(order) Archaeoglobales - 1 genome Functional categories Fun All J A K L B D Y V T M N Z W U O C G E F H I P Q R S COGs 1,245 152 2 64 67 3 9 -  8 26 27 13 -  -  16 48 120 35 109 44 83 33 59 10 199 197 proteins 2,036 161 2 111 100 7 19 -  22 107 54 19 -  -  25 71 239 64 174 50 108 113 102 39 383 259 Distribution of COGs by number of proteins proteins 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 24 25 COGs 932 182 44 38 10 8 4 5 4 1 5 2 2 3 1 1 1 1 1

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
|-||----|-----|-||||-|||-||||||----|||----|||||-||--|--|--||||||-- 25 [T] COG2202 FOG: PAS/PAC domain
|-||----|----||-||||||||-|||||||||||||----|||||-|||||||||||||||||| 24 [T] COG0642 Signal transduction histidine kinase
-|----|||-|||--------|-----||-------------------------------|----- 17 [R] COG1848 Predicted nucleic acid-binding protein, contains PIN domain
|-||||--|-|||||---||-|||--||||-||-||||----|||||-||||||||--|||||||| 16 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II
||||||||||||||||--|-||---||||||||-||||----|||||-|||----|||-||||||| 15 [I] COG0183 Acetyl-CoA acetyltransferase
||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||| 14 [GEPR] COG0477 Permeases of the major facilitator superfamily
|||||||||||||--------|----|||-|-----||----|||||-||||-|||---|||||-- 14 [K] COG1522 Transcriptional regulators
---|||--|-||||-----|||----|||||---|-||----|||||-||---|||---|||||-- 14 [I] COG1960 Acyl-CoA dehydrogenases
||||||||||||||||||||||----||||||||||||----||||||||||||||||||||||-- 13 [R] COG0491 Zn-dependent hydrolases, including glyoxylases
|||-|||||||||----|||||--------|-----|-----|||||-|||||||||||||-|--- 13 [C] COG1145 Ferredoxin
||||||--|||||---|-||||----||||-|----||----|||||-||||-||||||||||--- 12 [C] COG0247 Fe-S oxidoreductase
-|-----||---|----------------------------------------------------- 12 [S] COG2880 Uncharacterized protein conserved in archaea
|||||||||||||||-||||||--|||||-||||||-|-||||||||-||-|---|---|||||-- 11 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases
|||||||||||||---||||||----|--|||--||||----|||||-||||||||||||||||-- 11 [R] COG0730 Predicted permeases
|-||--|||----|||-|||-|--||-||-|----|||----|||||-|||||--|||||||||-- 11 [T] COG0784 FOG: CheY-like receiver
|||||||||||||--------------||----------------------------------|-- 11 [R] COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon
|||---|||||||---||------------|---|-----------|---|--------||----| 11 [R] COG1708 Predicted nucleotidyltransferases
---|||--|-|||-------||-----||||---|-||----|||||-||-----|---||||||| 10 [I] COG1250 3-hydroxyacyl-CoA dehydrogenase
||||||||||||||||||||||---|||||||||||||----|||||-||||||||||||||||||  9 [M] COG0438 Glycosyltransferase
||||||||||||||--||||---------------------------------------||-|---  9 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction
|||||||||||||||-||||||||-|||||||||||||----|||||-||||||||||||||||||  9 [R] COG0517 FOG: CBS domain
---|||--|-|||||-|--|||----|||||-|||-||----|||||-||--|--|---|||||||  9 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase
|-||||--|-|||||||-||-|-----||--|--||||----|||||-||-||--||-||||||--  8 [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases
|||||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  8 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins
|||||||||||||-|-|-||-|----||||-|||||||----|||||-||||-|||---|||||||  8 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins
|||||||||||||---||||||----|||||||-||||----|||||-||-|||||--||||||--  8 [K] COG0640 Predicted transcriptional regulators
|-||||||||||||||-|||-|---||||||||||||||||-|||||-||-|||||||-|||||--  8 [V] COG1131 ABC-type multidrug transport system, ATPase component
|||||||||||||||||||||||||-||||||||||||----||||||||||||||||||||||||  7 [QR] COG0500 SAM-dependent methyltransferases
|||||||||||||---||||-|-----||-||--|-||-----------|-----|----|-|---  7 [R] COG0535 Predicted Fe-S oxidoreductases
|-|||||||-|||||||||||||||-|||-||-|||||----||||||||||||||||||||||||  7 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
-||||||||-||-----|------------------------------------------------  7 [M] COG1361 S-layer domain
--||---||-|||---|-------------------------|||||-||||---|--|-|-|---  6 [C] COG0437 Fe-S-cluster-containing hydrogenase components 1
||||||||||||||||||||||---||||||||||||||||||||||-||||||||||||||||||  6 [M] COG0463 Glycosyltransferases involved in cell wall biogenesis
||||||-|||||-----|||-|----|||||-----------|||-|-||--|--|||||||||||  6 [C] COG1146 Ferredoxin
||||||||||-|||--||||-|----|||-||---|||||--|||||-|||-||||||||||||||  6 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component
||------||--------------------------------------------------------  6 [S] COG1417 Uncharacterized conserved protein
--|-||--|----||---||||----|||--|||||-|||--|||||-|||--|||---|||||--  6 [L] COG2801 Transposase and inactivated derivatives
-|---|--|---------------------------------------------------------  6 [S] COG3466 Putative transposon-encoded protein
-----|--|--|------------------------------------------------------  6 [L] COG5558 Transposase
||-||||||||||---|-||-|----|||-------||----|||||-||||---|||||||||--  5 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
|||||||||||||---||||-|---|||||||||||-||-|||||||-||--|--|---|||||--  5 [P] COG0704 Phosphate uptake regulator
-|||--|||-||------||-|---------||---------|||||-||--|--||||-|-|---  5 [R] COG0727 Predicted Fe-S-cluster oxidoreductase
|||||||||||||---|||||---|--||-||--||-|----|||||-|------||||---||--  5 [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit
-|||||||||||-------|----------------------|||||-||---||-----|-|---  5 [C] COG1042 Acyl-CoA synthetase (NDP forming)
-||---|||-||------||-|-----||-----------------|---|-|--|---||-||-|  5 [R] COG1487 Predicted nucleic acid-binding protein, contains PIN domain
|||----|||-|-----|-||---------|-----|---------------------|-------  5 [C] COG1592 Rubrerythrin
-----|--|-||---------|-----||-------------|||-|--|-----|---|||||--  5 [C] COG1804 Predicted acyl-CoA transferases/carnitine dehydratase
---|--|||-|||-----||-------||-|----|||----|||--------------||-|---  5 [K] COG2002 Regulators of stationary/sporulation gene expression
|-||----|-----|-||||-|-----||||---|-||----|||---||-----|---|||||--  5 [T] COG2203 FOG: GAF domain
|||-||-||||||||-||||-|----||||||-|||||----||||||||||||||--||||||--  4 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
||||--|||||||||||-||-|------------|-||----------||---|||---|||||--  4 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
||||||||||------||||||--||||||||||||||-|||||||||||||||||||||||||||  4 [D] COG0206 Cell division GTPase
--||||--|-|||||-|-||||----|||||-----||----|||||-||||||||||||||||--  4 [C] COG0277 FAD/FMN-containing dehydrogenases
-|------|-|||----|||||----|------|---|----|||||--|-----|--|||||---  4 [E] COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
-|------|-|||----|||||-----------|--------|||||--|-----|--|||||---  4 [E] COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
||||||--||||----|||||-------------|-|-----||||||||||-|||--||||||--  4 [O] COG0425 Predicted redox protein, regulator of disulfide bond formation
|||||||||||||||-|||||||||-||||||||||||----|||||-||||||||||||||||||  4 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase
|||||||||-||||||||||||||--|||||||||||||---|||||-||||||||||||||||-|  4 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
|-|||||||-|||||||||||-|||||||||||||||||||||||||-||||||||||||||||||  4 [I] COG0558 Phosphatidylglycerophosphate synthase
-|------|-|||----|||||----|------|---|----|||||--|-----|--|||||---  4 [E] COG0559 Branched-chain amino acid ABC-type transport system, permease components
||||----||||-----||||||||-|||-||||||||----|||||-||-|-|||--||||||--  4 [V] COG0577 ABC-type antimicrobial peptide transport system, permease component
|-|||||||--||||---|-|--|--|------||-||----|||||-||||-||||||||||-||  4 [ER] COG0591 Na+/proline symporter
--||||--|-|||||||-||||---|||||||-||||||||||||||-||||||||||||||||||  4 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 
||||||||||||----|||||||||||---||||||||----|||||-||||||||||||||||||  4 [L] COG0608 Single-stranded DNA-specific exonuclease
-||||||||-|||---------------------------------------|---||-|||||||  4 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis
|||||||||||||||-|||||-----|||||-----------|||-|--|--||||---|||||--  4 [C] COG0644 Dehydrogenases (flavoproteins)
|||-----||-|-||-|---||-----||||--|||||----||-||-||--|--|---|||-|-|  4 [R] COG0655 Multimeric flavodoxin WrbA
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  4 [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit
||||||||||||||||||||||||||||||||||||||-|--||||||||||||||||||||||||  4 [U] COG0681 Signal peptidase I
-|-|----|-|||----|||||----|------|---|----|||||--|-----|--|||||---  4 [E] COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  4 [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit
||||||--|||-|---||||||||---||||------|----|||||-|-------|||-------  4 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes
|||-----||-|----||------------------------------------------------  4 [C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins
|||-|||||||||---||--|------||-||||||------|||||-||||---|----------  4 [O] COG1180 Pyruvate-formate lyase-activating enzyme
|||||||||||||----|---||||-||||||||||||----|||-|-----|---------|---  4 [K] COG1321 Mn-dependent transcriptional regulator
|||||||||||||--------|--------------|-----------------------------  4 [K] COG1378 Predicted transcriptional regulators
|||-|||||||------|------------|-----------------|-----------------  4 [S] COG1433 Uncharacterized conserved protein
--|---|||||||---|||||||||||||-||--||||----|||||-|||||------|||||-|  4 [R] COG1694 Predicted pyrophosphatase
-||---|||---------------------------------------------------------  4 [S] COG1753 Uncharacterized conserved protein
--||||-||-||----|-||-|-----||-----||||----|||||-||||---|||||||||--  4 [H] COG1977 Molybdopterin converting factor, small subunit
-||---|-|---|-----|||------||----|--------|--||-|------|---||-----  4 [JD] COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system
---|----|--|-||-----||----||||----|-|-----|--||-||-----|---|||||--  4 [I] COG2030 Acyl dehydratase
|||-----||--------------------------------------------------------  4 [S] COG2043 Uncharacterized protein conserved in archaea
|-||||-||-|||||-|||||||||-|||||||||||||---|||||-||||-|||||||||||--  4 [P] COG2217 Cation transport ATPase
-|----|||||||----|------------------------------------------------  4 [S] COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
-||-|||||-|-|-----------------|-----------|||---------------------  4 [C] COG2414 Aldehyde:ferredoxin oxidoreductase
-|------|-|||----|||||----|------|---|----|||||--|-----|--|||||---  4 [E] COG4177 ABC-type branched-chain amino acid transport system, permease component
|||-||--||-|-||-||||-|----|||-||--|||||---|||||--|--||||---|||||--  3 [P] COG0004 Ammonia permease
||||--||||--||----||-------||--|---|-|----||||--|-|---------|||---  3 [E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins
-|-|--||||||||||-|||||||--|||-||||||||----|||||-||||||||--||||||--  3 [J] COG0144 tRNA and rRNA cytosine-C5-methylases
|||||||||||||---|-||-|----|||||---||||----|||||-||||---|||||||||--  3 [H] COG0303 Molybdopterin biosynthesis enzyme
|||-----||------||||-|----|||-||---||-----|||||-||||||||---|||||--  3 [E] COG0347 Nitrogen regulatory protein PII
|||||||||||||||-|-||-|||--|||||------|----|||||-||-|||||||||||||||  3 [H] COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases
|||||||||||||||-||||-|----|---|--|---|----|||||--||||--|||||||||--  3 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
|||||||||--|-|||||||||||||----||||||||----|||||-||-|||||||||||||||  3 [R] COG0457 FOG: TPR repeat
||||||||||||||||--||-|----||||------||-----------|-----|--|||-|---  3 [O] COG0464 ATPases of the AAA+ class
||||--|||||||||--|--|---|----|||||||||-||||||||-||----------------  3 [R] COG0622 Predicted phosphoesterase
-|--|||||||||||-||--||-|--||||||||||||----||||||||||||||||||||||||  3 [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases
|||||--||||||---||||||----||||||||||||----|||||-||||||||||||||||--  3 [C] COG0778 Nitroreductase
|-||||||||||||||-|||-|----||||||||||||----|||||-||-||--|||-|||||--  3 [V] COG0842 ABC-type multidrug transport system, permease component
|||-|||||||||----|||||-----||-||-----|----|||-|-||------------|---  3 [C] COG1032 Fe-S oxidoreductase
||-|||--|||||||-||||||||--||||||--||||----|||||-||||||||||||||||||  3 [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
|||||||||||||||||-||-|----------------------------------------|---  3 [R] COG1100 GTPase SAR1 and related small G proteins
||||--|||||||----|||||--|-||||||||||||||||-||-|-|-|----|---|||----  3 [P] COG1122 ABC-type cobalt transport system, ATPase component
||||----|||||---|||||||||||||-||||||||||||||||||||||||||||||||||||  3 [V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component
|||||||||-||-||-------------------------------------------|-------  3 [R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation
|-|||||||--||||-||--|-----|---||-|||||----|||||-||-|---|---||||---  3 [C] COG1454 Alcohol dehydrogenase, class IV
------||||--|----|------------------------------------------|-----  3 [R] COG1483 Predicted ATPase (AAA+ superfamily)
-||-|-|||||||----||-|------||-|-----||-----------|-----|---|||||-|  3 [L] COG1533 DNA repair photolyase
|-|-----|--|-------|||---------------|----|--|--|---|--|----------  3 [H] COG1541 Coenzyme F390 synthetase
|-|||||||||||-----------------------------------------------------  3 [S] COG1602 Uncharacterized conserved protein
||||||--|--||-----||||----|||-||--||||----|||||-||-||--|--|||-||--  3 [K] COG1733 Predicted transcriptional regulators
||-----||--------||||---|--||-|-----------|||-|--|--||||-------|--  3 [C] COG1773 Rubredoxin
|||-----||--------------------------------------------------------  3 [S] COG1810 Uncharacterized protein conserved in archaea
--||||--|--|-||--|-|||----|||-|||-||||-|--|||||-||--|--|---|||||--  3 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family
|||-----||--------------------------------------------------------  3 [C] COG1908 Coenzyme F420-reducing hydrogenase, delta subunit
||||||||||------------||------------------------------------------  3 [S] COG1945 Uncharacterized conserved protein
||||----||-|-------|-|----||||--||||||-|--|||||--|--|--|---|||||--  3 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
--------|-|---------------|||-----|-|-----|||-|--|-----|-----|----  3 [C] COG2181 Nitrate reductase gamma subunit
---|----|---|-----|--|---------------|----------||-|--------||--||  3 [R] COG2358 TRAP-type uncharacterized transport system, periplasmic component
--------|-||---------|--------------||-------||--|-|--------------  3 [Q] COG2368 Aromatic ring hydroxylase
----||--|-|||---------------------|||-----------------------------  3 [S] COG2427 Uncharacterized conserved protein
|||----||-|-----|-----------------|-||----------------------------  3 [S] COG2445 Uncharacterized conserved protein
||||----|---------------------------------------------------------  3 [S] COG2881 Uncharacterized protein conserved in archaea
----||--|-|||---|--------------------|-----------|------------||--  3 [I] COG3255 Putative sterol carrier protein
--|--|--|--|------||-|----|------|---|-----||-|-------||----|-|---  3 [L] COG3335 Transposase and inactivated derivatives
---|----|--|-------|-|---------------|----------------------|-|---  3 [L] COG3415 Transposase and inactivated derivatives
-||-||--|-|||-----------------------------------------------------  3 [K] COG3432 Predicted transcriptional regulator
---|----|----||---------------------------------------------------  3 [R] COG3582 Predicted nucleic acid binding protein containing the AN1-type Zn-finger
---|----|---|--------|---------------|----------||-|--------||----  3 [R] COG4666 TRAP-type uncharacterized transport system, fused permease components
|-|-----|---------------------------------------------------------  3 [K] COG4742 Predicted transcriptional regulator
||||||--|||||||-|-||||----|||||---||||----||||||||--||||---|||||--  2 [H] COG0007 Uroporphyrinogen-III methylase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  2 [I] COG0020 Undecaprenyl pyrophosphate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  2 [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--||||||||  2 [C] COG0045 Succinyl-CoA synthetase, beta subunit
||||---||||||||-||||||---||||-||||||||----|||||-||-|---|--||||||||  2 [P] COG0053 Predicted Co/Zn/Cd cation transporters
||||--||||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  2 [E] COG0065 3-isopropylmalate dehydratase large subunit
|||---||||||-||-||||-|----||||||-|||||----||||||||||||||--||||||--  2 [E] COG0066 3-isopropylmalate dehydratase small subunit
|||||||||||||||-||||-|-----||||---|-||----||||||||--|--|---|||||||  2 [O] COG0071 Molecular chaperone (small heat shock protein)
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--||||||||  2 [C] COG0074 Succinyl-CoA synthetase, alpha subunit
|||||||||||||||-||||||----||||||--||||----||||||||||||||--||||||--  2 [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  2 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase
|||||||||||||||-||||-|----||||||--||||----|||||-|||||--|||||||||--  2 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
|||--|||||||-||-||||-|----|||||--|||||----||||||||||||||--||||||--  2 [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  2 [F] COG0125 Thymidylate kinase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  2 [H] COG0142 Geranylgeranyl pyrophosphate synthase
||||----|||||||-||||||||||||||||||||||||||---|---|---|||||||||||||  2 [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases
|||-|||||||--||||-||----||--------------------------------------||  2 [I] COG0170 Dolichol kinase
|||||||||||||||---||-|----||||----||||----|||||-||-|-|||--||||||--  2 [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
-||---|||--------|---|-----||-||-||||||||||||-|-|------|---||-|---  2 [F] COG0213 Thymidine phosphorylase
|||---|||||||-----------------|-|||-|--||-|||-|-|-||--------------  2 [G] COG0269 3-hexulose-6-phosphate synthase and related proteins
||||||||||||-|---|-|-|||--|||||---||||----||||||||||-||||||||-|---  2 [P] COG0306 Phosphate/sulphate permeases
||||----||--------||----------|----|----------|---|----------|----  2 [P] COG0310 ABC-type Co2+ transport system, permease component
|||-|||||||||---||||-|-----||-|------|----||||||||||||||---|||||--  2 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs
|||||||||||||-||||||||||-||---||||||||----||||||||||||||||||||||||  2 [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase
|-||--|||--||||---||||----||||||||||||----|||||-||||||||--||||||--  2 [E] COG0346 Lactoylglutathione lyase and related lyases
|||||||||||||-----||||----|||-|----|-|----|||-|-||-----|---||||---  2 [H] COG0368 Cobalamin-5-phosphate synthase
|||---|||||-----||||-|--------||--||------|||||-||--|--||||----|--  2 [P] COG0370 Fe2+ transport system protein B
|-|||||||-|||||-||||-|--|-|||||--|||||----|||||-||--||||||||||||--  2 [R] COG0388 Predicted amidohydrolase
||||--||||------||||------|||||---|||-|||||||-|--|--|--|---||||---  2 [S] COG0392 Predicted integral membrane protein
|-||----|----||-|-||-|----|||-||||||||----|||-|-||-|||||--||||||--  2 [T] COG0394 Protein-tyrosine-phosphatase
||||||||||||||||---|----------------------|||||-||----------------  2 [L] COG0417 DNA polymerase elongation subunit (family B)
|||---|||-------|||||---------|-----------|||-|--|-----|----------  2 [C] COG0426 Uncharacterized flavoproteins
---|----|----||---|-|-----|---------------|||||--|---------|-|-|--  2 [C] COG0427 Acetyl-CoA hydrolase
|||---|||||||-|-||||-|-----||-|-----||----|||-|-||---------||-----  2 [S] COG0432 Uncharacterized conserved protein
|||||||||||||---||||-|-----||---|----|----||||---|-|---|---|||||--  2 [R] COG0433 Predicted ATPase
||||||||||||-||-||||||---|||||||-|||||----|||||-||||||||||||||||--  2 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases
||-|--||||------||-|----||-||||-----||----------||-----||||-------  2 [D] COG0455 ATPases involved in chromosome partitioning
||||||||||||||||||||||----|||||||||||||---|||||-||||||||--||||||--  2 [R] COG0456 Acetyltransferases
||||||||||||||||||||||||||||||||||||||--||||||||||||||||||||||||||  2 [O] COG0459 Chaperonin GroEL (HSP60 family)
|||||||||||||||-||||||--||||||||||||||||||||||||||||||||||||||||-|  2 [FE] COG0462 Phosphoribosylpyrophosphate synthetase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  2 [L] COG0468 RecA/RadA recombinase
|||||||||||||||||||||||||-||||-|||||||||||||||||||||||||||||||||||  2 [L] COG0470 ATPase involved in DNA replication
|||-|||||-|||||-|-||-|---|-|||||--||||----|||||-|||-||||||||||||||  2 [P] COG0475 Kef-type K+ transport systems, membrane components
|-|||||||-|||||||-||||----|||||--|||||----|||||-||||||||||||||||--  2 [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
||||||||||||||||||||||----|||||--|||||----|||||-||||||||||||||||||  2 [D] COG0489 ATPases involved in chromosome partitioning
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  2 [E] COG0498 Threonine synthase
|||||||||||||||-||||------||||-------------------|--|--|---|||||--  2 [H] COG0499 S-adenosylhomocysteine hydrolase
|||||||||||||||||-||||----|||||-||-|||----||||||||||||||||||||||--  2 [O] COG0501 Zn-dependent protease with chaperone function
|||---|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||--  2 [I] COG0511 Biotin carboxyl carrier protein
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  2 [F] COG0518 GMP synthase - Glutamine amidotransferase domain
|||||||||||||||--|||-|----||||||||||||----|||||-|||||--|---|||||--  2 [G] COG0524 Sugar kinases, ribokinase family
||||||--||||||||--|||-||--|||||||||||||||||||||-|||||--|---|||||||  2 [E] COG0531 Amino acid transporters
-||-----||-------|||||||--|---|--||-||----||||---|||---|---|||||--  2 [P] COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
-||||||||-|||----|||||----|---|||||||||---|||||-||||---|||||||||--  2 [P] COG0609 ABC-type Fe3+-siderophore transport system, permease component
-||||||||-|||----|||||----||||||||||||----|||||-||||---|||||||||--  2 [P] COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component
||||--||||-||----|||||----||||||||||||||||-||-|---|--------|||----  2 [P] COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K
||||||||||||||||-----------|||------------------------------------  2 [O] COG0638 20S proteasome, alpha and beta subunits
-|||||||||||||||-|||||--------||-|-|||----||||||||||||||--|||-||--  2 [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
|||---||||-|----|-||----------|-----------|||-|---------|||-------  2 [C] COG0680 Ni,Fe-hydrogenase maturation factor
-||-----||---||--|||||||--|---|--||-||----||||--||||---|---|||||--  2 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
|||||||||||||||--||||---------|-------------------------|||-------  2 [C] COG0731 Fe-S oxidoreductases
|||||||||||||---||||||||||||||||||||||----|||||-||||||||||||||||||  2 [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1
--||||--|-|||---|-||-|----||||----||||----|||||-||||||||||||||||||  2 [U] COG0805 Sec-independent protein secretion pathway component TatC
--||----|----|||||-||-||||||||||||||||||||||||||||||-|||||||||||||  2 [C] COG0822 NifU homolog involved in Fe-S cluster formation
--|-----|-|-|----||||||||-||||||||||||----|||||-||||-|||||||||||||  2 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
--||--|||--------|||-|--||----|----|||----|||||-||--|--||||||-||--  2 [NT] COG0840 Methyl-accepting chemotaxis protein
------||||||||||||--||----|||||-|-||||-|--|||||-||-|---||||----|--  2 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family
-|||---||--|----|-||------|||---|---||----|||||-||-||--|--||||||||  2 [M] COG1004 Predicted UDP-glucose 6-dehydrogenase
|||-----||--------------------------------------------------------  2 [C] COG1029 Formylmethanofuran dehydrogenase subunit B
-|||--||||-------|------||-----------|-----------|--------|-------  2 [R] COG1033 Predicted exporters of the RND superfamily
|||||||||-|||-----|--|-----||--|----------|||||---||---|----------  2 [H] COG1056 Nicotinamide mononucleotide adenylyltransferase
--------|---|||--|||----|||||-||-|||||----|||||--|||---|---||||---  2 [G] COG1070 Sugar (pentulose and hexulose) kinases
--||---||---||||-|-|||||--|||-|||--|||----|||||-||-||--|---|||||--  2 [R] COG1073 Hydrolases of the alpha/beta superfamily
|||---||||-|-----|||------|||||-|-||||----|||||--|-----|---|||||--  2 [G] COG1082 Sugar phosphate isomerases/epimerases
|||-----||--------------------------------------------------------  2 [R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes
--|-----|----||||||||||||-||||||||||||----||||||||||-|||||||||||||  2 [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes
|||||-||||-|-||||||-|------||||---|---|||||||-|--|--|---|--------|  2 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits
-||-||--||||-----|||||||--|---|--||-||----||||---||||--|---|||||--  2 [P] COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component
-||||||||--||----|||||----|---|-|||||||-|||||||-||||---|||||||||--  2 [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components
--|-----|-------|-||------|||||||-||||--------|-||-||||---|-||||||  2 [GM] COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component
|||-||||||||----||--------------------------------------||--------  2 [C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit
|||---||||-------|------------------------------------------------  2 [C] COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain
|||-----||--------------------------------------------------------  2 [C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit
--------|----------|||-----||-|||||||-----|||||--|-----|||-||||---  2 [E] COG1174 ABC-type proline/glycine betaine transport systems, permease component
|||||||||||||------|------|||-------------|||----|-----|---|||||--  2 [R] COG1201 Lhr-like helicases
|||---|||-|||---||--|-----------|----|----|||||----|--------------  2 [R] COG1203 Predicted helicases
|-----|||---|---|---|----------------------------|--------|----|--  2 [M] COG1213 Predicted sugar nucleotidyltransferases
|-|-||||||||-||||-||------|---|||-||||----|||||--|-----|---|||||-|  2 [M] COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
|-|--||||---|-----||-|----|||||-----------|---|--||-|--|---||-||--  2 [R] COG1216 Predicted glycosyltransferases
||||||||||||||||-|||-|||||||||||||||||----|||-|----|---|------||--  2 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
-||||||-|-||||||--||-|--------------------------||-----|---||-||--  2 [J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing
|||---||||-------|------------|---------------|-------------------  2 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II
--||||--|-------|-||--||--|||--|--||||----|||||-||||---|--||||||||  2 [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1
|||||||||||||||---||-|--||||||-||||||-----|||||-||||-||----|||||||  2 [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
|-|---||||||----||||-|-----||||----|||-----------||||--|---||-||--  2 [E] COG1305 Transglutaminase-like enzymes, putative cysteine proteases
--|||||||||||||-||-|-|--|||||-||||||||----|||||-||--||||--||||||--  2 [Q] COG1335 Amidases related to nicotinamidase
|||--|--||||-----|-||------||---|----|----------------------------  2 [L] COG1343 Uncharacterized protein predicted to be involved in DNA repair
|||-||||||---||-||--||-----||-||--||||----|||||-|-----------|-----  2 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family
|||---|||--|-----|---|||------|---|||-----------||||---|---||-|---  2 [P] COG1392 Phosphate transport regulator (distant homolog of PhoU)
--||----|-|-|||||-||||----|||||-||--||||------|-||--||||--|||-|---  2 [O] COG1404 Subtilisin-like serine proteases
|||||||||||||----------------------------------------------|||||--  2 [R] COG1407 Predicted ICC-like phosphoesterases
||||||||||------||--||--||----|||||||||-|||||-|---------|||||-----  2 [R] COG1418 Predicted HD superfamily hydrolase
||||||||||||||||--------------------------------------------------  2 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit
|||---|||-|||---||-||-----------|----|----------------------------  2 [L] COG1468 RecB family exonuclease
|-|||||||-||||||--------------------------------------------------  2 [LO] COG1474 Cdc6-related protein, AAA superfamily ATPase
||||---||----------|-|--------||||||||-----------|-------------|--  2 [K] COG1476 Predicted transcriptional regulators
|||-|||-|||||---||-||------||---|--|-|----|||||----|--|---|-------  2 [L] COG1518 Uncharacterized protein predicted to be involved in DNA repair
|-|---|||----------|----------------------------------------------  2 [S] COG1572 Uncharacterized conserved protein
||--|||||||||-----------------------------------------------------  2 [K] COG1581 Archaeal DNA-binding protein
||||||||||-|||||--------------------------------------------------  2 [L] COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
|||-----||-------|||----------|-----------------------------------  2 [R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily
---|----|-||||--|-||-|----||||----||||----||||||-|--|--|---|||||||  2 [C] COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2
||||--|||-|||----|---|--------||-|||||--------------|----------|--  2 [CP] COG1668 ABC-type Na+ efflux pump, permease component
-||||||||--||-----------------------------------------------------  2 [N] COG1681 Archaeal flagellins
--|-----|-------|-||------|||||||-||||--------|-||-||||---|-||||||  2 [GM] COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component
|-|||||||-|||----|-|||----||||||||||||----|||||-|------|------||--  2 [K] COG1695 Predicted transcriptional regulators
||||--|||||||----|------------------------|||||-||||-||-------||--  2 [S] COG1720 Uncharacterized conserved protein
||||----||--------------------------------------------------------  2 [R] COG1745 Predicted metal-binding protein
|||---||||||------------------------------------------------------  2 [R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)
-|------||----------|---------|-----------|||---------------------  2 [E] COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB
|||||||||||||||||----------||-------||----------|||--||---|||-||--  2 [L] COG1793 ATP-dependent DNA ligase
||--|||||||||||--|---||---|----|-----------------|------------||--  2 [S] COG1814 Uncharacterized membrane protein
--||||--|||||---|-||-|----||||----||||----|||||-||||||||||||||||||  2 [U] COG1826 Sec-independent protein secretion pathway components
||||--||||-||---|--|--||------------------|||||----|-------||-|---  2 [G] COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes
-||---|||---------||----------------|-----------------------|-|---  2 [G] COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit
|-|-|-|||-|||-|-||||||----||||||-|||||----|||||--|-|-|||---|||||||  2 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family
|||---|||-|||---|---|---------------------------------------------  2 [L] COG1857 Uncharacterized protein predicted to be involved in DNA repair
--|-|||||||-|||-----||--------------------|||----|---------|------  2 [J] COG1859 RNA:NAD 2'-phosphotransferase
||||||||||--------------------|-----||----------------------------  2 [S] COG1873 Uncharacterized conserved protein
|||-----||--------------------------------------------------------  2 [C] COG1880 CO dehydrogenase/acetyl-CoA synthase epsilon subunit
---||||||--||--------|----||||-------|----|||----------|---|||||--  2 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit
||||||||||||||||---|-------------------------------------------|--  2 [O] COG1899 Deoxyhypusine synthase
||||--||||||||||--------------------------------------------------  2 [L] COG1948 ERCC4-type nuclease
|-||||||||||||||--------------------------------------------------  2 [K] COG1958 Small nuclear ribonucleoprotein (snRNP) homolog
|||---||||--|-----------------|---||||----|||||--|-|--------------  2 [R] COG1988 Predicted membrane-bound metal-dependent hydrolases
|-|-----|--------|||----------------------------------------------  2 [S] COG2006 Uncharacterized conserved protein
|||---|||--------|------|-----|-----------------------------------  2 [C] COG2033 Desulfoferrodoxin
|||-||||||-||-----------------------------------------------------  2 [S] COG2034 Predicted membrane protein
||||--||||---|||--------------------------------------------------  2 [B] COG2036 Histones H3 and H4
|||-----||--------------------------------------------------------  2 [C] COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase
||------||||----|--------------------------------|----------------  2 [R] COG2044 Predicted peroxiredoxins
|||-----||-|----|-||--------------------------------------|-------  2 [C] COG2048 Heterodisulfide reductase, subunit B
--|||||||-||--|-|----|----|||--|||||||----|||||-||||---|||||||||--  2 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism
|||||||||||||-------------||--|--------------|---|-|---|---||-||--  2 [NU] COG2064 Flp pilus assembly protein TadC
||||----||---------|------|----|--------------------|--|---||-|---  2 [R] COG2085 Predicted dinucleotide-binding enzymes
||||||||||||||||--------------------------------------------------  2 [R] COG2102 Predicted ATPases of PP-loop superfamily
---||||||--||-------||----||||-------|----|||----------|---|||||--  2 [I] COG2185 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)
|-|-|||||------------|--------------------------------------------  2 [C] COG2191 Formylmethanofuran dehydrogenase subunit E
--||||--|-||----|---|-------------|-|-----------------------------  2 [S] COG2210 Uncharacterized conserved protein
||||||||||||||---|||||----|||-|-||||||----|||||-||-||--|--|||||--|  2 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold
|||-----|||-------------------|---------------|-------------------  2 [C] COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits
--|||||||-|||||----|----|||--------------------------||||||-------  2 [R] COG2236 Predicted phosphoribosyltransferases
---|---||-|-----|-||-------|--------------------------------------  2 [R] COG2402 Predicted nucleic acid-binding protein, contains PIN domain
--------|---|-----||----------------------------------------------  2 [R] COG2405 Predicted nucleic acid-binding protein, contains PIN domain
------|||||-|-----------------------------------------------------  2 [S] COG2411 Uncharacterized conserved protein
||||--|||||||-|--|------------------------|||||-||--||||||||||||--  2 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase
||||||||||||||||--------------------------------------------------  2 [R] COG2520 Predicted methyltransferase
--||--|||-|||-----------------------------------------------------  2 [R] COG2522 Predicted transcriptional regulator
--|-----|-------|-||-|--------------|-----------||-----|---||-|---  2 [T] COG2770 FOG: HAMP domain
-|||----|-------|----|--||----|-----||----|||||-||||||||||||||||||  2 [M] COG2834 Outer membrane lipoprotein-sorting protein
---|--|||-|-|-----||----------------------------------------------  2 [S] COG2886 Uncharacterized small protein
-|-|----|-------|---------|-------||---------|------|--------|||--  2 [L] COG3316 Transposase and inactivated derivatives
-|||----||-|------------------------------------------------------  2 [K] COG3355 Predicted transcriptional regulator
-|||----||--------------------------------------------------------  2 [S] COG3366 Uncharacterized protein conserved in archaea
----|||||--|------------------------------------------------------  2 [R] COG3368 Predicted permease
---|||--|-||------------------------------------------------------  2 [R] COG3413 Predicted DNA binding protein
||||||||||||||||---------|-----||||||--------|-----------------|--  2 [I] COG3425 3-hydroxy-3-methylglutaryl CoA synthase
|||-|||||||||---||---|--------------------------------------------  2 [G] COG3635 Predicted phosphoglycerate mutase, AP superfamily
|||-----||--------------------------------------------------------  2 [D] COG3640 CO dehydrogenase maturation factor
--|-----|---------------------------------------------------|-|---  2 [R] COG3894 Uncharacterized metal-binding protein
-||-----|---------------------------------------------------------  2 [S] COG4818 Predicted membrane protein
--|----||---------------------------------------------------------  2 [S] COG4854 Predicted membrane protein
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  2 [E] COG4992 Ornithine/acetylornithine aminotransferase
|-|-----|-----------|---------------------------------------|-|---  2 [R] COG5012 Predicted cobalamin binding protein
--||----|---------------------------------------------------------  2 [S] COG5427 Uncharacterized membrane protein
---|----|---------------------------------|||-|-------------------  2 [C] COG5557 Polysulphide reductase
-------||---------|-----------------------------------------------  2 [S] COG5559 Uncharacterized conserved small protein
------|||----------------------------------------|----------------  2 [S] COG5608 Conserved secreted protein
||||||--|||||-|-|-||||||--|||||---||||----|||||-||-|||||||||||||--  1 [H] COG0001 Glutamate-1-semialdehyde aminotransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase
|||||||||||||||-||||-------||||-||-|||----|--||--|--|------||-|---  1 [F] COG0005 Purine nucleoside phosphorylase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [E] COG0006 Xaa-Pro aminopeptidase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||---|||||||  1 [J] COG0009 Putative translation factor (SUA5)
|||||||||||||||---||||--------|-|-|-||----|||-|-||-|||||||-||||---  1 [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family
||-||||||||--|--|||-------|||-|--||-||----------------------------  1 [S] COG0011 Uncharacterized conserved protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0012 Predicted GTPase, probable translation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0013 Alanyl-tRNA synthetase
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0015 Adenylosuccinate lyase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit
||||||||||||||||--||||--||----|||||||||||||||||||-|||-------------  1 [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0018 Arginyl-tRNA synthetase
|||-||--||---||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0019 Diaminopimelate decarboxylase
|||||||||||||||---||----------------------|||||-||||--------------  1 [J] COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [J] COG0024 Methionine aminopeptidase
||||||-|||---|||--||-|----|||--|-||||-----|||||-||-||------|--|---  1 [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0030 Dimethyladenosine transferase (rRNA methylation)
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase
-|||||||||-||||-|-||||----|||-||||---|----|||||-|-||-|||---|-|||--  1 [P] COG0038 Chloride channel protein EriC
||||||--|||||||-||||||||-|||||||||||||-||||||||-|-|||--|--||||||||  1 [C] COG0039 Malate/lactate dehydrogenases
||||----||||-||-||||-|----||||||--||||----|||||||||||||---||||||--  1 [E] COG0040 ATP phosphoribosyltransferase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
||||----||---|||||||||||||||||||||||||----|||||-||||||||||||||||||  1 [J] COG0042 tRNA-dihydrouridine synthase
|||||||||||||||-||||||----||||||||||||----|||-|--|--|--|||||||||--  1 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0048 Ribosomal protein S12
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0049 Ribosomal protein S7
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0051 Ribosomal protein S10
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0052 Ribosomal protein S2
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0054 Riboflavin synthase beta-chain
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||--  1 [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
|||----|||||-|--||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EH] COG0059 Ketol-acid reductoisomerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0060 Isoleucyl-tRNA synthetase
|||||||||||||||||||||---|||||||||||||||-||||||||||||||||||||||||||  1 [G] COG0061 Predicted sugar kinase
|||||||||||||||-||||-|----|||||-----------|||||-||--|--|||||||||--  1 [S] COG0062 Uncharacterized conserved protein
||||||||||||||||||||-|----||||||--|||-----|||||-||--||||||||||||--  1 [G] COG0063 Predicted sugar kinase
||||----||-||||-||||||||||||||||||||||||||-------|---|||||||||||||  1 [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0067 Glutamate synthase domain 1
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0068 Hydrogenase maturation factor
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0069 Glutamate synthase domain 2
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0070 Glutamate synthase domain 3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [R] COG0073 EMAP domain
||||||||||||||--||||-|--------||--|-||--------|-||------||-||-||--  1 [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase
||||||--||||-||-||||-|----||||||-|||||----|||-||||||||||--||||||--  1 [E] COG0077 Prephenate dehydratase
|||||||||||||||-||||-|---|||||||||||||--|-||||||||||||||--||||||--  1 [E] COG0078 Ornithine carbamoyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0080 Ribosomal protein L11
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0081 Ribosomal protein L1
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0082 Chorismate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0087 Ribosomal protein L3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0088 Ribosomal protein L4
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0089 Ribosomal protein L23
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0090 Ribosomal protein L2
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0091 Ribosomal protein L22
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0092 Ribosomal protein S3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0093 Ribosomal protein L14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0094 Ribosomal protein L5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0096 Ribosomal protein S8
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0097 Ribosomal protein L6P/L9E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0098 Ribosomal protein S5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0099 Ribosomal protein S13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0100 Ribosomal protein S11
|||||||||||--||||||||||||||||||||||||||-||||||||||||||||||||||||||  1 [J] COG0101 Pseudouridylate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0102 Ribosomal protein L13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0103 Ribosomal protein S9
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0104 Adenylosuccinate synthase
|||||||||||||||||-||-||||||||||--|||||----|||||-||||||||||||||||||  1 [F] COG0105 Nucleoside diphosphate kinase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0107 Imidazoleglycerol-phosphate synthase
---|||--|-|||||-|-||-|----||||----||||----||||||-|--|--|---|||||||  1 [O] COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor)
||||||||||||||||||||-|||||||||||||||||-|||||||||||||||||||||||||||  1 [E] COG0112 Glycine/serine hydroxymethyltransferase
||||||--|||||||-|-||||||--|||||---||||----|||||-||-|||||||||||||||  1 [H] COG0113 Delta-aminolevulinic acid dehydratase
||||----|||--||-||||||----||||||||||||----|||||-||||||||||||||||||  1 [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
-|----|||||-|-----|-||--------||||||||----||||||||||||||----------  1 [L] COG0116 Predicted N6-adenine-specific DNA methylase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0118 Glutamine amidotransferase
||||||||||||||||--||-|||||----||||||------||||||||||||||---|||||--  1 [G] COG0120 Ribose 5-phosphate isomerase
|-||--|||---||||--|--|-----||-|-----||-|--|||||-||--|--|---|||||--  1 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0124 Histidyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0126 3-phosphoglycerate kinase
||||||||||||||||||||||||||||||||||||||----|||||-||||||||--||||||--  1 [F] COG0127 Xanthosine triphosphate pyrophosphatase
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase
|||----||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase
||||||||||||||||||||||||||||||||||||||||--||||||||||||||--||||||||  1 [J] COG0130 Pseudouridine synthase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0131 Imidazoleglycerol-phosphate dehydratase
||||---|||---||-|||||||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0133 Tryptophan synthase beta chain
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0134 Indole-3-glycerol phosphate synthase
||||||-||||||||-||||-||---|---||-|||||----||||||||||||||||||||||--  1 [E] COG0135 Phosphoribosylanthranilate isomerase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0136 Aspartate-semialdehyde dehydrogenase
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0137 Argininosuccinate synthase
--||||--|----||-||||||----||||||-|||||----||||||||||||||--||||||--  1 [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0139 Phosphoribosyl-AMP cyclohydrolase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0141 Histidinol dehydrogenase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0143 Methionyl-tRNA synthetase
-||--|--|||||||-|-||-------|-------|-|------------------||-|||||--  1 [EQ] COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0148 Enolase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0149 Triosephosphate isomerase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0150 Phosphoribosylaminoimidazole (AIR) synthetase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||||||||||--  1 [F] COG0151 Phosphoribosylamine-glycine ligase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||||  1 [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
--------|-||-||-|-||-|----|||-|-----||----||||||||--||||---|||||--  1 [P] COG0155 Sulfite reductase, beta subunit (hemoprotein)
||||--||||||-|--|||||-----|||||-||-|||----|||||-||||||||||-||-||--  1 [H] COG0157 Nicotinate-nucleotide pyrophosphorylase
||||||-||||||||-||||-||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0159 Tryptophan synthase alpha chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0162 Tyrosyl-tRNA synthetase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase
||||||||||||||||||||||||-|||||||||||||----|||||-||||||||||||||||||  1 [L] COG0164 Ribonuclease HII
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0165 Argininosuccinate lyase
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0167 Dihydroorotate dehydrogenase
||||--||||--|||-||||||--||------||||||-||||||||-||||-||---||||----  1 [P] COG0168 Trk-type K+ transport systems, membrane components
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0169 Shikimate 5-dehydrogenase
|||||||||||||||-||||||--||||||||||||||||||||||||||--||||||||||||--  1 [H] COG0171 NAD synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0172 Seryl-tRNA synthetase
|||||||||||||||-||||-|----||||-|||||||----|||||-||||||||||||||||||  1 [E] COG0174 Glutamine synthetase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [L] COG0177 Predicted EndoIII-related endonuclease
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0180 Tryptophanyl-tRNA synthetase
||||||--|||||||-|-||||||--|||||---||||----||||||||-|||||||||||||||  1 [H] COG0181 Porphobilinogen deaminase
|||-|||||||||||-|||||---------------|------------|--|-------|-|---  1 [J] COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0184 Ribosomal protein S15P/S13E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0185 Ribosomal protein S19
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0186 Ribosomal protein S17
--||||--|----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
--||||--|----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
-|||--|||-|||-----||-|---------------|--||||||||||||||||---|||||--  1 [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0195 Transcription elongation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0197 Ribosomal protein L16/L10E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0198 Ribosomal protein L24
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0199 Ribosomal protein S14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0200 Ribosomal protein L15
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0201 Preprotein translocase subunit SecY
||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit
|||-----||---|||----||----||||||||||||-|||||||||||||||||---|||||--  1 [F] COG0207 Thymidylate synthase
|-|||||||-|||||||||-|||||-||||||||||||-|||||||||||||||||||||||||||  1 [F] COG0209 Ribonucleotide reductase, alpha subunit
|||||||||||||||--|--||----|||||--|||||------------||--------------  1 [H] COG0214 Pyridoxine biosynthesis enzyme
--|||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0215 Cysteinyl-tRNA synthetase
-|||--||||---|--||--|---------||||||||||||||||||||||||||||||||||||  1 [R] COG0218 Predicted GTPase
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG0226 ABC-type phosphate transport system, periplasmic component
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)
||||-||||||-|||-||-||------||||-||-|||-||-|||||-|||||--|||--||||||  1 [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  1 [H] COG0237 Dephospho-CoA kinase
|-------|----|||||||||||||||||||||||||||--|||||-||||||||||||||||||  1 [C] COG0240 Glycerol-3-phosphate dehydrogenase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0244 Ribosomal protein L10
|||||||||||||-|-||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0250 Transcription antiterminator
|||||||||||||||-----||----||||||||||||----|||||-|||-||||||||-|----  1 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D
||------||------|||||-||--|||||---||||----||||||||||||||||||||||||  1 [E] COG0253 Diaminopimelate epimerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0255 Ribosomal protein L29
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0256 Ribosomal protein L18
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI)
--|||||||-|||||--|||-|----|||-|||-||||----|||||-||||||||--||||||||  1 [C] COG0281 Malic enzyme
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0284 Orotidine-5'-phosphate decarboxylase
||||---||----------|-------||--|||||--|||-|||-|-|||||||||||-||-|-|  1 [V] COG0286 Type I restriction-modification system methyltransferase subunit
||||||--|||||||-||||-|----||||||-|||||----|||||-||||||||||||||||--  1 [E] COG0287 Prephenate dehydrogenase
|||-----||------||||--||--|||-||-|||||----||||||||||||||||||||||||  1 [E] COG0289 Dihydrodipicolinate reductase
||||||--||---|||--------||----------------||||||||||||||---|||||||  1 [J] COG0293 23S rRNA methylase
|||||||||||||||-||||||||--||||||||||||----|||||-||||||||||||||||-|  1 [H] COG0294 Dihydropteroate synthase and related enzymes
|||---||||--------||----------|-----------|||-|---|-----|||-------  1 [O] COG0298 Hydrogenase maturation factor
|||||||||||||----|------|-----|||||||||||||||||-||||--------------  1 [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase
|||||||||||||---|-||----------|-----------|||-|---------|||-------  1 [O] COG0309 Hydrogenase maturation factor
|||||||||||||||--|---|----|||||--|||||------------||--------------  1 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis
|||||||||-|||---|-||-|----|||-----||||----|||||-||||---|||||||||--  1 [H] COG0314 Molybdopterin converting factor, large subunit
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [H] COG0315 Molybdenum cofactor biosynthesis enzyme
||||--||||---|||---|||||||||-|||||||||||--||||||||||-||||||-------  1 [S] COG0327 Uncharacterized conserved protein
|||||||||||||---|||||-||--||||||||||||----||||||||||||||||||||||||  1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase
|||||||||||||||-||||||--||||||||||---|-|--||||||||||||||||||||||||  1 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs
--|||||||-|||||--|||||||--|---|--|||||----|||||--|||-|||||--||-|--  1 [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase
||||--|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||||  1 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase
-||-||--||-|------||----------|-----------|||-|-||||-|||||||||||--  1 [C] COG0348 Polyferredoxin
||||||||||||||--||-||-|||-||||||-|||||-|--|||||-||||||||||||||||-|  1 [L] COG0350 Methylated DNA-protein cysteine methyltransferase
|||||||||||||||-||-|||--|-||||||||||||----|||||-||||||||||||||||--  1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
--|-|||||----||-|-||||----||||||-|||||----|||||-||||||||||||||||--  1 [H] COG0352 Thiamine monophosphate synthase
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0358 DNA primase (bacterial type)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0361 Translation initiation factor 1 (IF-1)
|||||||||||-||||----------||||||---|||----|||||-||--|-------|-|---  1 [E] COG0367 Asparagine synthase (glutamine-hydrolyzing)
|||||||||||||-|--|||----------||||-|||----|||||-------------|-----  1 [C] COG0371 Glycerol dehydrogenase and related enzymes
|-||||--|-|||||-||||-|----||||-|--||||----|||||-||-|||||||||||||||  1 [C] COG0372 Citrate synthase
||||||--|||||---|-||||||--|||||---||||----|||||-||-||||||||-------  1 [H] COG0373 Glutamyl-tRNA reductase
--|-----||------|--|----------|-----------|||-|---------|||-------  1 [C] COG0374 Ni,Fe-hydrogenase I large subunit
|||---||||------|-||-|--------------------|||-|---------|||-------  1 [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)
--||----|----|----|--------||--------|----|||||-|---|--|---||-||--  1 [P] COG0376 Catalase (peroxidase I)
--|||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases
|||-----||----|-|-||||----|||-----|--||---|||||--||----||||||||---  1 [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase
||||--||||||----|||||-----|||||----|||----|||||-||--||||||-||-||--  1 [H] COG0379 Quinolinate synthase
||||----||---|--||||-|----||||||||||||----|||||-|--|--------------  1 [S] COG0391 Uncharacterized conserved protein
|||||||||--|-----|||-------|||-|---|-|----|||-|-|--|-----------|--  1 [S] COG0393 Uncharacterized conserved protein
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0409 Hydrogenase maturation factor
||||||||||||||||||||||--||----||--|||-----|||||-||----------------  1 [L] COG0419 ATPase involved in DNA repair
||||||||||||||||||||||--||||||||--||||----|||||-||----------|-----  1 [L] COG0420 DNA repair exonuclease
-|--|||||||||||-||---|----|---|--|--||----||||||-|--||||||----|---  1 [E] COG0421 Spermidine synthase
||||---|||||----||||||----|||||-----||----|||||-||--||||--|||-||--  1 [H] COG0422 Thiamine biosynthesis protein ThiC
||||||||||||||||-----|--|||||||---|---||||------------------------  1 [J] COG0423 Glycyl-tRNA synthetase (class II)
||||--|||||||||||--|----------------------|||-|--|-----|----------  1 [A] COG0430 RNA 3'-terminal phosphate cyclase
-|-|--|||||-|-----||----------------------|---|------------|--|---  1 [R] COG0434 Predicted TIM-barrel enzyme
|||-----|--|-||-|-||-||||--||-||||||||----|||||-||||||||||||||||--  1 [I] COG0439 Biotin carboxylase
|||---||||--|||-||||-|----||||||-|||||----||||||||||-|||--||||||--  1 [E] COG0440 Acetolactate synthase, small (regulatory) subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0441 Threonyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0442 Prolyl-tRNA synthetase
--|||||||-|||---||--||||-||---|||||||||||||||||-||||---||||||||---  1 [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
---|----|---------||------||||-|--|||-----|||||-|-||--------------  1 [H] COG0447 Dihydroxynaphthoic acid synthase
|||-|||||-|||||||||||||||--|||-||-||||----||||||||-||--|||||||||||  1 [O] COG0450 Peroxiredoxin
|||||||||||||||-||||||---|||||||||||||----|||||-||||||||||||||||--  1 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  1 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0460 Homoserine dehydrogenase
|||||||||||||||-||||||-|--||||||||||||----||||||||||||||||||||||--  1 [F] COG0461 Orotate phosphoribosyltransferase
|||---||||||-||-||||-|----||||||--||||----||||||||||||||--||||||||  1 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase
-|||--||||||||||--------------------------------------------------  1 [T] COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||||||||||||  1 [C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0480 Translation elongation factors (GTPases)
||||--||||||||--||||-|---|||||-|||||||----|-||||||||||||--||||||||  1 [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
--------|-------|----|-----||||||---|-----------------------------  1 [P] COG0490 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels
||||||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0492 Thioredoxin reductase
|-||||--|-|||||||||||||||-||||||||||||----||||||||||||||||||||||||  1 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0495 Leucyl-tRNA synthetase
||||----|||-||--||||-||||-----------------|||||-||||||||||||||||--  1 [R] COG0496 Predicted acid phosphatase
||||||||||||||||||||-|||||||||||||||||||--||||||||||||||||||||||||  1 [F] COG0504 CTP synthase (UTP-ammonia lyase)
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  1 [EF] COG0505 Carbamoylphosphate synthase small subunit
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II
|||-||--|--|-||||-||||--|-||||||||||||||||||||||||||||||||-|||||||  1 [LKJ] COG0513 Superfamily II DNA and RNA helicases
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0519 GMP synthase, PP-ATPase domain/subunit
|||||||||||||---|--|-|----|||||---||||----|||||-||||---|||||||||--  1 [H] COG0521 Molybdopterin biosynthesis enzymes
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0522 Ribosomal protein S4 and related proteins
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0525 Valyl-tRNA synthetase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0527 Aspartokinases
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0528 Uridylate kinase
-------||---|||-|-|--|-----||-|-----||----||||||||--|--|--|-||||--  1 [P] COG0529 Adenylylsulfate kinase and related kinases
||||||||||||-||-|||-----||-----------|----|||||-|--|--------|-----  1 [P] COG0530 Ca2+/Na+ antiporter
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0532 Translation initiation factor 2 (IF-2; GTPase)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0533 Metal-dependent proteases with possible chaperone activity
||||--|||---|||-|||-||--|||||-|||||||||||||||||-||||||||||||||||--  1 [V] COG0534 Na+-driven multidrug efflux pump
|||||||||-|||||||-||||||-|||||||||||||||||||||||||||||||||||||||||  1 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
---|||--|-|||||-||||-|-----||--|--||||----|||||--|-|---|||-|||||--  1 [C] COG0538 Isocitrate dehydrogenases
|||||||||||||||-||||||----||||||||||||----||||||||--||||||||||||--  1 [F] COG0540 Aspartate carbamoyltransferase, catalytic chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0541 Signal recognition particle GTPase
|||-||||||-|-||-||--|---|-|||-||-|-|||----|||||-||---|||---|----||  1 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
|-||--|||----|--|-||-|--|||||-|||||||||---|||||-||||||||||||||||--  1 [R] COG0546 Predicted phosphatases
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0547 Anthranilate phosphoribosyltransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||-|  1 [E] COG0548 Acetylglutamate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0550 Topoisomerase IA
|||||||||--------|--|-|||-----|||||||||-|||||||||||||||||||-------  1 [L] COG0551 Zn-finger domain associated with topoisomerase type I
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0552 Signal recognition particle GTPase
--||-||||--|||||-|||||||--|||-||||-|||--|||||||-|||||-------|-----  1 [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
---|||-||--|||--||||||---|||||||||||||-||||||||-|||||--|---|||||--  1 [C] COG0554 Glycerol kinase
||||||||||||------||-|-----||-|------|----|||||-||||||||---|||||--  1 [O] COG0555 ABC-type sulfate transport system, permease component
|||||||||||-|||-----|--|--||||||----------|||||-||||||||||||||||--  1 [E] COG0560 Phosphoserine phosphatase
|-||||||||||||||-||||||||||||||||||||||||||||||||-||-|||---||-|---  1 [R] COG0561 Predicted hydrolases of the HAD superfamily
--||--|||----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0563 Adenylate kinase and related kinases
||||||--||-||-----||-|--------------------|||||-||||||||---|||||-|  1 [J] COG0565 rRNA methylase
--------|----||-|||||||||||||||||||||||||||||||-||||||||||||||||||  1 [J] COG0566 rRNA methylases
||||--|||||-|---||||||--||-||---||||||-||||||||-||||-||---||||----  1 [P] COG0569 K+ transport systems, NAD-binding component
||||---||||||---||||-|---||||||||||||||-|||||||-|-|||--|--||||||--  1 [P] COG0573 ABC-type phosphate transport system, permease component
|||||||||||||---||||||--|-|||||--|-||-----|||||-||--||||||||||||||  1 [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [I] COG0575 CDP-diglyceride synthetase
----|--||---|----||||-----|||-|---|--|-||||||-|-||--||||||||||||--  1 [R] COG0579 Predicted dehydrogenase
|-------|--|-|||-||-||---|----||||||||-|||||||||-||||--|---|||||--  1 [G] COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG0581 ABC-type phosphate transport system, permease component
|||||||||--||---||||||||--||||||||||||||--|||||-||||||||||||||||||  1 [L] COG0582 Integrase
||------||------|-||||----||||||||||||----|||||-||||||||--||||||--  1 [K] COG0583 Transcriptional regulator
|||||||||||||||||----|--------------------|||||-||||----|||-------  1 [S] COG0585 Uncharacterized conserved protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
-||---|-|-||-||-||||||----|||||||||||-----|||||-|||||--|||||||||-|  1 [P] COG0598 Mg2+ and Co2+ transporters
|||-||--||-|-||--||--|----|||--|---|||-------|---||-||||---|||||--  1 [S] COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
--|||||||-|||---||||||||-||||||||||||||||||||||-||||---||||||||---  1 [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
||||||||||||----|-|||---------||||||||----|||||-||||||||||||||||||  1 [O] COG0602 Organic radical activating enzymes
|||||||||||||---|-||----------|---|-||----|||||-||||||||||||||||||  1 [R] COG0603 Predicted PP-loop superfamily ATPase
|-||||--|-||-||||-||||---|||||||||||||----|||||||||||||||||||-||||  1 [P] COG0607 Rhodanese-related sulfurtransferase
||||---||----------|-----------||-||--|||-------||||||--|||-||-|-|  1 [V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
|||||||||||||---|-||------||||------||----||||||||||||||--|----|--  1 [H] COG0611 Thiamine monophosphate kinase
||||----|--||---||||-|--------|------|----|||||-||||-|||----------  1 [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family)
|||||||||||||||||--------------|--|||----------------------------|  1 [MI] COG0615 Cytidylyltransferase
|||||||||-|-|---|||||||||-||||-----|||----||||||||||||||||||||||||  1 [OU] COG0616 Periplasmic serine proteases (ClpP class)
-|||--|||||-|---||||||--|||||-||||||||||||------|-----------------  1 [R] COG0618 Exopolyphosphatase-related proteins
|||||||||||||||-||-----|--||||-|-|||||----||||||||||||||--||--||--  1 [E] COG0620 Methionine synthase II (cobalamin-independent)
|||||||||||||---||||||-||-|||||---|-||----||||||||||||||||||||||||  1 [J] COG0621 2-methylthioadenine synthetase
||||--|||-------||||||--|||||-||||||||----||||||||||||||||||||||||  1 [R] COG0628 Predicted permease
|||-----|--|-----|||----------|-----------|||||---||--------|-----  1 [R] COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)
--||--|||--------|||-|--||----|----|||----|||||-||--|--||||||-||--  1 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases
---|--|||--||||-||--|-----|||--|||||||----|||||--|--------||||||||  1 [G] COG0647 Predicted sugar phosphatases of the HAD superfamily
--|||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7
||||-||||-|||----|||-|----|||-----||||----|||-|-||---------|||--||  1 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit
--|--|--|--|-||--|||-|--|-|||||||-||-|----|||||-||--|--|---||-||--  1 [I] COG0657 Esterase/lipase
|||---||||------|||||------||-------||----|||||-||--||||||-|||||--  1 [G] COG0662 Mannose-6-phosphate isomerase
--|||||||-|||||-|-||-|||-|||||||||-|||----|||||-||||||||||||||||--  1 [E] COG0665 Glycine/D-amino acid oxidases (deaminating)
|||||||||||||-||||||||--|||||-||||||||----||||||||--||||||||||||||  1 [M] COG0668 Small-conductance mechanosensitive channel
--------|---|||--||||---|---------|||-----||||---|-|-||---|--|--||  1 [P] COG0672 High-affinity Fe2+/Pb2+ permease
|||-----||---|-------|----||||-------|----|||||-||||---|---||-|---  1 [H] COG0684 Demethylmenaquinone methyltransferase
---|----|-|-|----|||||--||----||||||--|||||||||-||||-|||---|||||--  1 [E] COG0687 Spermidine/putrescine-binding periplasmic protein
||||----||---||-----||||---||||-----||----|||||-|||||||||||||||-||  1 [I] COG0688 Phosphatidylserine decarboxylase
|---|||||||||||||--|||----||||-----|||----|||||-||||||||---|||||||  1 [J] COG0689 RNase PH
-||||||||||||||-|-||||--||-||-|--|||||-||||||||-||-||--|--||||||--  1 [R] COG0693 Putative intracellular protease/amidase
---|----|----||---||--||----------||||----|||||||||||---||||||||||  1 [O] COG0694 Thioredoxin-like proteins and domains
|-||----|----|||-|||-|----|||||||||||-----|||||-||||||||---|||||||  1 [O] COG0695 Glutaredoxin and related proteins
|||-----||------||||-------||-|-||-|||----|||-------------|-------  1 [R] COG0701 Predicted permeases
-||||-|||||||||-||||-|--|-||||||||||||----|||||-|||||--|--||||||--  1 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
|-|-||--|--|-|||--||||--|||||-||||-||-----|||||-||||||||||||||||||  1 [L] COG0708 Exonuclease III
||||||-|||||-||-|-----||-------||||||-----|||-|------||-----------  1 [E] COG0710 3-dehydroquinate dehydratase
|||||||||||||---||||-|---||||||---||||----|||||-||--|--|---|||||--  1 [R] COG0714 MoxR-like ATPases
|||-----||---||---|||---|-----||||-||-----|||||||||||--||||-------  1 [C] COG0716 Flavodoxins
|||||||||||||---|-||--||--|||||------|----||||||-|||||||||||||||||  1 [F] COG0717 Deoxycytidine deaminase
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
||||||||||||----||||----------|---|-||----|||||-||||||||||||||||||  1 [H] COG0720 6-pyruvoyl-tetrahydropterin synthase
||||----||-||---||||||||||||||||||||||--||-------|---|||||||||||||  1 [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [P] COG0725 ABC-type molybdate transport system, periplasmic component
||||-|-||----------|-------||--|||||--|||||||-|-|||||---|||-||-|-|  1 [V] COG0732 Restriction endonuclease S subunits
-|||--|||-------|---|-|||-|------|||||----------|-||-||-|||-------  1 [R] COG0733 Na+-dependent transporters of the SNF family
--|-||--|-|||---||||||---||||||||-||||--|||||||-||||||||||||||||--  1 [P] COG0735 Fe2+/Zn2+ uptake regulation proteins
|--|----|----||-|||--|--|-|---|||-||||-|--|||||-|-||---|||-||-|---  1 [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases
|||||||||||||---|-||-|----|||-----||||----|||||-||||--||||||||||--  1 [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A
--|||||||-|||---||||||||--|||||||-||||----|||||-||||---||||||||---  1 [E] COG0747 ABC-type dipeptide transport system, periplasmic component
--|-----|-|-|---|-||-|----||||----|-||----|||||-||||||||||||||||||  1 [O] COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component
--|-----|-|-|----|||||||--|---||||||||----|||||-|||--|||||||||||||  1 [E] COG0765 ABC-type amino acid transport system, permease component
|-|---|||-|-|---||||||--|-||||--||--||------------||----||-||||---  1 [O] COG0785 Cytochrome c biogenesis protein
--|-----|-------|-||||----||||||||||||----|||||-||||||||||||||||||  1 [K] COG0789 Predicted transcriptional regulators
|||---|||||||---|---|-||------|---|||-----|||||-||||||||||||||||||  1 [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation
|-|---|-|----|---|||------|||-|----||--------------|--|----|------  1 [P] COG0798 Arsenite efflux pump ACR3 and related permeases
|-||--|||-|-|---|||||||||-||||||||||||-------||--|||-||---|||-|-||  1 [P] COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
----||--|----||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0807 GTP cyclohydrolase II
--|-----|---------||--||------------------|||||-|||||--|||||||||||  1 [U] COG0823 Periplasmic component of the Tol biopolymer transport system
--||--|||--------|||----||----|----|||----|||||-||--|--||||||-||--  1 [NT] COG0835 Chemotaxis signal transduction protein
--||--|||-------||||-|--------|-----------|||||-||--|---||-|||||-|  1 [M] COG0836 Mannose-1-phosphate guanylyltransferase
--||||--|-|||---|-||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A)
--||||--|--||---|-||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J)
----|---|----||||||--||||-|||-||||||||----||||||||||||||||||||||||  1 [L] COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases
--|||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit
||||||--|---------------------------------------------------------  1 [F] COG0856 Orotate phosphoribosyltransferase homologs
---|----|---------||-|-----||-------------||||||||||-||-|||-------  1 [R] COG0857 BioD-like N-terminal domain of phosphotransacetylase
||||--|||||||-----------------|----|||----|||-|---------||---|-|--  1 [K] COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain
|||-----||-----------|---|----|----|||----|||--------------||||---  1 [F] COG1001 Adenine deaminase
--||||--|-|||---|-||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H)
--||||--|-|||---|-||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N)
--||||-||-|||---|-||-|----|||-----||||----||||||||--||||||||||||||  1 [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG1010 Precorrin-3B methylase
|||||||||||--||---------------------------------------------------  1 [R] COG1019 Predicted nucleotidyltransferase
---|----|-|-|||||-|||---||||||---------------|--||||--------------  1 [I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
--|||||||-||||||||||||||--||||||||||||----||||||||||||||||||||||||  1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
--|-|||||-|-|---|-----------------|-||-----------|-----|----|-|---  1 [O] COG1030 Membrane-bound serine protease (ClpP class)
-|||--|||||-|----|------------------------------------------------  1 [C] COG1031 Uncharacterized Fe-S oxidoreductase
|||-----||--------||----------------------------------------|-----  1 [C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit
|||-----||--------------------------------------------------------  1 [C] COG1036 Archaeal flavoproteins
|||||||||||||||---------------------------------------------------  1 [L] COG1041 Predicted DNA modification methylase
|||||||||||||-------||--|-----------------|||||-|||||||||||-------  1 [O] COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
|||---|||||||---|-||-|----||||||-|-|||-------|--||-----|---|||||-|  1 [F] COG1051 ADP-ribose pyrophosphatase
----|||||-|||----||||-||---|||----||||----||||--||---|||--||--|---  1 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases
---||||||-||||---|||||-----||||-||||||----|||||-|----|||---|||||--  1 [R] COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA
-|--||--|--|----||--|---------------------------------------------  1 [L] COG1059 Thermostable 8-oxoguanine DNA glycosylase
--|||||||-||||||---|||--|-|||||-||||------|||||-|-----------------  1 [KL] COG1061 DNA or RNA helicases of superfamily II
--|||||||--||||--|-|-|-----||-||||||||--|-|||||-|||-||||---||-||--  1 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
||||||||||-------|------|-----|-----||----|||||-||||--------------  1 [O] COG1067 Predicted ATP-dependent protease
--------|----||---||-|----|---|---|-||-|--------||--|--|----------  1 [R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold
|---||--||------||-||-||||----|----|||----|||||-|||||--||||----|||  1 [D] COG1077 Actin-like ATPase involved in cell morphogenesis
|||||||||||||--|||--|----------||||||||-||------------------------  1 [R] COG1078 HD superfamily phosphohydrolases
---|--|||-|-|----|-|-|--||----||||-||-||||-------|-----|---||||---  1 [R] COG1079 Uncharacterized ABC-type transport system, permease component
||||||||||||||||--------------------------------------------------  1 [R] COG1084 Predicted GTPase
--|---|-|-|--||--|--------||--||----------|||||-|-||--------------  1 [C] COG1085 Galactose-1-phosphate uridylyltransferase
|-|--||||--||-|---||||----|||||||---||----|||||--|||||||---||-||--  1 [M] COG1088 dTDP-D-glucose 4,6-dehydratase
|-|-----|-------|-||-------||-|-----------|||-|-||--|---||-|-|||--  1 [M] COG1089 GDP-D-mannose dehydratase
|-||-||||--||---|-||||----|||||||---||----|---|--|--||||---||-||||  1 [M] COG1091 dTDP-4-dehydrorhamnose reductase
||||||||||||||||--------------------------------------------------  1 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)
||||||||||||||||--------------------------------------------------  1 [R] COG1094 Predicted RNA-binding protein (contains KH domains)
||||||||||||||||--------------------------------------------------  1 [K] COG1095 DNA-directed RNA polymerase, subunit E'
|-|-|||||||||||---------------------------------------------------  1 [J] COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain)
|-|-||||||||||||--------------------------------------------------  1 [J] COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)
||------||---------|----------------------------------------------  1 [R] COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold
|||||||||||||-----------||----------------------------------------  1 [F] COG1102 Cytidylate kinase
||||--||||--------------------------------------------------------  1 [L] COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain
|-||--|||-|-|---|||||||||-||-|||||||||----||||||||||-||---|||||-||  1 [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
|||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||  1 [G] COG1109 Phosphomannomutase
-|----|||||||---||------------------------------------------------  1 [L] COG1110 Reverse gyrase
||||||||||---||---------------------------------------------------  1 [L] COG1111 ERCC4-like helicases
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG1117 ABC-type phosphate transport system, ATPase component
|-||--|||-|||---|||||||||-|--|||||||||----||||||||||-||---|||||-||  1 [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component
--------|----------|||-----||-|||||||-----|||||--|------||-||||---  1 [E] COG1125 ABC-type proline/glycine betaine transport systems, ATPase components
--|-----|-|-|----|||||||--|---||||||||----|||||-|||--|||||||||||||  1 [E] COG1126 ABC-type polar amino acid transport system, ATPase component
--|-----|-|-|--------|--------------------|||||-|||||------|||||||  1 [O] COG1138 Cytochrome c biogenesis factor
|--|||--|-|||-------||---------|----||----|||------|-||||||-------  1 [C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain
|--|---||-|-|----|||-------||-||||||||----------------------------  1 [C] COG1141 Ferredoxin
|||---||||-------|||----------------------|||||-------------------  1 [C] COG1142 Fe-S-cluster-containing hydrogenase components 2
|||||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)
|||-----||-|----|-------------------------------------------------  1 [C] COG1150 Heterodisulfide reductase, subunit C
|||----|||-------|--|---------|-----------|||||-------------------  1 [C] COG1151 6Fe-6S prismane cluster-containing protein
|||-----||--------------------------------------------------------  1 [C] COG1153 Formylmethanofuran dehydrogenase subunit D
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B
||||||||||||||||--------------------------------------------------  1 [R] COG1163 Predicted GTPase
--|||||||-|||---||||||||-||||||||||||||||||||||-||||---||-|||||---  1 [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
---|----|-|-|----|-|||--||----||||||--|||||||||-||||-|||---|||||--  1 [E] COG1176 ABC-type spermidine/putrescine transport system, permease component I
---|----|-|-|----|-|||--||----||||||--|||||||||-||||-|||--||||||--  1 [E] COG1177 ABC-type spermidine/putrescine transport system, permease component II
||||----||---||-----|-||-|-||||-----||-----------|--|||||||||||-||  1 [I] COG1183 Phosphatidylserine synthase
-||||||||-|-|||--|------------------------------------------------  1 [J] COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
--|-----|-------|||||----|||||||||-|||||----------------||||||||||  1 [J] COG1189 Predicted rRNA methylase
-||||||||----|||||||||--||||||||||||||||||-------|--|||----|||||--  1 [D] COG1196 Chromosome segregation ATPases
|||||||||||||||||-------------------------|----------------||-----  1 [R] COG1204 Superfamily II helicase
|||---||||||-||----|-|----|||-------||-----||---------------|-----  1 [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
|||||||||||||||||-||-|----|||||-----||-------||--|--||||--||||||--  1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)
|-|||||||--||----|||-|----|||||||---||----|||||--|--||||---||-||--  1 [M] COG1209 dTDP-glucose pyrophosphorylase
||||--||||-|||||--------------------------------------------------  1 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit
|||-----||--------------------------------------------------------  1 [R] COG1223 Predicted ATPase (AAA+ superfamily)
------||||||||||--------------------------------------------------  1 [K] COG1224 DNA helicase TIP49, TBP-interacting protein
-|------|----|||-|--||--------|||||||-----------|-----------------  1 [C] COG1227 Inorganic pyrophosphatase/exopolyphosphatase
|--||||-|--|-|---|--||-----||-|-|-|-||-------||-||-----|---|||||--  1 [Q] COG1228 Imidazolonepropionase and related amidohydrolases
|||-----||--------------------------------------------------------  1 [C] COG1229 Formylmethanofuran dehydrogenase subunit A
--||--|-|-|--||-|----|||--||||----||||-------|---------|-------|--  1 [H] COG1232 Protoporphyrinogen oxidase
||||||||||----|-|-|||-||||----||||||||----||||---|-----|---|||||||  1 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
||||||--||--------||-|----|||--------------------|-----|----------  1 [H] COG1239 Mg-chelatase subunit ChlI
||||||||||||||||--------------------------------------------------  1 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family
||||||||||||-|||-|--|---------|-----------------------------------  1 [KB] COG1243 Histone acetyltransferase
||||||||||--------------------|-----------------------------------  1 [R] COG1244 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
||||||--|||||||-||||||||--||||-|||||||-|||||||||||||||||---|||||||  1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
-||-|||||-|||----|-|-|---|--|-||||||||----|||||-||-|---|----|-|---  1 [C] COG1254 Acylphosphatases
||-|--|||---------------------------------------------------------  1 [S] COG1255 Uncharacterized protein conserved in archaea
||||||||||||||||---------|-----|||||------------|-----------------  1 [I] COG1257 Hydroxymethylglutaryl-CoA reductase
|||||||||||||--|--------------------------------------------------  1 [J] COG1258 Predicted pseudouridylate synthase
--||----|-|||---||||--||--||||------------------------------------  1 [S] COG1259 Uncharacterized conserved protein
|-|---|||-||||--||--------||||------------------------------|-----  1 [I] COG1260 Myo-inositol-1-phosphate synthase
|-||--|||--------||||||-|-|---||||||||---------------------||||-||  1 [R] COG1268 Uncharacterized conserved protein
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I
|||||||||||||-----||||-----||-|----|-|--------|-||-----|---||||---  1 [H] COG1270 Cobalamin biosynthesis protein CobD/CbiB
--------|------------------||-------||-----------|---------||-|---  1 [S] COG1273 Uncharacterized conserved protein
-|--|-|||----||-----------|||--||||-------|||-|-|-||-|------------  1 [P] COG1275 Tellurite resistance protein and related permeases
--|||||||--||----|||-|--||----|---|||||||--------|-----|----||----  1 [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
|-|-||--|||||----||--|----|---------||----|||||-|||||--|--||||||--  1 [E] COG1280 Putative threonine efflux protein
||||||||||||||||-|||||---|----||||||||------------------|||-------  1 [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP
--|-----|-----------||----|----|-|||||----|||||-||||-|||||-||||---  1 [E] COG1296 Predicted branched-chain amino acid permease (azaleucine resistance)
|||---||||--|-----||-------||-|---|-||-----------|------------||--  1 [S] COG1300 Uncharacterized membrane protein
||||||||||-||-----------------------------------------------------  1 [S] COG1303 Uncharacterized protein conserved in archaea
|||||||||||-||||--------------------------------------------------  1 [K] COG1308 Transcription factor homologous to NACalpha-BTF3
|-||---||--|----||||||----|||||||||||||---|||||-||||||||--||||||--  1 [K] COG1309 Transcriptional regulator
|-|||||||||||||||-||-|-----||--------------||||--|-----|----------  1 [R] COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily
||||||||||---|||--------------------------------------------------  1 [L] COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
|||---|||||-|---||------------|-----------------------------------  1 [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins
-|----|||||-|---||------------------------------------------------  1 [K] COG1318 Predicted transcriptional regulators
|-|-|||||||-|--|||-|-|-|------------------|||||-----|--|--------||  1 [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations
||||--|||||||-----------------------------------------------------  1 [J] COG1325 Predicted exosome subunit
||||--||||--------------------------------------------------------  1 [R] COG1326 Uncharacterized archaeal Zn-finger protein
|-||||--|-|||---|--|-|||---||-|-----|------------------------||---  1 [O] COG1331 Highly conserved protein containing a thioredoxin domain
|-------||-|----||-------------------|----------------------------  1 [L] COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||||||||||||-----------------------------------------------------  1 [KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon
|-|||||||||||-----------------------------------------------------  1 [S] COG1340 Uncharacterized archaeal coiled-coil protein
-|----|||||||||---------------------------------------------------  1 [R] COG1341 Predicted GTPase or GTP-binding protein
|||---|||---------------------|-----------------|-----------------  1 [R] COG1342 Predicted DNA-binding proteins
|-|-|||||-|||---||------------------------------------------------  1 [R] COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)
--||--|||--------|-|----||----|----|||----|||||-||-----|--|||-||--  1 [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins
|||--||-||||----||---------||--------|----------------------------  1 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs)
-||||||||-------||||||--|-||||||||||||||||-------|--||||---|||||--  1 [S] COG1354 Uncharacterized conserved protein
|||-|||||||||||-||--------------------------------------------|---  1 [R] COG1355 Predicted dioxygenase
||||||||||||||||-|--|---------||||||||----------------------------  1 [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a)
||||--|||||-|----|-|||--------||||||||||--|||-|--|----------|-----  1 [G] COG1363 Cellulase M and related proteins
|||-----||---||-||||-|----||||||--||||-----------|---|||---|||||--  1 [E] COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase)
--------|-------||-------------------|----------------------------  1 [L] COG1367 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
||||--||||-||||---------------------------------------------------  1 [J] COG1369 RNase P/RNase MRP subunit POP5
|||||||||||||-----------------------------------------------------  1 [O] COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit
|||||||||||||---||---------||-------------------------------------  1 [S] COG1371 Uncharacterized conserved protein
-|----||||--||||--------------------------------------------------  1 [J] COG1374 Protein involved in ribosomal biogenesis, contains PUA domain
|||||||||||||||---------------------------------------------------  1 [O] COG1382 Prefoldin, chaperonin cofactor
||||||||||||||||--------------------------------------------------  1 [J] COG1383 Ribosomal protein S17E
||||||||||--|-----------||-----------------------------------|||||  1 [J] COG1384 Lysyl-tRNA synthetase (class I)
--|-|||||--------|||||--|-||||||||||||||||-------|--||||---|||||--  1 [K] COG1386 Predicted transcriptional regulator containing the HTH domain
||||--|||||||-----------------------------------------------------  1 [L] COG1389 DNA topoisomerase VI, subunit B
|||||||||||-||||----||||||----------------------------------------  1 [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D
|||||||||||||-----------------------------------------------------  1 [K] COG1395 Predicted transcriptional regulator
-||-----|-------|--|-|--------|--|--------|||-|---------------|---  1 [O] COG1397 ADP-ribosylglycohydrolase
||||||||||||||||--------------------------------------------------  1 [U] COG1400 Signal recognition particle 19 kDa protein
||||||||||||||||--------------------------------------------------  1 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
|-|---|||||-|||-|-||--||--||||||--|||-----|||||-||||---|---|||||--  1 [R] COG1409 Predicted phosphohydrolases
|||-----||--------------------------------------------------------  1 [R] COG1411 Uncharacterized protein related to proFAR isomerase (HisA)
||||||||||||||||--------------------------------------------------  1 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
|---|||||||||-----------------------------------------------|-|---  1 [S] COG1415 Uncharacterized conserved protein
|--|||--|-------|----|---------------------------------|------|---  1 [S] COG1416 Uncharacterized conserved protein
||||||||||--------------------------------------------------------  1 [S] COG1422 Predicted membrane protein
|||---||||--|---|-------------------------------------------------  1 [L] COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III
----||--|-|-|---|----|||-------------|------------------|||-------  1 [R] COG1427 Predicted periplasmic solute-binding protein
-|------||------|-------------------------------------------------  1 [J] COG1431 Uncharacterized protein containing piwi/argonaute domain
||||--||||------|-||-|--|-|---------------------||----|-||||||||--  1 [S] COG1432 Uncharacterized conserved protein
||||||||||||||||----||--|--------|--------------------------------  1 [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F
||||--|||||||------------|----|--------------|---------|----------  1 [F] COG1437 Adenylate cyclase, class 2 (thermophilic)
||||||||||||||||--------------------------------------------------  1 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
---|--||||||||||--------------------------|||||-|-||--------------  1 [R] COG1444 Predicted P-loop ATPase fused to an acetyltransferase
||||--|||-------|---||----|---|-------||--|||||-||--||||||||||||-|  1 [R] COG1451 Predicted metal-dependent hydrolase
|||-----||--------------------------------------------------------  1 [C] COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)
|||---||||--|---|-------------------------------------------------  1 [R] COG1458 Predicted DNA-binding protein containing PIN domain
|||||||||||||-----------------------------------------------------  1 [S] COG1460 DNA-directed RNA polymerase, subunit F
||||----||------|-------------------------------------------------  1 [E] COG1465 Predicted alternative 3-dehydroquinate synthase
||||||||||--|----|----------------|-||-----------|--||||----------  1 [S] COG1469 Uncharacterized conserved protein
--|---|||----------------------------|----------------------------  1 [S] COG1470 Predicted membrane protein
||||||||||||||||--------------------------------------------------  1 [J] COG1471 Ribosomal protein S4E
||-|--|||-|||---|--|-|||||||||||||||||----|||||-||--||||||||||||||  1 [K] COG1475 Predicted transcriptional regulators
||||----||------------||---|||--|---------------------------------  1 [S] COG1478 Uncharacterized conserved protein
--------|----||--|---|---|||||||||||||-|--|||||-|--|--------------  1 [G] COG1482 Phosphomannose isomerase
--|||||||||||||-||||||--|||||-||||||||||||||||||||-|||||--|||||---  1 [H] COG1488 Nicotinic acid phosphoribosyltransferase
|---||--|-|||---||||----------|------|----|||||-||||-------|||-|--  1 [R] COG1489 DNA-binding protein, stimulates sugar fermentation
|||||||||||||-----------------------------------------------------  1 [J] COG1491 Predicted RNA-binding protein
||||||--||-|------||||-----||-|----|-|--------|-||-----|---|||||--  1 [H] COG1492 Cobyric acid synthase
||||||--||--------------------------------------------------------  1 [K] COG1497 Predicted transcriptional regulator
||||||||||||||||--------------------------------------------------  1 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog
||||||||||||||||--------------------------------------------------  1 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay
||||||||||||||||--------------------------------------------------  1 [J] COG1500 Predicted exosome subunit
----||--|-|--|||-||||-||--|---||||||||||--||||||||||||||||-|||||||  1 [I] COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes
|||||||||||||||||-------------------------------------------------  1 [J] COG1503 Peptide chain release factor 1 (eRF1)
|-|---||||--------------------------------------------------------  1 [S] COG1504 Uncharacterized conserved protein
|||-|||||||||---||-|-|----|---|---|-||----|||||--|-----|---|||||--  1 [J] COG1514 2'-5' RNA ligase
---||||||||||-|-||-|-|--------|-----|-----|||||-----|-------------  1 [L] COG1515 Deoxyinosine 3'endonuclease (endonuclease V)
||||--|||--------|---|---|-|||------|-----|||||-||--|--|-------|||  1 [S] COG1520 FOG: WD40-like repeat
----|||||--|-|||-|-|------|---|----|-|-----------|--|-----|-|-||--  1 [R] COG1524 Uncharacterized proteins of the AP superfamily
|||-||--|-||--------------|||-----||||----|||||-||||---|--||||||--  1 [C] COG1526 Uncharacterized protein required for formate dehydrogenase activity
|||||||||||--|||----||----------||--------------------------------  1 [C] COG1527 Archaeal/vacuolar-type H+-ATPase subunit C
|-|-----|------|-|--------|||-|---|--||---|||||-|-||----|||-------  1 [P] COG1528 Ferritin-like protein
||-----||||||-----------------------------------------------------  1 [S] COG1531 Uncharacterized protein conserved in archaea
||------||--------------------------------------------------------  1 [R] COG1532 Predicted RNA-binding protein
||||--||||-||-------|---------||||||||----|||||-||||||||----------  1 [J] COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
||||||||||||||||--------------------------------------------------  1 [R] COG1537 Predicted RNA-binding proteins
|||-----||--------------------------------------------------------  1 [KG] COG1548 Predicted transcriptional regulator/sugar kinase
||||||||||-|------------------------------------------------------  1 [J] COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain
||||||||||||||||--------------------------------------------------  1 [J] COG1552 Ribosomal protein L40E
---|----|-----------||---------|----||----|||------|-||||||-------  1 [S] COG1556 Uncharacterized conserved protein
-|----|||-------|-------------------------------------------------  1 [R] COG1568 Predicted methyltransferases
-|----|||---------||--------------------------------|-------------  1 [R] COG1569 Predicted nucleic acid-binding protein, contains PIN domain
|||||||||||||-----------------------------------------------------  1 [R] COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
--|||||||-|||---||||||--|--|||||||--------------|-|--|||||||||||||  1 [L] COG1573 Uracil-DNA glycosylase
||||--||||||||||---------|-----|||||------------------------------  1 [I] COG1577 Mevalonate kinase
|||---|||||-----||------------------------------------------------  1 [S] COG1578 Uncharacterized conserved protein
|||--||||-------||------------------------------------------------  1 [L] COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
-|--|||||-|||---||------------|-----||----||||||-|--|--|----------  1 [E] COG1586 S-adenosylmethionine decarboxylase
||||||--||||-||-|-||||||--|||||---||||----|||||-||-||||||||||||---  1 [H] COG1587 Uroporphyrinogen-III synthase
||||||||||--|-----------------------------------------------------  1 [J] COG1588 RNase P/RNase MRP subunit p29
-|----|||||||||---------------------------------------------------  1 [S] COG1590 Uncharacterized conserved protein
||-|--|||||||-----------------------------------------------------  1 [L] COG1591 Holliday junction resolvase - archaeal type
|||||||||-||||||--------------------------------------------------  1 [K] COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS
|-|||---|--------|||-------------|--------||||--------|--|--|-||-|  1 [S] COG1598 Uncharacterized conserved protein
|-|-----|---------||-|--------|-|-||||----|||||-||-----|---|||||--  1 [C] COG1600 Uncharacterized Fe-S protein
||||||||||||||||--------------------------------------------------  1 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain
||||--||||-||||---------------------------------------------------  1 [J] COG1603 RNase P/RNase MRP subunit p30
--------||-|----||-------------------|----------------------------  1 [L] COG1604 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
||||||--|||||||-||--||----||||||||||||----||||||||||||||||||||||--  1 [E] COG1605 Chorismate mutase
|||||||||||||-----------------------------------------------------  1 [R] COG1608 Predicted archaeal kinase
--|-||||||||-|--||-|||||--||||-|--|-||----|||||-||-|||||--||||||--  1 [R] COG1611 Predicted Rossmann fold nucleotide-binding protein
|||-----||--------------------------------------------------------  1 [C] COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit
--------|---------||------|||||-----------------------------------  1 [S] COG1615 Uncharacterized conserved protein
|||---||||--------------------------------------------------------  1 [S] COG1617 Uncharacterized conserved protein
|||-|||||||||---||------------------------------------------------  1 [F] COG1618 Predicted nucleotide kinase
---|----||-|---------|---|--------|-||----|||-|-||||-||||||--|----  1 [C] COG1620 L-lactate permease
-|||--||||------|-||-|||||----||||||||-|||------------------------  1 [S] COG1624 Uncharacterized conserved protein
|||||||||||||--------|--------------------------------------------  1 [S] COG1628 Uncharacterized conserved protein
||--|||||--||-----------------------------------------------------  1 [S] COG1630 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1631 Ribosomal protein L44E
||||||||||||||||--------------------------------------------------  1 [J] COG1632 Ribosomal protein L15E
|||||||||||||-----------------------------------------------------  1 [R] COG1634 Uncharacterized Rossmann fold enzyme
||||--|||||||||--|------------------------------------------------  1 [H] COG1635 Flavoprotein involved in thiazole biosynthesis
|||-----||-------|||------|---|-----------------------------------  1 [S] COG1641 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
-|||--|||||||-----------------------------------------------------  1 [R] COG1645 Uncharacterized Zn-finger containing protein
|||||||||||||---------------------||||----------------------------  1 [R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold
||||||--|||-|||-|---|------||-|---||||----||||||||--|||----|||||--  1 [H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)
-||||||||||||-----------------------------------------------------  1 [S] COG1650 Uncharacterized protein conserved in archaea
---|----|-|-----|-||-|||--||||----|||-----|||||-||||||||||||||||||  1 [O] COG1651 Protein-disulfide isomerase
--||---||------------|--------||||||||----|||||-|||||-------------  1 [K] COG1654 Biotin operon repressor
----|||||||||---||------|--||--------------------------|----------  1 [S] COG1656 Uncharacterized conserved protein
|||-|||||-------|---|----|----|||||||||-||------------------------  1 [L] COG1658 Small primase-like proteins (Toprim domain)
|-||||||||--|---------------------|--------||-|-|----------||-|---  1 [R] COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif
|||-----||-|------------------------------------------------------  1 [S] COG1665 Uncharacterized protein conserved in archaea
||------||--------------------------------------------------------  1 [S] COG1667 Uncharacterized protein conserved in archaea
-||-----|--------||--|-------------------------------|-----|---|--  1 [R] COG1669 Predicted nucleotidyltransferases
||----|||-||------------------------------------------------------  1 [S] COG1673 Uncharacterized protein conserved in archaea
||||--||||||||||--------------------------------------------------  1 [K] COG1675 Transcription initiation factor IIE, alpha subunit
||||||||||||||||--------------------------------------------------  1 [J] COG1676 tRNA splicing endonuclease
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1679 Uncharacterized conserved protein
||||||-||||||-----------------------------------------------------  1 [EH] COG1685 Archaeal shikimate kinase
|||---|||-|||---||------------------------------------------------  1 [L] COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|-----|||---------------------------------------------------------  1 [S] COG1689 Uncharacterized protein conserved in archaea
|||||||||||||--|||-|-|----|||-|------|----|||-|--|-----|----------  1 [S] COG1690 Uncharacterized conserved protein
|||-----||-------|||------|---|-----------------------------------  1 [R] COG1691 NCAIR mutase (PurE)-related proteins
|||-----||--------------------------------------------------------  1 [S] COG1693 Uncharacterized protein conserved in archaea
||||--||||||||||--------------------------------------------------  1 [L] COG1697 DNA topoisomerase VI, subunit A
|||-||||||-||-----------------------------------------------------  1 [S] COG1698 Uncharacterized protein conserved in archaea
||||--|||||||-----------------------------------------------------  1 [S] COG1701 Uncharacterized protein conserved in archaea
---||||||--||--------|----||||-------|----|||----------|-------|--  1 [E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family
||------||--------------------------------------------------------  1 [R] COG1707 ACT domain-containing protein
-||||||||||||-----------------------------------------------------  1 [K] COG1709 Predicted transcriptional regulator
|-|||||||---------------------------------------------------------  1 [S] COG1711 Uncharacterized protein conserved in archaea
|||-----|||------|-------------------------------|-----|----------  1 [R] COG1712 Predicted dinucleotide-utilizing enzyme
||||||||||||||||--------------------------------------------------  1 [J] COG1717 Ribosomal protein L32E
||||||||||||||||-----|-----------------------|---|----------------  1 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control
--|||||||-|-|---||||-|---|-|||-----|||----------||-----|---|||||--  1 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
||||||||||||||||--------------------------------------------------  1 [J] COG1727 Ribosomal protein L18E
|||||||||||||||-|-------------------------------------------------  1 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding
|||-----|||||-----------------------------------------------------  1 [H] COG1731 Archaeal riboflavin synthase
---|----|----------|||-----||-|||||||-----|||-|--|-----|||-||||---  1 [M] COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
||||||||||||||||--------------------------------------------------  1 [J] COG1736 Diphthamide synthase subunit DPH2
--||----|-|-|----|--||||-||-------|-|-----|||||-||||-||----||||---  1 [S] COG1738 Uncharacterized conserved protein
--|-----|-------|--|----------|-----------|||-|---------|||-------  1 [C] COG1740 Ni,Fe-hydrogenase I small subunit
------||||--|----|------------------------------------------|-----  1 [L] COG1743 Adenine-specific DNA methylase containing a Zn-ribbon
---|--|||-|-|----|-|-|--||----||||-|||||||-------|-----|---||||---  1 [R] COG1744 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein
|||||||||||||-----------------------------------------------------  1 [J] COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme)
----|||-|-|-|||---||-|-----------|---|----------|--|----|||||||---  1 [E] COG1748 Saccharopine dehydrogenase and related proteins
-||---|||-|||-----------------------------------------------------  1 [R] COG1750 Archaeal serine proteases
|||-----|--------|------------------------------------------------  1 [S] COG1751 Uncharacterized conserved protein
-|--||||||||||||--------------------------------------------------  1 [S] COG1756 Uncharacterized conserved protein
||||||||||||||||||||-|--||||||||||||||----|||||-||||||||||||||||||  1 [K] COG1758 DNA-directed RNA polymerase, subunit K/omega
||||||||||||||||--------------------------------------------------  1 [K] COG1761 DNA-directed RNA polymerase, subunit L
|||||-|||||||---|-----------------||||----|||||-|-||---|--|||||---  1 [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein
|||---||||-||-------|-----------|---------|||-|-|||---------------  1 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase
--------|-------||------------------------------------------------  1 [L] COG1769 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
-||---||||--------------------------------------------------------  1 [S] COG1772 Uncharacterized protein conserved in archaea
--||--|||--------|------|-----|----|||----------|-------|||-------  1 [NT] COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
|-|||||||---------------------------------------------------------  1 [K] COG1777 Predicted transcriptional regulators
|||-|||||||||||---------------------------------------------------  1 [R] COG1779 C4-type Zn-finger protein
|||||||||||||----|------------|-----------|||||||----||-----------  1 [F] COG1781 Aspartate carbamoyltransferase, regulatory subunit
|||||||||||||-----------------------------------------------------  1 [R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain
||||--||||--------------------------------------------------------  1 [S] COG1784 Predicted membrane protein
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1786 Uncharacterized conserved protein
--------|--|--------||----|||-|-|---||----|------||----|||-|||||-|  1 [I] COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit
||------||--------------------------------------------------------  1 [S] COG1790 Uncharacterized protein conserved in archaea
------|||----------------------|----|-----|||||----|---|--|||-||--  1 [M] COG1794 Aspartate racemase
|||-----||-----------------------------------|--------------------  1 [S] COG1795 Uncharacterized conserved protein
||||||--||||------||||-----||-|----|-|--------|--|-----|---||||---  1 [H] COG1797 Cobyrinic acid a,c-diamide synthase
||||||||||||||||--------------------------------------------------  1 [J] COG1798 Diphthamide biosynthesis methyltransferase
-|----|-|---------------------------------------------------------  1 [R] COG1800 Predicted transglutaminase-like proteases
--|-|||||-|||---||-|-|------------||||----|||||-||-|---|---||-||--  1 [S] COG1801 Uncharacterized conserved protein
------|||-------|-|||---------|-----|-----|||||--|--||||---|||||--  1 [M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
-|||----|---|-----||-------------|--------------------------------  1 [S] COG1808 Predicted membrane protein
--------|--------|--||--------|----|||----|||-|-------------------  1 [R] COG1811 Uncharacterized membrane protein, possible Na+ channel or pump
|||||||||||||---|---------------|---------------------------------  1 [E] COG1812 Archaeal S-adenosylmethionine synthetase
||||||||||||||||--------------------------------------------------  1 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1
||----||||||||----------------------------------------------------  1 [R] COG1818 Predicted RNA-binding protein, contains THUMP domain
|||-----||--------------------------------------------------------  1 [R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)
|-||--||||--|-----------------------------------------------------  1 [P] COG1824 Permease, similar to cation transporters
||||||||||||----||||-|----||||-|--||||--------------------|-||||--  1 [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component
||||--|||||||-----------------------------------------------------  1 [R] COG1829 Predicted archaeal kinase (sugar kinase superfamily)
|||||||||||-|-----------------------------------------------------  1 [R] COG1831 Predicted metal-dependent hydrolase (urease superfamily)
||||-|||||||-----|------------------------------------------------  1 [S] COG1833 Uncharacterized conserved protein
|||||||||-|-------||-----------------|----------------------------  1 [S] COG1836 Predicted membrane protein
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain
|---|||||-|||----|---------||--------------------------|----------  1 [S] COG1839 Uncharacterized conserved protein
||||||||||||||||||--||--||||||||||||||----||||||||||||||----||||||  1 [J] COG1841 Ribosomal protein L30/L7E
|||||||||||||----|-|||----||||||||||||----|||||-||--||||---|||||--  1 [K] COG1846 Transcriptional regulators
|||||||||||||-----------------------------------------------------  1 [S] COG1849 Uncharacterized protein conserved in archaea
|||----||-----------|---------------------------------------------  1 [S] COG1852 Uncharacterized conserved protein
|||||||||||||-----------------------------------------------------  1 [R] COG1855 ATPase (PilT family)
|||||||-|-|-------------------------------------------------------  1 [S] COG1860 Uncharacterized protein conserved in archaea
-||||||||||||-----------------------||----------------------------  1 [S] COG1865 Uncharacterized conserved protein
|||||||||||||||||-------------------------------------------------  1 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase
--||--|||--------|-------|----|-----||----------||-----|---||--|--  1 [NT] COG1871 Chemotaxis protein; stimulates methylation of MCP proteins
|||----|||--|------|--||----|-------------|||||-|--|-------|--||||  1 [S] COG1872 Uncharacterized conserved protein
||||||-||-||-----|||------|||-----|--|-----------|||---|---||-|---  1 [R] COG1878 Predicted metal-dependent hydrolase
|-|||||||--|-|--|-----||--|||||---|-|-|---|||-|-|--|||||||-||-|--|  1 [R] COG1881 Phospholipid-binding protein
|-------|-----------|---------||||||------|||||-|-||---|----------  1 [C] COG1882 Pyruvate-formate lyase
------|||--------|--|---|-------|-------------|-|--|--------------  1 [C] COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit
-|||--||||--------------------------------------------------------  1 [S] COG1885 Uncharacterized protein conserved in archaea
||--|||||||||-----------------------------------------------------  1 [S] COG1888 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1889 Fibrillarin-like rRNA methylase
||||||||||||||||--------------------------------------------------  1 [J] COG1890 Ribosomal protein S3AE
|||-----||--------------------------------------------------------  1 [S] COG1891 Uncharacterized protein conserved in archaea
|-||--||||||------------------------------------------------------  1 [S] COG1892 Uncharacterized protein conserved in archaea
---|--|||-|-|||-|--|------|||-|||-||||----|||||-||-----|------||--  1 [H] COG1893 Ketopantoate reductase
-||---|-|--------|------------------------------------------------  1 [S] COG1895 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
---|--|||||||||------|------------||------|||||-||-|----||||||||--  1 [R] COG1896 Predicted hydrolases of HD superfamily
|-|--||||--||-----||||----|||||||||-||----|---|--|-|||||--||||||--  1 [M] COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes
|||-----||--------||----------------------------------------------  1 [S] COG1900 Uncharacterized conserved protein
-|||--|||||-|-----------------------------------|-----------------  1 [S] COG1901 Uncharacterized conserved protein
|||-||--||||------|||---------|----|----------|--|-----|---|-|----  1 [H] COG1903 Cobalamin biosynthesis protein CbiD
------|||-|------|------------------------------------------------  1 [S] COG1906 Uncharacterized conserved protein
|||---||||-||-----------------------------------------------------  1 [R] COG1907 Predicted archaeal sugar kinases
|||-|||||||||-----------------------------------------------------  1 [S] COG1909 Uncharacterized protein conserved in archaea
-|||||--|-|-------------------|-----|------------------|----------  1 [P] COG1910 Periplasmic molybdate-binding protein/domain
|||---||||||||||--------------------------------------------------  1 [J] COG1911 Ribosomal protein L30E
-|||--|||||||---||-|-------------|||-------||-----------||--------  1 [S] COG1912 Uncharacterized conserved protein
-|-|--|||||||---|-------------------------------------------------  1 [R] COG1913 Predicted Zn-dependent proteases
||------||--------||----------------------------------------------  1 [S] COG1915 Uncharacterized conserved protein
||||--||||--------------||--------------------------|-------------  1 [S] COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein)
|||----|||-------||--|--------||--||------|||||-||--|--|-||----|--  1 [P] COG1918 Fe2+ transport system protein A
||||----||-----------------|||------------------------------------  1 [S] COG1920 Uncharacterized conserved protein
|||-----||------||--|---------||---|------|||---------------------  1 [I] COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)
|||-----||--------------------------------------------------------  1 [C] COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase
||||----|----------|---------------|----------|-------------------  1 [P] COG1930 ABC-type cobalt transport system, periplasmic component
||||--|||||||-----------------------------------------------------  1 [S] COG1931 Uncharacterized protein conserved in archaea
||||||||||--------------------------------------------------------  1 [L] COG1933 Archaeal DNA polymerase II, large subunit
-||---||||--------------------------------------------------------  1 [S] COG1935 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)
|||||||||||||-----------------------------------------------------  1 [R] COG1938 Archaeal enzymes of ATP-grasp superfamily
---|||--|-|-|---||||||---|||||||||||||-|--|||||-|-||-------|||||--  1 [KG] COG1940 Transcriptional regulator/sugar kinase
|||---||||--------||----------------------------------------------  1 [C] COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit
|-------|----------|------|----|||||||----||||------|||||||||-||--  1 [R] COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain
-||||||||--||-----------------------------------------------------  1 [NU] COG1955 Archaeal flagella assembly protein J
|||-----||--------------------------------------------------------  1 [H] COG1962 Tetrahydromethanopterin S-methyltransferase, subunit H
|||-|||||||||--------------||-------------------------------------  1 [R] COG1964 Predicted Fe-S oxidoreductases
||||--|||---------------------------------------------------------  1 [S] COG1967 Predicted membrane protein
|||-----||-|------------------------------------------------------  1 [O] COG1973 Hydrogenase maturation factor
||||||||||||||||--------------------------------------------------  1 [J] COG1976 Translation initiation factor 6 (eIF-6)
||--|||||||||---|-------------------------------------------------  1 [G] COG1980 Archaeal fructose 1,6-bisphosphatase
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis
||--||--|||||------------------------|----|||||-|-----------------  1 [S] COG1986 Uncharacterized conserved protein
||||--||||------||||-|----|||-||||||||----|||||-||||||||--|---||--  1 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
||||||||||||||||----------|---------------------------------------  1 [S] COG1990 Uncharacterized conserved protein
||||||-||||||---||||-|-----||-|----|||----------|----|||||--|-||--  1 [R] COG1994 Zn-dependent proteases
|||||||||||||||---------------|-----------------------------------  1 [K] COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger)
||||||||||||||||--------------------------------------------------  1 [J] COG1997 Ribosomal protein L37AE/L43A
|||||||||||||||---------------------------------------------------  1 [J] COG1998 Ribosomal protein S27AE
||||||||||||||||--------------------------------------------------  1 [J] COG2004 Ribosomal protein S24E
|-|-----||||------------------------------|||||--|||---|--|||-||--  1 [R] COG2005 N-terminal domain of molybdenum-binding protein
||||||||||||||||--------------------------------------------------  1 [J] COG2007 Ribosomal protein S8E
---|||--|-|-|||------|||---|||----|-||----|||||-||--||||||||||||||  1 [C] COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit
--|-----|---------||-|----||||------||----------||---|||||||||||--  1 [C] COG2010 Cytochrome c, mono- and diheme variants
||||||||||||||||--------------------------------------------------  1 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5
|-||||-|||-||----||--|--------|||----------------|------------||--  1 [S] COG2013 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2016 Predicted RNA-binding protein (contains PUA domain)
||------||------|----|-----||------------------------||-----------  1 [R] COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid
--|---|||---||||--||-------||-|-----------------|-||---|----|||---  1 [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase
||||||||||-|||||--------------------------------------------------  1 [J] COG2023 RNase P subunit RPR2
|||-----||--------------------------------------------------------  1 [J] COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type)
---|||--|-|||||--|--||----|||||-----||----|||-|--|--||||---|||||--  1 [C] COG2025 Electron transfer flavoprotein, alpha subunit
-|----|||---------------------------------------------------------  1 [S] COG2028 Uncharacterized conserved protein
--------|---|-------|-----|-----|----|----|------||-----||--------  1 [I] COG2031 Short chain fatty acids transporter
|||||||||||||-----||||----|||||------|----|||-|-||-----|---|||||--  1 [H] COG2038 NaMN:DMB phosphoribosyltransferase
--||||--|-|||---|--|-|----|||-------|-----|||||--|-|---|--||||||--  1 [R] COG2041 Sulfite oxidase and related enzymes
-------||-|||||-|-||-|--------------||--------------------|-------  1 [P] COG2046 ATP sulfurylase (sulfate adenylyltransferase)
||||||||||--------------------------------------------------------  1 [R] COG2047 Uncharacterized protein (ATP-grasp superfamily)
||||||||||||||||--------------------------------------------------  1 [J] COG2051 Ribosomal protein S27E
||||||||||||||||--------------------------------------------------  1 [J] COG2053 Ribosomal protein S28E/S33
|||-----||--------------------------------------------------------  1 [R] COG2054 Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases
||||||||||||||||--------------------------------------------------  1 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2
|||-----||--------------------------------------------------------  1 [E] COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase
--------|-|||---|-||------||||------------|||||-|||||--|--||||||--  1 [T] COG2062 Phosphohistidine phosphatase SixA
|||-----||--------------------------------------------------------  1 [C] COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein)
--------|----|--||-|||----|||-||||||||-----------|--||||||||||-|--  1 [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase
||-|||--||||------|||---------|----|----------|--|-----|---||||---  1 [H] COG2073 Cobalamin biosynthesis protein CbiG
||||||||||||||||--------------------------------------------------  1 [J] COG2075 Ribosomal protein L24E
|||||||||||||||-||------------|-----------------------------------  1 [S] COG2078 Uncharacterized conserved protein
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2082 Precorrin isomerase
||----||||--------------------------------------------------------  1 [S] COG2083 Uncharacterized protein conserved in archaea
---|||--|-|||||--|--||----|||||-----||----|||-|--|--||||---|||||--  1 [C] COG2086 Electron transfer flavoprotein, beta subunit
--------|-----------|----|----|---||||----------------------------  1 [M] COG2088 Uncharacterized protein, involved in the regulation of septum location
||-|--|||||||-----------------------------------------------------  1 [S] COG2090 Uncharacterized protein conserved in archaea
|||||||||||||||---------------------------------------------------  1 [J] COG2092 Translation elongation factor EF-1beta
|||||||||||||-----------------------------------------------------  1 [K] COG2093 DNA-directed RNA polymerase, subunit E''
-||-|||||||||---|--|-||||-----------|-----||||||||-|||||--||||||--  1 [U] COG2095 Multiple antibiotic transporter
---||||||-|||-------||----||||-----|||--------|--|-----|---|||||--  1 [S] COG2096 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2097 Ribosomal protein L31E
||||||--||--------------------------------------------------------  1 [S] COG2098 Uncharacterized protein conserved in archaea
-|----|||||-|-----------------------------------------------------  1 [R] COG2100 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB
|-|||||||-------|-||||----|||||-----||----||--|-||--||||--||-|||--  1 [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis
|--|--|||||||||---------------------------------------------------  1 [S] COG2106 Uncharacterized conserved protein
----||--|-|||---|----|||-------------|------------------|||-------  1 [R] COG2107 Predicted periplasmic solute-binding protein
-|||--|||||||-----------------|-----------------------------------  1 [R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme
--|-||||||||||--||--||-----||---|-||------|||-|--|-----|------|---  1 [R] COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1
-|----|||-|||---|-------------------------------------------------  1 [T] COG2112 Predicted Ser/Thr protein kinase
|||||||||||||||---------------------------------------------------  1 [R] COG2118 DNA-binding protein
|||-----||----------------------------------------------------|---  1 [S] COG2122 Uncharacterized conserved protein
|-|-||||||||||||--------------------------------------------------  1 [J] COG2123 RNase PH-related exoribonuclease
||||||||||||||||--------------------------------------------------  1 [J] COG2125 Ribosomal protein S6E (S10)
||||||||||-|||||--------------------------------------------------  1 [J] COG2126 Ribosomal protein L37E
--|-----|----------|-|----|||||--||-||----|||||--|---|||---|||||--  1 [S] COG2128 Uncharacterized conserved protein
|||---|||||||---|-------------------------------------------|-----  1 [R] COG2129 Predicted phosphoesterases, related to the Icc protein
--|-||||||---||--|--||--|-----||||||||-|--------|-----------------  1 [F] COG2131 Deoxycytidylate deaminase
|||---||||||||||--------------------------------------------------  1 [JA] COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain
||||----||||------||-|----|||-----|-||-----------------|----------  1 [S] COG2138 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2139 Ribosomal protein L21E
--|---|||---------|-----------------|---------|--------|---||-|---  1 [GR] COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes
----||--|---|--------|-----|||------------|||||-||--||||---|||||||  1 [C] COG2142 Succinate dehydrogenase, hydrophobic anchor subunit
--|---|||----||-----------|---||-|||||----|||-|---||----||-|------  1 [H] COG2145 Hydroxyethylthiazole kinase, sugar kinase family
||||||||||||||||--------------------------------------------------  1 [J] COG2147 Ribosomal protein L19E
|-|||||||---------------------------------------------------------  1 [R] COG2150 Predicted regulator of amino acid metabolism, contains ACT domain
|||---||||||||||--------------------------------------------------  1 [J] COG2157 Ribosomal protein L20A (L18A)
|||-----||--------------------|-----------------------------------  1 [R] COG2158 Uncharacterized protein containing a Zn-finger-like domain
|-------|--------|------------------------------------------------  1 [S] COG2164 Uncharacterized conserved protein
||||||||||-|||||--------------------------------------------------  1 [J] COG2167 Ribosomal protein L39E
-||---|||||||-|---------------------------------------------------  1 [J] COG2178 Predicted RNA-binding protein of the translin family
--------|-|-|-------------|||-----|-|-----|||-|--|-----|-----|----  1 [C] COG2180 Nitrate reductase delta subunit
-----|--|-----------|-----|------|-|--||------|---|||-|-||-|--|---  1 [L] COG2189 Adenine specific DNA methylase Mod
--||--|||--------|-|----||----|-----||----|||||-||--|--|--|||-||--  1 [NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain
|||-----||--------------------------------------------------------  1 [C] COG2218 Formylmethanofuran dehydrogenase subunit C
||||||||||||||||--------------------------------------------------  1 [L] COG2219 Eukaryotic-type DNA primase, large subunit
|||-----||--------------------------------------------------------  1 [R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase
|-||--||||---||-|--|-------||-|-----||----|||-|-||--|----------|--  1 [R] COG2234 Predicted aminopeptidases
-||||||||-|||-----------------------------------------------------  1 [S] COG2237 Predicted membrane protein
||||||||||||||||--------------------------------------------------  1 [J] COG2238 Ribosomal protein S19E (S16A)
||||||--||||------|||-----|||-|----|----------|--|-----|---||||---  1 [H] COG2241 Precorrin-6B methylase 1
||||||--||||------|||-----|||-|----|----------|--|---------||||---  1 [H] COG2242 Precorrin-6B methylase 2
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2243 Precorrin-2 methylase
||||||||||-|-----|-|||----|---||||||||----|||||-||||||||---|||||--  1 [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
---||||||||||-----||------||||||-||||-----|---|--|-----|------||--  1 [S] COG2246 Predicted membrane protein
-|----|||||||-----------------------------------------------------  1 [R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)
-|----|||-|||-----------------------------------------------------  1 [L] COG2254 Predicted HD superfamily hydrolase, possibly a nuclease
|||||||||||||||---------------------------------------------------  1 [J] COG2260 Predicted Zn-ribbon RNA-binding protein
|||||||||||||--|--------------------------------------------------  1 [J] COG2263 Predicted RNA methylase
|||||||||||||-----------------------------------------------------  1 [H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase
-------||----||--|-|||----||||||--||||----|||||-||||---|---|||||--  1 [I] COG2267 Lysophospholipase
--|-----|--||-----||||---|||||------||----|--||-||------------|---  1 [R] COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain
--------|--------|---|--------------------------------------------  1 [R] COG2316 Predicted hydrolase (HD superfamily)
--------|----|-|---|||---||---|---||||-----------|---------|||||--  1 [S] COG2340 Uncharacterized protein with SCP/PR1 domains
----||--|-|||-----||-|---------------------------|-----|-----|-|--  1 [R] COG2366 Protein related to penicillin acylase
--|-----|------------|--------------------|||||-|||||------|||||--  1 [O] COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component
--------|---|-------||----|----|--||------|||---||-|-------|||||--  1 [R] COG2388 Predicted acetyltransferase
------||||--|--------------------------------|--------------------  1 [R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain
|-------|||||-----------------------------------------------------  1 [S] COG2410 Uncharacterized conserved protein
--||||||||-||-----------------------------------------------------  1 [S] COG2412 Uncharacterized conserved protein
------||||-||-----------------------------------------------------  1 [R] COG2413 Predicted nucleotidyltransferase
------|||||||-----------------------------------------------------  1 [S] COG2419 Uncharacterized conserved protein
|-||||--|||||||-----------|-------|----------|---|-----|---||||---  1 [E] COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog
------|||---|------------------------|----------------------------  1 [S] COG2426 Predicted membrane protein
--|---|||-|-|-----------------------------------------------------  1 [S] COG2430 Uncharacterized conserved protein
|-||--|||||||-----------------------------------------------------  1 [S] COG2433 Uncharacterized conserved protein
------|||--||-----------------------------------------------------  1 [C] COG2441 Predicted butyrate kinase
||||||||||--||||--------------------------------------------------  1 [U] COG2443 Preprotein translocase subunit Sss1
||||||||||--------------------------------------------------------  1 [S] COG2450 Uncharacterized conserved protein
|||---||||-|------------------------------------------------------  1 [S] COG2457 Uncharacterized conserved protein
-------||--------|--|---------||-|---|----------------------------  1 [S] COG2461 Uncharacterized conserved protein
-|||--|||---------------------------------------------------------  1 [S] COG2469 Uncharacterized conserved protein
--|---||||||-----||-|---------||-----|----------|--------------|--  1 [R] COG2509 Uncharacterized FAD-dependent dehydrogenases
|||||||||||||-----------------------------------------------------  1 [J] COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain)
--|-|||||-|||-----------------------------------------------------  1 [S] COG2512 Uncharacterized membrane-associated protein/domain
|-----||||--------------------------------------------------------  1 [R] COG2517 Predicted RNA-binding protein containing a C-terminal EMAP domain
||-||||||||||||-||--------||||------------------------------------  1 [J] COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases
||||----|-|||-----------------------------------------------------  1 [K] COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains
--||||--|--||||-||||||----|---|||-|||||-------|--|||-|||||-|||----  1 [P] COG2608 Copper chaperone
|-|-----|--------|------------|-----------------------------------  1 [R] COG2768 Uncharacterized Fe-S center protein
|||||||||------------|--------------------------------------------  1 [C] COG2811 Archaeal/vacuolar-type H+-ATPase subunit H
--------|-----------|-----|----|||||------|||||--|||-|||--||||||--  1 [S] COG2855 Predicted membrane protein
--|-----|-------|-------------------------|||||-||||---|--|-|-----  1 [C] COG2864 Cytochrome b subunit of formate dehydrogenase
-||||||||--||-----------------------------------------------------  1 [NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2875 Precorrin-4 methylase
|||||||||||||-----------------------------------------------------  1 [J] COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG2890 Methylase of polypeptide chain release factors
|||---||||--|-----------------------------------------------------  1 [S] COG2892 Uncharacterized protein conserved in archaea
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [H] COG2896 Molybdenum cofactor biosynthesis enzyme
--------|-------|---------|----------|----------||----------------  1 [T] COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains
--------|-|-------------------------------||||||||||--------------  1 [P] COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit
---|----|----------------------------------------|--||||---|||||||  1 [R] COG2945 Predicted hydrolase of the alpha/beta superfamily
--------|---------------------------------|||||-|----|||------|---  1 [R] COG3042 Putative hemolysin
|||-----||-----------------|||------------|||||-||-|-|||----------  1 [H] COG3161 4-hydroxybenzoate synthetase (chorismate lyase)
---||||||--||------------------------------------|----------------  1 [S] COG3199 Uncharacterized conserved protein
--------|---------|--------|||------------------||-----|---||-||||  1 [I] COG3243 Poly(3-hydroxyalkanoate) synthetase
--------|-----------||-----|---------------------|-----|---||-|---  1 [S] COG3246 Uncharacterized conserved protein
||||----||--------------------------------------------------------  1 [H] COG3252 Methenyltetrahydromethanopterin cyclohydrolase
|||---||||--------||----------------------------------------------  1 [C] COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit
||||||--|||-------------------------------------------------------  1 [R] COG3269 Predicted RNA-binding protein, contains TRAM domain
------|||-----------------------||--------|||-|-|-----------------  1 [S] COG3270 Uncharacterized conserved protein
|-||--||||--|-----------------------------------------------------  1 [S] COG3273 Uncharacterized conserved protein
|||||||||||-||||--------------------------------------------------  1 [J] COG3277 RNA-binding protein involved in rRNA processing
|||---|-|---|------------------|-----|----------|-----------------  1 [R] COG3291 FOG: PKD repeat
--------|-||------------------------------|||-|---||--------------  1 [P] COG3301 Formate-dependent nitrite reductase, membrane component
--|-----|------------------------------------|--||----------|--|--  1 [T] COG3322 Predicted periplasmic ligand-binding sensor domain
--------|-------|--------------------|----------------------------  1 [L] COG3337 Uncharacterized protein predicted to be involved in DNA repair
|--|||--||||------------------------------------------------------  1 [S] COG3356 Predicted membrane protein
---|---|||||------------------------------------------------------  1 [K] COG3357 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon
|-||----||--------------------------------------------------------  1 [R] COG3364 Zn-ribbon containing protein
|-||----||--------------------------------------------------------  1 [S] COG3365 Uncharacterized protein conserved in archaea
----||--|-|||-----------------------------------------------------  1 [S] COG3370 Uncharacterized protein conserved in archaea
--|||||||-||-------|----------------------------------------------  1 [S] COG3372 Uncharacterized conserved protein
----||--|-||-----|------------------------------------------------  1 [S] COG3374 Predicted membrane protein
--|-||--|---------------------------||----------------------------  1 [S] COG3377 Uncharacterized conserved protein
--||||--||--------------------------------------------------------  1 [S] COG3388 Uncharacterized protein conserved in archaea
--||||--|---------------------------------------------------------  1 [S] COG3389 Uncharacterized protein conserved in archaea
--|||||||---------------------------------------------------------  1 [S] COG3390 Uncharacterized protein conserved in archaea
-|||----|---------------------------------------------------------  1 [S] COG3398 Uncharacterized protein conserved in archaea
--||||--|---------------------------------------------------------  1 [S] COG3430 Uncharacterized protein conserved in archaea
----||--|---------------------------||----------------------------  1 [S] COG3465 Uncharacterized conserved protein
--|-----|-----|---||----------||----|----------------------||-----  1 [T] COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
|-|-----|----------------------------------------|-----|---|||||--  1 [S] COG3503 Predicted membrane protein
|-|-----|---------------------|----------------------------|-||---  1 [S] COG3543 Uncharacterized conserved protein
--|-----|------------|-------------------------------------||-|---  1 [S] COG3603 Uncharacterized conserved protein
-||||||||-|||------|-------||--------------||||-----|--|---||-||--  1 [K] COG3609 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain
--||||--|---------------------------------------------------------  1 [S] COG3612 Uncharacterized protein conserved in archaea
--|||||||---------------------------------------------------------  1 [K] COG3620 Predicted transcriptional regulator with C-terminal CBS domains
------|||---------------|---------------------|-|--|--------------  1 [C] COG3630 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit
||||||||||||||||--------------------------------------------------  1 [T] COG3642 Mn2+-dependent serine/threonine protein kinase
---|----|----------------------|||||||----------------------------  1 [S] COG3679 Uncharacterized conserved protein
--------|------------------||---------------------------------|---  1 [S] COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase
-||-----|||---------------||||||-|-|-------------|---||-----------  1 [T] COG3830 ACT domain-containing protein
|||||||||||||---||||||--|-||||||||||||-||||||||-||-||--|--|||||---  1 [G] COG3839 ABC-type sugar transport systems, ATPase components
--||----|-|-|----|||||--|||---||||||-||||||||||-||||-|||--||||||--  1 [E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components
---|--|||-|-|----|-|-|--||----||||-||-||||-------|-----|---||||---  1 [R] COG3845 ABC-type uncharacterized transport systems, ATPase components
--------|---------------------|-----|-----------------------------  1 [S] COG3863 Uncharacterized distant relative of cell wall-associated hydrolases
--|-----|--------|------------|-----------------------------------  1 [S] COG3875 Uncharacterized conserved protein
----||--|--|------------------------------------------------------  1 [K] COG3888 Predicted transcriptional regulator
|-------||--------------------------------------------------------  1 [R] COG4001 Predicted metal-binding protein
------||||--------------------------------------------------------  1 [S] COG4003 Uncharacterized protein conserved in archaea
--|-||--||--------------------------------------------------------  1 [S] COG4004 Uncharacterized protein conserved in archaea
|-|-----||--------------------------------------------------------  1 [S] COG4012 Uncharacterized protein conserved in archaea
|-------||--------------------------------------------------------  1 [S] COG4030 Uncharacterized protein conserved in archaea
--||----||--------------------------------------------------------  1 [R] COG4031 Predicted metal-binding protein
--------|||||-----------------------------------------------------  1 [S] COG4034 Uncharacterized protein conserved in archaea
|-------||--------------------------------------------------------  1 [S] COG4068 Uncharacterized protein containing a Zn-ribbon
--||----||--------------------------------------------------------  1 [S] COG4083 Predicted membrane protein
--|-----||||------------------------------------------------------  1 [S] COG4089 Predicted membrane protein
--------|-----------|----|----------------|||||---||--------------  1 [H] COG4145 Na+/panthothenate symporter
--------|-------|--|-|----|---------||----|||||-||--|--|----------  1 [R] COG4147 Predicted symporter
|-|-|||||-||------------------|------------------------|------||--  1 [C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits
--------|-|--------------------------------------------|----|-|---  1 [S] COG4274 Uncharacterized conserved protein
--------|-|||-----------------------------------------------------  1 [S] COG4343 Uncharacterized protein conserved in archaea
---|--|||-|-|----|-|-|--||----||||-||-||||-------|-----|---||||---  1 [R] COG4603 ABC-type uncharacterized transport system, permease component
--|||||||-|||---||--||||-||---||||||||-||||||||-||||---||||||||---  1 [E] COG4608 ABC-type oligopeptide transport system, ATPase component
---|----|-------|--|---------------------------------------||-----  1 [S] COG4711 Predicted membrane protein
---|----|----------------------------|-----------|-|--------------  1 [S] COG4729 Uncharacterized conserved protein
--|-||--|---------------------------------------------------------  1 [K] COG4738 Predicted transcriptional regulator
--|-----||--------------------------------------------------------  1 [S] COG4739 Uncharacterized protein containing a ferredoxin domain
--||----|---------------------------------------------------------  1 [O] COG4745 Predicted membrane-bound mannosyltransferase 
|-|-----|---------------------------------------------------------  1 [R] COG4747 ACT domain-containing protein
--||----|---------------------------------------------------------  1 [S] COG4749 Uncharacterized protein conserved in archaea
--------|-|-|-----------------------------------------------------  1 [R] COG4756 Predicted cation transporter
---|--|||--|-||--|--||----||||------||-----------|-----|---|||||||  1 [I] COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
-||-----|---------------------------------------------------------  1 [K] COG4800 Predicted transcriptional regulator with an HTH domain
--||----||--------------------------------------------------------  1 [R] COG4801 Predicted acyltransferase
|-|-----|---------||----------------------------------------------  1 [C] COG4802 Ferredoxin-thioredoxin reductase, catalytic subunit
|-|-----|---------------------------------------------------------  1 [S] COG4855 Uncharacterized protein conserved in archaea
--|-||--|---------------------------------------------------------  1 [S] COG4860 Uncharacterized protein conserved in archaea
--|-----|-----------|---------|---------------------|-------------  1 [O] COG4870 Cysteine protease
|-|-----|---------------------------------------------------------  1 [S] COG4871 Uncharacterized protein conserved in archaea
-|------|-|-------------------------------------------------------  1 [R] COG4880 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats
--------|-|-|-----------------------------------------------------  1 [S] COG4881 Predicted membrane protein
|-|-----|---------------------------------------------------------  1 [S] COG4883 Uncharacterized protein conserved in archaea
--||----|---------------------------------------------------------  1 [S] COG4885 Uncharacterized protein conserved in archaea
--------|-|-|-----------------------------------------------------  1 [S] COG4904 Uncharacterized protein conserved in archaea
---|||--||-||----|||||----||||||--||||----|||||--|-----|---|||||--  1 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily
|||---|-|-------||--|---|-------|-------------|-||-|------|-------  1 [C] COG5016 Pyruvate/oxaloacetate carboxyltransferase
||||||||||||||||--------------------------------------------------  1 [J] COG5256 Translation elongation factor EF-1alpha (GTPase)
||||||||||||||||--------------------------------------------------  1 [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)
|--|----|-||------------------------------------------------------  1 [R] COG5258 GTPase
--------|--------------------------------------------------||||---  1 [S] COG5402 Uncharacterized conserved protein
--|---|||---------------------------------------------------------  1 [S] COG5423 Predicted metal-binding protein
------|-|-|-------|-------|---------|-----------------------------  1 [S] COG5428 Uncharacterized conserved small protein
--------|--||-----------------------------------------------------  1 [S] COG5431 Uncharacterized metal-binding protein
--------|---------------------------------------------------|||---  1 [S] COG5436 Predicted integral membrane protein
|-------|--||-----------------------------------------------------  1 [S] COG5440 Uncharacterized conserved protein
--------|-|--------|-------||-------------------------------------  1 [S] COG5551 Uncharacterized conserved protein
-||-----|---------------------------------------------------------  1 [S] COG5561 Predicted metal-binding protein
------|||-|-|-----------------------------------------------------  1 [K] COG5625 Predicted transcription regulator containing HTH domain
--|-----|-----------------|--------||--------------------------|--  1 [S] COG5658 Predicted integral membrane protein
----||--|--|------------------------------------------------------  1 [S] COG5666 Uncharacterized conserved protein