(Ecu) Encephalitozoon_cuniculi Functional categories Fun All J A K L B D Y V T M N Z W U O C G E F H I P Q R S COGs 696 141 24 80 61 19 36 -  3 27 7 1 12 -  49 72 23 32 14 15 5 23 14 3 79 47 proteins 1,120 185 27 166 137 31 54 -  13 67 14 1 27 -  60 137 31 42 26 22 11 29 22 8 216 57 Distribution of COGs by number of proteins proteins 1 2 3 4 5 6 7 8 9 11 13 14 17 27 38 COGs 544 80 29 13 10 5 2 5 1 1 1 2 1 1 1

Co-ocurrences in sister taxa No sister genomes in order Apansporoblastina

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
--|----------|||-|||||--------------------------|----------|||||-- 38 [R] COG2319 FOG: WD40 repeat
---|||----||-||||-||-|||--||||||||||||||||-|-|--|||||--||--|--|--- 27 [RTKL] COG0515 Serine/threonine protein kinase
|||||||||||||||||-||-|----------------------------------------|--- 17 [R] COG1100 GTPase SAR1 and related small G proteins
||||||||||||||||-----------|||------------------------------------ 14 [O] COG0638 20S proteasome, alpha and beta subunits
-------------|||--||----|-----------------------|-------||-------- 14 [R] COG0724 RNA-binding proteins (RRM domain)
|-||||||||||||||-------------------------------------------------- 13 [K] COG1958 Small nuclear ribonucleoprotein (snRNP) homolog
|||-||--|--|-||||-||||--|-||||||||||||||||||||||||||||||||-||||||| 11 [LKJ] COG0513 Superfamily II DNA and RNA helicases
-------------|||--------------------------------------------------  9 [K] COG5576 Homeodomain-containing transcription factor
|||||||||--|-|||||||||||||----||||||||----|||||-||-|||||||||||||||  8 [R] COG0457 FOG: TPR repeat
||||||||||||||||||||||||||||||||||||||--||||||||||||||||||||||||||  8 [O] COG0459 Chaperonin GroEL (HSP60 family)
||||||||||||||||--------------------------------------------------  8 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family
--|----------|||---|----------|-|--|------|||||--|-----|----------  8 [S] COG4886 Leucine-rich repeat (LRR) protein
-------------|||--------------------------------------------------  8 [O] COG5078 Ubiquitin-protein ligase
||||--||||-|||||--------------------------------------------------  7 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit
---|---------|||-|||-|--||----|---------|||||-|-||--|||-||||||||--  7 [O] COG2214 DnaJ-class molecular chaperone
|||||||||||||||||||||||||-||||-|||||||||||||||||||||||||||||||||||  6 [L] COG0470 ATPase involved in DNA replication
--||-||||--|||||-|||||||--|||-||||-|||--|||||||-|||||-------|-----  6 [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
--||--||--||-|||||||||||--||||||||||||||||||||||||||||||||||||||||  6 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components
-||||||||----|||||||||--||||||||||||||||||-------|--|||----|||||--  6 [D] COG1196 Chromosome segregation ATPases
-------------|||--------------------------------------------------  6 [Z] COG5059 Kinesin-like protein
||||||||||||||||--||-|----||||------||-----------|-----|--|||-|---  5 [O] COG0464 ATPases of the AAA+ class
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  5 [GEPR] COG0477 Permeases of the major facilitator superfamily
|||||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  5 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins
-|||||||||||||||-|||||--------||-|-|||----||||||||||||||--|||-||--  5 [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
|||||||||||||-||||||||--|||||-||||||||----||||||||--||||||||||||||  5 [M] COG0668 Small-conductance mechanosensitive channel
-------------|||------||--|---------------|||||-||||-||-|||-------  5 [E] COG0814 Amino acid permeases
|-||||||||||||||-|||-|---||||||||||||||||-|||||-||-|||||||-|||||--  5 [V] COG1131 ABC-type multidrug transport system, ATPase component
-------------|||--------------------------------------------------  5 [TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family
-------------|||--------------------------------------------------  5 [O] COG5272 Ubiquitin
-------------|||--------------------------------------------------  5 [R] COG5273 Uncharacterized protein containing DHHC-type Zn finger
|-||||-------|||||||||||||||||||||||||||||||||||||||||||||||||||||  4 [O] COG0443 Molecular chaperone
|||-|--------||||-|||-----||||||||-||||||||||||--|----------|||---  4 [P] COG0474 Cation transport ATPase
|-|||||||-|||||||-||||----|||||--|||||----|||||-||||||||||||||||--  4 [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
|||||||||||||||||||||||||-||||||||||||----||||||||||||||||||||||||  4 [QR] COG0500 SAM-dependent methyltransferases
-------------|||-----|--------------------|||||-||||-|||||||||||--  4 [R] COG0790 FOG: TPR repeat, SEL1 subfamily
||||||||||||||||-|--|---------||||||||----------------------------  4 [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a)
|||||||||-||||||--------------------------------------------------  4 [K] COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS
-------------|||-----|--|||---------------|||||-||||||||---|||||--  4 [L] COG1643 HrpA-like helicases
||||--||||---|||--------------------------------------------------  4 [B] COG2036 Histones H3 and H4
---------------|------||----------------------------|-----------||  4 [C] COG3202 ATP/ADP translocase
-------------|||--------------------------------------------------  4 [R] COG5048 FOG: Zn-finger
-------------|||--------------------------------------------------  4 [BK] COG5076 Transcription factor involved in chromatin remodeling, contains bromodomain
-------------|||---|----------------------------------------------  4 [TZDR] COG5126 Ca2+-binding protein (EF-Hand superfamily)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  3 [K] COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  3 [K] COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
-|-|--||||||||||-|||||||--|||-||||||||----|||||-||||||||--||||||--  3 [J] COG0144 tRNA and rRNA cytosine-C5-methylases
-------------||||||||||||||||||||||||||||||||||-||||||||||||||||||  3 [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase
|||-----||---|||----||----||||||||||||-|||||||||||||||||---|||||--  3 [F] COG0207 Thymidylate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  3 [J] COG0255 Ribosomal protein L29
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  3 [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI)
--|----------|||-|--||||--||||||||||||||||||||||||||||||---|||||-|  3 [H] COG0262 Dihydrofolate reductase
--|-||----||-|||--||-|----||||-|||--------|||||-||||||||---|||||--  3 [E] COG0308 Aminopeptidase N
||||||||||||||||---|----------------------|||||-||----------------  3 [L] COG0417 DNA polymerase elongation subunit (family B)
||||||||||||||||||||||----|||||||||||||---|||||-||||||||--||||||--  3 [R] COG0456 Acetyltransferases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  3 [J] COG0480 Translation elongation factors (GTPases)
|||||||||||||||||-||||----|||||-||-|||----||||||||||||||||||||||--  3 [O] COG0501 Zn-dependent protease with chaperone function
|||||-||||-|-||||||-|------||||---|---|||||||-|--|--|---|--------|  3 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits
-||---||-|||||||-||||----|----||||||||||||------|----||-----------  3 [R] COG1161 Predicted GTPases
||||||||--|||||||-|||-----|||-||||||||----|||||-||||||||-------|--  3 [KL] COG1199 Rad3-related DNA helicases
|||||||||||||||||-||-|----|||||-----||-------||--|--||||--||||||--  3 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)
-||||||-|-||||||--||-|--------------------------||-----|---||-||--  3 [J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing
-------------|||--||------||||------------------------------------  3 [L] COG4581 Superfamily II RNA helicase
-------------|||--------------------------------------------------  3 [DZ] COG5019 Septin family protein
-------------|||--------------------------------------------------  3 [Z] COG5023 Tubulin
-------------|||--------------------------------------------------  3 [O] COG5046 Protein involved in Mod5 protein sorting
-------------|||--------------------------------------------------  3 [R] COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins
-------------|||--------------------------------------------------  3 [KAD] COG5147 Myb superfamily proteins, including transcription factors and mRNA splicing factors
-------------|||--------------------------------------------------  3 [U] COG5158 Proteins involved in synaptic transmission and general secretion, Sec1 family
-------------|||--------------------------------------------------  3 [K] COG5169 Heat shock transcription factor
-------------|||--------------------------------------------------  3 [K] COG5190 TFIIF-interacting CTD phosphatases, including NLI-interacting factor
-------------|||--------------------------------------------------  3 [R] COG5210 GTPase-activating protein
-------------|||--------------------------------------------------  3 [Z] COG5277 Actin and related proteins
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases
||||||||||||||||--||||--||----|||||||||||||||||||-|||-------------  2 [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases
||||----||---|||||||||||||||||||||||||----|||||-||||||||||||||||||  2 [J] COG0042 tRNA-dihydrouridine synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0087 Ribosomal protein L3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0089 Ribosomal protein L23
|||||||||||--||||||||||||||||||||||||||-||||||||||||||||||||||||||  2 [J] COG0101 Pseudouridylate synthase
||||||||||||||||||||-|||||||||||||||||-|||||||||||||||||||||||||||  2 [E] COG0112 Glycine/serine hydroxymethyltransferase
||||--|||||||||||-||-|------------|-||----------||---|||---|||||--  2 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
||||||||||||||||||||||||||||||||||||||----|||||-||||||||--||||||--  2 [F] COG0127 Xanthosine triphosphate pyrophosphatase
-|--||||-----||||-||||||---|||----|-||----|||||-||||||||||||||||||  2 [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes
||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit
--||-|-------|||||||||||||----|||-||||----||||||||||||||---|||||||  2 [L] COG0249 Mismatch repair ATPase (MutS family)
||||||--||---|||--------||----------------||||||||||||||---|||||||  2 [J] COG0293 23S rRNA methylase
--||---------|||||||||||||----||||||||----||||||||||||||---|||||||  2 [L] COG0323 DNA mismatch repair enzyme (predicted ATPase)
-------------|||--||--||----------|-||----||||||||--|||----|-|-|--  2 [P] COG0369 Sulfite reductase, alpha subunit (flavoprotein)
|---||----|--|||--|-------||||------------|||-|--------|----|-|---  2 [G] COG0380 Trehalose-6-phosphate synthase
||||||||||||||||||||||----|||||--|||||----|||||-||||||||||||||||||  2 [D] COG0489 ATPases involved in chromosome partitioning
||||||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||  2 [O] COG0492 Thioredoxin reductase
||||||||||||||||||||-|||||||||||||||||||--||||||||||||||||||||||||  2 [F] COG0504 CTP synthase (UTP-ammonia lyase)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0522 Ribosomal protein S4 and related proteins
|||||||||-|||||||-||||||-|||||||||||||||||||||||||||||||||||||||||  2 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
--|----------||||-||-|||--||||||-|||||----||||||||||||||---|||||||  2 [FJ] COG0590 Cytosine/adenosine deaminases
|||||||||||||||||--------------|--|||----------------------------|  2 [MI] COG0615 Cytidylyltransferase
||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K
|-||---------|||--||||--|-||||||||||||----|||||-||||||||||||||||--  2 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
-------------||||||||||||-|||||||-||||----|||||-||||||||--||||||--  2 [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
----||----|--|||--||||--|||---|-----------||||--||-|||||--|||-||||  2 [R] COG0666 FOG: Ankyrin repeat
|---|||||||||||||--|||----||||-----|||----|||||-||||||||---|||||||  2 [J] COG0689 RNase PH
|-||----|----|||-|||-|----|||||||||||-----|||||-||||||||---|||||||  2 [O] COG0695 Glutaredoxin and related proteins
|-|||||||-|||||||||||||||-|||-||-|||||----||||||||||||||||||||||||  2 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
-------------|||--||-|-----||-----|-||----|||----|-----||||-------  2 [R] COG0699 Predicted GTPases (dynamin-related)
-------------||||---|-|||-||||||||-||-----||||||-|||||||||-|||||||  2 [F] COG0756 dUTPase
|-||||||||||||||-|||-|----||||||||||||----|||||-||-||--|||-|||||--  2 [V] COG0842 ABC-type multidrug transport system, permease component
---|----|-|-|||||-|||---||||||---------------|--||||--------------  2 [I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
--|||||||-||||||||||||||--||||||||||||----||||||||||||||||||||||||  2 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
||||||||||||||||--------------------------------------------------  2 [R] COG1094 Predicted RNA-binding protein (contains KH domains)
||||||||||||||||--------------------------------------------------  2 [K] COG1095 DNA-directed RNA polymerase, subunit E'
|-|-||||||||||||--------------------------------------------------  2 [J] COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)
|||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||  2 [G] COG1109 Phosphomannomutase
||||||||||||||||--------------------------------------------------  2 [R] COG1163 Predicted GTPase
|||||||||||||||||-------------------------|----------------||-----  2 [R] COG1204 Superfamily II helicase
------||||||||||--------------------------------------------------  2 [K] COG1224 DNA helicase TIP49, TBP-interacting protein
|-|||||||||||||||-||-|-----||--------------||||--|-----|----------  2 [R] COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily
--||----|-|-|||||-||||----|||||-||--||||------|-||--||||--|||-|---  2 [O] COG1404 Subtilisin-like serine proteases
||||||||||||||||--------------------------------------------------  2 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
||||||||||||||||--------------------------------------------------  2 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
|-|||||||-||||||--------------------------------------------------  2 [LO] COG1474 Cdc6-related protein, AAA superfamily ATPase
||||||||||||||||--------------------------------------------------  2 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog
----||--|-|--|||-||||-||--|---||||||||||--||||||||||||||||-|||||||  2 [I] COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes
||||||||||-|||||--------------------------------------------------  2 [L] COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
||||||||||||||||--------------------------------------------------  2 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain
||||||||||||||||--------------------------------------------------  2 [J] COG1736 Diphthamide synthase subunit DPH2
||||||||||||||||--------------------------------------------------  2 [K] COG1761 DNA-directed RNA polymerase, subunit L
-------------|||||--||--|-----||--||||----------------------------  2 [S] COG1774 Uncharacterized homolog of PSP1
||||--||||||||||--------------------------------------------------  2 [L] COG1948 ERCC4-type nuclease
||||||||||||||||--------------------------------------------------  2 [J] COG2007 Ribosomal protein S8E
||||||||||||||||--------------------------------------------------  2 [J] COG2075 Ribosomal protein L24E
------------|--|-----|-|-|-||||---|||------------|---------||-|-||  2 [L] COG2094 3-methyladenine DNA glycosylase
|||---||||||||||--------------------------------------------------  2 [JA] COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain
||----||-|||||||--------------|------|----------------------------  2 [J] COG2163 Ribosomal protein L14E/L6E/L27E
-------------|||------||-|--------|-------------------------------  2 [G] COG4284 UDP-glucose pyrophosphorylase
-------------|||------||-----------------------------------|------  2 [S] COG4286 Uncharacterized conserved protein related to MYG1 family
----------||||||--------------------------------------------------  2 [J] COG4901 Ribosomal protein S25
-------------|||--------------------------------------------------  2 [O] COG5021 Ubiquitin-protein ligase
-------------|||--------------------------------------------------  2 [Z] COG5022 Myosin heavy chain
-------------|||--------------------------------------------------  2 [D] COG5024 Cyclin
-------------|||--------------------------------------------------  2 [K] COG5025 Transcription factor of the Forkhead/HNF3 family
-------------|||--------------------------------------------------  2 [B] COG5027 Histone acetyltransferase (MYST family)
-------------|||--------------------------------------------------  2 [U] COG5028 Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3
-------------|||--------------------------------------------------  2 [TG] COG5037 Gluconate transport-inducing protein
-------------|||--------------------------------------------------  2 [O] COG5044 RAB proteins geranylgeranyltransferase component A (RAB escort protein)
-------------|||--------------------------------------------------  2 [U] COG5052 Protein involved in membrane traffic
-------------|||--------------------------------------------------  2 [J] COG5053 Translation initiation factor 4E (eIF-4E)
-------------|||--------------------------------------------------  2 [S] COG5062 Uncharacterized membrane protein
-------------|||--------------------------------------------------  2 [U] COG5096 Vesicle coat complex, various subunits
-------------|||--------------------------------------------------  2 [U] COG5143 Synaptobrevin/VAMP-like protein
||||||||||||||||--------------------------------------------------  2 [J] COG5256 Translation elongation factor EF-1alpha (GTPase)
-------------|||--------------------------------------------------  2 [T] COG5329 Phosphoinositide polyphosphatase (Sac family)
-------------|||--------------------------------------------------  2 [U] COG5347 GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport
-------------|||--------------------------------------------------  2 [K] COG5641 GATA Zn-finger-containing transcription factor
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [E] COG0006 Xaa-Pro aminopeptidase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||---|||||||  1 [J] COG0009 Putative translation factor (SUA5)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0012 Predicted GTPase, probable translation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0013 Alanyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0018 Arginyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [I] COG0020 Undecaprenyl pyrophosphate synthase
-------------|||||||-||||-||||||||||||||||||||||||||||||||||||||--  1 [G] COG0021 Transketolase
---|||----||||||--||-|||---||--|||||||-|||-------|-----|---|||||||  1 [C] COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [J] COG0024 Methionine aminopeptidase
||||||-|||---|||--||-|----|||--|-||||-----|||||-||-||------|--|---  1 [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0030 Dimethyladenosine transferase (rRNA methylation)
-|--||-------||||||||||||-||||||||||||||||||||||||||||||||||||||--  1 [G] COG0036 Pentose-5-phosphate-3-epimerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0048 Ribosomal protein S12
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0049 Ribosomal protein S7
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0051 Ribosomal protein S10
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0052 Ribosomal protein S2
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||--  1 [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0060 Isoleucyl-tRNA synthetase
|||||||||||||||||||||---|||||||||||||||-||||||||||||||||||||||||||  1 [G] COG0061 Predicted sugar kinase
||||||||||||||||||||-|----||||||--|||-----|||||-||--||||||||||||--  1 [G] COG0063 Predicted sugar kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [R] COG0073 EMAP domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0080 Ribosomal protein L11
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0081 Ribosomal protein L1
|||---||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0084 Mg-dependent DNase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0088 Ribosomal protein L4
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0090 Ribosomal protein L2
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0091 Ribosomal protein L22
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0092 Ribosomal protein S3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0093 Ribosomal protein L14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0094 Ribosomal protein L5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0096 Ribosomal protein S8
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0097 Ribosomal protein L6P/L9E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0098 Ribosomal protein S5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0099 Ribosomal protein S13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0100 Ribosomal protein S11
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0102 Ribosomal protein L13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0103 Ribosomal protein S9
|||||||||||||||||-||-||||||||||--|||||----|||||-||||||||||||||||||  1 [F] COG0105 Nucleoside diphosphate kinase
||||||||||||||||--||-|||||----||||||------||||||||||||||---|||||--  1 [G] COG0120 Ribose 5-phosphate isomerase
|-||--|||---||||--|--|-----||-|-----||-|--|||||-||--|--|---|||||--  1 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0124 Histidyl-tRNA synthetase
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [F] COG0125 Thymidylate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0126 3-phosphoglycerate kinase
||||||||||||||||||||||||||||||||||||||||--||||||||||||||--||||||||  1 [J] COG0130 Pseudouridine synthase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [H] COG0142 Geranylgeranyl pyrophosphate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0143 Methionyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0148 Enolase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0149 Triosephosphate isomerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0162 Tyrosyl-tRNA synthetase
||||||||||||||||||||||||-|||||||||||||----|||||-||||||||||||||||||  1 [L] COG0164 Ribonuclease HII
-|-|||----||||||||||||||||||||||||||||-|||||||||||||||||||||||||--  1 [G] COG0166 Glucose-6-phosphate isomerase
|||-|||||||--||||-||----||--------------------------------------||  1 [I] COG0170 Dolichol kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0172 Seryl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [L] COG0177 Predicted EndoIII-related endonuclease
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0180 Tryptophanyl-tRNA synthetase
||||||||||||||||--|-||---||||||||-||||----|||||-|||----|||-|||||||  1 [I] COG0183 Acetyl-CoA acetyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0184 Ribosomal protein S15P/S13E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0185 Ribosomal protein S19
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0186 Ribosomal protein S17
--||||--|----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
--||||--|----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
-------------|||||||||||--||||||||||||||||||||||||||||||||||||||||  1 [F] COG0194 Guanylate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0197 Ribosomal protein L16/L10E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0198 Ribosomal protein L24
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0199 Ribosomal protein S14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0200 Ribosomal protein L15
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0201 Preprotein translocase subunit SecY
-------------||||||||||||||||||||||||||||||||||||-|||------||-|---  1 [G] COG0205 6-phosphofructokinase
---|-------|-||||-|-|||||-||||||||||||-|||||||||||||||||||||-|-|||  1 [F] COG0208 Ribonucleotide reductase, beta subunit
|-|||||||-|||||||||-|||||-||||||||||||-|||||||||||||||||||||||||||  1 [F] COG0209 Ribonucleotide reductase, alpha subunit
--|||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0215 Cysteinyl-tRNA synthetase
-------------||||||||||||-||||||||||||||||||||||||||||||||||||||||  1 [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase
|-||||||-|-||||||-||||||--|||||----|-|||||||||||||||||||||||||||||  1 [C] COG0221 Inorganic pyrophosphatase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  1 [H] COG0237 Dephospho-CoA kinase
|-------|----|||||||||||||||||||||||||||--|||||-||||||||||||||||||  1 [C] COG0240 Glycerol-3-phosphate dehydrogenase
-|--||-------|||--|-|------||-|-----------|||||||||||||||||---||--  1 [E] COG0241 Histidinol phosphatase and related phosphatases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0244 Ribosomal protein L10
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0256 Ribosomal protein L18
------------|-|||-||||||--||||----|-|||||||||||||||||-||||||||||||  1 [E] COG0260 Leucyl aminopeptidase
---|---------|||--||----------------------||||||||||||||---|||||||  1 [O] COG0278 Glutaredoxin-related protein
---------------||||||||||||||||||||||||||||||||-||||||||---|||||||  1 [F] COG0283 Cytidylate kinase
--|----|---|-|||---||-----||||||||||||-----------|-|---|---||-||--  1 [R] COG0300 Short-chain dehydrogenases of various substrate specificities
-------------|||--|||---|||||||----|||----|||||||||||--||||-|-|-||  1 [O] COG0326 Molecular chaperone, HSP90 family
||||--||||---|||---|||||||||-|||||||||||--||||||||||-||||||-------  1 [S] COG0327 Uncharacterized conserved protein
|||||||||||||-||||||||||-||---||||||||----||||||||||||||||||||||||  1 [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0361 Translation initiation factor 1 (IF-1)
-------------|||-|||--||||||||-|-||||-----|||||||-||-||----||||---  1 [G] COG0362 6-phosphogluconate dehydrogenase
-------------|||-||||-||||||||||||||||-|--|||||-||||||||||-|||||--  1 [G] COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase
-------------|||||||-||||||||--|-||||-----||||||||||||||||-|||||--  1 [G] COG0364 Glucose-6-phosphate 1-dehydrogenase
|-||||--|-|||||||-||-|-----||--|--||||----|||||-||-||--||-||||||--  1 [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases
|||||||||||-||||----------||||||---|||----|||||-||--|-------|-|---  1 [E] COG0367 Asparagine synthase (glutamine-hydrolyzing)
-------------|||--|-|-----|---|||||||||---|||||--|--||||-------|--  1 [O] COG0386 Glutathione peroxidase
----||----||||||--||||----|||-----|-||----|||-|-||--||||||-||-||--  1 [E] COG0405 Gamma-glutamyltransferase
||||||||||||||||||||||--||----||--|||-----|||||-||----------------  1 [L] COG0419 ATPase involved in DNA repair
||||||||||||||||||||||--||||||||--||||----|||||-||----------|-----  1 [L] COG0420 DNA repair exonuclease
||||||||||||||||-----|--|||||||---|---||||------------------------  1 [J] COG0423 Glycyl-tRNA synthetase (class II)
||||--||--||||||||-|-|---||||------|------|||-|--|---|||--|-|-----  1 [P] COG0428 Predicted divalent heavy-metal cations transporter
-------------|-|--||----------------------|||||-||---|||----------  1 [R] COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold
||||--|||||||||||--|----------------------|||-|--|-----|----------  1 [A] COG0430 RNA 3'-terminal phosphate cyclase
||||||||||||||||||||||---|||||||||||||----|||||-||||||||||||||||||  1 [M] COG0438 Glycosyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0441 Threonyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0442 Prolyl-tRNA synthetase
||||||||-||||||||||||||||-||||||||||||----||||||||||||||||||||||--  1 [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
|||-|||||-|||||||||||||||--|||-||-||||----||||||||-||--|||||||||||  1 [O] COG0450 Peroxiredoxin
|||||||||-||||||||||||||--|||||||||||||---|||||-||||||||||||||||-|  1 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
||||||||||||||||||||||---||||||||||||||||||||||-||||||||||||||||||  1 [M] COG0463 Glycosyltransferases involved in cell wall biogenesis
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [L] COG0468 RecA/RadA recombinase
-|||||||--||||||-|||||||-|||||||||||||||||||||||||||||||--||||||--  1 [G] COG0469 Pyruvate kinase
-|||--||||||||||--------------------------------------------------  1 [T] COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
|-||||-------|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain
-------------|||--||||||||||||||||||||-|--||||||||||||||||||||||||  1 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains
||||||||||||||||||||||----||||||||||||----||||||||||||||||||||||--  1 [R] COG0491 Zn-dependent hydrolases, including glyoxylases
--|-||||--|-|||||||--|--|-||||||--||||----|||||-||--|--|--||||||||  1 [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
|-||||--|-|||||||||||||||-||||||||||||----||||||||||||||||||||||||  1 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0495 Leucyl-tRNA synthetase
--|---------||||--||||--|-|---||--||||----|||||-||||||||---||-||--  1 [L] COG0514 Superfamily II DNA helicase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0525 Valyl-tRNA synthetase
||||||--||||||||--|||-||--|||||||||||||||||||||-|||||--|---|||||||  1 [E] COG0531 Amino acid transporters
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0532 Translation initiation factor 2 (IF-2; GTPase)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0533 Metal-dependent proteases with possible chaperone activity
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0541 Signal recognition particle GTPase
|------------||||||||||||||||||||||||||-|||||||-||||||||||||||||||  1 [O] COG0542 ATPases with chaperone activity, ATP-binding subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0550 Topoisomerase IA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0552 Signal recognition particle GTPase
---|---------||||||||||||-|---||||||||||||||||||||||||||||||||||--  1 [K] COG0557 Exoribonuclease R
|-|||||||-|||||||||||-|||||||||||||||||||||||||-||||||||||||||||||  1 [I] COG0558 Phosphatidylglycerophosphate synthase
|-||||||||||||||-||||||||||||||||||||||||||||||||-||-|||---||-|---  1 [R] COG0561 Predicted hydrolases of the HAD superfamily
--||--|||----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0563 Adenylate kinase and related kinases
-------------|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0564 Pseudouridylate synthases, 23S RNA-specific
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [I] COG0575 CDP-diglyceride synthetase
---|||-----|-|||--|--|---|||||-|||||||----|||||-|||||--|---||||---  1 [C] COG0578 Glycerol-3-phosphate dehydrogenase
|-------|--|-|||-||-||---|----||||||||-|||||||||-||||--|---|||||--  1 [G] COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
---|||-|--|-||||-|-|||--|-||||||||||||-||||||||-||||---|---|||||--  1 [C] COG0584 Glycerophosphoryl diester phosphodiesterase
|||||||||||||||||----|--------------------|||||-||||----|||-------  1 [S] COG0585 Uncharacterized conserved protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
--||||--|-|||||||-||||---|||||||-||||||||||||||-||||||||||||||||||  1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 
|-||||----|||||||-||-|||-|||||||||||||----||||||||||||||||||||||||  1 [P] COG0605 Superoxide dismutase
|-||||--|-||-||||-||||---|||||||||||||----|||||||||||||||||||-||||  1 [P] COG0607 Rhodanese-related sulfurtransferase
-------------|||||||||||||||||||||||||----||||||||||||||||||||||||  1 [J] COG0617 tRNA nucleotidyltransferase/poly(A) polymerase
---|---------||||-||-|||--|---------------||||||||||-|||---|||||||  1 [C] COG0633 Ferredoxin
||||||||--||||||||----||---||||---|||||||||||||||-----------------  1 [L] COG0648 Endonuclease IV
---|||||--||||||-||-------||||||||||||----|||||--|-----|---|||||--  1 [R] COG0656 Aldo/keto reductases, related to diketogulonate reductase
--|----------||||-||--||--||||-|---|||----|||-|-||-|---|||-||-|---  1 [P] COG0659 Sulfate permease and related transporters (MFS superfamily)
||||--||-|-|-||||-||||--|-||||||||||||----|||||-|||||--|||-|||||||  1 [I] COG0671 Membrane-associated phospholipid phosphatase
||||||||||||||||||||||||||||||||||||||-|--||||||||||||||||||||||||  1 [U] COG0681 Signal peptidase I
-------------|||----||||-|||||-||||||||||||||||||||||||||||||-----  1 [L] COG0692 Uracil DNA glycosylase
--||-----------|--||----------|---|||||||||||||-||------||||------  1 [G] COG0696 Phosphoglyceromutase
|-|-||--|--|-|||--||||--|||||-||||-||-----|||||-||||||||||||||||||  1 [L] COG0708 Exonuclease III
--|--|-|-|---|||-|||||||---|||||||||||----|||||-||--|--|||-|||||--  1 [G] COG0726 Predicted xylanase/chitin deacetylase
-------------|||||||||--||----||||||||----||||||||||||||||||||||||  1 [O] COG0760 Parvulin-like peptidyl-prolyl isomerase
|-||--|||----|||-|||-|--||-||-|----|||----|||||-|||||--|||||||||--  1 [T] COG0784 FOG: CheY-like receiver
--||----|----|||||-||-||||||||||||||||||||||||||||||-|||||||||||||  1 [C] COG0822 NifU homolog involved in Fe-S cluster formation
------||||||||||||--||----|||||-|-||||-|--|||||-||-|---||||----|--  1 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family
----|---|----||||||--||||-|||-||||||||----||||||||||||||||||||||||  1 [L] COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases
||||--||-|||-|||-|-|-|--|||||-||||||||----|||||-||-|-|||---|||||--  1 [R] COG1011 Predicted hydrolase (HAD superfamily)
-------------|||------||------------------|||||-||----------------  1 [O] COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like
--|||||||-||||||---|||--|-|||||-||||------|||||-|-----------------  1 [KL] COG1061 DNA or RNA helicases of superfamily II
---|||----||||||--||-|||---||--|||||||-|||-------|-----|---|||||||  1 [C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit
--||---||---||||-|-|||||--|||-|||--|||----|||||-||-||--|---|||||--  1 [R] COG1073 Hydrolases of the alpha/beta superfamily
-------------|||--|-----------------------||||||||||-|||--||||||||  1 [O] COG1076 DnaJ-domain-containing proteins 1
|||||||||||||--|||--|----------||||||||-||------------------------  1 [R] COG1078 HD superfamily phosphohydrolases
||||||||||||||||--------------------------------------------------  1 [R] COG1084 Predicted GTPase
||||||||||||||||--------------------------------------------------  1 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)
--|-----|----||||||||||||-||||||||||||----||||||||||-|||||||||||||  1 [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B
--|-------||-|||||||||||--|||||||||||||||||||||||||||||||||||-----  1 [J] COG1190 Lysyl-tRNA synthetase (class II)
|-|-||||||||-||||-||------|---|||-||||----|||||--|-----|---|||||-|  1 [M] COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
-|------|----|||-|--||--------|||||||-----------|-----------------  1 [C] COG1227 Inorganic pyrophosphatase/exopolyphosphatase
--|---|---||-|||||-|-|----|--||||||||-----|||||--|-|||||--||||||--  1 [P] COG1230 Co/Zn/Cd efflux system component
||||||||||||||||-|||-|||||||||||||||||----|||-|----|---|------||--  1 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
||||||||||||-|||-|--|---------|-----------------------------------  1 [KB] COG1243 Histone acetyltransferase
||||||||||||||||--------------------------------------------------  1 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
||||||||||||||||---------|-----|||||------------|-----------------  1 [I] COG1257 Hydroxymethylglutaryl-CoA reductase
|||||||||||||--|--------------------------------------------------  1 [J] COG1258 Predicted pseudouridylate synthase
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I
-------------|||----||--|||||-||||||||----|||||-||--|||----|||||--  1 [R] COG1272 Predicted membrane protein, hemolysin III homolog
||||||||||||||||-|||||---|----||||||||------------------|||-------  1 [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP
|||||||||||-||||--------------------------------------------------  1 [K] COG1308 Transcription factor homologous to NACalpha-BTF3
||||||||||---|||--------------------------------------------------  1 [L] COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
|-|-|||||||-|--|||-|-|-|------------------|||||-----|--|--------||  1 [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations
-|----||||--||||--------------------------------------------------  1 [J] COG1374 Protein involved in ribosomal biogenesis, contains PUA domain
||||||||||||||||--------------------------------------------------  1 [J] COG1383 Ribosomal protein S17E
|||||||||||-||||----||||||----------------------------------------  1 [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D
||||||||||||||||--------------------------------------------------  1 [U] COG1400 Signal recognition particle 19 kDa protein
|-||---------|||--||--||||--------|-||----||-----|------------|---  1 [C] COG1413 FOG: HEAT repeat
---||-----|----|-|---|---|----|||||||||||||||||-|-||-------||-|---  1 [F] COG1435 Thymidine kinase
||||||||||||||||----||--|--------|--------------------------------  1 [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F
||||||||||||||||--------------------------------------------------  1 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
---|---------|||----------|||-------------|||-|-------------------  1 [I] COG1443 Isopentenyldiphosphate isomerase
---|--||||||||||--------------------------|||||-|-||--------------  1 [R] COG1444 Predicted P-loop ATPase fused to an acetyltransferase
||||||||||||||||--------------------------------------------------  1 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit
||||||||||||||||--------------------------------------------------  1 [J] COG1471 Ribosomal protein S4E
||||||||||||||||--------------------------------------------------  1 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay
||||||||||||||||--------------------------------------------------  1 [J] COG1500 Predicted exosome subunit
|||||||||||||||||-------------------------------------------------  1 [J] COG1503 Peptide chain release factor 1 (eRF1)
----|||||--|-|||-|-|------|---|----|-|-----------|--|-----|-|-||--  1 [R] COG1524 Uncharacterized proteins of the AP superfamily
|||||||||||--|||----||----------||--------------------------------  1 [C] COG1527 Archaeal/vacuolar-type H+-ATPase subunit C
|-|-----|------|-|--------|||-|---|--||---|||||-|-||----|||-------  1 [P] COG1528 Ferritin-like protein
||||||||||||||||--------------------------------------------------  1 [R] COG1537 Predicted RNA-binding proteins
||||||||||||||||--------------------------------------------------  1 [J] COG1552 Ribosomal protein L40E
||||--||||||||||---------|-----|||||------------------------------  1 [I] COG1577 Mevalonate kinase
-------------|||---|----||----------------|||-|--|-----|----------  1 [G] COG1626 Neutral trehalase
||||||||||||||||--------------------------------------------------  1 [J] COG1631 Ribosomal protein L44E
||||||||||||||||--------------------------------------------------  1 [J] COG1632 Ribosomal protein L15E
||||||||||||||||--------------------------------------------------  1 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
||||--||||||||||--------------------------------------------------  1 [K] COG1675 Transcription initiation factor IIE, alpha subunit
||||||||||||||||--------------------------------------------------  1 [J] COG1676 tRNA splicing endonuclease
|||||||||||||--|||-|-|----|||-|------|----|||-|--|-----|----------  1 [S] COG1690 Uncharacterized conserved protein
||||--||||||||||--------------------------------------------------  1 [L] COG1697 DNA topoisomerase VI, subunit A
||||||||||||||||--------------------------------------------------  1 [J] COG1717 Ribosomal protein L32E
||||||||||||||||-----|-----------------------|---|----------------  1 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control
-------------|||---|--||----------------------------------------||  1 [S] COG1723 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1727 Ribosomal protein L18E
-------------||||||-|---|--|||-|----||----|||-|-||--||||---|||||||  1 [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily
-|--||||||||||||--------------------------------------------------  1 [S] COG1756 Uncharacterized conserved protein
||||||||||||||||||||-|--||||||||||||||----|||||-||||||||||||||||||  1 [K] COG1758 DNA-directed RNA polymerase, subunit K/omega
|||||||||||||||||----------||-------||----------|||--||---|||-||--  1 [L] COG1793 ATP-dependent DNA ligase
||||||||||||||||--------------------------------------------------  1 [J] COG1798 Diphthamide biosynthesis methyltransferase
||||||||||||||||--------------------------------------------------  1 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1
||||||||||||||||||--||--||||||||||||||----||||||||||||||----||||||  1 [J] COG1841 Ribosomal protein L30/L7E
|||||||||||||||||-------------------------------------------------  1 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase
|---||----|--|||----------||||------------|||-|--------|------|---  1 [G] COG1877 Trehalose-6-phosphatase
||||||||||||||||--------------------------------------------------  1 [J] COG1889 Fibrillarin-like rRNA methylase
||||||||||||||||--------------------------------------------------  1 [J] COG1890 Ribosomal protein S3AE
||||||||||||||||---|-------------------------------------------|--  1 [O] COG1899 Deoxyhypusine synthase
|||---||||||||||--------------------------------------------------  1 [J] COG1911 Ribosomal protein L30E
-------------|||--||------||||------------------------------------  1 [O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase
||||||||||||||||--------------------------------------------------  1 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)
-------------|-|----------||||------------|||||-|||||------|||||--  1 [I] COG1946 Acyl-CoA thioesterase
-------------|||--------------------------||||||||||-|||--------||  1 [P] COG1965 Protein implicated in iron transport, frataxin homolog
||||||||||||||||--------------------------------------------------  1 [J] COG1976 Translation initiation factor 6 (eIF-6)
||||||||||||||||----------|---------------------------------------  1 [S] COG1990 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1997 Ribosomal protein L37AE/L43A
||||||||||||||||--------------------------------------------------  1 [J] COG2004 Ribosomal protein S24E
||||||||||||||||--------------------------------------------------  1 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5
||||||||||||||||--------------------------------------------------  1 [J] COG2016 Predicted RNA-binding protein (contains PUA domain)
--|---|||---||||--||-------||-|-----------------|-||---|----|||---  1 [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase
||||||||||-|||||--------------------------------------------------  1 [J] COG2023 RNase P subunit RPR2
||||||---|-|-|||--------------------------------------------------  1 [S] COG2042 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2051 Ribosomal protein S27E
||||||||||||||||--------------------------------------------------  1 [J] COG2053 Ribosomal protein S28E/S33
||||||||||||||||--------------------------------------------------  1 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2
||||||||||||||||--------------------------------------------------  1 [J] COG2097 Ribosomal protein L31E
||||||||||||||||--------------------------------------------------  1 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB
||||||||||||||||--------------------------------------------------  1 [R] COG2102 Predicted ATPases of PP-loop superfamily
--|----------|||--||----|-||||-------------------|---------||-||--  1 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)
--|---||-|-|-|||-----|----||||----|-||----|--|-------------||||---  1 [S] COG2120 Uncharacterized proteins, LmbE homologs
|-|-||||||||||||--------------------------------------------------  1 [J] COG2123 RNase PH-related exoribonuclease
||||||||||||||||--------------------------------------------------  1 [J] COG2125 Ribosomal protein S6E (S10)
||||||||||-|||||--------------------------------------------------  1 [J] COG2126 Ribosomal protein L37E
||||||||||||||||--------------------------------------------------  1 [J] COG2139 Ribosomal protein L21E
||||||||||||||||--------------------------------------------------  1 [J] COG2147 Ribosomal protein L19E
|||---||||||||||--------------------------------------------------  1 [J] COG2157 Ribosomal protein L20A (L18A)
||||||||||-|||||--------------------------------------------------  1 [J] COG2167 Ribosomal protein L39E
||----||-|||||||--------------------------------------------------  1 [J] COG2174 Ribosomal protein L34E
-------------|||---||---|-|---|||||||||---|||||-||||||||---||||---  1 [K] COG2183 Transcriptional accessory protein
||||||||||||||||--------------------------------------------------  1 [L] COG2219 Eukaryotic-type DNA primase, large subunit
||||||||||||||||--------------------------------------------------  1 [J] COG2238 Ribosomal protein S19E (S16A)
|||||||||||||--|--------------------------------------------------  1 [J] COG2263 Predicted RNA methylase
--------|----|-|---|||---||---|---||||-----------|---------|||||--  1 [S] COG2340 Uncharacterized protein with SCP/PR1 domains
||||||||||--||||--------------------------------------------------  1 [U] COG2443 Preprotein translocase subunit Sss1
------||-|--||||--------------------------------------------------  1 [J] COG2451 Ribosomal protein L35AE/L33A
||||||||||||||||--------------------------------------------------  1 [R] COG2520 Predicted methyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG2890 Methylase of polypeptide chain release factors
--|----------|||------||----------------------------|--|------|---  1 [R] COG2940 Proteins containing SET domain
-------------|||----------|---||--|||-----|||||-|---|||--------|--  1 [E] COG3104 Dipeptide/tripeptide permease
---|-----------|--|--------|||-------------------|-----------|----  1 [S] COG3268 Uncharacterized conserved protein
|||||||||||-||||--------------------------------------------------  1 [J] COG3277 RNA-binding protein involved in rRNA processing
---|||-----|-|||---------|-----|||||------------------------------  1 [I] COG3407 Mevalonate pyrophosphate decarboxylase
||||||||||||||||---------|-----||||||--------|-----------------|--  1 [I] COG3425 3-hydroxy-3-methylglutaryl CoA synthase
---------------|--|-|---------|---|-----------------|------||-|---  1 [G] COG3588 Fructose-1,6-bisphosphate aldolase
||||||||||||||||--------------------------------------------------  1 [T] COG3642 Mn2+-dependent serine/threonine protein kinase
-------------|||--||----------------------------||-------------|--  1 [O] COG3751 Predicted proline hydroxylase
----------||||||--------------------------------------------------  1 [J] COG4352 Ribosomal protein L13E
-------------|||-|------------|-----------------------------------  1 [R] COG4624 Iron only hydrogenase large subunit, C-terminal domain
----------||-|||--------------------------------------------------  1 [J] COG4830 Ribosomal protein S26
----------||||||--------------------------------------------------  1 [R] COG4888 Uncharacterized Zn ribbon-containing protein
-------------|||--------------------------------------------------  1 [G] COG5020 Mannosyltransferase
-------------|||--------|-----------------------------------------  1 [G] COG5026 Hexokinase
-------------|||--------------------------------------------------  1 [O] COG5029 Prenyltransferase, beta subunit
-------------|||--------------------------------------------------  1 [U] COG5030 Clathrin adaptor complex, small subunit
-------------|||--------------------------------------------------  1 [K] COG5033 Transcription initiation factor IIF, auxiliary subunit
-------------|||--------------------------------------------------  1 [B] COG5034 Chromatin remodeling protein, contains PhD zinc finger
-------------|||--------------------------------------------------  1 [DKT] COG5035 Cell cycle control protein
-------------|||--------------------------------------------------  1 [P] COG5036 SPX domain-containing protein involved in vacuolar polyphosphate accumulation
-------------|||--------------------------------------------------  1 [R] COG5038 Ca2+-dependent lipid-binding protein, contains C2 domain
-------------|||--------------------------------------------------  1 [T] COG5040 14-3-3 family protein
-------------|||--------------------------------------------------  1 [TDK] COG5041 Casein kinase II, beta subunit
-------------|||--------------------------------------------------  1 [U] COG5043 Vacuolar protein sorting-associated protein
-------------|||--------------------------------------------------  1 [J] COG5045 Ribosomal protein S10E
-------------|||--------------------------------------------------  1 [U] COG5047 Vesicle coat complex COPII, subunit SEC23
-------------|||--------------------------------------------------  1 [LDA] COG5049 5'-3' exonuclease
-------------|||--------|-----------------------------------------  1 [I] COG5050 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases
-------------|||--------------------------------------------------  1 [J] COG5051 Ribosomal protein L36E
-------------|||--------------------------------------------------  1 [O] COG5054 Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins
-------------|||--------------------------------------------------  1 [L] COG5055 Recombination DNA repair protein (RAD52 pathway)
-------------|||--------------------------------------------------  1 [I] COG5056 Acyl-CoA cholesterol acyltransferase
-------------|||--------------------------------------------------  1 [DT] COG5057 Phosphotyrosyl phosphatase activator
-------------|||--------------------------------------------------  1 [U] COG5058 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor
-------------|||--------------------------------------------------  1 [OU] COG5061 Oxidoreductin, endoplasmic reticulum membrane-associated protein involved in disulfide bond formation
-------------|||--------------------------------------------------  1 [R] COG5063 CCCH-type Zn-finger protein
-------------|||--------------------------------------------------  1 [U] COG5064 Karyopherin (importin) alpha
-------------|||--------------------------------------------------  1 [P] COG5065 Protein involved in inorganic phosphate transport
-------------|||--------------------------------------------------  1 [U] COG5066 VAMP-associated protein involved in inositol metabolism
-------------|||--------------------------------------------------  1 [LD] COG5067 Protein kinase essential for the initiation of DNA replication
-------------|||--------------------------------------------------  1 [K] COG5068 Regulator of arginine metabolism and related MADS box-containing transcription factors
-------------|||--------------------------------------------------  1 [Z] COG5069 Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily)
-------------|||--------------------------------------------------  1 [GOU] COG5070 Nucleotide-sugar transporter
-------------|||--------------------------------------------------  1 [O] COG5071 26S proteasome regulatory complex component
-------------|||--------------------------------------------------  1 [D] COG5072 Serine/threonine kinase of the haspin family
-------------|||--------------------------------------------------  1 [U] COG5073 Vacuolar import and degradation protein
-------------|||--------------------------------------------------  1 [U] COG5074 t-SNARE complex subunit, syntaxin
-------------|||--------------------------------------------------  1 [S] COG5075 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [O] COG5077 Ubiquitin carboxyl-terminal hydrolase
-------------|||--------------------------------------------------  1 [UD] COG5079 Nuclear protein export factor
-------------|||--------------------------------------------------  1 [U] COG5080 Rab GTPase interacting factor, Golgi membrane protein
-------------|||--------------------------------------------------  1 [S] COG5081 Predicted membrane protein
-------------|||--------------------------------------------------  1 [OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger
-------------|||--------------|-----------------------------------  1 [R] COG5083 Uncharacterized protein involved in plasmid maintenance
-------------|||--------------------------------------------------  1 [S] COG5085 Predicted membrane protein
-------------|||--------------------------------------------------  1 [S] COG5086 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [S] COG5087 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [R] COG5088 Rad5p-binding protein
-------------|||--------------------------------------------------  1 [K] COG5090 Transcription initiation factor IIF, small subunit (RAP30)
-------------|||--------------------------------------------------  1 [R] COG5091 Suppressor of G2 allele of skp1 and related proteins
-------------|||--------------------------------------------------  1 [I] COG5092 N-myristoyl transferase
-------------|||--------------------------------------------------  1 [S] COG5093 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [K] COG5094 Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA)
-------------|||--------------------------------------------------  1 [K] COG5095 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA)
-------------|||--------------------------------------------------  1 [K] COG5097 RNA polymerase II transcriptional regulation mediator
-------------|||--------------------------------------------------  1 [BD] COG5098 Chromosome condensation complex Condensin, subunit D2
-------------|||--------------------------------------------------  1 [J] COG5099 RNA-binding protein of the Puf family, translational repressor
-------------|||--------------------------------------------------  1 [U] COG5100 Nuclear pore protein
-------------|||--------------------------------------------------  1 [U] COG5101 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily)
-------------|||--------------------------------------------------  1 [U] COG5102 Membrane protein involved in ER to Golgi transport
-------------|||--------------------------------------------------  1 [DK] COG5103 Cell division control protein, negative regulator of transcription
-------------|||--------------------------------------------------  1 [A] COG5104 Splicing factor
-------------|||--------------------------------------------------  1 [D] COG5105 Mitotic inducer, protein phosphatase
-------------|||--------------------------------------------------  1 [S] COG5106 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [A] COG5107 Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor
-------------|||--------------------------------------------------  1 [R] COG5109 Uncharacterized conserved protein, contains RING Zn-finger
-------------|||--------------------------------------------------  1 [O] COG5110 26S proteasome regulatory complex component
-------------|||--------------------------------------------------  1 [K] COG5111 DNA-directed RNA polymerase III, subunit C34
-------------|||--------------------------------------------------  1 [R] COG5112 U1-like Zn-finger-containing protein
-------------|||--------------------------------------------------  1 [O] COG5113 Ubiquitin fusion degradation protein 2
-------------|||--------------------------------------------------  1 [B] COG5114 Histone acetyltransferase complex SAGA/ADA, subunit ADA2
-------------|||--------------------------------------------------  1 [O] COG5116 26S proteasome regulatory complex component
-------------|||--------------------------------------------------  1 [JU] COG5117 Protein involved in the nuclear export of pre-ribosomes
-------------|||--------------------------------------------------  1 [K] COG5118 Transcription initiation factor TFIIIB, Bdp1 subunit
-------------|||--------------------------------------------------  1 [U] COG5120 Membrane protein involved in Golgi transport
-------------|||--------------------------------------------------  1 [U] COG5122 Transport protein particle (TRAPP) complex subunit
-------------|||--------------------------------------------------  1 [K] COG5123 Transcription initiation factor IIA, gamma subunit
-------------|||--------------------------------------------------  1 [DR] COG5124 Protein predicted to be involved in meiotic recombination
-------------|||--------------------------------------------------  1 [S] COG5125 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [C] COG5127 Vacuolar H+-ATPase V1 sector, subunit C
-------------|||--------------------------------------------------  1 [U] COG5128 Transport protein particle (TRAPP) complex subunit
-------------|||--------------------------------------------------  1 [R] COG5129 Nuclear protein with HMG-like acidic region
-------------|||--------------------------------------------------  1 [UT] COG5130 Prenylated rab acceptor 1 and related proteins
-----------|-|||--------------------------------------------------  1 [O] COG5131 Ubiquitin-like protein
-------------|||--------------------------------------------------  1 [KD] COG5132 Cell cycle control protein, G10 family
-------------|||--------------------------------------------------  1 [S] COG5133 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [S] COG5134 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [A] COG5136 U1 snRNP-specific protein C
-------------|||--------------------------------------------------  1 [KB] COG5137 Histone chaperone involved in gene silencing
-------------|||--------------------------------------------------  1 [S] COG5138 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [S] COG5139 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [O] COG5140 Ubiquitin fusion-degradation protein
-------------|||--------------------------------------------------  1 [R] COG5141 PHD zinc finger-containing protein
-------------|||--------------------------------------------------  1 [L] COG5142 Oxidation resistance protein
-------------|||--------------------------------------------------  1 [KL] COG5144 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2
-------------|||--------------------------------------------------  1 [L] COG5145 DNA excision repair protein
-------------|||--------------------------------------------------  1 [O] COG5148 26S proteasome regulatory complex, subunit RPN10/PSMD4
-------------|||--------------------------------------------------  1 [K] COG5149 Transcription initiation factor IIA, large chain
-------------|||--------------------------------------------------  1 [K] COG5150 Class 2 transcription repressor NC2, beta subunit (Dr1)
-------------|||--------------------------------------------------  1 [KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1
-------------|||--------------------------------------------------  1 [R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers
-------------|||--------------------------------------------------  1 [UI] COG5153 Putative lipase essential for disintegration of autophagic bodies inside the vacuole
-------------|||--------------------------------------------------  1 [J] COG5154 RNA-binding protein required for 60S ribosomal subunit biogenesis
-------------|||--------------------------------------------------  1 [DO] COG5155 Separase, a protease involved in sister chromatid separation
-------------|||--------------------------------------------------  1 [DO] COG5156 Anaphase-promoting complex (APC), subunit 10
-------------|||--------------------------------------------------  1 [K] COG5157 RNA polymerase II assessory factor
-------------|||--------------------------------------------------  1 [O] COG5159 26S proteasome regulatory complex component
-------------|||--------------------------------------------------  1 [O] COG5160 Protease, Ulp1 family
-------------|||--------------------------------------------------  1 [A] COG5161 Pre-mRNA cleavage and polyadenylation specificity factor
-------------|||--------------------------------------------------  1 [K] COG5162 Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA)
-------------|||--------------------------------------------------  1 [J] COG5163 Protein required for biogenesis of the 60S ribosomal subunit
-------------|||--------------------------------------------------  1 [K] COG5164 Transcription elongation factor
-------------|||--------------------------------------------------  1 [KLB] COG5165 Nucleosome-binding factor SPN, POB3 subunit
-------------|||--------------------------------------------------  1 [S] COG5166 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [U] COG5167 Protein involved in vacuole import and degradation
-------------|||--------------------------------------------------  1 [T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit
-------------|||--------------------------------------------------  1 [U] COG5171 Ran GTPase-activating protein (Ran-binding protein)
-------------|||--------------------------------------------------  1 [U] COG5173 Exocyst complex subunit SEC6
-------------|||--------------------------------------------------  1 [K] COG5174 Transcription initiation factor IIE, beta subunit
-------------|||--------------------------------------------------  1 [K] COG5175 Transcriptional repressor
-------------|||--------------------------------------------------  1 [A] COG5176 Splicing factor (branch point binding protein)
-------------|||--------------------------------------------------  1 [S] COG5177 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [A] COG5178 U5 snRNP spliceosome subunit
-------------|||--------------------------------------------------  1 [K] COG5179 Transcription initiation factor TFIID, subunit TAF1
-------------|||--------------------------------------------------  1 [A] COG5180 Protein interacting with poly(A)-binding protein
-------------|||--------------------------------------------------  1 [A] COG5181 U2 snRNP spliceosome subunit
-------------|||--------------------------------------------------  1 [A] COG5182 Splicing factor 3b, subunit 2
-------------|||--------------------------------------------------  1 [A] COG5183 Protein involved in mRNA turnover and stability
-------------|||--------------|-----------------------------------  1 [DZ] COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing proteins
-------------|||--------------------------------------------------  1 [D] COG5185 Protein involved in chromosome segregation, interacts with SMC proteins
-------------|||--------------------------------------------------  1 [A] COG5186 Poly(A) polymerase
-------------|||--------------------------------------------------  1 [O] COG5187 26S proteasome regulatory complex component, contains PCI domain
-------------|||--------------------------------------------------  1 [A] COG5188 Splicing factor 3a, subunit 3
-------------|||--------------------------------------------------  1 [KD] COG5189 Putative transcriptional repressor regulating G2/M transition
-------------|||--------------------------------------------------  1 [R] COG5191 Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat
-------------|||--------------------------------------------------  1 [J] COG5192 GTP-binding protein required for 40S ribosome biogenesis
-------------|||--------------------------------------------------  1 [OJ] COG5193 La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation
-------------|||--------------------------------------------------  1 [OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex
-------------|||--------------------------------------------------  1 [S] COG5195 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [U] COG5196 ER lumen protein retaining receptor
-------------|||--------------------------------------------------  1 [S] COG5197 Predicted membrane protein
-------------|||--------------------------------------------------  1 [R] COG5198 Protein tyrosine phosphatase-like protein (contains Pro instead of catalytic Arg)
-------------|||--------------------------------------------------  1 [Z] COG5199 Calponin
-------------|||--------------------------------------------------  1 [A] COG5200 U1 snRNP component, mediates U1 snRNP association with cap-binding complex
-------------|||--------------------------------------------------  1 [O] COG5201 SCF ubiquitin ligase, SKP1 component
-------------|||--------------------------------------------------  1 [S] COG5202 Predicted membrane protein
-------------|||--------------------------------------------------  1 [K] COG5204 Transcription elongation factor SPT4
-------------|||--------------------------------------------------  1 [O] COG5206 Glycosylphosphatidylinositol transamidase (GPIT), subunit GPI8
-------------|||--------------------------------------------------  1 [O] COG5207 Isopeptidase T
-------------|||--------------------------------------------------  1 [K] COG5208 CCAAT-binding factor, subunit C
-------------|||--------------------------------------------------  1 [R] COG5209 Uncharacterized protein involved in cell differentiation/sexual development
-------------|||--------------------------------------------------  1 [K] COG5211 RNA polymerase II-interacting protein involved in transcription start site selection
-------------|||--------------------------------------------------  1 [A] COG5213 Polyadenylation factor I complex, subunit FIP1
-------------|||--------------------------------------------------  1 [L] COG5214 DNA polymerase alpha-primase complex, polymerase-associated subunit B
-------------|||--------------------------------------------------  1 [U] COG5215 Karyopherin (importin) beta
-------------|||--------------------------------------------------  1 [S] COG5216 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [DZ] COG5217 Microtubule-binding protein involved in cell cycle control
-------------|||--------------------------------------------------  1 [BD] COG5218 Chromosome condensation complex Condensin, subunit G
-------------|||--------------------------------------------------  1 [R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger
-------------|||--------------------------------------------------  1 [DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3
-------------|||--------------------------------------------------  1 [K] COG5221 Dopey and related predicted leucine zipper transcription factors
-------------|||--------------------------------------------------  1 [R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger
-------------|||--------------------------------------------------  1 [S] COG5223 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [K] COG5224 CCAAT-binding factor, subunit B
-------------|||--------------------------------------------------  1 [J] COG5225 Uncharacterized protein involved in ribosome biogenesis
-------------|||--------------------------------------------------  1 [A] COG5226 mRNA capping enzyme, guanylyltransferase (alpha) subunit
-------------|||--------------------------------------------------  1 [O] COG5227 Ubiquitin-like protein (sentrin)
-------------|||--------------------------------------------------  1 [A] COG5228 mRNA deadenylase subunit
-------------|||--------------------------------------------------  1 [BD] COG5229 Chromosome condensation complex Condensin, subunit H
-------------|||--------------------------------------------------  1 [S] COG5230 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [C] COG5231 Vacuolar H+-ATPase V1 sector, subunit H
-------------|||--------------------------------------------------  1 [U] COG5232 Preprotein translocase subunit Sec62
-------------|||--------------------------------------------------  1 [U] COG5233 Peripheral Golgi membrane protein
-------------|||--------------------------------------------------  1 [OZ] COG5234 Beta-tubulin folding cofactor D
-------------|||--------------------------------------------------  1 [L] COG5235 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit
-------------|||--------------------------------------------------  1 [R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger
-------------|||--------------------------------------------------  1 [S] COG5237 Predicted membrane protein
-------------|||--------------------------------------------------  1 [TA] COG5238 Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport
-------------|||--------------------------------------------------  1 [A] COG5239 mRNA deadenylase, exonuclease subunit and related nucleases
-------------|||--------------------------------------------------  1 [U] COG5240 Vesicle coat complex COPI, gamma subunit
-------------|||--------------------------------------------------  1 [L] COG5241 Nucleotide excision repair endonuclease NEF1, RAD10 subunit
-------------|||--------------------------------------------------  1 [KL] COG5242 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4
-------------|||--------------------------------------------------  1 [O] COG5243 HRD ubiquitin ligase complex, ER membrane component
-------------|||--------------------------------------------------  1 [D] COG5244 Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B
-------------|||--------------------------------------------------  1 [Z] COG5245 Dynein, heavy chain
-------------|||--------------------------------------------------  1 [A] COG5246 Splicing factor 3a, subunit 2
-------------|||--------------------------------------------------  1 [K] COG5247 Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog)
-------------|||--------------------------------------------------  1 [K] COG5248 Transcription initiation factor TFIID, subunit TAF13
-------------|||--------------------------------------------------  1 [U] COG5249 Golgi protein involved in Golgi-to-ER retrieval
-------------|||--------------------------------------------------  1 [K] COG5250 RNA polymerase II, fourth largest subunit
-------------|||--------------------------------------------------  1 [K] COG5251 Transcription initiation factor TFIID, subunit TAF11
-------------|||--------------------------------------------------  1 [R] COG5252 Uncharacterized conserved protein, contains CCCH-type Zn-finger protein
-------------|||--------------------------------------------------  1 [T] COG5253 Phosphatidylinositol-4-phosphate 5-kinase
-------------|||--------------------------------------------------  1 [S] COG5254 Predicted membrane protein
||||||||||||||||--------------------------------------------------  1 [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)
-------------|||--------------------------------------------------  1 [BK] COG5259 RSC chromatin remodeling complex subunit RSC8
-------------|||--------------------------------------------------  1 [L] COG5260 DNA polymerase sigma
-------------|||--------------------------------------------------  1 [DT] COG5261 Protein involved in regulation of cellular morphogenesis/cytokinesis
-------------|||--------------------------------------------------  1 [B] COG5262 Histone H2A
-------------|||--------------------------------------------------  1 [O] COG5264 Vacuolar transporter chaperone
-------------|||--------------------------------------------------  1 [JO] COG5269 Ribosome-associated chaperone zuotin
-------------|||--------------------------------------------------  1 [R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain
-------------|||--------------------------------------------------  1 [CI] COG5274 Cytochrome b involved in lipid metabolism
-------------|||--------------------------------------------------  1 [R] COG5275 BRCT domain type II
-------------|||--------------------------------------------------  1 [K] COG5290 IkappaB kinase complex, IKAP component
-------------|||--------------------------------------------------  1 [S] COG5291 Predicted membrane protein
-------------|||--------------------------------------------------  1 [K] COG5296 Transcription factor involved in TATA site selection and in elongation by RNA polymerase II
-------------|||------------------------------------------------|-  1 [R] COG5307 SEC7 domain proteins
-------------|||--------------------------------------------------  1 [U] COG5308 Nuclear pore complex subunit
-------------|||--------------------------------------------------  1 [U] COG5325 t-SNARE complex subunit, syntaxin
-------------|||--------------------------------------------------  1 [DKL] COG5333 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit
-------------|||--------------------------------------------------  1 [R] COG5354 Uncharacterized protein, contains Trp-Asp (WD) repeat
-------------|||--------------------------------------------------  1 [R] COG5366 Protein involved in propagation of M2 dsRNA satellite of L-A virus
-------------|||--------------------------------------------------  1 [S] COG5369 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [GO] COG5371 Golgi nucleoside diphosphatase
-------------|||--------------------------------------------------  1 [S] COG5374 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [J] COG5384 U3 small nucleolar ribonucleoprotein component
-------------|||--------------------------------------------------  1 [UR] COG5391 Phox homology (PX) domain protein
-------------|||--------------------------------------------------  1 [KLB] COG5406 Nucleosome binding factor SPN, SPT16 subunit
-------------|||--------------------------------------------------  1 [U] COG5407 Preprotein translocase subunit Sec63
-------------|||--------------------------------------------------  1 [T] COG5408 SPX domain-containing protein
-------------|||--------------------------------------------------  1 [T] COG5409 EXS domain-containing protein
-------------|||--------------------------------------------------  1 [T] COG5411 Phosphatidylinositol 5-phosphate phosphatase
-------------|||--------------------------------------------------  1 [K] COG5414 TATA-binding protein-associated factor
-------------|||--------------------------------------------------  1 [R] COG5415 Predicted integral membrane metal-binding protein
-------------|||--------------------------------------------------  1 [T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
-------------|||--------------------------------------------------  1 [T] COG5432 RING-finger-containing E3 ubiquitin ligase
-------------|||------||------------------------------------------  1 [B] COG5531 SWIB-domain-containing proteins implicated in chromatin remodeling
-------------|||--------------------------------------------------  1 [O] COG5533 Ubiquitin C-terminal hydrolase
-------------|||--------------------------------------------------  1 [L] COG5535 DNA repair protein RAD4
-------------|||--------------------------------------------------  1 [O] COG5536 Protein prenyltransferase, alpha subunit
-------------|||--------------------------------------------------  1 [D] COG5537 Cohesin
-------------|||--------------------------------------------------  1 [U] COG5538 Preprotein translocase subunit Sec66
-------------|||--------------------------------------------------  1 [O] COG5539 Predicted cysteine protease (OTU family)
-------------|||--------------------------------------------------  1 [O] COG5540 RING-finger-containing ubiquitin ligase
-------------|||--------------------------------------------------  1 [O] COG5541 Vesicle coat complex COPI, zeta subunit
-------------|||---|----------|-----------------------------------  1 [S] COG5542 Predicted integral membrane protein
-------------|||--------------------------------------------------  1 [S] COG5543 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [O] COG5560 Ubiquitin C-terminal hydrolase
-------------|||--------------------------------------------------  1 [O] COG5574 RING-finger-containing E3 ubiquitin ligase
-------------|||--------------------------------------------------  1 [L] COG5575 Origin recognition complex, subunit 2
-------------|||--------------------------------------------------  1 [O] COG5580 Activator of HSP90 ATPase
-------------|||--------------------------------------------------  1 [J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis
-------------|||--------------------------------------------------  1 [S] COG5594 Uncharacterized integral membrane protein
-------------|||--------------------------------------------------  1 [O] COG5596 Mitochondrial import inner membrane translocase, subunit TIM22
-------------|||--------------------------------------------------  1 [T] COG5599 Protein tyrosine phosphatase
-------------|||--------------------------------------------------  1 [L] COG5600 Transcription-associated recombination protein
-------------|||--------------------------------------------------  1 [K] COG5601 General negative regulator of transcription subunit
-------------|||--------------------------------------------------  1 [B] COG5602 Histone deacetylase complex, SIN3 component
-------------|||--------------------------------------------------  1 [N] COG5603 Subunit of TRAPP, an ER-Golgi tethering complex
-------------|||--------------------------------------------------  1 [S] COG5604 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [A] COG5623 Pre-mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1
-------------|||--------------------------------------------------  1 [K] COG5624 Transcription initiation factor TFIID, subunit TAF12 (also component of histone acetyltransferase SAGA)
-------------|||--------------------------------------------------  1 [L] COG5627 DNA repair protein MMS21
-------------|||--------------------------------------------------  1 [S] COG5629 Predicted metal-binding protein
-------------|||--------------------------------------------------  1 [S] COG5636 Uncharacterized conserved protein, contains Zn-ribbon-like motif
-------------|||--------------------------------------------------  1 [S] COG5638 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [S] COG5644 Uncharacterized conserved protein
-------------|||--------------------------------------------------  1 [O] COG5647 Cullin, a subunit of E3 ubiquitin ligase
-------------|||--------------------------------------------------  1 [B] COG5648 Chromatin-associated proteins containing the HMG domain
-------------|||--------------------------------------------------  1 [O] COG5656 Importin, protein involved in nuclear import
-------------|||--------------------------------------------------  1 [D] COG5657 CAS/CSE protein involved in chromosome segregation
-------------|||--------------------------------------------------  1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit