(order) Methanococcales - 1 genome Functional categories Fun All J A K L B D Y V T M N Z W U O C G E F H I P Q R S COGs 1,117 152 2 48 67 3 10 -  7 9 25 10 -  -  18 38 84 42 91 46 93 15 48 6 173 188 proteins 1,519 159 2 66 114 7 23 -  19 11 37 19 -  -  28 51 148 54 109 52 109 18 68 12 282 223 Distribution of COGs by number of proteins proteins 1 2 3 4 5 6 7 9 13 15 19 23 COGs 899 149 35 16 8 1 4 1 1 1 1 1

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
|||---||--||-----||||------------------------|------------|------- 23 [R] COG1672 Predicted ATPase (AAA+ superfamily)
-|--||||-|--||--|-||-|-----|||------|----------------------------- 19 [L] COG1372 Intein/homing endonuclease
|||||||||||||||-||||||||-|||||||||||||----|||||-|||||||||||||||||| 15 [R] COG0517 FOG: CBS domain
|||-|||||||||----|||||--------|-----|-----|||||-|||||||||||||-|--- 13 [C] COG1145 Ferredoxin
|||||||||--|-|||||||||||||----||||||||----|||||-||-|||||||||||||||  9 [R] COG0457 FOG: TPR repeat
|||||||||||||||||||||||||-||||||||||||----||||||||||||||||||||||||  7 [QR] COG0500 SAM-dependent methyltransferases
-|||||||-|||----||||-|---|-||-------------|||-|-----|---||--------  7 [L] COG0675 Transposase and inactivated derivatives
||||||-|||||-----|||-|----|||||-----------|||-|-||--|--|||||||||||  7 [C] COG1146 Ferredoxin
|||------|------|-|-----------------------------------------------  7 [R] COG1719 Predicted hydrocarbon binding protein (contains V4R domain)
-||-----|--------||--|-------------------------------|-----|---|--  6 [R] COG1669 Predicted nucleotidyltransferases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  5 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
|||||||||||||||||||||||||-||||-|||||||||||||||||||||||||||||||||||  5 [L] COG0470 ATPase involved in DNA replication
|||||||||||||---||||||----|||||||-||||----|||||-||-|||||--||||||--  5 [K] COG0640 Predicted transcriptional regulators
|||-|||||||||----|||||-----||-||-----|----|||-|-||------------|---  5 [C] COG1032 Fe-S oxidoreductase
|||-----||--------||----------------------------------------|-----  5 [C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit
||----||-|--------------------------------------------------------  5 [S] COG1991 Uncharacterized conserved protein
||||--||||---|||--------------------------------------------------  5 [B] COG2036 Histones H3 and H4
-||---------------|--|-------------------------------|-----|---|--  5 [S] COG2361 Uncharacterized conserved protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  4 [K] COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
||||---||----------|-------||--|||||--|||-|||-|-|||||||||||-||-|-|  4 [V] COG0286 Type I restriction-modification system methyltransferase subunit
|||||||||||||||-|||||||||-||||||||||||----|||||-||||||||||||||||||  4 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase
||||||||||||||||||||||---|||||||||||||----|||||-||||||||||||||||||  4 [M] COG0438 Glycosyltransferase
||-|--||||------||-|----||-||||-----||----------||-----||||-------  4 [D] COG0455 ATPases involved in chromosome partitioning
-||||||||-|||----|||||----||||||||||||----|||||-||||---|||||||||--  4 [P] COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component
||||-|-||----------|-------||--|||||--|||||||-|-|||||---|||-||-|-|  4 [V] COG0732 Restriction endonuclease S subunits
-|-||||----------|-|||----------|--|-|----|||||-|-|-||-|||-|||||--  4 [L] COG0863 DNA modification methylase
|||---||||-|-----|||------|||||-|-||||----|||||--|-----|---|||||--  4 [G] COG1082 Sugar phosphate isomerases/epimerases
||||||||||-|||--||||-|----|||-||---|||||--|||||-|||-||||||||||||||  4 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component
||||||||||||||||--------------------------------------------------  4 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family
-||-|||||-|||----|-|-|---|--|-||||||||----|||||-||-|---|----|-|---  4 [C] COG1254 Acylphosphatases
|||---|||||||---||------------|---|-----------|---|--------||----|  4 [R] COG1708 Predicted nucleotidyltransferases
||------||------|----|-----||------------------------||-----------  4 [R] COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid
-||---|-|---|-----|||------||----|--------|--||-|------|---||-----  4 [JD] COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system
-|||----||--------------------------------------------------------  4 [S] COG3366 Uncharacterized protein conserved in archaea
|||-||-||||||||-||||-|----||||||-|||||----||||||||||||||--||||||--  3 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
|||--|||||||-||-||||-|----|||||--|||||----||||||||||||||--||||||--  3 [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases
||||----||--------||----------|----|----------|---|----------|----  3 [P] COG0310 ABC-type Co2+ transport system, permease component
||||||||||||||||---|----------------------|||||-||----------------  3 [L] COG0417 DNA polymerase elongation subunit (family B)
|||---|||-------|||||---------|-----------|||-|--|-----|----------  3 [C] COG0426 Uncharacterized flavoproteins
|||||||||||||---||||-|-----||---|----|----||||---|-|---|---|||||--  3 [R] COG0433 Predicted ATPase
||||||||||||||||||||||---||||||||||||||||||||||-||||||||||||||||||  3 [M] COG0463 Glycosyltransferases involved in cell wall biogenesis
|||------|---||-|||||--|--|||||---|-||----||||||||||||||||||-|||--  3 [H] COG0502 Biotin synthase and related enzymes
||||||||||||----|||||||||||---||||||||----|||||-||||||||||||||||||  3 [L] COG0608 Single-stranded DNA-specific exonuclease
-||||||||-|||----|||||----|---|||||||||---|||||-||||---|||||||||--  3 [P] COG0609 ABC-type Fe3+-siderophore transport system, permease component
||||---||----------|-----------||-||--|||-------||||||--|||-||-|-|  3 [V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
|||||||||-|-|---|||||||||-||||-----|||----||||||||||||||||||||||||  3 [OU] COG0616 Periplasmic serine proteases (ClpP class)
-||||||||-|||---------------------------------------|---||-|||||||  3 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis
|||||||||||||||-|||||-----|||||-----------|||-|--|--||||---|||||--  3 [C] COG0644 Dehydrogenases (flavoproteins)
|||||||||||||-||||||||--|||||-||||||||----||||||||--||||||||||||||  3 [M] COG0668 Small-conductance mechanosensitive channel
||||--||-|-|-||||-||||--|-||||||||||||----|||||-|||||--|||-|||||||  3 [I] COG0671 Membrane-associated phospholipid phosphatase
|||---||||-|----|-||----------|-----------|||-|---------|||-------  3 [C] COG0680 Ni,Fe-hydrogenase maturation factor
|||||||||||||---||||-|---|||||||||||-||-|||||||-||--|--|---|||||--  3 [P] COG0704 Phosphate uptake regulator
||||--|||||||-----------------|----|||----|||-|---------||---|-|--  3 [K] COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain
||||----|||||---|||||||||||||-||||||||||||||||||||||||||||||||||||  3 [V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component
|||---||||-------|||----------------------|||||-------------------  3 [C] COG1142 Fe-S-cluster-containing hydrogenase components 2
|||---||-|-------|--|---------||||||------|||||-||||---|----------  3 [F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase
-||||||||-||-----|------------------------------------------------  3 [M] COG1361 S-layer domain
-||||||||--||-----------------------------------------------------  3 [N] COG1681 Archaeal flagellins
||||||--|--||-----||||----|||-||--||||----|||||-||-||--|--|||-||--  3 [K] COG1733 Predicted transcriptional regulators
||-----||--------||||---|--||-|-----------|||-|--|--||||-------|--  3 [C] COG1773 Rubredoxin
-|----|-|---------------------------------------------------------  3 [R] COG1800 Predicted transglutaminase-like proteases
|||-----||--------------------------------------------------------  3 [S] COG1810 Uncharacterized protein conserved in archaea
|||---||||--------||----------------------------------------------  3 [C] COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit
||||--||||------||||-|----|||-||||||||----|||||-||||||||--|---||--  3 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
|||||||||||||-------------||--|--------------|---|-|---|---||-||--  3 [NU] COG2064 Flp pilus assembly protein TadC
|||---||||--------||----------------------------------------------  3 [C] COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit
-|-|----|-------|---------|-------||---------|------|--------|||--  3 [L] COG3316 Transposase and inactivated derivatives
|||-----||--------------------------------------------------------  3 [D] COG3640 CO dehydrogenase maturation factor
|||------|--------------------------------------------------------  3 [R] COG4087 Soluble P-type ATPase
|||-||--||-|-||-||||-|----|||-||--|||||---|||||--|--||||---|||||--  2 [P] COG0004 Ammonia permease
||||||-|||---|||--||-|----|||--|-||||-----|||||-||-||------|--|---  2 [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
||||||||||||||||||||-|----||||||--|||-----|||||-||--||||||||||||--  2 [G] COG0063 Predicted sugar kinase
||||--||||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  2 [E] COG0065 3-isopropylmalate dehydratase large subunit
|||---||||||-||-||||-|----||||||-|||||----||||||||||||||--||||||--  2 [E] COG0066 3-isopropylmalate dehydratase small subunit
||||--||||--||----||-------||--|---|-|----||||--|-|---------|||---  2 [E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  2 [G] COG0148 Enolase
-||||-||-||||||---||||----|||-|-----||----||||||||--||||---|||||--  2 [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes
-|||--|||-|||-----||-|---------------|--||||||||||||||||---|||||--  2 [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)
||||||||||------||||||--||||||||||||||-|||||||||||||||||||||||||||  2 [D] COG0206 Cell division GTPase
||-||||||||||---|-||-|----|||-------||----|||||-||||---|||||||||--  2 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
||----||-||||-|---||------|---|-||--||||--|||-|-|-|-||||||--|-||--  2 [L] COG0270 Site-specific DNA methylase
||||||--||---|||--------||----------------||||||||||||||---|||||||  2 [J] COG0293 23S rRNA methylase
|||||||||||||---|-||-|----|||||---||||----|||||-||||---|||||||||--  2 [H] COG0303 Molybdopterin biosynthesis enzyme
|||-|||||||||---||||-|-----||-|------|----||||||||||||||---|||||--  2 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs
|||-----||------||||-|----|||-||---||-----|||||-||||||||---|||||--  2 [E] COG0347 Nitrogen regulatory protein PII
-||-||--||-|------||----------|-----------|||-|-||||-|||||||||||--  2 [C] COG0348 Polyferredoxin
|||||||||||-||||----------||||||---|||----|||||-||--|-------|-|---  2 [E] COG0367 Asparagine synthase (glutamine-hydrolyzing)
|||-----||----|-|-||||----|||-----|--||---|||||--||----||||||||---  2 [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase
||||--||||------||||------|||||---|||-|||||||-|--|--|--|---||||---  2 [S] COG0392 Predicted integral membrane protein
|||||||||--|-----|||-------|||-|---|-|----|||-|-|--|-----------|--  2 [S] COG0393 Uncharacterized conserved protein
|||||||||||||||-||||-|----|---|--|---|----|||||--||||--|||||||||--  2 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
||||||--||||----|||||-------------|-|-----||||||||||-|||--||||||--  2 [O] COG0425 Predicted redox protein, regulator of disulfide bond formation
||||||||-||||||||||||||||-||||||||||||----||||||||||||||||||||||--  2 [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
||||||||||||-||-||||||---|||||||-|||||----|||||-||||||||||||||||--  2 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  2 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  2 [L] COG0468 RecA/RadA recombinase
||-|--||-||--||-|-|--|||--|---|||||-||----|||||-||||||||||||||----  2 [P] COG0471 Di- and tricarboxylate transporters
|||---||||||-||-||||-|----||||||--||||----||||||||||||||--||||||||  2 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  2 [GEPR] COG0477 Permeases of the major facilitator superfamily
||||--||||||||--||||-|---|||||-|||||||----|-||||||||||||--||||||||  2 [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
||||||||||||||||||||||----||||||||||||----||||||||||||||||||||||--  2 [R] COG0491 Zn-dependent hydrolases, including glyoxylases
||-|||||-|--|||-||||||-|-|||||||||||||----||||||||||||||||||||||--  2 [F] COG0516 IMP dehydrogenase/GMP reductase
|||||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins
||||||--||||||||--|||-||--|||||||||||||||||||||-|||||--|---|||||||  2 [E] COG0531 Amino acid transporters
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0532 Translation initiation factor 2 (IF-2; GTPase)
|||||||||||||---||||-|-----||-||--|-||-----------|-----|----|-|---  2 [R] COG0535 Predicted Fe-S oxidoreductases
|||||||||--------|--|-|||-----|||||||||-|||||||||||||||||||-------  2 [L] COG0551 Zn-finger domain associated with topoisomerase type I
|||||||||||||---||||||--|-|||||--|-||-----|||||-||--||||||||||||||  2 [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase
||||----||||-----||||||||-|||-||||||||----|||||-||-|-|||--||||||--  2 [V] COG0577 ABC-type antimicrobial peptide transport system, permease component
|||||||||--||---||||||||--||||||||||||||--|||||-||||||||||||||||||  2 [L] COG0582 Integrase
||------||------|-||||----||||||||||||----|||||-||||||||--||||||--  2 [K] COG0583 Transcriptional regulator
|||||||||||||||||----|--------------------|||||-||||----|||-------  2 [S] COG0585 Uncharacterized conserved protein
|||||||||||||-|-|-||-|----||||-|||||||----|||||-||||-|||---|||||||  2 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins
|||-||--||-|-||--||--|----|||--|---|||-------|---||-||||---|||||--  2 [S] COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
||||----|--||---||||-|--------|------|----|||||-||||-|||----------  2 [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family)
-|||--|||||-|---||||||--|||||-||||||||||||------|-----------------  2 [R] COG0618 Exopolyphosphatase-related proteins
||||--||||-||----|||||----||||||||||||||||-||-|---|--------|||----  2 [P] COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
||||--|||||||||--|--|---|----|||||||||-||||||||-||----------------  2 [R] COG0622 Predicted phosphoesterase
-|--|||||||||||-||--||-|--||||||||||||----||||||||||||||||||||||||  2 [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases
||||||||||||||||-----------|||------------------------------------  2 [O] COG0638 20S proteasome, alpha and beta subunits
|||--|||-|-|-----|---------||-------------|||-|-------------------  2 [C] COG0650 Formate hydrogenlyase subunit 4
|||-----||-|-||-|---||-----||||--|||||----||-||-||--|--|---|||-|-|  2 [R] COG0655 Multimeric flavodoxin WrbA
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  2 [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit
|||||||||||||---||||-|---||||||---||||----|||||-||--|--|---|||||--  2 [R] COG0714 MoxR-like ATPases
|||||||||||||---|-||--||--|||||------|----||||||-|||||||||||||||||  2 [F] COG0717 Deoxycytidine deaminase
-|||--|||-||------||-|---------||---------|||||-||--|--||||-|-|---  2 [R] COG0727 Predicted Fe-S-cluster oxidoreductase
|||||||||||||||--||||---------|-------------------------|||-------  2 [C] COG0731 Fe-S oxidoreductases
|||------|-|----|--|||--------||||||||----|||||-||||-|||||||||----  2 [O] COG0826 Collagenase and related proteases
-|||||----|----------|---||---|-----|-|----||-|---|---|-|||----|--  2 [V] COG1002 Type II restriction enzyme, methylase subunits
-|||---||--|----|-||------|||---|---||----|||||-||-||--|--||||||||  2 [M] COG1004 Predicted UDP-glucose 6-dehydrogenase
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  2 [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit
|||||||||||||---|||||---|--||-||--||-|----|||||-|------||||---||--  2 [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit
|||-----||--------------------------------------------------------  2 [C] COG1036 Archaeal flavoproteins
|||||||||||||-------||--|-----------------|||||-|||||||||||-------  2 [O] COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
||||||--|||-|---||||||||---||||------|----|||||-|-------|||-------  2 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes
-|----||-|--|---||--||||-------||||||-----||||||||||||||---||||---  2 [R] COG1092 Predicted SAM-dependent methyltransferases
||------||---------|----------------------------------------------  2 [R] COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold
-|----||---|-------||-----------------------------------||--------  2 [R] COG1106 Predicted ATPases
|||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||  2 [G] COG1109 Phosphomannomutase
-|----|||||||---||------------------------------------------------  2 [L] COG1110 Reverse gyrase
-||||||||--||----|||||----|---|-|||||||-|||||||-||||---|||||||||--  2 [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components
||||--|||||||----|||||--|-||||||||||||||||-||-|-|-|----|---|||----  2 [P] COG1122 ABC-type cobalt transport system, ATPase component
|||-|----|-|------|||-----||||----|-------|||||-|------|||-||-|---  2 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase
|||---||||-------|------------------------------------------------  2 [C] COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain
|||-----||-|----|-------------------------------------------------  2 [C] COG1150 Heterodisulfide reductase, subunit C
|||----|||-------|--|---------|-----------|||||-------------------  2 [C] COG1151 6Fe-6S prismane cluster-containing protein
|||-----||--------------------------------------------------------  2 [C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit
|||-|||||||||---||--|------||-||||||------|||||-||||---|----------  2 [O] COG1180 Pyruvate-formate lyase-activating enzyme
|||---|||-|||---||--|-----------|----|----|||||----|--------------  2 [R] COG1203 Predicted helicases
|||||||||||||||||-------------------------|----------------||-----  2 [R] COG1204 Superfamily II helicase
|||---||||||-||----|-|----|||-------||-----||---------------|-----  2 [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
|||---||||-------|------------|---------------|-------------------  2 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II
-||------|------|-------------------------|||||-||||||||--||||||||  2 [S] COG1238 Predicted membrane protein
-|--|-|||----||-----------|||--||||-------|||-|-|-||-|------------  2 [P] COG1275 Tellurite resistance protein and related permeases
|||---||||--|-----||-------||-|---|-||-----------|------------||--  2 [S] COG1300 Uncharacterized membrane protein
-||-|-||--||-----|--|------||----|-|--------------|-----|||---|--|  2 [R] COG1373 Predicted ATPase (AAA+ superfamily)
|||---||-|--------------------------||----------------------------  2 [S] COG1379 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  2 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
||||-----|--------||-------||--------------------|-----|---||||---  2 [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases
|||-|||||||------|------------|-----------------|-----------------  2 [S] COG1433 Uncharacterized conserved protein
||||--|||-------|---||----|---|-------||--|||||-||--||||||||||||-|  2 [R] COG1451 Predicted metal-dependent hydrolase
-||---|||-||------||-|-----||-----------------|---|-|--|---||-||-|  2 [R] COG1487 Predicted nucleic acid-binding protein, contains PIN domain
||||||--||-|------||||-----||-|----|-|--------|-||-----|---|||||--  2 [H] COG1492 Cobyric acid synthase
||||--|||--------|---|---|-|||------|-----|||||-||--|--|-------|||  2 [S] COG1520 FOG: WD40-like repeat
|||||||||||||--------|----|||-|-----||----|||||-||||-|||---|||||--  2 [K] COG1522 Transcriptional regulators
-|----|||-------|-------------------------------------------------  2 [R] COG1568 Predicted methyltransferases
|||||||||||||-----------------------------------------------------  2 [R] COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
|||--||||-------||------------------------------------------------  2 [L] COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||----|||-|-----|-||---------|-----|---------------------|-------  2 [C] COG1592 Rubrerythrin
|||-----||--------------------------------------------------------  2 [C] COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit
||--|||||--||-----------------------------------------------------  2 [S] COG1630 Uncharacterized protein conserved in archaea
||----|||-||------------------------------------------------------  2 [S] COG1673 Uncharacterized protein conserved in archaea
|||||||||||||--|||-|-|----|||-|------|----|||-|--|-----|----------  2 [S] COG1690 Uncharacterized conserved protein
|||||||||||||||-|-------------------------------------------------  2 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding
||||----||--------------------------------------------------------  2 [R] COG1745 Predicted metal-binding protein
|||||||||||||-----------------------------------------------------  2 [R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain
-|||----|---|-----||-------------|--------------------------------  2 [S] COG1808 Predicted membrane protein
||----||||||||----------------------------------------------------  2 [R] COG1818 Predicted RNA-binding protein, contains THUMP domain
||----||----------------------------------------------------------  2 [S] COG1822 Predicted archaeal membrane protein
||||--||||-||---|--|--||------------------|||||----|-------||-|---  2 [G] COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes
-|----|||-|||--------|-----||-------------------------------|-----  2 [R] COG1848 Predicted nucleic acid-binding protein, contains PIN domain
||||||||||--------------------|-----||----------------------------  2 [S] COG1873 Uncharacterized conserved protein
-||---|-|--------|------------------------------------------------  2 [S] COG1895 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
|||-----||--------||----------------------------------------------  2 [S] COG1900 Uncharacterized conserved protein
|||-----||------||--|---------||---|------|||---------------------  2 [I] COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)
||||||-||||||---||||-|-----||-|----|||----------|----|||||--|-||--  2 [R] COG1994 Zn-dependent proteases
|||-----||-|----|-||--------------------------------------|-------  2 [C] COG2048 Heterodisulfide reductase, subunit B
-||-|||||||||---|--|-||||-----------|-----||||||||-|||||--||||||--  2 [U] COG2095 Multiple antibiotic transporter
|||------|--------|-----------------------------------------------  2 [R] COG2144 Selenophosphate synthetase-related proteins
-|----||-|--------|--|---------------------------|-----|----|-|---  2 [O] COG2192 Predicted carbamoyl transferase, NodU family
|||-----||--------------------------------------------------------  2 [C] COG2218 Formylmethanofuran dehydrogenase subunit C
|||-----|||-------------------|---------------|-------------------  2 [C] COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits
||||||||||-|-----|-|||----|---||||||||----|||||-||||||||---|||||--  2 [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
-||------||||-----------------------------|||||-|-----------------  2 [R] COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain
-||---||--||-||----|-|----|---------------||||--||----------------  2 [T] COG2453 Predicted protein-tyrosine phosphatase
||||||||||||||||--------------------------------------------------  2 [R] COG2520 Predicted methyltransferase
-|----------------------------------------|||-|--|--------|-------  2 [R] COG2603 Predicted ATPase
-|-----||---|-----------------------------------------------------  2 [S] COG2880 Uncharacterized protein conserved in archaea
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  2 [H] COG2896 Molybdenum cofactor biosynthesis enzyme
|||--|||-|-|---------------||-------------|||-|-------------------  2 [C] COG3260 Ni,Fe-hydrogenase III small subunit
|||--|||-|-|---------------|--------------|||-|-------------------  2 [C] COG3261 Ni,Fe-hydrogenase III large subunit
-||-||---|-|----|-------------------------|||-|--|||------|-|-----  2 [J] COG3276 Selenocysteine-specific translation elongation factor
-|-|||||----------------------------------------------------------  2 [N] COG3351 Putative archaeal flagellar protein D/E
-|||----||-|------------------------------------------------------  2 [K] COG3355 Predicted transcriptional regulator
-||-||--|-|||-----------------------------------------------------  2 [K] COG3432 Predicted transcriptional regulator
|||-|||||||||---||---|--------------------------------------------  2 [G] COG3635 Predicted phosphoglycerate mutase, AP superfamily
-|----||-|--|-----------------------------------------------------  2 [L] COG3780 DNA endonuclease related to intein-encoded endonucleases
||-------|--------------------------------------------------------  2 [R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase
|||------|--------------------------------------------------------  2 [H] COG4054 Methyl coenzyme M reductase, beta subunit
|||------|--------------------------------------------------------  2 [H] COG4055 Methyl coenzyme M reductase, subunit D
|||------|--------------------------------------------------------  2 [H] COG4057 Methyl coenzyme M reductase, gamma subunit
|||------|--------------------------------------------------------  2 [H] COG4058 Methyl coenzyme M reductase, alpha subunit
||-------|--------------------------------------------------------  2 [S] COG4075 Uncharacterized conserved protein, homolog of nitrogen regulatory protein PII
-||-----|---------------------------------------------------------  2 [S] COG4818 Predicted membrane protein
||----||-|----------------|||-|--------------|---|-||--|---||-||--  2 [U] COG4962 Flp pilus assembly protein, ATPase CpaF
-||---||-----------------------------------------|----------------  2 [S] COG5306 Uncharacterized conserved protein
-||-----|---------------------------------------------------------  2 [S] COG5561 Predicted metal-binding protein
||||||--|||||-|-|-||||||--|||||---||||----|||||-||-|||||||||||||--  1 [H] COG0001 Glutamate-1-semialdehyde aminotransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase
||-|||-|-||-|||-|-|||------|||-----|-|----------------------------  1 [P] COG0003 Oxyanion-translocating ATPase
|||||||||||||||-||||-------||||-||-|||----|--||--|--|------||-|---  1 [F] COG0005 Purine nucleoside phosphorylase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [E] COG0006 Xaa-Pro aminopeptidase
||||||--|||||||-|-||||----|||||---||||----||||||||--||||---|||||--  1 [H] COG0007 Uroporphyrinogen-III methylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||---|||||||  1 [J] COG0009 Putative translation factor (SUA5)
|||||||||||||||---||||--------|-|-|-||----|||-|-||-|||||||-||||---  1 [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family
||-||||||||--|--|||-------|||-|--||-||----------------------------  1 [S] COG0011 Uncharacterized conserved protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0012 Predicted GTPase, probable translation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0013 Alanyl-tRNA synthetase
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0015 Adenylosuccinate lyase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit
||||||||||||||||--||||--||----|||||||||||||||||||-|||-------------  1 [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0018 Arginyl-tRNA synthetase
|||-||--||---||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0019 Diaminopimelate decarboxylase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [I] COG0020 Undecaprenyl pyrophosphate synthase
|||||||||||||||---||----------------------|||||-||||--------------  1 [J] COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [J] COG0024 Methionine aminopeptidase
-|----||---|------||------|||-------|-----|||||-||-|--------------  1 [F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0030 Dimethyladenosine transferase (rRNA methylation)
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase
-|--||-------||||||||||||-||||||||||||||||||||||||||||||||||||||--  1 [G] COG0036 Pentose-5-phosphate-3-epimerase
-|||||||||-||||-|-||||----|||-||||---|----|||||-|-||-|||---|-|||--  1 [P] COG0038 Chloride channel protein EriC
||||||--|||||||-||||||||-|||||||||||||-||||||||-|-|||--|--||||||||  1 [C] COG0039 Malate/lactate dehydrogenases
||||----||||-||-||||-|----||||||--||||----|||||||||||||---||||||--  1 [E] COG0040 ATP phosphoribosyltransferase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
||||----||---|||||||||||||||||||||||||----|||||-||||||||||||||||||  1 [J] COG0042 tRNA-dihydrouridine synthase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases
|||||||||||||||-||||||----||||||||||||----|||-|--|--|--|||||||||--  1 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--||||||||  1 [C] COG0045 Succinyl-CoA synthetase, beta subunit
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0048 Ribosomal protein S12
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0049 Ribosomal protein S7
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0051 Ribosomal protein S10
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0052 Ribosomal protein S2
||||---||||||||-||||||---||||-||||||||----|||||-||-|---|--||||||||  1 [P] COG0053 Predicted Co/Zn/Cd cation transporters
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0054 Riboflavin synthase beta-chain
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||--  1 [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
-||---||--||-|--|-||||||--|||-||||--||----|||||-||||-------||-|---  1 [G] COG0058 Glucan phosphorylase
|||----|||||-|--||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EH] COG0059 Ketol-acid reductoisomerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0060 Isoleucyl-tRNA synthetase
|||||||||||||||||||||---|||||||||||||||-||||||||||||||||||||||||||  1 [G] COG0061 Predicted sugar kinase
|||||||||||||||-||||-|----|||||-----------|||||-||--|--|||||||||--  1 [S] COG0062 Uncharacterized conserved protein
||||----||-||||-||||||||||||||||||||||||||-------|---|||||||||||||  1 [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0067 Glutamate synthase domain 1
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0068 Hydrogenase maturation factor
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0069 Glutamate synthase domain 2
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0070 Glutamate synthase domain 3
|||||||||||||||-||||-|-----||||---|-||----||||||||--|--|---|||||||  1 [O] COG0071 Molecular chaperone (small heat shock protein)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [R] COG0073 EMAP domain
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--||||||||  1 [C] COG0074 Succinyl-CoA synthetase, alpha subunit
||||||||||||||--||||-|--------||--|-||--------|-||------||-||-||--  1 [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase
||||||--||||-||-||||-|----||||||-|||||----|||-||||||||||--||||||--  1 [E] COG0077 Prephenate dehydratase
|||||||||||||||-||||-|---|||||||||||||--|-||||||||||||||--||||||--  1 [E] COG0078 Ornithine carbamoyltransferase
|||||||||||||||-||||||----||||||--||||----||||||||||||||--||||||--  1 [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0080 Ribosomal protein L11
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0081 Ribosomal protein L1
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0082 Chorismate synthase
-|-|||||-||||||-||||-|----||||||-|||||----|||||||-|||---|||-------  1 [E] COG0083 Homoserine kinase
|||---||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0084 Mg-dependent DNase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0087 Ribosomal protein L3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0088 Ribosomal protein L4
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0089 Ribosomal protein L23
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0090 Ribosomal protein L2
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0091 Ribosomal protein L22
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0092 Ribosomal protein S3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0093 Ribosomal protein L14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0094 Ribosomal protein L5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0096 Ribosomal protein S8
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0097 Ribosomal protein L6P/L9E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0098 Ribosomal protein S5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0099 Ribosomal protein S13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0100 Ribosomal protein S11
|||||||||||--||||||||||||||||||||||||||-||||||||||||||||||||||||||  1 [J] COG0101 Pseudouridylate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0102 Ribosomal protein L13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0103 Ribosomal protein S9
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0104 Adenylosuccinate synthase
|||||||||||||||||-||-||||||||||--|||||----|||||-||||||||||||||||||  1 [F] COG0105 Nucleoside diphosphate kinase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0107 Imidazoleglycerol-phosphate synthase
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase
||||---|-||--||--|||-|||--||||||||||||----|||-|-||-|-|||--||||||-|  1 [R] COG0110 Acetyltransferase (isoleucine patch superfamily)
|||||||||||||||-||||-|----||||||--||||----|||||-|||||--|||||||||--  1 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
||||||||||||||||||||-|||||||||||||||||-|||||||||||||||||||||||||||  1 [E] COG0112 Glycine/serine hydroxymethyltransferase
||||||--|||||||-|-||||||--|||||---||||----|||||-||-|||||||||||||||  1 [H] COG0113 Delta-aminolevulinic acid dehydratase
||||----|||--||-||||||----||||||||||||----|||||-||||||||||||||||||  1 [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
-|----|||||-|-----|-||--------||||||||----||||||||||||||----------  1 [L] COG0116 Predicted N6-adenine-specific DNA methylase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0118 Glutamine amidotransferase
||||||||||||||||--||-|||||----||||||------||||||||||||||---|||||--  1 [G] COG0120 Ribose 5-phosphate isomerase
||--|-||--||-|----||-------||-------------|||||-||||-|||---||||---  1 [R] COG0121 Predicted glutamine amidotransferase
||||--|||||||||||-||-|------------|-||----------||---|||---|||||--  1 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0124 Histidyl-tRNA synthetase
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [F] COG0125 Thymidylate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0126 3-phosphoglycerate kinase
||||||||||||||||||||||||||||||||||||||----|||||-||||||||--||||||--  1 [F] COG0127 Xanthosine triphosphate pyrophosphatase
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase
|||----||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase
||||||||||||||||||||||||||||||||||||||||--||||||||||||||--||||||||  1 [J] COG0130 Pseudouridine synthase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0131 Imidazoleglycerol-phosphate dehydratase
-|-----------|--|-|||--|--|||||---|-||----||||||||||||||||||-|||--  1 [H] COG0132 Dethiobiotin synthetase
||||---|||---||-|||||||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0133 Tryptophan synthase beta chain
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0134 Indole-3-glycerol phosphate synthase
||||||-||||||||-||||-||---|---||-|||||----||||||||||||||||||||||--  1 [E] COG0135 Phosphoribosylanthranilate isomerase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0136 Aspartate-semialdehyde dehydrogenase
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0137 Argininosuccinate synthase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0139 Phosphoribosyl-AMP cyclohydrolase
||||-----|||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0141 Histidinol dehydrogenase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [H] COG0142 Geranylgeranyl pyrophosphate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0143 Methionyl-tRNA synthetase
-|-|--||||||||||-|||||||--|||-||||||||----|||||-||||||||--||||||--  1 [J] COG0144 tRNA and rRNA cytosine-C5-methylases
-||--|--|||||||-|-||-------|-------|-|------------------||-|||||--  1 [EQ] COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit
-||--|---||||||-|-||-------|----------------------------||-|||||--  1 [EQ] COG0146 N-methylhydantoinase B/acetone carboxylase, alpha subunit
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0149 Triosephosphate isomerase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0150 Phosphoribosylaminoimidazole (AIR) synthetase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||||||||||--  1 [F] COG0151 Phosphoribosylamine-glycine ligase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||||  1 [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
||||----|||||||-||||||||||||||||||||||||||---|---|---|||||||||||||  1 [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases
-|--||||-----||||-||||||---|||----|-||----|||||-||||||||||||||||||  1 [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes
||||--||||||-|--|||||-----|||||-||-|||----|||||-||||||||||-||-||--  1 [H] COG0157 Nicotinate-nucleotide pyrophosphorylase
||||||-||||||||-||||-||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0159 Tryptophan synthase alpha chain
-|-----------||-|---||-|--|||||---|-||----||||||||||||||||||||||--  1 [H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0162 Tyrosyl-tRNA synthetase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase
||||||||||||||||||||||||-|||||||||||||----|||||-||||||||||||||||||  1 [L] COG0164 Ribonuclease HII
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0165 Argininosuccinate lyase
-|-|||----||||||||||||||||||||||||||||-|||||||||||||||||||||||||--  1 [G] COG0166 Glucose-6-phosphate isomerase
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0167 Dihydroorotate dehydrogenase
||||--||||--|||-||||||--||------||||||-||||||||-||||-||---||||----  1 [P] COG0168 Trk-type K+ transport systems, membrane components
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0169 Shikimate 5-dehydrogenase
|||-|||||||--||||-||----||--------------------------------------||  1 [I] COG0170 Dolichol kinase
|||||||||||||||-||||||--||||||||||||||||||||||||||--||||||||||||--  1 [H] COG0171 NAD synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0172 Seryl-tRNA synthetase
|||||||||||||||-||||-|----||||-|||||||----|||||-||||||||||||||||||  1 [E] COG0174 Glutamine synthetase
-|--||-------||-||||-|||--|||||-||||||----||||||||||-|||||||||||--  1 [G] COG0176 Transaldolase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [L] COG0177 Predicted EndoIII-related endonuclease
|||||||||||||||---||-|----||||----||||----|||||-||-|-|||--||||||--  1 [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0180 Tryptophanyl-tRNA synthetase
||||||--|||||||-|-||||||--|||||---||||----||||||||-|||||||||||||||  1 [H] COG0181 Porphobilinogen deaminase
|||-|||||||||||-|||||---------------|------------|--|-------|-|---  1 [J] COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
||||||||||||||||--|-||---||||||||-||||----|||||-|||----|||-|||||||  1 [I] COG0183 Acetyl-CoA acetyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0184 Ribosomal protein S15P/S13E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0185 Ribosomal protein S19
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0186 Ribosomal protein S17
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0195 Transcription elongation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0197 Ribosomal protein L16/L10E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0198 Ribosomal protein L24
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0199 Ribosomal protein S14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0200 Ribosomal protein L15
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0201 Preprotein translocase subunit SecY
||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit
|||-----||---|||----||----||||||||||||-|||||||||||||||||---|||||--  1 [F] COG0207 Thymidylate synthase
-||---|||--------|---|-----||-||-||||||||||||-|-|------|---||-|---  1 [F] COG0213 Thymidine phosphorylase
|||||||||||||||--|--||----|||||--|||||------------||--------------  1 [H] COG0214 Pyridoxine biosynthesis enzyme
-|||--||||---|--||--|---------||||||||||||||||||||||||||||||||||||  1 [R] COG0218 Predicted GTPase
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG0226 ABC-type phosphate transport system, periplasmic component
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)
||||-||||||-|||-||-||------||||-||-|||-||-|||||-|||||--|||--||||||  1 [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  1 [H] COG0237 Dephospho-CoA kinase
-|||--||-|---||-||||-|----|||-|--|||||----|||||-||||||||||||||||--  1 [D] COG0239 Integral membrane protein possibly involved in chromosome condensation
-|--||-------|||--|-|------||-|-----------|||||||||||||||||---||--  1 [E] COG0241 Histidinol phosphatase and related phosphatases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0244 Ribosomal protein L10
||||||--|||||---|-||||----||||-|----||----|||||-||||-||||||||||---  1 [C] COG0247 Fe-S oxidoreductase
|||||||||||||-|-||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0250 Transcription antiterminator
|||||||||||||||-----||----||||||||||||----|||||-|||-||||||||-|----  1 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D
||------||------|||||-||--|||||---||||----||||||||||||||||||||||||  1 [E] COG0253 Diaminopimelate epimerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0255 Ribosomal protein L29
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0256 Ribosomal protein L18
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI)
|||---|||||||-----------------|-|||-|--||-|||-|-|-||--------------  1 [G] COG0269 3-hexulose-6-phosphate synthase and related proteins
-|--||----------|-|-|------||-|-----------||||||||||-||-|||---|---  1 [G] COG0279 Phosphoheptose isomerase
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0284 Orotidine-5'-phosphate decarboxylase
||||||--|||||||-||||-|----||||||-|||||----|||||-||||||||||||||||--  1 [E] COG0287 Prephenate dehydrogenase
|||-----||------||||--||--|||-||-|||||----||||||||||||||||||||||||  1 [E] COG0289 Dihydrodipicolinate reductase
|||||||||||||||-||||||||--||||||||||||----|||||-||||||||||||||||-|  1 [H] COG0294 Dihydropteroate synthase and related enzymes
-|----||--||--|-||||||||------||-|--||----|||||-||||---|---||-|---  1 [G] COG0297 Glycogen synthase
|||---||||--------||----------|-----------|||-|---|-----|||-------  1 [O] COG0298 Hydrogenase maturation factor
|||||||||||||----|------|-----|||||||||||||||||-||||--------------  1 [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase
||||||||||||-|---|-|-|||--|||||---||||----||||||||||-||||||||-|---  1 [P] COG0306 Phosphate/sulphate permeases
|||||||||||||---|-||----------|-----------|||-|---------|||-------  1 [O] COG0309 Hydrogenase maturation factor
|||||||||||||||--|---|----|||||--|||||------------||--------------  1 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis
|||||||||-|||---|-||-|----|||-----||||----|||||-||||---|||||||||--  1 [H] COG0314 Molybdopterin converting factor, large subunit
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [H] COG0315 Molybdenum cofactor biosynthesis enzyme
||||--||||---|||---|||||||||-|||||||||||--||||||||||-||||||-------  1 [S] COG0327 Uncharacterized conserved protein
|||||||||||||---|||||-||--||||||||||||----||||||||||||||||||||||||  1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase
|||||||||||||||-||||||--||||||||||---|-|--||||||||||||||||||||||||  1 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs
-|--|||-----------|||---|-----|----|-|----|||||-|-||||--||-------|  1 [L] COG0338 Site-specific DNA methylase
||||--|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||||  1 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0341 Preprotein translocase subunit SecF
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0342 Preprotein translocase subunit SecD
|||||||||||||-||||||||||-||---||||||||----||||||||||||||||||||||||  1 [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase
||||||||||||||--||-||-|||-||||||-|||||-|--|||||-||||||||||||||||-|  1 [L] COG0350 Methylated DNA-protein cysteine methyltransferase
|||||||||||||||-||-|||--|-||||||||||||----|||||-||||||||||||||||--  1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0358 DNA primase (bacterial type)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0361 Translation initiation factor 1 (IF-1)
|||||||||||||-----||||----|||-|----|-|----|||-|-||-----|---||||---  1 [H] COG0368 Cobalamin-5-phosphate synthase
|||---|||||-----||||-|--------||--||------|||||-||--|--||||----|--  1 [P] COG0370 Fe2+ transport system protein B
|||||||||||||-|--|||----------||||-|||----|||||-------------|-----  1 [C] COG0371 Glycerol dehydrogenase and related enzymes
||||||--|||||---|-||||||--|||||---||||----|||||-||-||||||||-------  1 [H] COG0373 Glutamyl-tRNA reductase
|||---||||------|-||-|--------------------|||-|---------|||-------  1 [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)
||||--||||||----|||||-----|||||----|||----|||||-||--||||||-||-||--  1 [H] COG0379 Quinolinate synthase
||-|--||---------|||-|--------||-||||-----|||||-||-|-|||--|-----||  1 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase
|||||||||||||||-|-||-|||--|||||------|----|||||-||-|||||||||||||||  1 [H] COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases
-||-------------||||-------||-----|-|-----|||-|--------|----------  1 [R] COG0390 ABC-type uncharacterized transport system, permease component
||||----||---|--||||-|----||||||||||||----|||||-|--|--------------  1 [S] COG0391 Uncharacterized conserved protein
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
||-----|-||-----||||----|-|||-|--|--|-----|||||-||-|-||||||-||||--  1 [M] COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0409 Hydrogenase maturation factor
-|------|-|||----|||||----|------|---|----|||||--|-----|--|||||---  1 [E] COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
-|------|-|||----|||||-----------|--------|||||--|-----|--|||||---  1 [E] COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
||||||||||||||||||||||--||----||--|||-----|||||-||----------------  1 [L] COG0419 ATPase involved in DNA repair
||||||||||||||||||||||--||||||||--||||----|||||-||----------|-----  1 [L] COG0420 DNA repair exonuclease
-|--|||||||||||-||---|----|---|--|--||----||||||-|--||||||----|---  1 [E] COG0421 Spermidine synthase
||||---|||||----||||||----|||||-----||----|||||-||--||||--|||-||--  1 [H] COG0422 Thiamine biosynthesis protein ThiC
||||||||||||||||-----|--|||||||---|---||||------------------------  1 [J] COG0423 Glycyl-tRNA synthetase (class II)
||||--||--||||||||-|-|---||||------|------|||-|--|---|||--|-|-----  1 [P] COG0428 Predicted divalent heavy-metal cations transporter
||||--|||||||||||--|----------------------|||-|--|-----|----------  1 [A] COG0430 RNA 3'-terminal phosphate cyclase
|||---|||||||-|-||||-|-----||-|-----||----|||-|-||---------||-----  1 [S] COG0432 Uncharacterized conserved protein
-|-|--|||||-|-----||----------------------|---|------------|--|---  1 [R] COG0434 Predicted TIM-barrel enzyme
|||-----|--|-||-|-||-||||--||-||||||||----|||||-||||||||||||||||--  1 [I] COG0439 Biotin carboxylase
|||---||||--|||-||||-|----||||||-|||||----||||||||||-|||--||||||--  1 [E] COG0440 Acetolactate synthase, small (regulatory) subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0441 Threonyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0442 Prolyl-tRNA synthetase
|||||||||||||||-||||||--|||||-||||||-|-||||||||-||-|---|---|||||--  1 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases
|||-|||||-|||||||||||||||--|||-||-||||----||||||||-||--|||||||||||  1 [O] COG0450 Peroxiredoxin
|||||||||||||||-||||||---|||||||||||||----|||||-||||||||||||||||--  1 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase
|||||||||-||||||||||||||--|||||||||||||---|||||-||||||||||||||||-|  1 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
||||||||||||||||||||||----|||||||||||||---|||||-||||||||--||||||--  1 [R] COG0456 Acetyltransferases
||||||||||||||||||||||||||||||||||||||--||||||||||||||||||||||||||  1 [O] COG0459 Chaperonin GroEL (HSP60 family)
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0460 Homoserine dehydrogenase
|||||||||||||||-||||||-|--||||||||||||----||||||||||||||||||||||--  1 [F] COG0461 Orotate phosphoribosyltransferase
|||||||||||||||-||||||--||||||||||||||||||||||||||||||||||||||||-|  1 [FE] COG0462 Phosphoribosylpyrophosphate synthetase
||||||||||||||||--||-|----||||------||-----------|-----|--|||-|---  1 [O] COG0464 ATPases of the AAA+ class
||||||||||||||--||||---------------------------------------||-|---  1 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction
-|||||||--||||||-|||||||-|||||||||||||||||||||||||||||||--||||||--  1 [G] COG0469 Pyruvate kinase
||----||-|||-||-||||||||||||||||||||||----|||||||||||||||||||||-||  1 [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
|||-|--------||||-|||-----||||||||-||||||||||||--|----------|||---  1 [P] COG0474 Cation transport ATPase
|||-|||||-|||||-|-||-|---|-|||||--||||----|||||-|||-||||||||||||||  1 [P] COG0475 Kef-type K+ transport systems, membrane components
-|||--||||||||||--------------------------------------------------  1 [T] COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||||||||||||  1 [C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0480 Translation elongation factors (GTPases)
||||||||||||||||||||||----|||||--|||||----|||||-||||||||||||||||||  1 [D] COG0489 ATPases involved in chromosome partitioning
||||||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0492 Thioredoxin reductase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0495 Leucyl-tRNA synthetase
||||----|||-||--||||-||||-----------------|||||-||||||||||||||||--  1 [R] COG0496 Predicted acid phosphatase
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0498 Threonine synthase
|||||||||||||||-||||------||||-------------------|--|--|---|||||--  1 [H] COG0499 S-adenosylhomocysteine hydrolase
|||||||||||||||||-||||----|||||-||-|||----||||||||||||||||||||||--  1 [O] COG0501 Zn-dependent protease with chaperone function
||||--||-||||||--|||||--|||||-||||||||||||||||||||||-||||||||||---  1 [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
||||||||||||||||||||-|||||||||||||||||||--||||||||||||||||||||||||  1 [F] COG0504 CTP synthase (UTP-ammonia lyase)
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  1 [EF] COG0505 Carbamoylphosphate synthase small subunit
-|-----------||----|-|||-|-||-||||||||-|--|||||||||||||---|||||---  1 [L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member
|||---|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||--  1 [I] COG0511 Biotin carboxyl carrier protein
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II
|||-||--|--|-||||-||||--|-||||||||||||||||||||||||||||||||-|||||||  1 [LKJ] COG0513 Superfamily II DNA and RNA helicases
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0518 GMP synthase - Glutamine amidotransferase domain
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0519 GMP synthase, PP-ATPase domain/subunit
|||||||||||||---|--|-|----|||||---||||----|||||-||||---|||||||||--  1 [H] COG0521 Molybdopterin biosynthesis enzymes
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0522 Ribosomal protein S4 and related proteins
|||||||||||||||--|||-|----||||||||||||----|||||-|||||--|---|||||--  1 [G] COG0524 Sugar kinases, ribokinase family
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0525 Valyl-tRNA synthetase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0527 Aspartokinases
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0528 Uridylate kinase
||||||||||||-||-|||-----||-----------|----|||||-|--|--------|-----  1 [P] COG0530 Ca2+/Na+ antiporter
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0533 Metal-dependent proteases with possible chaperone activity
||||--|||---|||-|||-||--|||||-|||||||||||||||||-||||||||||||||||--  1 [V] COG0534 Na+-driven multidrug efflux pump
|||||||||-|||||||-||||||-|||||||||||||||||||||||||||||||||||||||||  1 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
|||||||||||||||-||||||----||||||||||||----||||||||--||||||||||||--  1 [F] COG0540 Aspartate carbamoyltransferase, catalytic chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0541 Signal recognition particle GTPase
|||-||||||-|-||-||--|---|-|||-||-|-|||----|||||-||---|||---|----||  1 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0547 Anthranilate phosphoribosyltransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||-|  1 [E] COG0548 Acetylglutamate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0550 Topoisomerase IA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0552 Signal recognition particle GTPase
||||||||||||------||-|-----||-|------|----|||||-||||||||---|||||--  1 [O] COG0555 ABC-type sulfate transport system, permease component
-|------|-|||----|||||----|------|---|----|||||--|-----|--|||||---  1 [E] COG0559 Branched-chain amino acid ABC-type transport system, permease components
|||||||||||-|||-----|--|--||||||----------|||||-||||||||||||||||--  1 [E] COG0560 Phosphoserine phosphatase
||||||--||-||-----||-|--------------------|||||-||||||||---|||||-|  1 [J] COG0565 rRNA methylase
||||--|||||-|---||||||--||-||---||||||-||||||||-||||-||---||||----  1 [P] COG0569 K+ transport systems, NAD-binding component
||||---||||||---||||-|---||||||||||||||-|||||||-|-|||--|--||||||--  1 [P] COG0573 ABC-type phosphate transport system, permease component
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [I] COG0575 CDP-diglyceride synthetase
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG0581 ABC-type phosphate transport system, permease component
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
||||--||-|-------|||||----||||||||||||||||--------------||||||||||  1 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily
-||---|-|-||-||-||||||----|||||||||||-----|||||-|||||--|||||||||-|  1 [P] COG0598 Mg2+ and Co2+ transporters
-||-----||-------|||||||--|---|--||-||----||||---|||---|---|||||--  1 [P] COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
||||||||||||----|-|||---------||||||||----|||||-||||||||||||||||||  1 [O] COG0602 Organic radical activating enzymes
|||||||||||||---|-||----------|---|-||----|||||-||||||||||||||||||  1 [R] COG0603 Predicted PP-loop superfamily ATPase
|||||||||||||---|-||------||||------||----||||||||||||||--|----|--  1 [H] COG0611 Thiamine monophosphate kinase
|||||||||||||||||--------------|--|||----------------------------|  1 [MI] COG0615 Cytidylyltransferase
|||||||||||||||-||-----|--||||-|-|||||----||||||||||||||--||--||--  1 [E] COG0620 Methionine synthase II (cobalamin-independent)
|||||||||||||---||||||-||-|||||---|-||----||||||||||||||||||||||||  1 [J] COG0621 2-methylthioadenine synthetase
||||--|||-------||||||--|||||-||||||||----||||||||||||||||||||||||  1 [R] COG0628 Predicted permease
||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K
-|||||||||||||||-|||||--------||-|-|||----||||||||||||||--|||-||--  1 [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
|||-----|--|-----|||----------|-----------|||||---||--------|-----  1 [R] COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)
||||||||--||||||||----||---||||---|||||||||||||||-----------------  1 [L] COG0648 Endonuclease IV
||||-||||-|||----|||-|----|||-----||||----|||-|-||---------|||--||  1 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit
|||---||||------|||||------||-------||----|||||-||--||||||-|||||--  1 [G] COG0662 Mannose-6-phosphate isomerase
|||-||||-|-|----|-||-|----|||-|-----||----|||-|-||--||||--||||||||  1 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily
||----||--|------|------------|---|-------|||||-||-||--|---||-|---  1 [M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase
||-------|---||-|||||-----|---||--||||----||||--||-||--|--||||||||  1 [R] COG0679 Predicted permeases
||||||||||||||||||||||||||||||||||||||-|--||||||||||||||||||||||||  1 [U] COG0681 Signal peptidase I
-|-|----|-|||----|||||----|------|---|----|||||--|-----|--|||||---  1 [E] COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
|||-----||---|-------|----||||-------|----|||||-||||---|---||-|---  1 [H] COG0684 Demethylmenaquinone methyltransferase
||||----||---||-----||||---||||-----||----|||||-|||||||||||||||-||  1 [I] COG0688 Phosphatidylserine decarboxylase
-||||||||||||||-|-||||--||-||-|--|||||-||||||||-||-||--|--||||||--  1 [R] COG0693 Putative intracellular protease/amidase
|||-----||------||||-------||-|-||-|||----|||-------------|-------  1 [R] COG0701 Predicted permeases
-||||-|||||||||-||||-|--|-||||||||||||----|||||-|||||--|--||||||--  1 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
-|-------|||----|-------------------------|||||--|||------|-|-----  1 [E] COG0709 Selenophosphate synthase
||||||-|||||-||-|-----||-------||||||-----|||-|------||-----------  1 [E] COG0710 3-dehydroquinate dehydratase
-||-----||---||--|||||||--|---|--||-||----||||--||||---|---|||||--  1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
|||-----||---||---|||---|-----||||-||-----|||||||||||--||||-------  1 [C] COG0716 Flavodoxins
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
||||||||||||----||||----------|---|-||----|||||-||||||||||||||||||  1 [H] COG0720 6-pyruvoyl-tetrahydropterin synthase
||||----||-||---||||||||||||||||||||||--||-------|---|||||||||||||  1 [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [P] COG0725 ABC-type molybdate transport system, periplasmic component
|||||||||||||---||||||----|--|||--||||----|||||-||||||||||||||||--  1 [R] COG0730 Predicted permeases
-|||--|||-------|---|-|||-|------|||||----------|-||-||-|||-------  1 [R] COG0733 Na+-dependent transporters of the SNF family
|||||||||||||---|-||-|----|||-----||||----|||||-||||--||||||||||--  1 [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A
|||||||||||||---||||||||||||||||||||||----|||||-||||||||||||||||||  1 [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1
|||------|------||||||||||||||||||||||----||||||||||||||||||||||||  1 [M] COG0770 UDP-N-acetylmuramyl pentapeptide synthase
|||||--||||||---||||||----||||||||||||----|||||-||||||||||||||||--  1 [C] COG0778 Nitroreductase
|||---|||||||---|---|-||------|---|||-----|||||-||||||||||||||||||  1 [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation
-|-------------------------|||||||||||------------|-----||-|--|---  1 [L] COG0827 Adenine-specific DNA methylase
||||||--|---------------------------------------------------------  1 [F] COG0856 Orotate phosphoribosyltransferase homologs
|||-----||-----------|---|----|----|||----|||--------------||||---  1 [F] COG1001 Adenine deaminase
||||--||---------|||-|----|-------||||----------||---------|||--||  1 [P] COG1006 Multisubunit Na+/H+ antiporter, MnhC subunit
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG1010 Precorrin-3B methylase
||||--||-|||-|||-|-|-|--|||||-||||||||----|||||-||-|-|||---|||||--  1 [R] COG1011 Predicted hydrolase (HAD superfamily)
||||||---||||||-|-||||----|||||||||||||---|||||-||-|-|||||||||||-|  1 [C] COG1012 NAD-dependent aldehyde dehydrogenases
|||||||||||--||---------------------------------------------------  1 [R] COG1019 Predicted nucleotidyltransferase
|||-----||--------------------------------------------------------  1 [C] COG1029 Formylmethanofuran dehydrogenase subunit B
-|||--|||||-|----|------------------------------------------------  1 [C] COG1031 Uncharacterized Fe-S oxidoreductase
-|||--||||-------|------||-----------|-----------|--------|-------  1 [R] COG1033 Predicted exporters of the RND superfamily
|||||||||||||||---------------------------------------------------  1 [L] COG1041 Predicted DNA modification methylase
-|||||||||||-------|----------------------|||||-||---||-----|-|---  1 [C] COG1042 Acyl-CoA synthetase (NDP forming)
|||---|||||||---|-||-|----||||||-|-|||-------|--||-----|---|||||-|  1 [F] COG1051 ADP-ribose pyrophosphatase
||-|||--|||||||-||||||||--||||||--||||----|||||-||||||||||||||||||  1 [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
|||||||||-|||-----|--|-----||--|----------|||||---||---|----------  1 [H] COG1056 Nicotinamide mononucleotide adenylyltransferase
-|--||--|--|----||--|---------------------------------------------  1 [L] COG1059 Thermostable 8-oxoguanine DNA glycosylase
||||||||||-------|------|-----|-----||----|||||-||||--------------  1 [O] COG1067 Predicted ATP-dependent protease
|||||||||||||--|||--|----------||||||||-||------------------------  1 [R] COG1078 HD superfamily phosphohydrolases
||||||||||||||||--------------------------------------------------  1 [R] COG1084 Predicted GTPase
-|---------------|--|---|-|---|--||-||----------||-||||||||-||||||  1 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases
||||||||||||||||--------------------------------------------------  1 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)
||||||||||||||||--------------------------------------------------  1 [R] COG1094 Predicted RNA-binding protein (contains KH domains)
||||||||||||||||--------------------------------------------------  1 [K] COG1095 DNA-directed RNA polymerase, subunit E'
|||||||||||||||||-||-|----------------------------------------|---  1 [R] COG1100 GTPase SAR1 and related small G proteins
|||||||||||||-----------||----------------------------------------  1 [F] COG1102 Cytidylate kinase
|||-----||--------------------------------------------------------  1 [R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes
||||--||||--------------------------------------------------------  1 [L] COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain
||||||||||---||---------------------------------------------------  1 [L] COG1111 ERCC4-like helicases
|||||-||||-|-||||||-|------||||---|---|||||||-|--|--|---|--------|  1 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits
-||-||--||||-----|||||||--|---|--||-||----||||---||||--|---|||||--  1 [P] COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG1117 ABC-type phosphate transport system, ATPase component
|||||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)
|||-||||||||----||--------------------------------------||--------  1 [C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit
|||-----||-|----||------------------------------------------------  1 [C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins
|||-----||--------------------------------------------------------  1 [C] COG1153 Formylmethanofuran dehydrogenase subunit D
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B
-||---||-|||||||-||||----|----||||||||||||------|----||-----------  1 [R] COG1161 Predicted GTPases
||||||||||||||||--------------------------------------------------  1 [R] COG1163 Predicted GTPase
||||----||---||-----|-||-|-||||-----||-----------|--|||||||||||-||  1 [I] COG1183 Phosphatidylserine synthase
-||||||||-|-|||--|------------------------------------------------  1 [J] COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
||-|-|||-|||----|-||-||||||||||----|||--|||||||-||--||||||||||||||  1 [D] COG1192 ATPases involved in chromosome partitioning
-||||||||----|||||||||--||||||||||||||||||-------|--|||----|||||--  1 [D] COG1196 Chromosome segregation ATPases
||||||||--|||||||-|||-----|||-||||||||----|||||-||||||||-------|--  1 [KL] COG1199 Rad3-related DNA helicases
|||||||||||||------|------|||-------------|||----|-----|---|||||--  1 [R] COG1201 Lhr-like helicases
||||--||-|--------------------------------------------------------  1 [R] COG1202 Superfamily II helicase, archaea-specific
|||||||||||||||||-||-|----|||||-----||-------||--|--||||--||||||--  1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)
|||----|---|----|--||----|||||||||||||--|||||||-||||||||||||||||--  1 [M] COG1210 UDP-glucose pyrophosphorylase
||||--||||-|||||--------------------------------------------------  1 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit
|||-----||--------------------------------------------------------  1 [R] COG1223 Predicted ATPase (AAA+ superfamily)
-|------|----|||-|--||--------|||||||-----------|-----------------  1 [C] COG1227 Inorganic pyrophosphatase/exopolyphosphatase
|||-----||--------------------------------------------------------  1 [C] COG1229 Formylmethanofuran dehydrogenase subunit A
||||-------||-----||-|----|||-----||-|-----------------|------||--  1 [Q] COG1233 Phytoene dehydrogenase and related proteins
||||||||||||||||-|||-|||||||||||||||||----|||-|----|---|------||--  1 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
||||||||||----|-|-|||-||||----||||||||----||||---|-----|---|||||||  1 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
-||||||-|-||||||--||-|--------------------------||-----|---||-||--  1 [J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing
||||||--||--------||-|----|||--------------------|-----|----------  1 [H] COG1239 Mg-chelatase subunit ChlI
||||||---|--------||------|||--------------------|-----|----------  1 [H] COG1240 Mg-chelatase subunit ChlD
-|-------|------||--|---------|||-||||----|||||-|-----------------  1 [R] COG1242 Predicted Fe-S oxidoreductase
||||||||||||-|||-|--|---------|-----------------------------------  1 [KB] COG1243 Histone acetyltransferase
||||||||||--------------------|-----------------------------------  1 [R] COG1244 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
||||||--|||||||-||||||||--||||-|||||||-|||||||||||||||||---|||||||  1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
||-|--|||---------------------------------------------------------  1 [S] COG1255 Uncharacterized protein conserved in archaea
||||||||||||||||---------|-----|||||------------|-----------------  1 [I] COG1257 Hydroxymethylglutaryl-CoA reductase
|||||||||||||--|--------------------------------------------------  1 [J] COG1258 Predicted pseudouridylate synthase
|||---||-||-|---|---|-----------|--|||----|||||-||||-||||||-----||  1 [I] COG1267 Phosphatidylglycerophosphatase A and related proteins
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I
|||||||||||||-----||||-----||-|----|-|--------|-||-----|---||||---  1 [H] COG1270 Cobalamin biosynthesis protein CobD/CbiB
|||||||||-||-||-------------------------------------------|-------  1 [R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation
||||||||||||||||-|||||---|----||||||||------------------|||-------  1 [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP
||||||||||-||-----------------------------------------------------  1 [S] COG1303 Uncharacterized protein conserved in archaea
|||||||||||||||---||-|--||||||-||||||-----|||||-||||-||----|||||||  1 [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
|||||||||||-||||--------------------------------------------------  1 [K] COG1308 Transcription factor homologous to NACalpha-BTF3
||||||||||---|||--------------------------------------------------  1 [L] COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
|||---|||||-|---||------------|-----------------------------------  1 [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins
-|----|||||-|---||------------------------------------------------  1 [K] COG1318 Predicted transcriptional regulators
||||--||---------|---|----|-------||||----------||---------|||--||  1 [P] COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit
|||||||||||||----|---||||-||||||||||||----|||-|-----|---------|---  1 [K] COG1321 Mn-dependent transcriptional regulator
||-------|-------|--|---------||||||||-|--------------------------  1 [R] COG1323 Predicted nucleotidyltransferase
||||--|||||||-----------------------------------------------------  1 [J] COG1325 Predicted exosome subunit
||||--||||--------------------------------------------------------  1 [R] COG1326 Uncharacterized archaeal Zn-finger protein
|||--||----------|---------||-------------------------------------  1 [L] COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||--||--|||-----|-|-------||-------------------------------------  1 [L] COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||||||||||||-----------------------------------------------------  1 [KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon
-|----|||||||||---------------------------------------------------  1 [R] COG1341 Predicted GTPase or GTP-binding protein
|||---|||---------------------|-----------------|-----------------  1 [R] COG1342 Predicted DNA-binding proteins
|||--|--||||-----|-||------||---|----|----------------------------  1 [L] COG1343 Uncharacterized protein predicted to be involved in DNA repair
|||------|--------|||---------|-----------------------------|-|---  1 [P] COG1348 Nitrogenase subunit NifH (ATPase)
|||--||-||||----||---------||--------|----------------------------  1 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs)
-||||||||-------||||||--|-||||||||||||||||-------|--||||---|||||--  1 [S] COG1354 Uncharacterized conserved protein
|||-|||||||||||-||--------------------------------------------|---  1 [R] COG1355 Predicted dioxygenase
||-|--||----------------------------------------------------------  1 [S] COG1356 Uncharacterized protein conserved in archaea
||||||||||||||||-|--|---------||||||||----------------------------  1 [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a)
||||--|||||-|----|-|||--------||||||||||--|||-|--|----------|-----  1 [G] COG1363 Cellulase M and related proteins
|||-----||---||-||||-|----||||||--||||-----------|---|||---|||||--  1 [E] COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase)
||----||-|--------------------------------------------------------  1 [R] COG1365 Predicted ATPase (PP-loop superfamily)
||||--||||-||||---------------------------------------------------  1 [J] COG1369 RNase P/RNase MRP subunit POP5
|||||||||||||-----------------------------------------------------  1 [O] COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit
|||||||||||||---||---------||-------------------------------------  1 [S] COG1371 Uncharacterized conserved protein
-|----||||--||||--------------------------------------------------  1 [J] COG1374 Protein involved in ribosomal biogenesis, contains PUA domain
|||||||||||||--------|--------------|-----------------------------  1 [K] COG1378 Predicted transcriptional regulators
|||||||||||||||---------------------------------------------------  1 [O] COG1382 Prefoldin, chaperonin cofactor
||||||||||||||||--------------------------------------------------  1 [J] COG1383 Ribosomal protein S17E
||||||||||--|-----------||-----------------------------------|||||  1 [J] COG1384 Lysyl-tRNA synthetase (class I)
|||-||||||---||-||--||-----||-||--||||----|||||-|-----------|-----  1 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family
||||--|||||||-----------------------------------------------------  1 [L] COG1389 DNA topoisomerase VI, subunit B
|||||||||||-||||----||||||----------------------------------------  1 [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E
|||---|||--|-----|---|||------|---|||-----------||||---|---||-|---  1 [P] COG1392 Phosphate transport regulator (distant homolog of PhoU)
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D
|||||||||||||-----------------------------------------------------  1 [K] COG1395 Predicted transcriptional regulator
-||-----|-------|--|-|--------|--|--------|||-|---------------|---  1 [O] COG1397 ADP-ribosylglycohydrolase
||||||||||||||||--------------------------------------------------  1 [U] COG1400 Signal recognition particle 19 kDa protein
||-|-----||||----|||-------||------|-|---------------------|||||--  1 [R] COG1402 Uncharacterized protein, putative amidase
|||||||||||||----------------------------------------------|||||--  1 [R] COG1407 Predicted ICC-like phosphoesterases
|||-----||--------------------------------------------------------  1 [R] COG1411 Uncharacterized protein related to proFAR isomerase (HisA)
||||||||||||||||--------------------------------------------------  1 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
||------||--------------------------------------------------------  1 [S] COG1417 Uncharacterized conserved protein
||||||||||------||--||--||----|||||||||-|||||-|---------|||||-----  1 [R] COG1418 Predicted HD superfamily hydrolase
||---||--|-------|------------------------------------------------  1 [L] COG1421 Uncharacterized protein predicted to be involved in DNA repair
||||||||||--------------------------------------------------------  1 [S] COG1422 Predicted membrane protein
|||---||||--|---|-------------------------------------------------  1 [L] COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III
-|--------------|-----------------|-|-----------------------------  1 [H] COG1424 Pimeloyl-CoA synthetase
||-|--||-||------|||----||--------------------------|--|---|||||--  1 [S] COG1430 Uncharacterized conserved protein
-|------||------|-------------------------------------------------  1 [J] COG1431 Uncharacterized protein containing piwi/argonaute domain
||||--||||------|-||-|--|-|---------------------||----|-||||||||--  1 [S] COG1432 Uncharacterized conserved protein
||||||||||||||||----||--|--------|--------------------------------  1 [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F
||||--|||||||------------|----|--------------|---------|----------  1 [F] COG1437 Adenylate cyclase, class 2 (thermophilic)
||||||||||||||||--------------------------------------------------  1 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
-||-||||--||----|-||----|-----------------------------------------  1 [G] COG1449 Alpha-amylase/alpha-mannosidase
|||-----||--------------------------------------------------------  1 [C] COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)
|||---||||--|---|-------------------------------------------------  1 [R] COG1458 Predicted DNA-binding protein containing PIN domain
|||||||||||||-----------------------------------------------------  1 [S] COG1460 DNA-directed RNA polymerase, subunit F
||||----||------|-------------------------------------------------  1 [E] COG1465 Predicted alternative 3-dehydroquinate synthase
||||||||||||||||--------------------------------------------------  1 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit
|||---|||-|||---||-||-----------|----|----------------------------  1 [L] COG1468 RecB family exonuclease
||||||||||--|----|----------------|-||-----------|--||||----------  1 [S] COG1469 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1471 Ribosomal protein S4E
||-|--|||-|||---|--|-|||||||||||||||||----|||||-||--||||||||||||||  1 [K] COG1475 Predicted transcriptional regulators
||||---||----------|-|--------||||||||-----------|-------------|--  1 [K] COG1476 Predicted transcriptional regulators
||||----||------------||---|||--|---------------------------------  1 [S] COG1478 Uncharacterized conserved protein
-|||--|----------|-||-----|---|----|--||---|||--|--|--|-|||-------  1 [S] COG1479 Uncharacterized conserved protein
|||||||||||||-----------------------------------------------------  1 [J] COG1491 Predicted RNA-binding protein
||||||--||--------------------------------------------------------  1 [K] COG1497 Predicted transcriptional regulator
||||||||||||||||--------------------------------------------------  1 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog
||||||||||||||||--------------------------------------------------  1 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay
||||||||||||||||--------------------------------------------------  1 [J] COG1500 Predicted exosome subunit
|||||||||||||||||-------------------------------------------------  1 [J] COG1503 Peptide chain release factor 1 (eRF1)
-||-------------||--||--|-----------||----|||||-|-|||------||-||--  1 [E] COG1509 Lysine 2,3-aminomutase
-|----||--------------------------|-|------------------|---|-|----  1 [K] COG1510 Predicted transcriptional regulators
|||-|||||||||---||-|-|----|---|---|-||----|||||--|-----|---|||||--  1 [J] COG1514 2'-5' RNA ligase
-|---||---||----|-------------------------------------------------  1 [L] COG1517 Uncharacterized protein predicted to be involved in DNA repair
|||-|||-|||||---||-||------||---|--|-|----|||||----|--|---|-------  1 [L] COG1518 Uncharacterized protein predicted to be involved in DNA repair
||-|--||-|---||-|--|------|-------|-|--|||-------|||-||---|||||---  1 [L] COG1525 Micrococcal nuclease (thermonuclease) homologs
|||-||--|-||--------------|||-----||||----|||||-||||---|--||||||--  1 [C] COG1526 Uncharacterized protein required for formate dehydrogenase activity
|||||||||||--|||----||----------||--------------------------------  1 [C] COG1527 Archaeal/vacuolar-type H+-ATPase subunit C
||-----||||||-----------------------------------------------------  1 [S] COG1531 Uncharacterized protein conserved in archaea
||------||--------------------------------------------------------  1 [R] COG1532 Predicted RNA-binding protein
-||-|-|||||||----||-|------||-|-----||-----------|-----|---|||||-|  1 [L] COG1533 DNA repair photolyase
||||--||||-||-------|---------||||||||----|||||-||||||||----------  1 [J] COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
||||||||||||||||--------------------------------------------------  1 [R] COG1537 Predicted RNA-binding proteins
-|-------|------||------------------------------------------------  1 [S] COG1542 Uncharacterized conserved protein
|||||||||||||--------------||----------------------------------|--  1 [R] COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon
|||-----||--------------------------------------------------------  1 [KG] COG1548 Predicted transcriptional regulator/sugar kinase
||||||||||-|------------------------------------------------------  1 [J] COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain
||||||||||||||||--------------------------------------------------  1 [J] COG1552 Ribosomal protein L40E
|||------|-------|------------------------||||||||||--------------  1 [P] COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction
||----|----------|||--------------------------------------------||  1 [P] COG1563 Predicted subunit of the Multisubunit Na+/H+ antiporter
|||--||----------|---------||-------------------------------------  1 [L] COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
-|----|||---------||--------------------------------|-------------  1 [R] COG1569 Predicted nucleic acid-binding protein, contains PIN domain
||||--||||||||||---------|-----|||||------------------------------  1 [I] COG1577 Mevalonate kinase
|||---|||||-----||------------------------------------------------  1 [S] COG1578 Uncharacterized conserved protein
||--|||||||||-----------------------------------------------------  1 [K] COG1581 Archaeal DNA-binding protein
||-|--||-||||----|||||----|||||-----------|||||-||-||------|||||--  1 [OU] COG1585 Membrane protein implicated in regulation of membrane protease activity
-|--|||||-|||---||------------|-----||----||||||-|--|--|----------  1 [E] COG1586 S-adenosylmethionine decarboxylase
||||||--||||-||-|-||||||--|||||---||||----|||||-||-||||||||||||---  1 [H] COG1587 Uroporphyrinogen-III synthase
||||||||||--|-----------------------------------------------------  1 [J] COG1588 RNase P/RNase MRP subunit p29
-|----|||||||||---------------------------------------------------  1 [S] COG1590 Uncharacterized conserved protein
||-|--|||||||-----------------------------------------------------  1 [L] COG1591 Holliday junction resolvase - archaeal type
|||||||||-||||||--------------------------------------------------  1 [K] COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS
||||||||||-|||||--------------------------------------------------  1 [L] COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
||||||||||||||||--------------------------------------------------  1 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain
||||--||||-||||---------------------------------------------------  1 [J] COG1603 RNase P/RNase MRP subunit p30
||||||--|||||||-||--||----||||||||||||----||||||||||||||||||||||--  1 [E] COG1605 Chorismate mutase
|||-----||-------|||----------|-----------------------------------  1 [R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily
|||||||||||||-----------------------------------------------------  1 [R] COG1608 Predicted archaeal kinase
|||---||||--------------------------------------------------------  1 [S] COG1617 Uncharacterized conserved protein
|||-|||||||||---||------------------------------------------------  1 [F] COG1618 Predicted nucleotide kinase
-|||--||||------|-||-|||||----||||||||-|||------------------------  1 [S] COG1624 Uncharacterized conserved protein
|||---||-|--------||-|--------|-----------------------------------  1 [C] COG1625 Fe-S oxidoreductase, related to NifB/MoaA family
||----||-|--------------------------------------------------------  1 [S] COG1627 Uncharacterized protein conserved in archaea
|||||||||||||--------|--------------------------------------------  1 [S] COG1628 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1631 Ribosomal protein L44E
||||||||||||||||--------------------------------------------------  1 [J] COG1632 Ribosomal protein L15E
|||||||||||||-----------------------------------------------------  1 [R] COG1634 Uncharacterized Rossmann fold enzyme
||||--|||||||||--|------------------------------------------------  1 [H] COG1635 Flavoprotein involved in thiazole biosynthesis
||-|--||-||||------|------||||------------------------------------  1 [L] COG1637 Predicted nuclease of the RecB family
|||-----||-------|||------|---|-----------------------------------  1 [S] COG1641 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
-|||--|||||||-----------------------------------------------------  1 [R] COG1645 Uncharacterized Zn-finger containing protein
|||||||||||||---------------------||||----------------------------  1 [R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold
||||||--|||-|||-|---|------||-|---||||----||||||||--|||----|||||--  1 [H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)
-||||||||||||-----------------------------------------------------  1 [S] COG1650 Uncharacterized protein conserved in archaea
|||-|||||-------|---|----|----|||||||||-||------------------------  1 [L] COG1658 Small primase-like proteins (Toprim domain)
|||-----||-|------------------------------------------------------  1 [S] COG1665 Uncharacterized protein conserved in archaea
||------||--------------------------------------------------------  1 [S] COG1667 Uncharacterized protein conserved in archaea
||||--|||-|||----|---|--------||-|||||--------------|----------|--  1 [CP] COG1668 ABC-type Na+ efflux pump, permease component
-|||||-|-----||--|-|||----||||||||||||--|-|||||-||-|-|||||||||||||  1 [J] COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
||||--||||||||||--------------------------------------------------  1 [K] COG1675 Transcription initiation factor IIE, alpha subunit
||||||||||||||||--------------------------------------------------  1 [J] COG1676 tRNA splicing endonuclease
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1679 Uncharacterized conserved protein
||||||-||||||-----------------------------------------------------  1 [EH] COG1685 Archaeal shikimate kinase
|||---|||-|||---||------------------------------------------------  1 [L] COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||-----||-------|||------|---|-----------------------------------  1 [R] COG1691 NCAIR mutase (PurE)-related proteins
|||-----||--------------------------------------------------------  1 [S] COG1693 Uncharacterized protein conserved in archaea
||||--||||||||||--------------------------------------------------  1 [L] COG1697 DNA topoisomerase VI, subunit A
|||-||||||-||-----------------------------------------------------  1 [S] COG1698 Uncharacterized protein conserved in archaea
||||--|||||||-----------------------------------------------------  1 [S] COG1701 Uncharacterized protein conserved in archaea
-||--------------|--|---|-------||-|--||---|||---|-|---|---|||||--  1 [S] COG1704 Uncharacterized conserved protein
||------||--------------------------------------------------------  1 [R] COG1707 ACT domain-containing protein
-||||||||||||-----------------------------------------------------  1 [K] COG1709 Predicted transcriptional regulator
||----||----------------------------------------------------------  1 [S] COG1710 Uncharacterized protein conserved in archaea
|||-----|||------|-------------------------------|-----|----------  1 [R] COG1712 Predicted dinucleotide-utilizing enzyme
||||||||||||||||--------------------------------------------------  1 [J] COG1717 Ribosomal protein L32E
||||||||||||||||-----|-----------------------|---|----------------  1 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control
||||--|||||||----|------------------------|||||-||||-||-------||--  1 [S] COG1720 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1727 Ribosomal protein L18E
|||-----|||||-----------------------------------------------------  1 [H] COG1731 Archaeal riboflavin synthase
||||||||||||||||--------------------------------------------------  1 [J] COG1736 Diphthamide synthase subunit DPH2
|||||||||||||-----------------------------------------------------  1 [J] COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme)
-||---|||-|||-----------------------------------------------------  1 [R] COG1750 Archaeal serine proteases
|||-----|--------|------------------------------------------------  1 [S] COG1751 Uncharacterized conserved protein
-||---|||---------------------------------------------------------  1 [S] COG1753 Uncharacterized conserved protein
-|--||||||||||||--------------------------------------------------  1 [S] COG1756 Uncharacterized conserved protein
||||||||||||||||||||-|--||||||||||||||----|||||-||||||||||||||||||  1 [K] COG1758 DNA-directed RNA polymerase, subunit K/omega
|||---||||||------------------------------------------------------  1 [R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)
||||||||||||||||--------------------------------------------------  1 [K] COG1761 DNA-directed RNA polymerase, subunit L
|||||-|||||||---|-----------------||||----|||||-|-||---|--|||||---  1 [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein
-||-||||-|-||---||---|----|||-|----|-|--|||||||-||---|||---||-||--  1 [O] COG1765 Predicted redox protein, regulator of disulfide bond formation
|||---||||-||-------|-----------|---------|||-|-|||---------------  1 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase
||----||----------------------------------------------------------  1 [S] COG1771 Uncharacterized protein conserved in archaea
-||---||||--------------------------------------------------------  1 [S] COG1772 Uncharacterized protein conserved in archaea
-|------||----------|---------|-----------|||---------------------  1 [E] COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB
|||-|||||||||||---------------------------------------------------  1 [R] COG1779 C4-type Zn-finger protein
|||||||||||||----|------------|-----------|||||||----||-----------  1 [F] COG1781 Aspartate carbamoyltransferase, regulatory subunit
||||--||||--------------------------------------------------------  1 [S] COG1784 Predicted membrane protein
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1786 Uncharacterized conserved protein
||------||--------------------------------------------------------  1 [S] COG1790 Uncharacterized protein conserved in archaea
|||||||||||||||||----------||-------||----------|||--||---|||-||--  1 [L] COG1793 ATP-dependent DNA ligase
|||-----||-----------------------------------|--------------------  1 [S] COG1795 Uncharacterized conserved protein
||||||--||||------||||-----||-|----|-|--------|--|-----|---||||---  1 [H] COG1797 Cobyrinic acid a,c-diamide synthase
||||||||||||||||--------------------------------------------------  1 [J] COG1798 Diphthamide biosynthesis methyltransferase
||-------|----------------|---------|-----------------------------  1 [S] COG1809 Uncharacterized conserved protein
|||||||||||||---|---------------|---------------------------------  1 [E] COG1812 Archaeal S-adenosylmethionine synthetase
||||||||||||||||--------------------------------------------------  1 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1
||--|||||||||||--|---||---|----|-----------------|------------||--  1 [S] COG1814 Uncharacterized membrane protein
|||---||--|-------------------------------------------------------  1 [S] COG1817 Uncharacterized protein conserved in archaea
|||------|---|----|--|-----||||-----|------||||-||------------|---  1 [GC] COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
|||-----||--------------------------------------------------------  1 [R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)
||||||||||||----||||-|----||||-|--||||--------------------|-||||--  1 [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component
||||--|||||||-----------------------------------------------------  1 [R] COG1829 Predicted archaeal kinase (sugar kinase superfamily)
|||||||||||-|-----------------------------------------------------  1 [R] COG1831 Predicted metal-dependent hydrolase (urease superfamily)
||||-|||||||-----|------------------------------------------------  1 [S] COG1833 Uncharacterized conserved protein
|||||||||-|-------||-----------------|----------------------------  1 [S] COG1836 Predicted membrane protein
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain
||||||||||||||||||--||--||||||||||||||----||||||||||||||----||||||  1 [J] COG1841 Ribosomal protein L30/L7E
|||---||-|--------------------------------------------------------  1 [S] COG1844 Uncharacterized protein conserved in archaea
|||||||||||||----|-|||----||||||||||||----|||||-||--||||---|||||--  1 [K] COG1846 Transcriptional regulators
|||||||||||||-----------------------------------------------------  1 [S] COG1849 Uncharacterized protein conserved in archaea
-||---|||---------||----------------|-----------------------|-|---  1 [G] COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit
-|----||--------|-------------------------------------------------  1 [S] COG1851 Uncharacterized conserved protein
|||----||-----------|---------------------------------------------  1 [S] COG1852 Uncharacterized conserved protein
|||||||||||||-----------------------------------------------------  1 [R] COG1855 ATPase (PilT family)
|||---|||-|||---|---|---------------------------------------------  1 [L] COG1857 Uncharacterized protein predicted to be involved in DNA repair
|||||||-|-|-------------------------------------------------------  1 [S] COG1860 Uncharacterized protein conserved in archaea
-|------------------|---|-----|-----|--------------------------|--  1 [M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog
||||--||---------|---|----|-------||||----------||---------|||--||  1 [P] COG1863 Multisubunit Na+/H+ antiporter, MnhE subunit
-||||||||||||-----------------------||----------------------------  1 [S] COG1865 Uncharacterized conserved protein
|||||||||||||||||-------------------------------------------------  1 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase
|||----|||--|------|--||----|-------------|||||-|--|-------|--||||  1 [S] COG1872 Uncharacterized conserved protein
||||||-||-||-----|||------|||-----|--|-----------|||---|---||-|---  1 [R] COG1878 Predicted metal-dependent hydrolase
|||-----||--------------------------------------------------------  1 [C] COG1880 CO dehydrogenase/acetyl-CoA synthase epsilon subunit
-|||--||||--------------------------------------------------------  1 [S] COG1885 Uncharacterized protein conserved in archaea
||--|||||||||-----------------------------------------------------  1 [S] COG1888 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1889 Fibrillarin-like rRNA methylase
||||||||||||||||--------------------------------------------------  1 [J] COG1890 Ribosomal protein S3AE
|||-----||--------------------------------------------------------  1 [S] COG1891 Uncharacterized protein conserved in archaea
||||||||||||||||---|-------------------------------------------|--  1 [O] COG1899 Deoxyhypusine synthase
-|||--|||||-|-----------------------------------|-----------------  1 [S] COG1901 Uncharacterized conserved protein
|||-||--||||------|||---------|----|----------|--|-----|---|-|----  1 [H] COG1903 Cobalamin biosynthesis protein CbiD
|||---||||-||-----------------------------------------------------  1 [R] COG1907 Predicted archaeal sugar kinases
|||-----||--------------------------------------------------------  1 [C] COG1908 Coenzyme F420-reducing hydrogenase, delta subunit
|||-|||||||||-----------------------------------------------------  1 [S] COG1909 Uncharacterized protein conserved in archaea
-|||||--|-|-------------------|-----|------------------|----------  1 [P] COG1910 Periplasmic molybdate-binding protein/domain
|||---||||||||||--------------------------------------------------  1 [J] COG1911 Ribosomal protein L30E
-|||--|||||||---||-|-------------|||-------||-----------||--------  1 [S] COG1912 Uncharacterized conserved protein
-|-|--|||||||---|-------------------------------------------------  1 [R] COG1913 Predicted Zn-dependent proteases
||------||--------||----------------------------------------------  1 [S] COG1915 Uncharacterized conserved protein
||||--||||--------------||--------------------------|-------------  1 [S] COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein)
||||||||--||----|||||-----||--|||--|||-------||--|-----||||||||---  1 [S] COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain
|||----|||-------||--|--------||--||------|||||-||--|--|-||----|--  1 [P] COG1918 Fe2+ transport system protein A
||||----||-----------------|||------------------------------------  1 [S] COG1920 Uncharacterized conserved protein
||--|----|------|-------------------------|||||--|||----|||||-|---  1 [E] COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]
-|--------------||------------|---||||----|||||-||||||||----||||--  1 [R] COG1923 Uncharacterized host factor I protein
|||-----||--------------------------------------------------------  1 [C] COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase
||||----|----------|---------------|----------|-------------------  1 [P] COG1930 ABC-type cobalt transport system, periplasmic component
||||--|||||||-----------------------------------------------------  1 [S] COG1931 Uncharacterized protein conserved in archaea
||||||||||--------------------------------------------------------  1 [L] COG1933 Archaeal DNA polymerase II, large subunit
-||---||||--------------------------------------------------------  1 [S] COG1935 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)
|||||||||||||-----------------------------------------------------  1 [R] COG1938 Archaeal enzymes of ATP-grasp superfamily
||||-----|-----------------||-------------|||||--|||-------||-|---  1 [S] COG1944 Uncharacterized conserved protein
||||||||||------------||------------------------------------------  1 [S] COG1945 Uncharacterized conserved protein
||||--||||||||||--------------------------------------------------  1 [L] COG1948 ERCC4-type nuclease
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain
-|----------------------------------------||||||||||||||---|||||||  1 [U] COG1952 Preprotein translocase subunit SecB
-||||||||--||-----------------------------------------------------  1 [NU] COG1955 Archaeal flagella assembly protein J
|||-----||--------------------------------------------------------  1 [H] COG1962 Tetrahydromethanopterin S-methyltransferase, subunit H
|||-|||||||||--------------||-------------------------------------  1 [R] COG1964 Predicted Fe-S oxidoreductases
||||--|||---------------------------------------------------------  1 [S] COG1967 Predicted membrane protein
|||-----||-|------------------------------------------------------  1 [O] COG1973 Hydrogenase maturation factor
||||||||||||||||--------------------------------------------------  1 [J] COG1976 Translation initiation factor 6 (eIF-6)
||--|||||||||---|-------------------------------------------------  1 [G] COG1980 Archaeal fructose 1,6-bisphosphatase
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis
||--||--|||||------------------------|----|||||-|-----------------  1 [S] COG1986 Uncharacterized conserved protein
|||---||||--|-----------------|---||||----|||||--|-|--------------  1 [R] COG1988 Predicted membrane-bound metal-dependent hydrolases
||||||||||||||||----------|---------------------------------------  1 [S] COG1990 Uncharacterized conserved protein
||||--||-||||----|------------------------------------------------  1 [S] COG1992 Uncharacterized conserved protein
-||---||-|------||---------||--------------------------------|-|--  1 [S] COG1993 Uncharacterized conserved protein
|||||||||||||||---------------|-----------------------------------  1 [K] COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger)
||||||||||||||||--------------------------------------------------  1 [J] COG1997 Ribosomal protein L37AE/L43A
|||||||||||||||---------------------------------------------------  1 [J] COG1998 Ribosomal protein S27AE
||-------|-------|------------------------------------------------  1 [R] COG2000 Predicted Fe-S protein
||||||||||||||||--------------------------------------------------  1 [J] COG2004 Ribosomal protein S24E
||||||||||||||||--------------------------------------------------  1 [J] COG2007 Ribosomal protein S8E
||||||||||||||||--------------------------------------------------  1 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5
|||---||----------------------------------------------------------  1 [S] COG2014 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2016 Predicted RNA-binding protein (contains PUA domain)
||--||||-||||------------------------------------------------|----  1 [F] COG2019 Archaeal adenylate kinase
||||||||||-|||||--------------------------------------------------  1 [J] COG2023 RNase P subunit RPR2
|||-----||--------------------------------------------------------  1 [J] COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type)
-|----|||---------------------------------------------------------  1 [S] COG2028 Uncharacterized conserved protein
|||---||-|--------------------------------------------------------  1 [S] COG2029 Uncharacterized conserved protein
|||---|||--------|------|-----|-----------------------------------  1 [C] COG2033 Desulfoferrodoxin
|||-||||||-||-----------------------------------------------------  1 [S] COG2034 Predicted membrane protein
|||-----||--------------------------------------------------------  1 [C] COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase
|||||||||||||-----||||----|||||------|----|||-|-||-----|---|||||--  1 [H] COG2038 NaMN:DMB phosphoribosyltransferase
||||||---|-|-|||--------------------------------------------------  1 [S] COG2042 Uncharacterized conserved protein
|||-----||--------------------------------------------------------  1 [S] COG2043 Uncharacterized protein conserved in archaea
||------||||----|--------------------------------|----------------  1 [R] COG2044 Predicted peroxiredoxins
||--||---|-------|||-|--------|-----|------------------|----------  1 [HR] COG2045 Phosphosulfolactate phosphohydrolase and related enzymes
||||||||||--------------------------------------------------------  1 [R] COG2047 Uncharacterized protein (ATP-grasp superfamily)
||||||||||||||||--------------------------------------------------  1 [J] COG2051 Ribosomal protein S27E
||||||||||||||||--------------------------------------------------  1 [J] COG2053 Ribosomal protein S28E/S33
|||-----||--------------------------------------------------------  1 [R] COG2054 Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases
||----||-|----------------|---|-----|-----|||-|--|||-------||||---  1 [C] COG2055 Malate/L-lactate dehydrogenases
||||||||||||||||--------------------------------------------------  1 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2
-|---------------|||||---||---------||-|--------||-----|---||-||--  1 [P] COG2059 Chromate transport protein ChrA
|||-----||--------------------------------------------------------  1 [E] COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase
|||-----||--------------------------------------------------------  1 [C] COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein)
||-|||--||||------|||---------|----|----------|--|-----|---||||---  1 [H] COG2073 Cobalamin biosynthesis protein CbiG
||--||||-|-----------|--------------------------------------------  1 [G] COG2074 2-phosphoglycerate kinase
||||||||||||||||--------------------------------------------------  1 [J] COG2075 Ribosomal protein L24E
|||||||||||||||-||------------|-----------------------------------  1 [S] COG2078 Uncharacterized conserved protein
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2082 Precorrin isomerase
||----||||--------------------------------------------------------  1 [S] COG2083 Uncharacterized protein conserved in archaea
||||----||---------|------|----|--------------------|--|---||-|---  1 [R] COG2085 Predicted dinucleotide-binding enzymes
-||-----------------|---|-----|-----|----------------|--|||----|--  1 [M] COG2089 Sialic acid synthase
||-|--|||||||-----------------------------------------------------  1 [S] COG2090 Uncharacterized protein conserved in archaea
|||||||||||||||---------------------------------------------------  1 [J] COG2092 Translation elongation factor EF-1beta
|||||||||||||-----------------------------------------------------  1 [K] COG2093 DNA-directed RNA polymerase, subunit E''
||||||||||||||||--------------------------------------------------  1 [J] COG2097 Ribosomal protein L31E
||||||--||--------------------------------------------------------  1 [S] COG2098 Uncharacterized protein conserved in archaea
||----------------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2099 Precorrin-6x reductase
-|----|||||-|-----------------------------------------------------  1 [R] COG2100 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB
||||||||||||||||--------------------------------------------------  1 [R] COG2102 Predicted ATPases of PP-loop superfamily
-||---|---||------||-|--------------||----|||||-||-----|----------  1 [S] COG2105 Uncharacterized conserved protein
-|||--|||||||-----------------|-----------------------------------  1 [R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme
||||--||---------|||-|----|-------||||----------||---------|||--||  1 [P] COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit
-|----|||-|||---|-------------------------------------------------  1 [T] COG2112 Predicted Ser/Thr protein kinase
||||--||----------------------------------------------------------  1 [J] COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain
|||||||||||||||---------------------------------------------------  1 [R] COG2118 DNA-binding protein
|||-----||----------------------------------------------------|---  1 [S] COG2122 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2125 Ribosomal protein S6E (S10)
||||||||||-|||||--------------------------------------------------  1 [J] COG2126 Ribosomal protein L37E
|||---|||||||---|-------------------------------------------|-----  1 [R] COG2129 Predicted phosphoesterases, related to the Icc protein
|||---||||||||||--------------------------------------------------  1 [JA] COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain
||||----||||------||-|----|||-----|-||-----------------|----------  1 [S] COG2138 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2139 Ribosomal protein L21E
||||----||-|-------|-|----||||--||||||-|--|||||--|--|--|---|||||--  1 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
||||||||||||||||--------------------------------------------------  1 [J] COG2147 Ribosomal protein L19E
|||-||||-||||----|---|----||||-|||||||----|---------|--|---|||||--  1 [R] COG2151 Predicted metal-sulfur cluster biosynthetic enzyme
|||---||||||||||--------------------------------------------------  1 [J] COG2157 Ribosomal protein L20A (L18A)
|||-----||--------------------|-----------------------------------  1 [R] COG2158 Uncharacterized protein containing a Zn-finger-like domain
||----||-|||||||--------------|------|----------------------------  1 [J] COG2163 Ribosomal protein L14E/L6E/L27E
||||||||||-|||||--------------------------------------------------  1 [J] COG2167 Ribosomal protein L39E
||----||-|||||||--------------------------------------------------  1 [J] COG2174 Ribosomal protein L34E
-||---|||||||-|---------------------------------------------------  1 [J] COG2178 Predicted RNA-binding protein of the translin family
-|------------------|---|-----------------|||||---||---|---||||---  1 [R] COG2215 ABC-type uncharacterized transport system, permease component
||||||||||||||||--------------------------------------------------  1 [L] COG2219 Eukaryotic-type DNA primase, large subunit
||||||||||||||---|||||----|||-|-||||||----|||||-||-||--|--|||||--|  1 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold
||-------|---||-|----|-----||------------------------||-----------  1 [R] COG2229 Predicted GTPase
|||-||-----|----||----------------||--------------------|||-------  1 [L] COG2231 Uncharacterized protein related to Endonuclease III
|||-----||--------------------------------------------------------  1 [R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase
-||||||||-|||-----------------------------------------------------  1 [S] COG2237 Predicted membrane protein
||||||||||||||||--------------------------------------------------  1 [J] COG2238 Ribosomal protein S19E (S16A)
||||||--||||------|||-----|||-|----|----------|--|-----|---||||---  1 [H] COG2241 Precorrin-6B methylase 1
||||||--||||------|||-----|||-|----|----------|--|---------||||---  1 [H] COG2242 Precorrin-6B methylase 2
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2243 Precorrin-2 methylase
-|----||--|-|----|------------------------------------------------  1 [S] COG2245 Predicted membrane protein
-|----||----------------------------|-----------------------------  1 [M] COG2247 Putative cell wall-binding domain
-|----|||||||-----------------------------------------------------  1 [R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)
-|----|||||||----|------------------------------------------------  1 [S] COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
-|-|--||------|--|||||--|||---||||||||-|--|||||-||||-||||||-||-|--  1 [R] COG2252 Permeases
-|----|||-|||-----------------------------------------------------  1 [L] COG2254 Predicted HD superfamily hydrolase, possibly a nuclease
|||||||||||||||---------------------------------------------------  1 [J] COG2260 Predicted Zn-ribbon RNA-binding protein
-|||--||-||||---||||||||--||||||||||||----|||||-||-|||||---|||||--  1 [R] COG2262 GTPases
|||||||||||||--|--------------------------------------------------  1 [J] COG2263 Predicted RNA methylase
|||||||||||||-----------------------------------------------------  1 [H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase
||-|-----|---------|-|-----|||----|-------||||---|-----|--||||||--  1 [E] COG2303 Choline dehydrogenase and related flavoproteins
-||---------------||-|---|-||--|--|-||-----------|-----|----------  1 [S] COG2314 Predicted membrane protein
-|-------|-------|--||---------------------------------|----------  1 [G] COG2342 Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase
-|-------------------|-------------|--------|-----|-|||-----------  1 [S] COG2369 Uncharacterized protein, homolog of phage Mu protein gp30
-|----||----|--------|--------------------------------------------  1 [S] COG2383 Uncharacterized conserved protein
-||-|||||-|-|-----------------|-----------|||---------------------  1 [C] COG2414 Aldehyde:ferredoxin oxidoreductase
||-|------|||-----------------------------------------------------  1 [S] COG2429 Uncharacterized conserved protein
||||||||||--||||--------------------------------------------------  1 [U] COG2443 Preprotein translocase subunit Sss1
|||----||-|-----|-----------------|-||----------------------------  1 [S] COG2445 Uncharacterized conserved protein
||||||||||--------------------------------------------------------  1 [S] COG2450 Uncharacterized conserved protein
-|--||-|---|-------|-------||-----------------------|-------------  1 [L] COG2452 Predicted site-specific integrase-resolvase
|||---||-|-|------------------|-----------------------------------  1 [S] COG2454 Uncharacterized conserved protein
||----||----------------------------------------------------------  1 [S] COG2456 Uncharacterized conserved protein
|||---||||-|------------------------------------------------------  1 [S] COG2457 Uncharacterized conserved protein
-|||--|||---------------------------------------------------------  1 [S] COG2469 Uncharacterized conserved protein
||----||-|---------|-------------------------|---|---||----|-|----  1 [S] COG2510 Predicted membrane protein
|||||||||||||-----------------------------------------------------  1 [J] COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain)
||||--|||||||-|--|------------------------|||||-||--||||||||||||--  1 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase
||-||||||||||||-||--------||||------------------------------------  1 [J] COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases
-|----||-||-|---------------------------------------|-------------  1 [R] COG2521 Predicted archaeal methyltransferase
||||----|-|||-----------------------------------------------------  1 [K] COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains
-|--------------|-------------|-----------------||-----|--|-------  1 [P] COG2703 Hemerythrin
|||------|--------|||---------|-----------------------------|-|---  1 [C] COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains
|||||||||------------|--------------------------------------------  1 [C] COG2811 Archaeal/vacuolar-type H+-ATPase subunit H
-|----||-|-|-----|---|---------|||||||----||||||||||-------|||||--  1 [J] COG2813 16S RNA G1207 methylase RsmC
-|||----|-------|----|--||----|-----||----|||||-||||||||||||||||||  1 [M] COG2834 Outer membrane lipoprotein-sorting protein
-||------||||-------------|---||-|-|-----------------||-----------  1 [S] COG2848 Uncharacterized conserved protein
-|--------------|---|---------------------||||||-|||-||||||---||--  1 [M] COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase
-||||||||--||-----------------------------------------------------  1 [NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2875 Precorrin-4 methylase
||||----|---------------------------------------------------------  1 [S] COG2881 Uncharacterized protein conserved in archaea
|||||||||||||-----------------------------------------------------  1 [J] COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG2890 Methylase of polypeptide chain release factors
|||---||||--|-----------------------------------------------------  1 [S] COG2892 Uncharacterized protein conserved in archaea
-|----------------------------------------|||||-||||-------|||||--  1 [S] COG2983 Uncharacterized conserved protein
-|----------------------------------------|||||-|--|--------------  1 [S] COG3013 Uncharacterized conserved protein
-|-------|--|-----------------------------------|-----------------  1 [R] COG3044 Predicted ATPase of the ABC class
|||-----||-----------------|||------------|||||-||-|-|||----------  1 [H] COG3161 4-hydroxybenzoate synthetase (chorismate lyase)
-|----||------------------|||--------------------|-----|----------  1 [R] COG3233 Predicted deacetylase
||||----||--------------------------------------------------------  1 [H] COG3252 Methenyltetrahydromethanopterin cyclohydrolase
||||||--|||-------------------------------------------------------  1 [R] COG3269 Predicted RNA-binding protein, contains TRAM domain
|||||||||||-||||--------------------------------------------------  1 [J] COG3277 RNA-binding protein involved in rRNA processing
-|----||-||-|-----------------------------------------------------  1 [S] COG3286 Uncharacterized protein conserved in archaea
-|-------|---------|----------------------------||----------|-|---  1 [S] COG3287 Uncharacterized conserved protein
|||---|-|---|------------------|-----|----------|-----------------  1 [R] COG3291 FOG: PKD repeat
-|-|------|-|--------|--------------------------------------------  1 [S] COG3294 Uncharacterized conserved protein
-|-|||||----------------------------------------------------------  1 [N] COG3352 Putative archaeal flagellar protein C
-|-|||-|----------------------------------------------------------  1 [N] COG3353 Putative archaeal flagellar protein F
-|-|||||----------------------------------------------------------  1 [N] COG3354 Putative archaeal flagellar protein G
||-|-----|--------------------------------------------------------  1 [F] COG3363 Archaeal IMP cyclohydrolase
-|--||||----------------------------------------------------------  1 [S] COG3373 Uncharacterized protein conserved in archaea
-||-||-----|-||----|------|||-|------------------------|---|--||--  1 [G] COG3387 Glucoamylase and related glycosyl hydrolases
-|||----|---------------------------------------------------------  1 [S] COG3398 Uncharacterized protein conserved in archaea
||||||||||||||||---------|-----||||||--------|-----------------|--  1 [I] COG3425 3-hydroxy-3-methylglutaryl CoA synthase
-|---|--|---------------------------------------------------------  1 [S] COG3466 Putative transposon-encoded protein
-|-|-------------|-|------|---------------------------------------  1 [S] COG3472 Uncharacterized conserved protein
-||-----------------|----------|----|-----------------------------  1 [R] COG3478 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain
-|-------|----------|---------||||||||----------------------|-----  1 [R] COG3481 Predicted HD-superfamily hydrolase
-|-----------------|----------|-----|------------|-----|------|---  1 [R] COG3541 Predicted nucleotidyltransferase
|||----------------|||-----|||--|----------------|---------||-||--  1 [R] COG3576 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase
-||---------------|-|---------------------|||||-||-|-------|--|---  1 [L] COG3593 Predicted ATP-dependent endonuclease of the OLD family
-||||||||-|||------|-------||--------------||||-----|--|---||-||--  1 [K] COG3609 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain
||||||||||||||||--------------------------------------------------  1 [T] COG3642 Mn2+-dependent serine/threonine protein kinase
-|------------------|---------------------|||-|---|---------------  1 [S] COG3681 Uncharacterized conserved protein
||-|--------------------------------------------------------------  1 [S] COG3815 Predicted membrane protein
-||-----|||---------------||||||-|-|-------------|---||-----------  1 [T] COG3830 ACT domain-containing protein
|||||||||||||---||||||--|-||||||||||||-||||||||-||-||--|--|||||---  1 [G] COG3839 ABC-type sugar transport systems, ATPase components
-|--||-|--|||----|--|------------|-----------||------------||-|---  1 [G] COG3958 Transketolase, C-terminal subunit
-|--||-|--|||----|--|------------|-----------||------------||-|---  1 [G] COG3959 Transketolase, N-terminal subunit
-|----------------------------|-----|-------------------|-|----|--  1 [M] COG3980 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase
|||------|--------------------------------------------------------  1 [R] COG4002 Predicted phosphotransacetylase
|||------|--------------------------------------------------------  1 [K] COG4008 Predicted metal-binding transcription factor
||-------|--------------------------------------------------------  1 [S] COG4009 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4010 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4013 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4014 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family
||-------|--------------------------------------------------------  1 [S] COG4016 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4017 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4018 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4019 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4020 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4022 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4024 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4029 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein
|||------|--------------------------------------------------------  1 [S] COG4033 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4035 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4036 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4037 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4038 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4039 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4040 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4041 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4042 Predicted membrane protein
|||------|--------------------------------------------------------  1 [S] COG4048 Uncharacterized protein conserved in archaea
-|----||-|--------------------------------------------------------  1 [R] COG4049 Uncharacterized protein containing archaeal-type C2H2 Zn-finger
|||------|--------------------------------------------------------  1 [S] COG4050 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4051 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [R] COG4052 Uncharacterized protein related to methyl coenzyme M reductase subunit C
||-------|--------------------------------------------------------  1 [S] COG4053 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [H] COG4056 Methyl coenzyme M reductase, subunit C
|||------|--------------------------------------------------------  1 [H] COG4059 Tetrahydromethanopterin S-methyltransferase, subunit E
|||------|--------------------------------------------------------  1 [H] COG4060 Tetrahydromethanopterin S-methyltransferase, subunit D
|||------|--------------------------------------------------------  1 [H] COG4061 Tetrahydromethanopterin S-methyltransferase, subunit C
|||------|--------------------------------------------------------  1 [H] COG4062 Tetrahydromethanopterin S-methyltransferase, subunit B
|||------|--------------------------------------------------------  1 [H] COG4063 Tetrahydromethanopterin S-methyltransferase, subunit A
|||------|--------------------------------------------------------  1 [H] COG4064 Tetrahydromethanopterin S-methyltransferase, subunit G
|||------|--------------------------------------------------------  1 [S] COG4065 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4066 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4069 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [O] COG4070 Predicted peptidyl-prolyl cis-trans isomerase (rotamase), cyclophilin family
||-------|--------------------------------------------------------  1 [S] COG4071 Uncharacterized protein conserved in archaea
-|----||-|--------------------------------------------------------  1 [S] COG4072 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4073 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase
||-------|--------------------------------------------------------  1 [R] COG4076 Predicted RNA methylase
||-------|--------------------------------------------------------  1 [S] COG4077 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4078 Predicted membrane protein
|||------|--------------------------------------------------------  1 [S] COG4079 Uncharacterized protein conserved in archaea
-|-------||||-----------------------------------------------------  1 [L] COG4080 RecB-family nuclease
|||------|--------------------------------------------------------  1 [S] COG4081 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4084 Uncharacterized protein conserved in archaea
||-------|--------------------------||----------------------------  1 [R] COG4085 Predicted RNA-binding protein, contains TRAM domain
-|-------|---||---------------------------------------------------  1 [F] COG4088 Predicted nucleotide kinase
|||------|--------------------------------------------------------  1 [S] COG4090 Uncharacterized protein conserved in archaea
-|-----------------|-------------|----||-------------------------|  1 [S] COG4095 Uncharacterized conserved protein
||--------------|-||-|---|----------------|||||-||||---|--|||--|--  1 [S] COG4121 Uncharacterized conserved protein
-||----------------------------|-|||||-------------------------|--  1 [R] COG4152 ABC-type uncharacterized transport system, ATPase component
-|------|-|||----|||||----|------|---|----|||||--|-----|--|||||---  1 [E] COG4177 ABC-type branched-chain amino acid transport system, permease component
-|--------------|---------|---------------------------------|-----  1 [R] COG4186 Predicted phosphoesterase or phosphohydrolase
|||------|--------------------------------------------------------  1 [H] COG4218 Tetrahydromethanopterin S-methyltransferase, subunit F
||||--------------------------------------------------------------  1 [S] COG4746 Uncharacterized protein conserved in archaea
-||-----|---------------------------------------------------------  1 [K] COG4800 Predicted transcriptional regulator with an HTH domain
-||---||----------------------------------------------------------  1 [G] COG4809 Archaeal ADP-dependent phosphofructokinase/glucokinase
-|------|-|-------------------------------------------------------  1 [R] COG4880 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats
-||------|--------------------------------------------------------  1 [R] COG4887 Uncharacterized metal-binding protein conserved in archaea
-||----|----------------------------------------------------------  1 [S] COG4902 Uncharacterized protein conserved in archaea
-||-----------------|---------------------------------------------  1 [S] COG4907 Predicted membrane protein
-||------|--------------------------------------------------------  1 [S] COG4921 Uncharacterized protein conserved in archaea
-|---------------|-|-|----|-------------------|------------|------  1 [R] COG4928 Predicted P-loop ATPase
|||---------------------------------------------------------------  1 [J] COG4937 Predicted regulatory domain of prephenate dehydrogenase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG4992 Ornithine/acetylornithine aminotransferase
|||---|-|-------||--|---|-------|-------------|-||-|------|-------  1 [C] COG5016 Pyruvate/oxaloacetate carboxyltransferase
||||||||||||||||--------------------------------------------------  1 [J] COG5256 Translation elongation factor EF-1alpha (GTPase)
||||||||||||||||--------------------------------------------------  1 [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)
-||---||-||-------------------------------------------------------  1 [J] COG5270 PUA domain (predicted RNA-binding domain)
-|-----|----|-----------------------------------------------------  1 [R] COG5378 Predicted nucleotide-binding protein
-||---||----------------------------------------------------------  1 [S] COG5418 Predicted secreted protein