(Pab) Pyrococcus abyssi Functional categories Fun All J A K L B D Y V T M N Z W U O C G E F H I P Q R S COGs 1,065 149 2 57 59 3 9 -  9 18 29 17 -  -  17 38 71 50 89 46 58 18 51 9 174 163 proteins 1,557 162 2 91 88 4 18 -  22 28 52 28 -  -  25 53 129 91 155 53 73 21 108 19 329 192 Distribution of COGs by number of proteins proteins 1 2 3 4 5 6 7 8 9 12 14 22 COGs 824 147 40 20 16 6 4 3 1 1 2 1

Co-ocurrences in sister taxa 0 1 order Thermococcales 91 974

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
|||---||--||-----||||------------------------|------------|------- 22 [R] COG1672 Predicted ATPase (AAA+ superfamily)
||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||| 14 [GEPR] COG0477 Permeases of the major facilitator superfamily
-|--||||-|--||--|-||-|-----|||------|----------------------------- 14 [L] COG1372 Intein/homing endonuclease
|||||||||||||--------|----|||-|-----||----|||||-||||-|||---|||||-- 12 [K] COG1522 Transcriptional regulators
|||||||||||||||||||||||||-||||||||||||----||||||||||||||||||||||||  9 [QR] COG0500 SAM-dependent methyltransferases
||||||||||||||||||||||---||||||||||||||||||||||-||||||||||||||||||  8 [M] COG0463 Glycosyltransferases involved in cell wall biogenesis
|||||||||||||---||||||----|||||||-||||----|||||-||-|||||--||||||--  8 [K] COG0640 Predicted transcriptional regulators
-|----|||-|||--------|-----||-------------------------------|-----  8 [R] COG1848 Predicted nucleic acid-binding protein, contains PIN domain
||||||||||||||||||||||---|||||||||||||----|||||-||||||||||||||||||  7 [M] COG0438 Glycosyltransferase
|||||||||||||||-||||||||-|||||||||||||----|||||-||||||||||||||||||  7 [R] COG0517 FOG: CBS domain
-|||||||||||-------|----------------------|||||-||---||-----|-|---  7 [C] COG1042 Acyl-CoA synthetase (NDP forming)
|-||||||||||||||-|||-|---||||||||||||||||-|||||-||-|||||||-|||||--  7 [V] COG1131 ABC-type multidrug transport system, ATPase component
|||-|||||||||---||||-|-----||-|------|----||||||||||||||---|||||--  6 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs
|||||||||||||||-||||||--|||||-||||||-|-||||||||-||-|---|---|||||--  6 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases
||||-||||-|||----|||-|----|||-----||||----|||-|-||---------|||--||  6 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit
|-|||||||-|||||||||||||||-|||-||-|||||----||||||||||||||||||||||||  6 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
||||--||-|||-|||-|-|-|--|||||-||||||||----|||||-||-|-|||---|||||--  6 [R] COG1011 Predicted hydrolase (HAD superfamily)
-||-|-||--||-----|--|------||----|-|--------------|-----|||---|--|  6 [R] COG1373 Predicted ATPase (AAA+ superfamily)
-|-|--||||||||||-|||||||--|||-||||||||----|||||-||||||||--||||||--  5 [J] COG0144 tRNA and rRNA cytosine-C5-methylases
--|||||||-|||---||--||||-||---|||||||||||||||||-||||---||||||||---  5 [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
|||||||||-||||||||||||||--|||||||||||||---|||||-||||||||||||||||-|  5 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
|||||||||--|-|||||||||||||----||||||||----|||||-||-|||||||||||||||  5 [R] COG0457 FOG: TPR repeat
||||||||||||||--||||---------------------------------------||-|---  5 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction
|||-||||||-|-||-||--|---|-|||-||-|-|||----|||||-||---|||---|----||  5 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
--|||||||-|||---||||||||-||||||||||||||||||||||-||||---||||||||---  5 [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
--||--|||--------|||-|--||----|----|||----|||||-||--|--||||||-||--  5 [NT] COG0840 Methyl-accepting chemotaxis protein
|||||||||||||---|||||---|--||-||--||-|----|||||-|------||||---||--  5 [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit
--|||||||-|||---||||||||-||||||||||||||||||||||-||||---||-|||||---  5 [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
|-|---||---|----||------------|-----||---------------------||||---  5 [S] COG1633 Uncharacterized conserved protein
|||---|||||||---||------------|---|-----------|---|--------||----|  5 [R] COG1708 Predicted nucleotidyltransferases
||||--||---------|||-|----|-------||||----------||---------|||--||  5 [P] COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit
-||-|||||-|-|-----------------|-----------|||---------------------  5 [C] COG2414 Aldehyde:ferredoxin oxidoreductase
|||||||||||||---||||||--|-||||||||||||-||||||||-||-||--|--|||||---  5 [G] COG3839 ABC-type sugar transport systems, ATPase components
--|||||||-|||---||--||||-||---||||||||-||||||||-||||---||||||||---  5 [E] COG4608 ABC-type oligopeptide transport system, ATPase component
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  4 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
--||||||--|||||----|-|----|||||---|-||----|||||-|||----|---||||---  4 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases
||||||||||------||||||--||||||||||||||-|||||||||||||||||||||||||||  4 [D] COG0206 Cell division GTPase
|-|||||||-|||||||||-|||||-||||||||||||-|||||||||||||||||||||||||||  4 [F] COG0209 Ribonucleotide reductase, alpha subunit
|||||||||||||||||||||||||-||||-|||||||||||||||||||||||||||||||||||  4 [L] COG0470 ATPase involved in DNA replication
|||-|||||-|||||-|-||-|---|-|||||--||||----|||||-|||-||||||||||||||  4 [P] COG0475 Kef-type K+ transport systems, membrane components
|||||||||||||---||||-|-----||-||--|-||-----------|-----|----|-|---  4 [R] COG0535 Predicted Fe-S oxidoreductases
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  4 [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit
--|||||||-|||---||||||||--|||||||-||||----|||||-||||---||||||||---  4 [E] COG0747 ABC-type dipeptide transport system, periplasmic component
|-||||||||||||||-|||-|----||||||||||||----|||||-||-||--|||-|||||--  4 [V] COG0842 ABC-type multidrug transport system, permease component
||||--||---------|||-|----|-------||||----------||---------|||--||  4 [P] COG1006 Multisubunit Na+/H+ antiporter, MnhC subunit
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  4 [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit
|||-|||||||||----|||||--------|-----|-----|||||-|||||||||||||-|---  4 [C] COG1145 Ferredoxin
|||||||||||||||||-||-|----|||||-----||-------||--|--||||--||||||--  4 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)
||||||||||||||||--------------------------------------------------  4 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family
||||--||---------|---|----|-------||||----------||---------|||--||  4 [P] COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit
||||--|||||-|----|-|||--------||||||||||--|||-|--|----------|-----  4 [G] COG1363 Cellulase M and related proteins
-||---|||-||------||-|-----||-----------------|---|-|--|---||-||-|  4 [R] COG1487 Predicted nucleic acid-binding protein, contains PIN domain
||||--||---------|---|----|-------||||----------||---------|||--||  4 [P] COG1863 Multisubunit Na+/H+ antiporter, MnhE subunit
||||||||||-|-----|-|||----|---||||||||----|||||-||||||||---|||||--  4 [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  3 [E] COG0006 Xaa-Pro aminopeptidase
||||||||||||||||--||||--||----|||||||||||||||||||-|||-------------  3 [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases
|||--|||||||-||-||||-|----|||||--|||||----||||||||||||||--||||||--  3 [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  3 [K] COG0195 Transcription elongation factor
||-||||||||||---|-||-|----|||-------||----|||||-||||---|||||||||--  3 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
|||||||||||||||-|||||||||-||||||||||||----|||||-||||||||||||||||||  3 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase
||-|--||||------||-|----||-||||-----||----------||-----||||-------  3 [D] COG0455 ATPases involved in chromosome partitioning
||||||||||||||||--||-|----||||------||-----------|-----|--|||-|---  3 [O] COG0464 ATPases of the AAA+ class
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  3 [E] COG0498 Threonine synthase
|||||||||||||||||-||||----|||||-||-|||----||||||||||||||||||||||--  3 [O] COG0501 Zn-dependent protease with chaperone function
|||||||||||||||--|||-|----||||||||||||----|||||-|||||--|---|||||--  3 [G] COG0524 Sugar kinases, ribokinase family
||||--|||---|||-|||-||--|||||-|||||||||||||||||-||||||||||||||||--  3 [V] COG0534 Na+-driven multidrug efflux pump
|-|||||||--||||---|-|--|--|------||-||----|||||-||||-||||||||||-||  3 [ER] COG0591 Na+/proline symporter
-|--|||||||||||-||--||-|--||||||||||||----||||||||||||||||||||||||  3 [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases
-||||||||-|||---------------------------------------|---||-|||||||  3 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis
||||||||||||||||-----------|||------------------------------------  3 [O] COG0638 20S proteasome, alpha and beta subunits
|||--|||-|-|-----|---------||-------------|||-|-------------------  3 [C] COG0650 Formate hydrogenlyase subunit 4
|-||||||-|||-||-||||-|----|---||||||||----|||||-||-|---|||||||||--  3 [R] COG0673 Predicted dehydrogenases and related proteins
-|||||||-|||----||||-|---|-||-------------|||-|-----|---||--------  3 [L] COG0675 Transposase and inactivated derivatives
|||||||||||||---||||-|---|||||||||||-||-|||||||-||--|--|---|||||--  3 [P] COG0704 Phosphate uptake regulator
|||||||||||||---||||-|---||||||---||||----|||||-||--|--|---|||||--  3 [R] COG0714 MoxR-like ATPases
|||||--||||||---||||||----||||||||||||----|||||-||||||||||||||||--  3 [C] COG0778 Nitroreductase
--|||||||-||||||||||||||--||||||||||||----||||||||||||||||||||||||  3 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
|||---||||-|-----|||------|||||-|-||||----|||||--|-----|---|||||--  3 [G] COG1082 Sugar phosphate isomerases/epimerases
|||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||  3 [G] COG1109 Phosphomannomutase
|||||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  3 [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)
---|||||--|||----|||-|--|-||||||||||||-||||||||-||-||--|---||||---  3 [G] COG1175 ABC-type sugar transport systems, permease components
|-||--||--|-|---|||||||||||||-||||||||-----||||-||-----|------||--  3 [R] COG1266 Predicted metal-dependent membrane protease
--|||||||--||----|||-|--||----|---|||||||--------|-----|----||----  3 [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component
|||||||||-||-||-------------------------------------------|-------  3 [R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation
-||||||||--||-----------------------------------------------------  3 [N] COG1681 Archaeal flagellins
|-|||||||-|||----|-|||----||||||||||||----|||||-|------|------||--  3 [K] COG1695 Predicted transcriptional regulators
--|||||||-|-|---||||-|---|-|||-----|||----------||-----|---|||||--  3 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain)
---|--|||-|||-----||-------||-|----|||----|||--------------||-|---  3 [K] COG2002 Regulators of stationary/sporulation gene expression
|-||--||---------|---|----|-------||||----------||---------|||--|-  3 [P] COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit
-|----||----------------------------|-----------------------------  3 [M] COG2247 Putative cell wall-binding domain
-|----|||||||----|------------------------------------------------  3 [S] COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
--|-|||||-|||-----------------------------------------------------  3 [S] COG2512 Uncharacterized membrane-associated protein/domain
||||||||||||||||--------------------------------------------------  3 [R] COG2520 Predicted methyltransferase
--|-||||--||||---|--||--------|------|----------||-----|---||||---  3 [R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain
|||||||||||||||-||||-------||||-||-|||----|--||--|--|------||-|---  2 [F] COG0005 Purine nucleoside phosphorylase
|||||||||||||||---||||--------|-|-|-||----|||-|-||-|||||||-||||---  2 [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family
||||--||||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  2 [E] COG0065 3-isopropylmalate dehydratase large subunit
|||---||||||-||-||||-|----||||||-|||||----||||||||||||||--||||||--  2 [E] COG0066 3-isopropylmalate dehydratase small subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [R] COG0073 EMAP domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
---|||||---||||-||||--||--|----|||||||-||||||||-||----------------  2 [H] COG0095 Lipoate-protein ligase A
||--|-||--||-|----||-------||-------------|||||-||||-|||---||||---  2 [R] COG0121 Predicted glutamine amidotransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  2 [G] COG0148 Enolase
-||||-||-||||||---||||----|||-|-----||----||||||||--||||---|||||--  2 [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  2 [H] COG0237 Dephospho-CoA kinase
|||||||||||||||-----||----||||||||||||----|||||-|||-||||||||-|----  2 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D
||||---||----------|-------||--|||||--|||-|||-|-|||||||||||-||-|-|  2 [V] COG0286 Type I restriction-modification system methyltransferase subunit
|||||||||||||----|------|-----|||||||||||||||||-||||--------------  2 [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase
|||||||||||||---|-||-|----|||||---||||----|||||-||||---|||||||||--  2 [H] COG0303 Molybdopterin biosynthesis enzyme
||||||||||||-|---|-|-|||--|||||---||||----||||||||||-||||||||-|---  2 [P] COG0306 Phosphate/sulphate permeases
|||||||||||||---|-||----------|-----------|||-|---------|||-------  2 [O] COG0309 Hydrogenase maturation factor
|||||||||||||||-||||||--||||||||||---|-|--||||||||||||||||||||||||  2 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs
||||--|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||||  2 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase
|||||||||||-||||----------||||||---|||----|||||-||--|-------|-|---  2 [E] COG0367 Asparagine synthase (glutamine-hydrolyzing)
|-|||||||-|||||-||||-|--|-|||||--|||||----|||||-||--||||||||||||--  2 [R] COG0388 Predicted amidohydrolase
||||--||||------||||------|||||---|||-|||||||-|--|--|--|---||||---  2 [S] COG0392 Predicted integral membrane protein
---|||||--|||----|||-|--|-||||||||-|||-||||||||-||-||--|---||||---  2 [G] COG0395 ABC-type sugar transport system, permease component
|||---|||-------|||||---------|-----------|||-|--|-----|----------  2 [C] COG0426 Uncharacterized flavoproteins
|||---|||||||-|-||||-|-----||-|-----||----|||-|-||---------||-----  2 [S] COG0432 Uncharacterized conserved protein
||||||||||||-||-||||||---|||||||-|||||----|||||-||||||||||||||||--  2 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  2 [L] COG0468 RecA/RadA recombinase
|||---||||||-||-||||-|----||||||--||||----||||||||||||||--||||||||  2 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase
||||||||||||||||||||||----|||||--|||||----|||||-||||||||||||||||||  2 [D] COG0489 ATPases involved in chromosome partitioning
||||||||||||||||||||||----||||||||||||----||||||||||||||||||||||--  2 [R] COG0491 Zn-dependent hydrolases, including glyoxylases
--|-||||--|-|||||||--|--|-||||||--||||----|||||-||--|--|--||||||||  2 [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases
||-|||||-|--|||-||||||-|-|||||||||||||----||||||||||||||||||||||--  2 [F] COG0516 IMP dehydrogenase/GMP reductase
|-||--||-|-||-|--||||||||||||||||||||||||||||||-|||||--|||||||||--  2 [E] COG0520 Selenocysteine lyase
|||||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  2 [E] COG0527 Aspartokinases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0532 Translation initiation factor 2 (IF-2; GTPase)
|||||||||-|||||||-||||||-|||||||||||||||||||||||||||||||||||||||||  2 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
|-|||||||-|||||||||||-|||||||||||||||||||||||||-||||||||||||||||||  2 [I] COG0558 Phosphatidylglycerophosphate synthase
||||--||-|-------|||||----||||||||||||||||--------------||||||||||  2 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily
||||||||||||----|||||||||||---||||||||----|||||-||||||||||||||||||  2 [L] COG0608 Single-stranded DNA-specific exonuclease
-||||||||-|||----|||||----|---|||||||||---|||||-||||---|||||||||--  2 [P] COG0609 ABC-type Fe3+-siderophore transport system, permease component
-||||||||-|||----|||||----||||||||||||----|||||-||||---|||||||||--  2 [P] COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component
|||||||||-|-|---|||||||||-||||-----|||----||||||||||||||||||||||||  2 [OU] COG0616 Periplasmic serine proteases (ClpP class)
-|||--|||||-|---||||||--|||||-||||||||||||------|-----------------  2 [R] COG0618 Exopolyphosphatase-related proteins
|||||||||||||||-||-----|--||||-|-|||||----||||||||||||||--||--||--  2 [E] COG0620 Methionine synthase II (cobalamin-independent)
||||--|||||||||--|--|---|----|||||||||-||||||||-||----------------  2 [R] COG0622 Predicted phosphoesterase
||||--|||-------||||||--|||||-||||||||----||||||||||||||||||||||||  2 [R] COG0628 Predicted permease
-|||||||||||||||-|||||--------||-|-|||----||||||||||||||--|||-||--  2 [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
|||||||||||||||-|||||-----|||||-----------|||-|--|--||||---|||||--  2 [C] COG0644 Dehydrogenases (flavoproteins)
--|||||||-|||||-|-||-|||-|||||||||-|||----|||||-||||||||||||||||--  2 [E] COG0665 Glycine/D-amino acid oxidases (deaminating)
||----||--|------|------------|---|-------|||||-||-||--|---||-|---  2 [M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase
|||---||||-|----|-||----------|-----------|||-|---------|||-------  2 [C] COG0680 Ni,Fe-hydrogenase maturation factor
||||||||||||||||||||||||||||||||||||||-|--||||||||||||||||||||||||  2 [U] COG0681 Signal peptidase I
||||||||||||----||||----------|---|-||----|||||-||||||||||||||||||  2 [H] COG0720 6-pyruvoyl-tetrahydropterin synthase
-|||--|||-||------||-|---------||---------|||||-||--|--||||-|-|---  2 [R] COG0727 Predicted Fe-S-cluster oxidoreductase
|||||||||||||---||||||----|--|||--||||----|||||-||||||||||||||||--  2 [R] COG0730 Predicted permeases
|||||||||||||||--||||---------|-------------------------|||-------  2 [C] COG0731 Fe-S oxidoreductases
|||||||||||||---|-||-|----|||-----||||----|||||-||||--||||||||||--  2 [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A
|||||||||||||---||||||||||||||||||||||----|||||-||||||||||||||||||  2 [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1
----||||--|||||----|------|----|-|||||------------||----|||--|----  2 [K] COG0819 Putative transcription activator
|||-|||||||||----|||||-----||-||-----|----|||-|-||------------|---  2 [C] COG1032 Fe-S oxidoreductase
|||||||||||||||---------------------------------------------------  2 [L] COG1041 Predicted DNA modification methylase
----||||--|||||-|-|||---|-----|-|-||||----|||||-||||-|||||||||||--  2 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases
--|||||||-||||||---|||--|-|||||-||||------|||||-|-----------------  2 [KL] COG1061 DNA or RNA helicases of superfamily II
||||||||||-------|------|-----|-----||----|||||-||||--------------  2 [O] COG1067 Predicted ATP-dependent protease
|||||||||||||||||-||-|----------------------------------------|---  2 [R] COG1100 GTPase SAR1 and related small G proteins
|||||-||||-|-||||||-|------||||---|---|||||||-|--|--|---|--------|  2 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits
-||||||||--||----|||||----|---|-|||||||-|||||||-||||---|||||||||--  2 [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components
||||--|||||||----|||||--|-||||||||||||||||-||-|-|-|----|---|||----  2 [P] COG1122 ABC-type cobalt transport system, ATPase component
--||--||--||-|||||||||||--||||||||||||||||||||||||||||||||||||||||  2 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components
|||---||||-------|||----------------------|||||-------------------  2 [C] COG1142 Fe-S-cluster-containing hydrogenase components 2
|||-||||||||----||--------------------------------------||--------  2 [C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit
|||---||||-------|------------------------------------------------  2 [C] COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain
||||||||||||||||----||||||------||--------------------------------  2 [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A
|||-|||||||||---||--|------||-||||||------|||||-||||---|----------  2 [O] COG1180 Pyruvate-formate lyase-activating enzyme
-||||||||-|-|||--|------------------------------------------------  2 [J] COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
|||||||||||||------|------|||-------------|||----|-----|---|||||--  2 [R] COG1201 Lhr-like helicases
|-|-||||||||-||||-||------|---|||-||||----|||||--|-----|---|||||-|  2 [M] COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
||||||||||-|||--||||-|----|||-||---|||||--|||||-|||-||||||||||||||  2 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component
||||||||||----|-|-|||-||||----||||||||----||||---|-----|---|||||||  2 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
|||---||||-------|------------|---------------|-------------------  2 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II
|||---||||--|-----||-------||-|---|-||-----------|------------||--  2 [S] COG1300 Uncharacterized membrane protein
|-|---||||||----||||-|-----||||----|||-----------||||--|---||-||--  2 [E] COG1305 Transglutaminase-like enzymes, putative cysteine proteases
|-|||||||||||||||-||-|-----||--------------||||--|-----|----------  2 [R] COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily
|||---|||--|-----|---|||------|---|||-----------||||---|---||-|---  2 [P] COG1392 Phosphate transport regulator (distant homolog of PhoU)
|||||||||||||----------------------------------------------|||||--  2 [R] COG1407 Predicted ICC-like phosphoesterases
|-|---|||||-|||-|-||--||--||||||--|||-----|||||-||||---|---|||||--  2 [R] COG1409 Predicted phosphohydrolases
||||--||||------|-||-|--|-|---------------------||----|-||||||||--  2 [S] COG1432 Uncharacterized conserved protein
|||-|||||||------|------------|-----------------|-----------------  2 [S] COG1433 Uncharacterized conserved protein
||||--|||||||------------|----|--------------|---------|----------  2 [F] COG1437 Adenylate cyclase, class 2 (thermophilic)
-||-||||--||----|-||----|-----------------------------------------  2 [G] COG1449 Alpha-amylase/alpha-mannosidase
||||--|||-------|---||----|---|-------||--|||||-||--||||||||||||-|  2 [R] COG1451 Predicted metal-dependent hydrolase
---|||||--|||||---|-||------------|-||-----------|--|------|---|-|  2 [E] COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases
-||-|-|||||||----||-|------||-|-----||-----------|-----|---|||||-|  2 [L] COG1533 DNA repair photolyase
|||--||||-------||------------------------------------------------  2 [L] COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
||-|--||-||||----|||||----|||||-----------|||||-||-||------|||||--  2 [OU] COG1585 Membrane protein implicated in regulation of membrane protease activity
-|----|||||||||---------------------------------------------------  2 [S] COG1590 Uncharacterized conserved protein
||----|||-||------------------------------------------------------  2 [S] COG1673 Uncharacterized protein conserved in archaea
|||||||||||||--|||-|-|----|||-|------|----|||-|--|-----|----------  2 [S] COG1690 Uncharacterized conserved protein
--|---|||||||---|||||||||||||-||--||||----|||||-|||||------|||||-|  2 [R] COG1694 Predicted pyrophosphatase
||||--|||||||----|------------------------|||||-||||-||-------||--  2 [S] COG1720 Uncharacterized conserved protein
|||---||||||------------------------------------------------------  2 [R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)
-||-||||-|-||---||---|----|||-|----|-|--|||||||-||---|||---||-||--  2 [O] COG1765 Predicted redox protein, regulator of disulfide bond formation
--||--|||--------|------|-----|----|||----------|-------|||-------  2 [NT] COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation
|-|||||||---------------------------------------------------------  2 [K] COG1777 Predicted transcriptional regulators
------|||----------------------|----|-----|||||----|---|--|||-||--  2 [M] COG1794 Aspartate racemase
|||---||--|-------------------------------------------------------  2 [S] COG1817 Uncharacterized protein conserved in archaea
||----||||||||----------------------------------------------------  2 [R] COG1818 Predicted RNA-binding protein, contains THUMP domain
||----||----------------------------------------------------------  2 [S] COG1822 Predicted archaeal membrane protein
|||---||||-||-----------------------------------------------------  2 [R] COG1907 Predicted archaeal sugar kinases
-|-|--|||||||---|-------------------------------------------------  2 [R] COG1913 Predicted Zn-dependent proteases
||||||||--||----|||||-----||--|||--|||-------||--|-----||||||||---  2 [S] COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain
||||||||||--------------------------------------------------------  2 [L] COG1933 Archaeal DNA polymerase II, large subunit
|||---||||--------||----------------------------------------------  2 [C] COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit
|||-|||||||||--------------||-------------------------------------  2 [R] COG1964 Predicted Fe-S oxidoreductases
||||--|||---------------------------------------------------------  2 [S] COG1967 Predicted membrane protein
--||||-||-||----|-||-|-----||-----||||----|||||-||||---|||||||||--  2 [H] COG1977 Molybdopterin converting factor, small subunit
||||--||||------||||-|----|||-||||||||----|||||-||||||||--|---||--  2 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
||||--||-||||----|------------------------------------------------  2 [S] COG1992 Uncharacterized conserved protein
||||--||||---|||--------------------------------------------------  2 [B] COG2036 Histones H3 and H4
|||||||||||||-------------||--|--------------|---|-|---|---||-||--  2 [NU] COG2064 Flp pilus assembly protein TadC
-||-|||||||||---|--|-||||-----------|-----||||||||-|||||--||||||--  2 [U] COG2095 Multiple antibiotic transporter
||||||||||||||||--------------------------------------------------  2 [R] COG2102 Predicted ATPases of PP-loop superfamily
|-|||||||---------------------------------------------------------  2 [R] COG2150 Predicted regulator of amino acid metabolism, contains ACT domain
----|-||--|||----|---|---------|||||||----|||||-|----------|------  2 [G] COG2182 Maltose-binding periplasmic proteins/domains
||||||||||||||---|||||----|||-|-||||||----|||||-||-||--|--|||||--|  2 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold
--|||||||-|||||----|----|||--------------------------||||||-------  2 [R] COG2236 Predicted phosphoribosyltransferases
---|--||-------------------||-------------------------------------  2 [S] COG2253 Uncharacterized conserved protein
------||-----||-||||||||--|||-||||||||----|||||-||||||||--||||||--  2 [J] COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase
---|---||-|-----|-||-------|--------------------------------------  2 [R] COG2402 Predicted nucleic acid-binding protein, contains PIN domain
|-----||-||-|-----|-----------------------------------------------  2 [R] COG2403 Predicted GTPase
------|||||-|-----------------------------------------------------  2 [S] COG2411 Uncharacterized conserved protein
|||----||-|-----|-----------------|-||----------------------------  2 [S] COG2445 Uncharacterized conserved protein
--||--|||-|||-----------------------------------------------------  2 [R] COG2522 Predicted transcriptional regulator
----||||--||--------------|---||||||||----|||||-|----------||--|--  2 [G] COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase
--|----|------------||----|-----------|-------------------|-------  2 [K] COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen
-|-----||---|-----------------------------------------------------  2 [S] COG2880 Uncharacterized protein conserved in archaea
|||---||||--------||----------------------------------------------  2 [C] COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit
|||--|||-|-|---------------||-------------|||-|-------------------  2 [C] COG3260 Ni,Fe-hydrogenase III small subunit
|||--|||-|-|---------------|--------------|||-|-------------------  2 [C] COG3261 Ni,Fe-hydrogenase III large subunit
--|---||-------------------|--------------|||-|-------------------  2 [C] COG3262 Ni,Fe-hydrogenase III component G
|-||--||||--|-----------------------------------------------------  2 [S] COG3273 Uncharacterized conserved protein
----||||--|||-----------------------------------------------------  2 [S] COG3371 Predicted membrane protein
-||||||||-|||------|-------||--------------||||-----|--|---||-||--  2 [K] COG3609 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain
------||-|---------------------------|----------------------------  2 [S] COG4043 Uncharacterized conserved protein
|-|-|||||-||------------------|------------------------|------||--  2 [C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits
-||---||----------------------------------------------------------  2 [G] COG4809 Archaeal ADP-dependent phosphofructokinase/glucokinase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase
||-|||-|-||-|||-|-|||------|||-----|-|----------------------------  1 [P] COG0003 Oxyanion-translocating ATPase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||---|||||||  1 [J] COG0009 Putative translation factor (SUA5)
||-||||||||--|--|||-------|||-|--||-||----------------------------  1 [S] COG0011 Uncharacterized conserved protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0012 Predicted GTPase, probable translation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0013 Alanyl-tRNA synthetase
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0015 Adenylosuccinate lyase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0018 Arginyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [I] COG0020 Undecaprenyl pyrophosphate synthase
|||||||||||||||---||----------------------|||||-||||--------------  1 [J] COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [J] COG0024 Methionine aminopeptidase
||||||-|||---|||--||-|----|||--|-||||-----|||||-||-||------|--|---  1 [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
-|----||---|------||------|||-------|-----|||||-||-|--------------  1 [F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)
|||-||-||||||||-||||-|----||||||-|||||----||||||||||||||--||||||--  1 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
---|--||---|----|-|||------||||----|||----|||||-||--||||---||-||--  1 [H] COG0029 Aspartate oxidase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0030 Dimethyladenosine transferase (rRNA methylation)
--||||-|--|||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [E] COG0031 Cysteine synthase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase
|--|---|--|||||-||||||--|-|||-|||||||||||||||||-||||-|||--||||||--  1 [F] COG0035 Uracil phosphoribosyltransferase
-|||||||||-||||-|-||||----|||-||||---|----|||||-|-||-|||---|-|||--  1 [P] COG0038 Chloride channel protein EriC
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases
|||||||||||||||-||||||----||||||||||||----|||-|--|--|--|||||||||--  1 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0048 Ribosomal protein S12
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0049 Ribosomal protein S7
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0051 Ribosomal protein S10
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0052 Ribosomal protein S2
||||---||||||||-||||||---||||-||||||||----|||||-||-|---|--||||||||  1 [P] COG0053 Predicted Co/Zn/Cd cation transporters
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||--  1 [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
-||---||--||-|--|-||||||--|||-||||--||----|||||-||||-------||-|---  1 [G] COG0058 Glucan phosphorylase
|||----|||||-|--||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EH] COG0059 Ketol-acid reductoisomerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0060 Isoleucyl-tRNA synthetase
|||||||||||||||||||||---|||||||||||||||-||||||||||||||||||||||||||  1 [G] COG0061 Predicted sugar kinase
|||||||||||||||-||||-|----|||||-----------|||||-||--|--|||||||||--  1 [S] COG0062 Uncharacterized conserved protein
||||||||||||||||||||-|----||||||--|||-----|||||-||--||||||||||||--  1 [G] COG0063 Predicted sugar kinase
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0068 Hydrogenase maturation factor
|||||||||||||||-||||-|-----||||---|-||----||||||||--|--|---|||||||  1 [O] COG0071 Molecular chaperone (small heat shock protein)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit
||||||||||||||--||||-|--------||--|-||--------|-||------||-||-||--  1 [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase
||||--||||--||----||-------||--|---|-|----||||--|-|---------|||---  1 [E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins
|||||||||||||||-||||-|---|||||||||||||--|-||||||||||||||--||||||--  1 [E] COG0078 Ornithine carbamoyltransferase
|||||||||||||||-||||||----||||||--||||----||||||||||||||--||||||--  1 [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0080 Ribosomal protein L11
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0081 Ribosomal protein L1
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0082 Chorismate synthase
-|-|||||-||||||-||||-|----||||||-|||||----|||||||-|||---|||-------  1 [E] COG0083 Homoserine kinase
|||---||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0084 Mg-dependent DNase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0087 Ribosomal protein L3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0088 Ribosomal protein L4
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0089 Ribosomal protein L23
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0090 Ribosomal protein L2
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0091 Ribosomal protein L22
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0092 Ribosomal protein S3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0093 Ribosomal protein L14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0094 Ribosomal protein L5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0096 Ribosomal protein S8
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0097 Ribosomal protein L6P/L9E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0098 Ribosomal protein S5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0099 Ribosomal protein S13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0100 Ribosomal protein S11
|||||||||||--||||||||||||||||||||||||||-||||||||||||||||||||||||||  1 [J] COG0101 Pseudouridylate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0102 Ribosomal protein L13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0103 Ribosomal protein S9
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0104 Adenylosuccinate synthase
|||||||||||||||||-||-||||||||||--|||||----|||||-||||||||||||||||||  1 [F] COG0105 Nucleoside diphosphate kinase
||||---|-||--||--|||-|||--||||||||||||----|||-|-||-|-|||--||||||-|  1 [R] COG0110 Acetyltransferase (isoleucine patch superfamily)
|||||||||||||||-||||-|----||||||--||||----|||||-|||||--|||||||||--  1 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
||||||||||||||||||||-|||||||||||||||||-|||||||||||||||||||||||||||  1 [E] COG0112 Glycine/serine hydroxymethyltransferase
-|----|||||-|-----|-||--------||||||||----||||||||||||||----------  1 [L] COG0116 Predicted N6-adenine-specific DNA methylase
||||||||||||||||--||-|||||----||||||------||||||||||||||---|||||--  1 [G] COG0120 Ribose 5-phosphate isomerase
|-||--|||---||||--|--|-----||-|-----||-|--|||||-||--|--|---|||||--  1 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase
||||--|||||||||||-||-|------------|-||----------||---|||---|||||--  1 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0124 Histidyl-tRNA synthetase
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [F] COG0125 Thymidylate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0126 3-phosphoglycerate kinase
||||||||||||||||||||||||||||||||||||||----|||||-||||||||--||||||--  1 [F] COG0127 Xanthosine triphosphate pyrophosphatase
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase
|||----||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase
||||||||||||||||||||||||||||||||||||||||--||||||||||||||--||||||||  1 [J] COG0130 Pseudouridine synthase
||||---|||---||-|||||||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0133 Tryptophan synthase beta chain
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0134 Indole-3-glycerol phosphate synthase
||||||-||||||||-||||-||---|---||-|||||----||||||||||||||||||||||--  1 [E] COG0135 Phosphoribosylanthranilate isomerase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0136 Aspartate-semialdehyde dehydrogenase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [H] COG0142 Geranylgeranyl pyrophosphate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0143 Methionyl-tRNA synthetase
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0149 Triosephosphate isomerase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0150 Phosphoribosylaminoimidazole (AIR) synthetase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||||||||||--  1 [F] COG0151 Phosphoribosylamine-glycine ligase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||||  1 [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
-|--||||-----||||-||||||---|||----|-||----|||||-||||||||||||||||||  1 [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes
||||--||||||-|--|||||-----|||||-||-|||----|||||-||||||||||-||-||--  1 [H] COG0157 Nicotinate-nucleotide pyrophosphorylase
||||||-||||||||-||||-||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0159 Tryptophan synthase alpha chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0162 Tyrosyl-tRNA synthetase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase
||||||||||||||||||||||||-|||||||||||||----|||||-||||||||||||||||||  1 [L] COG0164 Ribonuclease HII
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0167 Dihydroorotate dehydrogenase
||||--||||--|||-||||||--||------||||||-||||||||-||||-||---||||----  1 [P] COG0168 Trk-type K+ transport systems, membrane components
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0169 Shikimate 5-dehydrogenase
|||-|||||||--||||-||----||--------------------------------------||  1 [I] COG0170 Dolichol kinase
|||||||||||||||-||||||--||||||||||||||||||||||||||--||||||||||||--  1 [H] COG0171 NAD synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0172 Seryl-tRNA synthetase
|||||||||||||||-||||-|----||||-|||||||----|||||-||||||||||||||||||  1 [E] COG0174 Glutamine synthetase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [L] COG0177 Predicted EndoIII-related endonuclease
|||||||||||||||---||-|----||||----||||----|||||-||-|-|||--||||||--  1 [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0180 Tryptophanyl-tRNA synthetase
|||-|||||||||||-|||||---------------|------------|--|-------|-|---  1 [J] COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
||||||||||||||||--|-||---||||||||-||||----|||||-|||----|||-|||||||  1 [I] COG0183 Acetyl-CoA acetyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0184 Ribosomal protein S15P/S13E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0185 Ribosomal protein S19
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0186 Ribosomal protein S17
-|||--|||-|||-----||-|---------------|--||||||||||||||||---|||||--  1 [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0197 Ribosomal protein L16/L10E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0198 Ribosomal protein L24
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0199 Ribosomal protein S14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0200 Ribosomal protein L15
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0201 Preprotein translocase subunit SecY
||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit
-||---|||--------|---|-----||-||-||||||||||||-|-|------|---||-|---  1 [F] COG0213 Thymidine phosphorylase
|||||||||||||||--|--||----|||||--|||||------------||--------------  1 [H] COG0214 Pyridoxine biosynthesis enzyme
--|||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0215 Cysteinyl-tRNA synthetase
-|||--||||---|--||--|---------||||||||||||||||||||||||||||||||||||  1 [R] COG0218 Predicted GTPase
|-||||||-|-||||||-||||||--|||||----|-|||||||||||||||||||||||||||||  1 [C] COG0221 Inorganic pyrophosphatase
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG0226 ABC-type phosphate transport system, periplasmic component
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)
||||-||||||-|||-||-||------||||-||-|||-||-|||||-|||||--|||--||||||  1 [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
-|||--||-|---||-||||-|----|||-|--|||||----|||||-||||||||||||||||--  1 [D] COG0239 Integral membrane protein possibly involved in chromosome condensation
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0244 Ribosomal protein L10
|||||||||||||-|-||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0250 Transcription antiterminator
---|--||--|||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [J] COG0251 Putative translation initiation inhibitor, yjgF family
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0255 Ribosomal protein L29
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0256 Ribosomal protein L18
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI)
|||---|||||||-----------------|-|||-|--||-|||-|-|-||--------------  1 [G] COG0269 3-hexulose-6-phosphate synthase and related proteins
||----||-||||-|---||------|---|-||--||||--|||-|-|-|-||||||--|-||--  1 [L] COG0270 Site-specific DNA methylase
--|||||||-|||||--|||-|----|||-|||-||||----|||||-||||||||--||||||||  1 [C] COG0281 Malic enzyme
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0284 Orotidine-5'-phosphate decarboxylase
|||||||||||||||-||||||||--||||||||||||----|||||-||||||||||||||||-|  1 [H] COG0294 Dihydropteroate synthase and related enzymes
-|----||--||--|-||||||||------||-|--||----|||||-||||---|---||-|---  1 [G] COG0297 Glycogen synthase
|||---||||--------||----------|-----------|||-|---|-----|||-------  1 [O] COG0298 Hydrogenase maturation factor
--|----|---|-|||---||-----||||||||||||-----------|-|---|---||-||--  1 [R] COG0300 Short-chain dehydrogenases of various substrate specificities
|||||||||||||||--|---|----|||||--|||||------------||--------------  1 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis
|||||||||-|||---|-||-|----|||-----||||----|||||-||||---|||||||||--  1 [H] COG0314 Molybdopterin converting factor, large subunit
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [H] COG0315 Molybdenum cofactor biosynthesis enzyme
||||--||||---|||---|||||||||-|||||||||||--||||||||||-||||||-------  1 [S] COG0327 Uncharacterized conserved protein
|||||||||||||---|||||-||--||||||||||||----||||||||||||||||||||||||  1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase
--|||||||-|||||--|||||||--|---|--|||||----|||||--|||-|||||--||-|--  1 [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase
----||-|--|||||--|||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0337 3-dehydroquinate synthetase
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0341 Preprotein translocase subunit SecF
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0342 Preprotein translocase subunit SecD
|||||||||||||-||||||||||-||---||||||||----||||||||||||||||||||||||  1 [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase
|-||--|||--||||---||||----||||||||||||----|||||-||||||||--||||||--  1 [E] COG0346 Lactoylglutathione lyase and related lyases
||||||||||||||--||-||-|||-||||||-|||||-|--|||||-||||||||||||||||-|  1 [L] COG0350 Methylated DNA-protein cysteine methyltransferase
|||||||||||||||-||-|||--|-||||||||||||----|||||-||||||||||||||||--  1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
--|-|||||----||-|-||||----||||||-|||||----|||||-||||||||||||||||--  1 [H] COG0352 Thiamine monophosphate synthase
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0358 DNA primase (bacterial type)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0361 Translation initiation factor 1 (IF-1)
|||||||||||||-----||||----|||-|----|-|----|||-|-||-----|---||||---  1 [H] COG0368 Cobalamin-5-phosphate synthase
|||---|||||-----||||-|--------||--||------|||||-||--|--||||----|--  1 [P] COG0370 Fe2+ transport system protein B
|||||||||||||-|--|||----------||||-|||----|||||-------------|-----  1 [C] COG0371 Glycerol dehydrogenase and related enzymes
|||---||||------|-||-|--------------------|||-|---------|||-------  1 [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)
--|||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases
||||--||||||----|||||-----|||||----|||----|||||-||--||||||-||-||--  1 [H] COG0379 Quinolinate synthase
||-|--||---------|||-|--------||-||||-----|||||-||-|-|||--|-----||  1 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase
|||||||||||||||-|-||-|||--|||||------|----|||||-||-|||||||||||||||  1 [H] COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases
|||||||||--|-----|||-------|||-|---|-|----|||-|-|--|-----------|--  1 [S] COG0393 Uncharacterized conserved protein
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
||-----|-||-----||||----|-|||-|--|--|-----|||||-||-|-||||||-||||--  1 [M] COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis
|||||||||||||||-||||-|----|---|--|---|----|||||--||||--|||||||||--  1 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
---|||||---||||-||||-|-----|||----||||----|||||--|--|-||---|||||--  1 [E] COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain
---|||||---||||-||||-|-----|||----||||----|||||--|--||||---|||||--  1 [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase)
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0409 Hydrogenase maturation factor
---|--||--|||||-||||-|----|||||---||||----||||||||--||||||||||||--  1 [H] COG0413 Ketopantoate hydroxymethyltransferase
||||||||||||||||---|----------------------|||||-||----------------  1 [L] COG0417 DNA polymerase elongation subunit (family B)
||||||||||||||||||||||--||----||--|||-----|||||-||----------------  1 [L] COG0419 ATPase involved in DNA repair
||||||||||||||||||||||--||||||||--||||----|||||-||----------|-----  1 [L] COG0420 DNA repair exonuclease
-|--|||||||||||-||---|----|---|--|--||----||||||-|--||||||----|---  1 [E] COG0421 Spermidine synthase
||||---|||||----||||||----|||||-----||----|||||-||--||||--|||-||--  1 [H] COG0422 Thiamine biosynthesis protein ThiC
||||||||||||||||-----|--|||||||---|---||||------------------------  1 [J] COG0423 Glycyl-tRNA synthetase (class II)
--|---||-----||-||||||||--|||||-----||----|||||-||-|||||||||||||||  1 [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation
||||--||--||||||||-|-|---||||------|------|||-|--|---|||--|-|-----  1 [P] COG0428 Predicted divalent heavy-metal cations transporter
||||--|||||||||||--|----------------------|||-|--|-----|----------  1 [A] COG0430 RNA 3'-terminal phosphate cyclase
|||||||||||||---||||-|-----||---|----|----||||---|-|---|---|||||--  1 [R] COG0433 Predicted ATPase
-|-|--|||||-|-----||----------------------|---|------------|--|---  1 [R] COG0434 Predicted TIM-barrel enzyme
--||---||-|||---|-------------------------|||||-||||---|--|-|-|---  1 [C] COG0437 Fe-S-cluster-containing hydrogenase components 1
|||---||||--|||-||||-|----||||||-|||||----||||||||||-|||--||||||--  1 [E] COG0440 Acetolactate synthase, small (regulatory) subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0441 Threonyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0442 Prolyl-tRNA synthetase
||||||||-||||||||||||||||-||||||||||||----||||||||||||||||||||||--  1 [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
|||-|||||-|||||||||||||||--|||-||-||||----||||||||-||--|||||||||||  1 [O] COG0450 Peroxiredoxin
|||||||||||||||-||||||---|||||||||||||----|||||-||||||||||||||||--  1 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase
||||||||||||||||||||||----|||||||||||||---|||||-||||||||--||||||--  1 [R] COG0456 Acetyltransferases
||||||||||||||||||||||||||||||||||||||--||||||||||||||||||||||||||  1 [O] COG0459 Chaperonin GroEL (HSP60 family)
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0460 Homoserine dehydrogenase
|||||||||||||||-||||||-|--||||||||||||----||||||||||||||||||||||--  1 [F] COG0461 Orotate phosphoribosyltransferase
|||||||||||||||-||||||--||||||||||||||||||||||||||||||||||||||||-|  1 [FE] COG0462 Phosphoribosylpyrophosphate synthetase
-|||||||--||||||-|||||||-|||||||||||||||||||||||||||||||--||||||--  1 [G] COG0469 Pyruvate kinase
||-|--||-||--||-|-|--|||--|---|||||-||----|||||-||||||||||||||----  1 [P] COG0471 Di- and tricarboxylate transporters
||----||-|||-||-||||||||||||||||||||||----|||||||||||||||||||||-||  1 [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
|-|||||||-|||||||-||||----|||||--|||||----|||||-||||||||||||||||--  1 [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
-|||--||||||||||--------------------------------------------------  1 [T] COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0480 Translation elongation factors (GTPases)
||||--||||||||--||||-|---|||||-|||||||----|-||||||||||||--||||||||  1 [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
||||||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0492 Thioredoxin reductase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0495 Leucyl-tRNA synthetase
|||||||||||||||-||||------||||-------------------|--|--|---|||||--  1 [H] COG0499 S-adenosylhomocysteine hydrolase
||||--||-||||||--|||||--|||||-||||||||||||||||||||||-||||||||||---  1 [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
||||||||||||||||||||-|||||||||||||||||||--||||||||||||||||||||||||  1 [F] COG0504 CTP synthase (UTP-ammonia lyase)
---|||||---||||-||||-|||---|||--|-||||-|--|||||-||--||||---|||||--  1 [E] COG0509 Glycine cleavage system H protein (lipoate-binding)
|||---|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||--  1 [I] COG0511 Biotin carboxyl carrier protein
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0518 GMP synthase - Glutamine amidotransferase domain
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0519 GMP synthase, PP-ATPase domain/subunit
|||||||||||||---|--|-|----|||||---||||----|||||-||||---|||||||||--  1 [H] COG0521 Molybdopterin biosynthesis enzymes
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0522 Ribosomal protein S4 and related proteins
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0525 Valyl-tRNA synthetase
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0528 Uridylate kinase
-------||---|||-|-|--|-----||-|-----||----||||||||--|--|--|-||||--  1 [P] COG0529 Adenylylsulfate kinase and related kinases
||||||||||||-||-|||-----||-----------|----|||||-|--|--------|-----  1 [P] COG0530 Ca2+/Na+ antiporter
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0533 Metal-dependent proteases with possible chaperone activity
|||||||||||||||-||||||----||||||||||||----||||||||--||||||||||||--  1 [F] COG0540 Aspartate carbamoyltransferase, catalytic chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0541 Signal recognition particle GTPase
|-||--|||----|--|-||-|--|||||-|||||||||---|||||-||||||||||||||||--  1 [R] COG0546 Predicted phosphatases
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0547 Anthranilate phosphoribosyltransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||-|  1 [E] COG0548 Acetylglutamate kinase
---|||||--|-|-----|------------||||-----|-|||-|--||---------|-----  1 [E] COG0549 Carbamate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0550 Topoisomerase IA
|||||||||--------|--|-|||-----|||||||||-|||||||||||||||||||-------  1 [L] COG0551 Zn-finger domain associated with topoisomerase type I
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0552 Signal recognition particle GTPase
--||-||||--|||||-|||||||--|||-||||-|||--|||||||-|||||-------|-----  1 [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family
---|||-||--|||--||||||---|||||||||||||-||||||||-|||||--|---|||||--  1 [C] COG0554 Glycerol kinase
||||||||||||------||-|-----||-|------|----|||||-||||||||---|||||--  1 [O] COG0555 ABC-type sulfate transport system, permease component
|||||||||||-|||-----|--|--||||||----------|||||-||||||||||||||||--  1 [E] COG0560 Phosphoserine phosphatase
|-||||||||||||||-||||||||||||||||||||||||||||||||-||-|||---||-|---  1 [R] COG0561 Predicted hydrolases of the HAD superfamily
--||--|||----|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0563 Adenylate kinase and related kinases
||||--|||||-|---||||||--||-||---||||||-||||||||-||||-||---||||----  1 [P] COG0569 K+ transport systems, NAD-binding component
||||---||||||---||||-|---||||||||||||||-|||||||-|-|||--|--||||||--  1 [P] COG0573 ABC-type phosphate transport system, permease component
|||||||||||||---||||||--|-|||||--|-||-----|||||-||--||||||||||||||  1 [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [I] COG0575 CDP-diglyceride synthetase
----|--||---|----||||-----|||-|---|--|-||||||-|-||--||||||||||||--  1 [R] COG0579 Predicted dehydrogenase
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG0581 ABC-type phosphate transport system, permease component
|||||||||--||---||||||||--||||||||||||||--|||||-||||||||||||||||||  1 [L] COG0582 Integrase
---|||-|--|-||||-|-|||--|-||||||||||||-||||||||-||||---|---|||||--  1 [C] COG0584 Glycerophosphoryl diester phosphodiesterase
|||||||||||||||||----|--------------------|||||-||||----|||-------  1 [S] COG0585 Uncharacterized conserved protein
|||||||||||||-|-|-||-|----||||-|||||||----|||||-||||-|||---|||||||  1 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
||||||||||||----|-|||---------||||||||----|||||-||||||||||||||||||  1 [O] COG0602 Organic radical activating enzymes
|||||||||||||---|-||----------|---|-||----|||||-||||||||||||||||||  1 [R] COG0603 Predicted PP-loop superfamily ATPase
||||---||----------|-----------||-||--|||-------||||||--|||-||-|-|  1 [V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
|||||||||||||---|-||------||||------||----||||||||||||||--|----|--  1 [H] COG0611 Thiamine monophosphate kinase
|||||||||||||||||--------------|--|||----------------------------|  1 [MI] COG0615 Cytidylyltransferase
||||--||||-||----|||||----||||||||||||||||-||-|---|--------|||----  1 [P] COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
|||||||||||||---||||||-||-|||||---|-||----||||||||||||||||||||||||  1 [J] COG0621 2-methylthioadenine synthetase
--||||||--|||||--|--||----||||||||||||----|||||-||||||||||||||||--  1 [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases
||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K
--||--|||--------|||-|--||----|----|||----|||||-||--|--||||||-||--  1 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases
---|--|||--||||-||--|-----|||--|||||||----|||||--|--------||||||||  1 [G] COG0647 Predicted sugar phosphatases of the HAD superfamily
||||||||--||||||||----||---||||---|||||||||||||||-----------------  1 [L] COG0648 Endonuclease IV
--|||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7
---|||||--||||||-||-------||||||||||||----|||||--|-----|---|||||--  1 [R] COG0656 Aldo/keto reductases, related to diketogulonate reductase
|||---||||------|||||------||-------||----|||||-||--||||||-|||||--  1 [G] COG0662 Mannose-6-phosphate isomerase
|||-||||-|-|----|-||-|----|||-|-----||----|||-|-||--||||--||||||||  1 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily
|||||||||||||-||||||||--|||||-||||||||----||||||||--||||||||||||||  1 [M] COG0668 Small-conductance mechanosensitive channel
||||--||-|-|-||||-||||--|-||||||||||||----|||||-|||||--|||-|||||||  1 [I] COG0671 Membrane-associated phospholipid phosphatase
--|-||||--|||||-||||-|----|---||-|||||----||||||||||||||--||||||--  1 [E] COG0685 5,10-methylenetetrahydrofolate reductase
|---|||||||||||||--|||----||||-----|||----|||||-||||||||---|||||||  1 [J] COG0689 RNase PH
-||||||||||||||-|-||||--||-||-|--|||||-||||||||-||-||--|--||||||--  1 [R] COG0693 Putative intracellular protease/amidase
-||||-|||||||||-||||-|--|-||||||||||||----|||||-|||||--|--||||||--  1 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
||||||-|||||-||-|-----||-------||||||-----|||-|------||-----------  1 [E] COG0710 3-dehydroquinate dehydratase
|||||||||||||---|-||--||--|||||------|----||||||-|||||||||||||||||  1 [F] COG0717 Deoxycytidine deaminase
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [P] COG0725 ABC-type molybdate transport system, periplasmic component
--|--|-|-|---|||-|||||||---|||||||||||----|||||-||--|--|||-|||||--  1 [G] COG0726 Predicted xylanase/chitin deacetylase
||||-|-||----------|-------||--|||||--|||||||-|-|||||---|||-||-|-|  1 [V] COG0732 Restriction endonuclease S subunits
-|||--|||-------|---|-|||-|------|||||----------|-||-||-|||-------  1 [R] COG0733 Na+-dependent transporters of the SNF family
|-||--|||----|||-|||-|--||-||-|----|||----|||||-|||||--|||||||||--  1 [T] COG0784 FOG: CheY-like receiver
|-|---|||-|-|---||||||--|-||||--||--||------------||----||-||||---  1 [O] COG0785 Cytochrome c biogenesis protein
|||---|||||||---|---|-||------|---|||-----|||||-||||||||||||||||||  1 [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation
|-||--|||-|-|---|||||||||-||||||||||||-------||--|||-||---|||-|-||  1 [P] COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
--||--|||--------|||----||----|----|||----|||||-||--|--||||||-||--  1 [NT] COG0835 Chemotaxis signal transduction protein
--||--|||-------||||-|--------|-----------|||||-||--|---||-|||||-|  1 [M] COG0836 Mannose-1-phosphate guanylyltransferase
------||||||||||||--||----|||||-|-||||-|--|||||-||-|---||||----|--  1 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family
--|||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit
||||--|||||||-----------------|----|||----|||-|---------||---|-|--  1 [K] COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain
---|||||---||||-||||-|-----|||----||||----|||||--|--|-||---|||||--  1 [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain
-|||---||--|----|-||------|||---|---||----|||||-||-||--|--||||||||  1 [M] COG1004 Predicted UDP-glucose 6-dehydrogenase
--||||-||-|||---|-||-|----|||-----||||----||||||||--||||||||||||||  1 [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit
|||||||||||--||---------------------------------------------------  1 [R] COG1019 Predicted nucleotidyltransferase
--|-|||||-|-|---|-----------------|-||-----------|-----|----|-|---  1 [O] COG1030 Membrane-bound serine protease (ClpP class)
-|||--|||||-|----|------------------------------------------------  1 [C] COG1031 Uncharacterized Fe-S oxidoreductase
-|||--||||-------|------||-----------|-----------|--------|-------  1 [R] COG1033 Predicted exporters of the RND superfamily
|||||||||||||-------||--|-----------------|||||-|||||||||||-------  1 [O] COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
|||---|||||||---|-||-|----||||||-|-|||-------|--||-----|---|||||-|  1 [F] COG1051 ADP-ribose pyrophosphatase
----|||||-|||----||||-||---|||----||||----||||--||---|||--||--|---  1 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases
|||||||||-|||-----|--|-----||--|----------|||||---||---|----------  1 [H] COG1056 Nicotinamide mononucleotide adenylyltransferase
---||||||-||||---|||||-----||||-||||||----|||||-|----|||---|||||--  1 [R] COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA
--|||||||--||||--|-|-|-----||-||||||||--|-|||||-|||-||||---||-||--  1 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
--||---||---||||-|-|||||--|||-|||--|||----|||||-||-||--|---|||||--  1 [R] COG1073 Hydrolases of the alpha/beta superfamily
|||||||||||||--|||--|----------||||||||-||------------------------  1 [R] COG1078 HD superfamily phosphohydrolases
---|--|||-|-|----|-|-|--||----||||-||-||||-------|-----|---||||---  1 [R] COG1079 Uncharacterized ABC-type transport system, permease component
||||||||||||||||--------------------------------------------------  1 [R] COG1084 Predicted GTPase
|-|--||||--||-|---||||----|||||||---||----|||||--|||||||---||-||--  1 [M] COG1088 dTDP-D-glucose 4,6-dehydratase
|-||-||||--||---|-||||----|||||||---||----|---|--|--||||---||-||||  1 [M] COG1091 dTDP-4-dehydrorhamnose reductase
-|----||-|--|---||--||||-------||||||-----||||||||||||||---||||---  1 [R] COG1092 Predicted SAM-dependent methyltransferases
||||||||||||||||--------------------------------------------------  1 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)
||||||||||||||||--------------------------------------------------  1 [R] COG1094 Predicted RNA-binding protein (contains KH domains)
||||||||||||||||--------------------------------------------------  1 [K] COG1095 DNA-directed RNA polymerase, subunit E'
|-|-|||||||||||---------------------------------------------------  1 [J] COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain)
|-|-||||||||||||--------------------------------------------------  1 [J] COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)
|||||||||||||-----------||----------------------------------------  1 [F] COG1102 Cytidylate kinase
-|----||---|-------||-----------------------------------||--------  1 [R] COG1106 Predicted ATPases
||||--||||--------------------------------------------------------  1 [L] COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain
|-||--|||-|-|---|||||||||-||-|||||||||----||||||||||-||---|||||-||  1 [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
-|----|||||||---||------------------------------------------------  1 [L] COG1110 Reverse gyrase
||||||||||---||---------------------------------------------------  1 [L] COG1111 ERCC4-like helicases
--|---||------------|||||-|-----|||-||----|||-|-||||-||-|||-||----  1 [E] COG1115 Na+/alanine symporter
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG1117 ABC-type phosphate transport system, ATPase component
|-||--|||-|||---|||||||||-|--|||||||||----||||||||||-||---|||||-||  1 [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component
|--|---||-|-|----|||-------||-||||||||----------------------------  1 [C] COG1141 Ferredoxin
||||||-|||||-----|||-|----|||||-----------|||-|-||--|--|||||||||||  1 [C] COG1146 Ferredoxin
|||----|||-------|--|---------|-----------|||||-------------------  1 [C] COG1151 6Fe-6S prismane cluster-containing protein
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B
-||---||-|||||||-||||----|----||||||||||||------|----||-----------  1 [R] COG1161 Predicted GTPases
||||||||||||||||--------------------------------------------------  1 [R] COG1163 Predicted GTPase
----||||--|||||--|-|||----|||||-||||||----|||||-||-|---|---|||||--  1 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs
---|--||--|-|-----||||--|-|------|---|----|||||-||||-|||--|||||---  1 [P] COG1178 ABC-type Fe3+ transport system, permease component
||-|-|||-|||----|-||-||||||||||----|||--|||||||-||--||||||||||||||  1 [D] COG1192 ATPases involved in chromosome partitioning
|-||--||--------||||||---|----||||||||------------------|||-------  1 [L] COG1193 Mismatch repair ATPase (MutS family)
-||||||||----|||||||||--||||||||||||||||||-------|--|||----|||||--  1 [D] COG1196 Chromosome segregation ATPases
||||||||--|||||||-|||-----|||-||||||||----|||||-||||||||-------|--  1 [KL] COG1199 Rad3-related DNA helicases
||||--||-|--------------------------------------------------------  1 [R] COG1202 Superfamily II helicase, archaea-specific
|||---|||-|||---||--|-----------|----|----|||||----|--------------  1 [R] COG1203 Predicted helicases
|||||||||||||||||-------------------------|----------------||-----  1 [R] COG1204 Superfamily II helicase
|||---||||||-||----|-|----|||-------||-----||---------------|-----  1 [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
|-|||||||--||----|||-|----|||||||---||----|||||--|--||||---||-||--  1 [M] COG1209 dTDP-glucose pyrophosphorylase
|||----|---|----|--||----|||||||||||||--|||||||-||||||||||||||||--  1 [M] COG1210 UDP-glucose pyrophosphorylase
|-----|||---|---|---|----------------------------|--------|----|--  1 [M] COG1213 Predicted sugar nucleotidyltransferases
|-|--||||---|-----||-|----|||||-----------|---|--||-|--|---||-||--  1 [R] COG1216 Predicted glycosyltransferases
||||--||||-|||||--------------------------------------------------  1 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit
------||||||||||--------------------------------------------------  1 [K] COG1224 DNA helicase TIP49, TBP-interacting protein
||||||||||||||||-|||-|||||||||||||||||----|||-|----|---|------||--  1 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
||||||||||||-|||-|--|---------|-----------------------------------  1 [KB] COG1243 Histone acetyltransferase
||||||||||--------------------|-----------------------------------  1 [R] COG1244 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
-||-|||||-|||----|-|-|---|--|-||||||||----|||||-||-|---|----|-|---  1 [C] COG1254 Acylphosphatases
||-|--|||---------------------------------------------------------  1 [S] COG1255 Uncharacterized protein conserved in archaea
||||||||||||||||---------|-----|||||------------|-----------------  1 [I] COG1257 Hydroxymethylglutaryl-CoA reductase
|||||||||||||--|--------------------------------------------------  1 [J] COG1258 Predicted pseudouridylate synthase
|-|---|||-||||--||--------||||------------------------------|-----  1 [I] COG1260 Myo-inositol-1-phosphate synthase
|||---||-||-|---|---|-----------|--|||----|||||-||||-||||||-----||  1 [I] COG1267 Phosphatidylglycerophosphatase A and related proteins
|-||--|||--------||||||-|-|---||||||||---------------------||||-||  1 [R] COG1268 Uncharacterized conserved protein
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I
|||||||||||||-----||||-----||-|----|-|--------|-||-----|---||||---  1 [H] COG1270 Cobalamin biosynthesis protein CobD/CbiB
----||||---|----------|||-||||-------------------------|----------  1 [C] COG1274 Phosphoenolpyruvate carboxykinase (GTP)
-|--|-|||----||-----------|||--||||-------|||-|-|-||-|------------  1 [P] COG1275 Tellurite resistance protein and related permeases
||||||||||||||||-|||||---|----||||||||------------------|||-------  1 [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP
--||--||----|---|--||||||||||-|---|-||----|||||-||--|--|--|||-||||  1 [C] COG1301 Na+/H+-dicarboxylate symporters
||||||||||-||-----------------------------------------------------  1 [S] COG1303 Uncharacterized protein conserved in archaea
|||||||||||||||---||-|--||||||-||||||-----|||||-||||-||----|||||||  1 [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
|||||||||||-||||--------------------------------------------------  1 [K] COG1308 Transcription factor homologous to NACalpha-BTF3
|-||---||--|----||||||----|||||||||||||---|||||-||||||||--||||||--  1 [K] COG1309 Transcriptional regulator
||||||||||---|||--------------------------------------------------  1 [L] COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
|||---|||||-|---||------------|-----------------------------------  1 [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins
-|----|||||-|---||------------------------------------------------  1 [K] COG1318 Predicted transcriptional regulators
|||||||||||||----|---||||-||||||||||||----|||-|-----|---------|---  1 [K] COG1321 Mn-dependent transcriptional regulator
|-|-|||||||-|--|||-|-|-|------------------|||||-----|--|--------||  1 [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations
||||--|||||||-----------------------------------------------------  1 [J] COG1325 Predicted exosome subunit
||||--||||--------------------------------------------------------  1 [R] COG1326 Uncharacterized archaeal Zn-finger protein
|||---||-|-------|--|---------||||||------|||||-||||---|----------  1 [F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase
--|||||||||||||-||-|-|--|||||-||||||||----|||||-||--||||--||||||--  1 [Q] COG1335 Amidases related to nicotinamidase
|||||||||||||-----------------------------------------------------  1 [KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon
|-|||||||||||-----------------------------------------------------  1 [S] COG1340 Uncharacterized archaeal coiled-coil protein
-|----|||||||||---------------------------------------------------  1 [R] COG1341 Predicted GTPase or GTP-binding protein
|||---|||---------------------|-----------------|-----------------  1 [R] COG1342 Predicted DNA-binding proteins
--|---||------------||--------||--|-||----|||||-||||-|||-----|----  1 [M] COG1346 Putative effector of murein hydrolase
|-|-|||||-|||---||------------------------------------------------  1 [R] COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)
---|||||--|||---||||--|||||||||-------------------------|||-----||  1 [F] COG1351 Predicted alternative thymidylate synthase
--||--|||--------|-|----||----|----|||----|||||-||-----|--|||-||--  1 [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins
-||||||||-------||||||--|-||||||||||||||||-------|--||||---|||||--  1 [S] COG1354 Uncharacterized conserved protein
|||-|||||||||||-||--------------------------------------------|---  1 [R] COG1355 Predicted dioxygenase
||-|--||----------------------------------------------------------  1 [S] COG1356 Uncharacterized protein conserved in archaea
||||||||||||||||-|--|---------||||||||----------------------------  1 [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a)
-||||||||-||-----|------------------------------------------------  1 [M] COG1361 S-layer domain
||----||-|--------------------------------------------------------  1 [R] COG1365 Predicted ATPase (PP-loop superfamily)
||||--||||-||||---------------------------------------------------  1 [J] COG1369 RNase P/RNase MRP subunit POP5
|||||||||||||-----------------------------------------------------  1 [O] COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit
|||||||||||||---||---------||-------------------------------------  1 [S] COG1371 Uncharacterized conserved protein
-|----||||--||||--------------------------------------------------  1 [J] COG1374 Protein involved in ribosomal biogenesis, contains PUA domain
|||||||||||||--------|--------------|-----------------------------  1 [K] COG1378 Predicted transcriptional regulators
|||---||-|--------------------------||----------------------------  1 [S] COG1379 Uncharacterized conserved protein
--|---||------------||--------||--|-||----|||||-||||-|||-----|----  1 [R] COG1380 Putative effector of murein hydrolase LrgA
|||||||||||||||---------------------------------------------------  1 [O] COG1382 Prefoldin, chaperonin cofactor
||||||||||||||||--------------------------------------------------  1 [J] COG1383 Ribosomal protein S17E
||||||||||--|-----------||-----------------------------------|||||  1 [J] COG1384 Lysyl-tRNA synthetase (class I)
--|-|||||--------|||||--|-||||||||||||||||-------|--||||---|||||--  1 [K] COG1386 Predicted transcriptional regulator containing the HTH domain
|||-||||||---||-||--||-----||-||--||||----|||||-|-----------|-----  1 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family
||||--|||||||-----------------------------------------------------  1 [L] COG1389 DNA topoisomerase VI, subunit B
|||||||||||-||||----||||||----------------------------------------  1 [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D
|||||||||||||-----------------------------------------------------  1 [K] COG1395 Predicted transcriptional regulator
||||||||||||||||--------------------------------------------------  1 [U] COG1400 Signal recognition particle 19 kDa protein
||||||||||||||||--------------------------------------------------  1 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
||||||||||||||||--------------------------------------------------  1 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
|---|||||||||-----------------------------------------------|-|---  1 [S] COG1415 Uncharacterized conserved protein
||||||||||------||--||--||----|||||||||-|||||-|---------|||||-----  1 [R] COG1418 Predicted HD superfamily hydrolase
||||||||||--------------------------------------------------------  1 [S] COG1422 Predicted membrane protein
|||---||||--|---|-------------------------------------------------  1 [L] COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III
||-|--||-||------|||----||--------------------------|--|---|||||--  1 [S] COG1430 Uncharacterized conserved protein
||||||||||||||||----||--|--------|--------------------------------  1 [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F
||||||||||||||||--------------------------------------------------  1 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
---|--||||||||||--------------------------|||||-|-||--------------  1 [R] COG1444 Predicted P-loop ATPase fused to an acetyltransferase
---|||||--||--|---||----------------------|||-|-|------|---|---|--  1 [E] COG1446 Asparaginase
|-|||||||--||||-||--|-----|---||-|||||----|||||-||-|---|---||||---  1 [C] COG1454 Alcohol dehydrogenase, class IV
----||||---|-|---------------------|||----|||-|--|-|-||-----------  1 [F] COG1457 Purine-cytosine permease and related proteins
|||---||||--|---|-------------------------------------------------  1 [R] COG1458 Predicted DNA-binding protein containing PIN domain
|||||||||||||-----------------------------------------------------  1 [S] COG1460 DNA-directed RNA polymerase, subunit F
||||||||||||||||--------------------------------------------------  1 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit
|||---|||-|||---||-||-----------|----|----------------------------  1 [L] COG1468 RecB family exonuclease
||||||||||--|----|----------------|-||-----------|--||||----------  1 [S] COG1469 Uncharacterized conserved protein
--|---|||----------------------------|----------------------------  1 [S] COG1470 Predicted membrane protein
||||||||||||||||--------------------------------------------------  1 [J] COG1471 Ribosomal protein S4E
--||||||---|-----|||||----|||-||-|||||----|||----|||---|--||||||--  1 [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase
|-|||||||-||||||--------------------------------------------------  1 [LO] COG1474 Cdc6-related protein, AAA superfamily ATPase
||-|--|||-|||---|--|-|||||||||||||||||----|||||-||--||||||||||||||  1 [K] COG1475 Predicted transcriptional regulators
||||---||----------|-|--------||||||||-----------|-------------|--  1 [K] COG1476 Predicted transcriptional regulators
------||||--|----|------------------------------------------|-----  1 [R] COG1483 Predicted ATPase (AAA+ superfamily)
--|||||||||||||-||||||--|||||-||||||||||||||||||||-|||||--|||||---  1 [H] COG1488 Nicotinic acid phosphoribosyltransferase
|||||||||||||-----------------------------------------------------  1 [J] COG1491 Predicted RNA-binding protein
||||||||||||||||--------------------------------------------------  1 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog
||||||||||||||||--------------------------------------------------  1 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay
||||||||||||||||--------------------------------------------------  1 [J] COG1500 Predicted exosome subunit
|||||||||||||||||-------------------------------------------------  1 [J] COG1503 Peptide chain release factor 1 (eRF1)
|-|---||||--------------------------------------------------------  1 [S] COG1504 Uncharacterized conserved protein
------||-----------|-|----|||------------------------||-------||||  1 [E] COG1505 Serine proteases of the peptidase family S9A
-|----||--------------------------|-|------------------|---|-|----  1 [K] COG1510 Predicted transcriptional regulators
|||-|||||||||---||-|-|----|---|---|-||----|||||--|-----|---|||||--  1 [J] COG1514 2'-5' RNA ligase
---||||||||||-|-||-|-|--------|-----|-----|||||-----|-------------  1 [L] COG1515 Deoxyinosine 3'endonuclease (endonuclease V)
||||--|||--------|---|---|-|||------|-----|||||-||--|--|-------|||  1 [S] COG1520 FOG: WD40-like repeat
----|||||--|-|||-|-|------|---|----|-|-----------|--|-----|-|-||--  1 [R] COG1524 Uncharacterized proteins of the AP superfamily
||-|--||-|---||-|--|------|-------|-|--|||-------|||-||---|||||---  1 [L] COG1525 Micrococcal nuclease (thermonuclease) homologs
|||||||||||--|||----||----------||--------------------------------  1 [C] COG1527 Archaeal/vacuolar-type H+-ATPase subunit C
---|--||-||||---|||||-||--|||||----|-|----||||||||||||||---|||||||  1 [J] COG1530 Ribonucleases G and E
||-----||||||-----------------------------------------------------  1 [S] COG1531 Uncharacterized protein conserved in archaea
||||--||||-||-------|---------||||||||----|||||-||||||||----------  1 [J] COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
||||||||||||||||--------------------------------------------------  1 [R] COG1537 Predicted RNA-binding proteins
------||------------||----|--|----|-||----|||||-|||--|||--||------  1 [R] COG1540 Uncharacterized proteins, homologs of lactam utilization protein B
------||----------||----|--||||------|----------------------------  1 [S] COG1543 Uncharacterized conserved protein
|||||||||||||--------------||----------------------------------|--  1 [R] COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon
||||||||||-|------------------------------------------------------  1 [J] COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain
||||||||||||||||--------------------------------------------------  1 [J] COG1552 Ribosomal protein L40E
-|----|||-------|-------------------------------------------------  1 [R] COG1568 Predicted methyltransferases
-|----|||---------||--------------------------------|-------------  1 [R] COG1569 Predicted nucleic acid-binding protein, contains PIN domain
|||||||||||||-----------------------------------------------------  1 [R] COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
|-|---|||----------|----------------------------------------------  1 [S] COG1572 Uncharacterized conserved protein
--|||||||-|||---||||||--|--|||||||--------------|-|--|||||||||||||  1 [L] COG1573 Uracil-DNA glycosylase
--||||||----|---||--||-----||------|||--------|--|-----|---|||||--  1 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold
||||--||||||||||---------|-----|||||------------------------------  1 [I] COG1577 Mevalonate kinase
|||---|||||-----||------------------------------------------------  1 [S] COG1578 Uncharacterized conserved protein
||--|||||||||-----------------------------------------------------  1 [K] COG1581 Archaeal DNA-binding protein
-|--|||||-|||---||------------|-----||----||||||-|--|--|----------  1 [E] COG1586 S-adenosylmethionine decarboxylase
||||||||||--|-----------------------------------------------------  1 [J] COG1588 RNase P/RNase MRP subunit p29
||-|--|||||||-----------------------------------------------------  1 [L] COG1591 Holliday junction resolvase - archaeal type
|||----|||-|-----|-||---------|-----|---------------------|-------  1 [C] COG1592 Rubrerythrin
|||||||||-||||||--------------------------------------------------  1 [K] COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS
||||||||||-|||||--------------------------------------------------  1 [L] COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
||||||||||||||||--------------------------------------------------  1 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain
|-|||||||||||-----------------------------------------------------  1 [S] COG1602 Uncharacterized conserved protein
||||--||||-||||---------------------------------------------------  1 [J] COG1603 RNase P/RNase MRP subunit p30
|||||||||||||-----------------------------------------------------  1 [R] COG1608 Predicted archaeal kinase
--|-||||||||-|--||-|||||--||||-|--|-||----|||||-||-|||||--||||||--  1 [R] COG1611 Predicted Rossmann fold nucleotide-binding protein
|||---||||--------------------------------------------------------  1 [S] COG1617 Uncharacterized conserved protein
|||-|||||||||---||------------------------------------------------  1 [F] COG1618 Predicted nucleotide kinase
-|||--||||------|-||-|||||----||||||||-|||------------------------  1 [S] COG1624 Uncharacterized conserved protein
|||---||-|--------||-|--------|-----------------------------------  1 [C] COG1625 Fe-S oxidoreductase, related to NifB/MoaA family
||----||-|--------------------------------------------------------  1 [S] COG1627 Uncharacterized protein conserved in archaea
|||||||||||||--------|--------------------------------------------  1 [S] COG1628 Uncharacterized conserved protein
||--|||||--||-----------------------------------------------------  1 [S] COG1630 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1631 Ribosomal protein L44E
||||||||||||||||--------------------------------------------------  1 [J] COG1632 Ribosomal protein L15E
|||||||||||||-----------------------------------------------------  1 [R] COG1634 Uncharacterized Rossmann fold enzyme
||||--|||||||||--|------------------------------------------------  1 [H] COG1635 Flavoprotein involved in thiazole biosynthesis
||-|--||-||||------|------||||------------------------------------  1 [L] COG1637 Predicted nuclease of the RecB family
||||||||||||||||--------------------------------------------------  1 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
-|||--|||||||-----------------------------------------------------  1 [R] COG1645 Uncharacterized Zn-finger containing protein
|||||||||||||---------------------||||----------------------------  1 [R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold
-||||||||||||-----------------------------------------------------  1 [S] COG1650 Uncharacterized protein conserved in archaea
---|||||--|||----|||-|--|-||||||||-|||----|||||-||-||--|---||||---  1 [G] COG1653 ABC-type sugar transport system, periplasmic component
--||---||------------|--------||||||||----|||||-|||||-------------  1 [K] COG1654 Biotin operon repressor
----|||||||||---||------|--||--------------------------|----------  1 [S] COG1656 Uncharacterized conserved protein
|||-|||||-------|---|----|----|||||||||-||------------------------  1 [L] COG1658 Small primase-like proteins (Toprim domain)
|-||||||||--|---------------------|--------||-|-|----------||-|---  1 [R] COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif
||||--|||-|||----|---|--------||-|||||--------------|----------|--  1 [CP] COG1668 ABC-type Na+ efflux pump, permease component
-|||||-|-----||--|-|||----||||||||||||--|-|||||-||-|-|||||||||||||  1 [J] COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
||||--||||||||||--------------------------------------------------  1 [K] COG1675 Transcription initiation factor IIE, alpha subunit
||||||||||||||||--------------------------------------------------  1 [J] COG1676 tRNA splicing endonuclease
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1679 Uncharacterized conserved protein
--|---||--|-|-----||-|----||||||||||||----|||||--|--|--|---|||||||  1 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins
||||||-||||||-----------------------------------------------------  1 [EH] COG1685 Archaeal shikimate kinase
|||---|||-|||---||------------------------------------------------  1 [L] COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|-----|||---------------------------------------------------------  1 [S] COG1689 Uncharacterized protein conserved in archaea
||||--||||||||||--------------------------------------------------  1 [L] COG1697 DNA topoisomerase VI, subunit A
|||-||||||-||-----------------------------------------------------  1 [S] COG1698 Uncharacterized protein conserved in archaea
||||--|||||||-----------------------------------------------------  1 [S] COG1701 Uncharacterized protein conserved in archaea
---||||||--||--------|----||||-------|----|||----------|-------|--  1 [E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family
-||||||||||||-----------------------------------------------------  1 [K] COG1709 Predicted transcriptional regulator
||----||----------------------------------------------------------  1 [S] COG1710 Uncharacterized protein conserved in archaea
|-|||||||---------------------------------------------------------  1 [S] COG1711 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1717 Ribosomal protein L32E
||||||||||||||||-----|-----------------------|---|----------------  1 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control
||||||||||||||||--------------------------------------------------  1 [J] COG1727 Ribosomal protein L18E
|||||||||||||||-|-------------------------------------------------  1 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding
||||||||||||||||--------------------------------------------------  1 [J] COG1736 Diphthamide synthase subunit DPH2
------||||--|----|------------------------------------------|-----  1 [L] COG1743 Adenine-specific DNA methylase containing a Zn-ribbon
---|--|||-|-|----|-|-|--||----||||-|||||||-------|-----|---||||---  1 [R] COG1744 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein
|||||||||||||-----------------------------------------------------  1 [J] COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme)
-||---|||-|||-----------------------------------------------------  1 [R] COG1750 Archaeal serine proteases
-||---|||---------------------------------------------------------  1 [S] COG1753 Uncharacterized conserved protein
-|--||||||||||||--------------------------------------------------  1 [S] COG1756 Uncharacterized conserved protein
---|--||----|-------|----|----|---|-||-------||-|-||-||-|||-------  1 [C] COG1757 Na+/H+ antiporter
||||||||||||||||||||-|--||||||||||||||----|||||-||||||||||||||||||  1 [K] COG1758 DNA-directed RNA polymerase, subunit K/omega
||||||||||||||||--------------------------------------------------  1 [K] COG1761 DNA-directed RNA polymerase, subunit L
|||||-|||||||---|-----------------||||----|||||-|-||---|--|||||---  1 [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein
|||---||||-||-------|-----------|---------|||-|-|||---------------  1 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase
||----||----------------------------------------------------------  1 [S] COG1771 Uncharacterized protein conserved in archaea
-||---||||--------------------------------------------------------  1 [S] COG1772 Uncharacterized protein conserved in archaea
||-----||--------||||---|--||-|-----------|||-|--|--||||-------|--  1 [C] COG1773 Rubredoxin
|||-|||||||||||---------------------------------------------------  1 [R] COG1779 C4-type Zn-finger protein
|||||||||||||----|------------|-----------|||||||----||-----------  1 [F] COG1781 Aspartate carbamoyltransferase, regulatory subunit
|||||||||||||-----------------------------------------------------  1 [R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain
||||--||||--------------------------------------------------------  1 [S] COG1784 Predicted membrane protein
--||---|-----||--|-|-|----|-------|-||----||||---|--|--|-----|----  1 [P] COG1785 Alkaline phosphatase
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1786 Uncharacterized conserved protein
|||||||||||||||||----------||-------||----------|||--||---|||-||--  1 [L] COG1793 ATP-dependent DNA ligase
||||||||||||||||--------------------------------------------------  1 [J] COG1798 Diphthamide biosynthesis methyltransferase
--|-|||||-|||---||-|-|------------||||----|||||-||-|---|---||-||--  1 [S] COG1801 Uncharacterized conserved protein
------|||-------|-|||---------|-----|-----|||||--|--||||---|||||--  1 [M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
|||||||||||||---|---------------|---------------------------------  1 [E] COG1812 Archaeal S-adenosylmethionine synthetase
||||||||||||||||--------------------------------------------------  1 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1
||--|||||||||||--|---||---|----|-----------------|------------||--  1 [S] COG1814 Uncharacterized membrane protein
|-||--||||--|-----------------------------------------------------  1 [P] COG1824 Permease, similar to cation transporters
||||||||||||----||||-|----||||-|--||||--------------------|-||||--  1 [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component
||||--|||||||-----------------------------------------------------  1 [R] COG1829 Predicted archaeal kinase (sugar kinase superfamily)
||||--||||-||---|--|--||------------------|||||----|-------||-|---  1 [G] COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes
|||||||||||-|-----------------------------------------------------  1 [R] COG1831 Predicted metal-dependent hydrolase (urease superfamily)
---|||||--|||---||---|---------|||-|||----|||||--------|--|||-|---  1 [R] COG1832 Predicted CoA-binding protein
||||-|||||||-----|------------------------------------------------  1 [S] COG1833 Uncharacterized conserved protein
|||||||||-|-------||-----------------|----------------------------  1 [S] COG1836 Predicted membrane protein
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain
|---|||||-|||----|---------||--------------------------|----------  1 [S] COG1839 Uncharacterized conserved protein
||||||||||||||||||--||--||||||||||||||----||||||||||||||----||||||  1 [J] COG1841 Ribosomal protein L30/L7E
|||---||-|--------------------------------------------------------  1 [S] COG1844 Uncharacterized protein conserved in archaea
|||||||||||||----|-|||----||||||||||||----|||||-||--||||---|||||--  1 [K] COG1846 Transcriptional regulators
|||||||||||||-----------------------------------------------------  1 [S] COG1849 Uncharacterized protein conserved in archaea
-||---|||---------||----------------|-----------------------|-|---  1 [G] COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit
-|----||--------|-------------------------------------------------  1 [S] COG1851 Uncharacterized conserved protein
|||----||-----------|---------------------------------------------  1 [S] COG1852 Uncharacterized conserved protein
|-|-|-|||-|||-|-||||||----||||||-|||||----|||||--|-|-|||---|||||||  1 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family
|||||||||||||-----------------------------------------------------  1 [R] COG1855 ATPase (PilT family)
------||---|----||------------------------------------------------  1 [S] COG1856 Uncharacterized homolog of biotin synthetase
|||---|||-|||---|---|---------------------------------------------  1 [L] COG1857 Uncharacterized protein predicted to be involved in DNA repair
--|-|||||||-|||-----||--------------------|||----|---------|------  1 [J] COG1859 RNA:NAD 2'-phosphotransferase
-||||||||||||-----------------------||----------------------------  1 [S] COG1865 Uncharacterized conserved protein
|||||||||||||||||-------------------------------------------------  1 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase
--||--|||--------|-------|----|-----||----------||-----|---||--|--  1 [NT] COG1871 Chemotaxis protein; stimulates methylation of MCP proteins
|||----|||--|------|--||----|-------------|||||-|--|-------|--||||  1 [S] COG1872 Uncharacterized conserved protein
||||||||||--------------------|-----||----------------------------  1 [S] COG1873 Uncharacterized conserved protein
------||---------|------------|--|--||-------|------|-------|--|--  1 [G] COG1874 Beta-galactosidase
||||||-||-||-----|||------|||-----|--|-----------|||---|---||-|---  1 [R] COG1878 Predicted metal-dependent hydrolase
|-|||||||--|-|--|-----||--|||||---|-|-|---|||-|-|--|||||||-||-|--|  1 [R] COG1881 Phospholipid-binding protein
------|||--------|--|---|-------|-------------|-|--|--------------  1 [C] COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit
---||||||--||--------|----||||-------|----|||----------|---|||||--  1 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit
-|||--||||--------------------------------------------------------  1 [S] COG1885 Uncharacterized protein conserved in archaea
||--|||||||||-----------------------------------------------------  1 [S] COG1888 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1889 Fibrillarin-like rRNA methylase
||||||||||||||||--------------------------------------------------  1 [J] COG1890 Ribosomal protein S3AE
|-||--||||||------------------------------------------------------  1 [S] COG1892 Uncharacterized protein conserved in archaea
---|--|||-|-|||-|--|------|||-|||-||||----|||||-||-----|------||--  1 [H] COG1893 Ketopantoate reductase
---|--|||||||||------|------------||------|||||-||-|----||||||||--  1 [R] COG1896 Predicted hydrolases of HD superfamily
|-|--||||--||-----||||----|||||||||-||----|---|--|-|||||--||||||--  1 [M] COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes
||||||||||||||||---|-------------------------------------------|--  1 [O] COG1899 Deoxyhypusine synthase
-|||--|||||-|-----------------------------------|-----------------  1 [S] COG1901 Uncharacterized conserved protein
------|||-|------|------------------------------------------------  1 [S] COG1906 Uncharacterized conserved protein
|||-|||||||||-----------------------------------------------------  1 [S] COG1909 Uncharacterized protein conserved in archaea
|||---||||||||||--------------------------------------------------  1 [J] COG1911 Ribosomal protein L30E
-|||--|||||||---||-|-------------|||-------||-----------||--------  1 [S] COG1912 Uncharacterized conserved protein
||||--||||--------------||--------------------------|-------------  1 [S] COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein)
|||----|||-------||--|--------||--||------|||||-||--|--|-||----|--  1 [P] COG1918 Fe2+ transport system protein A
||||--|||||||-----------------------------------------------------  1 [S] COG1931 Uncharacterized protein conserved in archaea
-||---||||--------------------------------------------------------  1 [S] COG1935 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)
|||||||||||||-----------------------------------------------------  1 [R] COG1938 Archaeal enzymes of ATP-grasp superfamily
||||||||||------------||------------------------------------------  1 [S] COG1945 Uncharacterized conserved protein
||||--||||||||||--------------------------------------------------  1 [L] COG1948 ERCC4-type nuclease
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain
-||||||||--||-----------------------------------------------------  1 [NU] COG1955 Archaeal flagella assembly protein J
|-||||||||||||||--------------------------------------------------  1 [K] COG1958 Small nuclear ribonucleoprotein (snRNP) homolog
--|----|--|-|---|---|-----|||-||----||----|||||-||||-||||||-------  1 [T] COG1966 Carbon starvation protein, predicted membrane protein
||||||||||||||||--------------------------------------------------  1 [J] COG1976 Translation initiation factor 6 (eIF-6)
||--|||||||||---|-------------------------------------------------  1 [G] COG1980 Archaeal fructose 1,6-bisphosphatase
--|---||---------|--------|---||||-|||----|||||-|-----------------  1 [KT] COG1983 Putative stress-responsive transcriptional regulator
------||-----|------||----||||----|-||----|||||-|||--|||--||---|--  1 [E] COG1984 Allophanate hydrolase subunit 2
|||---||||--|-----------------|---||||----|||||--|-|--------------  1 [R] COG1988 Predicted membrane-bound metal-dependent hydrolases
||||||||||||||||----------|---------------------------------------  1 [S] COG1990 Uncharacterized conserved protein
||----||-|--------------------------------------------------------  1 [S] COG1991 Uncharacterized conserved protein
-||---||-|------||---------||--------------------------------|-|--  1 [S] COG1993 Uncharacterized conserved protein
||||||-||||||---||||-|-----||-|----|||----------|----|||||--|-||--  1 [R] COG1994 Zn-dependent proteases
|||||||||||||||---------------|-----------------------------------  1 [K] COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger)
||||||||||||||||--------------------------------------------------  1 [J] COG1997 Ribosomal protein L37AE/L43A
|||||||||||||||---------------------------------------------------  1 [J] COG1998 Ribosomal protein S27AE
||||||||||||||||--------------------------------------------------  1 [J] COG2004 Ribosomal protein S24E
||||||||||||||||--------------------------------------------------  1 [J] COG2007 Ribosomal protein S8E
||||||||||||||||--------------------------------------------------  1 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5
|-||||-|||-||----||--|--------|||----------------|------------||--  1 [S] COG2013 Uncharacterized conserved protein
|||---||----------------------------------------------------------  1 [S] COG2014 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2016 Predicted RNA-binding protein (contains PUA domain)
||--||||-||||------------------------------------------------|----  1 [F] COG2019 Archaeal adenylate kinase
--|---|||---||||--||-------||-|-----------------|-||---|----|||---  1 [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase
||||||||||-|||||--------------------------------------------------  1 [J] COG2023 RNase P subunit RPR2
-|----|||---------------------------------------------------------  1 [S] COG2028 Uncharacterized conserved protein
|||---||-|--------------------------------------------------------  1 [S] COG2029 Uncharacterized conserved protein
|||---|||--------|------|-----|-----------------------------------  1 [C] COG2033 Desulfoferrodoxin
|||-||||||-||-----------------------------------------------------  1 [S] COG2034 Predicted membrane protein
|||||||||||||-----||||----|||||------|----|||-|-||-----|---|||||--  1 [H] COG2038 NaMN:DMB phosphoribosyltransferase
------||---|--------||-----||---|||-||-------|---------|----------  1 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)
-------||-|||||-|-||-|--------------||--------------------|-------  1 [P] COG2046 ATP sulfurylase (sulfate adenylyltransferase)
||||||||||--------------------------------------------------------  1 [R] COG2047 Uncharacterized protein (ATP-grasp superfamily)
------||-----|------||----||||----|-||----|||-|-|||--|||--||---|--  1 [E] COG2049 Allophanate hydrolase subunit 1
--|||||||-||--|-|----|----|||--|||||||----|||||-||||---|||||||||--  1 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism
||||||||||||||||--------------------------------------------------  1 [J] COG2051 Ribosomal protein S27E
||||||||||||||||--------------------------------------------------  1 [J] COG2053 Ribosomal protein S28E/S33
||----||-|----------------|---|-----|-----|||-|--|||-------||||---  1 [C] COG2055 Malate/L-lactate dehydrogenases
||||||||||||||||--------------------------------------------------  1 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2
||--||||-|-----------|--------------------------------------------  1 [G] COG2074 2-phosphoglycerate kinase
||||||||||||||||--------------------------------------------------  1 [J] COG2075 Ribosomal protein L24E
|||||||||||||||-||------------|-----------------------------------  1 [S] COG2078 Uncharacterized conserved protein
||----||||--------------------------------------------------------  1 [S] COG2083 Uncharacterized protein conserved in archaea
||-|--|||||||-----------------------------------------------------  1 [S] COG2090 Uncharacterized protein conserved in archaea
|||||||||||||||---------------------------------------------------  1 [J] COG2092 Translation elongation factor EF-1beta
|||||||||||||-----------------------------------------------------  1 [K] COG2093 DNA-directed RNA polymerase, subunit E''
---||||||-|||-------||----||||-----|||--------|--|-----|---|||||--  1 [S] COG2096 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2097 Ribosomal protein L31E
-|----|||||-|-----------------------------------------------------  1 [R] COG2100 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB
|-|||||||-------|-||||----|||||-----||----||--|-||--||||--||-|||--  1 [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis
|--|--|||||||||---------------------------------------------------  1 [S] COG2106 Uncharacterized conserved protein
-|||--|||||||-----------------|-----------------------------------  1 [R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme
--||||||--|------|||||-----||-------------|||||-||-----|---||||---  1 [H] COG2109 ATP:corrinoid adenosyltransferase
--|-||||||||||--||--||-----||---|-||------|||-|--|-----|------|---  1 [R] COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1
-|----|||-|||---|-------------------------------------------------  1 [T] COG2112 Predicted Ser/Thr protein kinase
||||--||----------------------------------------------------------  1 [J] COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain
|||||||||||||||---------------------------------------------------  1 [R] COG2118 DNA-binding protein
--|---||-|-|-|||-----|----||||----|-||----|--|-------------||||---  1 [S] COG2120 Uncharacterized proteins, LmbE homologs
|-|-||||||||||||--------------------------------------------------  1 [J] COG2123 RNase PH-related exoribonuclease
||||||||||||||||--------------------------------------------------  1 [J] COG2125 Ribosomal protein S6E (S10)
||||||||||-|||||--------------------------------------------------  1 [J] COG2126 Ribosomal protein L37E
|||---|||||||---|-------------------------------------------|-----  1 [R] COG2129 Predicted phosphoesterases, related to the Icc protein
--|-||||||---||--|--||--|-----||||||||-|--------|-----------------  1 [F] COG2131 Deoxycytidylate deaminase
|||---||||||||||--------------------------------------------------  1 [JA] COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain
||||||||||||||||--------------------------------------------------  1 [J] COG2139 Ribosomal protein L21E
--|---|||---------|-----------------|---------|--------|---||-|---  1 [GR] COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes
--|---|||----||-----------|---||-|||||----|||-|---||----||-|------  1 [H] COG2145 Hydroxyethylthiazole kinase, sugar kinase family
||||||||||||||||--------------------------------------------------  1 [J] COG2147 Ribosomal protein L19E
|||-||||-||||----|---|----||||-|||||||----|---------|--|---|||||--  1 [R] COG2151 Predicted metal-sulfur cluster biosynthetic enzyme
--|---||----|---||-----------------|---------|--------------------  1 [G] COG2152 Predicted glycosylase
|||---||||||||||--------------------------------------------------  1 [J] COG2157 Ribosomal protein L20A (L18A)
---|--||-|-||-----|-------|||-|---||-----------------------||-||--  1 [R] COG2159 Predicted metal-dependent hydrolase of the TIM-barrel fold
||----||-|||||||--------------|------|----------------------------  1 [J] COG2163 Ribosomal protein L14E/L6E/L27E
||||||||||-|||||--------------------------------------------------  1 [J] COG2167 Ribosomal protein L39E
||----||-|||||||--------------------------------------------------  1 [J] COG2174 Ribosomal protein L34E
-||---|||||||-|---------------------------------------------------  1 [J] COG2178 Predicted RNA-binding protein of the translin family
---||||||--||-------||----||||-------|----|||----------|---|||||--  1 [I] COG2185 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)
|-|-|||||------------|--------------------------------------------  1 [C] COG2191 Formylmethanofuran dehydrogenase subunit E
-|----||-|--------|--|---------------------------|-----|----|-|---  1 [O] COG2192 Predicted carbamoyl transferase, NodU family
--||--|||--------|-|----||----|-----||----|||||-||--|--|--|||-||--  1 [NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain
|-||||-||-|||||-|||||||||-|||||||||||||---|||||-||||-|||||||||||--  1 [P] COG2217 Cation transport ATPase
||||||||||||||||--------------------------------------------------  1 [L] COG2219 Eukaryotic-type DNA primase, large subunit
|-----||-|-------|--||--------|-||-||-----|||||--|--|------|||||--  1 [M] COG2222 Predicted phosphosugar isomerases
-------|------|--|--||----|---||||||||----|||||-||||-|||---|||----  1 [F] COG2233 Xanthine/uracil permeases
|-||--||||---||-|--|-------||-|-----||----|||-|-||--|----------|--  1 [R] COG2234 Predicted aminopeptidases
-||||||||-|||-----------------------------------------------------  1 [S] COG2237 Predicted membrane protein
||||||||||||||||--------------------------------------------------  1 [J] COG2238 Ribosomal protein S19E (S16A)
-|----||--|-|----|------------------------------------------------  1 [S] COG2245 Predicted membrane protein
---||||||||||-----||------||||||-||||-----|---|--|-----|------||--  1 [S] COG2246 Predicted membrane protein
-|----|||||||-----------------------------------------------------  1 [R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)
------||---------|||------||||------------------------------------  1 [R] COG2251 Predicted nuclease (RecB family)
-|-|--||------|--|||||--|||---||||||||-|--|||||-||||-||||||-||-|--  1 [R] COG2252 Permeases
-|----|||-|||-----------------------------------------------------  1 [L] COG2254 Predicted HD superfamily hydrolase, possibly a nuclease
|||||||||||||||---------------------------------------------------  1 [J] COG2260 Predicted Zn-ribbon RNA-binding protein
-|||--||-||||---||||||||--||||||||||||----|||||-||-|||||---|||||--  1 [R] COG2262 GTPases
|||||||||||||--|--------------------------------------------------  1 [J] COG2263 Predicted RNA methylase
|||||||||||||-----------------------------------------------------  1 [H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase
-------||----||--|-|||----||||||--||||----|||||-||||---|---|||||--  1 [I] COG2267 Lysophospholipase
------||-------------|----|||-----|-------------------------------  1 [S] COG2306 Uncharacterized conserved protein
---|--||--|||-------||-------------|||-------|--|-------------|--|  1 [E] COG2317 Zn-dependent carboxypeptidase
---|--||-----------|-|----|-----||||||----------------------------  1 [S] COG2339 Predicted membrane protein
------||--|||-|------|||-----------|-|-----------|-----|---|||||--  1 [E] COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog
------||----|--------|-------------||------------------|------|---  1 [E] COG2362 D-aminopeptidase
----||||--|||----|---|---------------------------|-----|---||||---  1 [G] COG2379 Putative glycerate kinase
-|----||----|--------|--------------------------------------------  1 [S] COG2383 Uncharacterized conserved protein
------||||--|--------------------------------|--------------------  1 [R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain
------||--|-|----|------------|--|--------|||||---|---------------  1 [G] COG2407 L-fucose isomerase and related proteins
--||||||||-||-----------------------------------------------------  1 [S] COG2412 Uncharacterized conserved protein
------||||-||-----------------------------------------------------  1 [R] COG2413 Predicted nucleotidyltransferase
------|||||||-----------------------------------------------------  1 [S] COG2419 Uncharacterized conserved protein
------||---||-|--|-|---------------|-|----------------------|--|--  1 [C] COG2421 Predicted acetamidase/formamidase
------|||---|------------------------|----------------------------  1 [S] COG2426 Predicted membrane protein
------||-|--||----------------------------------------------------  1 [S] COG2428 Uncharacterized conserved protein
--|---|||-|-|-----------------------------------------------------  1 [S] COG2430 Uncharacterized conserved protein
------||--|||-------|---------------------|||||-|-||-||-----------  1 [S] COG2431 Predicted membrane protein
|-||--|||||||-----------------------------------------------------  1 [S] COG2433 Uncharacterized conserved protein
------|||--||-----------------------------------------------------  1 [C] COG2441 Predicted butyrate kinase
||||||||||--||||--------------------------------------------------  1 [U] COG2443 Preprotein translocase subunit Sss1
||||||||||--------------------------------------------------------  1 [S] COG2450 Uncharacterized conserved protein
------||-|--||||--------------------------------------------------  1 [J] COG2451 Ribosomal protein L35AE/L33A
-|--||-|---|-------|-------||-----------------------|-------------  1 [L] COG2452 Predicted site-specific integrase-resolvase
-||---||--||-||----|-|----|---------------||||--||----------------  1 [T] COG2453 Predicted protein-tyrosine phosphatase
|||---||-|-|------------------|-----------------------------------  1 [S] COG2454 Uncharacterized conserved protein
||----||----------------------------------------------------------  1 [S] COG2456 Uncharacterized conserved protein
|||---||||-|------------------------------------------------------  1 [S] COG2457 Uncharacterized conserved protein
-------||--------|--|---------||-|---|----------------------------  1 [S] COG2461 Uncharacterized conserved protein
-|||--|||---------------------------------------------------------  1 [S] COG2469 Uncharacterized conserved protein
--|---||||||-----||-|---------||-----|----------|--------------|--  1 [R] COG2509 Uncharacterized FAD-dependent dehydrogenases
||----||-|---------|-------------------------|---|---||----|-|----  1 [S] COG2510 Predicted membrane protein
|||||||||||||-----------------------------------------------------  1 [J] COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain)
------||------|--|-|----------------------|||||-|------|--|---||--  1 [E] COG2515 1-aminocyclopropane-1-carboxylate deaminase
--|---||---|----|||-----------------------------------------------  1 [R] COG2516 Biotin synthase-related enzyme
|-----||||--------------------------------------------------------  1 [R] COG2517 Predicted RNA-binding protein containing a C-terminal EMAP domain
||||--|||||||-|--|------------------------|||||-||--||||||||||||--  1 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase
||-||||||||||||-||--------||||------------------------------------  1 [J] COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases
-|----||-||-|---------------------------------------|-------------  1 [R] COG2521 Predicted archaeal methyltransferase
------||-----||--|-|----------|-----||--------------|--|----------  1 [G] COG2730 Endoglucanase
------||----|--------|--------------------------------------------  1 [V] COG2810 Predicted type IV restriction endonuclease
|||||||||------------|--------------------------------------------  1 [C] COG2811 Archaeal/vacuolar-type H+-ATPase subunit H
-|----||-|-|-----|---|---------|||||||----||||||||||-------|||||--  1 [J] COG2813 16S RNA G1207 methylase RsmC
-||||||||--||-----------------------------------------------------  1 [NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella
----||-|--|||----|||||||------|-|-||||---------------|------------  1 [E] COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase
---|--|||-|-|-----||----------------------------------------------  1 [S] COG2886 Uncharacterized small protein
|||||||||||||-----------------------------------------------------  1 [J] COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG2890 Methylase of polypeptide chain release factors
|||---||||--|-----------------------------------------------------  1 [S] COG2892 Uncharacterized protein conserved in archaea
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [H] COG2896 Molybdenum cofactor biosynthesis enzyme
--||---|------|------------||-------------|||||--|||-------|||||--  1 [P] COG3119 Arylsulfatase A and related enzymes
------||---|---------|----||||-------------------|-----|---|||||--  1 [EQ] COG3191 L-aminopeptidase/D-esterase
---||||||--||------------------------------------|----------------  1 [S] COG3199 Uncharacterized conserved protein
-|----||------------------|||--------------------|-----|----------  1 [R] COG3233 Predicted deacetylase
------|||-----------------------||--------|||-|-|-----------------  1 [S] COG3270 Uncharacterized conserved protein
|||||||||||-||||--------------------------------------------------  1 [J] COG3277 RNA-binding protein involved in rRNA processing
-|----||-||-|-----------------------------------------------------  1 [S] COG3286 Uncharacterized protein conserved in archaea
-|-|||||----------------------------------------------------------  1 [N] COG3351 Putative archaeal flagellar protein D/E
-|-|||||----------------------------------------------------------  1 [N] COG3352 Putative archaeal flagellar protein C
-|-|||-|----------------------------------------------------------  1 [N] COG3353 Putative archaeal flagellar protein F
-|-|||||----------------------------------------------------------  1 [N] COG3354 Putative archaeal flagellar protein G
---|---|||||------------------------------------------------------  1 [K] COG3357 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon
----|||||--|------------------------------------------------------  1 [R] COG3368 Predicted permease
--|||||||-||-------|----------------------------------------------  1 [S] COG3372 Uncharacterized conserved protein
-|--||||----------------------------------------------------------  1 [S] COG3373 Uncharacterized protein conserved in archaea
---|---|---||-----------------------------------------------------  1 [S] COG3379 Uncharacterized conserved protein
--|||||||---------------------------------------------------------  1 [S] COG3390 Uncharacterized protein conserved in archaea
--|-||||---|-|-----|-|---------------|----------------------|-|---  1 [G] COG3408 Glycogen debranching enzyme
||||||||||||||||---------|-----||||||--------|-----------------|--  1 [I] COG3425 3-hydroxy-3-methylglutaryl CoA synthase
--||||||-|||----|-||----------------------------------------------  1 [S] COG3431 Predicted membrane protein
----||||----------|-----------------------------------------------  1 [S] COG3463 Predicted membrane protein
------||---||------------------------------------------|----|-|---  1 [Q] COG3473 Maleate cis-trans isomerase
------||----------------------||---|||-------|--------------------  1 [S] COG3595 Uncharacterized conserved protein
------||---------|------------|||||||-----------------------------  1 [S] COG3601 Predicted membrane protein
--|||||||---------------------------------------------------------  1 [K] COG3620 Predicted transcriptional regulator with C-terminal CBS domains
------|||---------------|---------------------|-|--|--------------  1 [C] COG3630 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit
|||-|||||||||---||---|--------------------------------------------  1 [G] COG3635 Predicted phosphoglycerate mutase, AP superfamily
||||||||||||||||--------------------------------------------------  1 [T] COG3642 Mn2+-dependent serine/threonine protein kinase
-------|-------------------||--------------------------|-------|--  1 [Q] COG3653 N-acyl-D-aspartate/D-glutamate deacylase
--||--||---|------|-----------|-----------|||||--------|----------  1 [L] COG3677 Transposase and inactivated derivatives
------||----------||------|||||||||----------------------------|--  1 [K] COG3682 Predicted transcriptional regulator
------||----|-----------------------------|||-|-------------------  1 [R] COG3769 Predicted hydrolase (HAD superfamily)
-|----||-|--|-----------------------------------------------------  1 [L] COG3780 DNA endonuclease related to intein-encoded endonucleases
----|--|--||-----|---|---------|||||||-|--|||||-|-----------------  1 [G] COG3833 ABC-type maltose transport systems, permease component
---|--|||-|-|----|-|-|--||----||||-||-||||-------|-----|---||||---  1 [R] COG3845 ABC-type uncharacterized transport systems, ATPase components
-------|---------|--|---------|-----------------------------------  1 [S] COG3862 Uncharacterized protein with conserved CXXC pairs
----||||---|------------------|-----------------------------------  1 [S] COG3885 Uncharacterized conserved protein
------||--|||-----------------------------------------------------  1 [R] COG3889 Predicted solute binding protein
------||------------------|---|---|-||----------------------------  1 [S] COG3949 Uncharacterized membrane protein
-|--||-|--|||----|--|------------|-----------||------------||-|---  1 [G] COG3958 Transketolase, C-terminal subunit
-|--||-|--|||----|--|------------|-----------||------------||-|---  1 [G] COG3959 Transketolase, N-terminal subunit
------||||--------------------------------------------------------  1 [S] COG4003 Uncharacterized protein conserved in archaea
|-----||-|--------------------------------------------------------  1 [S] COG4025 Predicted membrane protein
|------|-|--------------------------------------------------------  1 [R] COG4026 Uncharacterized protein containing TOPRIM domain, potential nuclease
------||-|--|-----------------------------------------------------  1 [S] COG4027 Uncharacterized protein conserved in archaea
------||-|-||-----------------------------------------------------  1 [R] COG4028 Predicted P-loop ATPase/GTPase
--||--||-|--------------------------------------------------------  1 [S] COG4044 Uncharacterized protein conserved in archaea
------||-||-|-----------------------------------------------------  1 [S] COG4047 Uncharacterized protein conserved in archaea
-|----||-|--------------------------------------------------------  1 [R] COG4049 Uncharacterized protein containing archaeal-type C2H2 Zn-finger
-|----||-|--------------------------------------------------------  1 [S] COG4072 Uncharacterized protein conserved in archaea
---|--||--|----------|--|-----------------|||||-|-||-||----||||---  1 [H] COG4143 ABC-type thiamine transport system, periplasmic component
------||--|||-----------------------------------------------------  1 [S] COG4345 Uncharacterized protein conserved in archaea
------||--|||-----------------------------------------------------  1 [O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase
---|--|||-|-|----|-|-|--||----||||-||-||||-------|-----|---||||---  1 [R] COG4603 ABC-type uncharacterized transport system, permease component
------||---||-----------------------------------------------------  1 [S] COG4697 Uncharacterized protein conserved in archaea
------||----------------------|||||-------------------------------  1 [S] COG4720 Predicted membrane protein
|-|---||----------------------------------------------------------  1 [S] COG4743 Predicted membrane protein
---|--|||--|-||--|--||----||||------||-----------|-----|---|||||||  1 [I] COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
--|----||---------------------------------------------------------  1 [S] COG4854 Predicted membrane protein
-||----|----------------------------------------------------------  1 [S] COG4902 Uncharacterized protein conserved in archaea
|-|----|----------------------------------------------------------  1 [S] COG4906 Predicted membrane protein
----|--|--|-------------------------------------------------------  1 [G] COG4945 Membrane-anchored protein predicted to be involved in regulation of amylopullulanase
||----||-|----------------|||-|--------------|---|-||--|---||-||--  1 [U] COG4962 Flp pilus assembly protein, ATPase CpaF
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG4992 Ornithine/acetylornithine aminotransferase
||||||||||||||||--------------------------------------------------  1 [J] COG5256 Translation elongation factor EF-1alpha (GTPase)
||||||||||||||||--------------------------------------------------  1 [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)
-||---||-||-------------------------------------------------------  1 [J] COG5270 PUA domain (predicted RNA-binding domain)
------||----------||-------|||----------------|-------------------  1 [S] COG5305 Predicted membrane protein
-||---||-----------------------------------------|----------------  1 [S] COG5306 Uncharacterized conserved protein
---|--||-------------------||-------------------------------------  1 [K] COG5340 Predicted transcriptional regulator
-|-----|----|-----------------------------------------------------  1 [R] COG5378 Predicted nucleotide-binding protein
-||---||----------------------------------------------------------  1 [S] COG5418 Predicted secreted protein
--|---|||---------------------------------------------------------  1 [S] COG5423 Predicted metal-binding protein
-------|------------|---------------||----------------------------  1 [S] COG5505 Predicted integral membrane protein
-------||---------|-----------------------------------------------  1 [S] COG5559 Uncharacterized conserved small protein
------|||----------------------------------------|----------------  1 [S] COG5608 Conserved secreted protein
-------|-|--------------------|-----------------------------------  1 [S] COG5617 Predicted integral membrane protein
------|||-|-|-----------------------------------------------------  1 [K] COG5625 Predicted transcription regulator containing HTH domain
------|---|--||--|--|---|-|||-||-|--||----|||||-|-||--------------  0 [G] COG0153 Galactokinase
-|--|||-----------|||---|-----|----|-|----|||||-|-||||--||-------|  0 [L] COG0338 Site-specific DNA methylase
-----||----|-||--|||-------||--|||-|-|----|-----------------------  0 [G] COG0383 Alpha-mannosidase
-||---|-|-||-||-||||||----|||||||||||-----|||||-|||||--|||||||||-|  0 [P] COG0598 Mg2+ and Co2+ transporters
--|-|||---||-||--|||-|||--|||||||-||||-|--|||||-||||||||---|||||--  0 [R] COG0637 Predicted phosphatase/phosphohexomutase
|-|---|-|----|---|||------|||-|----||--------------|--|----|------  0 [P] COG0798 Arsenite efflux pump ACR3 and related permeases
-|-||||----------|-|||----------|--|-|----|||||-|-|-||-|||-|||||--  0 [L] COG0863 DNA modification methylase
--|---|-|-|--||--|--------||--||----------|||||-|-||--------------  0 [C] COG1085 Galactose-1-phosphate uridylyltransferase
------|---------|||||||||-|||||--|||||--||||||||||||||||||||||||--  0 [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase
|--||||-|--|-|---|--||-----||-|-|-|-||-------||-||-----|---|||||--  0 [Q] COG1228 Imidazolonepropionase and related amidohydrolases
--|---|---||-|||||-|-|----|--||||||||-----|||||--|-|||||--||||||--  0 [P] COG1230 Co/Zn/Cd efflux system component
--||--|-|-|--||-|----|||--||||----||||-------|---------|-------|--  0 [H] COG1232 Protoporphyrinogen oxidase
-||||||-|-||||||--||-|--------------------------||-----|---||-||--  0 [J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing
---|--|------|-------------||--------------------||-||||--|----|--  0 [S] COG1297 Predicted membrane protein
|||--||----------|---------||-------------------------------------  0 [L] COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||--||--|||-----|-|-------||-------------------------------------  0 [L] COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||--||-||||----||---------||--------|----------------------------  0 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs)
|-|---|---||----|-|--|-----------|--|-----|--|----------|||-------  0 [V] COG1401 GTPase subunit of restriction endonuclease
||---||--|-------|------------------------------------------------  0 [L] COG1421 Uncharacterized protein predicted to be involved in DNA repair
-|||--|----------|-||-----|---|----|--||---|||--|--|--|-|||-------  0 [S] COG1479 Uncharacterized conserved protein
-|---||---||----|-------------------------------------------------  0 [L] COG1517 Uncharacterized protein predicted to be involved in DNA repair
|||-|||-|||||---||-||------||---|--|-|----|||||----|--|---|-------  0 [L] COG1518 Uncharacterized protein predicted to be involved in DNA repair
------|------|-----|-------|||||---||--|--|||--------||-----------  0 [G] COG1554 Trehalose and maltose hydrolases (possible phosphorylases)
||----|----------|||--------------------------------------------||  0 [P] COG1563 Predicted subunit of the Multisubunit Na+/H+ antiporter
|||--||----------|---------||-------------------------------------  0 [L] COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|-----|---------|-------------------------------------------------  0 [S] COG1700 Uncharacterized conserved protein
----|||-|-|-|||---||-|-----------|---|----------|--|----|||||||---  0 [E] COG1748 Saccharopine dehydrogenase and related proteins
-|----|-|---------------------------------------------------------  0 [R] COG1800 Predicted transglutaminase-like proteases
|||||||-|-|-------------------------------------------------------  0 [S] COG1860 Uncharacterized protein conserved in archaea
|-----|------------------------|--|||------------|--|-------------  0 [M] COG1887 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC
-||---|-|--------|------------------------------------------------  0 [S] COG1895 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
-----||---|-------||-|----|||-|-||||||----|||||-||--|--|---|||||--  0 [L] COG1961 Site-specific recombinases, DNA invertase Pin homologs
-||---|-|---|-----|||------||----|--------|--||-|------|---||-----  0 [JD] COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system
-||---|---||------||-|--------------||----|||||-||-----|----------  0 [S] COG2105 Uncharacterized conserved protein
---|--|--|--|---|----|---|-------|||||---------------------||||---  0 [E] COG2309 Leucyl aminopeptidase (aminopeptidase T)
------|----||-----||-------||-----------------------|-------------  0 [S] COG2442 Uncharacterized conserved protein
|||---|-|---|------------------|-----|----------|-----------------  0 [R] COG3291 FOG: PKD repeat
------|----|-----------------------|-|---------------------|--|---  0 [S] COG3535 Uncharacterized conserved protein
------|---||------||-------||-------------------------------|-----  0 [R] COG4113 Predicted nucleic acid-binding protein, contains PIN domain
------|------||--------------------------------------------||-|---  0 [E] COG4126 Hydantoin racemase
--|---|------------------------------------------|-----|----------  0 [S] COG4273 Uncharacterized conserved protein
------|----||-----------------------------------------------------  0 [S] COG4342 Uncharacterized protein conserved in archaea
----|||----|------------------------------------------------------  0 [S] COG4344 Uncharacterized protein conserved in archaea
|||---|-|-------||--|---|-------|-------------|-||-|------|-------  0 [C] COG5016 Pyruvate/oxaloacetate carboxyltransferase
------|-|-|-------|-------|---------|-----------------------------  0 [S] COG5428 Uncharacterized conserved small protein