(order) Methanosarcinales - 1 genome Functional categories Fun All J A K L B D Y V T M N Z W U O C G E F H I P Q R S COGs 1,462 153 2 60 94 3 9 -  19 32 41 14 -  1 20 65 129 49 125 52 105 25 78 15 220 248 proteins 3,388 174 2 187 312 3 27 -  78 220 110 44 -  1 42 128 293 116 289 67 180 40 271 115 689 405 Distribution of COGs by number of proteins proteins 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 25 26 31 34 36 66 70 76 COGs 959 234 100 42 34 14 12 10 6 4 4 5 3 7 4 1 2 1 4 2 3 2 2 1 1 1 1 1 1 1

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
|||---|-|---|------------------|-----|----------|----------------- 76 [R] COG3291 FOG: PKD repeat
|||||||||||||||||||||||||-||||||||||||----|||||||||||||||||||||||| 70 [QR] COG0500 SAM-dependent methyltransferases
|-||----|-----|-||||-|||-||||||----|||----|||||-||--|--|--||||||-- 66 [T] COG2202 FOG: PAS/PAC domain
|||||||||--|-|||||||||||||----||||||||----|||||-||-||||||||||||||| 36 [R] COG0457 FOG: TPR repeat
|-|---------------|||------||||----|-----------------------|||||-- 34 [T] COG3920 Signal transduction histidine kinase
||||--|||--------|---|---|-|||------|-----|||||-||--|--|-------||| 31 [S] COG1520 FOG: WD40-like repeat
|||-|||||||||----|||||--------|-----|-----|||||-|||||||||||||-|--- 26 [C] COG1145 Ferredoxin
-||||||||-|||----|||||----||||||||||||----|||||-||||---|||||||||-- 25 [P] COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component
|-|-----|--------------------------------------------------------- 25 [K] COG4742 Predicted transcriptional regulator
--|-||--|----||---||||----|||--|||||-|||--|||||-|||--|||---|||||-- 22 [L] COG2801 Transposase and inactivated derivatives
--|------------------------||-----||-|-----|||---------|---||-|--- 22 [L] COG4584 Transposase and inactivated derivatives
||||||||||||||||||||||---|||||||||||||----|||||-|||||||||||||||||| 21 [M] COG0438 Glycosyltransferase
|||-----||-|-||-|---||-----||||--|||||----||-||-||--|--|---|||-|-| 21 [R] COG0655 Multimeric flavodoxin WrbA
--|--|-------------|---------------------------------------------- 21 [L] COG5421 Transposase
--|-------------|----------||-|||||||||---||||||-------|---||-|--- 20 [L] COG1484 DNA replication protein
--|----------------||---------|-|||--|-----------|---------||--|-- 20 [L] COG3666 Transposase and inactivated derivatives
||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||| 19 [GEPR] COG0477 Permeases of the major facilitator superfamily
|||||||||||||---||||||----|||||||-||||----|||||-||-|||||--||||||-- 19 [K] COG0640 Predicted transcriptional regulators
--|||||||-|||---||||||||--|||||||-||||----|||||-||||---||||||||--- 19 [E] COG0747 ABC-type dipeptide transport system, periplasmic component
|-||----|-----|-||||-|-----||||---|-||----|||---||-----|---|||||-- 19 [T] COG2203 FOG: GAF domain
|-||--|||----|||-|||-|--||-||-|----|||----|||||-|||||--|||||||||-- 18 [T] COG0784 FOG: CheY-like receiver
|-||----|----||-||||||||-|||||||||||||----|||||-|||||||||||||||||| 17 [T] COG0642 Signal transduction histidine kinase
|-||---||--|----||||||----|||||||||||||---|||||-||||||||--||||||-- 17 [K] COG1309 Transcriptional regulator
--||--||---|------|-----------|-----------|||||--------|---------- 16 [L] COG3677 Transposase and inactivated derivatives
--|--------|----|-|-----------------------||||-----|-------------- 15 [L] COG1662 Transposase and inactivated derivatives, IS1 family
|||------|--------|||---------|-----------------------------|-|--- 15 [C] COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains
--|-|------|-------|-|--||-||-|-----||----|||-|--|-----|----|-|--- 15 [S] COG3391 Uncharacterized conserved protein
|-|-----|-----------|---------------------------------------|-|--- 15 [R] COG5012 Predicted cobalamin binding protein
--|-||-------||-|-||-|||--||||----||||----|||||-||-||||||||||||||| 14 [H] COG0407 Uroporphyrinogen-III decarboxylase
|||||||||-||||||||||||||--|||||||||||||---|||||-||||||||||||||||-| 14 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
--|||||||-|||---||||||||-||||||||||||||||||||||-||||---||||||||--- 14 [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
-||||||||-|||----|||||----|---|||||||||---|||||-||||---|||||||||-- 14 [P] COG0609 ABC-type Fe3+-siderophore transport system, permease component
-||||||||--||----|||||----|---|-|||||||-|||||||-||||---|||||||||-- 14 [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components
|-||||||||||||||-|||-|---||||||||||||||||-|||||-||-|||||||-|||||-- 14 [V] COG1131 ABC-type multidrug transport system, ATPase component
||||----|||||---|||||||||||||-|||||||||||||||||||||||||||||||||||| 14 [V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component
|||||||||||||---||||-|-----||-||--|-||-----------|-----|----|-|--- 13 [R] COG0535 Predicted Fe-S oxidoreductases
|||||||||--||---||||||||--||||||||||||||--|||||-|||||||||||||||||| 13 [L] COG0582 Integrase
--|||||||-|||---||||||||-||||||||||||||||||||||-||||---||-|||||--- 13 [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
--|||||||-|||---||--||||-||---|||||||||||||||||-||||---||||||||--- 12 [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
|||||||||||||||-||||||||-|||||||||||||----|||||-|||||||||||||||||| 12 [R] COG0517 FOG: CBS domain
--||||--|-|||||||-||||---|||||||-||||||||||||||-|||||||||||||||||| 12 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 
|||||||||||||----|-|||----||||||||||||----|||||-||--||||---|||||-- 12 [K] COG1846 Transcriptional regulators
--|||||||-|||---||--||||-||---||||||||-||||||||-||||---||||||||--- 12 [E] COG4608 ABC-type oligopeptide transport system, ATPase component
||||----||||-----||||||||-|||-||||||||----|||||-||-|-|||--||||||-- 11 [V] COG0577 ABC-type antimicrobial peptide transport system, permease component
||||-----|--------||-------||--------------------|-----|---||||--- 11 [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases
--|----------------||------|||------|-----------||-|--------|-|--- 11 [Q] COG3315 O-Methyltransferase involved in polyketide biosynthesis
--|----------|----|||------||-|---|--|----|--||-||----------|----- 11 [L] COG3344 Retron-type reverse transcriptase
-||--|--|||||||-|-||-------|-------|-|------------------||-|||||-- 10 [EQ] COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit
||||||||||||||||||||||---||||||||||||||||||||||-|||||||||||||||||| 10 [M] COG0463 Glycosyltransferases involved in cell wall biogenesis
|||-||--||-|-||--||--|----|||--|---|||-------|---||-||||---|||||-- 10 [S] COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
-||||||||-||-----|------------------------------------------------ 10 [M] COG1361 S-layer domain
|||---||||------|||||------||-------||----|||||-||--||||||-|||||--  9 [G] COG0662 Mannose-6-phosphate isomerase
|||||--||||||---||||||----||||||||||||----|||||-||||||||||||||||--  9 [C] COG0778 Nitroreductase
||||--|||||||----|||||--|-||||||||||||||||-||-|-|-|----|---|||----  9 [P] COG1122 ABC-type cobalt transport system, ATPase component
||||||||||-|||--||||-|----|||-||---|||||--|||||-|||-||||||||||||||  9 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component
--|||||||--||----|||-|--||----|---|||||||--------|-----|----||----  9 [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
|-|||---|--------|||-------------|--------||||--------|--|--|-||-|  9 [S] COG1598 Uncharacterized conserved protein
|||-----||------||||-|----|||-||---||-----|||||-||||||||---|||||--  8 [E] COG0347 Nitrogen regulatory protein PII
|||||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  8 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins
|||||||||||||-|-|-||-|----||||-|||||||----|||||-||||-|||---|||||||  8 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins
||||--||||-||----|||||----||||||||||||||||-||-|---|--------|||----  8 [P] COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
|||||||||||||||-|||||-----|||||-----------|||-|--|--||||---|||||--  8 [C] COG0644 Dehydrogenases (flavoproteins)
-|||||||-|||----||||-|---|-||-------------|||-|-----|---||--------  8 [L] COG0675 Transposase and inactivated derivatives
|||||||||||||--------|--------------|-----------------------------  8 [K] COG1378 Predicted transcriptional regulators
|-||---------|||--||--||||--------|-||----||-----|------------|---  8 [C] COG1413 FOG: HEAT repeat
|-|--------------|||----------|-----------------------------------  8 [R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family
--|---------------||-|----||-----|---------------------|---|-|||--  8 [L] COG3293 Transposase and inactivated derivatives
||||---||||||||-||||||---||||-||||||||----|||||-||-|---|--||||||||  7 [P] COG0053 Predicted Co/Zn/Cd cation transporters
||||||--||||||||--|||-||--|||||||||||||||||||||-|||||--|---|||||||  7 [E] COG0531 Amino acid transporters
||||--|||---|||-|||-||--|||||-|||||||||||||||||-||||||||||||||||--  7 [V] COG0534 Na+-driven multidrug efflux pump
|||||||||||||-||||||||--|||||-||||||||----||||||||--||||||||||||||  7 [M] COG0668 Small-conductance mechanosensitive channel
|-|||||||-|||||||||||||||-|||-||-|||||----||||||||||||||||||||||||  7 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
--|--|-|-|---|||-|||||||---|||||||||||----|||||-||--|--|||-|||||--  7 [G] COG0726 Predicted xylanase/chitin deacetylase
|-||||||||||||||-|||-|----||||||||||||----|||||-||-||--|||-|||||--  7 [V] COG0842 ABC-type multidrug transport system, permease component
|-|-----|---------||-|--------|-|-||||----|||||-||-----|---|||||--  7 [C] COG1600 Uncharacterized Fe-S protein
-||-----|--------||--|-------------------------------|-----|---|--  7 [R] COG1669 Predicted nucleotidyltransferases
|||---|||||||---||------------|---|-----------|---|--------||----|  7 [R] COG1708 Predicted nucleotidyltransferases
-|||----|-------|----|--||----|-----||----|||||-||||||||||||||||||  7 [M] COG2834 Outer membrane lipoprotein-sorting protein
|||-----||--------------------------------------------------------  7 [D] COG3640 CO dehydrogenase maturation factor
|||--|||||||-||-||||-|----|||||--|||||----||||||||||||||--||||||--  6 [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases
|||||||||||||||-|-||-|||--|||||------|----|||||-||-|||||||||||||||  6 [H] COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases
||||--||||------||||------|||||---|||-|||||||-|--|--|--|---||||---  6 [S] COG0392 Predicted integral membrane protein
||||||||||||||||||||||||||||||||||||||--||||||||||||||||||||||||||  6 [O] COG0459 Chaperonin GroEL (HSP60 family)
--|----------||-|-||||----|||-----|-||----|||||-||--||||||-|||||--  6 [R] COG0523 Putative GTPases (G3E family)
-||||||||-|||---------------------------------------|---||-|||||||  6 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis
|||||||||||||---||||-|---|||||||||||-||-|||||||-||--|--|---|||||--  6 [P] COG0704 Phosphate uptake regulator
--|||||||-||||||||||||||--||||||||||||----||||||||||||||||||||||||  6 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
|||------|--------|||---------|-----------------------------|-|---  6 [P] COG1348 Nitrogenase subunit NifH (ATPase)
-||---|-|---|-----|||------||----|--------|--||-|------|---||-----  6 [JD] COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system
||||||||||-|-----|-|||----|---||||||||----|||||-||||||||---|||||--  6 [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
||||||--|||-------------------------------------------------------  6 [R] COG3269 Predicted RNA-binding protein, contains TRAM domain
--||-|-----|------||-|---------------|----|------------|----|-----  6 [L] COG3385 FOG: Transposase and inactivated derivatives
--|--------|-------||-----||||--||---|-------|---|---||----||-||--  6 [L] COG3547 Transposase and inactivated derivatives
|||||||||||||||-||||-|-----||||---|-||----||||||||--|--|---|||||||  5 [O] COG0071 Molecular chaperone (small heat shock protein)
||||---|-||--||--|||-|||--||||||||||||----|||-|-||-|-|||--||||||-|  5 [R] COG0110 Acetyltransferase (isoleucine patch superfamily)
|-||||-------||-||||||||||||||||||||||||||||||||||||||||||||||||||  5 [L] COG0210 Superfamily I DNA and RNA helicases
||||||--|||||---|-||||----||||-|----||----|||||-||||-||||||||||---  5 [C] COG0247 Fe-S oxidoreductase
|||||||||||||||-|||||||||-||||||||||||----|||||-||||||||||||||||||  5 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase
||||||||||||||||||||||----|||||||||||||---|||||-||||||||--||||||--  5 [R] COG0456 Acetyltransferases
||||||||||||||||--||-|----||||------||-----------|-----|--|||-|---  5 [O] COG0464 ATPases of the AAA+ class
||||||||||||||--||||---------------------------------------||-|---  5 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction
|||-|--------||||-|||-----||||||||-||||||||||||--|----------|||---  5 [P] COG0474 Cation transport ATPase
|-||||--|-|||||||||||||||-||||||||||||----||||||||||||||||||||||||  5 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
|||||||||||||---||||||--|-|||||--|-||-----|||||-||--||||||||||||||  5 [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase
|-||||--|-||-||||-||||---|||||||||||||----|||||||||||||||||||-||||  5 [P] COG0607 Rhodanese-related sulfurtransferase
||||--|||-------||||||--|||||-||||||||----||||||||||||||||||||||||  5 [R] COG0628 Predicted permease
||||-|-||----------|-------||--|||||--|||||||-|-|||||---|||-||-|-|  5 [V] COG0732 Restriction endonuclease S subunits
--|-----|---------||--||------------------|||||-|||||--|||||||||||  5 [U] COG0823 Periplasmic component of the Tol biopolymer transport system
||||--||-|||-|||-|-|-|--|||||-||||||||----|||||-||-|-|||---|||||--  5 [R] COG1011 Predicted hydrolase (HAD superfamily)
|||||||||||||---|||||---|--||-||--||-|----|||||-|------||||---||--  5 [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit
|||-----||--------------------------------------------------------  5 [C] COG1029 Formylmethanofuran dehydrogenase subunit B
-|||--||||-------|------||-----------|-----------|--------|-------  5 [R] COG1033 Predicted exporters of the RND superfamily
|||-|||||||||---||--|------||-||||||------|||||-||||---|----------  5 [O] COG1180 Pyruvate-formate lyase-activating enzyme
--|-----------|---||--||---||-------||----------||-|||||---|||||--  5 [S] COG1262 Uncharacterized conserved protein
-||-|-||--||-----|--|------||----|-|--------------|-----|||---|--|  5 [R] COG1373 Predicted ATPase (AAA+ superfamily)
|||||||||||||--------|----|||-|-----||----|||||-||||-|||---|||||--  5 [K] COG1522 Transcriptional regulators
|-|-----|--|-------|||---------------|----|--|--|---|--|----------  5 [H] COG1541 Coenzyme F390 synthetase
|||---||--||-----||||------------------------|------------|-------  5 [R] COG1672 Predicted ATPase (AAA+ superfamily)
|-|-|-|||-|||-|-||||||----||||||-|||||----|||||--|-|-|||---|||||||  5 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family
--|---|||---||||--||-------||-|-----------------|-||---|----|||---  5 [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase
--|-------------|----|----|||||-----------|||||-||-----|||||||||--  5 [M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases
--|----------|||-|||||--------------------------|----------|||||--  5 [R] COG2319 FOG: WD40 repeat
||||----|---------------------------------------------------------  5 [S] COG2881 Uncharacterized protein conserved in archaea
--|-----|------------------------------------|--||----------|--|--  5 [T] COG3322 Predicted periplasmic ligand-binding sensor domain
--|-----|-----------|---------|---------------------|-------------  5 [O] COG4870 Cysteine protease
|-|-------|--------|------|---|-----||----------------------------  5 [KT] COG4978 Transcriptional regulator, effector-binding domain/component
--|---------------------------|------------------|----------------  5 [S] COG5513 Predicted secreted protein
|||-||-||||||||-||||-|----||||||-|||||----||||||||||||||--||||||--  4 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  4 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
||||||||||||||||||||||----||||||||||||----||||||||||||||||||||||--  4 [R] COG0491 Zn-dependent hydrolases, including glyoxylases
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  4 [F] COG0518 GMP synthase - Glutamine amidotransferase domain
||||--|||||-|---||||||--||-||---||||||-||||||||-||||-||---||||----  4 [P] COG0569 K+ transport systems, NAD-binding component
|||-----||------||||-------||-|-||-|||----|||-------------|-------  4 [R] COG0701 Predicted permeases
|||||||||||||---||||-|---||||||---||||----|||||-||--|--|---|||||--  4 [R] COG0714 MoxR-like ATPases
|||-----||---||---|||---|-----||||-||-----|||||||||||--||||-------  4 [C] COG0716 Flavodoxins
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  4 [P] COG0725 ABC-type molybdate transport system, periplasmic component
-|||--|||-||------||-|---------||---------|||||-||--|--||||-|-|---  4 [R] COG0727 Predicted Fe-S-cluster oxidoreductase
--||--|||--------|||-|--||----|----|||----|||||-||--|--||||||-||--  4 [NT] COG0840 Methyl-accepting chemotaxis protein
||||--|||||||-----------------|----|||----|||-|---------||---|-|--  4 [K] COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain
||||||---||||||-|-||||----|||||||||||||---|||||-||-|-|||||||||||-|  4 [C] COG1012 NAD-dependent aldehyde dehydrogenases
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  4 [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit
|||-----||--------||----------------------------------------|-----  4 [C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit
|||||||||||||-------||--|-----------------|||||-|||||||||||-------  4 [O] COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
--||---||---||||-|-|||||--|||-|||--|||----|||||-||-||--|---|||||--  4 [R] COG1073 Hydrolases of the alpha/beta superfamily
||||||-|||||-----|||-|----|||||-----------|||-|-||--|--|||||||||||  4 [C] COG1146 Ferredoxin
|||-----||--------------------------------------------------------  4 [C] COG1153 Formylmethanofuran dehydrogenase subunit D
|||---||||-------|------------|---------------|-------------------  4 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II
|-||--||--|-|---|||||||||||||-||||||||-----||||-||-----|------||--  4 [R] COG1266 Predicted metal-dependent membrane protease
|||||||||-||-||-------------------------------------------|-------  4 [R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation
--||--|||--------|-|----||----|----|||----|||||-||-----|--|||-||--  4 [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins
--||--------------||-|--|-|||-||---|||----|||||--|-|-------||-||||  4 [S] COG1357 Uncharacterized low-complexity proteins
|||----|||-|-----|-||---------|-----|---------------------|-------  4 [C] COG1592 Rubrerythrin
||||||--|--||-----||||----|||-||--||||----|||||-||-||--|--|||-||--  4 [K] COG1733 Predicted transcriptional regulators
||||--||||-||---|--|--||------------------|||||----|-------||-|---  4 [G] COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes
||||--||||------||||-|----|||-||||||||----|||||-||||||||--|---||--  4 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
|||-----||--------------------------------------------------------  4 [S] COG2043 Uncharacterized protein conserved in archaea
|||||||||||||-------------||--|--------------|---|-|---|---||-||--  4 [NU] COG2064 Flp pilus assembly protein TadC
--||--|||--------|-|----||----|-----||----|||||-||--|--|--|||-||--  4 [NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain
||||||||||||||---|||||----|||-|-||||||----|||||-||-||--|--|||||--|  4 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold
--|-||----||-||-||||||||--||||----||||----|||||-||-|||||||||||||||  4 [H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis
-||---------------|--|-------------------------------|-----|---|--  4 [S] COG2361 Uncharacterized conserved protein
--|-|||||-|||-----------------------------------------------------  4 [S] COG2512 Uncharacterized membrane-associated protein/domain
--||||--|--||||-||||||----|---|||-|||||-------|--|||-|||||-|||----  4 [P] COG2608 Copper chaperone
--|----|------------||----|-----------|-------------------|-------  4 [K] COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen
--|--|--|--|------||-|----|------|---|-----||-|-------||----|-|---  4 [L] COG3335 Transposase and inactivated derivatives
--||-|---------------|----------||---------|||-------------||||---  4 [L] COG3436 Transposase and inactivated derivatives
--|-----|---------------------------------------------------|-|---  4 [R] COG3894 Uncharacterized metal-binding protein
--|-------------|---||--||----|-----------||||||||||||||||||||||||  4 [M] COG4591 ABC-type transport system, involved in lipoprotein release, permease component
--|-||--|---------------------------------------------------------  4 [K] COG4738 Predicted transcriptional regulator
|||-||--||-|-||-||||-|----|||-||--|||||---|||||--|--||||---|||||--  3 [P] COG0004 Ammonia permease
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  3 [I] COG0020 Undecaprenyl pyrophosphate synthase
|||---||||||-||-||||-|----||||||-|||||----||||||||||||||--||||||--  3 [E] COG0066 3-isopropylmalate dehydratase small subunit
||||--||||--|||-||||||--||------||||||-||||||||-||||-||---||||----  3 [P] COG0168 Trk-type K+ transport systems, membrane components
|||||||||||||||-||||||--||||||||||||||||||||||||||--||||||||||||--  3 [H] COG0171 NAD synthase
||||||||||------||||||--||||||||||||||-|||||||||||||||||||||||||||  3 [D] COG0206 Cell division GTPase
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  3 [P] COG0226 ABC-type phosphate transport system, periplasmic component
-|||--||-|---||-||||-|----|||-|--|||||----|||||-||||||||||||||||--  3 [D] COG0239 Integral membrane protein possibly involved in chromosome condensation
||||---||----------|-------||--|||||--|||-|||-|-|||||||||||-||-|-|  3 [V] COG0286 Type I restriction-modification system methyltransferase subunit
||||----||--------||----------|----|----------|---|----------|----  3 [P] COG0310 ABC-type Co2+ transport system, permease component
|-||||--|-|||||---||-|||--||||-||-||||----|||||-||||||||--||||||||  3 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  3 [J] COG0361 Translation initiation factor 1 (IF-1)
|||-----||----|-|-||||----|||-----|--||---|||||--||----||||||||---  3 [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase
||||---|||||----||||||----|||||-----||----|||||-||--||||--|||-||--  3 [H] COG0422 Thiamine biosynthesis protein ThiC
|||---|||-------|||||---------|-----------|||-|--|-----|----------  3 [C] COG0426 Uncharacterized flavoproteins
||||||||||||-||-||||||---|||||||-|||||----|||||-||||||||||||||||--  3 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  3 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
|||||||||||||||||||||||||-||||-|||||||||||||||||||||||||||||||||||  3 [L] COG0470 ATPase involved in DNA replication
|||---||||||-||-||||-|----||||||--||||----||||||||||||||--||||||||  3 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase
|||-|||||-|||||-|-||-|---|-|||||--||||----|||||-|||-||||||||||||||  3 [P] COG0475 Kef-type K+ transport systems, membrane components
|-||||-------|||||||||||||||||||||||||||||||||||||||||||||||||||||  3 [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain
|||||||||||||||--|||-|----||||||||||||----|||||-|||||--|---|||||--  3 [G] COG0524 Sugar kinases, ribokinase family
||||||||||||-||-|||-----||-----------|----|||||-|--|--------|-----  3 [P] COG0530 Ca2+/Na+ antiporter
|-||||||||||||||-||||||||||||||||||||||||||||||||-||-|||---||-|---  3 [R] COG0561 Predicted hydrolases of the HAD superfamily
--|----------||||-||-|||--||||||-|||||----||||||||||||||---|||||||  3 [FJ] COG0590 Cytosine/adenosine deaminases
|-|||||||--||||---|-|--|--|------||-||----|||||-||||-||||||||||-||  3 [ER] COG0591 Na+/proline symporter
||||||||||||----|||||||||||---||||||||----|||||-||||||||||||||||||  3 [L] COG0608 Single-stranded DNA-specific exonuclease
||||----|--||---||||-|--------|------|----|||||-||||-|||----------  3 [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family)
|||||||||||||||-||-----|--||||-|-|||||----||||||||||||||--||--||--  3 [E] COG0620 Methionine synthase II (cobalamin-independent)
||||-||||-|||----|||-|----|||-----||||----|||-|-||---------|||--||  3 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit
|||-||||-|-|----|-||-|----|||-|-----||----|||-|-||--||||--||||||||  3 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  3 [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit
-||||||||||||||-|-||||--||-||-|--|||||-||||||||-||-||--|--||||||--  3 [R] COG0693 Putative intracellular protease/amidase
--||-----------|--||----------|---|||||||||||||-||------||||------  3 [G] COG0696 Phosphoglyceromutase
|-|---|||-|-|---||||||--|-||||--||--||------------||----||-||||---  3 [O] COG0785 Cytochrome c biogenesis protein
|-|------|------|-||||||------------------|||||-||||||||||||||||||  3 [U] COG0811 Biopolymer transport proteins
--||----|----|||||-||-||||||||||||||||||||||||||||||-|||||||||||||  3 [C] COG0822 NifU homolog involved in Fe-S cluster formation
|||------|-|----|--|||--------||||||||----|||||-||||-|||||||||----  3 [O] COG0826 Collagenase and related proteases
--||----------|--|||------||||||||||||----||||||||||-|||||||||||--  3 [E] COG1045 Serine acetyltransferase
||||||--|||-|---||||||||---||||------|----|||||-|-------|||-------  3 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes
--|||||||-||||||---|||--|-|||||-||||------|||||-|-----------------  3 [KL] COG1061 DNA or RNA helicases of superfamily II
--|-----|----||||||||||||-||||||||||||----||||||||||-|||||||||||||  3 [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes
|||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||  3 [G] COG1109 Phosphomannomutase
|||-|----|-|------|||-----||||----|-------|||||-|------|||-||-|---  3 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase
--||--||--||-|||||||||||--||||||||||||||||||||||||||||||||||||||||  3 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components
|||-----||--------------------------------------------------------  3 [C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit
|||||||||||||||||-||-|----|||||-----||-------||--|--||||--||||||--  3 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)
|||-----||--------------------------------------------------------  3 [C] COG1229 Formylmethanofuran dehydrogenase subunit A
||||-------||-----||-|----|||-----||-|-----------------|------||--  3 [Q] COG1233 Phytoene dehydrogenase and related proteins
||||||||||||||||--------------------------------------------------  3 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family
||||||--|||||||-||||||||--||||-|||||||-|||||||||||||||||---|||||||  3 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
--|-------------|----------||-|---|-||----|||||--|-----|---||-||--  3 [C] COG1251 NAD(P)H-nitrite reductase
|-|-||--|||||----||--|----|---------||----|||||-|||||--|--||||||--  3 [E] COG1280 Putative threonine efflux protein
|||||||||||||----|---||||-||||||||||||----|||-|-----|---------|---  3 [K] COG1321 Mn-dependent transcriptional regulator
|||---|||---------------------|-----------------|-----------------  3 [R] COG1342 Predicted DNA-binding proteins
|||-||||||---||-||--||-----||-||--||||----|||||-|-----------|-----  3 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family
--||----|-|-|||||-||||----|||||-||--||||------|-||--||||--|||-|---  3 [O] COG1404 Subtilisin-like serine proteases
|||-|||||||------|------------|-----------------|-----------------  3 [S] COG1433 Uncharacterized conserved protein
|||||||||||||||||-------------------------------------------------  3 [J] COG1503 Peptide chain release factor 1 (eRF1)
|-|---|||----------|----------------------------------------------  3 [S] COG1572 Uncharacterized conserved protein
|-|-||-----|-||---------------------------|||||-|--|--------------  3 [S] COG1584 Predicted membrane protein
||||||||||-|||||--------------------------------------------------  3 [L] COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
-||||||||--||-----------------------------------------------------  3 [N] COG1681 Archaeal flagellins
--|--------------|||-------------------------|-----------|--|-||--  3 [N] COG1724 Predicted periplasmic or secreted lipoprotein
|||||||||||||||||----------||-------||----------|||--||---|||-||--  3 [L] COG1793 ATP-dependent DNA ligase
|||---||||--|-----------------|---||||----|||||--|-|--------------  3 [R] COG1988 Predicted membrane-bound metal-dependent hydrolases
|-|-----|--------|||----------------------------------------------  3 [S] COG2006 Uncharacterized conserved protein
|-||||-|||-||----||--|--------|||----------------|------------||--  3 [S] COG2013 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  3 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB
|-|||||||-------|-||||----|||||-----||----||--|-||--||||--||-|||--  3 [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis
--|---||----|---||-----------------|---------|--------------------  3 [G] COG2152 Predicted glycosylase
|-|-|||||------------|--------------------------------------------  3 [C] COG2191 Formylmethanofuran dehydrogenase subunit E
|-||||-||-|||||-|||||||||-|||||||||||||---|||||-||||-|||||||||||--  3 [P] COG2217 Cation transport ATPase
|||-----||--------------------------------------------------------  3 [C] COG2218 Formylmethanofuran dehydrogenase subunit C
--|----------||---||-|-----||------------------------------||-||--  3 [M] COG2335 Secreted and surface protein containing fasciclin-like repeats
-||-|||||-|-|-----------------|-----------|||---------------------  3 [C] COG2414 Aldehyde:ferredoxin oxidoreductase
|||----||-|-----|-----------------|-||----------------------------  3 [S] COG2445 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  3 [R] COG2520 Predicted methyltransferase
--||---|------|------------||-------------|||||--|||-------|||||--  3 [P] COG3119 Arylsulfatase A and related enzymes
-|||----||-|------------------------------------------------------  3 [K] COG3355 Predicted transcriptional regulator
-|||----||--------------------------------------------------------  3 [S] COG3366 Uncharacterized protein conserved in archaea
-|||----|---------------------------------------------------------  3 [S] COG3398 Uncharacterized protein conserved in archaea
--|-||||---|-|-----|-|---------------|----------------------|-|---  3 [G] COG3408 Glycogen debranching enzyme
--|--|-------------||-----|||----||--|-----------------|---||-|---  3 [L] COG3464 Transposase and inactivated derivatives
|||----------------|||-----|||--|----------------|---------||-||--  3 [R] COG3576 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase
--||--------------||---------------------------------------||||---  3 [C] COG3794 Plastocyanin
--||----|-|-|----|||||--|||---||||||-||||||||||-||||-|||--||||||--  3 [E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components
|||------|--------------------------------------------------------  3 [S] COG4022 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  3 [S] COG4069 Uncharacterized protein conserved in archaea
--|----------------|-------------|--------|||-|--------|----------  3 [V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
--|---------|---|-||------|||-----||||----|||||-||||---|||||||||--  3 [P] COG4149 ABC-type molybdate transport system, permease component
|-|-|||||-||------------------|------------------------|------||--  3 [C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits
|-|------|---------------------------------------|----------------  3 [S] COG4744 Uncharacterized conserved protein
--|---------------|----------------------------------------||||---  3 [S] COG4803 Predicted membrane protein
--|-------|--------|----------------------------------------------  3 [O] COG4826 Serine protease inhibitor
|-|------|--------------------------------------------------------  3 [R] COG4827 Predicted transporter
--|---------------|--|--------------------------------------------  3 [S] COG4828 Predicted membrane protein
--|---|||---------------------------------------------------------  3 [S] COG5423 Predicted metal-binding protein
--|-------------------------------|--------||||----|--------------  3 [L] COG5519 Superfamily II helicase and inactivated derivatives
--|---------------||------------------------------------------|---  3 [T] COG5635 Predicted NTPase (NACHT family)
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  2 [E] COG0006 Xaa-Pro aminopeptidase
|||-||--||---||-||||-|----||||||-|||||----||||||||||||||||||||||--  2 [E] COG0019 Diaminopimelate decarboxylase
||||||-|||---|||--||-|----|||--|-||||-----|||||-||-||------|--|---  2 [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
||||----||---|||||||||||||||||||||||||----|||||-||||||||||||||||||  2 [J] COG0042 tRNA-dihydrouridine synthase
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||--  2 [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
||||--||||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  2 [E] COG0065 3-isopropylmalate dehydratase large subunit
|||---||||------|-||----------|-----------|||-|---------|||-------  2 [O] COG0068 Hydrogenase maturation factor
||||--||||--||----||-------||--|---|-|----||||--|-|---------|||---  2 [E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins
|||||||||||||||-||||||----||||||--||||----||||||||||||||--||||||--  2 [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0100 Ribosomal protein S11
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  2 [F] COG0104 Adenylosuccinate synthase
|||||||||||||||-||||-|----||||||--||||----|||||-|||||--|||||||||--  2 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
|-||--|||---||||--|--|-----||-|-----||-|--|||||-||--|--|---|||||--  2 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  2 [F] COG0125 Thymidylate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  2 [G] COG0126 3-phosphoglycerate kinase
|||----||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  2 [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  2 [H] COG0142 Geranylgeranyl pyrophosphate synthase
||||--||||||-|--|||||-----|||||-||-|||----|||||-||||||||||-||-||--  2 [H] COG0157 Nicotinate-nucleotide pyrophosphorylase
|||-|||||||--||||-||----||--------------------------------------||  2 [I] COG0170 Dolichol kinase
|||||||||||||||-||||-|----||||-|||||||----|||||-||||||||||||||||||  2 [E] COG0174 Glutamine synthetase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  2 [L] COG0177 Predicted EndoIII-related endonuclease
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  2 [J] COG0186 Ribosomal protein S17
-|||--|||-|||-----||-|---------------|--||||||||||||||||---|||||--  2 [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)
--|----------||-||||||||||||||||||||||||||||||||||||||||||||||||||  2 [IQ] COG0236 Acyl carrier protein
--|--------|-|--||||||----|||||------|----|||||-||||||||||||||||||  2 [FP] COG0248 Exopolyphosphatase
|||---|||||||-----------------|-|||-|--||-|||-|-|-||--------------  2 [G] COG0269 3-hexulose-6-phosphate synthase and related proteins
--||||--|-|||||-|-||||----|||||-----||----|||||-||||||||||||||||--  2 [C] COG0277 FAD/FMN-containing dehydrogenases
--|||||||-|||||--|||-|----|||-|||-||||----|||||-||||||||--||||||||  2 [C] COG0281 Malic enzyme
|||||||||||||||-||||||||--||||||||||||----|||||-||||||||||||||||-|  2 [H] COG0294 Dihydropteroate synthase and related enzymes
--||||----|--||-||||||----||||||||||||----|||||-||||||||--||||||--  2 [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN
|||||||||||||---|-||-|----|||||---||||----|||||-||||---|||||||||--  2 [H] COG0303 Molybdopterin biosynthesis enzyme
|||-|||||||||---||||-|-----||-|------|----||||||||||||||---|||||--  2 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs
|-||--|||--||||---||||----||||||||||||----|||||-||||||||--||||||--  2 [E] COG0346 Lactoylglutathione lyase and related lyases
|||||||||||-||||----------||||||---|||----|||||-||--|-------|-|---  2 [E] COG0367 Asparagine synthase (glutamine-hydrolyzing)
|||---|||||-----||||-|--------||--||------|||||-||--|--||||----|--  2 [P] COG0370 Fe2+ transport system protein B
--|-----||------|--|----------|-----------|||-|---------|||-------  2 [C] COG0374 Ni,Fe-hydrogenase I large subunit
||||--||||||----|||||-----|||||----|||----|||||-||--||||||-||-||--  2 [H] COG0379 Quinolinate synthase
--|----------|--|-||------|--|----|-||----|||||--|---|||---|||||--  2 [R] COG0385 Predicted Na+-dependent transporter
|-|||||||-|||||-||||-|--|-|||||--|||||----|||||-||--||||||||||||--  2 [R] COG0388 Predicted amidohydrolase
--||-------|-||---|||-----|||-|||||||||||||||||-||-|-|||---|||||--  2 [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  2 [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
|||||||||||||||-||||-|----|---|--|---|----|||||--||||--|||||||||--  2 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
||||||||||||||||||||||--||||||||--||||----|||||-||----------|-----  2 [L] COG0420 DNA repair exonuclease
||||--||--||||||||-|-|---||||------|------|||-|--|---|||--|-|-----  2 [P] COG0428 Predicted divalent heavy-metal cations transporter
|||---|||||||-|-||||-|-----||-|-----||----|||-|-||---------||-----  2 [S] COG0432 Uncharacterized conserved protein
|||||||||||||---||||-|-----||---|----|----||||---|-|---|---|||||--  2 [R] COG0433 Predicted ATPase
|-||||-------|||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [O] COG0443 Molecular chaperone
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  2 [L] COG0468 RecA/RadA recombinase
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  2 [E] COG0498 Threonine synthase
|||||||||||||||||-||||----|||||-||-|||----||||||||||||||||||||||--  2 [O] COG0501 Zn-dependent protease with chaperone function
|-||--||-|-||-|--||||||||||||||||||||||||||||||-|||||--|||||||||--  2 [E] COG0520 Selenocysteine lyase
|||-||||||-|-||-||--|---|-|||-||-|-|||----|||||-||---|||---|----||  2 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [L] COG0550 Topoisomerase IA
|||||||||--------|--|-|||-----|||||||||-|||||||||||||||||||-------  2 [L] COG0551 Zn-finger domain associated with topoisomerase type I
||||||||||||------||-|-----||-|------|----|||||-||||||||---|||||--  2 [O] COG0555 ABC-type sulfate transport system, permease component
|-|||||||-|||||||||||-|||||||||||||||||||||||||-||||||||||||||||||  2 [I] COG0558 Phosphatidylglycerophosphate synthase
||||---||||||---||||-|---||||||||||||||-|||||||-|-|||--|--||||||--  2 [P] COG0573 ABC-type phosphate transport system, permease component
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  2 [P] COG0581 ABC-type phosphate transport system, permease component
--||||----||-||-|--|-|----||||-|--||||----|||||-||-||--|---|||||--  2 [CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases
|||||||||-|-|---|||||||||-||||-----|||----||||||||||||||||||||||||  2 [OU] COG0616 Periplasmic serine proteases (ClpP class)
-|||--|||||-|---||||||--|||||-||||||||||||------|-----------------  2 [R] COG0618 Exopolyphosphatase-related proteins
||||--|||||||||--|--|---|----|||||||||-||||||||-||----------------  2 [R] COG0622 Predicted phosphoesterase
||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K
--|-|||---||-||--|||-|||--|||||||-||||-|--|||||-||||||||---|||||--  2 [R] COG0637 Predicted phosphatase/phosphohexomutase
||||||||||||||||-----------|||------------------------------------  2 [O] COG0638 20S proteasome, alpha and beta subunits
-|||||||||||||||-|||||--------||-|-|||----||||||||||||||--|||-||--  2 [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
|||-----|--|-----|||----------|-----------|||||---||--------|-----  2 [R] COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)
--||--|||--------|||-|--||----|----|||----|||||-||--|--||||||-||--  2 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases
|-||||-----|-||---||-------||||------|----|||||-||-|||||---|||||||  2 [R] COG0661 Predicted unusual protein kinase
||||--||-|-|-||||-||||--|-||||||||||||----|||||-|||||--|||-|||||||  2 [I] COG0671 Membrane-associated phospholipid phosphatase
|||---||||-|----|-||----------|-----------|||-|---------|||-------  2 [C] COG0680 Ni,Fe-hydrogenase maturation factor
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  2 [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
||||||||||||----||||----------|---|-||----|||||-||||||||||||||||||  2 [H] COG0720 6-pyruvoyl-tetrahydropterin synthase
|||||||||||||---||||||----|--|||--||||----|||||-||||||||||||||||--  2 [R] COG0730 Predicted permeases
|||||||||||||||--||||---------|-------------------------|||-------  2 [C] COG0731 Fe-S oxidoreductases
-|||--|||-------|---|-|||-|------|||||----------|-||-||-|||-------  2 [R] COG0733 Na+-dependent transporters of the SNF family
--|-||--|-|||---||||||---||||||||-||||--|||||||-||||||||||||||||--  2 [P] COG0735 Fe2+/Zn2+ uptake regulation proteins
|||||||||||||---||||||||||||||||||||||----|||||-||||||||||||||||||  2 [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1
--|--------------|--|||||||||-||||||||||--||||||||||-|||||||||||--  2 [F] COG0775 Nucleoside phosphorylase
--|-----|-------|-||||----||||||||||||----|||||-||||||||||||||||||  2 [K] COG0789 Predicted transcriptional regulators
--||||--|-|||---|-||-|----||||----||||----|||||-||||||||||||||||||  2 [U] COG0805 Sec-independent protein secretion pathway component TatC
--|-----|-|-|----||||||||-||||||||||||----|||||-||||-|||||||||||||  2 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
--||--|||--------|||----||----|----|||----|||||-||--|--||||||-||--  2 [NT] COG0835 Chemotaxis signal transduction protein
--||||--|--||---|-||-|-----||-------------||||||-|--||||||||||||||  2 [C] COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J)
||||||--|---------------------------------------------------------  2 [F] COG0856 Orotate phosphoribosyltransferase homologs
--||||-||-|||---|-||-|----|||-----||||----||||||||--||||||||||||||  2 [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit
|||-|||||||||----|||||-----||-||-----|----|||-|-||------------|---  2 [C] COG1032 Fe-S oxidoreductase
|||-----||--------------------------------------------------------  2 [C] COG1036 Archaeal flavoproteins
-|||||||||||-------|----------------------|||||-||---||-----|-|---  2 [C] COG1042 Acyl-CoA synthetase (NDP forming)
--|||||||--||||--|-|-|-----||-||||||||--|-|||||-|||-||||---||-||--  2 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
|||---||||-|-----|||------|||||-|-||||----|||||--|-----|---|||||--  2 [G] COG1082 Sugar phosphate isomerases/epimerases
|-|--||||--||-|---||||----|||||||---||----|||||--|||||||---||-||--  2 [M] COG1088 dTDP-D-glucose 4,6-dehydratase
|-|-----|-------|-||-------||-|-----------|||-|-||--|---||-|-|||--  2 [M] COG1089 GDP-D-mannose dehydratase
|||||||||||||||||-||-|----------------------------------------|---  2 [R] COG1100 GTPase SAR1 and related small G proteins
--|-----|-|-|----|||||||--|---||||||||----|||||-|||--|||||||||||||  2 [E] COG1126 ABC-type polar amino acid transport system, ATPase component
|||-----||-|----||------------------------------------------------  2 [C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins
|||---||||-------|------------------------------------------------  2 [C] COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain
|||-----||-|----|-------------------------------------------------  2 [C] COG1150 Heterodisulfide reductase, subunit C
|||----|||-------|--|---------|-----------|||||-------------------  2 [C] COG1151 6Fe-6S prismane cluster-containing protein
--||-------------|--||||||-----|||||||||||------|-------||||||||--  2 [E] COG1164 Oligoendopeptidase F
||||||||--|||||||-|||-----|||-||||||||----|||||-||||||||-------|--  2 [KL] COG1199 Rad3-related DNA helicases
|-|||||||--||----|||-|----|||||||---||----|||||--|--||||---||-||--  2 [M] COG1209 dTDP-glucose pyrophosphorylase
|-|--||||---|-----||-|----|||||-----------|---|--||-|--|---||-||--  2 [R] COG1216 Predicted glycosyltransferases
||||--||||-|||||--------------------------------------------------  2 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit
--||||----|||||-||||-|----|||||---|-||----|||||-||||||||||||||||-|  2 [O] COG1225 Peroxiredoxin
||||||||||||||||-|||-|||||||||||||||||----|||-|----|---|------||--  2 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
-||||||-|-||||||--||-|--------------------------||-----|---||-||--  2 [J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing
--||------------|----|-----|||------||----||||||||-|-|||----------  2 [E] COG1246 N-acetylglutamate synthase and related acetyltransferases
|-|---|||-||||--||--------||||------------------------------|-----  2 [I] COG1260 Myo-inositol-1-phosphate synthase
--||--||----|---|--||||||||||-|---|-||----|||||-||--|--|--|||-||||  2 [C] COG1301 Na+/H+-dicarboxylate symporters
|-|---||||||----||||-|-----||||----|||-----------||||--|---||-||--  2 [E] COG1305 Transglutaminase-like enzymes, putative cysteine proteases
||||--||||--------------------------------------------------------  2 [R] COG1326 Uncharacterized archaeal Zn-finger protein
--|||||||||||||-||-|-|--|||||-||||||||----|||||-||--||||--||||||--  2 [Q] COG1335 Amidases related to nicotinamidase
|-|||||||||||-----------------------------------------------------  2 [S] COG1340 Uncharacterized archaeal coiled-coil protein
|||--||-||||----||---------||--------|----------------------------  2 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs)
|-|-------|-----||-|||--|-|||-||||||||----|||||-||||||||---|||||||  2 [K] COG1396 Predicted transcriptional regulators
|-|---|||||-|||-|-||--||--||||||--|||-----|||||-||||---|---|||||--  2 [R] COG1409 Predicted phosphohydrolases
||||||||||------||--||--||----|||||||||-|||||-|---------|||||-----  2 [R] COG1418 Predicted HD superfamily hydrolase
-||-||||--||----|-||----|-----------------------------------------  2 [G] COG1449 Alpha-amylase/alpha-mannosidase
||||--|||-------|---||----|---|-------||--|||||-||--||||||||||||-|  2 [R] COG1451 Predicted metal-dependent hydrolase
|||-----||--------------------------------------------------------  2 [C] COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)
--|---|||----------------------------|----------------------------  2 [S] COG1470 Predicted membrane protein
|-|||||||-||||||--------------------------------------------------  2 [LO] COG1474 Cdc6-related protein, AAA superfamily ATPase
||||---||----------|-|--------||||||||-----------|-------------|--  2 [K] COG1476 Predicted transcriptional regulators
||||----||------------||---|||--|---------------------------------  2 [S] COG1478 Uncharacterized conserved protein
-||---|||-||------||-|-----||-----------------|---|-|--|---||-||-|  2 [R] COG1487 Predicted nucleic acid-binding protein, contains PIN domain
|-|---||||--------------------------------------------------------  2 [S] COG1504 Uncharacterized conserved protein
||||||||||-|------------------------------------------------------  2 [J] COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain
|||||||||||||-----------------------------------------------------  2 [R] COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
--|||||||-|||---||||||--|--|||||||--------------|-|--|||||||||||||  2 [L] COG1573 Uracil-DNA glycosylase
--||||||----|---||--||-----||------|||--------|--|-----|---|||||--  2 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold
|||-----||--------------------------------------------------------  2 [C] COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit
|-|---||---|----||------------|-----||---------------------||||---  2 [S] COG1633 Uncharacterized conserved protein
|||-----||-------|||------|---|-----------------------------------  2 [S] COG1641 Uncharacterized conserved protein
-|||||-|-----||--|-|||----||||||||||||--|-|||||-||-|-|||||||||||||  2 [J] COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
--|---||--|-|-----||-|----||||||||||||----|||||--|--|--|---|||||||  2 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins
|||-----||--------------------------------------------------------  2 [S] COG1693 Uncharacterized protein conserved in archaea
|||------|------|-|-----------------------------------------------  2 [R] COG1719 Predicted hydrocarbon binding protein (contains V4R domain)
--|||||||-|-|---||||-|---|-|||-----|||----------||-----|---|||||--  2 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
--|-----|-------|--|----------|-----------|||-|---------|||-------  2 [C] COG1740 Ni,Fe-hydrogenase I small subunit
|||---||||||------------------------------------------------------  2 [R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)
--||--|||--------|------|-----|----|||----------|-------|||-------  2 [NT] COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
|||-----||-----------------------------------|--------------------  2 [S] COG1795 Uncharacterized conserved protein
||||||--||||------||||-----||-|----|-|--------|--|-----|---||||---  2 [H] COG1797 Cobyrinic acid a,c-diamide synthase
|||-----||--------------------------------------------------------  2 [S] COG1810 Uncharacterized protein conserved in archaea
|||||||||||||---|---------------|---------------------------------  2 [E] COG1812 Archaeal S-adenosylmethionine synthetase
|||---||--|-------------------------------------------------------  2 [S] COG1817 Uncharacterized protein conserved in archaea
|||------|---|----|--|-----||||-----|------||||-||------------|---  2 [GC] COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
|-||--||||--|-----------------------------------------------------  2 [P] COG1824 Permease, similar to cation transporters
--||||--|||||---|-||-|----||||----||||----|||||-||||||||||||||||||  2 [U] COG1826 Sec-independent protein secretion pathway components
--|---------|-----||-------||-|-----||-----------|----------|-|---  2 [E] COG1834 N-Dimethylarginine dimethylaminohydrolase
--|----------------|||----||||-||||||------||-|--||-||||---|||||-|  2 [I] COG1835 Predicted acyltransferases
--||------|-|-----|||-----|-----|||--|-----||||-||||||||--|||||---  2 [P] COG1840 ABC-type Fe3+ transport system, periplasmic component
|||----||-----------|---------------------------------------------  2 [S] COG1852 Uncharacterized conserved protein
--|-------------|----|--------------------|||||-||-|---|||||--|---  2 [P] COG1858 Cytochrome c peroxidase
--||--|||--------|-------|----|-----||----------||-----|---||--|--  2 [NT] COG1871 Chemotaxis protein; stimulates methylation of MCP proteins
||||||||||--------------------|-----||----------------------------  2 [S] COG1873 Uncharacterized conserved protein
||||||-||-||-----|||------|||-----|--|-----------|||---|---||-|---  2 [R] COG1878 Predicted metal-dependent hydrolase
|||-----||--------------------------------------------------------  2 [C] COG1880 CO dehydrogenase/acetyl-CoA synthase epsilon subunit
|-|--||||--||-----||||----|||||||||-||----|---|--|-|||||--||||||--  2 [M] COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes
||||||||||||||||---|-------------------------------------------|--  2 [O] COG1899 Deoxyhypusine synthase
|||-----||--------||----------------------------------------------  2 [S] COG1900 Uncharacterized conserved protein
--||||--|--|-||--|-|||----|||-|||-||||-|--|||||-||--|--|---|||||--  2 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family
|||---||||-||-----------------------------------------------------  2 [R] COG1907 Predicted archaeal sugar kinases
||||||||--||----|||||-----||--|||--|||-------||--|-----||||||||---  2 [S] COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain
|||----|||-------||--|--------||--||------|||||-||--|--|-||----|--  2 [P] COG1918 Fe2+ transport system protein A
--||||-----|-----|-|||------|-|--|---|----|||||-|||--|||||----||--  2 [L] COG1943 Transposase and inactivated derivatives
||||||||||------------||------------------------------------------  2 [S] COG1945 Uncharacterized conserved protein
-||||||||--||-----------------------------------------------------  2 [NU] COG1955 Archaeal flagella assembly protein J
|-||||||||||||||--------------------------------------------------  2 [K] COG1958 Small nuclear ribonucleoprotein (snRNP) homolog
|||-----||--------------------------------------------------------  2 [H] COG1962 Tetrahydromethanopterin S-methyltransferase, subunit H
|||-|||||||||--------------||-------------------------------------  2 [R] COG1964 Predicted Fe-S oxidoreductases
--||||-||-||----|-||-|-----||-----||||----|||||-||||---|||||||||--  2 [H] COG1977 Molybdopterin converting factor, small subunit
--|---||---------|--------|---||||-|||----|||||-|-----------------  2 [KT] COG1983 Putative stress-responsive transcriptional regulator
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  2 [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis
-||---||-|------||---------||--------------------------------|-|--  2 [S] COG1993 Uncharacterized conserved protein
||||||-||||||---||||-|-----||-|----|||----------|----|||||--|-||--  2 [R] COG1994 Zn-dependent proteases
||||||||||||||||--------------------------------------------------  2 [J] COG1997 Ribosomal protein L37AE/L43A
|||-----||-|----|-||--------------------------------------|-------  2 [C] COG2048 Heterodisulfide reductase, subunit B
|||-----||--------------------------------------------------------  2 [C] COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein)
||||--||---------|||-|----|-------||||----------||---------|||--||  2 [P] COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit
--|-||||||---||--|--||--|-----||||||||-|--------|-----------------  2 [F] COG2131 Deoxycytidylate deaminase
|||-||||-||||----|---|----||||-|||||||----|---------|--|---|||||--  2 [R] COG2151 Predicted metal-sulfur cluster biosynthetic enzyme
--|-------------------||------|-----||----------------------|-|-|-  2 [S] COG2155 Uncharacterized conserved protein
--|||||||-|||||----|----|||--------------------------||||||-------  2 [R] COG2236 Predicted phosphoribosyltransferases
--|-----------|-----|---------|----||||---|||||-||||-||||||-|-||--  2 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B)
--|-----|--||-----||||---|||||------||----|--||-||------------|---  2 [R] COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain
--|---------------||-|----|||-------------------||-----|--||||||--  2 [S] COG2326 Uncharacterized conserved protein
-||------||||-----------------------------|||||-|-----------------  2 [R] COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain
-||---||--||-||----|-|----|---------------||||--||----------------  2 [T] COG2453 Predicted protein-tyrosine phosphatase
||||--|||||||-|--|------------------------|||||-||--||||||||||||--  2 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase
--||--|||-|||-----------------------------------------------------  2 [R] COG2522 Predicted transcriptional regulator
|-|-----|--------|------------|-----------------------------------  2 [R] COG2768 Uncharacterized Fe-S center protein
--|-----|-------|-||-|--------------|-----------||-----|---||-|---  2 [T] COG2770 FOG: HAMP domain
--|-----|-------|-------------------------|||||-||||---|--|-|-----  2 [C] COG2864 Cytochrome b subunit of formate dehydrogenase
-||||||||--||-----------------------------------------------------  2 [NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella
--|---------------------------------------|||||-||||---|------||--  2 [S] COG3025 Uncharacterized conserved protein
--||||---------------------||-------------|-----|----|||---||-|---  2 [L] COG3039 Transposase and inactivated derivatives, IS5 family
--|----------------|------|----|--||------|||||-||---------|||||--  2 [R] COG3153 Predicted acetyltransferase
--||------------|--||-----|-----|-||-------|||---|-|-|||||-||-|--|  2 [S] COG3177 Uncharacterized conserved protein
--|---------------------------|----||-----|||||--|-----|------|---  2 [M] COG3209 Rhs family protein
--|----------------|----------|---|-|-----------||----------------  2 [E] COG3227 Zinc metalloprotease (elastase)
--|----------------|-------||--|--||------||||---|-----|----|||---  2 [S] COG3247 Uncharacterized conserved protein
--|-----------------------|||--------|--------|-||-|---|---|||||--  2 [R] COG3324 Predicted enzyme related to lactoylglutathione lyase
--|-||----|------|-|-------------------------|-----|------|-------  2 [S] COG3350 Uncharacterized conserved protein
|-|-||------|------------------------------------------|------|---  2 [S] COG3369 Uncharacterized conserved protein
-||-||-----|-||----|------|||-|------------------------|---|--||--  2 [G] COG3387 Glucoamylase and related glycosyl hydrolases
--|||||||---------------------------------------------------------  2 [S] COG3390 Uncharacterized protein conserved in archaea
--||||--|---------------------------------------------------------  2 [S] COG3430 Uncharacterized protein conserved in archaea
|-|||--------------|||--------||-----|--------|------|||----|||---  2 [R] COG3467 Predicted flavin-nucleotide-binding protein
--|---------------------------||-||||-----------|-----------------  2 [Q] COG3527 Alpha-acetolactate decarboxylase
--|----------------|-----------------------------|||---|------|---  2 [H] COG3585 Molybdopterin-binding protein
-||---------------|-|---------------------|||||-||-|-------|--|---  2 [L] COG3593 Predicted ATP-dependent endonuclease of the OLD family
--|-------|------|--|--------------------------------------|||||--  2 [C] COG3808 Inorganic pyrophosphatase
|||||||||||||---||||||--|-||||||||||||-||||||||-||-||--|--|||||---  2 [G] COG3839 ABC-type sugar transport systems, ATPase components
--|-----|--------|------------|-----------------------------------  2 [S] COG3875 Uncharacterized conserved protein
|||------|--------------------------------------------------------  2 [S] COG4033 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  2 [S] COG4048 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  2 [H] COG4063 Tetrahydromethanopterin S-methyltransferase, subunit A
--|---|------------------------------------------|-----|----------  2 [S] COG4273 Uncharacterized conserved protein
--||---------------|-|--------------------------|--------------|--  2 [S] COG4715 Uncharacterized conserved protein
--|-----||--------------------------------------------------------  2 [S] COG4739 Uncharacterized protein containing a ferredoxin domain
||||--------------------------------------------------------------  2 [S] COG4746 Uncharacterized protein conserved in archaea
|-|-----|---------||----------------------------------------------  2 [C] COG4802 Ferredoxin-thioredoxin reductase, catalytic subunit
--|-----------------|---------------------|||-|--------|---------|  2 [S] COG4804 Uncharacterized conserved protein
-||---||----------------------------------------------------------  2 [G] COG4809 Archaeal ADP-dependent phosphofructokinase/glucokinase
-||-----|---------------------------------------------------------  2 [S] COG4818 Predicted membrane protein
|-|-----|---------------------------------------------------------  2 [S] COG4855 Uncharacterized protein conserved in archaea
|-|-----|---------------------------------------------------------  2 [S] COG4871 Uncharacterized protein conserved in archaea
--|--------------|---------------------------|--------------------  2 [S] COG5276 Uncharacterized conserved protein
--|---------------------------------------------------------|-|---  2 [H] COG5598 Trimethylamine:corrinoid methyltransferase
--|--------|------||-----------------------------|-----|----|-----  2 [S] COG5607 Uncharacterized conserved protein
||||||--|||||-|-|-||||||--|||||---||||----|||||-||-|||||||||||||--  1 [H] COG0001 Glutamate-1-semialdehyde aminotransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase
|||||||||||||||-||||-------||||-||-|||----|--||--|--|------||-|---  1 [F] COG0005 Purine nucleoside phosphorylase
||||||--|||||||-|-||||----|||||---||||----||||||||--||||---|||||--  1 [H] COG0007 Uroporphyrinogen-III methylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||---|||||||  1 [J] COG0009 Putative translation factor (SUA5)
|||||||||||||||---||||--------|-|-|-||----|||-|-||-|||||||-||||---  1 [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0012 Predicted GTPase, probable translation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0013 Alanyl-tRNA synthetase
--|----------||-||||-|--|-||||||||-|||----|||||-||||||||--||||||--  1 [E] COG0014 Gamma-glutamyl phosphate reductase
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0015 Adenylosuccinate lyase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit
||||||||||||||||--||||--||----|||||||||||||||||||-|||-------------  1 [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0018 Arginyl-tRNA synthetase
|||||||||||||||---||----------------------|||||-||||--------------  1 [J] COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [J] COG0024 Methionine aminopeptidase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0030 Dimethyladenosine transferase (rRNA methylation)
--||||-|--|||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [E] COG0031 Cysteine synthase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase
-|||||||||-||||-|-||||----|||-||||---|----|||||-|-||-|||---|-|||--  1 [P] COG0038 Chloride channel protein EriC
||||||--|||||||-||||||||-|||||||||||||-||||||||-|-|||--|--||||||||  1 [C] COG0039 Malate/lactate dehydrogenases
||||----||||-||-||||-|----||||||--||||----|||||||||||||---||||||--  1 [E] COG0040 ATP phosphoribosyltransferase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases
|||||||||||||||-||||||----||||||||||||----|||-|--|--|--|||||||||--  1 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0048 Ribosomal protein S12
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0049 Ribosomal protein S7
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0051 Ribosomal protein S10
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0052 Ribosomal protein S2
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0054 Riboflavin synthase beta-chain
--|----------||-|||||-----||||||||||||||||||||||||||||||||||||||||  1 [C] COG0055 F0F1-type ATP synthase, beta subunit
--|----------||-|||||-----||||||||||||||||||||||||||||||||||||||||  1 [C] COG0056 F0F1-type ATP synthase, alpha subunit
-||---||--||-|--|-||||||--|||-||||--||----|||||-||||-------||-|---  1 [G] COG0058 Glucan phosphorylase
|||----|||||-|--||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EH] COG0059 Ketol-acid reductoisomerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0060 Isoleucyl-tRNA synthetase
|||||||||||||||||||||---|||||||||||||||-||||||||||||||||||||||||||  1 [G] COG0061 Predicted sugar kinase
|||||||||||||||-||||-|----|||||-----------|||||-||--|--|||||||||--  1 [S] COG0062 Uncharacterized conserved protein
||||||||||||||||||||-|----||||||--|||-----|||||-||--||||||||||||--  1 [G] COG0063 Predicted sugar kinase
||||----||-||||-||||||||||||||||||||||||||-------|---|||||||||||||  1 [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0067 Glutamate synthase domain 1
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0069 Glutamate synthase domain 2
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0070 Glutamate synthase domain 3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [R] COG0073 EMAP domain
||||||||||||||--||||-|--------||--|-||--------|-||------||-||-||--  1 [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase
||||||--||||-||-||||-|----||||||-|||||----|||-||||||||||--||||||--  1 [E] COG0077 Prephenate dehydratase
|||||||||||||||-||||-|---|||||||||||||--|-||||||||||||||--||||||--  1 [E] COG0078 Ornithine carbamoyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0080 Ribosomal protein L11
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0081 Ribosomal protein L1
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0082 Chorismate synthase
|||---||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0084 Mg-dependent DNase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0087 Ribosomal protein L3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0088 Ribosomal protein L4
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0089 Ribosomal protein L23
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0090 Ribosomal protein L2
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0091 Ribosomal protein L22
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0092 Ribosomal protein S3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0093 Ribosomal protein L14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0094 Ribosomal protein L5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0096 Ribosomal protein S8
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0097 Ribosomal protein L6P/L9E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0098 Ribosomal protein S5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0099 Ribosomal protein S13
|||||||||||--||||||||||||||||||||||||||-||||||||||||||||||||||||||  1 [J] COG0101 Pseudouridylate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0102 Ribosomal protein L13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0103 Ribosomal protein S9
|||||||||||||||||-||-||||||||||--|||||----|||||-||||||||||||||||||  1 [F] COG0105 Nucleoside diphosphate kinase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0107 Imidazoleglycerol-phosphate synthase
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase
||||||||||||||||||||-|||||||||||||||||-|||||||||||||||||||||||||||  1 [E] COG0112 Glycine/serine hydroxymethyltransferase
||||||--|||||||-|-||||||--|||||---||||----|||||-||-|||||||||||||||  1 [H] COG0113 Delta-aminolevulinic acid dehydratase
--||------|||||---|--|||--||||----||||----|||||-||||||||||||||||||  1 [C] COG0114 Fumarase
||||----|||--||-||||||----||||||||||||----|||||-||||||||||||||||||  1 [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0118 Glutamine amidotransferase
||||||||||||||||--||-|||||----||||||------||||||||||||||---|||||--  1 [G] COG0120 Ribose 5-phosphate isomerase
||||--|||||||||||-||-|------------|-||----------||---|||---|||||--  1 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0124 Histidyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||----|||||-||||||||--||||||--  1 [F] COG0127 Xanthosine triphosphate pyrophosphatase
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase
||||||||||||||||||||||||||||||||||||||||--||||||||||||||--||||||||  1 [J] COG0130 Pseudouridine synthase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0131 Imidazoleglycerol-phosphate dehydratase
||||---|||---||-|||||||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0133 Tryptophan synthase beta chain
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0134 Indole-3-glycerol phosphate synthase
||||||-||||||||-||||-||---|---||-|||||----||||||||||||||||||||||--  1 [E] COG0135 Phosphoribosylanthranilate isomerase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0136 Aspartate-semialdehyde dehydrogenase
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0137 Argininosuccinate synthase
--||||--|----||-||||||----||||||-|||||----||||||||||||||--||||||--  1 [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0139 Phosphoribosyl-AMP cyclohydrolase
||||-----|||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0141 Histidinol dehydrogenase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0143 Methionyl-tRNA synthetase
-||--|---||||||-|-||-------|----------------------------||-|||||--  1 [EQ] COG0146 N-methylhydantoinase B/acetone carboxylase, alpha subunit
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0148 Enolase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0149 Triosephosphate isomerase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0150 Phosphoribosylaminoimidazole (AIR) synthetase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||||||||||--  1 [F] COG0151 Phosphoribosylamine-glycine ligase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||||  1 [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
||||----|||||||-||||||||||||||||||||||||||---|---|---|||||||||||||  1 [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases
||||||-||||||||-||||-||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0159 Tryptophan synthase alpha chain
--||||||--|||||----|-|----|||||---|-||----|||||-|||----|---||||---  1 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0162 Tyrosyl-tRNA synthetase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase
||||||||||||||||||||||||-|||||||||||||----|||||-||||||||||||||||||  1 [L] COG0164 Ribonuclease HII
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0165 Argininosuccinate lyase
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0167 Dihydroorotate dehydrogenase
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0169 Shikimate 5-dehydrogenase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0172 Seryl-tRNA synthetase
-||||-||-||||||---||||----|||-|-----||----||||||||--||||---|||||--  1 [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes
|-||------------|||||||||||||||||||||||||||||||-||||||||||||||||||  1 [L] COG0178 Excinuclease ATPase subunit
|||||||||||||||---||-|----||||----||||----|||||-||-|-|||--||||||--  1 [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0180 Tryptophanyl-tRNA synthetase
||||||--|||||||-|-||||||--|||||---||||----||||||||-|||||||||||||||  1 [H] COG0181 Porphobilinogen deaminase
|||-|||||||||||-|||||---------------|------------|--|-------|-|---  1 [J] COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
||||||||||||||||--|-||---||||||||-||||----|||||-|||----|||-|||||||  1 [I] COG0183 Acetyl-CoA acetyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0184 Ribosomal protein S15P/S13E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0185 Ribosomal protein S19
--||||--|----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
--||||--|----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
--||||----||-||-|||||||||||||||||||||||||||||||||||||-||||||||||||  1 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0195 Transcription elongation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0197 Ribosomal protein L16/L10E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0198 Ribosomal protein L24
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0199 Ribosomal protein S14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0200 Ribosomal protein L15
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0201 Preprotein translocase subunit SecY
|||-----||---|||----||----||||||||||||-|||||||||||||||||---|||||--  1 [F] COG0207 Thymidylate synthase
|-|||||||-|||||||||-|||||-||||||||||||-|||||||||||||||||||||||||||  1 [F] COG0209 Ribonucleotide reductase, alpha subunit
-||---|||--------|---|-----||-||-||||||||||||-|-|------|---||-|---  1 [F] COG0213 Thymidine phosphorylase
|||||||||||||||--|--||----|||||--|||||------------||--------------  1 [H] COG0214 Pyridoxine biosynthesis enzyme
--|||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0215 Cysteinyl-tRNA synthetase
-|||--||||---|--||--|---------||||||||||||||||||||||||||||||||||||  1 [R] COG0218 Predicted GTPase
|-||||||-|-||||||-||||||--|||||----|-|||||||||||||||||||||||||||||  1 [C] COG0221 Inorganic pyrophosphatase
--|----------||-|||||-----||||||||||||||||||||||||||||||||||||||||  1 [C] COG0224 F0F1-type ATP synthase, gamma subunit
|-||-------|-||---||||--|-|||||||||||||||||||||-||||||||||||||||--  1 [O] COG0225 Peptide methionine sulfoxide reductase
|-||---------||---||||--|-|||-||||||||-||||||||-||||||||||||||||--  1 [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)
--|----------||-||||||||||||||||||||||--||||||||||||||||||||||||||  1 [O] COG0234 Co-chaperonin GroES (HSP10)
||||-||||||-|||-||-||------||||-||-|||-||-|||||-|||||--|||--||||||  1 [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  1 [H] COG0237 Dephospho-CoA kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0244 Ribosomal protein L10
--||-|-------|||||||||||||----|||-||||----||||||||||||||---|||||||  1 [L] COG0249 Mismatch repair ATPase (MutS family)
|||||||||||||-|-||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0250 Transcription antiterminator
|||||||||||||||-----||----||||||||||||----|||||-|||-||||||||-|----  1 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0255 Ribosomal protein L29
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0256 Ribosomal protein L18
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI)
--|----------|||-|--||||--||||||||||||||||||||||||||||||---|||||-|  1 [H] COG0262 Dihydrofolate reductase
--|----------||-||||-|--|-||||||||-|||----|||||-||||||||--||||||--  1 [E] COG0263 Glutamate 5-kinase
|-||------||-||-||||||||||||||||||||||----||||||||||||||||||||||||  1 [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
--||-------------||-||--|||||-||||||||||||||||||||||||||-|||||||||  1 [C] COG0280 Phosphotransacetylase
--|--------------|||||--|||||-||||||||||||||||||||||-||-|||-|||-||  1 [C] COG0282 Acetate kinase
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0284 Orotidine-5'-phosphate decarboxylase
||||||--|||||||-||||-|----||||||-|||||----|||||-||||||||||||||||--  1 [E] COG0287 Prephenate dehydrogenase
|||-----||------||||--||--|||-||-|||||----||||||||||||||||||||||||  1 [E] COG0289 Dihydrodipicolinate reductase
||||||--||---|||--------||----------------||||||||||||||---|||||||  1 [J] COG0293 23S rRNA methylase
--|--------|-|--|-||||||--|||----|--|-----|||||-||||---|---||-|---  1 [G] COG0296 1,4-alpha-glucan branching enzyme
|||---||||--------||----------|-----------|||-|---|-----|||-------  1 [O] COG0298 Hydrogenase maturation factor
--|----|---|-|||---||-----||||||||||||-----------|-|---|---||-||--  1 [R] COG0300 Short-chain dehydrogenases of various substrate specificities
|||||||||||||----|------|-----|||||||||||||||||-||||--------------  1 [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase
||||||||||||-|---|-|-|||--|||||---||||----||||||||||-||||||||-|---  1 [P] COG0306 Phosphate/sulphate permeases
--|-||----||-|||--||-|----||||-|||--------|||||-||||||||---|||||--  1 [E] COG0308 Aminopeptidase N
|||||||||||||---|-||----------|-----------|||-|---------|||-------  1 [O] COG0309 Hydrogenase maturation factor
|||||||||||||||--|---|----|||||--|||||------------||--------------  1 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis
|||||||||-|||---|-||-|----|||-----||||----|||||-||||---|||||||||--  1 [H] COG0314 Molybdopterin converting factor, large subunit
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [H] COG0315 Molybdenum cofactor biosynthesis enzyme
--|----------||-|-||-|----||||----|-||----||||||||||||||---|||||||  1 [S] COG0316 Uncharacterized conserved protein
|-||------------|||||||||||||||||||||||||||||||-||||||||||||||||||  1 [L] COG0322 Nuclease subunit of the excinuclease complex
--||---------|||||||||||||----||||||||----||||||||||||||---|||||||  1 [L] COG0323 DNA mismatch repair enzyme (predicted ATPase)
--|----------||-||||||----||||||||||||----||||||||||||||||||||||--  1 [R] COG0325 Predicted enzyme with a TIM-barrel fold
||||--||||---|||---|||||||||-|||||||||||--||||||||||-||||||-------  1 [S] COG0327 Uncharacterized conserved protein
|||||||||||||---|||||-||--||||||||||||----||||||||||||||||||||||||  1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase
|||||||||||||||-||||||--||||||||||---|-|--||||||||||||||||||||||||  1 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs
--|||||||-|||||--|||||||--|---|--|||||----|||||--|||-|||||--||-|--  1 [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase
||||--|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||||  1 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0341 Preprotein translocase subunit SecF
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0342 Preprotein translocase subunit SecD
|||||||||||||-||||||||||-||---||||||||----||||||||||||||||||||||||  1 [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase
|-|-||----|||||-||||-|--|-||||||||||||----|||||-||||||||||||||||--  1 [E] COG0345 Pyrroline-5-carboxylate reductase
-||-||--||-|------||----------|-----------|||-|-||||-|||||||||||--  1 [C] COG0348 Polyferredoxin
||||||||||||||--||-||-|||-||||||-|||||-|--|||||-||||||||||||||||-|  1 [L] COG0350 Methylated DNA-protein cysteine methyltransferase
|||||||||||||||-||-|||--|-||||||||||||----|||||-||||||||||||||||--  1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
--|-|||||----||-|-||||----||||||-|||||----|||||-||||||||||||||||--  1 [H] COG0352 Thiamine monophosphate synthase
--|----------||-|||||-----||||||||||||||||||||||||||||||||||||||||  1 [C] COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit)
--|----------|--|||||-----||||||||||||||||||||||||||||||||||||||||  1 [C] COG0356 F0F1-type ATP synthase, subunit a
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0358 DNA primase (bacterial type)
|-||||--|-|||||||-||-|-----||--|--||||----|||||-||-||--||-||||||--  1 [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases
--|-||----|--||--|||-|----|||-||||||||-|--|||||-||-----|---||-||--  1 [G] COG0366 Glycosidases
|||||||||||||-----||||----|||-|----|-|----|||-|-||-----|---||||---  1 [H] COG0368 Cobalamin-5-phosphate synthase
|||||||||||||-|--|||----------||||-|||----|||||-------------|-----  1 [C] COG0371 Glycerol dehydrogenase and related enzymes
|-||||--|-|||||-||||-|----||||-|--||||----|||||-||-|||||||||||||||  1 [C] COG0372 Citrate synthase
||||||--|||||---|-||||||--|||||---||||----|||||-||-||||||||-------  1 [H] COG0373 Glutamyl-tRNA reductase
|||---||||------|-||-|--------------------|||-|---------|||-------  1 [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)
--||----|----|----|--------||--------|----|||||-|---|--|---||-||--  1 [P] COG0376 Catalase (peroxidase I)
--|||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases
--||---------||---||||----|||-|----|||----|||-|-||-|---|---|||||--  1 [R] COG0384 Predicted epimerase, PhzC/PhzF homolog
-||-------------||||-------||-----|-|-----|||-|--------|----------  1 [R] COG0390 ABC-type uncharacterized transport system, permease component
||||----||---|--||||-|----||||||||||||----|||||-|--|--------------  1 [S] COG0391 Uncharacterized conserved protein
|||||||||--|-----|||-------|||-|---|-|----|||-|-|--|-----------|--  1 [S] COG0393 Uncharacterized conserved protein
|-||----|----||-|-||-|----|||-||||||||----|||-|-||-|||||--||||||--  1 [T] COG0394 Protein-tyrosine-phosphatase
--||---------||---||------|||-||||||||----|||---|-----------|--|--  1 [S] COG0398 Uncharacterized conserved protein
--|-||-----|-||-||||||----||||||||||||----|||||-||-||--|---|||||--  1 [G] COG0406 Fructose-2,6-bisphosphatase
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0409 Hydrogenase maturation factor
--|-|------|-||-|-||-------|||------|-----|||||--|-----|---||-||--  1 [Q] COG0412 Dienelactone hydrolase and related enzymes
|-||-------|-|----||------|-----|-||------||||||||----|----|--||--  1 [L] COG0415 Deoxyribodipyrimidine photolyase
||||||||||||||||---|----------------------|||||-||----------------  1 [L] COG0417 DNA polymerase elongation subunit (family B)
||||||||||||||||||||||--||----||--|||-----|||||-||----------------  1 [L] COG0419 ATPase involved in DNA repair
||||||||||||||||-----|--|||||||---|---||||------------------------  1 [J] COG0423 Glycyl-tRNA synthetase (class II)
--|---||-----||-||||||||--|||||-----||----|||||-||-|||||||||||||||  1 [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation
||||||--||||----|||||-------------|-|-----||||||||||-|||--||||||--  1 [O] COG0425 Predicted redox protein, regulator of disulfide bond formation
||||--|||||||||||--|----------------------|||-|--|-----|----------  1 [A] COG0430 RNA 3'-terminal phosphate cyclase
--||---||-|||---|-------------------------|||||-||||---|--|-|-|---  1 [C] COG0437 Fe-S-cluster-containing hydrogenase components 1
|||-----|--|-||-|-||-||||--||-||||||||----|||||-||||||||||||||||--  1 [I] COG0439 Biotin carboxylase
|||---||||--|||-||||-|----||||||-|||||----||||||||||-|||--||||||--  1 [E] COG0440 Acetolactate synthase, small (regulatory) subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0441 Threonyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0442 Prolyl-tRNA synthetase
|||||||||||||||-||||||--|||||-||||||-|-||||||||-||-|---|---|||||--  1 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases
||||||||-||||||||||||||||-||||||||||||----||||||||||||||||||||||--  1 [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
|||-|||||-|||||||||||||||--|||-||-||||----||||||||-||--|||||||||||  1 [O] COG0450 Peroxiredoxin
|||||||||||||||-||||||---|||||||||||||----|||||-||||||||||||||||--  1 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0460 Homoserine dehydrogenase
|||||||||||||||-||||||-|--||||||||||||----||||||||||||||||||||||--  1 [F] COG0461 Orotate phosphoribosyltransferase
|||||||||||||||-||||||--||||||||||||||||||||||||||||||||||||||||-|  1 [FE] COG0462 Phosphoribosylpyrophosphate synthetase
--|----------||-||--||||||----|-----||||||||||||||||||||||||||||||  1 [O] COG0466 ATP-dependent Lon protease, bacterial type
-|||||||--||||||-|||||||-|||||||||||||||||||||||||||||||--||||||--  1 [G] COG0469 Pyruvate kinase
|-|||||||-|||||||-||||----|||||--|||||----|||||-||||||||||||||||--  1 [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
-|||--||||||||||--------------------------------------------------  1 [T] COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0480 Translation elongation factors (GTPases)
||||--||||||||--||||-|---|||||-|||||||----|-||||||||||||--||||||||  1 [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
||||||||||||||||||||||----|||||--|||||----|||||-||||||||||||||||||  1 [D] COG0489 ATPases involved in chromosome partitioning
||||||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0492 Thioredoxin reductase
--|-||||--|-|||||||--|--|-||||||--||||----|||||-||--|--|--||||||||  1 [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0495 Leucyl-tRNA synthetase
||||----|||-||--||||-||||-----------------|||||-||||||||||||||||--  1 [R] COG0496 Predicted acid phosphatase
|||||||||||||||-||||------||||-------------------|--|--|---|||||--  1 [H] COG0499 S-adenosylhomocysteine hydrolase
|||------|---||-|||||--|--|||||---|-||----||||||||||||||||||-|||--  1 [H] COG0502 Biotin synthase and related enzymes
||||--||-||||||--|||||--|||||-||||||||||||||||||||||-||||||||||---  1 [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
||||||||||||||||||||-|||||||||||||||||||--||||||||||||||||||||||||  1 [F] COG0504 CTP synthase (UTP-ammonia lyase)
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  1 [EF] COG0505 Carbamoylphosphate synthase small subunit
|||---|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||--  1 [I] COG0511 Biotin carboxyl carrier protein
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II
|||-||--|--|-||||-||||--|-||||||||||||||||||||||||||||||||-|||||||  1 [LKJ] COG0513 Superfamily II DNA and RNA helicases
--|---------||||--||||--|-|---||--||||----|||||-||||||||---||-||--  1 [L] COG0514 Superfamily II DNA helicase
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0519 GMP synthase, PP-ATPase domain/subunit
|||||||||||||---|--|-|----|||||---||||----|||||-||||---|||||||||--  1 [H] COG0521 Molybdopterin biosynthesis enzymes
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0522 Ribosomal protein S4 and related proteins
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0525 Valyl-tRNA synthetase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0527 Aspartokinases
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0528 Uridylate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0532 Translation initiation factor 2 (IF-2; GTPase)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0533 Metal-dependent proteases with possible chaperone activity
|||||||||-|||||||-||||||-|||||||||||||||||||||||||||||||||||||||||  1 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
|||||||||||||||-||||||----||||||||||||----||||||||--||||||||||||--  1 [F] COG0540 Aspartate carbamoyltransferase, catalytic chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0541 Signal recognition particle GTPase
|-||--|||----|--|-||-|--|||||-|||||||||---|||||-||||||||||||||||--  1 [R] COG0546 Predicted phosphatases
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0547 Anthranilate phosphoribosyltransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||-|  1 [E] COG0548 Acetylglutamate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0552 Signal recognition particle GTPase
--||-||||--|||||-|||||||--|||-||||-|||--|||||||-|||||-------|-----  1 [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
|-||------------|||||||||||||||||||||||||||||||-||||||||||||||||||  1 [L] COG0556 Helicase subunit of the DNA excision repair complex
|||||||||||-|||-----|--|--||||||----------|||||-||||||||||||||||--  1 [E] COG0560 Phosphoserine phosphatase
--||--|||----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0563 Adenylate kinase and related kinases
||||||--||-||-----||-|--------------------|||||-||||||||---|||||-|  1 [J] COG0565 rRNA methylase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [I] COG0575 CDP-diglyceride synthetase
|-||||-------||-||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0576 Molecular chaperone GrpE (heat shock protein)
|||||||||||||||||----|--------------------|||||-||||----|||-------  1 [S] COG0585 Uncharacterized conserved protein
--|----------||-----|-||||||||||||||------||||||--||||||----||||--  1 [G] COG0588 Phosphoglycerate mutase 1
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
||||--||-|-------|||||----||||||||||||||||--------------||||||||||  1 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily
-||---|-|-||-||-||||||----|||||||||||-----|||||-|||||--|||||||||-|  1 [P] COG0598 Mg2+ and Co2+ transporters
-||-----||-------|||||||--|---|--||-||----||||---|||---|---|||||--  1 [P] COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
||||||||||||----|-|||---------||||||||----|||||-||||||||||||||||||  1 [O] COG0602 Organic radical activating enzymes
|||||||||||||---|-||----------|---|-||----|||||-||||||||||||||||||  1 [R] COG0603 Predicted PP-loop superfamily ATPase
|-||||----|||||||-||-|||-|||||||||||||----||||||||||||||||||||||||  1 [P] COG0605 Superoxide dismutase
||||---||----------|-----------||-||--|||-------||||||--|||-||-|-|  1 [V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
|||||||||||||---|-||------||||------||----||||||||||||||--|----|--  1 [H] COG0611 Thiamine monophosphate kinase
|||||||||||||||||--------------|--|||----------------------------|  1 [MI] COG0615 Cytidylyltransferase
|||||||||||||---||||||-||-|||||---|-||----||||||||||||||||||||||||  1 [J] COG0621 2-methylthioadenine synthetase
--||||||--|||||--|--||----||||||||||||----|||||-||||||||||||||||--  1 [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases
||||||||--||||||||----||---||||---|||||||||||||||-----------------  1 [L] COG0648 Endonuclease IV
--|||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7
|||--|||-|-|-----|---------||-------------|||-|-------------------  1 [C] COG0650 Formate hydrogenlyase subunit 4
|-||---------|||--||||--|-||||||||||||----|||||-||||||||||||||||--  1 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
--|--|--|--|-||--|||-|--|-|||||||-||-|----|||||-||--|--|---||-||--  1 [I] COG0657 Esterase/lipase
--|----------||||-||--||--||||-|---|||----|||-|-||-|---|||-||-|---  1 [P] COG0659 Sulfate permease and related transporters (MFS superfamily)
--|||||||-|||||-|-||-|||-|||||||||-|||----|||||-||||||||||||||||--  1 [E] COG0665 Glycine/D-amino acid oxidases (deaminating)
|-||||||-|||-||-||||-|----|---||||||||----|||||-||-|---|||||||||--  1 [R] COG0673 Predicted dehydrogenases and related proteins
||||||||||||||||||||||||||||||||||||||-|--||||||||||||||||||||||||  1 [U] COG0681 Signal peptidase I
|||-----||---|-------|----||||-------|----|||||-||||---|---||-|---  1 [H] COG0684 Demethylmenaquinone methyltransferase
--|-||||--|||||-||||-|----|---||-|||||----||||||||||||||--||||||--  1 [E] COG0685 5,10-methylenetetrahydrofolate reductase
||||----||---||-----||||---||||-----||----|||||-|||||||||||||||-||  1 [I] COG0688 Phosphatidylserine decarboxylase
|-||----|----|||-|||-|----|||||||||||-----|||||-||||||||---|||||||  1 [O] COG0695 Glutaredoxin and related proteins
--|----------||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0703 Shikimate kinase
-||||-|||||||||-||||-|--|-||||||||||||----|||||-|||||--|--||||||--  1 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
--|------|-|----||||||||||||||||||||||----||||||||||||||||||||||||  1 [M] COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase
|-|-||--|--|-|||--||||--|||||-||||-||-----|||||-||||||||||||||||||  1 [L] COG0708 Exonuclease III
||||||-|||||-||-|-----||-------||||||-----|||-|------||-----------  1 [E] COG0710 3-dehydroquinate dehydratase
--|-------------|||||-----||||||||||||||||||||||||||||||||||||||||  1 [C] COG0711 F0F1-type ATP synthase, subunit b
--||||------|---|-||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)
-||-----||---||--|||||||--|---|--||-||----||||--||||---|---|||||--  1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
|||||||||||||---|-||--||--|||||------|----||||||-|||||||||||||||||  1 [F] COG0717 Deoxycytidine deaminase
||||----||-||---||||||||||||||||||||||--||-------|---|||||||||||||  1 [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit
--||||----|||||-|-||-|----|||||-----||----------||--||||||||||||||  1 [C] COG0723 Rieske Fe-S protein
|||||||||||||---|-||-|----|||-----||||----|||||-||||--||||||||||--  1 [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A
--|-----|-|-|---|-||-|----||||----|-||----|||||-||||||||||||||||||  1 [O] COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component
--|-----|-|-|----|||||||--|---||||||||----|||||-|||--|||||||||||||  1 [E] COG0765 ABC-type amino acid transport system, permease component
|||------|------||||||||||||||||||||||----||||||||||||||||||||||||  1 [M] COG0770 UDP-N-acetylmuramyl pentapeptide synthase
|||---|||||||---|---|-||------|---|||-----|||||-||||||||||||||||||  1 [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation
|-|---|-|----|---|||------|||-|----||--------------|--|----|------  1 [P] COG0798 Arsenite efflux pump ACR3 and related permeases
|-||--|||-|-|---|||||||||-||||||||||||-------||--|||-||---|||-|-||  1 [P] COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
|-||||----|||---|-||||--|-|||-|---||||----|||||-||||||||||||||||--  1 [R] COG0824 Predicted thioesterase
--||--|||-------||||-|--------|-----------|||||-||--|---||-|||||-|  1 [M] COG0836 Mannose-1-phosphate guanylyltransferase
--||||--|-|||---|-||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A)
--|-------------||||||---|----|---|-||----|||||-||||||||||||||||||  1 [V] COG0841 Cation/multidrug efflux pump
--|||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit
--|---------------||-|-----||||------|----|||||-||--||||||||||||--  1 [P] COG0855 Polyphosphate kinase
|||-----||-----------|---|----|----|||----|||--------------||||---  1 [F] COG1001 Adenine deaminase
-|||||----|----------|---||---|-----|-|----||-|---|---|-|||----|--  1 [V] COG1002 Type II restriction enzyme, methylase subunits
-|||---||--|----|-||------|||---|---||----|||||-||-||--|--||||||||  1 [M] COG1004 Predicted UDP-glucose 6-dehydrogenase
--||||--|-|||---|-||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H)
||||--||---------|||-|----|-------||||----------||---------|||--||  1 [P] COG1006 Multisubunit Na+/H+ antiporter, MnhC subunit
--||||--|-|||---|-||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N)
--||||----------|-||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M)
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG1010 Precorrin-3B methylase
|||||||||||--||---------------------------------------------------  1 [R] COG1019 Predicted nucleotidyltransferase
--|-|||||-|-|---|-----------------|-||-----------|-----|----|-|---  1 [O] COG1030 Membrane-bound serine protease (ClpP class)
-|||--|||||-|----|------------------------------------------------  1 [C] COG1031 Uncharacterized Fe-S oxidoreductase
|||||||||||||||---------------------------------------------------  1 [L] COG1041 Predicted DNA modification methylase
--||||----|||||-|----|----||||||--|||-----|||||-||--||||---|||||||  1 [C] COG1048 Aconitase A
|||---|||||||---|-||-|----||||||-|-|||-------|--||-----|---|||||-|  1 [F] COG1051 ADP-ribose pyrophosphatase
|||||||||-|||-----|--|-----||--|----------|||||---||---|----------  1 [H] COG1056 Nicotinamide mononucleotide adenylyltransferase
--|-||----|||||---||------||||-||||-||----|||-|--|--|||||||||||---  1 [R] COG1064 Zn-dependent alcohol dehydrogenases
||||||||||-------|------|-----|-----||----|||||-||||--------------  1 [O] COG1067 Predicted ATP-dependent protease
|||||||||||||--|||--|----------||||||||-||------------------------  1 [R] COG1078 HD superfamily phosphohydrolases
--|---------------|-------------------------------||-|--|-|-------  1 [M] COG1083 CMP-N-acetylneuraminic acid synthetase
||||||||||||||||--------------------------------------------------  1 [R] COG1084 Predicted GTPase
--|---|-|-|--||--|--------||--||----------|||||-|-||--------------  1 [C] COG1085 Galactose-1-phosphate uridylyltransferase
|-||-||||--||---|-||||----|||||||---||----|---|--|--||||---||-||||  1 [M] COG1091 dTDP-4-dehydrorhamnose reductase
||||||||||||||||--------------------------------------------------  1 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)
||||||||||||||||--------------------------------------------------  1 [R] COG1094 Predicted RNA-binding protein (contains KH domains)
||||||||||||||||--------------------------------------------------  1 [K] COG1095 DNA-directed RNA polymerase, subunit E'
|-|-|||||||||||---------------------------------------------------  1 [J] COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain)
|-|-||||||||||||--------------------------------------------------  1 [J] COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)
|||||||||||||-----------||----------------------------------------  1 [F] COG1102 Cytidylate kinase
|||-----||--------------------------------------------------------  1 [R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes
||||--||||--------------------------------------------------------  1 [L] COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain
|-||--|||-|-|---|||||||||-||-|||||||||----||||||||||-||---|||||-||  1 [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
||||||||||---||---------------------------------------------------  1 [L] COG1111 ERCC4-like helicases
|||||-||||-|-||||||-|------||||---|---|||||||-|--|--|---|--------|  1 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits
--|---||------------|||||-|-----|||-||----|||-|-||||-||-|||-||----  1 [E] COG1115 Na+/alanine symporter
-||-||--||||-----|||||||--|---|--||-||----||||---||||--|---|||||--  1 [P] COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG1117 ABC-type phosphate transport system, ATPase component
--|----------||------|----||||-|--||||----|||||----|--------------  1 [P] COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA
|-||--|||-|||---|||||||||-|--|||||||||----||||||||||-||---|||||-||  1 [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component
--|--|--------------|-||--------|-|--|||--|||||------------||||---  1 [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
--|-----|-------|-||------|||||||-||||--------|-||-||||---|-||||||  1 [GM] COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component
--|-----|-|-|--------|--------------------|||||-|||||------|||||||  1 [O] COG1138 Cytochrome c biogenesis factor
|||---||||-------|||----------------------|||||-------------------  1 [C] COG1142 Fe-S-cluster-containing hydrogenase components 2
|||||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)
|||-||||||||----||--------------------------------------||--------  1 [C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B
-||---||-|||||||-||||----|----||||||||||||------|----||-----------  1 [R] COG1161 Predicted GTPases
--|-------------|||||----||||||||||||||||||||||-||||||||------|---  1 [R] COG1162 Predicted GTPases
||||||||||||||||--------------------------------------------------  1 [R] COG1163 Predicted GTPase
--|-------------||||||||||||||||||||||----|||||-||||||||||||||||||  1 [M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes
||||----||---||-----|-||-|-||||-----||-----------|--|||||||||||-||  1 [I] COG1183 Phosphatidylserine synthase
-||||||||-|-|||--|------------------------------------------------  1 [J] COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
--|-----|-------|||||----|||||||||-|||||----------------||||||||||  1 [J] COG1189 Predicted rRNA methylase
--|-------||-|||||||||||--|||||||||||||||||||||||||||||||||||-----  1 [J] COG1190 Lysyl-tRNA synthetase (class II)
|-||--||--------||||||---|----||||||||------------------|||-------  1 [L] COG1193 Mismatch repair ATPase (MutS family)
-||||||||----|||||||||--||||||||||||||||||-------|--|||----|||||--  1 [D] COG1196 Chromosome segregation ATPases
|||||||||||||------|------|||-------------|||----|-----|---|||||--  1 [R] COG1201 Lhr-like helicases
||||--||-|--------------------------------------------------------  1 [R] COG1202 Superfamily II helicase, archaea-specific
|||---|||-|||---||--|-----------|----|----|||||----|--------------  1 [R] COG1203 Predicted helicases
|||||||||||||||||-------------------------|----------------||-----  1 [R] COG1204 Superfamily II helicase
|||---||||||-||----|-|----|||-------||-----||---------------|-----  1 [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
|||----|---|----|--||----|||||||||||||--|||||||-||||||||||||||||--  1 [M] COG1210 UDP-glucose pyrophosphorylase
|-|-||||||||-||||-||------|---|||-||||----|||||--|-----|---|||||-|  1 [M] COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
|||-----||--------------------------------------------------------  1 [R] COG1223 Predicted ATPase (AAA+ superfamily)
--|---|---||-|||||-|-|----|--||||||||-----|||||--|-|||||--||||||--  1 [P] COG1230 Co/Zn/Cd efflux system component
--||--|-|-|--||-|----|||--||||----||||-------|---------|-------|--  1 [H] COG1232 Protoporphyrinogen oxidase
||||||||||----|-|-|||-||||----||||||||----||||---|-----|---|||||||  1 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
-||------|------|-------------------------|||||-||||||||--||||||||  1 [S] COG1238 Predicted membrane protein
||||||--||--------||-|----|||--------------------|-----|----------  1 [H] COG1239 Mg-chelatase subunit ChlI
||||||---|--------||------|||--------------------|-----|----------  1 [H] COG1240 Mg-chelatase subunit ChlD
||||||||||||-|||-|--|---------|-----------------------------------  1 [KB] COG1243 Histone acetyltransferase
||||||||||--------------------|-----------------------------------  1 [R] COG1244 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
--|-------|-|-----||-|----|---||-|||||----|||-|-||-----|---|||||--  1 [M] COG1247 Sortase and related acyltransferases
--||---------||-|||||||||||||-|||||||-||||||||||||||||||||||||||||  1 [R] COG1253 Hemolysins and related proteins containing CBS domains
-||-|||||-|||----|-|-|---|--|-||||||||----|||||-||-|---|----|-|---  1 [C] COG1254 Acylphosphatases
||||||||||||||||---------|-----|||||------------|-----------------  1 [I] COG1257 Hydroxymethylglutaryl-CoA reductase
|||||||||||||--|--------------------------------------------------  1 [J] COG1258 Predicted pseudouridylate synthase
--||----|-|||---||||--||--||||------------------------------------  1 [S] COG1259 Uncharacterized conserved protein
|||---||-||-|---|---|-----------|--|||----|||||-||||-||||||-----||  1 [I] COG1267 Phosphatidylglycerophosphatase A and related proteins
|-||--|||--------||||||-|-|---||||||||---------------------||||-||  1 [R] COG1268 Uncharacterized conserved protein
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I
|||||||||||||-----||||-----||-|----|-|--------|-||-----|---||||---  1 [H] COG1270 Cobalamin biosynthesis protein CobD/CbiB
--||||--|-------|-||--||--|||--|--||||----|||||-||||---|--||||||||  1 [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1
||||||||||||||||-|||||---|----||||||||------------------|||-------  1 [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP
--||------------|-||--||--|||--|--||||----|||||-||||---|--||||||||  1 [C] COG1294 Cytochrome bd-type quinol oxidase, subunit 2
--|-------------|-||||||--||||||||||||-|--|||||-||||||||||||||||||  1 [S] COG1295 Predicted membrane protein
--|-----|-----------||----|----|-|||||----|||||-||||-|||||-||||---  1 [E] COG1296 Predicted branched-chain amino acid permease (azaleucine resistance)
|||---||||--|-----||-------||-|---|-||-----------|------------||--  1 [S] COG1300 Uncharacterized membrane protein
||||||||||-||-----------------------------------------------------  1 [S] COG1303 Uncharacterized protein conserved in archaea
|||||||||||||||---||-|--||||||-||||||-----|||||-||||-||----|||||||  1 [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
|||||||||||-||||--------------------------------------------------  1 [K] COG1308 Transcription factor homologous to NACalpha-BTF3
|-|||||||||||||||-||-|-----||--------------||||--|-----|----------  1 [R] COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily
||||||||||---|||--------------------------------------------------  1 [L] COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
|||---|||||-|---||------------|-----------------------------------  1 [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins
||||--||---------|---|----|-------||||----------||---------|||--||  1 [P] COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit
|-|-|||||||-|--|||-|-|-|------------------|||||-----|--|--------||  1 [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations
||||--|||||||-----------------------------------------------------  1 [J] COG1325 Predicted exosome subunit
|||---||-|-------|--|---------||||||------|||||-||||---|----------  1 [F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase
|-||||--|-|||---|--|-|||---||-|-----|------------------------||---  1 [O] COG1331 Highly conserved protein containing a thioredoxin domain
|||--||----------|---------||-------------------------------------  1 [L] COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||--||--|||-----|-|-------||-------------------------------------  1 [L] COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||||||||||||-----------------------------------------------------  1 [KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon
|||--|--||||-----|-||------||---|----|----------------------------  1 [L] COG1343 Uncharacterized protein predicted to be involved in DNA repair
--|---||------------||--------||--|-||----|||||-||||-|||-----|----  1 [M] COG1346 Putative effector of murein hydrolase
|-|-|||||-|||---||------------------------------------------------  1 [R] COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)
-||||||||-------||||||--|-||||||||||||||||-------|--||||---|||||--  1 [S] COG1354 Uncharacterized conserved protein
|||-|||||||||||-||--------------------------------------------|---  1 [R] COG1355 Predicted dioxygenase
||||||||||||||||-|--|---------||||||||----------------------------  1 [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a)
--||--------------|-||----|||-||-|-||-----|||||-||-|-|||---||-||--  1 [S] COG1359 Uncharacterized conserved protein
||||--|||||-|----|-|||--------||||||||||--|||-|--|----------|-----  1 [G] COG1363 Cellulase M and related proteins
|||-----||---||-||||-|----||||||--||||-----------|---|||---|||||--  1 [E] COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase)
||||--||||-||||---------------------------------------------------  1 [J] COG1369 RNase P/RNase MRP subunit POP5
|||||||||||||-----------------------------------------------------  1 [O] COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit
|||||||||||||---||---------||-------------------------------------  1 [S] COG1371 Uncharacterized conserved protein
|||---||-|--------------------------||----------------------------  1 [S] COG1379 Uncharacterized conserved protein
--|---||------------||--------||--|-||----|||||-||||-|||-----|----  1 [R] COG1380 Putative effector of murein hydrolase LrgA
|||||||||||||||---------------------------------------------------  1 [O] COG1382 Prefoldin, chaperonin cofactor
||||||||||||||||--------------------------------------------------  1 [J] COG1383 Ribosomal protein S17E
||||||||||--|-----------||-----------------------------------|||||  1 [J] COG1384 Lysyl-tRNA synthetase (class I)
--|-|||||--------|||||--|-||||||||||||||||-------|--||||---|||||--  1 [K] COG1386 Predicted transcriptional regulator containing the HTH domain
||||--|||||||-----------------------------------------------------  1 [L] COG1389 DNA topoisomerase VI, subunit B
|||||||||||-||||----||||||----------------------------------------  1 [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E
|||---|||--|-----|---|||------|---|||-----------||||---|---||-|---  1 [P] COG1392 Phosphate transport regulator (distant homolog of PhoU)
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D
|||||||||||||-----------------------------------------------------  1 [K] COG1395 Predicted transcriptional regulator
-||-----|-------|--|-|--------|--|--------|||-|---------------|---  1 [O] COG1397 ADP-ribosylglycohydrolase
||||||||||||||||--------------------------------------------------  1 [U] COG1400 Signal recognition particle 19 kDa protein
|-|---|---||----|-|--|-----------|--|-----|--|----------|||-------  1 [V] COG1401 GTPase subunit of restriction endonuclease
||||||||||||||||--------------------------------------------------  1 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
|||||||||||||----------------------------------------------|||||--  1 [R] COG1407 Predicted ICC-like phosphoesterases
|-|-------|-----|--|-|||--||||||---|||----|------------||||-|-|---  1 [R] COG1408 Predicted phosphohydrolases
|||-----||--------------------------------------------------------  1 [R] COG1411 Uncharacterized protein related to proFAR isomerase (HisA)
||||||||||||||||--------------------------------------------------  1 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
||||||||||--------------------------------------------------------  1 [S] COG1422 Predicted membrane protein
|||---||||--|---|-------------------------------------------------  1 [L] COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III
||||--||||------|-||-|--|-|---------------------||----|-||||||||--  1 [S] COG1432 Uncharacterized conserved protein
||||||||||||||||----||--|--------|--------------------------------  1 [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F
||||--|||||||------------|----|--------------|---------|----------  1 [F] COG1437 Adenylate cyclase, class 2 (thermophilic)
||||||||||||||||--------------------------------------------------  1 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
|-|||||||--||||-||--|-----|---||-|||||----|||||-||-|---|---||||---  1 [C] COG1454 Alcohol dehydrogenase, class IV
|||---||||--|---|-------------------------------------------------  1 [R] COG1458 Predicted DNA-binding protein containing PIN domain
|||||||||||||-----------------------------------------------------  1 [S] COG1460 DNA-directed RNA polymerase, subunit F
||||----||------|-------------------------------------------------  1 [E] COG1465 Predicted alternative 3-dehydroquinate synthase
||||||||||||||||--------------------------------------------------  1 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit
|||---|||-|||---||-||-----------|----|----------------------------  1 [L] COG1468 RecB family exonuclease
||||||||||--|----|----------------|-||-----------|--||||----------  1 [S] COG1469 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1471 Ribosomal protein S4E
--||||||---|-----|||||----|||-||-|||||----|||----|||---|--||||||--  1 [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase
--|-------------||--|||||-----||||-|------|||||-||||||||----||||--  1 [H] COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis
-|||--|----------|-||-----|---|----|--||---|||--|--|--|-|||-------  1 [S] COG1479 Uncharacterized conserved protein
--|||||||||||||-||||||--|||||-||||||||||||||||||||-|||||--|||||---  1 [H] COG1488 Nicotinic acid phosphoribosyltransferase
|||||||||||||-----------------------------------------------------  1 [J] COG1491 Predicted RNA-binding protein
||||||--||-|------||||-----||-|----|-|--------|-||-----|---|||||--  1 [H] COG1492 Cobyric acid synthase
--|---------------||||----|||||-----||----|||-|-|-||---------|||--  1 [G] COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins
||||||--||--------------------------------------------------------  1 [K] COG1497 Predicted transcriptional regulator
||||||||||||||||--------------------------------------------------  1 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog
||||||||||||||||--------------------------------------------------  1 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay
||||||||||||||||--------------------------------------------------  1 [J] COG1500 Predicted exosome subunit
-||-------------||--||--|-----------||----|||||-|-|||------||-||--  1 [E] COG1509 Lysine 2,3-aminomutase
|||-|||||||||---||-|-|----|---|---|-||----|||||--|-----|---|||||--  1 [J] COG1514 2'-5' RNA ligase
|||-|||-|||||---||-||------||---|--|-|----|||||----|--|---|-------  1 [L] COG1518 Uncharacterized protein predicted to be involved in DNA repair
--|--------|-----||-||||--|||-|-||--||-|--|||||-||||---|---||-|---  1 [G] COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
|||-||--|-||--------------|||-----||||----|||||-||||---|--||||||--  1 [C] COG1526 Uncharacterized protein required for formate dehydrogenase activity
|||||||||||--|||----||----------||--------------------------------  1 [C] COG1527 Archaeal/vacuolar-type H+-ATPase subunit C
|-|-----|------|-|--------|||-|---|--||---|||||-|-||----|||-------  1 [P] COG1528 Ferritin-like protein
-||-|-|||||||----||-|------||-|-----||-----------|-----|---|||||-|  1 [L] COG1533 DNA repair photolyase
||||--||||-||-------|---------||||||||----|||||-||||||||----------  1 [J] COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
||||||||||||||||--------------------------------------------------  1 [R] COG1537 Predicted RNA-binding proteins
|||||||||||||--------------||----------------------------------|--  1 [R] COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon
|||-----||--------------------------------------------------------  1 [KG] COG1548 Predicted transcriptional regulator/sugar kinase
||||||||||||||||--------------------------------------------------  1 [J] COG1552 Ribosomal protein L40E
|||------|-------|------------------------||||||||||--------------  1 [P] COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction
--|--------------|||||----|||-||||||||----|||||-||||||||--|-------  1 [L] COG1555 DNA uptake protein and related DNA-binding proteins
|||--||----------|---------||-------------------------------------  1 [L] COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
||||--||||||||||---------|-----|||||------------------------------  1 [I] COG1577 Mevalonate kinase
|||---|||||-----||------------------------------------------------  1 [S] COG1578 Uncharacterized conserved protein
|||--||||-------||------------------------------------------------  1 [L] COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
||||||--||||-||-|-||||||--|||||---||||----|||||-||-||||||||||||---  1 [H] COG1587 Uroporphyrinogen-III synthase
||||||||||--|-----------------------------------------------------  1 [J] COG1588 RNase P/RNase MRP subunit p29
|||||||||-||||||--------------------------------------------------  1 [K] COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS
||||||||||||||||--------------------------------------------------  1 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain
|-|||||||||||-----------------------------------------------------  1 [S] COG1602 Uncharacterized conserved protein
||||--||||-||||---------------------------------------------------  1 [J] COG1603 RNase P/RNase MRP subunit p30
||||||--|||||||-||--||----||||||||||||----||||||||||||||||||||||--  1 [E] COG1605 Chorismate mutase
|||-----||-------|||----------|-----------------------------------  1 [R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily
|||||||||||||-----------------------------------------------------  1 [R] COG1608 Predicted archaeal kinase
--|-||||||||-|--||-|||||--||||-|--|-||----|||||-||-|||||--||||||--  1 [R] COG1611 Predicted Rossmann fold nucleotide-binding protein
|||---||||--------------------------------------------------------  1 [S] COG1617 Uncharacterized conserved protein
|||-|||||||||---||------------------------------------------------  1 [F] COG1618 Predicted nucleotide kinase
-|||--||||------|-||-|||||----||||||||-|||------------------------  1 [S] COG1624 Uncharacterized conserved protein
|||---||-|--------||-|--------|-----------------------------------  1 [C] COG1625 Fe-S oxidoreductase, related to NifB/MoaA family
|||||||||||||--------|--------------------------------------------  1 [S] COG1628 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1631 Ribosomal protein L44E
||||||||||||||||--------------------------------------------------  1 [J] COG1632 Ribosomal protein L15E
|||||||||||||-----------------------------------------------------  1 [R] COG1634 Uncharacterized Rossmann fold enzyme
||||--|||||||||--|------------------------------------------------  1 [H] COG1635 Flavoprotein involved in thiazole biosynthesis
||||||||||||||||--------------------------------------------------  1 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
-|||--|||||||-----------------------------------------------------  1 [R] COG1645 Uncharacterized Zn-finger containing protein
|||||||||||||---------------------||||----------------------------  1 [R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold
||||||--|||-|||-|---|------||-|---||||----||||||||--|||----|||||--  1 [H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)
-||||||||||||-----------------------------------------------------  1 [S] COG1650 Uncharacterized protein conserved in archaea
--||---||------------|--------||||||||----|||||-|||||-------------  1 [K] COG1654 Biotin operon repressor
--|------|---||---||----------------|-----------------------------  1 [I] COG1657 Squalene cyclase
|||-|||||-------|---|----|----|||||||||-||------------------------  1 [L] COG1658 Small primase-like proteins (Toprim domain)
|-||||||||--|---------------------|--------||-|-|----------||-|---  1 [R] COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif
|||-----||-|------------------------------------------------------  1 [S] COG1665 Uncharacterized protein conserved in archaea
||||--|||-|||----|---|--------||-|||||--------------|----------|--  1 [CP] COG1668 ABC-type Na+ efflux pump, permease component
||||--||||||||||--------------------------------------------------  1 [K] COG1675 Transcription initiation factor IIE, alpha subunit
||||||||||||||||--------------------------------------------------  1 [J] COG1676 tRNA splicing endonuclease
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1679 Uncharacterized conserved protein
--|-----|-------|-||------|||||||-||||--------|-||-||||---|-||||||  1 [GM] COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component
|-|-------------||--|---------|----|||--------|-||-----|---||-|---  1 [S] COG1683 Uncharacterized conserved protein
||||||-||||||-----------------------------------------------------  1 [EH] COG1685 Archaeal shikimate kinase
--|-----------------|-----|---------|-------------||----||--------  1 [E] COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance)
|||---|||-|||---||------------------------------------------------  1 [L] COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||||||||||||--|||-|-|----|||-|------|----|||-|--|-----|----------  1 [S] COG1690 Uncharacterized conserved protein
|||-----||-------|||------|---|-----------------------------------  1 [R] COG1691 NCAIR mutase (PurE)-related proteins
--|---|||||||---|||||||||||||-||--||||----|||||-|||||------|||||-|  1 [R] COG1694 Predicted pyrophosphatase
|-|||||||-|||----|-|||----||||||||||||----|||||-|------|------||--  1 [K] COG1695 Predicted transcriptional regulators
||||--||||||||||--------------------------------------------------  1 [L] COG1697 DNA topoisomerase VI, subunit A
|||-||||||-||-----------------------------------------------------  1 [S] COG1698 Uncharacterized protein conserved in archaea
||||--|||||||-----------------------------------------------------  1 [S] COG1701 Uncharacterized protein conserved in archaea
-||--------------|--|---|-------||-|--||---|||---|-|---|---|||||--  1 [S] COG1704 Uncharacterized conserved protein
-||||||||||||-----------------------------------------------------  1 [K] COG1709 Predicted transcriptional regulator
|-|||||||---------------------------------------------------------  1 [S] COG1711 Uncharacterized protein conserved in archaea
|||-----|||------|-------------------------------|-----|----------  1 [R] COG1712 Predicted dinucleotide-utilizing enzyme
|-||---------------|-|-----||-------------|---|-------------------  1 [V] COG1715 Restriction endonuclease
||||||||||||||||--------------------------------------------------  1 [J] COG1717 Ribosomal protein L32E
||||||||||||||||-----|-----------------------|---|----------------  1 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control
||||--|||||||----|------------------------|||||-||||-||-------||--  1 [S] COG1720 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1727 Ribosomal protein L18E
|||||||||||||||-|-------------------------------------------------  1 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding
|||-----|||||-----------------------------------------------------  1 [H] COG1731 Archaeal riboflavin synthase
||||||||||||||||--------------------------------------------------  1 [J] COG1736 Diphthamide synthase subunit DPH2
--||----|-|-|----|--||||-||-------|-|-----|||||-||||-||----||||---  1 [S] COG1738 Uncharacterized conserved protein
--||---------||--|--||---||---||||||||||--|||-|-||||-|||||||||----  1 [S] COG1739 Uncharacterized conserved protein
--|-||----|-------||------|||-|-----------|||||-||-|---|---|||||--  1 [R] COG1741 Pirin-related protein
--|---------------|--------||-----|-||----|||-|--|-----|---||-||--  1 [S] COG1742 Uncharacterized conserved protein
||||----||--------------------------------------------------------  1 [R] COG1745 Predicted metal-binding protein
|||||||||||||-----------------------------------------------------  1 [J] COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme)
-||---|||-|||-----------------------------------------------------  1 [R] COG1750 Archaeal serine proteases
|||-----|--------|------------------------------------------------  1 [S] COG1751 Uncharacterized conserved protein
-||---|||---------------------------------------------------------  1 [S] COG1753 Uncharacterized conserved protein
||||||||||||||||||||-|--||||||||||||||----|||||-||||||||||||||||||  1 [K] COG1758 DNA-directed RNA polymerase, subunit K/omega
||||||||||||||||--------------------------------------------------  1 [K] COG1761 DNA-directed RNA polymerase, subunit L
|||||-|||||||---|-----------------||||----|||||-|-||---|--|||||---  1 [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein
-||-||||-|-||---||---|----|||-|----|-|--|||||||-||---|||---||-||--  1 [O] COG1765 Predicted redox protein, regulator of disulfide bond formation
|||---||||-||-------|-----------|---------|||-|-|||---------------  1 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase
-||---||||--------------------------------------------------------  1 [S] COG1772 Uncharacterized protein conserved in archaea
|-|||||||---------------------------------------------------------  1 [K] COG1777 Predicted transcriptional regulators
--|-------------|---|---------------------|||||-|||||||||||-------  1 [R] COG1778 Low specificity phosphatase (HAD superfamily)
|||-|||||||||||---------------------------------------------------  1 [R] COG1779 C4-type Zn-finger protein
|||||||||||||----|------------|-----------|||||||----||-----------  1 [F] COG1781 Aspartate carbamoyltransferase, regulatory subunit
|||||||||||||-----------------------------------------------------  1 [R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain
||||--||||--------------------------------------------------------  1 [S] COG1784 Predicted membrane protein
--||---|-----||--|-|-|----|-------|-||----||||---|--|--|-----|----  1 [P] COG1785 Alkaline phosphatase
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1786 Uncharacterized conserved protein
|-|-||-------||-|----|------------||||----------------------------  1 [L] COG1796 DNA polymerase IV (family X)
||||||||||||||||--------------------------------------------------  1 [J] COG1798 Diphthamide biosynthesis methyltransferase
--|-|||||-|||---||-|-|------------||||----|||||-||-|---|---||-||--  1 [S] COG1801 Uncharacterized conserved protein
-|||----|---|-----||-------------|--------------------------------  1 [S] COG1808 Predicted membrane protein
||||||||||||||||--------------------------------------------------  1 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1
|||-----||--------------------------------------------------------  1 [R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)
||||||||||||----||||-|----||||-|--||||--------------------|-||||--  1 [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component
||||--|||||||-----------------------------------------------------  1 [R] COG1829 Predicted archaeal kinase (sugar kinase superfamily)
|||||||||||-|-----------------------------------------------------  1 [R] COG1831 Predicted metal-dependent hydrolase (urease superfamily)
||||-|||||||-----|------------------------------------------------  1 [S] COG1833 Uncharacterized conserved protein
|||||||||-|-------||-----------------|----------------------------  1 [S] COG1836 Predicted membrane protein
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain
||||||||||||||||||--||--||||||||||||||----||||||||||||||----||||||  1 [J] COG1841 Ribosomal protein L30/L7E
--|-------------|-||-|----|||-|----|||----|||||-||------------||--  1 [KT] COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription
|||---||-|--------------------------------------------------------  1 [S] COG1844 Uncharacterized protein conserved in archaea
|||||||||||||-----------------------------------------------------  1 [S] COG1849 Uncharacterized protein conserved in archaea
-||---|||---------||----------------|-----------------------|-|---  1 [G] COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit
|||||||||||||-----------------------------------------------------  1 [R] COG1855 ATPase (PilT family)
|||---|||-|||---|---|---------------------------------------------  1 [L] COG1857 Uncharacterized protein predicted to be involved in DNA repair
--|-|||||||-|||-----||--------------------|||----|---------|------  1 [J] COG1859 RNA:NAD 2'-phosphotransferase
|||||||-|-|-------------------------------------------------------  1 [S] COG1860 Uncharacterized protein conserved in archaea
||||--||---------|---|----|-------||||----------||---------|||--||  1 [P] COG1863 Multisubunit Na+/H+ antiporter, MnhE subunit
--|----------||----||----|--------------------|--|-----||||----|--  1 [F] COG1864 DNA/RNA endonuclease G, NUC1
-||||||||||||-----------------------||----------------------------  1 [S] COG1865 Uncharacterized conserved protein
|||||||||||||||||-------------------------------------------------  1 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase
|||----|||--|------|--||----|-------------|||||-|--|-------|--||||  1 [S] COG1872 Uncharacterized conserved protein
--|--------------|--|---|-|--|||----||----|||||-||||---|---|||||--  1 [G] COG1879 ABC-type sugar transport system, periplasmic component
|-|||||||--|-|--|-----||--|||||---|-|-|---|||-|-|--|||||||-||-|--|  1 [R] COG1881 Phospholipid-binding protein
-|||--||||--------------------------------------------------------  1 [S] COG1885 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1889 Fibrillarin-like rRNA methylase
||||||||||||||||--------------------------------------------------  1 [J] COG1890 Ribosomal protein S3AE
|||-----||--------------------------------------------------------  1 [S] COG1891 Uncharacterized protein conserved in archaea
|-||--||||||------------------------------------------------------  1 [S] COG1892 Uncharacterized protein conserved in archaea
-||---|-|--------|------------------------------------------------  1 [S] COG1895 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
-|||--|||||-|-----------------------------------|-----------------  1 [S] COG1901 Uncharacterized conserved protein
|||-||--||||------|||---------|----|----------|--|-----|---|-|----  1 [H] COG1903 Cobalamin biosynthesis protein CbiD
|||-----||--------------------------------------------------------  1 [C] COG1908 Coenzyme F420-reducing hydrogenase, delta subunit
|||-|||||||||-----------------------------------------------------  1 [S] COG1909 Uncharacterized protein conserved in archaea
-|||||--|-|-------------------|-----|------------------|----------  1 [P] COG1910 Periplasmic molybdate-binding protein/domain
|||---||||||||||--------------------------------------------------  1 [J] COG1911 Ribosomal protein L30E
-|||--|||||||---||-|-------------|||-------||-----------||--------  1 [S] COG1912 Uncharacterized conserved protein
||||--||||--------------||--------------------------|-------------  1 [S] COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein)
||||----||-----------------|||------------------------------------  1 [S] COG1920 Uncharacterized conserved protein
|||-----||------||--|---------||---|------|||---------------------  1 [I] COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)
--|-||----------|--|-------||--------------------------|||--|-|---  1 [R] COG1926 Predicted phosphoribosyltransferases
|||-----||--------------------------------------------------------  1 [C] COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase
||||----|----------|---------------|----------|-------------------  1 [P] COG1930 ABC-type cobalt transport system, periplasmic component
||||--|||||||-----------------------------------------------------  1 [S] COG1931 Uncharacterized protein conserved in archaea
--|----------||----|------||||-|---|||----||||||||||||||--||||||--  1 [HE] COG1932 Phosphoserine aminotransferase
||||||||||--------------------------------------------------------  1 [L] COG1933 Archaeal DNA polymerase II, large subunit
-||---||||--------------------------------------------------------  1 [S] COG1935 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)
|||||||||||||-----------------------------------------------------  1 [R] COG1938 Archaeal enzymes of ATP-grasp superfamily
|||---||||--------||----------------------------------------------  1 [C] COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit
||||-----|-----------------||-------------|||||--|||-------||-|---  1 [S] COG1944 Uncharacterized conserved protein
||||--||||||||||--------------------------------------------------  1 [L] COG1948 ERCC4-type nuclease
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain
--|----|--|-|---|---|-----|||-||----||----|||||-||||-||||||-------  1 [T] COG1966 Carbon starvation protein, predicted membrane protein
||||--|||---------------------------------------------------------  1 [S] COG1967 Predicted membrane protein
--|---------------|-||----||||-||||||-----|||||-|||||--|---|||||--  1 [M] COG1970 Large-conductance mechanosensitive channel
|-|-----------------|-----|---|-----||----|||||--|--|||---|-------  1 [S] COG1971 Predicted membrane protein
|||-----||-|------------------------------------------------------  1 [O] COG1973 Hydrogenase maturation factor
||||||||||||||||--------------------------------------------------  1 [J] COG1976 Translation initiation factor 6 (eIF-6)
||||||||||||||||----------|---------------------------------------  1 [S] COG1990 Uncharacterized conserved protein
||||--||-||||----|------------------------------------------------  1 [S] COG1992 Uncharacterized conserved protein
|||||||||||||||---------------|-----------------------------------  1 [K] COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger)
|||||||||||||||---------------------------------------------------  1 [J] COG1998 Ribosomal protein S27AE
--|-------------|||||---------||||||||----|||||-||||||||---||||--|  1 [L] COG2003 DNA repair proteins
||||||||||||||||--------------------------------------------------  1 [J] COG2004 Ribosomal protein S24E
|-|-----||||------------------------------|||||--|||---|--|||-||--  1 [R] COG2005 N-terminal domain of molybdenum-binding protein
||||||||||||||||--------------------------------------------------  1 [J] COG2007 Ribosomal protein S8E
--|-----|---------||-|----||||------||----------||---|||||||||||--  1 [C] COG2010 Cytochrome c, mono- and diheme variants
||||||||||||||||--------------------------------------------------  1 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5
|||---||----------------------------------------------------------  1 [S] COG2014 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2016 Predicted RNA-binding protein (contains PUA domain)
|-||---------||------|----||||----||-------------|||||||------||--  1 [E] COG2021 Homoserine acetyltransferase
||||||||||-|||||--------------------------------------------------  1 [J] COG2023 RNase P subunit RPR2
|||-----||--------------------------------------------------------  1 [J] COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type)
--|---------------||-|----||||------|-----|||||-||||||||----------  1 [M] COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)
|||---||-|--------------------------------------------------------  1 [S] COG2029 Uncharacterized conserved protein
--|----------||-|----|-----||||-----|-----|||||-|--|-|||----||-|--  1 [P] COG2032 Cu/Zn superoxide dismutase
|||---|||--------|------|-----|-----------------------------------  1 [C] COG2033 Desulfoferrodoxin
|||-||||||-||-----------------------------------------------------  1 [S] COG2034 Predicted membrane protein
||||--||||---|||--------------------------------------------------  1 [B] COG2036 Histones H3 and H4
|||-----||--------------------------------------------------------  1 [C] COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase
|||||||||||||-----||||----|||||------|----|||-|-||-----|---|||||--  1 [H] COG2038 NaMN:DMB phosphoribosyltransferase
--||||--|-|||---|--|-|----|||-------|-----|||||--|-|---|--||||||--  1 [R] COG2041 Sulfite oxidase and related enzymes
||||||---|-|-|||--------------------------------------------------  1 [S] COG2042 Uncharacterized conserved protein
||||||||||--------------------------------------------------------  1 [R] COG2047 Uncharacterized protein (ATP-grasp superfamily)
--|||||||-||--|-|----|----|||--|||||||----|||||-||||---|||||||||--  1 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism
||||||||||||||||--------------------------------------------------  1 [J] COG2051 Ribosomal protein S27E
||||||||||||||||--------------------------------------------------  1 [J] COG2053 Ribosomal protein S28E/S33
|||-----||--------------------------------------------------------  1 [R] COG2054 Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases
||||||||||||||||--------------------------------------------------  1 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2
|||-----||--------------------------------------------------------  1 [E] COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase
||||||||||||||||--------------------------------------------------  1 [J] COG2075 Ribosomal protein L24E
--||---------------|-|-----|||||---|||----|||||-||---||---||||||--  1 [P] COG2076 Membrane transporters of cations and cationic drugs
|||||||||||||||-||------------|-----------------------------------  1 [S] COG2078 Uncharacterized conserved protein
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2082 Precorrin isomerase
|-|-||----|||---|-||-|-----||-||---|||----|||||-||||-|||-|-|||||--  1 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
||||----||---------|------|----|--------------------|--|---||-|---  1 [R] COG2085 Predicted dinucleotide-binding enzymes
-||-----------------|---|-----|-----|----------------|--|||----|--  1 [M] COG2089 Sialic acid synthase
|||||||||||||||---------------------------------------------------  1 [J] COG2092 Translation elongation factor EF-1beta
|||||||||||||-----------------------------------------------------  1 [K] COG2093 DNA-directed RNA polymerase, subunit E''
-||-|||||||||---|--|-||||-----------|-----||||||||-|||||--||||||--  1 [U] COG2095 Multiple antibiotic transporter
||||||||||||||||--------------------------------------------------  1 [J] COG2097 Ribosomal protein L31E
||||||--||--------------------------------------------------------  1 [S] COG2098 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [R] COG2102 Predicted ATPases of PP-loop superfamily
-||---|---||------||-|--------------||----|||||-||-----|----------  1 [S] COG2105 Uncharacterized conserved protein
-|||--|||||||-----------------|-----------------------------------  1 [R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme
--||||||--|------|||||-----||-------------|||||-||-----|---||||---  1 [H] COG2109 ATP:corrinoid adenosyltransferase
--|-||||||||||--||--||-----||---|-||------|||-|--|-----|------|---  1 [R] COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1
--|----------------------|-----||--||-----|||||--|-----|---||||---  1 [E] COG2113 ABC-type proline/glycine betaine transport systems, periplasmic components
--|----------|||--||----|-||||-------------------|---------||-||--  1 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)
||||--||----------------------------------------------------------  1 [J] COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain
|||||||||||||||---------------------------------------------------  1 [R] COG2118 DNA-binding protein
--|---||-|-|-|||-----|----||||----|-||----|--|-------------||||---  1 [S] COG2120 Uncharacterized proteins, LmbE homologs
|||-----||----------------------------------------------------|---  1 [S] COG2122 Uncharacterized conserved protein
|-|-||||||||||||--------------------------------------------------  1 [J] COG2123 RNase PH-related exoribonuclease
||||||||||||||||--------------------------------------------------  1 [J] COG2125 Ribosomal protein S6E (S10)
||||||||||-|||||--------------------------------------------------  1 [J] COG2126 Ribosomal protein L37E
--|-----|----------|-|----|||||--||-||----|||||--|---|||---|||||--  1 [S] COG2128 Uncharacterized conserved protein
|||---|||||||---|-------------------------------------------|-----  1 [R] COG2129 Predicted phosphoesterases, related to the Icc protein
|||---||||||||||--------------------------------------------------  1 [JA] COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain
||||----||||------||-|----|||-----|-||-----------------|----------  1 [S] COG2138 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2139 Ribosomal protein L21E
--|---|||---------|-----------------|---------|--------|---||-|---  1 [GR] COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes
||||----||-|-------|-|----||||--||||||-|--|||||--|--|--|---|||||--  1 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
|||------|--------|-----------------------------------------------  1 [R] COG2144 Selenophosphate synthetase-related proteins
--|---|||----||-----------|---||-|||||----|||-|---||----||-|------  1 [H] COG2145 Hydroxyethylthiazole kinase, sugar kinase family
--||||----||--|---||-|----||------|-||----|||||--|--|--|---||-||--  1 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases
||||||||||||||||--------------------------------------------------  1 [J] COG2147 Ribosomal protein L19E
|-|||||||---------------------------------------------------------  1 [R] COG2150 Predicted regulator of amino acid metabolism, contains ACT domain
|||---||||||||||--------------------------------------------------  1 [J] COG2157 Ribosomal protein L20A (L18A)
|||-----||--------------------|-----------------------------------  1 [R] COG2158 Uncharacterized protein containing a Zn-finger-like domain
||||||||||-|||||--------------------------------------------------  1 [J] COG2167 Ribosomal protein L39E
-||---|||||||-|---------------------------------------------------  1 [J] COG2178 Predicted RNA-binding protein of the translin family
--|-----------------||---|----||||||||----|||||-|-||------|-|--|--  1 [E] COG2195 Di- and tripeptidases
--||||--|-||----|---|-------------|-|-----------------------------  1 [S] COG2210 Uncharacterized conserved protein
|-||--||---------|---|----|-------||||----------||---------|||--|-  1 [P] COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit
||||||||||||||||--------------------------------------------------  1 [L] COG2219 Eukaryotic-type DNA primase, large subunit
|||-----|||-------------------|---------------|-------------------  1 [C] COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits
|||-||-----|----||----------------||--------------------|||-------  1 [L] COG2231 Uncharacterized protein related to Endonuclease III
|||-----||--------------------------------------------------------  1 [R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase
|-||--||||---||-|--|-------||-|-----||----|||-|-||--|----------|--  1 [R] COG2234 Predicted aminopeptidases
-||||||||-|||-----------------------------------------------------  1 [S] COG2237 Predicted membrane protein
||||||||||||||||--------------------------------------------------  1 [J] COG2238 Ribosomal protein S19E (S16A)
||||||--||||------|||-----|||-|----|----------|--|-----|---||||---  1 [H] COG2241 Precorrin-6B methylase 1
||||||--||||------|||-----|||-|----|----------|--|---------||||---  1 [H] COG2242 Precorrin-6B methylase 2
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2243 Precorrin-2 methylase
|||||||||||||||---------------------------------------------------  1 [J] COG2260 Predicted Zn-ribbon RNA-binding protein
-|||--||-||||---||||||||--||||||||||||----|||||-||-|||||---|||||--  1 [R] COG2262 GTPases
|||||||||||||--|--------------------------------------------------  1 [J] COG2263 Predicted RNA methylase
|||||||||||||-----------------------------------------------------  1 [H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase
-||---------------||-|---|-||--|--|-||-----------|-----|----------  1 [S] COG2314 Predicted membrane protein
--||-----------------|-----|||------||----------||----------------  1 [S] COG2320 Uncharacterized conserved protein
--|------------------|--------------------|||||-|||||------|||||||  1 [O] COG2332 Cytochrome c-type biogenesis protein CcmE
--|---------------|-||--------------||----|||||-||---|||---|||||--  1 [R] COG2334 Putative homoserine kinase type II (protein kinase fold)
--|------------------|--||------|||-------------------------------  1 [V] COG2348 Uncharacterized protein involved in methicillin resistance
--|-----|------------|--------------------|||||-|||||------|||||--  1 [O] COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component
--|-------------|-||-|--------------------------------------------  1 [R] COG2389 Uncharacterized metal-binding protein
--||-------||-------|---------------|-------------------|||-------  1 [R] COG2404 Predicted phosphohydrolase (DHH superfamily)
|-|-------|||----|------------------------------------------------  1 [R] COG2406 Protein distantly related to bacterial ferritins
--||||||||-||-----------------------------------------------------  1 [S] COG2412 Uncharacterized conserved protein
|-||||--|||||||-----------|-------|----------|---|-----|---||||---  1 [E] COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog
--|---|||-|-|-----------------------------------------------------  1 [S] COG2430 Uncharacterized conserved protein
|-||--|||||||-----------------------------------------------------  1 [S] COG2433 Uncharacterized conserved protein
||||||||||--||||--------------------------------------------------  1 [U] COG2443 Preprotein translocase subunit Sss1
||||||||||--------------------------------------------------------  1 [S] COG2450 Uncharacterized conserved protein
|||---||-|-|------------------|-----------------------------------  1 [S] COG2454 Uncharacterized conserved protein
|||---||||-|------------------------------------------------------  1 [S] COG2457 Uncharacterized conserved protein
-|||--|||---------------------------------------------------------  1 [S] COG2469 Uncharacterized conserved protein
--|---||||||-----||-|---------||-----|----------|--------------|--  1 [R] COG2509 Uncharacterized FAD-dependent dehydrogenases
|||||||||||||-----------------------------------------------------  1 [J] COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain)
--|---||---|----|||-----------------------------------------------  1 [R] COG2516 Biotin synthase-related enzyme
||||----|-|||-----------------------------------------------------  1 [K] COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains
--|-----------------|-----|---|-|-|-||----|||||-||||-|||----------  1 [GE] COG2610 H+/gluconate symporter and related permeases
|||||||||------------|--------------------------------------------  1 [C] COG2811 Archaeal/vacuolar-type H+-ATPase subunit H
--|----------||------|----|||-|-----------|||||-||||-------|||||--  1 [L] COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding
--||------|||-------------||||------------|||||-||-|||||----||||--  1 [S] COG2835 Uncharacterized conserved protein
--|------------------|-----||---||-||----------------||-----|-||--  1 [M] COG2843 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)
-||------||||-------------|---||-|-|-----------------||-----------  1 [S] COG2848 Uncharacterized conserved protein
--|-------------|----|--------------------|||-||||||---|||||---|--  1 [S] COG2862 Predicted membrane protein
--|----------||---|-----------------||----|||||--|---|||-------|--  1 [E] COG2866 Predicted carboxypeptidase
--|-||||--||||---|--||--------|------|----------||-----|---||||---  1 [R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain
--||---------||--|---|----|||-||---|-|-----------|-|---|--|||||---  1 [E] COG2873 O-acetylhomoserine sulfhydrylase
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2875 Precorrin-4 methylase
--|--------------|--|---------------------||||||||||||||----------  1 [C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB
--|---------|-----------|-||||-------------------------|||||||||||  1 [L] COG2887 RecB family exonuclease
|||||||||||||-----------------------------------------------------  1 [J] COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG2890 Methylase of polypeptide chain release factors
|||---||||--|-----------------------------------------------------  1 [S] COG2892 Uncharacterized protein conserved in archaea
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [H] COG2896 Molybdenum cofactor biosynthesis enzyme
--|-----------------------||||-|--|||------------|--|--|---|||||--  1 [S] COG2898 Uncharacterized conserved protein
|-|--------------|------------------------||||||||||--------------  1 [P] COG2923 Uncharacterized protein involved in the oxidation of intracellular sulfur
--|----------|||------||----------------------------|--|------|---  1 [R] COG2940 Proteins containing SET domain
--||--------------||-------||--------|----|||||-|---|------|||||--  1 [S] COG2968 Uncharacterized conserved protein
--||----------------------||-------|||----|||||-||-|-||----||||---  1 [R] COG3030 Protein affecting phage T7 exclusion by the F plasmid
--|---------------|------------|--|-|---------|-|----------|-||---  1 [M] COG3049 Penicillin V acylase and related amidases
--|-----------------------|----||---------|||||-||--|--|---|||||--  1 [P] COG3158 K+ transporter
|||-----||-----------------|||------------|||||-||-|-|||----------  1 [H] COG3161 4-hydroxybenzoate synthetase (chorismate lyase)
--||-----------------|-----||--|---|||-----------|-----|---||-||-|  1 [R] COG3173 Predicted aminoglycoside phosphotransferase
|-||-----|--|---|--------------------------------|-----|----|-|---  1 [S] COG3174 Predicted membrane protein
--|------------------|------------------------|-||------------|---  1 [V] COG3183 Predicted restriction endonuclease
--|---------------|-||----|---------------|||||-||-----||||||||---  1 [O] COG3187 Heat shock protein
--|-----------------|-----------|-||||----------||---||-------||--  1 [S] COG3212 Predicted membrane protein
||||----||--------------------------------------------------------  1 [H] COG3252 Methenyltetrahydromethanopterin cyclohydrolase
|||---||||--------||----------------------------------------------  1 [C] COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit
|||--|||-|-|---------------||-------------|||-|-------------------  1 [C] COG3260 Ni,Fe-hydrogenase III small subunit
|||--|||-|-|---------------|--------------|||-|-------------------  1 [C] COG3261 Ni,Fe-hydrogenase III large subunit
--|---||-------------------|--------------|||-|-------------------  1 [C] COG3262 Ni,Fe-hydrogenase III component G
|-|----------------------------------------------|---|||--|-------  1 [R] COG3271 Predicted double-glycine peptidase
|-|---------------------------------------|||||-||----------------  1 [S] COG3272 Uncharacterized conserved protein
|-||--||||--|-----------------------------------------------------  1 [S] COG3273 Uncharacterized conserved protein
-||-||---|-|----|-------------------------|||-|--|||------|-|-----  1 [J] COG3276 Selenocysteine-specific translation elongation factor
|||||||||||-||||--------------------------------------------------  1 [J] COG3277 RNA-binding protein involved in rRNA processing
--|----------------------------|||-|||--------|--|---||-|--|------  1 [S] COG3326 Predicted membrane protein
--|-||-----|------|--------||-||-----||----||||--------|----|-|---  1 [L] COG3328 Transposase and inactivated derivatives
|-|---------------||----------|-----||-----------------|---|||||--  1 [S] COG3339 Uncharacterized conserved protein
|-||--------------------------|-----||----------------------------  1 [L] COG3359 Predicted exonuclease
|-||----||--------------------------------------------------------  1 [R] COG3364 Zn-ribbon containing protein
|-||----||--------------------------------------------------------  1 [S] COG3365 Uncharacterized protein conserved in archaea
--|||||||-||-------|----------------------------------------------  1 [S] COG3372 Uncharacterized conserved protein
--|-||--|---------------------------||----------------------------  1 [S] COG3377 Uncharacterized conserved protein
--|-|------|--|---------------|-----------|||||--|-|---|-------|--  1 [S] COG3384 Uncharacterized conserved protein
--||||--||--------------------------------------------------------  1 [S] COG3388 Uncharacterized protein conserved in archaea
--||||--|---------------------------------------------------------  1 [S] COG3389 Uncharacterized protein conserved in archaea
--|----------------|----|--||------|-|-------------------------|--  1 [R] COG3393 Predicted acetyltransferase
--|---------------||-|----|||||-----||----------|------|---||||---  1 [M] COG3409 Putative peptidoglycan-binding domain-containing protein
--|---------------------------------------||||---|-|-||----|-|||--  1 [S] COG3422 Uncharacterized conserved protein
||||||||||||||||---------|-----||||||--------|-----------------|--  1 [I] COG3425 3-hydroxy-3-methylglutaryl CoA synthase
--||||||-|||----|-||----------------------------------------------  1 [S] COG3431 Predicted membrane protein
-||-||--|-|||-----------------------------------------------------  1 [K] COG3432 Predicted transcriptional regulator
--||||-----|----|-------|---------------------|------||------|----  1 [S] COG3439 Uncharacterized conserved protein
--|-----|-----|---||----------||----|----------------------||-----  1 [T] COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
-||-----------------|----------|----|-----------------------------  1 [R] COG3478 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain
|-|------------------------||------------------------------||-|---  1 [S] COG3482 Uncharacterized conserved protein
|-|-----|----------------------------------------|-----|---|||||--  1 [S] COG3503 Predicted membrane protein
|-|-----|---------------------|----------------------------|-||---  1 [S] COG3543 Uncharacterized conserved protein
--|----------------------------------------||-----|-----||---|----  1 [S] COG3586 Uncharacterized conserved protein
--|-----------------------||||-|||------------------|----------|--  1 [O] COG3590 Predicted metalloendopeptidase
--|----------------------------|---|------|||-----------------|---  1 [S] COG3592 Uncharacterized conserved protein
--|---------------------------|---|||------------|--|---------|---  1 [G] COG3594 Fucose 4-O-acetylase and related acetyltransferases
--|-----|------------|-------------------------------------||-|---  1 [S] COG3603 Uncharacterized conserved protein
-||||||||-|||------|-------||--------------||||-----|--|---||-||--  1 [K] COG3609 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain
--||||--|---------------------------------------------------------  1 [S] COG3612 Uncharacterized protein conserved in archaea
--|-----------|----------|-----|------|----------|-----|---|--||--  1 [F] COG3613 Nucleoside 2-deoxyribosyltransferase
--|---------------|-|------||-||||-||------------|-----|---||||---  1 [S] COG3619 Predicted membrane protein
--|||||||---------------------------------------------------------  1 [K] COG3620 Predicted transcriptional regulator with C-terminal CBS domains
--||-----------------|-----||-------|------------|---------|--||--  1 [R] COG3631 Ketosteroid isomerase-related protein
|||-|||||||||---||---|--------------------------------------------  1 [G] COG3635 Predicted phosphoglycerate mutase, AP superfamily
||||||||||||||||--------------------------------------------------  1 [T] COG3642 Mn2+-dependent serine/threonine protein kinase
--|-----------|------|--------------------|||-|----|-|||--|----|--  1 [L] COG3663 G:T/U mismatch-specific DNA glycosylase
-||-----|||---------------||||||-|-|-------------|---||-----------  1 [T] COG3830 ACT domain-containing protein
--|--------------|--------|||-|---||||-----------|-----|---||-||--  1 [S] COG3832 Uncharacterized conserved protein
--|------------------|--------|||-||||----------------------------  1 [P] COG3853 Uncharacterized protein involved in tellurite resistance
|-|---------------------------|-----||----------------------------  1 [S] COG3874 Uncharacterized conserved protein
--|-----------------|-----|---|---|-------------|-------||--------  1 [L] COG3886 Predicted HKD family nuclease
--|-----------------------|----------|---------------------|--|---  1 [R] COG3910 Predicted ATPase
--|---------------||----------|------|----------------------------  1 [S] COG3937 Uncharacterized conserved protein
--|----------||------------|||||--|-----------|-------------------  1 [GHR] COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes
|||------|--------------------------------------------------------  1 [R] COG4002 Predicted phosphotransacetylase
--|-||--||--------------------------------------------------------  1 [S] COG4004 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [K] COG4008 Predicted metal-binding transcription factor
|-|-----||--------------------------------------------------------  1 [S] COG4012 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4014 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4020 Uncharacterized protein conserved in archaea
|-|------|---||---------------------------------------------------  1 [S] COG4021 Uncharacterized conserved protein
|||------|--------------------------------------------------------  1 [S] COG4029 Uncharacterized protein conserved in archaea
--||----||--------------------------------------------------------  1 [R] COG4031 Predicted metal-binding protein
|||------|--------------------------------------------------------  1 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein
--||--||-|--------------------------------------------------------  1 [S] COG4044 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4050 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4051 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [R] COG4052 Uncharacterized protein related to methyl coenzyme M reductase subunit C
|||------|--------------------------------------------------------  1 [H] COG4054 Methyl coenzyme M reductase, beta subunit
|||------|--------------------------------------------------------  1 [H] COG4055 Methyl coenzyme M reductase, subunit D
|||------|--------------------------------------------------------  1 [H] COG4056 Methyl coenzyme M reductase, subunit C
|||------|--------------------------------------------------------  1 [H] COG4057 Methyl coenzyme M reductase, gamma subunit
|||------|--------------------------------------------------------  1 [H] COG4058 Methyl coenzyme M reductase, alpha subunit
|||------|--------------------------------------------------------  1 [H] COG4059 Tetrahydromethanopterin S-methyltransferase, subunit E
|||------|--------------------------------------------------------  1 [H] COG4060 Tetrahydromethanopterin S-methyltransferase, subunit D
|||------|--------------------------------------------------------  1 [H] COG4061 Tetrahydromethanopterin S-methyltransferase, subunit C
|||------|--------------------------------------------------------  1 [H] COG4062 Tetrahydromethanopterin S-methyltransferase, subunit B
|||------|--------------------------------------------------------  1 [H] COG4064 Tetrahydromethanopterin S-methyltransferase, subunit G
|||------|--------------------------------------------------------  1 [S] COG4065 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [O] COG4070 Predicted peptidyl-prolyl cis-trans isomerase (rotamase), cyclophilin family
|||------|--------------------------------------------------------  1 [S] COG4073 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4079 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4081 Uncharacterized protein conserved in archaea
--||----||--------------------------------------------------------  1 [S] COG4083 Predicted membrane protein
|||------|--------------------------------------------------------  1 [R] COG4087 Soluble P-type ATPase
--|-----||||------------------------------------------------------  1 [S] COG4089 Predicted membrane protein
|||------|--------------------------------------------------------  1 [S] COG4090 Uncharacterized protein conserved in archaea
--|----------------|-------------------------|--||-----|---|--|---  1 [S] COG4104 Uncharacterized conserved protein
--||--------|-|-|-||||----||||||||||||-----------|---||-------|---  1 [R] COG4122 Predicted O-methyltransferase
--|---------------------------|---------------|----------------|--  1 [S] COG4127 Uncharacterized conserved protein
-||----------------------------|-|||||-------------------------|--  1 [R] COG4152 ABC-type uncharacterized transport system, ATPase component
--|----------------------|-----||--||-----|||||--|-----|---||||---  1 [E] COG4175 ABC-type proline/glycine betaine transport system, ATPase component
--|----------------------|-----||--||-----|||||--|-----|---||||---  1 [E] COG4176 ABC-type proline/glycine betaine transport system, permease component
|||------|--------------------------------------------------------  1 [H] COG4218 Tetrahydromethanopterin S-methyltransferase, subunit F
--|------------------|-----------|--------|--|------------|-------  1 [V] COG4268 McrBC 5-methylcytosine restriction system component
--|------------------------------------|------------|--|-------|--  1 [K] COG4271 Predicted nucleotide-binding protein containing TIR -like domain
--|--------|------||------|||-------------------------------------  1 [S] COG4279 Uncharacterized conserved protein
--|----------------------------|----------|||||-|--|----------|---  1 [CH] COG4635 Flavodoxin
--|--------------|--|---||---------|------||||||||||--------------  1 [C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC
--|--------------|--|---------------------||||||||||--------------  1 [C] COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA
--|--------------|--|---|-----------------||||||||||--------------  1 [C] COG4658 Predicted NADH:ubiquinone oxidoreductase, subunit RnfD
--|--------------|--|---------------------||||||||||--------------  1 [C] COG4659 Predicted NADH:ubiquinone oxidoreductase, subunit RnfG
--|--------------|--|---------------------||||||||||--------------  1 [C] COG4660 Predicted NADH:ubiquinone oxidoreductase, subunit RnfE
--|----------------------------||-------------|--|----------------  1 [E] COG4690 Dipeptidase
--|-------------------------------|||-----------------------|-----  1 [S] COG4717 Uncharacterized conserved protein
|-|------|--------------------------------------------------------  1 [R] COG4740 Predicted metalloprotease
--|-||----|------|------------------------------------------------  1 [F] COG4741 Predicted secreted endonuclease distantly related to archaeal Holliday junction resolvase
|-|---||----------------------------------------------------------  1 [S] COG4743 Predicted membrane protein
--||----|---------------------------------------------------------  1 [O] COG4745 Predicted membrane-bound mannosyltransferase 
|-|-----|---------------------------------------------------------  1 [R] COG4747 ACT domain-containing protein
--|----------------|-----||--------|------------------------------  1 [S] COG4748 Uncharacterized conserved protein
--||----|---------------------------------------------------------  1 [S] COG4749 Uncharacterized protein conserved in archaea
-||-----|---------------------------------------------------------  1 [K] COG4800 Predicted transcriptional regulator with an HTH domain
--||----||--------------------------------------------------------  1 [R] COG4801 Predicted acyltransferase
--|--------|----|-------------------------------------------------  1 [S] COG4831 Uncharacterized conserved protein
--|-----------------|----------|---|------------------------------  1 [S] COG4832 Uncharacterized conserved protein
--|---------------|--|--------|-----------------------------------  1 [V] COG4845 Chloramphenicol O-acetyltransferase
--|----||---------------------------------------------------------  1 [S] COG4854 Predicted membrane protein
--|-||--|---------------------------------------------------------  1 [S] COG4860 Uncharacterized protein conserved in archaea
--|-----------------|-----------------|-----------------||--------  1 [S] COG4866 Uncharacterized conserved protein
--|----------------|-----------------------------------------||---  1 [S] COG4872 Predicted membrane protein
|-|-----|---------------------------------------------------------  1 [S] COG4883 Uncharacterized protein conserved in archaea
--||----|---------------------------------------------------------  1 [S] COG4885 Uncharacterized protein conserved in archaea
--|----------|||---|----------|-|--|------|||||--|-----|----------  1 [S] COG4886 Leucine-rich repeat (LRR) protein
-||------|--------------------------------------------------------  1 [R] COG4887 Uncharacterized metal-binding protein conserved in archaea
--|------------------|----|------------------------------------|--  1 [S] COG4891 Uncharacterized conserved protein
|-|---------------------------|-----------------------------------  1 [R] COG4892 Predicted heme/steroid binding protein
--|-----------------------|------|--|-----------------------------  1 [S] COG4894 Uncharacterized conserved protein
--|------------------|--------------|-----------------------------  1 [S] COG4895 Uncharacterized conserved protein
-||----|----------------------------------------------------------  1 [S] COG4902 Uncharacterized protein conserved in archaea
|-|----|----------------------------------------------------------  1 [S] COG4906 Predicted membrane protein
-||-----------------|---------------------------------------------  1 [S] COG4907 Predicted membrane protein
--|------------------------||-|----|------------------------------  1 [R] COG4908 Uncharacterized protein containing a NRPS condensation (elongation) domain
--|-----------------|-----|----|---|------------------------|-|--|  1 [L] COG4912 Predicted DNA alkylation repair enzyme
-||------|--------------------------------------------------------  1 [S] COG4921 Uncharacterized protein conserved in archaea
--|--------------|--------------------------------------------|---  1 [S] COG4923 Uncharacterized conserved protein
--|-------------------------------------------------|--|----------  1 [S] COG4925 Uncharacterized conserved protein
--|----------------||------------------------|-----|---------|----  1 [S] COG4929 Uncharacterized membrane-anchored protein
--|-------|-----------------------------------|-------------------  1 [O] COG4930 Predicted ATP-dependent Lon-type protease
--|----------||----|----------------------------|-----------------  1 [O] COG4935 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases
|||---------------------------------------------------------------  1 [J] COG4937 Predicted regulatory domain of prephenate dehydrogenase
--||-------------------------------|--------------------------|---  1 [S] COG4983 Uncharacterized conserved protein
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG4992 Ornithine/acetylornithine aminotransferase
--|-----------------|---------|----------------------------------|  1 [S] COG4997 Uncharacterized conserved protein
--|-----------------|---------|---------------------------|-------  1 [S] COG5015 Uncharacterized conserved protein
|||---|-|-------||--|---|-------|-------------|-||-|------|-------  1 [C] COG5016 Pyruvate/oxaloacetate carboxyltransferase
--|----------||----|----------------------------------------------  1 [S] COG5017 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG5256 Translation elongation factor EF-1alpha (GTPase)
||||||||||||||||--------------------------------------------------  1 [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)
--|-----------------|-----------------------------|--||------|----  1 [P] COG5266 ABC-type Co2+ transport system, periplasmic component
-||---||-||-------------------------------------------------------  1 [J] COG5270 PUA domain (predicted RNA-binding domain)
--|------------------|---------|--|||-----------------------------  1 [S] COG5280 Phage-related minor tail protein
--|-----------------|----------------|-----||||---||||||----|||---  1 [UW] COG5295 Autotransporter adhesin
-||---||-----------------------------------------|----------------  1 [S] COG5306 Uncharacterized conserved protein
--|--------------------------------------------------------||||---  1 [Q] COG5310 Homospermidine synthase
--|------------------|-----------------------------------------|--  1 [S] COG5316 Uncharacterized conserved protein
--|--------------------------------------------------------|-|-|--  1 [S] COG5323 Uncharacterized conserved protein
--|-----------------------|---------|-----------------------------  1 [M] COG5337 Spore coat assembly protein
--|--------------------------------|-------------------|----|-||--  1 [S] COG5361 Uncharacterized conserved protein
--|--------------------------------|--------------------------|--|  1 [R] COG5362 Phage-related terminase
-||---||----------------------------------------------------------  1 [S] COG5418 Predicted secreted protein
--||----|---------------------------------------------------------  1 [S] COG5427 Uncharacterized membrane protein
--|-||-----|-----------------------------------------------||-|---  1 [S] COG5466 Predicted small metal-binding protein
--|----------------------------------------------------|---||||---  1 [S] COG5470 Uncharacterized conserved protein
--|------------------|----||||------------------------------------  1 [M] COG5479 Uncharacterized protein potentially involved in peptidoglycan biosynthesis
--|-------|-|-----------------------------------------------------  1 [S] COG5483 Uncharacterized conserved protein
--|--------||----|--||----|-----|---------------------------------  1 [R] COG5496 Predicted thioesterase
--|------------------------------------------|-----------------|--  1 [R] COG5529 Pyocin large subunit
--|---------------||-------------|--------------------------------  1 [O] COG5549 Predicted Zn-dependent protease
-||-----|---------------------------------------------------------  1 [S] COG5561 Predicted metal-binding protein
--|----------------|---|-----------------------------------|------  1 [S] COG5563 Predicted integral membrane proteins containing uncharacterized repeats
--|---------------------------|-|----|----------------------------  1 [T] COG5585 NAD+--asparagine ADP-ribosyltransferase
|-|------|--------------------------------------------------------  1 [R] COG5643 Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E
--||-------------|---|--------|----|-|-----------------|----------  1 [S] COG5652 Predicted integral membrane protein
--|-----|-----------------|--------||--------------------------|--  1 [S] COG5658 Predicted integral membrane protein