3137 Putative salt-induced outer membrane protein
 1  2  4  8 ---------------------------||-|----|--  10 [E]  COG3138 Arginine/ornithine N-succinyltransferase beta subunit
 1  1  3  7 ---------------------------||-|-------   7 [S]  COG3139 Uncharacterized protein conserved in bacteria
 1  1  3  8 ----------------------------|-||------   8 [S]  COG3140 Uncharacterized protein conserved in bacteria
 1  1  3  7 ---------------------------||-|-------   7 [S]  COG3141 Uncharacterized protein conserved in bacteria
 3  4  9 17 -------------------|----||--||||---||-  18 [P]  COG3142 Uncharacterized protein involved in copper resistance
 1  2  4  8 ---------------------------||-|-|-----   9 [NT] COG3143 Chemotaxis protein
 3  5  7 13 ---------------|-------||--||-|-|-----  14 [N]  COG3144 Flagellar hook-length control protein
 4  6 10 19 ------------|---|-----|----||||-|--||-  23 [L]  COG3145 Alkylated DNA repair protein
 2  5  7 10 ----------------||---------|-|--|--||-  10 [S]  COG3146 Uncharacterized protein conserved in bacteria
 1  2  5  9 ---------------------------||||-|-----   9 [S]  COG3147 Uncharacterized protein conserved in bacteria
 1  1  3  7 ---------------------------||-|-------  10 [S]  COG3148 Uncharacterized conserved protein
 1  2  4  4 ---------------------------||-|-|-----   5 [U]  COG3149 Type II secretory pathway, component PulM
 1  2  5  9 ---------------------------||-|||-----  15 [R]  COG3150 Predicted esterase
 1  1  4  8 ---------------------------||||-------   8 [S]  COG3151 Uncharacterized protein conserved in bacteria
 2  3  7 13 ------------------------||-||-|----||-  30 [S]  COG3152 Predicted membrane protein
 5  6 10 18 --|-------------|-----|-||-||-|----||-  32 [R]  COG3153 Predicted acetyltransferase
 1  3  5 11 ---------------------------||-|-|---|-  11 [I]  COG3154 Putative lipid carrier protein
 1  1  3  7 ---------------------------||-|-------   7 [Q]  COG3155 Uncharacterized protein involved in an early stage of isoprenoid biosynthesis
 1  3  7  8 ---------------------------||||-|--||-   9 [U]  COG3156 Type II secretory pathway, component PulK
 1  3  5 10 ---------------------------||-|-|---|-  28 [S]  COG3157 Hemolysin-coregulated protein (uncharacterized)
 4  6 10 18 --|-------------------|--|-||||-|--||-  23 [P]  COG3158 K+ transporter
 1  3  7 11 ---------------------------||||||--|--  11 [S]  COG3159 Uncharacterized protein conserved in bacteria
 1  1  3  7 ---------------------------||-|-------   7 [K]  COG3160 Regulator of sigma D
 3  8 12 19 |||---||--------------|----||-||||----  19 [H]  COG3161 4-hydroxybenzoate synthetase (chorismate lyase)
 4  4  6 10 ------------------|---|-|--|||--------  10 [S]  COG3162 Predicted membrane protein
 1  2  5  9 ---------------------------||||-|-----   9 [S]  COG3164 Predicted membrane protein
 1  2  7 12 ---------------------------|||||||----  12 [S]  COG3165 Uncharacterized protein conserved in bacteria
 2  5  9 14 ----------------||---------||||-||--|-  15 [NU] COG3166 Tfp pilus assembly protein PilN
 1  2  5  6 ---------------------------|-||-||----   6 [NU] COG3167 Tfp pilus assembly protein PilO
 1  2  5  6 ---------------------------|-||-||----   6 [NU] COG3168 Tfp pilus assembly protein PilP
 2  3  5  6 ------------------|--------|-||-----|-   6 [S]  COG3169 Uncharacterized protein conserved in bacteria
 1  2  5  6 ---------------------------|-||-||----   8 [NU] COG3170 Tfp pilus assembly protein FimV
 1  2  4 10 ---------------------------||--|-|----  11 [S]  COG3171 Uncharacterized protein conserved in bacteria
 3  3  5 11 ----------------------|--|-||--|------  11 [H]  COG3172 Predicted ATPase/kinase involved in NAD metabolism
 5  8 11 16 --||--------------|---|-||-|----|--|||  24 [R]  COG3173 Predicted aminoglycoside phosphotransferase
 4  9  9 10 |-||---|--|---|------------|----|---|-  14 [S]  COG3174 Predicted membrane protein
 2  5  7 11 -----------||--------------|----|--|||  11 [O]  COG3175 Cytochrome oxidase assembly factor
 3  5  7 11 ----------------|-----|----|--|-|--||-  14 [R]  COG3176 Putative hemolysin
 7 11 16 23 --||----------|-|--|--|-||-||--||||-||  37 [S]  COG3177 Uncharacterized conserved protein
 1  3  6 10 ---------------------------|-|--||-||-  10 [R]  COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases
 2  3  5  5 ------------------|--------||--|----|-   8 [R]  COG3179 Predicted chitinase
 5  6  8 15 ----------------|--|--|-|--||-|-----|-  15 [R]  COG3180 Putative ammonia monooxygenase
 4  6  9 11 -------------------|--|-|--||-|||---|-  21 [S]  COG3181 Uncharacterized protein conserved in bacteria
 3  5  8 10 ----------------------|-|--|--|-||-||-  19 [S]  COG3182 Uncharacterized iron-regulated membrane protein
 3  4  6  6 --|---------------|--------||-|-----|-   6 [V]  COG3183 Predicted restriction endonuclease
 1  3  4  8 ---------------------------|-|---|--|-   8 [S]  COG3184 Uncharacterized protein conserved in bacteria
 3  6  8 10 ----------------||----|----|--|-|--||-  15 [ER] COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins
 2  4  6  6 --------------------|------|--|-|--||-   6 [E]  COG3186 Phenylalanine-4-hydroxylase
 6  9 11 20 --|--------------|||--|----||-|-|-|-|-  21 [O]  COG3187 Heat shock protein
 2  4  7 12 -----------------|---------|||--|---||  70 [NU] COG3188 P pilus assembly protein, porin PapC
 5  7  8 17 ----|----|------------|-|--||---|---|-  17 [S]  COG3189 Uncharacterized conserved protein
 3  4  6 13 --------------------|---|--||-|-|-----  13 [N]  COG3190 Flagellar biogenesis protein
 5  7  8 15 -----|---|--------|---|----|----|--||-  21 [EQ] COG3191 L-aminopeptidase/D-esterase
 3  3  4  8 -------------------|----|--||---------   8 [E]  COG3192 Ethanolamine utilization protein
 4  6  9 12 --------||-------|------|--||---|--||-  16 [R]  COG3193 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol
 2  4  5 11 -----------||--------------||-------|-  13 [F]  COG3194 Ureidoglycolate hydrolase
 4  6  7 11 ------------------|---|-|--|----|--||-  12 [S]  COG3195 Uncharacterized protein conserved in bacteria
 2  2  3  4 ----------------------|----||---------   4 [S]  COG3196 Uncharacterized protein conserved in bacteria
 1  4  7 11 ---------------------------|--|-|||||-  13 [P]  COG3197 Uncharacterized protein, possibly involved in nitrogen fixation
 1  2  3  4 ---------------------------|--|--|----   4 [S]  COG3198 Uncharacterized protein conserved in bacteria
 3  6  7  9 ---||||--||----------------|----------  11 [S]  COG3199 Uncharacterized conserved protein
 2  4  5 13 ----------------------|----|------|||-  15 [E]  COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase
 3  4  6 14 ----------------------|--|-||--|--|---  15 [H]  COG3201 Nicotinamide mononucleotide transporter
 3  4  4  6 -------------|------|--------|-------|  19 [C]  COG3202 ATP/ADP translocase
 1  2  5 12 ----------------------------|-||||----  67 [M]  COG3203 Outer membrane protein (porin)
 2  2  3  6 -----------------|---------||---------  12 [S]  COG3204 Uncharacterized protein conserved in bacteria
 2  4  5  5 ---|-----------------------|--|--|-|--   6 [S]  COG3205 Predicted membrane protein
 4  7 12 18 --------------||||---------||||||--||-  43 [M]  COG3206 Uncharacterized protein involved in exopolysaccharide biosynthesis
 2  2  3  3 -----------|---------------|--|-------   3 [Q]  COG3207 Pyoverdine/dityrosine biosynthesis protein
 4  7  8 12 ----------------|-----|||--||---|---|-  19 [Q]  COG3208 Predicted thioesterase involved in non-ribosomal peptide biosynthesis
 3  6  7 12 --|--------------------||--||---|---|-  71 [M]  COG3209 Rhs family protein
 3  7 11 15 ----------------||-|-------|||-|||||--  79 [U]  COG3210 Large exoproteins involved in heme utilization or adhesion
 3  5  7  9 ----------------|-------|--|--|---|||-  12 [R]  COG3211 Predicted phosphatase
 4  6  9 13 --|----------------|----||-|--|--|-||-  18 [S]  COG3212 Predicted membrane protein
 1  3  5  8 ---------------------------|--|-||--|-  12 [P]  COG3213 Uncharacterized protein involved in response to NO
 3  4  6 12 ------------------|---|----||------||-  12 [S]  COG3214 Uncharacterized protein conserved in bacteria
 1  2  4  5 ---------------------------|-|--||----   5 [NU] COG3215 Tfp pilus assembly protein PilZ
 2  3  4  7 -----------------|---------|--|-----|-   8 [S]  COG3216 Uncharacterized protein conserved in bacteria
 3  4  7 13 ---|------------|----------||-|----||-  13 [R]  COG3217 Uncharacterized Fe-S protein
 1  3  5  8 ---------------------------|-|----|||-   8 [R]  COG3218 ABC-type uncharacterized transport system, auxiliary component
 1  2  3  5 ---------------------------|---|-|----   6 [S]  COG3219 Uncharacterized protein conserved in bacteria
 2  4  7  9 -----------------------|---|---|||-||-  11 [S]  COG3220 Uncharacterized protein conserved in bacteria
 7  8 12 20 ---|----|-------|--|--|-||-||-|----||-  30 [P]  COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component
 3  4  4  5 ----------------||----|----|----------   5 [S]  COG3222 Uncharacterized protein conserved in bacteria
 2  2  5 10 ------------------------||-||--|------  10 [S]  COG3223 Predicted membrane protein
 3  4  4  4 ----------------|||--------|----------   5 [S]  COG3224 Uncharacterized protein conserved in bacteria
 3  4  4  5 ----------------||---|-----|----------   6 [N]  COG3225 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component
 2  2  3  7 ----------------------|----||---------   9 [S]  COG3226 Uncharacterized protein conserved in bacteria
 4  5  6  7 --|-------------|------||--|--|-------  11 [E]  COG3227 Zinc metalloprotease (elastase)
 2  4  5  9 ----------------||---------||---|-----   9 [S]  COG3228 Uncharacterized protein conserved in bacteria
 2  4  4  5 ------------------|--------|-----|--|-   6 [P]  COG3230 Heme oxygenase
 4  5  5  7 ------------------|---|--|-|--------|-   8 [J]  COG3231 Aminoglycoside phosphotransferase
 2  4  7  8 ------------------|--------||-|||---|-   9 [E]  COG3232 5-carboxymethyl-2-hydroxymuconate isomerase
 3  5  5  8 -|---|----------------|----|----|-----   8 [R]  COG3233 Predicted deacetylase
 2  3  4  6 ---------------|-----------||---|-----   6 [S]  COG3234 Uncharacterized protein conserved in bacteria
 1  2  3  4 ---------------------------|--|--|----   4 [S]  COG3235 Predicted membrane protein
 4  4  5  5 ----------------|-|---|----||---------   5 [S]  COG3236 Uncharacterized protein conserved in bacteria
 4  5  8 17 ----------------|-----|-||-||------||-  26 [S]  COG3237 Uncharacterized protein conserved in bacteria
 5  7 10 15 ----------------|-|---||||-||--|----|-  21 [S]  COG3238 Uncharacterized protein conserved in bacteria
 4  7  8 10 ----------------||----|-|--|----|--||-  27 [I]  COG3239 Fatty acid desaturase
 2  3  7  7 ----------------|----------||||||-----   9 [IR] COG3240 Phospholipase/lecithinase/hemolysin
 1  2  3  4 ---------------------------|-|---|----   4 [C]  COG3241 Azurin
 1  3  6 11 ---------------------------||||-|---|-  11 [S]  COG3242 Uncharacterized protein conserved in bacteria
 4  6  9 14 ------|----------|----|----|--|-|--|||  17 [I]  COG3243 Poly(3-hydroxyalkanoate) synthetase
 1  3  5  6 ---------------------------|--|-||-|--  10 [C]  COG3245 Cytochrome c5
 5  7  7  9 ------|-----------||--|----|----|---|-  15 [S]  COG3246 Uncharacterized conserved protein
 5  7  9 16 --|-------------|-----|-||-||---|---|-  22 [S]  COG3247 Uncharacterized conserved protein
 1  1  3  6 ---------------------------||-|-------   6 [M]  COG3248 Nucleoside-binding outer membrane protein
 1  2  4  4 ---------------------------|-||-----|-   4 [S]  COG3249 Uncharacterized protein conserved in bacteria
 4  5  7 13 ---------|-----|--------||--||------|-  24 [G]  COG3250 Beta-galactosidase/beta-glucuronidase
 3  5  6  8 ----------------------|-|--||---|---|-   9 [S]  COG3251 Uncharacterized protein conserved in bacteria
 1  6  6  6 ||||--||------------------------------   6 [H]  COG3252 Methenyltetrahydromethanopterin cyclohydrolase
 5  6  7 14 ---||----||-------|---|-|-------------  14 [S]  COG3253 Uncharacterized conserved protein
 3  5  5 15 ----|-------------------|---|-----|-|-  19 [S]  COG3254 Uncharacterized conserved protein
 5  7 10 11 ----|-|-|||---|---------|--|-------||-  17 [I]  COG3255 Putative sterol carrier protein
 3  5  7 10 --------||-------|---------|----||--|-  10 [P]  COG3256 Nitric oxide reductase large subunit
 2  3  4 10 ------------------|--------||-------|-  10 [R]  COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization
 2  5  5  5 -----------------|---------|----|-|-|-   7 [C]  COG3258 Cytochrome c
 2  8  8  9 |||--|||--------||--------------------  16 [C]  COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit
 4  9  9 14 |||-||-|-|------------|-----|---------  20 [C]  COG3260 Ni,Fe-hydrogenase III small subunit
 4  9  9 13 |||-||-|-|------------|-----|---------  19 [C]  COG3261 Ni,Fe-hydrogenase III large subunit
 3  4  4  8 --|--|----------------|-----|---------  12 [C]  COG3262 Ni,Fe-hydrogenase III component G
 3  4  6 10 -------------------|----|--||-|-----|-  10 [P]  COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain
 2  4  7 15 -----------------|---------||--||--||-  24 [M]  COG3264 Small-conductance mechanosensitive channel
 5  8 12 19 -----------||---|-|---|----||-||||--|-  24 [G]  COG3265 Gluconate kinase
 1  1  3  7 ---------------------------||-|-------   8 [S]  COG3266 Uncharacterized protein conserved in bacteria
 2  2  4  5 ----------------------|----||-|-------   9 [U]  COG3267 Type II secretory pathway, component ExeA (predicted ATPase)
 5  6  6  8 ---|---------|---|----|----|--------|-  10 [S]  COG3268 Uncharacterized conserved protein
 2  8  8  9 |||||-|||-----------------------------  20 [R]  COG3269 Predicted RNA-binding protein, contains TRAM domain
 3  4  5 10 -----||------------------|--|-|-------  10 [S]  COG3270 Uncharacterized conserved protein
 2  5  6  7 |-|------------------------|----|||---  18 [R]  COG3271 Predicted double-glycine peptidase
 2  3  5  9 |-|------------------------||-|-------   9 [S]  COG3272 Uncharacterized conserved protein
 2  7  7  8 |-||-|||--|---------------------------  10 [S]  COG3273 Uncharacterized conserved protein
 2  4  5  9 -------------------------|--|-|-|----|  10 [S]  COG3274 Uncharacterized protein conserved in bacteria
 3  4  5 10 -------------------|----|---|-|-----|-  13 [T]  COG3275 Putative regulator of cell autolysis
 4  9 11 16 -||-|--|-|----|------------||--|--|-|-  17 [J]  COG3276 Selenocysteine-specific translation elongation factor
 4 12 13 15 |||||||||-||||------------------------  15 [J]  COG3277 RNA-binding protein involved in rRNA processing
 1  4  7 13 ---------------------------|--|-|||||-  20 [O]  COG3278 Cbb3-type cytochrome oxidase, subunit 1
 3  6 11 23 -------------------|---|||-||||-|--||-  42 [KT] COG3279 Response regulator of the LytR/AlgR family
 5  7  8 10 ---------|------|-|---|----||---|---|-  10 [G]  COG3280 Maltooligosyl trehalose synthase
 3  4  4  6 ----------|-----------|----|----|-----   6 [G]  COG3281 Uncharacterized protein, probably involved in trehalose biosynthesis
 1  1  4  9 ---------------------------||-||------  10 [KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism
 3  6  9 13 ----------------|------||--||-|-|--||-  16 [QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism
 3  4  4  8 ----------------------|-|--|--------|-  18 [L]  COG3285 Predicted eukaryotic-type DNA primase
 2  4  5  6 -|---|-||-|---------------------------   6 [S]  COG3286 Uncharacterized protein conserved in archaea
 3  5  6  7 -|-----|--------|----------|--|-----|-  10 [S]  COG3287 Uncharacterized conserved protein
 3  6 12 23 ----------------||----|----||-||||-|||  36 [C]  COG3288 NAD/NADP transhydrogenase alpha subunit
 3  3  5  9 ----------------------|-||--|-|-------  20 [T]  COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism
 4  8  9  9 |||--||---|-------------||----|-------  87 [R]  COG3291 FOG: PKD repeat
 2  3  4  4 ----------------||-----------||-------   5 [T]  COG3292 Predicted periplasmic ligand-binding sensor domain
 6  8  9 12 --|-------------|||---|--|------|--||- 148 [L]  COG3293 Transposase and inactivated derivatives
 3  4  5  5 -|-|----|-|-------|-------------------   5 [S]  COG3294 Uncharacterized conserved protein
 2  4  5  5 ------------------|----------||-|--|--   5 [S]  COG3295 Uncharacterized protein conserved in bacteria
 4  5  5  5 ----------------|||-----|--|----------   5 [S]  COG3296 Uncharacterized protein conserved in bacteria
 1  2  4  5 ---------------------------||-|----|--   6 [U]  COG3297 Type II secretory pathway, component PulL
 1  2  2  5 ---------------------------------||---   6 [L]  COG3298 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB
 2  3  5  8 ------------------------|---||-|-|----  13 [S]  COG3299 Uncharacterized homolog of phage Mu protein gp47
 3  5  7  9 -----------------|------|--||---|--||-  12 [T]  COG3300 MHYT domain (predicted integral membrane sensor domain)
 3  3  5  9 ------|-||------------------|--|------  10 [P]  COG3301 Formate-dependent nitrite reductase, membrane component
 2  3  4  9 --------------|-------------|--|----|-  19 [R]  COG3302 DMSO reductase anchor subunit
 1  2  3  7 ----------------------------|--|--|---   7 [P]  COG3303 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit
 2  3  5 11 ----------------------|-----|-||---|--  11 [S]  COG3304 Predicted membrane protein
 2  2  3  4 ----------------------|------||-------   4 [S]  COG3305 Predicted membrane protein
 1  4  6 11 ----------------------------|--|-||-||  25 [M]  COG3306 Glycosyltransferase involved in LPS biosynthesis
 5 10 18 29 ---------------|||-|---|||-|||||||||||  46 [M]  COG3307 Lipid A core - O-antigen ligase and related enzymes
 1  2  4  5 ---------------------------|--|-||----   5 [S]  COG3308 Predicted membrane protein
 1  3  4  5 -----------------------------|-|-||---   6 [S]  COG3309 Uncharacterized virulence-associated protein D
 1  2  4  5 -----------------------------||-||----   5 [S]  COG3310 Uncharacterized protein conserved in bacteria
 1  3  5 11 ----------------------------|||-|---|-  25 [K]  COG3311 Predicted transcriptional regulator
 1  2  5 11 ---------------------------||-||-|----  11 [C]  COG3312 F0F1-type ATP synthase, subunit I
 1  3  6 12 ---------------------------||-|-|--||-  16 [R]  COG3313 Predicted Fe-S protein
 3  5  6 11 -------------------|---||---|-|-----|-  16 [S]  COG3314 Uncharacterized protein conserved in bacteria
 6  7  9 12 --|-------------|--|--|-|--|--||----|-  55 [Q]  COG3315 O-Methyltransferase involved in polyketide biosynthesis
 5  8 10 12 -|-|--|-------|-------|-|---||-----||-  37 [L]  COG3316 Transposase and inactivated derivatives
 1  2  6 12 ---------------------------||-||||----  12 [M]  COG3317 Uncharacterized lipoprotein
 3  4  6 11 --------------------|---|--||-|--|----  12 [R]  COG3318 Predicted metal-binding protein related to the C-terminal domain of SecA
 4  6  7 15 ----------------|-----|-|--||---|---|-  24 [Q]  COG3319 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases
 5  7  7  9 -----------||---|-----|-|--|--------|-  15 [Q]  COG3320 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes
 4  7  7 12 ----------------|-----|||---|---|---|-  90 [Q]  COG3321 Polyketide synthase modules and related proteins
 2  4  7  7 --|---|--------------------||-|----||-  12 [T]  COG3322 Predicted periplasmic ligand-binding sensor domain
 4  5  5 10 -------------------|--|||--|----------  11 [S]  COG3323 Uncharacterized protein conserved in bacteria
 4  6 10 15 --|-------------------|-|--||-|||--||-  25 [R]  COG3324 Predicted enzyme related to lactoylglutathione lyase
 4  4  5  6 ---|-------|------------|---|-|-------   9 [G]  COG3325 Chitinase
 3  6  8 13 --|---------------------||-||----||-|-  13 [S]  COG3326 Predicted membrane protein
 4  5  5  6 ---------|------------|-|---|-------|-   7 [K]  COG3327 Phenylacetic acid-responsive transcriptional repressor
 6 11 12 18 --|-|----|-------|----|||||-|---|---|- 106 [L]  COG3328 Transposase and inactivated derivatives
 4  5  5  6 ----------------||----|-|----------|--   7 [R]  COG3329 Predicted permease
 3  5  5  5 ---------------|||-----||-------------   6 [S]  COG3330 Uncharacterized protein conserved in bacteria
 1  2  3 11 ------------------------|||-----------  13 [R]  COG3331 Penicillin-binding protein-related factor A, putative recombinase
 3  4  4  4 -----------|------------|--|----|-----   4 [S]  COG3332 Uncharacterized conserved protein
 4  6  9 10 -------------------|--|-|--||-|||---|-  16 [S]  COG3333 Uncharacterized protein conserved in bacteria
 3  4  5 11 --------------|---------|---------|||-  11 [S]  COG3334 Uncharacterized conserved protein
 7 12 14 17 --|-|-|--|------|||---|-||--|---||--|- 155 [L]  COG3335 Transposase and inactivated derivatives
 4  4  4  9 ------------------|---|-|-----------|-  10 [S]  COG3336 Predicted membrane protein
 3  3  3  3 ------|-------|---------|-------------   3 [L]  COG3337 Uncharacterized protein predicted to be involved in DNA repair
 3  5  6  9 ----------------|-------|-----||--|-|-   9 [P]  COG3338 Carbonic anhydrase
 4  8  9 13 |-|-------------||-----||-------|--||-  15 [S]  COG3339 Uncharacterized conserved protein
 6  6  7 13 ----------------|-||--|-|---|--|------  14 [E]  COG3340 Peptidase E
 3  5  5  5 -----------||--|-------||-------------   6 [R]  COG3341 Predicted double-stranded RNA/RNA-DNA hybrid binding protein
 4  4  6  6 ---|----|||-------------|--|----------   9 [S]  COG3342 Uncharacterized conserved protein
 1  2  3 10 ------------------------|||-----------  10 [K]  COG3343 DNA-directed RNA polymerase, delta subunit
 7 10 12 16 --|--------|----||-|--|||--||-|-----|-  47 [L]  COG3344 Retron-type reverse transcriptase
 3  3  5  5 ---------------|--------||--|-|-------   5 [G]  COG3345 Alpha-galactosidase
 3  6  8 15 -----------||---------|----|----|--|||  20 [S]  COG3346 Uncharacterized conserved protein
 4  5  5  8 ----|------------|------|---|-------|-  14 [S]  COG3347 Uncharacterized conserved protein
 3  4  4  5 ---|------------||----|---------------  13 [S]  COG3349 Uncharacterized conserved protein
 5  7  8  9 --|-|---|------||-----------|--|--|---  10 [S]  COG3350 Uncharacterized conserved protein
 1  4  4  6 -|-|||--------------------------------   8 [N]  COG3351 Putative archaeal flagellar protein D/E
 1  4  4  6 -|-|||--------------------------------   6 [N]  COG3352 Putative archaeal flagellar protein C
 1  4  4  5 -|-|||--------------------------------   5 [N]  COG3353 Putative archaeal flagellar protein F
 1  4  4  6 -|-|||--------------------------------   7 [N]  COG3354 Putative archaeal flagellar protein G
 2  6  6  6 -|||--||-|----------------------------  20 [K]  COG3355 Predicted transcriptional regulator
 2  6  7  8 |--||-||||----------------------------   8 [S]  COG3356 Predicted membrane protein
 2  5  6  6 ---|-|||||----------------------------   6 [K]  COG3357 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon
 4  4  4  4 ---|--------------|---|------|--------   4 [S]  COG3358 Uncharacterized conserved protein
 2  5  5  6 |-||-------------------||-------------   6 [L]  COG3359 Predicted exonuclease
 3  5  5  6 ---|------------------|----|----|---|-   6 [S]  COG3360 Uncharacterized conserved protein
 3  3  3  4 ---|------------------|-|-------------   4 [S]  COG3361 Uncharacterized conserved protein
 1  4  4  4 ||-|---|------------------------------   4 [F]  COG3363 Archaeal IMP cyclohydrolase
 1  5  5  5 |-||--||------------------------------   5 [R]  COG3364 Zn-ribbon containing protein
 1  5  5  5 |-||--||------------------------------   5 [S]  COG3365 Uncharacterized protein conserved in archaea
 1  5  5  5 -|||--||------------------------------  12 [S]  COG3366 Uncharacterized protein conserved in archaea
 4  7  7  8 |--||--|-------||-------------------|-  10 [S]  COG3367 Uncharacterized conserved protein
 2  4  4  6 ----|||--|----------------------------   7 [R]  COG3368 Predicted permease
 3  6  6  7 |-|-|-----|---------------------|---|-   8 [S]  COG3369 Uncharacterized conserved protein
 2  3  5  6 ----|-|-|||---------------------------   8 [S]  COG3370 Uncharacterized protein conserved in archaea
 2  3  5  7 ----||--|||---------------------------  12 [S]  COG3371 Predicted membrane protein
 3  7  8 10 --|||||-||------|---------------------  11 [S]  COG3372 Uncharacterized conserved protein
 1  3  3  5 -|--||--------------------------------   5 [S]  COG3373 Uncharacterized protein conserved in archaea
 3  4  5  6 ----|-|-||-----|----------------------   8 [S]  COG3374 Predicted membrane protein
 3  3  3  4 ----|-----|-------|-------------------   5 [S]  COG3375 Uncharacterized conserved protein
 6  8  8 11 ----|----|--|---------|-|---|---|-|---  11 [P]  COG3376 High-affinity nickel permease
 2  4  4  6 --|-|-|-----------------|-------------   6 [S]  COG3377 Uncharacterized conserved protein
 6  7  9 14 ---|-----|------|-----|-||--||--|-----  16 [R]  COG3378 Predicted ATPase
 2  3  4  4 ---|-|---||---------------------------   5 [S]  COG3379 Uncharacterized conserved protein
 3  5  5  5 ---|------------||---------|----|-----   5 [R]  COG3380 Predicted NAD/FAD-dependent oxidoreductase
 3  4  6 11 ---|-----|------------------|-|||-----  27 [R]  COG3381 Uncharacterized component of anaerobic dehydrogenases
 4  7 11 13 -------||||------------|||-||---|---|-  13 [S]  COG3382 Uncharacterized conserved protein
 4  5  5 10 |---|----|--------------|-----------|-  12 [R]  COG3383 Uncharacterized anaerobic dehydrogenase
 5  8 10 14 --|-|----|--|----------|---||--||--|--  18 [S]  COG3384 Uncharacterized conserved protein
 6 11 11 11 --|||----|------|||-----|---|---|---|- 183 [L]  COG3385 FOG: Transposase and inactivated derivatives
 6  8 12 17 ----|----|-|------|-----|--|||-||--||-  40 [G]  COG3386 Gluconolactonase
 7 11 12 16 -||-|----|-||---|-----||--------|--||-  25 [G]  COG3387 Glucoamylase and related glycosyl hydrolases
 1  5  5  6 --|||-||------------------------------   6 [S]  COG3388 Uncharacterized protein conserved in archaea
 1  4  4  5 --|||-|-------------------------------   5 [S]  COG3389 Uncharacterized protein conserved in archaea
 1  5  5  7 --|||||-------------------------------   9 [S]  COG3390 Uncharacterized protein conserved in archaea
 8 12 13 20 --|-|----|------|-|--||||--||---|---|-  48 [S]  COG3391 Uncharacterized conserved protein
 3  3  3  5 -------------------|----|---------|---   6 [L]  COG3392 Adenine-specific DNA methylase
 6  6  6  8 --|-------------|----||-|----------|--   8 [R]  COG3393 Predicted acetyltransferase
 2  3  4 10 ------------------------|---|-|-----|-  12 [S]  COG3394 Uncharacterized protein conserved in bacteria
 4  6  7 13 ----------------||-|----|---|--|----|-  18 [S]  COG3395 Uncharacterized protein conserved in bacteria
 4  6  6  6 ---------|--------|-----|---|---|---|-  14 [S]  COG3396 Uncharacterized conserved protein
 2  2  5  6 ------------------------||-||-|-------   7 [S]  COG3397 Uncharacterized protein conserved in bacteria
 1  4  4  4 -|||--|-------------------------------   6 [S]  COG3398 Uncharacterized protein conserved in archaea
 1  2  2  5 ---------------------------------||---   5 [S]  COG3399 Uncharacterized protein conserved in bacteria
 2  2  2  4 --------------|-------------------|---   4 [S]  COG3400 Uncharacterized protein conserved in bacteria
 2  2  2  5 ------------------------|---------|---   8 [R]  COG3401 Fibronectin type 3 domain-containing protein
 3  3  3  7 ---|------------------|-|-------------   7 [S]  COG3402 Uncharacterized conserved protein
 3  3  3  3 ---|--------------|-----|-------------   4 [S]  COG3403 Uncharacterized conserved protein
 5  6  6  7 ----|----------|--||---|-|------------   8 [E]  COG3404 Methenyl tetrahydrofolate cyclohydrolase
 3  4  4  7 --------------|---------|---|-------|-   7 [G]  COG3405 Endoglucanase Y
 6  8  9 13 ---||----|-|||-------|--||------------  17 [I]  COG3407 Mevalonate pyrophosphate decarboxylase
 7  9  9 12 --|-||---|-|----|-|-----|-----------|-  21 [G]  COG3408 Glycogen debranching enzyme
 6 10 10 17 --|-------------|||---|||-----|-|---|-  70 [M]  COG3409 Putative peptidoglycan-binding domain-containing protein
 4  4  4  4 ----|----|-|------------|-------------   4 [S]  COG3410 Uncharacterized conserved protein
 7  8  8  8 ---|----------|||||-----|-------|-----   9 [C]  COG3411 Ferredoxin
 4  5  6 11 ------------------||----||--|-------|-  12 [S]  COG3412 Uncharacterized protein conserved in bacteria
 2  4  5  6 ---||-|-||----------------------------  35 [R]  COG3413 Predicted DNA binding protein
 3  5  8 15 ----------------------|||||-|-||------  38 [G]  COG3414 Phosphotransferase system, galactitol-specific IIB component
 6  7  7  8 ---|--|--|------|-|-----|-----------|-  61 [L]  COG3415 Transposase and inactivated derivatives
 1  3  5  5 ---------------------------|||--|---|-   5 [S]  COG3416 Uncharacterized protein conserved in bacteria
 1  2  3 10 ----------------------------|-|---|---  10 [R]  COG3417 Collagen-binding surface adhesin SpaP (antigen I/II family)
 1  1  3  8 ---------------------------||-|-------   8 [NUO] COG3418 Flagellar biosynthesis/type III secretory pathway chaperone
 1  2  4  4 ---------------------------|-|--||----   9 [NU] COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1
 2  4  5  7 --------|------------------|----||--|-   7 [P]  COG3420 Nitrous oxidase accessory protein
 2  4  4  4 --------------------------|----|-||---   5 [S]  COG3421 Uncharacterized protein conserved in bacteria
 2  4  7 13 --|------------------------||--|-|-||-  15 [S]  COG3422 Uncharacterized conserved protein
 1  2  3  8 ----------------------------|--|-|----  11 [K]  COG3423 Predicted transcriptional regulator
 3  3  3  5 ------------------|---|-|-------------  10 [Q]