(Mka) Methanopyrus kandleri AV19 Functional categories Fun All J A K L B D Y V T M N Z W U O C G E F H I P Q R S COGs 1,022 152 2 41 49 3 10 -  5 9 20 2 -  -  16 37 74 28 89 43 85 14 31 6 168 180 proteins 1,297 170 2 53 69 5 19 -  6 14 27 3 -  -  17 47 125 36 113 48 104 19 38 14 241 200 Distribution of COGs by number of proteins proteins 1 2 3 4 5 6 7 8 10 11 13 COGs 867 108 22 13 2 1 2 4 1 1 1

Co-ocurrences in sister taxa No sister genomes in order Methanopyrales

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
|||-|||||||||----|||||--------|-----|-----|||||-|||||||||||||-|--- 13 [C] COG1145 Ferredoxin
|||||||||||||||-||||||||-|||||||||||||----|||||-|||||||||||||||||| 11 [R] COG0517 FOG: CBS domain
-|-|--||||||||||-|||||||--|||-||||||||----|||||-||||||||--||||||-- 10 [J] COG0144 tRNA and rRNA cytosine-C5-methylases
|||||||||||||||||||||||||-||||||||||||----||||||||||||||||||||||||  8 [QR] COG0500 SAM-dependent methyltransferases
-|--||||-|--||--|-||-|-----|||------|-----------------------------  8 [L] COG1372 Intein/homing endonuclease
||||-----|--------||-------||--------------------|-----|---||||---  8 [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases
|||------|------|-|-----------------------------------------------  8 [R] COG1719 Predicted hydrocarbon binding protein (contains V4R domain)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  7 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
|||-|||||||||----|||||-----||-||-----|----|||-|-||------------|---  7 [C] COG1032 Fe-S oxidoreductase
|||||||||||||---||||-|-----||-||--|-||-----------|-----|----|-|---  6 [R] COG0535 Predicted Fe-S oxidoreductases
|||||||||||||---||||||----|||||||-||||----|||||-||-|||||--||||||--  5 [K] COG0640 Predicted transcriptional regulators
|||-|||||||||---||--|------||-||||||------|||||-||||---|----------  5 [O] COG1180 Pyruvate-formate lyase-activating enzyme
|||-||-||||||||-||||-|----||||||-|||||----||||||||||||||--||||||--  4 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
||||--||-|-------|||||----||||||||||||||||--------------||||||||||  4 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily
|||-----||--------||----------------------------------------|-----  4 [C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit
||||||-|||||-----|||-|----|||||-----------|||-|-||--|--|||||||||||  4 [C] COG1146 Ferredoxin
||||||||||-|||--||||-|----|||-||---|||||--|||||-|||-||||||||||||||  4 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component
|-|---||||||----||||-|-----||||----|||-----------||||--|---||-||--  4 [E] COG1305 Transglutaminase-like enzymes, putative cysteine proteases
|||---|||||||---||------------|---|-----------|---|--------||----|  4 [R] COG1708 Predicted nucleotidyltransferases
------||||--|----|------------------------------------------|-----  4 [L] COG1743 Adenine-specific DNA methylase containing a Zn-ribbon
||----||||||||----------------------------------------------------  4 [R] COG1818 Predicted RNA-binding protein, contains THUMP domain
|--------|-------|--|---------|-||-|||----------------------------  4 [R] COG1827 Predicted small molecule binding protein (contains 3H domain)
|||---||||--------||----------------------------------------------  4 [C] COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit
-|----|||||||----|------------------------------------------------  4 [S] COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN
|||---||||--------||----------------------------------------------  4 [C] COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit
|||||||||||||||-||||-|----||||||--||||----|||||-|||||--|||||||||--  3 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
|||--|||||||-||-||||-|----|||||--|||||----||||||||||||||--||||||--  3 [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  3 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
||||||||||||||||||||||---||||||||||||||||||||||-||||||||||||||||||  3 [M] COG0463 Glycosyltransferases involved in cell wall biogenesis
|||||||||||||||||||||||||-||||-|||||||||||||||||||||||||||||||||||  3 [L] COG0470 ATPase involved in DNA replication
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  3 [GEPR] COG0477 Permeases of the major facilitator superfamily
|||||||||||||-|-|-||-|----||||-|||||||----|||||-||||-|||---|||||||  3 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins
||||||||||||----|||||||||||---||||||||----|||||-||||||||||||||||||  3 [L] COG0608 Single-stranded DNA-specific exonuclease
||||--||-|-|-||||-||||--|-||||||||||||----|||||-|||||--|||-|||||||  3 [I] COG0671 Membrane-associated phospholipid phosphatase
|||------|-|----|--|||--------||||||||----|||||-||||-|||||||||----  3 [O] COG0826 Collagenase and related proteases
|||---||||-------|------------|---------------|-------------------  3 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II
||||||||||------||--||--||----|||||||||-|||||-|---------|||||-----  3 [R] COG1418 Predicted HD superfamily hydrolase
|||---||-|--------||-|--------|-----------------------------------  3 [C] COG1625 Fe-S oxidoreductase, related to NifB/MoaA family
--|------|---||---||----------------|-----------------------------  3 [I] COG1657 Squalene cyclase
--|---|||||||---|||||||||||||-||--||||----|||||-|||||------|||||-|  3 [R] COG1694 Predicted pyrophosphatase
||||||||||--------------------|-----||----------------------------  3 [S] COG1873 Uncharacterized conserved protein
||||--||||---|||--------------------------------------------------  3 [B] COG2036 Histones H3 and H4
|||------|--------|-----------------------------------------------  3 [R] COG2144 Selenophosphate synthetase-related proteins
-|-------|-------|--||---------------------------------|----------  3 [G] COG2342 Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase
-|-------|---------|----------------------------||----------|-|---  3 [S] COG3287 Uncharacterized conserved protein
|--|||---|-------|-|----------------------------------------|-----  3 [S] COG3367 Uncharacterized conserved protein
-------|-|--------------------|-----------------------------------  3 [S] COG5617 Predicted integral membrane protein
||||||||||||||||||||-|----||||||--|||-----|||||-||--||||||||||||--  2 [G] COG0063 Predicted sugar kinase
||||--||||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  2 [E] COG0065 3-isopropylmalate dehydratase large subunit
|||---||||||-||-||||-|----||||||-|||||----||||||||||||||--||||||--  2 [E] COG0066 3-isopropylmalate dehydratase small subunit
||||--||||--||----||-------||--|---|-|----||||--|-|---------|||---  2 [E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
||||---|-||--||--|||-|||--||||||||||||----|||-|-||-|-|||--||||||-|  2 [R] COG0110 Acetyltransferase (isoleucine patch superfamily)
-||--|--|||||||-|-||-------|-------|-|------------------||-|||||--  2 [EQ] COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit
-||||-||-||||||---||||----|||-|-----||----||||||||--||||---|||||--  2 [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  2 [L] COG0177 Predicted EndoIII-related endonuclease
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0195 Transcription elongation factor
||||||--|||||---|-||||----||||-|----||----|||||-||||-||||||||||---  2 [C] COG0247 Fe-S oxidoreductase
||||||--||---|||--------||----------------||||||||||||||---|||||||  2 [J] COG0293 23S rRNA methylase
|||||||||||||----|------|-----|||||||||||||||||-||||--------------  2 [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase
|||-|||||||||---||||-|-----||-|------|----||||||||||||||---|||||--  2 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs
||||--||||---|||---|||||||||-|||||||||||--||||||||||-||||||-------  2 [S] COG0327 Uncharacterized conserved protein
|||-----||------||||-|----|||-||---||-----|||||-||||||||---|||||--  2 [E] COG0347 Nitrogen regulatory protein PII
|||-----||----|-|-||||----|||-----|--||---|||||--||----||||||||---  2 [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase
||||--||||------||||------|||||---|||-|||||||-|--|--|--|---||||---  2 [S] COG0392 Predicted integral membrane protein
|||||||||||||||-||||-|----|---|--|---|----|||||--||||--|||||||||--  2 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
||||||--||||----|||||-------------|-|-----||||||||||-|||--||||||--  2 [O] COG0425 Predicted redox protein, regulator of disulfide bond formation
||||||||||||||||||||||---|||||||||||||----|||||-||||||||||||||||||  2 [M] COG0438 Glycosyltransferase
||||||||||||||||--||-|----||||------||-----------|-----|--|||-|---  2 [O] COG0464 ATPases of the AAA+ class
||||||||||||||--||||---------------------------------------||-|---  2 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  2 [L] COG0468 RecA/RadA recombinase
|||---||||||-||-||||-|----||||||--||||----||||||||||||||--||||||||  2 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase
-|||--||||||||||--------------------------------------------------  2 [T] COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0480 Translation elongation factors (GTPases)
||||||||||||||||||||||----||||||||||||----||||||||||||||||||||||--  2 [R] COG0491 Zn-dependent hydrolases, including glyoxylases
||-|||||-|--|||-||||||-|-|||||||||||||----||||||||||||||||||||||--  2 [F] COG0516 IMP dehydrogenase/GMP reductase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0522 Ribosomal protein S4 and related proteins
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  2 [E] COG0527 Aspartokinases
||||||||||||-||-|||-----||-----------|----|||||-|--|--------|-----  2 [P] COG0530 Ca2+/Na+ antiporter
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [J] COG0532 Translation initiation factor 2 (IF-2; GTPase)
||------||------|-||||----||||||||||||----|||||-||||||||--||||||--  2 [K] COG0583 Transcriptional regulator
||||--|||||||||--|--|---|----|||||||||-||||||||-||----------------  2 [R] COG0622 Predicted phosphoesterase
-|--|||||||||||-||--||-|--||||||||||||----||||||||||||||||||||||||  2 [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases
||||||||||||||||-----------|||------------------------------------  2 [O] COG0638 20S proteasome, alpha and beta subunits
|||||||||||||||-|||||-----|||||-----------|||-|--|--||||---|||||--  2 [C] COG0644 Dehydrogenases (flavoproteins)
|||---||||------|||||------||-------||----|||||-||--||||||-|||||--  2 [G] COG0662 Mannose-6-phosphate isomerase
|||-||||-|-|----|-||-|----|||-|-----||----|||-|-||--||||--||||||||  2 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  2 [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit
|||---||||-|----|-||----------|-----------|||-|---------|||-------  2 [C] COG0680 Ni,Fe-hydrogenase maturation factor
-||||||||||||||-|-||||--||-||-|--|||||-||||||||-||-||--|--||||||--  2 [R] COG0693 Putative intracellular protease/amidase
|||||||||||||---|-||--||--|||||------|----||||||-|||||||||||||||||  2 [F] COG0717 Deoxycytidine deaminase
|||||||||||||---||||||----|--|||--||||----|||||-||||||||||||||||--  2 [R] COG0730 Predicted permeases
|||||||||||||||--||||---------|-------------------------|||-------  2 [C] COG0731 Fe-S oxidoreductases
|||||||||||||---||||||||||||||||||||||----|||||-||||||||||||||||||  2 [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1
|--------|------||||||||||||||||||||||----||||||||||||||||||||||||  2 [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  2 [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit
|||||||||||||---|||||---|--||-||--||-|----|||||-|------||||---||--  2 [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit
|||-----||--------------------------------------------------------  2 [C] COG1029 Formylmethanofuran dehydrogenase subunit B
-|||||||||||-------|----------------------|||||-||---||-----|-|---  2 [C] COG1042 Acyl-CoA synthetase (NDP forming)
||||||--|||-|---||||||||---||||------|----|||||-|-------|||-------  2 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes
||------||---------|----------------------------------------------  2 [R] COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold
|||||||||||||||||-||-|----------------------------------------|---  2 [R] COG1100 GTPase SAR1 and related small G proteins
|||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||  2 [G] COG1109 Phosphomannomutase
-|----|||||||---||------------------------------------------------  2 [L] COG1110 Reverse gyrase
|||-|----|-|------|||-----||||----|-------|||||-|------|||-||-|---  2 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase
||||----|||||---|||||||||||||-||||||||||||||||||||||||||||||||||||  2 [V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component
|||---||||-------|||----------------------|||||-------------------  2 [C] COG1142 Fe-S-cluster-containing hydrogenase components 2
|||-----||-|----||------------------------------------------------  2 [C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins
|||---||||-------|------------------------------------------------  2 [C] COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain
|||-----||--------------------------------------------------------  2 [C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit
||||||||||||||||----||||||------||--------------------------------  2 [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B
||-|-|||-|||----|-||-||||||||||----|||--|||||||-||--||||||||||||||  2 [D] COG1192 ATPases involved in chromosome partitioning
|||||||||||||||||-||-|----|||||-----||-------||--|--||||--||||||--  2 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)
||||||||||||||||--------------------------------------------------  2 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family
|-------||-|----||-------------------|----------------------------  2 [L] COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||--||-||||----||---------||--------|----------------------------  2 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs)
|||-||||||---||-||--||-----||-||--||||----|||||-|-----------|-----  2 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family
||||||||||||||||--------------------------------------------------  2 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
|-|---|||||-|||-|-||--||--||||||--|||-----|||||-||||---|---|||||--  2 [R] COG1409 Predicted phosphohydrolases
|||||||||||||-----------------------------------------------------  2 [R] COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
||--|||||||||-----------------------------------------------------  2 [K] COG1581 Archaeal DNA-binding protein
||||||||||--|-----------------------------------------------------  2 [J] COG1588 RNase P/RNase MRP subunit p29
|||----|||-|-----|-||---------|-----|---------------------|-------  2 [C] COG1592 Rubrerythrin
|||-----||-------|||------|---|-----------------------------------  2 [S] COG1641 Uncharacterized conserved protein
||------||--------------------------------------------------------  2 [S] COG1667 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  2 [J] COG1676 tRNA splicing endonuclease
|||||||||||||--|||-|-|----|||-|------|----|||-|--|-----|----------  2 [S] COG1690 Uncharacterized conserved protein
||||||||||||||||-----|-----------------------|---|----------------  2 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control
|||---||||-||-------|-----------|---------|||-|-|||---------------  2 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase
||||||--||||------||||-----||-|----|-|--------|--|-----|---||||---  2 [H] COG1797 Cobyrinic acid a,c-diamide synthase
|||-----||--------------------------------------------------------  2 [S] COG1810 Uncharacterized protein conserved in archaea
|-||--||||--|-----------------------------------------------------  2 [P] COG1824 Permease, similar to cation transporters
|||||||||||||||||-------------------------------------------------  2 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase
|||-----||--------||----------------------------------------------  2 [S] COG1900 Uncharacterized conserved protein
|||-----||--------------------------------------------------------  2 [C] COG1908 Coenzyme F420-reducing hydrogenase, delta subunit
|||-----||------||--|---------||---|------|||---------------------  2 [I] COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)
|||---||||--|-----------------|---||||----|||||--|-|--------------  2 [R] COG1988 Predicted membrane-bound metal-dependent hydrolases
||------||------|----|-----||------------------------||-----------  2 [R] COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid
|||-----||--------------------------------------------------------  2 [C] COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase
|||||||||||||-------------||--|--------------|---|-|---|---||-||--  2 [NU] COG2064 Flp pilus assembly protein TadC
||--||||-|-----------|--------------------------------------------  2 [G] COG2074 2-phosphoglycerate kinase
|||-----|||-------------------|---------------|-------------------  2 [C] COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits
|||||||||||||--|--------------------------------------------------  2 [J] COG2263 Predicted RNA methylase
------||||-||-----------------------------------------------------  2 [R] COG2413 Predicted nucleotidyltransferase
||||||||||||||||--------------------------------------------------  2 [R] COG2520 Predicted methyltransferase
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  2 [H] COG2896 Molybdenum cofactor biosynthesis enzyme
-|||----||-|------------------------------------------------------  2 [K] COG3355 Predicted transcriptional regulator
-|||----||--------------------------------------------------------  2 [S] COG3366 Uncharacterized protein conserved in archaea
|||-----||--------------------------------------------------------  2 [D] COG3640 CO dehydrogenase maturation factor
||-------|--------------------------------------------------------  2 [R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase
|||------|--------------------------------------------------------  2 [H] COG4058 Methyl coenzyme M reductase, alpha subunit
-|-------||||-----------------------------------------------------  2 [L] COG4080 RecB-family nuclease
---|||--||-||----|||||----||||||--||||----|||||--|-----|---|||||--  2 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily
----||---|----------------||||------------------------------------  2 [S] COG5650 Predicted integral membrane protein
||||||--|||||-|-|-||||||--|||||---||||----|||||-||-|||||||||||||--  1 [H] COG0001 Glutamate-1-semialdehyde aminotransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase
||-|||-|-||-|||-|-|||------|||-----|-|----------------------------  1 [P] COG0003 Oxyanion-translocating ATPase
|||-||--||-|-||-||||-|----|||-||--|||||---|||||--|--||||---|||||--  1 [P] COG0004 Ammonia permease
|||||||||||||||-||||-------||||-||-|||----|--||--|--|------||-|---  1 [F] COG0005 Purine nucleoside phosphorylase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [E] COG0006 Xaa-Pro aminopeptidase
||||||--|||||||-|-||||----|||||---||||----||||||||--||||---|||||--  1 [H] COG0007 Uroporphyrinogen-III methylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||---|||||||  1 [J] COG0009 Putative translation factor (SUA5)
|||||||||||||||---||||--------|-|-|-||----|||-|-||-|||||||-||||---  1 [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family
||-||||||||--|--|||-------|||-|--||-||----------------------------  1 [S] COG0011 Uncharacterized conserved protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0012 Predicted GTPase, probable translation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0013 Alanyl-tRNA synthetase
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0015 Adenylosuccinate lyase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit
||||||||||||||||--||||--||----|||||||||||||||||||-|||-------------  1 [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0018 Arginyl-tRNA synthetase
|||-||--||---||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0019 Diaminopimelate decarboxylase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [I] COG0020 Undecaprenyl pyrophosphate synthase
|||||||||||||||---||----------------------|||||-||||--------------  1 [J] COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [J] COG0024 Methionine aminopeptidase
||||||-|||---|||--||-|----|||--|-||||-----|||||-||-||------|--|---  1 [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0030 Dimethyladenosine transferase (rRNA methylation)
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase
-|||||||||-||||-|-||||----|||-||||---|----|||||-|-||-|||---|-|||--  1 [P] COG0038 Chloride channel protein EriC
||||||--|||||||-||||||||-|||||||||||||-||||||||-|-|||--|--||||||||  1 [C] COG0039 Malate/lactate dehydrogenases
||||----||||-||-||||-|----||||||--||||----|||||||||||||---||||||--  1 [E] COG0040 ATP phosphoribosyltransferase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
||||----||---|||||||||||||||||||||||||----|||||-||||||||||||||||||  1 [J] COG0042 tRNA-dihydrouridine synthase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases
|||||||||||||||-||||||----||||||||||||----|||-|--|--|--|||||||||--  1 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--||||||||  1 [C] COG0045 Succinyl-CoA synthetase, beta subunit
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0048 Ribosomal protein S12
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0049 Ribosomal protein S7
---------|---||-||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0050 GTPases - translation elongation factors
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0051 Ribosomal protein S10
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0052 Ribosomal protein S2
||||---||||||||-||||||---||||-||||||||----|||||-||-|---|--||||||||  1 [P] COG0053 Predicted Co/Zn/Cd cation transporters
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0054 Riboflavin synthase beta-chain
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||--  1 [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
|||----|||||-|--||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EH] COG0059 Ketol-acid reductoisomerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0060 Isoleucyl-tRNA synthetase
|||||||||||||||||||||---|||||||||||||||-||||||||||||||||||||||||||  1 [G] COG0061 Predicted sugar kinase
|||||||||||||||-||||-|----|||||-----------|||||-||--|--|||||||||--  1 [S] COG0062 Uncharacterized conserved protein
||||----||-||||-||||||||||||||||||||||||||-------|---|||||||||||||  1 [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0067 Glutamate synthase domain 1
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0068 Hydrogenase maturation factor
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0069 Glutamate synthase domain 2
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0070 Glutamate synthase domain 3
|||||||||||||||-||||-|-----||||---|-||----||||||||--|--|---|||||||  1 [O] COG0071 Molecular chaperone (small heat shock protein)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [R] COG0073 EMAP domain
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--||||||||  1 [C] COG0074 Succinyl-CoA synthetase, alpha subunit
||||||||||||||--||||-|--------||--|-||--------|-||------||-||-||--  1 [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase
||||||--||||-||-||||-|----||||||-|||||----|||-||||||||||--||||||--  1 [E] COG0077 Prephenate dehydratase
|||||||||||||||-||||-|---|||||||||||||--|-||||||||||||||--||||||--  1 [E] COG0078 Ornithine carbamoyltransferase
|||||||||||||||-||||||----||||||--||||----||||||||||||||--||||||--  1 [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0080 Ribosomal protein L11
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0081 Ribosomal protein L1
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0082 Chorismate synthase
-|-|||||-||||||-||||-|----||||||-|||||----|||||||-|||---|||-------  1 [E] COG0083 Homoserine kinase
|||---||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0084 Mg-dependent DNase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0087 Ribosomal protein L3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0088 Ribosomal protein L4
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0089 Ribosomal protein L23
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0090 Ribosomal protein L2
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0091 Ribosomal protein L22
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0092 Ribosomal protein S3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0093 Ribosomal protein L14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0094 Ribosomal protein L5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0096 Ribosomal protein S8
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0097 Ribosomal protein L6P/L9E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0098 Ribosomal protein S5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0099 Ribosomal protein S13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0100 Ribosomal protein S11
|||||||||||--||||||||||||||||||||||||||-||||||||||||||||||||||||||  1 [J] COG0101 Pseudouridylate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0102 Ribosomal protein L13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0103 Ribosomal protein S9
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0104 Adenylosuccinate synthase
|||||||||||||||||-||-||||||||||--|||||----|||||-||||||||||||||||||  1 [F] COG0105 Nucleoside diphosphate kinase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0107 Imidazoleglycerol-phosphate synthase
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase
||||||||||||||||||||-|||||||||||||||||-|||||||||||||||||||||||||||  1 [E] COG0112 Glycine/serine hydroxymethyltransferase
||||||--|||||||-|-||||||--|||||---||||----|||||-||-|||||||||||||||  1 [H] COG0113 Delta-aminolevulinic acid dehydratase
||||----|||--||-||||||----||||||||||||----|||||-||||||||||||||||||  1 [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
-|----|||||-|-----|-||--------||||||||----||||||||||||||----------  1 [L] COG0116 Predicted N6-adenine-specific DNA methylase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0118 Glutamine amidotransferase
||||||||||||||||--||-|||||----||||||------||||||||||||||---|||||--  1 [G] COG0120 Ribose 5-phosphate isomerase
||||--|||||||||||-||-|------------|-||----------||---|||---|||||--  1 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0124 Histidyl-tRNA synthetase
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [F] COG0125 Thymidylate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0126 3-phosphoglycerate kinase
||||||||||||||||||||||||||||||||||||||----|||||-||||||||--||||||--  1 [F] COG0127 Xanthosine triphosphate pyrophosphatase
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase
|||----||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase
||||||||||||||||||||||||||||||||||||||||--||||||||||||||--||||||||  1 [J] COG0130 Pseudouridine synthase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0131 Imidazoleglycerol-phosphate dehydratase
||||---|||---||-|||||||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0133 Tryptophan synthase beta chain
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0134 Indole-3-glycerol phosphate synthase
||||||-||||||||-||||-||---|---||-|||||----||||||||||||||||||||||--  1 [E] COG0135 Phosphoribosylanthranilate isomerase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0136 Aspartate-semialdehyde dehydrogenase
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0137 Argininosuccinate synthase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0139 Phosphoribosyl-AMP cyclohydrolase
||||-----|||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0141 Histidinol dehydrogenase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [H] COG0142 Geranylgeranyl pyrophosphate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0143 Methionyl-tRNA synthetase
-||--|---||||||-|-||-------|----------------------------||-|||||--  1 [EQ] COG0146 N-methylhydantoinase B/acetone carboxylase, alpha subunit
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0148 Enolase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0149 Triosephosphate isomerase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0150 Phosphoribosylaminoimidazole (AIR) synthetase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||||||||||--  1 [F] COG0151 Phosphoribosylamine-glycine ligase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||||  1 [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
||||----|||||||-||||||||||||||||||||||||||---|---|---|||||||||||||  1 [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases
||||--||||||-|--|||||-----|||||-||-|||----|||||-||||||||||-||-||--  1 [H] COG0157 Nicotinate-nucleotide pyrophosphorylase
||||||-||||||||-||||-||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0159 Tryptophan synthase alpha chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0162 Tyrosyl-tRNA synthetase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase
||||||||||||||||||||||||-|||||||||||||----|||||-||||||||||||||||||  1 [L] COG0164 Ribonuclease HII
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0165 Argininosuccinate lyase
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0167 Dihydroorotate dehydrogenase
||||--||||--|||-||||||--||------||||||-||||||||-||||-||---||||----  1 [P] COG0168 Trk-type K+ transport systems, membrane components
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0169 Shikimate 5-dehydrogenase
|||-|||||||--||||-||----||--------------------------------------||  1 [I] COG0170 Dolichol kinase
|||||||||||||||-||||||--||||||||||||||||||||||||||--||||||||||||--  1 [H] COG0171 NAD synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0172 Seryl-tRNA synthetase
|||||||||||||||-||||-|----||||-|||||||----|||||-||||||||||||||||||  1 [E] COG0174 Glutamine synthetase
|||||||||||||||---||-|----||||----||||----|||||-||-|-|||--||||||--  1 [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0180 Tryptophanyl-tRNA synthetase
||||||--|||||||-|-||||||--|||||---||||----||||||||-|||||||||||||||  1 [H] COG0181 Porphobilinogen deaminase
|||-|||||||||||-|||||---------------|------------|--|-------|-|---  1 [J] COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
||||||||||||||||--|-||---||||||||-||||----|||||-|||----|||-|||||||  1 [I] COG0183 Acetyl-CoA acetyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0184 Ribosomal protein S15P/S13E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0185 Ribosomal protein S19
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0186 Ribosomal protein S17
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0197 Ribosomal protein L16/L10E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0198 Ribosomal protein L24
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0199 Ribosomal protein S14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0200 Ribosomal protein L15
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0201 Preprotein translocase subunit SecY
||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit
||||||||||------||||||--||||||||||||||-|||||||||||||||||||||||||||  1 [D] COG0206 Cell division GTPase
|||-----||---|||----||----||||||||||||-|||||||||||||||||---|||||--  1 [F] COG0207 Thymidylate synthase
|--|-----||||||-|-|||||||-||||||-|||||--|||||||-||||||||||||||||||  1 [H] COG0212 5-formyltetrahydrofolate cyclo-ligase
|||||||||||||||--|--||----|||||--|||||------------||--------------  1 [H] COG0214 Pyridoxine biosynthesis enzyme
-|||--||||---|--||--|---------||||||||||||||||||||||||||||||||||||  1 [R] COG0218 Predicted GTPase
|-||||||-|-||||||-||||||--|||||----|-|||||||||||||||||||||||||||||  1 [C] COG0221 Inorganic pyrophosphatase
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG0226 ABC-type phosphate transport system, periplasmic component
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)
||||-||||||-|||-||-||------||||-||-|||-||-|||||-|||||--|||--||||||  1 [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  1 [H] COG0237 Dephospho-CoA kinase
-|||--||-|---||-||||-|----|||-|--|||||----|||||-||||||||||||||||--  1 [D] COG0239 Integral membrane protein possibly involved in chromosome condensation
||-||||||||||---|-||-|----|||-------||----|||||-||||---|||||||||--  1 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0244 Ribosomal protein L10
|||||||||||||-|-||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0250 Transcription antiterminator
|||||||||||||||-----||----||||||||||||----|||||-|||-||||||||-|----  1 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D
||------||------|||||-||--|||||---||||----||||||||||||||||||||||||  1 [E] COG0253 Diaminopimelate epimerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0255 Ribosomal protein L29
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0256 Ribosomal protein L18
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI)
|||---|||||||-----------------|-|||-|--||-|||-|-|-||--------------  1 [G] COG0269 3-hexulose-6-phosphate synthase and related proteins
||----||-||||-|---||------|---|-||--||||--|||-|-|-|-||||||--|-||--  1 [L] COG0270 Site-specific DNA methylase
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0284 Orotidine-5'-phosphate decarboxylase
||||||--|||||||-||||-|----||||||-|||||----|||||-||||||||||||||||--  1 [E] COG0287 Prephenate dehydrogenase
|||-----||------||||--||--|||-||-|||||----||||||||||||||||||||||||  1 [E] COG0289 Dihydrodipicolinate reductase
|||||||||||||||-||||||||--||||||||||||----|||||-||||||||||||||||-|  1 [H] COG0294 Dihydropteroate synthase and related enzymes
|||---||||--------||----------|-----------|||-|---|-----|||-------  1 [O] COG0298 Hydrogenase maturation factor
|||||||||||||---|-||-|----|||||---||||----|||||-||||---|||||||||--  1 [H] COG0303 Molybdopterin biosynthesis enzyme
||||||||||||-|---|-|-|||--|||||---||||----||||||||||-||||||||-|---  1 [P] COG0306 Phosphate/sulphate permeases
|||||||||||||---|-||----------|-----------|||-|---------|||-------  1 [O] COG0309 Hydrogenase maturation factor
||||----||--------||----------|----|----------|---|----------|----  1 [P] COG0310 ABC-type Co2+ transport system, permease component
|||||||||||||||--|---|----|||||--|||||------------||--------------  1 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [H] COG0315 Molybdenum cofactor biosynthesis enzyme
|||||||||||||---|||||-||--||||||||||||----||||||||||||||||||||||||  1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase
|||||||||||||||-||||||--||||||||||---|-|--||||||||||||||||||||||||  1 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0341 Preprotein translocase subunit SecF
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0342 Preprotein translocase subunit SecD
|||||||||||||-||||||||||-||---||||||||----||||||||||||||||||||||||  1 [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase
-||-||--||-|------||----------|-----------|||-|-||||-|||||||||||--  1 [C] COG0348 Polyferredoxin
||||||||||||||--||-||-|||-||||||-|||||-|--|||||-||||||||||||||||-|  1 [L] COG0350 Methylated DNA-protein cysteine methyltransferase
|||||||||||||||-||-|||--|-||||||||||||----|||||-||||||||||||||||--  1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0358 DNA primase (bacterial type)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0361 Translation initiation factor 1 (IF-1)
|||||||||||-||||----------||||||---|||----|||||-||--|-------|-|---  1 [E] COG0367 Asparagine synthase (glutamine-hydrolyzing)
|||||||||||||-----||||----|||-|----|-|----|||-|-||-----|---||||---  1 [H] COG0368 Cobalamin-5-phosphate synthase
|||---|||||-----||||-|--------||--||------|||||-||--|--||||----|--  1 [P] COG0370 Fe2+ transport system protein B
|||||||||||||-|--|||----------||||-|||----|||||-------------|-----  1 [C] COG0371 Glycerol dehydrogenase and related enzymes
||||||--|||||---|-||||||--|||||---||||----|||||-||-||||||||-------  1 [H] COG0373 Glutamyl-tRNA reductase
--|-----||------|--|----------|-----------|||-|---------|||-------  1 [C] COG0374 Ni,Fe-hydrogenase I large subunit
|||---||||------|-||-|--------------------|||-|---------|||-------  1 [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)
||||--||||||----|||||-----|||||----|||----|||||-||--||||||-||-||--  1 [H] COG0379 Quinolinate synthase
|||||||||||||||-|-||-|||--|||||------|----|||||-||-|||||||||||||||  1 [H] COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases
||||----||---|--||||-|----||||||||||||----|||||-|--|--------------  1 [S] COG0391 Uncharacterized conserved protein
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
||-----|-||-----||||----|-|||-|--|--|-----|||||-||-|-||||||-||||--  1 [M] COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0409 Hydrogenase maturation factor
||||||||||||||||---|----------------------|||||-||----------------  1 [L] COG0417 DNA polymerase elongation subunit (family B)
||||||||||||||||||||||--||----||--|||-----|||||-||----------------  1 [L] COG0419 ATPase involved in DNA repair
||||||||||||||||||||||--||||||||--||||----|||||-||----------|-----  1 [L] COG0420 DNA repair exonuclease
-|--|||||||||||-||---|----|---|--|--||----||||||-|--||||||----|---  1 [E] COG0421 Spermidine synthase
||||---|||||----||||||----|||||-----||----|||||-||--||||--|||-||--  1 [H] COG0422 Thiamine biosynthesis protein ThiC
||||||||||||||||-----|--|||||||---|---||||------------------------  1 [J] COG0423 Glycyl-tRNA synthetase (class II)
||||--|||||||||||--|----------------------|||-|--|-----|----------  1 [A] COG0430 RNA 3'-terminal phosphate cyclase
|||---|||||||-|-||||-|-----||-|-----||----|||-|-||---------||-----  1 [S] COG0432 Uncharacterized conserved protein
|||||||||||||---||||-|-----||---|----|----||||---|-|---|---|||||--  1 [R] COG0433 Predicted ATPase
-|-|--|||||-|-----||----------------------|---|------------|--|---  1 [R] COG0434 Predicted TIM-barrel enzyme
|||||||||||||||-|||||||||-||||||||||||----|||||-||||||||||||||||||  1 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase
|||---||||--|||-||||-|----||||||-|||||----||||||||||-|||--||||||--  1 [E] COG0440 Acetolactate synthase, small (regulatory) subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0441 Threonyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0442 Prolyl-tRNA synthetase
|||||||||||||||-||||||--|||||-||||||-|-||||||||-||-|---|---|||||--  1 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases
||||||||-||||||||||||||||-||||||||||||----||||||||||||||||||||||--  1 [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
||||||||||||-||-||||||---|||||||-|||||----|||||-||||||||||||||||--  1 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases
|||||||||||||||-||||||---|||||||||||||----|||||-||||||||||||||||--  1 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase
||-|--||||------||-|----||-||||-----||----------||-----||||-------  1 [D] COG0455 ATPases involved in chromosome partitioning
||||||||||||||||||||||----|||||||||||||---|||||-||||||||--||||||--  1 [R] COG0456 Acetyltransferases
||||||||||||||||||||||||||||||||||||||--||||||||||||||||||||||||||  1 [O] COG0459 Chaperonin GroEL (HSP60 family)
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0460 Homoserine dehydrogenase
|||||||||||||||-||||||-|--||||||||||||----||||||||||||||||||||||--  1 [F] COG0461 Orotate phosphoribosyltransferase
|||||||||||||||-||||||--||||||||||||||||||||||||||||||||||||||||-|  1 [FE] COG0462 Phosphoribosylpyrophosphate synthetase
||-|--||-||--||-|-|--|||--|---|||||-||----|||||-||||||||||||||----  1 [P] COG0471 Di- and tricarboxylate transporters
||----||-|||-||-||||||||||||||||||||||----|||||||||||||||||||||-||  1 [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||||||||||||  1 [C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit
||||--||||||||--||||-|---|||||-|||||||----|-||||||||||||--||||||||  1 [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
||||||||||||||||||||||----|||||--|||||----|||||-||||||||||||||||||  1 [D] COG0489 ATPases involved in chromosome partitioning
||||||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0492 Thioredoxin reductase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0495 Leucyl-tRNA synthetase
||||----|||-||--||||-||||-----------------|||||-||||||||||||||||--  1 [R] COG0496 Predicted acid phosphatase
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0498 Threonine synthase
|||||||||||||||-||||------||||-------------------|--|--|---|||||--  1 [H] COG0499 S-adenosylhomocysteine hydrolase
|||||||||||||||||-||||----|||||-||-|||----||||||||||||||||||||||--  1 [O] COG0501 Zn-dependent protease with chaperone function
|||------|---||-|||||--|--|||||---|-||----||||||||||||||||||-|||--  1 [H] COG0502 Biotin synthase and related enzymes
||||--||-||||||--|||||--|||||-||||||||||||||||||||||-||||||||||---  1 [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
||||||||||||||||||||-|||||||||||||||||||--||||||||||||||||||||||||  1 [F] COG0504 CTP synthase (UTP-ammonia lyase)
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  1 [EF] COG0505 Carbamoylphosphate synthase small subunit
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0518 GMP synthase - Glutamine amidotransferase domain
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0519 GMP synthase, PP-ATPase domain/subunit
|-||--||-|-||-|--||||||||||||||||||||||||||||||-|||||--|||||||||--  1 [E] COG0520 Selenocysteine lyase
|||||||||||||---|--|-|----|||||---||||----|||||-||||---|||||||||--  1 [H] COG0521 Molybdopterin biosynthesis enzymes
|||||||||||||||--|||-|----||||||||||||----|||||-|||||--|---|||||--  1 [G] COG0524 Sugar kinases, ribokinase family
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0525 Valyl-tRNA synthetase
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0528 Uridylate kinase
||||||--||||||||--|||-||--|||||||||||||||||||||-|||||--|---|||||||  1 [E] COG0531 Amino acid transporters
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0533 Metal-dependent proteases with possible chaperone activity
|||||||||||||||-||||||----||||||||||||----||||||||--||||||||||||--  1 [F] COG0540 Aspartate carbamoyltransferase, catalytic chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0541 Signal recognition particle GTPase
|||-||||||-|-||-||--|---|-|||-||-|-|||----|||||-||---|||---|----||  1 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0547 Anthranilate phosphoribosyltransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||-|  1 [E] COG0548 Acetylglutamate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0550 Topoisomerase IA
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0552 Signal recognition particle GTPase
||||||||||||------||-|-----||-|------|----|||||-||||||||---|||||--  1 [O] COG0555 ABC-type sulfate transport system, permease component
|||||||||||-|||-----|--|--||||||----------|||||-||||||||||||||||--  1 [E] COG0560 Phosphoserine phosphatase
|-||||||||||||||-||||||||||||||||||||||||||||||||-||-|||---||-|---  1 [R] COG0561 Predicted hydrolases of the HAD superfamily
||||||--||-||-----||-|--------------------|||||-||||||||---|||||-|  1 [J] COG0565 rRNA methylase
||||--|||||-|---||||||--||-||---||||||-||||||||-||||-||---||||----  1 [P] COG0569 K+ transport systems, NAD-binding component
||||---||||||---||||-|---||||||||||||||-|||||||-|-|||--|--||||||--  1 [P] COG0573 ABC-type phosphate transport system, permease component
|||||||||||||---||||||--|-|||||--|-||-----|||||-||--||||||||||||||  1 [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [I] COG0575 CDP-diglyceride synthetase
||||----||||-----||||||||-|||-||||||||----|||||-||-|-|||--||||||--  1 [V] COG0577 ABC-type antimicrobial peptide transport system, permease component
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG0581 ABC-type phosphate transport system, permease component
|||||||||||||||||----|--------------------|||||-||||----|||-------  1 [S] COG0585 Uncharacterized conserved protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
|||-||--||-|-||--||--|----|||--|---|||-------|---||-||||---|||||--  1 [S] COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
-||-----||-------|||||||--|---|--||-||----||||---|||---|---|||||--  1 [P] COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
||||||||||||----|-|||---------||||||||----|||||-||||||||||||||||||  1 [O] COG0602 Organic radical activating enzymes
|||||||||||||---|-||----------|---|-||----|||||-||||||||||||||||||  1 [R] COG0603 Predicted PP-loop superfamily ATPase
|--------|------||||||---||||-|-----------|||||-||||||||||||||||-|  1 [O] COG0606 Predicted ATPase with chaperone activity
|||||||||||||---|-||------||||------||----||||||||||||||--|----|--  1 [H] COG0611 Thiamine monophosphate kinase
|||||||||||||||||--------------|--|||----------------------------|  1 [MI] COG0615 Cytidylyltransferase
-|||--|||||-|---||||||--|||||-||||||||||||------|-----------------  1 [R] COG0618 Exopolyphosphatase-related proteins
||||--||||-||----|||||----||||||||||||||||-||-|---|--------|||----  1 [P] COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
|||||||||||||||-||-----|--||||-|-|||||----||||||||||||||--||--||--  1 [E] COG0620 Methionine synthase II (cobalamin-independent)
|||||||||||||---||||||-||-|||||---|-||----||||||||||||||||||||||||  1 [J] COG0621 2-methylthioadenine synthetase
||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K
-|||||||||||||||-|||||--------||-|-|||----||||||||||||||--|||-||--  1 [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
|||--|||-|-|-----|---------||-------------|||-|-------------------  1 [C] COG0650 Formate hydrogenlyase subunit 4
|||-----||-|-||-|---||-----||||--|||||----||-||-||--|--|---|||-|-|  1 [R] COG0655 Multimeric flavodoxin WrbA
|||||||||||||-||||||||--|||||-||||||||----||||||||--||||||||||||||  1 [M] COG0668 Small-conductance mechanosensitive channel
|-||||||-|||-||-||||-|----|---||||||||----|||||-||-|---|||||||||--  1 [R] COG0673 Predicted dehydrogenases and related proteins
-|||||||-|||----||||-|---|-||-------------|||-|-----|---||--------  1 [L] COG0675 Transposase and inactivated derivatives
||-------|---||-|||||-----|---||--||||----||||--||-||--|--||||||||  1 [R] COG0679 Predicted permeases
||||||||||||||||||||||||||||||||||||||-|--||||||||||||||||||||||||  1 [U] COG0681 Signal peptidase I
|||-----||---|-------|----||||-------|----|||||-||||---|---||-|---  1 [H] COG0684 Demethylmenaquinone methyltransferase
||||----||---||-----||||---||||-----||----|||||-|||||||||||||||-||  1 [I] COG0688 Phosphatidylserine decarboxylase
|---|||||||||||||--|||----||||-----|||----|||||-||||||||---|||||||  1 [J] COG0689 RNase PH
|||-----||------||||-------||-|-||-|||----|||-------------|-------  1 [R] COG0701 Predicted permeases
|||||||||||||---||||-|---|||||||||||-||-|||||||-||--|--|---|||||--  1 [P] COG0704 Phosphate uptake regulator
-||||-|||||||||-||||-|--|-||||||||||||----|||||-|||||--|--||||||--  1 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
--|------|-|----||||||||||||||||||||||----||||||||||||||||||||||||  1 [M] COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase
-|-------|||----|-------------------------|||||--|||------|-|-----  1 [E] COG0709 Selenophosphate synthase
||||||-|||||-||-|-----||-------||||||-----|||-|------||-----------  1 [E] COG0710 3-dehydroquinate dehydratase
|||||||||||||---||||-|---||||||---||||----|||||-||--|--|---|||||--  1 [R] COG0714 MoxR-like ATPases
-||-----||---||--|||||||--|---|--||-||----||||--||||---|---|||||--  1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
|||-----||---||---|||---|-----||||-||-----|||||||||||--||||-------  1 [C] COG0716 Flavodoxins
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
||||||||||||----||||----------|---|-||----|||||-||||||||||||||||||  1 [H] COG0720 6-pyruvoyl-tetrahydropterin synthase
||||----||-||---||||||||||||||||||||||--||-------|---|||||||||||||  1 [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [P] COG0725 ABC-type molybdate transport system, periplasmic component
--|--|-|-|---|||-|||||||---|||||||||||----|||||-||--|--|||-|||||--  1 [G] COG0726 Predicted xylanase/chitin deacetylase
|||||||||||||---|-||-|----|||-----||||----|||||-||||--||||||||||--  1 [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A
|||------|------||||||||||||||||||||||----||||||||||||||||||||||||  1 [M] COG0770 UDP-N-acetylmuramyl pentapeptide synthase
|--------|------||||||||||||||||||||||----||||||||||||||||||||||||  1 [M] COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase
|||||--||||||---||||||----||||||||||||----|||||-||||||||||||||||--  1 [C] COG0778 Nitroreductase
|||---|||||||---|---|-||------|---|||-----|||||-||||||||||||||||||  1 [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation
|-|------|------|-||||||------------------|||||-||||||||||||||||||  1 [U] COG0811 Biopolymer transport proteins
|-||||||||||||||-|||-|----||||||||||||----|||||-||-||--|||-|||||--  1 [V] COG0842 ABC-type multidrug transport system, permease component
------||||||||||||--||----|||||-|-||||-|--|||||-||-|---||||----|--  1 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family
---------|------||--||--||----||||||||----||||||||||||||||||||||||  1 [D] COG0849 Actin-like ATPase involved in cell division
||||--|||||||-----------------|----|||----|||-|---------||---|-|--  1 [K] COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain
|||-----||-----------|---|----|----|||----|||--------------||||---  1 [F] COG1001 Adenine deaminase
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG1010 Precorrin-3B methylase
||||--||-|||-|||-|-|-|--|||||-||||||||----|||||-||-|-|||---|||||--  1 [R] COG1011 Predicted hydrolase (HAD superfamily)
||||||---||||||-|-||||----|||||||||||||---|||||-||-|-|||||||||||-|  1 [C] COG1012 NAD-dependent aldehyde dehydrogenases
|||||||||||--||---------------------------------------------------  1 [R] COG1019 Predicted nucleotidyltransferase
-|||--|||||-|----|------------------------------------------------  1 [C] COG1031 Uncharacterized Fe-S oxidoreductase
-|||--||||-------|------||-----------|-----------|--------|-------  1 [R] COG1033 Predicted exporters of the RND superfamily
|||-----||--------------------------------------------------------  1 [C] COG1036 Archaeal flavoproteins
|||||||||||||||---------------------------------------------------  1 [L] COG1041 Predicted DNA modification methylase
|||||||||||||-------||--|-----------------|||||-|||||||||||-------  1 [O] COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
|||---|||||||---|-||-|----||||||-|-|||-------|--||-----|---|||||-|  1 [F] COG1051 ADP-ribose pyrophosphatase
||-|||--|||||||-||||||||--||||||--||||----|||||-||||||||||||||||||  1 [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
||||||||||-------|------|-----|-----||----|||||-||||--------------  1 [O] COG1067 Predicted ATP-dependent protease
|---||--||------||-||-||||----|----|||----|||||-|||||--||||----|||  1 [D] COG1077 Actin-like ATPase involved in cell morphogenesis
|||||||||||||--|||--|----------||||||||-||------------------------  1 [R] COG1078 HD superfamily phosphohydrolases
|||---||||-|-----|||------|||||-|-||||----|||||--|-----|---|||||--  1 [G] COG1082 Sugar phosphate isomerases/epimerases
||||||||||||||||--------------------------------------------------  1 [R] COG1084 Predicted GTPase
-|----||-|--|---||--||||-------||||||-----||||||||||||||---||||---  1 [R] COG1092 Predicted SAM-dependent methyltransferases
||||||||||||||||--------------------------------------------------  1 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)
||||||||||||||||--------------------------------------------------  1 [R] COG1094 Predicted RNA-binding protein (contains KH domains)
||||||||||||||||--------------------------------------------------  1 [K] COG1095 DNA-directed RNA polymerase, subunit E'
|-|-|||||||||||---------------------------------------------------  1 [J] COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain)
|-|-||||||||||||--------------------------------------------------  1 [J] COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)
|||||||||||||-----------||----------------------------------------  1 [F] COG1102 Cytidylate kinase
|||-----||--------------------------------------------------------  1 [R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes
||||--||||--------------------------------------------------------  1 [L] COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain
||||||||||---||---------------------------------------------------  1 [L] COG1111 ERCC4-like helicases
|||||-||||-|-||||||-|------||||---|---|||||||-|--|--|---|--------|  1 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits
-||-||--||||-----|||||||--|---|--||-||----||||---||||--|---|||||--  1 [P] COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG1117 ABC-type phosphate transport system, ATPase component
||||--|||||||----|||||--|-||||||||||||||||-||-|-|-|----|---|||----  1 [P] COG1122 ABC-type cobalt transport system, ATPase component
|-||||||||||||||-|||-|---||||||||||||||||-|||||-||-|||||||-|||||--  1 [V] COG1131 ABC-type multidrug transport system, ATPase component
|||-||||||||----||--------------------------------------||--------  1 [C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit
|||-----||-|----|-------------------------------------------------  1 [C] COG1150 Heterodisulfide reductase, subunit C
|||----|||-------|--|---------|-----------|||||-------------------  1 [C] COG1151 6Fe-6S prismane cluster-containing protein
|||-----||--------------------------------------------------------  1 [C] COG1153 Formylmethanofuran dehydrogenase subunit D
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A
-||---||-|||||||-||||----|----||||||||||||------|----||-----------  1 [R] COG1161 Predicted GTPases
||||||||||||||||--------------------------------------------------  1 [R] COG1163 Predicted GTPase
||||----||---||-----|-||-|-||||-----||-----------|--|||||||||||-||  1 [I] COG1183 Phosphatidylserine synthase
|||||||||||||------|------|||-------------|||----|-----|---|||||--  1 [R] COG1201 Lhr-like helicases
||||--||-|--------------------------------------------------------  1 [R] COG1202 Superfamily II helicase, archaea-specific
|||||||||||||||||-------------------------|----------------||-----  1 [R] COG1204 Superfamily II helicase
|||---||||||-||----|-|----|||-------||-----||---------------|-----  1 [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
|-|-||||||||-||||-||------|---|||-||||----|||||--|-----|---|||||-|  1 [M] COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
||||--||||-|||||--------------------------------------------------  1 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit
|||-----||--------------------------------------------------------  1 [R] COG1223 Predicted ATPase (AAA+ superfamily)
------||||||||||--------------------------------------------------  1 [K] COG1224 DNA helicase TIP49, TBP-interacting protein
|||-----||--------------------------------------------------------  1 [C] COG1229 Formylmethanofuran dehydrogenase subunit A
||||||||||||||||-|||-|||||||||||||||||----|||-|----|---|------||--  1 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
||||||||||----|-|-|||-||||----||||||||----||||---|-----|---|||||||  1 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
-||------|------|-------------------------|||||-||||||||--||||||||  1 [S] COG1238 Predicted membrane protein
||||||--||--------||-|----|||--------------------|-----|----------  1 [H] COG1239 Mg-chelatase subunit ChlI
||||||---|--------||------|||--------------------|-----|----------  1 [H] COG1240 Mg-chelatase subunit ChlD
-|-------|------||--|---------|||-||||----|||||-|-----------------  1 [R] COG1242 Predicted Fe-S oxidoreductase
||||||||||||-|||-|--|---------|-----------------------------------  1 [KB] COG1243 Histone acetyltransferase
||||||||||--------------------|-----------------------------------  1 [R] COG1244 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
||||||--|||||||-||||||||--||||-|||||||-|||||||||||||||||---|||||||  1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
||||||||||||||||---------|-----|||||------------|-----------------  1 [I] COG1257 Hydroxymethylglutaryl-CoA reductase
|||||||||||||--|--------------------------------------------------  1 [J] COG1258 Predicted pseudouridylate synthase
|||---||-||-|---|---|-----------|--|||----|||||-||||-||||||-----||  1 [I] COG1267 Phosphatidylglycerophosphatase A and related proteins
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I
|||||||||||||-----||||-----||-|----|-|--------|-||-----|---||||---  1 [H] COG1270 Cobalamin biosynthesis protein CobD/CbiB
|-|-||--|||||----||--|----|---------||----|||||-|||||--|--||||||--  1 [E] COG1280 Putative threonine efflux protein
---------|-------|--|-||-|----||||||||||||------|----------|||----  1 [S] COG1284 Uncharacterized conserved protein
||||||||||||||||-|||||---|----||||||||------------------|||-------  1 [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP
|||---||||--|-----||-------||-|---|-||-----------|------------||--  1 [S] COG1300 Uncharacterized membrane protein
||||||||||-||-----------------------------------------------------  1 [S] COG1303 Uncharacterized protein conserved in archaea
|||||||||||||||---||-|--||||||-||||||-----|||||-||||-||----|||||||  1 [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
|||||||||||-||||--------------------------------------------------  1 [K] COG1308 Transcription factor homologous to NACalpha-BTF3
|-|||||||||||||||-||-|-----||--------------||||--|-----|----------  1 [R] COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily
||||||||||---|||--------------------------------------------------  1 [L] COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
|||---|||||-|---||------------|-----------------------------------  1 [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins
-|----|||||-|---||------------------------------------------------  1 [K] COG1318 Predicted transcriptional regulators
|||||||||||||----|---||||-||||||||||||----|||-|-----|---------|---  1 [K] COG1321 Mn-dependent transcriptional regulator
||-------|-------|--|---------||||||||-|--------------------------  1 [R] COG1323 Predicted nucleotidyltransferase
|-|-|||||||-|--|||-|-|-|------------------|||||-----|--|--------||  1 [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations
||||--|||||||-----------------------------------------------------  1 [J] COG1325 Predicted exosome subunit
||||--||||--------------------------------------------------------  1 [R] COG1326 Uncharacterized archaeal Zn-finger protein
|||---||-|-------|--|---------||||||------|||||-||||---|----------  1 [F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase
--|||||||||||||-||-|-|--|||||-||||||||----|||||-||--||||--||||||--  1 [Q] COG1335 Amidases related to nicotinamidase
|||--||--|||-----|-|-------||-------------------------------------  1 [L] COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||||||||||||-----------------------------------------------------  1 [KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon
|-|||||||||||-----------------------------------------------------  1 [S] COG1340 Uncharacterized archaeal coiled-coil protein
-|----|||||||||---------------------------------------------------  1 [R] COG1341 Predicted GTPase or GTP-binding protein
|||--|--||||-----|-||------||---|----|----------------------------  1 [L] COG1343 Uncharacterized protein predicted to be involved in DNA repair
|||------|--------|||---------|-----------------------------|-|---  1 [P] COG1348 Nitrogenase subunit NifH (ATPase)
|||-|||||||||||-||--------------------------------------------|---  1 [R] COG1355 Predicted dioxygenase
||||||||||||||||-|--|---------||||||||----------------------------  1 [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a)
||||--|||||-|----|-|||--------||||||||||--|||-|--|----------|-----  1 [G] COG1363 Cellulase M and related proteins
|||-----||---||-||||-|----||||||--||||-----------|---|||---|||||--  1 [E] COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase)
||----||-|--------------------------------------------------------  1 [R] COG1365 Predicted ATPase (PP-loop superfamily)
||||--||||-||||---------------------------------------------------  1 [J] COG1369 RNase P/RNase MRP subunit POP5
|||||||||||||-----------------------------------------------------  1 [O] COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit
|||||||||||||---||---------||-------------------------------------  1 [S] COG1371 Uncharacterized conserved protein
-|----||||--||||--------------------------------------------------  1 [J] COG1374 Protein involved in ribosomal biogenesis, contains PUA domain
|||||||||||||--------|--------------|-----------------------------  1 [K] COG1378 Predicted transcriptional regulators
|||---||-|--------------------------||----------------------------  1 [S] COG1379 Uncharacterized conserved protein
|||||||||||||||---------------------------------------------------  1 [O] COG1382 Prefoldin, chaperonin cofactor
||||||||||||||||--------------------------------------------------  1 [J] COG1383 Ribosomal protein S17E
||||||||||--|-----------||-----------------------------------|||||  1 [J] COG1384 Lysyl-tRNA synthetase (class I)
||||--|||||||-----------------------------------------------------  1 [L] COG1389 DNA topoisomerase VI, subunit B
|||||||||||-||||----||||||----------------------------------------  1 [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D
|||||||||||||-----------------------------------------------------  1 [K] COG1395 Predicted transcriptional regulator
||||||||||||||||--------------------------------------------------  1 [U] COG1400 Signal recognition particle 19 kDa protein
||-|-----||||----|||-------||------|-|---------------------|||||--  1 [R] COG1402 Uncharacterized protein, putative amidase
|||||||||||||----------------------------------------------|||||--  1 [R] COG1407 Predicted ICC-like phosphoesterases
|||-----||--------------------------------------------------------  1 [R] COG1411 Uncharacterized protein related to proFAR isomerase (HisA)
||||||||||||||||--------------------------------------------------  1 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
|---|||||||||-----------------------------------------------|-|---  1 [S] COG1415 Uncharacterized conserved protein
||------||--------------------------------------------------------  1 [S] COG1417 Uncharacterized conserved protein
||---||--|-------|------------------------------------------------  1 [L] COG1421 Uncharacterized protein predicted to be involved in DNA repair
||||||||||--------------------------------------------------------  1 [S] COG1422 Predicted membrane protein
|||---||||--|---|-------------------------------------------------  1 [L] COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III
||-|--||-||------|||----||--------------------------|--|---|||||--  1 [S] COG1430 Uncharacterized conserved protein
-|------||------|-------------------------------------------------  1 [J] COG1431 Uncharacterized protein containing piwi/argonaute domain
||||--||||------|-||-|--|-|---------------------||----|-||||||||--  1 [S] COG1432 Uncharacterized conserved protein
|||-|||||||------|------------|-----------------|-----------------  1 [S] COG1433 Uncharacterized conserved protein
||||||||||||||||----||--|--------|--------------------------------  1 [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F
||||--|||||||------------|----|--------------|---------|----------  1 [F] COG1437 Adenylate cyclase, class 2 (thermophilic)
||||||||||||||||--------------------------------------------------  1 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
---|--||||||||||--------------------------|||||-|-||--------------  1 [R] COG1444 Predicted P-loop ATPase fused to an acetyltransferase
|||-----||--------------------------------------------------------  1 [C] COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)
|||---||||--|---|-------------------------------------------------  1 [R] COG1458 Predicted DNA-binding protein containing PIN domain
|||||||||||||-----------------------------------------------------  1 [S] COG1460 DNA-directed RNA polymerase, subunit F
||||----||------|-------------------------------------------------  1 [E] COG1465 Predicted alternative 3-dehydroquinate synthase
||||||||||||||||--------------------------------------------------  1 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit
||||||||||--|----|----------------|-||-----------|--||||----------  1 [S] COG1469 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1471 Ribosomal protein S4E
||||----||------------||---|||--|---------------------------------  1 [S] COG1478 Uncharacterized conserved protein
------||||--|----|------------------------------------------|-----  1 [R] COG1483 Predicted ATPase (AAA+ superfamily)
--|||||||||||||-||||||--|||||-||||||||||||||||||||-|||||--|||||---  1 [H] COG1488 Nicotinic acid phosphoribosyltransferase
|||||||||||||-----------------------------------------------------  1 [J] COG1491 Predicted RNA-binding protein
||||||--||-|------||||-----||-|----|-|--------|-||-----|---|||||--  1 [H] COG1492 Cobyric acid synthase
---------|----------|---|-----||||||||||||----------||||---|||||--  1 [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism
||||||--||--------------------------------------------------------  1 [K] COG1497 Predicted transcriptional regulator
||||||||||||||||--------------------------------------------------  1 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog
||||||||||||||||--------------------------------------------------  1 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay
||||||||||||||||--------------------------------------------------  1 [J] COG1500 Predicted exosome subunit
|||||||||||||||||-------------------------------------------------  1 [J] COG1503 Peptide chain release factor 1 (eRF1)
|-|---||||--------------------------------------------------------  1 [S] COG1504 Uncharacterized conserved protein
|||-|||||||||---||-|-|----|---|---|-||----|||||--|-----|---|||||--  1 [J] COG1514 2'-5' RNA ligase
---||||||||||-|-||-|-|--------|-----|-----|||||-----|-------------  1 [L] COG1515 Deoxyinosine 3'endonuclease (endonuclease V)
|||-|||-|||||---||-||------||---|--|-|----|||||----|--|---|-------  1 [L] COG1518 Uncharacterized protein predicted to be involved in DNA repair
|||||||||||||--------|----|||-|-----||----|||||-||||-|||---|||||--  1 [K] COG1522 Transcriptional regulators
||-|--||-|---||-|--|------|-------|-|--|||-------|||-||---|||||---  1 [L] COG1525 Micrococcal nuclease (thermonuclease) homologs
|||||||||||--|||----||----------||--------------------------------  1 [C] COG1527 Archaeal/vacuolar-type H+-ATPase subunit C
---|--||-||||---|||||-||--|||||----|-|----||||||||||||||---|||||||  1 [J] COG1530 Ribonucleases G and E
||-----||||||-----------------------------------------------------  1 [S] COG1531 Uncharacterized protein conserved in archaea
||------||--------------------------------------------------------  1 [R] COG1532 Predicted RNA-binding protein
-||-|-|||||||----||-|------||-|-----||-----------|-----|---|||||-|  1 [L] COG1533 DNA repair photolyase
||||--||||-||-------|---------||||||||----|||||-||||||||----------  1 [J] COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
||||||||||||||||--------------------------------------------------  1 [R] COG1537 Predicted RNA-binding proteins
-|-------|------||------------------------------------------------  1 [S] COG1542 Uncharacterized conserved protein
|||||||||||||--------------||----------------------------------|--  1 [R] COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon
|||-----||--------------------------------------------------------  1 [KG] COG1548 Predicted transcriptional regulator/sugar kinase
||||||||||-|------------------------------------------------------  1 [J] COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain
||||||||||||||||--------------------------------------------------  1 [J] COG1552 Ribosomal protein L40E
|||------|-------|------------------------||||||||||--------------  1 [P] COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction
||||--||||||||||---------|-----|||||------------------------------  1 [I] COG1577 Mevalonate kinase
|||---|||||-----||------------------------------------------------  1 [S] COG1578 Uncharacterized conserved protein
||-|--||-||||----|||||----|||||-----------|||||-||-||------|||||--  1 [OU] COG1585 Membrane protein implicated in regulation of membrane protease activity
||||||--||||-||-|-||||||--|||||---||||----|||||-||-||||||||||||---  1 [H] COG1587 Uroporphyrinogen-III synthase
-|----|||||||||---------------------------------------------------  1 [S] COG1590 Uncharacterized conserved protein
||-|--|||||||-----------------------------------------------------  1 [L] COG1591 Holliday junction resolvase - archaeal type
||||||||||-|||||--------------------------------------------------  1 [L] COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
||||||||||||||||--------------------------------------------------  1 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain
|-|||||||||||-----------------------------------------------------  1 [S] COG1602 Uncharacterized conserved protein
||||--||||-||||---------------------------------------------------  1 [J] COG1603 RNase P/RNase MRP subunit p30
--------||-|----||-------------------|----------------------------  1 [L] COG1604 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
||||||--|||||||-||--||----||||||||||||----||||||||||||||||||||||--  1 [E] COG1605 Chorismate mutase
|||-----||-------|||----------|-----------------------------------  1 [R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily
|||||||||||||-----------------------------------------------------  1 [R] COG1608 Predicted archaeal kinase
--|-||||||||-|--||-|||||--||||-|--|-||----|||||-||-|||||--||||||--  1 [R] COG1611 Predicted Rossmann fold nucleotide-binding protein
|||-----||--------------------------------------------------------  1 [C] COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit
|||---||||--------------------------------------------------------  1 [S] COG1617 Uncharacterized conserved protein
|||-|||||||||---||------------------------------------------------  1 [F] COG1618 Predicted nucleotide kinase
---|----||-|---------|---|--------|-||----|||-|-||||-||||||--|----  1 [C] COG1620 L-lactate permease
-|||--||||------|-||-|||||----||||||||-|||------------------------  1 [S] COG1624 Uncharacterized conserved protein
||----||-|--------------------------------------------------------  1 [S] COG1627 Uncharacterized protein conserved in archaea
|||||||||||||--------|--------------------------------------------  1 [S] COG1628 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1631 Ribosomal protein L44E
||||||||||||||||--------------------------------------------------  1 [J] COG1632 Ribosomal protein L15E
|||||||||||||-----------------------------------------------------  1 [R] COG1634 Uncharacterized Rossmann fold enzyme
||||--|||||||||--|------------------------------------------------  1 [H] COG1635 Flavoprotein involved in thiazole biosynthesis
||-|--||-||||------|------||||------------------------------------  1 [L] COG1637 Predicted nuclease of the RecB family
||||||||||||||||--------------------------------------------------  1 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
-|||--|||||||-----------------------------------------------------  1 [R] COG1645 Uncharacterized Zn-finger containing protein
|||||||||||||---------------------||||----------------------------  1 [R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold
||||||--|||-|||-|---|------||-|---||||----||||||||--|||----|||||--  1 [H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)
-||||||||||||-----------------------------------------------------  1 [S] COG1650 Uncharacterized protein conserved in archaea
----|||||||||---||------|--||--------------------------|----------  1 [S] COG1656 Uncharacterized conserved protein
|-||||||||--|---------------------|--------||-|-|----------||-|---  1 [R] COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif
|||-----||-|------------------------------------------------------  1 [S] COG1665 Uncharacterized protein conserved in archaea
||||--||||||||||--------------------------------------------------  1 [K] COG1675 Transcription initiation factor IIE, alpha subunit
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1679 Uncharacterized conserved protein
||||||-||||||-----------------------------------------------------  1 [EH] COG1685 Archaeal shikimate kinase
|||-----||-------|||------|---|-----------------------------------  1 [R] COG1691 NCAIR mutase (PurE)-related proteins
|||-----||--------------------------------------------------------  1 [S] COG1693 Uncharacterized protein conserved in archaea
||||--||||||||||--------------------------------------------------  1 [L] COG1697 DNA topoisomerase VI, subunit A
|||-||||||-||-----------------------------------------------------  1 [S] COG1698 Uncharacterized protein conserved in archaea
||||--|||||||-----------------------------------------------------  1 [S] COG1701 Uncharacterized protein conserved in archaea
---------||-|---||||-|----||||-|||||||----|||||-||-|||||---|||||--  1 [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase
||------||--------------------------------------------------------  1 [R] COG1707 ACT domain-containing protein
-||||||||||||-----------------------------------------------------  1 [K] COG1709 Predicted transcriptional regulator
|||-----|||------|-------------------------------|-----|----------  1 [R] COG1712 Predicted dinucleotide-utilizing enzyme
|--------|--------||-------||||----|||----------|||--|||||||||||||  1 [S] COG1714 Predicted membrane protein/domain
||||||||||||||||--------------------------------------------------  1 [J] COG1717 Ribosomal protein L32E
||||--|||||||----|------------------------|||||-||||-||-------||--  1 [S] COG1720 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1727 Ribosomal protein L18E
|||||||||||||||-|-------------------------------------------------  1 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding
|||-----|||||-----------------------------------------------------  1 [H] COG1731 Archaeal riboflavin synthase
||||||||||||||||--------------------------------------------------  1 [J] COG1736 Diphthamide synthase subunit DPH2
||||----||--------------------------------------------------------  1 [R] COG1745 Predicted metal-binding protein
|||||||||||||-----------------------------------------------------  1 [J] COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme)
-|--||||||||||||--------------------------------------------------  1 [S] COG1756 Uncharacterized conserved protein
||||||||||||||||||||-|--||||||||||||||----|||||-||||||||||||||||||  1 [K] COG1758 DNA-directed RNA polymerase, subunit K/omega
|||---||||||------------------------------------------------------  1 [R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)
||||||||||||||||--------------------------------------------------  1 [K] COG1761 DNA-directed RNA polymerase, subunit L
|||||-|||||||---|-----------------||||----|||||-|-||---|--|||||---  1 [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein
-||-||||-|-||---||---|----|||-|----|-|--|||||||-||---|||---||-||--  1 [O] COG1765 Predicted redox protein, regulator of disulfide bond formation
-||---||||--------------------------------------------------------  1 [S] COG1772 Uncharacterized protein conserved in archaea
-|------||----------|---------|-----------|||---------------------  1 [E] COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB
|||-|||||||||||---------------------------------------------------  1 [R] COG1779 C4-type Zn-finger protein
|||||||||||||----|------------|-----------|||||||----||-----------  1 [F] COG1781 Aspartate carbamoyltransferase, regulatory subunit
|||||||||||||-----------------------------------------------------  1 [R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain
||||--||||--------------------------------------------------------  1 [S] COG1784 Predicted membrane protein
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1786 Uncharacterized conserved protein
||------||--------------------------------------------------------  1 [S] COG1790 Uncharacterized protein conserved in archaea
|||||||||||||||||----------||-------||----------|||--||---|||-||--  1 [L] COG1793 ATP-dependent DNA ligase
|||-----||-----------------------------------|--------------------  1 [S] COG1795 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1798 Diphthamide biosynthesis methyltransferase
||-------|----------------|---------|-----------------------------  1 [S] COG1809 Uncharacterized conserved protein
|||||||||||||---|---------------|---------------------------------  1 [E] COG1812 Archaeal S-adenosylmethionine synthetase
||||||||||||||||--------------------------------------------------  1 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1
||--|||||||||||--|---||---|----|-----------------|------------||--  1 [S] COG1814 Uncharacterized membrane protein
|||------|---|----|--|-----||||-----|------||||-||------------|---  1 [GC] COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
|||-----||--------------------------------------------------------  1 [R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)
--||||--|||||---|-||-|----||||----||||----|||||-||||||||||||||||||  1 [U] COG1826 Sec-independent protein secretion pathway components
||||||||||||----||||-|----||||-|--||||--------------------|-||||--  1 [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component
||||--|||||||-----------------------------------------------------  1 [R] COG1829 Predicted archaeal kinase (sugar kinase superfamily)
||||--||||-||---|--|--||------------------|||||----|-------||-|---  1 [G] COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes
|||||||||||-|-----------------------------------------------------  1 [R] COG1831 Predicted metal-dependent hydrolase (urease superfamily)
||||-|||||||-----|------------------------------------------------  1 [S] COG1833 Uncharacterized conserved protein
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain
||||||||||||||||||--||--||||||||||||||----||||||||||||||----||||||  1 [J] COG1841 Ribosomal protein L30/L7E
|||---||-|--------------------------------------------------------  1 [S] COG1844 Uncharacterized protein conserved in archaea
|||||||||||||----|-|||----||||||||||||----|||||-||--||||---|||||--  1 [K] COG1846 Transcriptional regulators
|||||||||||||-----------------------------------------------------  1 [S] COG1849 Uncharacterized protein conserved in archaea
|||||||||||||-----------------------------------------------------  1 [R] COG1855 ATPase (PilT family)
--|-|||||||-|||-----||--------------------|||----|---------|------  1 [J] COG1859 RNA:NAD 2'-phosphotransferase
-||||||||||||-----------------------||----------------------------  1 [S] COG1865 Uncharacterized conserved protein
|||----|||--|------|--||----|-------------|||||-|--|-------|--||||  1 [S] COG1872 Uncharacterized conserved protein
|||-----||--------------------------------------------------------  1 [C] COG1880 CO dehydrogenase/acetyl-CoA synthase epsilon subunit
-|||--||||--------------------------------------------------------  1 [S] COG1885 Uncharacterized protein conserved in archaea
||--|||||||||-----------------------------------------------------  1 [S] COG1888 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1889 Fibrillarin-like rRNA methylase
||||||||||||||||--------------------------------------------------  1 [J] COG1890 Ribosomal protein S3AE
|||-----||--------------------------------------------------------  1 [S] COG1891 Uncharacterized protein conserved in archaea
|-||--||||||------------------------------------------------------  1 [S] COG1892 Uncharacterized protein conserved in archaea
---|--|||||||||------|------------||------|||||-||-|----||||||||--  1 [R] COG1896 Predicted hydrolases of HD superfamily
||||||||||||||||---|-------------------------------------------|--  1 [O] COG1899 Deoxyhypusine synthase
-|||--|||||-|-----------------------------------|-----------------  1 [S] COG1901 Uncharacterized conserved protein
|||-||--||||------|||---------|----|----------|--|-----|---|-|----  1 [H] COG1903 Cobalamin biosynthesis protein CbiD
|||---||||-||-----------------------------------------------------  1 [R] COG1907 Predicted archaeal sugar kinases
|||-|||||||||-----------------------------------------------------  1 [S] COG1909 Uncharacterized protein conserved in archaea
|||---||||||||||--------------------------------------------------  1 [J] COG1911 Ribosomal protein L30E
-|||--|||||||---||-|-------------|||-------||-----------||--------  1 [S] COG1912 Uncharacterized conserved protein
-|-|--|||||||---|-------------------------------------------------  1 [R] COG1913 Predicted Zn-dependent proteases
||------||--------||----------------------------------------------  1 [S] COG1915 Uncharacterized conserved protein
||||--||||--------------||--------------------------|-------------  1 [S] COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein)
|||----|||-------||--|--------||--||------|||||-||--|--|-||----|--  1 [P] COG1918 Fe2+ transport system protein A
||||----||-----------------|||------------------------------------  1 [S] COG1920 Uncharacterized conserved protein
||--|----|------|-------------------------|||||--|||----|||||-|---  1 [E] COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]
|||-----||--------------------------------------------------------  1 [C] COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase
||||--|||||||-----------------------------------------------------  1 [S] COG1931 Uncharacterized protein conserved in archaea
||||||||||--------------------------------------------------------  1 [L] COG1933 Archaeal DNA polymerase II, large subunit
-||---||||--------------------------------------------------------  1 [S] COG1935 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)
|||||||||||||-----------------------------------------------------  1 [R] COG1938 Archaeal enzymes of ATP-grasp superfamily
||||-----|-----------------||-------------|||||--|||-------||-|---  1 [S] COG1944 Uncharacterized conserved protein
||||||||||------------||------------------------------------------  1 [S] COG1945 Uncharacterized conserved protein
||||--||||||||||--------------------------------------------------  1 [L] COG1948 ERCC4-type nuclease
|||---|||||-----||------------|------|----|||||-||--||||-----||---  1 [C] COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain
|-||||||||||||||--------------------------------------------------  1 [K] COG1958 Small nuclear ribonucleoprotein (snRNP) homolog
|||-----||--------------------------------------------------------  1 [H] COG1962 Tetrahydromethanopterin S-methyltransferase, subunit H
|||-|||||||||--------------||-------------------------------------  1 [R] COG1964 Predicted Fe-S oxidoreductases
|--------|||----||||||---||||||||||-||----||||||||--||||--||||||--  1 [V] COG1968 Uncharacterized bacitracin resistance protein
|||-----||-|------------------------------------------------------  1 [O] COG1973 Hydrogenase maturation factor
||||||||||||||||--------------------------------------------------  1 [J] COG1976 Translation initiation factor 6 (eIF-6)
||--|||||||||---|-------------------------------------------------  1 [G] COG1980 Archaeal fructose 1,6-bisphosphatase
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis
||--||--|||||------------------------|----|||||-|-----------------  1 [S] COG1986 Uncharacterized conserved protein
||||--||||------||||-|----|||-||||||||----|||||-||||||||--|---||--  1 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
||||||||||||||||----------|---------------------------------------  1 [S] COG1990 Uncharacterized conserved protein
||----||-|--------------------------------------------------------  1 [S] COG1991 Uncharacterized conserved protein
||||--||-||||----|------------------------------------------------  1 [S] COG1992 Uncharacterized conserved protein
-||---||-|------||---------||--------------------------------|-|--  1 [S] COG1993 Uncharacterized conserved protein
||||||-||||||---||||-|-----||-|----|||----------|----|||||--|-||--  1 [R] COG1994 Zn-dependent proteases
|||||||||||||||---------------|-----------------------------------  1 [K] COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger)
||||||||||||||||--------------------------------------------------  1 [J] COG1997 Ribosomal protein L37AE/L43A
|||||||||||||||---------------------------------------------------  1 [J] COG1998 Ribosomal protein S27AE
||-------|-------|------------------------------------------------  1 [R] COG2000 Predicted Fe-S protein
||||||||||||||||--------------------------------------------------  1 [J] COG2004 Ribosomal protein S24E
|-|-----||||------------------------------|||||--|||---|--|||-||--  1 [R] COG2005 N-terminal domain of molybdenum-binding protein
||||||||||||||||--------------------------------------------------  1 [J] COG2007 Ribosomal protein S8E
||||||||||||||||--------------------------------------------------  1 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5
|-||||-|||-||----||--|--------|||----------------|------------||--  1 [S] COG2013 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2016 Predicted RNA-binding protein (contains PUA domain)
||--||||-||||------------------------------------------------|----  1 [F] COG2019 Archaeal adenylate kinase
||||||||||-|||||--------------------------------------------------  1 [J] COG2023 RNase P subunit RPR2
|||-----||--------------------------------------------------------  1 [J] COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type)
|||---||-|--------------------------------------------------------  1 [S] COG2029 Uncharacterized conserved protein
|||-||||||-||-----------------------------------------------------  1 [S] COG2034 Predicted membrane protein
|||||||||||||-----||||----|||||------|----|||-|-||-----|---|||||--  1 [H] COG2038 NaMN:DMB phosphoribosyltransferase
||||||---|-|-|||--------------------------------------------------  1 [S] COG2042 Uncharacterized conserved protein
|||-----||--------------------------------------------------------  1 [S] COG2043 Uncharacterized protein conserved in archaea
||------||||----|--------------------------------|----------------  1 [R] COG2044 Predicted peroxiredoxins
||--||---|-------|||-|--------|-----|------------------|----------  1 [HR] COG2045 Phosphosulfolactate phosphohydrolase and related enzymes
||||||||||--------------------------------------------------------  1 [R] COG2047 Uncharacterized protein (ATP-grasp superfamily)
|||-----||-|----|-||--------------------------------------|-------  1 [C] COG2048 Heterodisulfide reductase, subunit B
||||||||||||||||--------------------------------------------------  1 [J] COG2051 Ribosomal protein S27E
||||||||||||||||--------------------------------------------------  1 [J] COG2053 Ribosomal protein S28E/S33
|||-----||--------------------------------------------------------  1 [R] COG2054 Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases
||----||-|----------------|---|-----|-----|||-|--|||-------||||---  1 [C] COG2055 Malate/L-lactate dehydrogenases
||||||||||||||||--------------------------------------------------  1 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2
|||-----||--------------------------------------------------------  1 [E] COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase
|--------||||--------|-----||-------||----|||----------|---||-||--  1 [R] COG2068 Uncharacterized MobA-related protein
|||-----||--------------------------------------------------------  1 [C] COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein)
||-|||--||||------|||---------|----|----------|--|-----|---||||---  1 [H] COG2073 Cobalamin biosynthesis protein CbiG
||||||||||||||||--------------------------------------------------  1 [J] COG2075 Ribosomal protein L24E
|||||||||||||||-||------------|-----------------------------------  1 [S] COG2078 Uncharacterized conserved protein
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2082 Precorrin isomerase
||----||||--------------------------------------------------------  1 [S] COG2083 Uncharacterized protein conserved in archaea
||||----||---------|------|----|--------------------|--|---||-|---  1 [R] COG2085 Predicted dinucleotide-binding enzymes
||-|--|||||||-----------------------------------------------------  1 [S] COG2090 Uncharacterized protein conserved in archaea
|||||||||||||||---------------------------------------------------  1 [J] COG2092 Translation elongation factor EF-1beta
|||||||||||||-----------------------------------------------------  1 [K] COG2093 DNA-directed RNA polymerase, subunit E''
-||-|||||||||---|--|-||||-----------|-----||||||||-|||||--||||||--  1 [U] COG2095 Multiple antibiotic transporter
||||||||||||||||--------------------------------------------------  1 [J] COG2097 Ribosomal protein L31E
||||||--||--------------------------------------------------------  1 [S] COG2098 Uncharacterized protein conserved in archaea
-|----|||||-|-----------------------------------------------------  1 [R] COG2100 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB
||||||||||||||||--------------------------------------------------  1 [R] COG2102 Predicted ATPases of PP-loop superfamily
|--|--|||||||||---------------------------------------------------  1 [S] COG2106 Uncharacterized conserved protein
-|||--|||||||-----------------|-----------------------------------  1 [R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme
--|-||||||||||--||--||-----||---|-||------|||-|--|-----|------|---  1 [R] COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1
---------|---|------|---------|||||||-----|||||-||||--------------  1 [P] COG2116 Formate/nitrite family of transporters
|||||||||||||||---------------------------------------------------  1 [R] COG2118 DNA-binding protein
--|---||-|-|-|||-----|----||||----|-||----|--|-------------||||---  1 [S] COG2120 Uncharacterized proteins, LmbE homologs
|||-----||----------------------------------------------------|---  1 [S] COG2122 Uncharacterized conserved protein
|-|-||||||||||||--------------------------------------------------  1 [J] COG2123 RNase PH-related exoribonuclease
||||||||||||||||--------------------------------------------------  1 [J] COG2125 Ribosomal protein S6E (S10)
||||||||||-|||||--------------------------------------------------  1 [J] COG2126 Ribosomal protein L37E
|||---|||||||---|-------------------------------------------|-----  1 [R] COG2129 Predicted phosphoesterases, related to the Icc protein
--|-||||||---||--|--||--|-----||||||||-|--------|-----------------  1 [F] COG2131 Deoxycytidylate deaminase
|||---||||||||||--------------------------------------------------  1 [JA] COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain
||||----||||------||-|----|||-----|-||-----------------|----------  1 [S] COG2138 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2139 Ribosomal protein L21E
||||----||-|-------|-|----||||--||||||-|--|||||--|--|--|---|||||--  1 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
||||||||||||||||--------------------------------------------------  1 [J] COG2147 Ribosomal protein L19E
|||-||||-||||----|---|----||||-|||||||----|---------|--|---|||||--  1 [R] COG2151 Predicted metal-sulfur cluster biosynthetic enzyme
|||---||||||||||--------------------------------------------------  1 [J] COG2157 Ribosomal protein L20A (L18A)
|||-----||--------------------|-----------------------------------  1 [R] COG2158 Uncharacterized protein containing a Zn-finger-like domain
---|--||-|-||-----|-------|||-|---||-----------------------||-||--  1 [R] COG2159 Predicted metal-dependent hydrolase of the TIM-barrel fold
||----||-|||||||--------------|------|----------------------------  1 [J] COG2163 Ribosomal protein L14E/L6E/L27E
||||||||||-|||||--------------------------------------------------  1 [J] COG2167 Ribosomal protein L39E
---------|-------|--------||||||-|||||----||||||||||||||||||||||||  1 [E] COG2171 Tetrahydrodipicolinate N-succinyltransferase
||----||-|||||||--------------------------------------------------  1 [J] COG2174 Ribosomal protein L34E
-||---|||||||-|---------------------------------------------------  1 [J] COG2178 Predicted RNA-binding protein of the translin family
-|----||-|--------|--|---------------------------|-----|----|-|---  1 [O] COG2192 Predicted carbamoyl transferase, NodU family
|||-----||--------------------------------------------------------  1 [C] COG2218 Formylmethanofuran dehydrogenase subunit C
||||||||||||||||--------------------------------------------------  1 [L] COG2219 Eukaryotic-type DNA primase, large subunit
||||||||||||||---|||||----|||-|-||||||----|||||-||-||--|--|||||--|  1 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold
|-----||-|-------|--||--------|-||-||-----|||||--|--|------|||||--  1 [M] COG2222 Predicted phosphosugar isomerases
||-------|---||-|----|-----||------------------------||-----------  1 [R] COG2229 Predicted GTPase
|||-----||--------------------------------------------------------  1 [R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase
|-||--||||---||-|--|-------||-|-----||----|||-|-||--|----------|--  1 [R] COG2234 Predicted aminopeptidases
||||||||||||||||--------------------------------------------------  1 [J] COG2238 Ribosomal protein S19E (S16A)
||||||--||||------|||-----|||-|----|----------|--|-----|---||||---  1 [H] COG2241 Precorrin-6B methylase 1
||||||--||||------|||-----|||-|----|----------|--|---------||||---  1 [H] COG2242 Precorrin-6B methylase 2
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2243 Precorrin-2 methylase
||||||||||-|-----|-|||----|---||||||||----|||||-||||||||---|||||--  1 [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
---||||||||||-----||------||||||-||||-----|---|--|-----|------||--  1 [S] COG2246 Predicted membrane protein
-|----|||||||-----------------------------------------------------  1 [R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)
|||||||||||||||---------------------------------------------------  1 [J] COG2260 Predicted Zn-ribbon RNA-binding protein
-|||--||-||||---||||||||--||||||||||||----|||||-||-|||||---|||||--  1 [R] COG2262 GTPases
|||||||||||||-----------------------------------------------------  1 [H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase
||-|-----|---------|-|-----|||----|-------||||---|-----|--||||||--  1 [E] COG2303 Choline dehydrogenase and related flavoproteins
---|--|--|--|---|----|---|-------|||||---------------------||||---  1 [E] COG2309 Leucyl aminopeptidase (aminopeptidase T)
---------|--------||-|--------------------|||||-||||||||---|||||--  1 [O] COG2377 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases
---|||---|||-----|---|------------|-------|||||-||--|--|--|||||---  1 [R] COG2391 Predicted transporter component
------||||--|--------------------------------|--------------------  1 [R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain
|-----||-||-|-----|-----------------------------------------------  1 [R] COG2403 Predicted GTPase
|-------|||||-----------------------------------------------------  1 [S] COG2410 Uncharacterized conserved protein
------|||||-|-----------------------------------------------------  1 [S] COG2411 Uncharacterized conserved protein
--||||||||-||-----------------------------------------------------  1 [S] COG2412 Uncharacterized conserved protein
------|||||||-----------------------------------------------------  1 [S] COG2419 Uncharacterized conserved protein
|-||||--|||||||-----------|-------|----------|---|-----|---||||---  1 [E] COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog
-||------||||-----------------------------|||||-|-----------------  1 [R] COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain
------||-|--||----------------------------------------------------  1 [S] COG2428 Uncharacterized conserved protein
|-||--|||||||-----------------------------------------------------  1 [S] COG2433 Uncharacterized conserved protein
||||||||||--||||--------------------------------------------------  1 [U] COG2443 Preprotein translocase subunit Sss1
||||||||||--------------------------------------------------------  1 [S] COG2450 Uncharacterized conserved protein
------||-|--||||--------------------------------------------------  1 [J] COG2451 Ribosomal protein L35AE/L33A
|||---||-|-|------------------|-----------------------------------  1 [S] COG2454 Uncharacterized conserved protein
|||---||||-|------------------------------------------------------  1 [S] COG2457 Uncharacterized conserved protein
--|---||||||-----||-|---------||-----|----------|--------------|--  1 [R] COG2509 Uncharacterized FAD-dependent dehydrogenases
||----||-|---------|-------------------------|---|---||----|-|----  1 [S] COG2510 Predicted membrane protein
|||||||||||||-----------------------------------------------------  1 [J] COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain)
|-----||||--------------------------------------------------------  1 [R] COG2517 Predicted RNA-binding protein containing a C-terminal EMAP domain
||||--|||||||-|--|------------------------|||||-||--||||||||||||--  1 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase
||-||||||||||||-||--------||||------------------------------------  1 [J] COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases
-|----||-||-|---------------------------------------|-------------  1 [R] COG2521 Predicted archaeal methyltransferase
|||------|--------|||---------|-----------------------------|-|---  1 [C] COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains
---------||-------||-|----||||||--||||----|||||-||-----|---|||||--  1 [K] COG2771 DNA-binding HTH domain-containing proteins
-|----||-|-|-----|---|---------|||||||----||||||||||-------|||||--  1 [J] COG2813 16S RNA G1207 methylase RsmC
-||------||||-------------|---||-|-|-----------------||-----------  1 [S] COG2848 Uncharacterized conserved protein
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2875 Precorrin-4 methylase
|||||||||||||-----------------------------------------------------  1 [J] COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG2890 Methylase of polypeptide chain release factors
|||---||||--|-----------------------------------------------------  1 [S] COG2892 Uncharacterized protein conserved in archaea
-|-------|--|-----------------------------------|-----------------  1 [R] COG3044 Predicted ATPase of the ABC class
|||-----||-----------------|||------------|||||-||-|-|||----------  1 [H] COG3161 4-hydroxybenzoate synthetase (chorismate lyase)
|-||-----|--|---|--------------------------------|-----|----|-|---  1 [S] COG3174 Predicted membrane protein
||||----||--------------------------------------------------------  1 [H] COG3252 Methenyltetrahydromethanopterin cyclohydrolase
|||--|||-|-|---------------||-------------|||-|-------------------  1 [C] COG3260 Ni,Fe-hydrogenase III small subunit
|||--|||-|-|---------------|--------------|||-|-------------------  1 [C] COG3261 Ni,Fe-hydrogenase III large subunit
||||||--|||-------------------------------------------------------  1 [R] COG3269 Predicted RNA-binding protein, contains TRAM domain
|-||--||||--|-----------------------------------------------------  1 [S] COG3273 Uncharacterized conserved protein
-||-||---|-|----|-------------------------|||-|--|||------|-|-----  1 [J] COG3276 Selenocysteine-specific translation elongation factor
|||||||||||-||||--------------------------------------------------  1 [J] COG3277 RNA-binding protein involved in rRNA processing
-|----||-||-|-----------------------------------------------------  1 [S] COG3286 Uncharacterized protein conserved in archaea
|--|||--||||------------------------------------------------------  1 [S] COG3356 Predicted membrane protein
---|---|||||------------------------------------------------------  1 [K] COG3357 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon
||-|-----|--------------------------------------------------------  1 [F] COG3363 Archaeal IMP cyclohydrolase
|-||----||--------------------------------------------------------  1 [R] COG3364 Zn-ribbon containing protein
|-||----||--------------------------------------------------------  1 [S] COG3365 Uncharacterized protein conserved in archaea
---------||||-----------------|||---||--------|--|-----|------|---  1 [S] COG3382 Uncharacterized conserved protein
--||||--||--------------------------------------------------------  1 [S] COG3388 Uncharacterized protein conserved in archaea
||||||||||||||||---------|-----||||||--------|-----------------|--  1 [I] COG3425 3-hydroxy-3-methylglutaryl CoA synthase
--||||||-|||----|-||----------------------------------------------  1 [S] COG3431 Predicted membrane protein
-|-------|----------|---------||||||||----------------------|-----  1 [R] COG3481 Predicted HD-superfamily hydrolase
|--|-----|--------------------------------------||---------||||---  1 [R] COG3608 Predicted deacylase
|||-|||||||||---||---|--------------------------------------------  1 [G] COG3635 Predicted phosphoglycerate mutase, AP superfamily
||||||||||||||||--------------------------------------------------  1 [T] COG3642 Mn2+-dependent serine/threonine protein kinase
|--------|----------------|---||||||||----------------------------  1 [M] COG3764 Sortase (surface protein transpeptidase)
-|----||-|--|-----------------------------------------------------  1 [L] COG3780 DNA endonuclease related to intein-encoded endonucleases
-||-----|||---------------||||||-|-|-------------|---||-----------  1 [T] COG3830 ACT domain-containing protein
|||||||||||||---||||||--|-||||||||||||-||||||||-||-||--|--|||||---  1 [G] COG3839 ABC-type sugar transport systems, ATPase components
|-------||--------------------------------------------------------  1 [R] COG4001 Predicted metal-binding protein
|||------|--------------------------------------------------------  1 [R] COG4002 Predicted phosphotransacetylase
------||||--------------------------------------------------------  1 [S] COG4003 Uncharacterized protein conserved in archaea
--|-||--||--------------------------------------------------------  1 [S] COG4004 Uncharacterized protein conserved in archaea
---------||||-----------------------------------------------------  1 [S] COG4006 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [K] COG4008 Predicted metal-binding transcription factor
||-------|--------------------------------------------------------  1 [S] COG4009 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4010 Uncharacterized protein conserved in archaea
|-|-----||--------------------------------------------------------  1 [S] COG4012 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4013 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4014 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family
||-------|--------------------------------------------------------  1 [S] COG4016 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4017 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4018 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4019 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4020 Uncharacterized protein conserved in archaea
|-|------|---||---------------------------------------------------  1 [S] COG4021 Uncharacterized conserved protein
|||------|--------------------------------------------------------  1 [S] COG4022 Uncharacterized protein conserved in archaea
---|||---||-|-----------------------------------------------------  1 [U] COG4023 Preprotein translocase subunit Sec61beta
||-------|--------------------------------------------------------  1 [S] COG4024 Uncharacterized protein conserved in archaea
|-----||-|--------------------------------------------------------  1 [S] COG4025 Predicted membrane protein
|------|-|--------------------------------------------------------  1 [R] COG4026 Uncharacterized protein containing TOPRIM domain, potential nuclease
------||-|--|-----------------------------------------------------  1 [S] COG4027 Uncharacterized protein conserved in archaea
------||-|-||-----------------------------------------------------  1 [R] COG4028 Predicted P-loop ATPase/GTPase
|||------|--------------------------------------------------------  1 [S] COG4029 Uncharacterized protein conserved in archaea
|-------||--------------------------------------------------------  1 [S] COG4030 Uncharacterized protein conserved in archaea
--||----||--------------------------------------------------------  1 [R] COG4031 Predicted metal-binding protein
|||------|--------------------------------------------------------  1 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein
|||------|--------------------------------------------------------  1 [S] COG4033 Uncharacterized protein conserved in archaea
--------|||||-----------------------------------------------------  1 [S] COG4034 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4035 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4036 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4037 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4038 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4039 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4040 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4041 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4042 Predicted membrane protein
------||-|---------------------------|----------------------------  1 [S] COG4043 Uncharacterized conserved protein
--||--||-|--------------------------------------------------------  1 [S] COG4044 Uncharacterized protein conserved in archaea
|--------||||-----------------------------------------------------  1 [S] COG4046 Uncharacterized protein conserved in archaea
------||-||-|-----------------------------------------------------  1 [S] COG4047 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4048 Uncharacterized protein conserved in archaea
-|----||-|--------------------------------------------------------  1 [R] COG4049 Uncharacterized protein containing archaeal-type C2H2 Zn-finger
|||------|--------------------------------------------------------  1 [S] COG4050 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4051 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [R] COG4052 Uncharacterized protein related to methyl coenzyme M reductase subunit C
||-------|--------------------------------------------------------  1 [S] COG4053 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [H] COG4054 Methyl coenzyme M reductase, beta subunit
|||------|--------------------------------------------------------  1 [H] COG4055 Methyl coenzyme M reductase, subunit D
|||------|--------------------------------------------------------  1 [H] COG4056 Methyl coenzyme M reductase, subunit C
|||------|--------------------------------------------------------  1 [H] COG4057 Methyl coenzyme M reductase, gamma subunit
|||------|--------------------------------------------------------  1 [H] COG4059 Tetrahydromethanopterin S-methyltransferase, subunit E
|||------|--------------------------------------------------------  1 [H] COG4060 Tetrahydromethanopterin S-methyltransferase, subunit D
|||------|--------------------------------------------------------  1 [H] COG4061 Tetrahydromethanopterin S-methyltransferase, subunit C
|||------|--------------------------------------------------------  1 [H] COG4062 Tetrahydromethanopterin S-methyltransferase, subunit B
|||------|--------------------------------------------------------  1 [H] COG4063 Tetrahydromethanopterin S-methyltransferase, subunit A
|||------|--------------------------------------------------------  1 [H] COG4064 Tetrahydromethanopterin S-methyltransferase, subunit G
|||------|--------------------------------------------------------  1 [S] COG4065 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4066 Uncharacterized protein conserved in archaea
---------|--------------------------------------||----------------  1 [O] COG4067 Uncharacterized protein conserved in archaea
|-------||--------------------------------------------------------  1 [S] COG4068 Uncharacterized protein containing a Zn-ribbon
|||------|--------------------------------------------------------  1 [S] COG4069 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [O] COG4070 Predicted peptidyl-prolyl cis-trans isomerase (rotamase), cyclophilin family
||-------|--------------------------------------------------------  1 [S] COG4071 Uncharacterized protein conserved in archaea
-|----||-|--------------------------------------------------------  1 [S] COG4072 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4073 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase
||-------|--------------------------------------------------------  1 [S] COG4075 Uncharacterized conserved protein, homolog of nitrogen regulatory protein PII
||-------|--------------------------------------------------------  1 [R] COG4076 Predicted RNA methylase
||-------|--------------------------------------------------------  1 [S] COG4077 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4078 Predicted membrane protein
|||------|--------------------------------------------------------  1 [S] COG4079 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4081 Uncharacterized protein conserved in archaea
--||----||--------------------------------------------------------  1 [S] COG4083 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4084 Uncharacterized protein conserved in archaea
||-------|--------------------------||----------------------------  1 [R] COG4085 Predicted RNA-binding protein, contains TRAM domain
|--------|--------------------|--|--||----------------------------  1 [S] COG4086 Predicted secreted protein
|||------|--------------------------------------------------------  1 [R] COG4087 Soluble P-type ATPase
-|-------|---||---------------------------------------------------  1 [F] COG4088 Predicted nucleotide kinase
--|-----||||------------------------------------------------------  1 [S] COG4089 Predicted membrane protein
|||------|--------------------------------------------------------  1 [S] COG4090 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [H] COG4218 Tetrahydromethanopterin S-methyltransferase, subunit F
--|-----||--------------------------------------------------------  1 [S] COG4739 Uncharacterized protein containing a ferredoxin domain
|-|------|--------------------------------------------------------  1 [R] COG4740 Predicted metalloprotease
|-|------|---------------------------------------|----------------  1 [S] COG4744 Uncharacterized conserved protein
--||----||--------------------------------------------------------  1 [R] COG4801 Predicted acyltransferase
|-|------|--------------------------------------------------------  1 [R] COG4827 Predicted transporter
-||------|--------------------------------------------------------  1 [R] COG4887 Uncharacterized metal-binding protein conserved in archaea
-||------|--------------------------------------------------------  1 [S] COG4921 Uncharacterized protein conserved in archaea
---------||-|-------------------------|----------------------|----  1 [S] COG4933 Uncharacterized conserved protein
||----||-|----------------|||-|--------------|---|-||--|---||-||--  1 [U] COG4962 Flp pilus assembly protein, ATPase CpaF
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG4992 Ornithine/acetylornithine aminotransferase
---------||-|-----------------------------------------------------  1 [L] COG4998 Predicted endonuclease (RecB family)
---------||------|------------------------------------------------  1 [R] COG5014 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [J] COG5256 Translation elongation factor EF-1alpha (GTPase)
||||||||||||||||--------------------------------------------------  1 [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)
-||---||-||-------------------------------------------------------  1 [J] COG5270 PUA domain (predicted RNA-binding domain)
|-|------|--------------------------------------------------------  1 [R] COG5643 Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E