(Mth) Methanothermobacter thermautotrophicus Functional categories Fun All J A K L B D Y V T M N Z W U O C G E F H I P Q R S COGs 1,123 144 2 48 64 3 8 -  11 11 30 2 -  -  14 48 92 31 84 47 92 21 52 6 176 192 proteins 1,567 147 2 73 75 5 11 -  16 57 56 3 -  -  17 66 181 48 111 55 123 27 81 10 274 220 Distribution of COGs by number of proteins proteins 1 2 3 4 5 6 7 8 9 10 11 15 17 19 COGs 902 138 42 17 8 5 2 1 1 1 3 1 1 1

Co-ocurrences in sister taxa No sister genomes in order Methanobacteriales

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
|||-|||||||||----|||||--------|-----|-----|||||-|||||||||||||-|--- 19 [C] COG1145 Ferredoxin
|||||||||||||||-||||||||-|||||||||||||----|||||-|||||||||||||||||| 17 [R] COG0517 FOG: CBS domain
|-|---------------|||------||||----|-----------------------|||||-- 15 [T] COG3920 Signal transduction histidine kinase
|-||--|||----|||-|||-|--||-||-|----|||----|||||-|||||--|||||||||-- 11 [T] COG0784 FOG: CheY-like receiver
||||-----|--------||-------||--------------------|-----|---||||--- 11 [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases
|-||----|-----|-||||-|||-||||||----|||----|||||-||--|--|--||||||-- 11 [T] COG2202 FOG: PAS/PAC domain
||||||||||||||||||||||---|||||||||||||----|||||-|||||||||||||||||| 10 [M] COG0438 Glycosyltransferase
|||||||||--|-|||||||||||||----||||||||----|||||-||-|||||||||||||||  9 [R] COG0457 FOG: TPR repeat
||||||-|||||-----|||-|----|||||-----------|||-|-||--|--|||||||||||  8 [C] COG1146 Ferredoxin
|||||||||||||---||||||----|||||||-||||----|||||-||-|||||--||||||--  7 [K] COG0640 Predicted transcriptional regulators
|-|----------------------------------------------|---|||--|-------  7 [R] COG3271 Predicted double-glycine peptidase
|-||||--|-|||||||-||-|-----||--|--||||----|||||-||-||--||-||||||--  6 [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases
||||||||||||||||||||||---||||||||||||||||||||||-||||||||||||||||||  6 [M] COG0463 Glycosyltransferases involved in cell wall biogenesis
||||||||||||||--||||---------------------------------------||-|---  6 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction
||||||||||-|-----|-|||----|---||||||||----|||||-||||||||---|||||--  6 [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
|||------|--------|||---------|-----------------------------|-|---  6 [C] COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  5 [K] COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit
|||||||||||||||||||||||||-||||||||||||----||||||||||||||||||||||||  5 [QR] COG0500 SAM-dependent methyltransferases
|||||||||||||-|-|-||-|----||||-|||||||----|||||-||||-|||---|||||||  5 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins
|||||||||||||---|||||---|--||-||--||-|----|||||-|------||||---||--  5 [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit
|||-----||--------||----------------------------------------|-----  5 [C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit
||||||||||-|||--||||-|----|||-||---|||||--|||||-|||-||||||||||||||  5 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component
|-|---||||||----||||-|-----||||----|||-----------||||--|---||-||--  5 [E] COG1305 Transglutaminase-like enzymes, putative cysteine proteases
|-|------|--------------------------------------------------------  5 [R] COG5643 Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E
|||-||-||||||||-||||-|----||||||-|||||----||||||||||||||--||||||--  4 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
||||----||--------||----------|----|----------|---|----------|----  4 [P] COG0310 ABC-type Co2+ transport system, permease component
|||-----||------||||-|----|||-||---||-----|||||-||||||||---|||||--  4 [E] COG0347 Nitrogen regulatory protein PII
|||-|--------||||-|||-----||||||||-||||||||||||--|----------|||---  4 [P] COG0474 Cation transport ATPase
|||||||||||||||--|||-|----||||||||||||----|||||-|||||--|---|||||--  4 [G] COG0524 Sugar kinases, ribokinase family
|||||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||  4 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins
|||-||--||-|-||--||--|----|||--|---|||-------|---||-||||---|||||--  4 [S] COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  4 [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit
|||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||-------  4 [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit
|||---||||-------|||----------------------|||||-------------------  4 [C] COG1142 Fe-S-cluster-containing hydrogenase components 2
|||-|||||||||---||--|------||-||||||------|||||-||||---|----------  4 [O] COG1180 Pyruvate-formate lyase-activating enzyme
|||||||||-||-||-------------------------------------------|-------  4 [R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation
|-||---------|||--||--||||--------|-||----||-----|------------|---  4 [C] COG1413 FOG: HEAT repeat
|||----|||-|-----|-||---------|-----|---------------------|-------  4 [C] COG1592 Rubrerythrin
||||||||||--------------------|-----||----------------------------  4 [S] COG1873 Uncharacterized conserved protein
|||-----||--------------------------------------------------------  4 [S] COG2043 Uncharacterized protein conserved in archaea
|||---|-|---|------------------|-----|----------|-----------------  4 [R] COG3291 FOG: PKD repeat
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  3 [E] COG0069 Glutamate synthase domain 2
|||--|||||||-||-||||-|----|||||--|||||----||||||||||||||--||||||--  3 [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases
|-||||-------||-||||||||||||||||||||||||||||||||||||||||||||||||||  3 [L] COG0210 Superfamily I DNA and RNA helicases
|||||||||||||||-|-||-|||--|||||------|----|||||-||-|||||||||||||||  3 [H] COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases
||||--||||------||||------|||||---|||-|||||||-|--|--|--|---||||---  3 [S] COG0392 Predicted integral membrane protein
|||---|||-------|||||---------|-----------|||-|--|-----|----------  3 [C] COG0426 Uncharacterized flavoproteins
|||||||||||||---||||-|-----||---|----|----||||---|-|---|---|||||--  3 [R] COG0433 Predicted ATPase
|||||||||||||||-|||||||||-||||||||||||----|||||-||||||||||||||||||  3 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase
||||||||||||-||-||||||---|||||||-|||||----|||||-||||||||||||||||--  3 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases
|||||||||-||||||||||||||--|||||||||||||---|||||-||||||||||||||||-|  3 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  3 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  3 [GEPR] COG0477 Permeases of the major facilitator superfamily
|||------|---||-|||||--|--|||||---|-||----||||||||||||||||||-|||--  3 [H] COG0502 Biotin synthase and related enzymes
|||||||||||||---||||-|-----||-||--|-||-----------|-----|----|-|---  3 [R] COG0535 Predicted Fe-S oxidoreductases
|-||--|||----|--|-||-|--|||||-|||||||||---|||||-||||||||||||||||--  3 [R] COG0546 Predicted phosphatases
|||||||||||||---||||||--|-|||||--|-||-----|||||-||--||||||||||||||  3 [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase
||||--||||-||----|||||----||||||||||||||||-||-|---|--------|||----  3 [P] COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
|||||||||||||||-|||||-----|||||-----------|||-|--|--||||---|||||--  3 [C] COG0644 Dehydrogenases (flavoproteins)
|||-----||-|-||-|---||-----||||--|||||----||-||-||--|--|---|||-|-|  3 [R] COG0655 Multimeric flavodoxin WrbA
|||||||||||||---||||-|---|||||||||||-||-|||||||-||--|--|---|||||--  3 [P] COG0704 Phosphate uptake regulator
|||||--||||||---||||||----||||||||||||----|||||-||||||||||||||||--  3 [C] COG0778 Nitroreductase
|||-|||||||||----|||||-----||-||-----|----|||-|-||------------|---  3 [C] COG1032 Fe-S oxidoreductase
|||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||  3 [G] COG1109 Phosphomannomutase
||||--|||||||----|||||--|-||||||||||||||||-||-|-|-|----|---|||----  3 [P] COG1122 ABC-type cobalt transport system, ATPase component
|-||||||||||||||-|||-|---||||||||||||||||-|||||-||-|||||||-|||||--  3 [V] COG1131 ABC-type multidrug transport system, ATPase component
|||||||||||||||||-||-|----|||||-----||-------||--|--||||--||||||--  3 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)
|-|--||||---|-----||-|----|||||-----------|---|--||-|--|---||-||--  3 [R] COG1216 Predicted glycosyltransferases
|-||--||--|-|---|||||||||||||-||||||||-----||||-||-----|------||--  3 [R] COG1266 Predicted metal-dependent membrane protease
||-------|-------|--|---------||||||||-|--------------------------  3 [R] COG1323 Predicted nucleotidyltransferase
|||-|||||||------|------------|-----------------|-----------------  3 [S] COG1433 Uncharacterized conserved protein
|-|-----|--|-------|||---------------|----|--|--|---|--|----------  3 [H] COG1541 Coenzyme F390 synthetase
|||---|||||||---||------------|---|-----------|---|--------||----|  3 [R] COG1708 Predicted nucleotidyltransferases
||-----||--------||||---|--||-|-----------|||-|--|--||||-------|--  3 [C] COG1773 Rubredoxin
|-|--||||--||-----||||----|||||||||-||----|---|--|-|||||--||||||--  3 [M] COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes
||------||------|----|-----||------------------------||-----------  3 [R] COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid
||||--||||---|||--------------------------------------------------  3 [B] COG2036 Histones H3 and H4
|-||----|-----|-||||-|-----||||---|-||----|||---||-----|---|||||--  3 [T] COG2203 FOG: GAF domain
|-||||-||-|||||-|||||||||-|||||||||||||---|||||-||||-|||||||||||--  3 [P] COG2217 Cation transport ATPase
|||-----||--------------------------------------------------------  3 [C] COG2218 Formylmethanofuran dehydrogenase subunit C
|||----||-|-----|-----------------|-||----------------------------  3 [S] COG2445 Uncharacterized conserved protein
|||-----||--------------------------------------------------------  3 [D] COG3640 CO dehydrogenase maturation factor
|-|-----|---------------------------------------------------------  3 [K] COG4742 Predicted transcriptional regulator
|||-||--||-|-||-||||-|----|||-||--|||||---|||||--|--||||---|||||--  2 [P] COG0004 Ammonia permease
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
||||----||||-||-||||-|----||||||--||||----|||||||||||||---||||||--  2 [E] COG0040 ATP phosphoribosyltransferase
||||---||||||||-||||||---||||-||||||||----|||||-||-|---|--||||||||  2 [P] COG0053 Predicted Co/Zn/Cd cation transporters
||||--||||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  2 [E] COG0065 3-isopropylmalate dehydratase large subunit
|||---||||||-||-||||-|----||||||-|||||----||||||||||||||--||||||--  2 [E] COG0066 3-isopropylmalate dehydratase small subunit
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  2 [E] COG0070 Glutamate synthase domain 3
|||||||||||||||-||||-|-----||||---|-||----||||||||--|--|---|||||||  2 [O] COG0071 Molecular chaperone (small heat shock protein)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit
||--|-||--||-|----||-------||-------------|||||-||||-|||---||||---  2 [R] COG0121 Predicted glutamine amidotransferase
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  2 [F] COG0125 Thymidylate kinase
|||-|||||||--||||-||----||--------------------------------------||  2 [I] COG0170 Dolichol kinase
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  2 [K] COG0195 Transcription elongation factor
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  2 [P] COG0226 ABC-type phosphate transport system, periplasmic component
||-||||||||||---|-||-|----|||-------||----|||||-||||---|||||||||--  2 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
||||||--|||||---|-||||----||||-|----||----|||||-||||-||||||||||---  2 [C] COG0247 Fe-S oxidoreductase
|||||||||||||---|-||-|----|||||---||||----|||||-||||---|||||||||--  2 [H] COG0303 Molybdopterin biosynthesis enzyme
|||-|||||||||---||||-|-----||-|------|----||||||||||||||---|||||--  2 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs
|||||||||||||||-||||||--||||||||||---|-|--||||||||||||||||||||||||  2 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs
|||||||||||||-||||||||||-||---||||||||----||||||||||||||||||||||||  2 [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase
|||---|||||-----||||-|--------||--||------|||||-||--|--||||----|--  2 [P] COG0370 Fe2+ transport system protein B
|-||||--|-|||||-||||-|----||||-|--||||----|||||-||-|||||||||||||||  2 [C] COG0372 Citrate synthase
|||-----||----|-|-||||----|||-----|--||---|||||--||----||||||||---  2 [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase
|||||||||--|-----|||-------|||-|---|-|----|||-|-|--|-----------|--  2 [S] COG0393 Uncharacterized conserved protein
||-----|-||-----||||----|-|||-|--|--|-----|||||-||-|-||||||-||||--  2 [M] COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis
|||||||||||||||-||||-|----|---|--|---|----|||||--||||--|||||||||--  2 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases
||||||||||||||||---|----------------------|||||-||----------------  2 [L] COG0417 DNA polymerase elongation subunit (family B)
||||---|||||----||||||----|||||-----||----|||||-||--||||--|||-||--  2 [H] COG0422 Thiamine biosynthesis protein ThiC
||||||||||||||||||||||----|||||||||||||---|||||-||||||||--||||||--  2 [R] COG0456 Acetyltransferases
||||||||||||||||||||||||||||||||||||||--||||||||||||||||||||||||||  2 [O] COG0459 Chaperonin GroEL (HSP60 family)
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  2 [E] COG0460 Homoserine dehydrogenase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  2 [L] COG0468 RecA/RadA recombinase
|||||||||||||||||||||||||-||||-|||||||||||||||||||||||||||||||||||  2 [L] COG0470 ATPase involved in DNA replication
||----||-|||-||-||||||||||||||||||||||----|||||||||||||||||||||-||  2 [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
|||---||||||-||-||||-|----||||||--||||----||||||||||||||--||||||||  2 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase
|-||||--|-|||||||||||||||-||||||||||||----||||||||||||||||||||||||  2 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
|||||||||||||||||-||||----|||||-||-|||----||||||||||||||||||||||--  2 [O] COG0501 Zn-dependent protease with chaperone function
||-|||||-|--|||-||||||-|-|||||||||||||----||||||||||||||||||||||--  2 [F] COG0516 IMP dehydrogenase/GMP reductase
||||||||||||-||-|||-----||-----------|----|||||-|--|--------|-----  2 [P] COG0530 Ca2+/Na+ antiporter
|||||||||-|||||||-||||||-|||||||||||||||||||||||||||||||||||||||||  2 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
||||--||-|-------|||||----||||||||||||||||--------------||||||||||  2 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily
||||||||||||----|-|||---------||||||||----|||||-||||||||||||||||||  2 [O] COG0602 Organic radical activating enzymes
|--------|------||||||---||||-|-----------|||||-||||||||||||||||-|  2 [O] COG0606 Predicted ATPase with chaperone activity
||||||||||||----|||||||||||---||||||||----|||||-||||||||||||||||||  2 [L] COG0608 Single-stranded DNA-specific exonuclease
||||----|--||---||||-|--------|------|----|||||-||||-|||----------  2 [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family)
||||--|||||||||--|--|---|----|||||||||-||||||||-||----------------  2 [R] COG0622 Predicted phosphoesterase
||||||||||||||||-----------|||------------------------------------  2 [O] COG0638 20S proteasome, alpha and beta subunits
|||-----|--|-----|||----------|-----------|||||---||--------|-----  2 [R] COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)
|||--|||-|-|-----|---------||-------------|||-|-------------------  2 [C] COG0650 Formate hydrogenlyase subunit 4
|||---||||------|||||------||-------||----|||||-||--||||||-|||||--  2 [G] COG0662 Mannose-6-phosphate isomerase
|||---||||-|----|-||----------|-----------|||-|---------|||-------  2 [C] COG0680 Ni,Fe-hydrogenase maturation factor
||||||||||||||||||||||||||||||||||||||-|--||||||||||||||||||||||||  2 [U] COG0681 Signal peptidase I
|||-----||---||---|||---|-----||||-||-----|||||||||||--||||-------  2 [C] COG0716 Flavodoxins
|||||||||||||---|-||--||--|||||------|----||||||-|||||||||||||||||  2 [F] COG0717 Deoxycytidine deaminase
|||---|||||||---|---|-||------|---|||-----|||||-||||||||||||||||||  2 [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation
|-|------|------|-||||||------------------|||||-||||||||||||||||||  2 [U] COG0811 Biopolymer transport proteins
|||------|-|----|--|||--------||||||||----|||||-||||-|||||||||----  2 [O] COG0826 Collagenase and related proteases
|-||||||||||||||-|||-|----||||||||||||----|||||-||-||--|||-|||||--  2 [V] COG0842 ABC-type multidrug transport system, permease component
||||--|||||||-----------------|----|||----|||-|---------||---|-|--  2 [K] COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain
|||-----||--------------------------------------------------------  2 [C] COG1029 Formylmethanofuran dehydrogenase subunit B
|||-----||--------------------------------------------------------  2 [C] COG1036 Archaeal flavoproteins
||||||--|||-|---||||||||---||||------|----|||||-|-------|||-------  2 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes
||||||||||-------|------|-----|-----||----|||||-||||--------------  2 [O] COG1067 Predicted ATP-dependent protease
|||---||||-|-----|||------|||||-|-||||----|||||--|-----|---|||||--  2 [G] COG1082 Sugar phosphate isomerases/epimerases
|||||-||||-|-||||||-|------||||---|---|||||||-|--|--|---|--------|  2 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits
|||-|----|-|------|||-----||||----|-------|||||-|------|||-||-|---  2 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase
||||----|||||---|||||||||||||-||||||||||||||||||||||||||||||||||||  2 [V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component
|||---||||-------|------------------------------------------------  2 [C] COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain
|||-----||--------------------------------------------------------  2 [C] COG1153 Formylmethanofuran dehydrogenase subunit D
|||||||||||||------|------|||-------------|||----|-----|---|||||--  2 [R] COG1201 Lhr-like helicases
|-|-||||||||-||||-||------|---|||-||||----|||||--|-----|---|||||-|  2 [M] COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
||||||--||--------||-|----|||--------------------|-----|----------  2 [H] COG1239 Mg-chelatase subunit ChlI
||||||---|--------||------|||--------------------|-----|----------  2 [H] COG1240 Mg-chelatase subunit ChlD
|-||---||--|----||||||----|||||||||||||---|||||-||||||||--||||||--  2 [K] COG1309 Transcriptional regulator
|||||||||||||----|---||||-||||||||||||----|||-|-----|---------|---  2 [K] COG1321 Mn-dependent transcriptional regulator
|-||||--|-|||---|--|-|||---||-|-----|------------------------||---  2 [O] COG1331 Highly conserved protein containing a thioredoxin domain
|||------|--------|||---------|-----------------------------|-|---  2 [P] COG1348 Nitrogenase subunit NifH (ATPase)
|||-||||||---||-||--||-----||-||--||||----|||||-|-----------|-----  2 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family
|-|-------|-----||-|||--|-|||-||||||||----|||||-||||||||---|||||||  2 [K] COG1396 Predicted transcriptional regulators
|-|---|||||-|||-|-||--||--||||||--|||-----|||||-||||---|---|||||--  2 [R] COG1409 Predicted phosphohydrolases
|---|||||||||-----------------------------------------------|-|---  2 [S] COG1415 Uncharacterized conserved protein
||||--||||------|-||-|--|-|---------------------||----|-||||||||--  2 [S] COG1432 Uncharacterized conserved protein
|||---|||-|||---||-||-----------|----|----------------------------  2 [L] COG1468 RecB family exonuclease
|-|||||||-||||||--------------------------------------------------  2 [LO] COG1474 Cdc6-related protein, AAA superfamily ATPase
||||||--||-|------||||-----||-|----|-|--------|-||-----|---|||||--  2 [H] COG1492 Cobyric acid synthase
|||||||||||||-----------------------------------------------------  2 [R] COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain
||||||||||-|||||--------------------------------------------------  2 [L] COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins
|-|||||||||||-----------------------------------------------------  2 [S] COG1602 Uncharacterized conserved protein
||||--|||-|||----|---|--------||-|||||--------------|----------|--  2 [CP] COG1668 ABC-type Na+ efflux pump, permease component
|-|||||||-|||----|-|||----||||||||||||----|||||-|------|------||--  2 [K] COG1695 Predicted transcriptional regulators
|||------|------|-|-----------------------------------------------  2 [R] COG1719 Predicted hydrocarbon binding protein (contains V4R domain)
|||-----||--------------------------------------------------------  2 [S] COG1810 Uncharacterized protein conserved in archaea
||----||----------------------------------------------------------  2 [S] COG1822 Predicted archaeal membrane protein
|--------|-------|--|---------|-||-|||----------------------------  2 [R] COG1827 Predicted small molecule binding protein (contains 3H domain)
|||---|||||-----||------------|------|----|||||-||--||||-----||---  2 [C] COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain
|||||||||||||----|-|||----||||||||||||----|||||-||--||||---|||||--  2 [K] COG1846 Transcriptional regulators
|-|-|-|||-|||-|-||||||----||||||-|||||----|||||--|-|-|||---|||||||  2 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family
||||||-||-||-----|||------|||-----|--|-----------|||---|---||-|---  2 [R] COG1878 Predicted metal-dependent hydrolase
|-----|------------------------|--|||------------|--|-------------  2 [M] COG1887 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC
|||-----||--------||----------------------------------------------  2 [S] COG1900 Uncharacterized conserved protein
|||-----||--------------------------------------------------------  2 [C] COG1908 Coenzyme F420-reducing hydrogenase, delta subunit
|||----|||-------||--|--------||--||------|||||-||--|--|-||----|--  2 [P] COG1918 Fe2+ transport system protein A
|||---||||--------||----------------------------------------------  2 [C] COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit
|||---|||||-----||------------|------|----|||||-||--||||-----||---  2 [C] COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain
|-||||||||||||||--------------------------------------------------  2 [K] COG1958 Small nuclear ribonucleoprotein (snRNP) homolog
|--------|||----||||||---||||||||||-||----||||||||--||||--||||||--  2 [V] COG1968 Uncharacterized bacitracin resistance protein
|||---||||--|-----------------|---||||----|||||--|-|--------------  2 [R] COG1988 Predicted membrane-bound metal-dependent hydrolases
||||||-||||||---||||-|-----||-|----|||----------|----|||||--|-||--  2 [R] COG1994 Zn-dependent proteases
||--||||-||||------------------------------------------------|----  2 [F] COG2019 Archaeal adenylate kinase
|||-----||--------------------------------------------------------  2 [C] COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase
|||||||||||||-------------||--|--------------|---|-|---|---||-||--  2 [NU] COG2064 Flp pilus assembly protein TadC
||--||||-|-----------|--------------------------------------------  2 [G] COG2074 2-phosphoglycerate kinase
||||--||---------|||-|----|-------||||----------||---------|||--||  2 [P] COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit
|-|-|||||------------|--------------------------------------------  2 [C] COG2191 Formylmethanofuran dehydrogenase subunit E
||-------|---||-|----|-----||------------------------||-----------  2 [R] COG2229 Predicted GTPase
|-||--|||||||-----------------------------------------------------  2 [S] COG2433 Uncharacterized conserved protein
|||---||-|-|------------------|-----------------------------------  2 [S] COG2454 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  2 [R] COG2520 Predicted methyltransferase
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  2 [H] COG2896 Molybdenum cofactor biosynthesis enzyme
|-||-----|--|---|--------------------------------|-----|----|-|---  2 [S] COG3174 Predicted membrane protein
|||---||||--------||----------------------------------------------  2 [C] COG3259 Coenzyme F420-reducing hydrogenase, alpha subunit
|||--|||-|-|---------------||-------------|||-|-------------------  2 [C] COG3260 Ni,Fe-hydrogenase III small subunit
|||--|||-|-|---------------|--------------|||-|-------------------  2 [C] COG3261 Ni,Fe-hydrogenase III large subunit
|-|---------------||----------|-----||-----------------|---|||||--  2 [S] COG3339 Uncharacterized conserved protein
|-|------------------------||------------------------------||-|---  2 [S] COG3482 Uncharacterized conserved protein
|--|-----|--------------------------------------||---------||||---  2 [R] COG3608 Predicted deacylase
|||-|||||||||---||---|--------------------------------------------  2 [G] COG3635 Predicted phosphoglycerate mutase, AP superfamily
|--------|----------------|---||||||||----------------------------  2 [M] COG3764 Sortase (surface protein transpeptidase)
|||||||||||||---||||||--|-||||||||||||-||||||||-||-||--|--|||||---  2 [G] COG3839 ABC-type sugar transport systems, ATPase components
||-------|--------------------------------------------------------  2 [R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase
|||------|--------------------------------------------------------  2 [H] COG4054 Methyl coenzyme M reductase, beta subunit
|||------|--------------------------------------------------------  2 [H] COG4055 Methyl coenzyme M reductase, subunit D
|||------|--------------------------------------------------------  2 [H] COG4057 Methyl coenzyme M reductase, gamma subunit
|||------|--------------------------------------------------------  2 [H] COG4058 Methyl coenzyme M reductase, alpha subunit
|||------|--------------------------------------------------------  2 [H] COG4063 Tetrahydromethanopterin S-methyltransferase, subunit A
||-------|--------------------------------------------------------  2 [S] COG4066 Uncharacterized protein conserved in archaea
|-|-----|---------------------------------------------------------  2 [R] COG4747 ACT domain-containing protein
|-|-------|--------|------|---|-----||----------------------------  2 [KT] COG4978 Transcriptional regulator, effector-binding domain/component
||||||--|||||-|-|-||||||--|||||---||||----|||||-||-|||||||||||||--  1 [H] COG0001 Glutamate-1-semialdehyde aminotransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase
||-|||-|-||-|||-|-|||------|||-----|-|----------------------------  1 [P] COG0003 Oxyanion-translocating ATPase
|||||||||||||||-||||-------||||-||-|||----|--||--|--|------||-|---  1 [F] COG0005 Purine nucleoside phosphorylase
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [E] COG0006 Xaa-Pro aminopeptidase
||||||--|||||||-|-||||----|||||---||||----||||||||--||||---|||||--  1 [H] COG0007 Uroporphyrinogen-III methylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||---|||||||  1 [J] COG0009 Putative translation factor (SUA5)
|||||||||||||||---||||--------|-|-|-||----|||-|-||-|||||||-||||---  1 [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family
||-||||||||--|--|||-------|||-|--||-||----------------------------  1 [S] COG0011 Uncharacterized conserved protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0012 Predicted GTPase, probable translation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0013 Alanyl-tRNA synthetase
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0015 Adenylosuccinate lyase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit
||||||||||||||||--||||--||----|||||||||||||||||||-|||-------------  1 [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0018 Arginyl-tRNA synthetase
|||-||--||---||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0019 Diaminopimelate decarboxylase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [I] COG0020 Undecaprenyl pyrophosphate synthase
|||||||||||||||---||----------------------|||||-||||--------------  1 [J] COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins
||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||||||||||  1 [J] COG0024 Methionine aminopeptidase
||||||-|||---|||--||-|----|||--|-||||-----|||||-||-||------|--|---  1 [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0030 Dimethyladenosine transferase (rRNA methylation)
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase
|--|---|--|||||-||||||--|-|||-|||||||||||||||||-||||-|||--||||||--  1 [F] COG0035 Uracil phosphoribosyltransferase
||||||--|||||||-||||||||-|||||||||||||-||||||||-|-|||--|--||||||||  1 [C] COG0039 Malate/lactate dehydrogenases
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
||||----||---|||||||||||||||||||||||||----|||||-||||||||||||||||||  1 [J] COG0042 tRNA-dihydrouridine synthase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases
|||||||||||||||-||||||----||||||||||||----|||-|--|--|--|||||||||--  1 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--||||||||  1 [C] COG0045 Succinyl-CoA synthetase, beta subunit
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0048 Ribosomal protein S12
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0049 Ribosomal protein S7
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0051 Ribosomal protein S10
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0052 Ribosomal protein S2
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0054 Riboflavin synthase beta-chain
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||--  1 [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
|||----|||||-|--||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EH] COG0059 Ketol-acid reductoisomerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0060 Isoleucyl-tRNA synthetase
|||||||||||||||||||||---|||||||||||||||-||||||||||||||||||||||||||  1 [G] COG0061 Predicted sugar kinase
|||||||||||||||-||||-|----|||||-----------|||||-||--|--|||||||||--  1 [S] COG0062 Uncharacterized conserved protein
||||||||||||||||||||-|----||||||--|||-----|||||-||--||||||||||||--  1 [G] COG0063 Predicted sugar kinase
||||----||-||||-||||||||||||||||||||||||||-------|---|||||||||||||  1 [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)
|||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||--  1 [E] COG0067 Glutamate synthase domain 1
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0068 Hydrogenase maturation factor
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [R] COG0073 EMAP domain
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--||||||||  1 [C] COG0074 Succinyl-CoA synthetase, alpha subunit
||||||||||||||--||||-|--------||--|-||--------|-||------||-||-||--  1 [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase
||||--||||--||----||-------||--|---|-|----||||--|-|---------|||---  1 [E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins
||||||--||||-||-||||-|----||||||-|||||----|||-||||||||||--||||||--  1 [E] COG0077 Prephenate dehydratase
|||||||||||||||-||||-|---|||||||||||||--|-||||||||||||||--||||||--  1 [E] COG0078 Ornithine carbamoyltransferase
|||||||||||||||-||||||----||||||--||||----||||||||||||||--||||||--  1 [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0080 Ribosomal protein L11
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0081 Ribosomal protein L1
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0082 Chorismate synthase
|||---||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0084 Mg-dependent DNase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0087 Ribosomal protein L3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0088 Ribosomal protein L4
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0089 Ribosomal protein L23
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0090 Ribosomal protein L2
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0091 Ribosomal protein L22
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0092 Ribosomal protein S3
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0093 Ribosomal protein L14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0094 Ribosomal protein L5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0096 Ribosomal protein S8
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0097 Ribosomal protein L6P/L9E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0098 Ribosomal protein S5
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0099 Ribosomal protein S13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0100 Ribosomal protein S11
|||||||||||--||||||||||||||||||||||||||-||||||||||||||||||||||||||  1 [J] COG0101 Pseudouridylate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0102 Ribosomal protein L13
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0103 Ribosomal protein S9
||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0104 Adenylosuccinate synthase
|||||||||||||||||-||-||||||||||--|||||----|||||-||||||||||||||||||  1 [F] COG0105 Nucleoside diphosphate kinase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0107 Imidazoleglycerol-phosphate synthase
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase
||||---|-||--||--|||-|||--||||||||||||----|||-|-||-|-|||--||||||-|  1 [R] COG0110 Acetyltransferase (isoleucine patch superfamily)
|||||||||||||||-||||-|----||||||--||||----|||||-|||||--|||||||||--  1 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
||||||||||||||||||||-|||||||||||||||||-|||||||||||||||||||||||||||  1 [E] COG0112 Glycine/serine hydroxymethyltransferase
||||||--|||||||-|-||||||--|||||---||||----|||||-||-|||||||||||||||  1 [H] COG0113 Delta-aminolevulinic acid dehydratase
||||----|||--||-||||||----||||||||||||----|||||-||||||||||||||||||  1 [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0118 Glutamine amidotransferase
||||||||||||||||--||-|||||----||||||------||||||||||||||---|||||--  1 [G] COG0120 Ribose 5-phosphate isomerase
|-||--|||---||||--|--|-----||-|-----||-|--|||||-||--|--|---|||||--  1 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase
||||--|||||||||||-||-|------------|-||----------||---|||---|||||--  1 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0124 Histidyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0126 3-phosphoglycerate kinase
||||||||||||||||||||||||||||||||||||||----|||||-||||||||--||||||--  1 [F] COG0127 Xanthosine triphosphate pyrophosphatase
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase
|||----||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase
||||||||||||||||||||||||||||||||||||||||--||||||||||||||--||||||||  1 [J] COG0130 Pseudouridine synthase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0131 Imidazoleglycerol-phosphate dehydratase
||||---|||---||-|||||||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0133 Tryptophan synthase beta chain
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0134 Indole-3-glycerol phosphate synthase
||||||-||||||||-||||-||---|---||-|||||----||||||||||||||||||||||--  1 [E] COG0135 Phosphoribosylanthranilate isomerase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0136 Aspartate-semialdehyde dehydrogenase
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0137 Argininosuccinate synthase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0139 Phosphoribosyl-AMP cyclohydrolase
||||-----|||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase
||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0141 Histidinol dehydrogenase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [H] COG0142 Geranylgeranyl pyrophosphate synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0143 Methionyl-tRNA synthetase
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0148 Enolase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||--  1 [G] COG0149 Triosephosphate isomerase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||--  1 [F] COG0150 Phosphoribosylaminoimidazole (AIR) synthetase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||||||||||--  1 [F] COG0151 Phosphoribosylamine-glycine ligase
||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||||  1 [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
||||----|||||||-||||||||||||||||||||||||||---|---|---|||||||||||||  1 [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases
||||--||||||-|--|||||-----|||||-||-|||----|||||-||||||||||-||-||--  1 [H] COG0157 Nicotinate-nucleotide pyrophosphorylase
||||||-||||||||-||||-||---||||||-|||||----||||||||||||||||||||||--  1 [E] COG0159 Tryptophan synthase alpha chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0162 Tyrosyl-tRNA synthetase
|||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-|||  1 [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase
||||||||||||||||||||||||-|||||||||||||----|||||-||||||||||||||||||  1 [L] COG0164 Ribonuclease HII
||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||--  1 [E] COG0165 Argininosuccinate lyase
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0167 Dihydroorotate dehydrogenase
||||--||||--|||-||||||--||------||||||-||||||||-||||-||---||||----  1 [P] COG0168 Trk-type K+ transport systems, membrane components
||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||--  1 [E] COG0169 Shikimate 5-dehydrogenase
|||||||||||||||-||||||--||||||||||||||||||||||||||--||||||||||||--  1 [H] COG0171 NAD synthase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0172 Seryl-tRNA synthetase
|||||||||||||||-||||-|----||||-|||||||----|||||-||||||||||||||||||  1 [E] COG0174 Glutamine synthetase
||||||||||||||||||||||||||||||||||||||----||||||||||||||||||||||||  1 [L] COG0177 Predicted EndoIII-related endonuclease
|-||------------|||||||||||||||||||||||||||||||-||||||||||||||||||  1 [L] COG0178 Excinuclease ATPase subunit
|||||||||||||||---||-|----||||----||||----|||||-||-|-|||--||||||--  1 [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0180 Tryptophanyl-tRNA synthetase
||||||--|||||||-|-||||||--|||||---||||----||||||||-|||||||||||||||  1 [H] COG0181 Porphobilinogen deaminase
|||-|||||||||||-|||||---------------|------------|--|-------|-|---  1 [J] COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family
||||||||||||||||--|-||---||||||||-||||----|||||-|||----|||-|||||||  1 [I] COG0183 Acetyl-CoA acetyltransferase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0184 Ribosomal protein S15P/S13E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0185 Ribosomal protein S19
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-||||||  1 [J] COG0186 Ribosomal protein S17
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0197 Ribosomal protein L16/L10E
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0198 Ribosomal protein L24
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0199 Ribosomal protein S14
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0200 Ribosomal protein L15
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0201 Preprotein translocase subunit SecY
||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit
||||||||||------||||||--||||||||||||||-|||||||||||||||||||||||||||  1 [D] COG0206 Cell division GTPase
|||-----||---|||----||----||||||||||||-|||||||||||||||||---|||||--  1 [F] COG0207 Thymidylate synthase
|-|||||||-|||||||||-|||||-||||||||||||-|||||||||||||||||||||||||||  1 [F] COG0209 Ribonucleotide reductase, alpha subunit
|--|-----||||||-|-|||||||-||||||-|||||--|||||||-||||||||||||||||||  1 [H] COG0212 5-formyltetrahydrofolate cyclo-ligase
|||||||||||||||--|--||----|||||--|||||------------||--------------  1 [H] COG0214 Pyridoxine biosynthesis enzyme
|-||||||-|-||||||-||||||--|||||----|-|||||||||||||||||||||||||||||  1 [C] COG0221 Inorganic pyrophosphatase
|-||-------|-||---||||--|-|||||||||||||||||||||-||||||||||||||||--  1 [O] COG0225 Peptide methionine sulfoxide reductase
|-||---------||---||||--|-|||-||||||||-||||||||-||||||||||||||||--  1 [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)
||||-||||||-|||-||-||------||||-||-|||-||-|||||-|||||--|||--||||||  1 [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases
||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||||  1 [H] COG0237 Dephospho-CoA kinase
|-------|----|||||||||||||||||||||||||||--|||||-||||||||||||||||||  1 [C] COG0240 Glycerol-3-phosphate dehydrogenase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0244 Ribosomal protein L10
|||||||||||||-|-||||||||||||||||||||||||||||||||||||||||||||||||||  1 [K] COG0250 Transcription antiterminator
|||||||||||||||-----||----||||||||||||----|||||-|||-||||||||-|----  1 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D
||------||------|||||-||--|||||---||||----||||||||||||||||||||||||  1 [E] COG0253 Diaminopimelate epimerase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0255 Ribosomal protein L29
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0256 Ribosomal protein L18
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI)
|-||------||-||-||||||||||||||||||||||----||||||||||||||||||||||||  1 [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
|||---|||||||-----------------|-|||-|--||-|||-|-|-||--------------  1 [G] COG0269 3-hexulose-6-phosphate synthase and related proteins
||----||-||||-|---||------|---|-||--||||--|||-|-|-|-||||||--|-||--  1 [L] COG0270 Site-specific DNA methylase
|--|||----|-|---||||-|--|-|||||||||||||||||||||-|-||-------||-|---  1 [F] COG0274 Deoxyribose-phosphate aldolase
|||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [F] COG0284 Orotidine-5'-phosphate decarboxylase
||||---||----------|-------||--|||||--|||-|||-|-|||||||||||-||-|-|  1 [V] COG0286 Type I restriction-modification system methyltransferase subunit
||||||--|||||||-||||-|----||||||-|||||----|||||-||||||||||||||||--  1 [E] COG0287 Prephenate dehydrogenase
|--|------||-||---||-|----|||||-||--||----|||||-||||||||||||||||--  1 [P] COG0288 Carbonic anhydrase
|||-----||------||||--||--|||-||-|||||----||||||||||||||||||||||||  1 [E] COG0289 Dihydrodipicolinate reductase
||||||--||---|||--------||----------------||||||||||||||---|||||||  1 [J] COG0293 23S rRNA methylase
|||||||||||||||-||||||||--||||||||||||----|||||-||||||||||||||||-|  1 [H] COG0294 Dihydropteroate synthase and related enzymes
|||---||||--------||----------|-----------|||-|---|-----|||-------  1 [O] COG0298 Hydrogenase maturation factor
|||||||||||||----|------|-----|||||||||||||||||-||||--------------  1 [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase
||||||||||||-|---|-|-|||--|||||---||||----||||||||||-||||||||-|---  1 [P] COG0306 Phosphate/sulphate permeases
|||||||||||||---|-||----------|-----------|||-|---------|||-------  1 [O] COG0309 Hydrogenase maturation factor
|||||||||||||||--|---|----|||||--|||||------------||--------------  1 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis
|||||||||-|||---|-||-|----|||-----||||----|||||-||||---|||||||||--  1 [H] COG0314 Molybdopterin converting factor, large subunit
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [H] COG0315 Molybdenum cofactor biosynthesis enzyme
|-||||--|-|||||---||-|||--||||-||-||||----|||||-||||||||--||||||||  1 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II
|-||------------|||||||||||||||||||||||||||||||-||||||||||||||||||  1 [L] COG0322 Nuclease subunit of the excinuclease complex
||||--||||---|||---|||||||||-|||||||||||--||||||||||-||||||-------  1 [S] COG0327 Uncharacterized conserved protein
|||||||||||||---|||||-||--||||||||||||----||||||||||||||||||||||||  1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase
||||--|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||||  1 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0341 Preprotein translocase subunit SecF
||||--||-|------|||||||||||||||---||||-|--|||||-||||||||||||||||||  1 [U] COG0342 Preprotein translocase subunit SecD
|-|-||----|||||-||||-|--|-||||||||||||----|||||-||||||||||||||||--  1 [E] COG0345 Pyrroline-5-carboxylate reductase
|-||--|||--||||---||||----||||||||||||----|||||-||||||||--||||||--  1 [E] COG0346 Lactoylglutathione lyase and related lyases
||||||||||||||--||-||-|||-||||||-|||||-|--|||||-||||||||||||||||-|  1 [L] COG0350 Methylated DNA-protein cysteine methyltransferase
|||||||||||||||-||-|||--|-||||||||||||----|||||-||||||||||||||||--  1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0358 DNA primase (bacterial type)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0361 Translation initiation factor 1 (IF-1)
|||||||||||-||||----------||||||---|||----|||||-||--|-------|-|---  1 [E] COG0367 Asparagine synthase (glutamine-hydrolyzing)
|||||||||||||-----||||----|||-|----|-|----|||-|-||-----|---||||---  1 [H] COG0368 Cobalamin-5-phosphate synthase
|||||||||||||-|--|||----------||||-|||----|||||-------------|-----  1 [C] COG0371 Glycerol dehydrogenase and related enzymes
||||||--|||||---|-||||||--|||||---||||----|||||-||-||||||||-------  1 [H] COG0373 Glutamyl-tRNA reductase
|||---||||------|-||-|--------------------|||-|---------|||-------  1 [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)
||||--||||||----|||||-----|||||----|||----|||||-||--||||||-||-||--  1 [H] COG0379 Quinolinate synthase
|---||----|--|||--|-------||||------------|||-|--------|----|-|---  1 [G] COG0380 Trehalose-6-phosphate synthase
||-|--||---------|||-|--------||-||||-----|||||-||-|-|||--|-----||  1 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase
|-|||||||-|||||-||||-|--|-|||||--|||||----|||||-||--||||||||||||--  1 [R] COG0388 Predicted amidohydrolase
||||----||---|--||||-|----||||||||||||----|||||-|--|--------------  1 [S] COG0391 Uncharacterized conserved protein
|-||----|----||-|-||-|----|||-||||||||----|||-|-||-|||||--||||||--  1 [T] COG0394 Protein-tyrosine-phosphatase
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component
|||---||||------|-||----------|-----------|||-|---------|||-------  1 [O] COG0409 Hydrogenase maturation factor
|-||-------|-|----||------|-----|-||------||||||||----|----|--||--  1 [L] COG0415 Deoxyribodipyrimidine photolyase
||||||||||||||||||||||--||----||--|||-----|||||-||----------------  1 [L] COG0419 ATPase involved in DNA repair
||||||||||||||||||||||--||||||||--||||----|||||-||----------|-----  1 [L] COG0420 DNA repair exonuclease
||||||||||||||||-----|--|||||||---|---||||------------------------  1 [J] COG0423 Glycyl-tRNA synthetase (class II)
||||||--||||----|||||-------------|-|-----||||||||||-|||--||||||--  1 [O] COG0425 Predicted redox protein, regulator of disulfide bond formation
||||--||--||||||||-|-|---||||------|------|||-|--|---|||--|-|-----  1 [P] COG0428 Predicted divalent heavy-metal cations transporter
||||--|||||||||||--|----------------------|||-|--|-----|----------  1 [A] COG0430 RNA 3'-terminal phosphate cyclase
|||---|||||||-|-||||-|-----||-|-----||----|||-|-||---------||-----  1 [S] COG0432 Uncharacterized conserved protein
|||-----|--|-||-|-||-||||--||-||||||||----|||||-||||||||||||||||--  1 [I] COG0439 Biotin carboxylase
|||---||||--|||-||||-|----||||||-|||||----||||||||||-|||--||||||--  1 [E] COG0440 Acetolactate synthase, small (regulatory) subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0441 Threonyl-tRNA synthetase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0442 Prolyl-tRNA synthetase
|-||||-------|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0443 Molecular chaperone
|||||||||||||||-||||||--|||||-||||||-|-||||||||-||-|---|---|||||--  1 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases
||||||||-||||||||||||||||-||||||||||||----||||||||||||||||||||||--  1 [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
|||-|||||-|||||||||||||||--|||-||-||||----||||||||-||--|||||||||||  1 [O] COG0450 Peroxiredoxin
|||||||||||||||-||||||---|||||||||||||----|||||-||||||||||||||||--  1 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase
||-|--||||------||-|----||-||||-----||----------||-----||||-------  1 [D] COG0455 ATPases involved in chromosome partitioning
|||||||||||||||-||||||-|--||||||||||||----||||||||||||||||||||||--  1 [F] COG0461 Orotate phosphoribosyltransferase
|||||||||||||||-||||||--||||||||||||||||||||||||||||||||||||||||-|  1 [FE] COG0462 Phosphoribosylpyrophosphate synthetase
||||||||||||||||--||-|----||||------||-----------|-----|--|||-|---  1 [O] COG0464 ATPases of the AAA+ class
||-|--||-||--||-|-|--|||--|---|||||-||----|||||-||||||||||||||----  1 [P] COG0471 Di- and tricarboxylate transporters
|||-|||||-|||||-|-||-|---|-|||||--||||----|||||-|||-||||||||||||||  1 [P] COG0475 Kef-type K+ transport systems, membrane components
|-|||||||-|||||||-||||----|||||--|||||----|||||-||||||||||||||||--  1 [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||||||||||||  1 [C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0480 Translation elongation factors (GTPases)
||||--||||||||--||||-|---|||||-|||||||----|-||||||||||||--||||||||  1 [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
|-||||-------|||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain
||||||||||||||||||||||----|||||--|||||----|||||-||||||||||||||||||  1 [D] COG0489 ATPases involved in chromosome partitioning
||||||||||||||||||||||----||||||||||||----||||||||||||||||||||||--  1 [R] COG0491 Zn-dependent hydrolases, including glyoxylases
||||||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0492 Thioredoxin reductase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0495 Leucyl-tRNA synthetase
||||----|||-||--||||-||||-----------------|||||-||||||||||||||||--  1 [R] COG0496 Predicted acid phosphatase
|||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0498 Threonine synthase
|||||||||||||||-||||------||||-------------------|--|--|---|||||--  1 [H] COG0499 S-adenosylhomocysteine hydrolase
||||--||-||||||--|||||--|||||-||||||||||||||||||||||-||||||||||---  1 [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
||||||||||||||||||||-|||||||||||||||||||--||||||||||||||||||||||||  1 [F] COG0504 CTP synthase (UTP-ammonia lyase)
||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||--  1 [EF] COG0505 Carbamoylphosphate synthase small subunit
|||---|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||--  1 [I] COG0511 Biotin carboxyl carrier protein
||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||--  1 [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II
|||-||--|--|-||||-||||--|-||||||||||||||||||||||||||||||||-|||||||  1 [LKJ] COG0513 Superfamily II DNA and RNA helicases
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0518 GMP synthase - Glutamine amidotransferase domain
|||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||--  1 [F] COG0519 GMP synthase, PP-ATPase domain/subunit
|-||--||-|-||-|--||||||||||||||||||||||||||||||-|||||--|||||||||--  1 [E] COG0520 Selenocysteine lyase
|||||||||||||---|--|-|----|||||---||||----|||||-||||---|||||||||--  1 [H] COG0521 Molybdopterin biosynthesis enzymes
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0522 Ribosomal protein S4 and related proteins
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0525 Valyl-tRNA synthetase
|||||-|||||||||-||||-|||--||||||-|||||----||||||||||||||||||||||||  1 [E] COG0527 Aspartokinases
|||||||||||||---||||||||||||||||||||||||||||||||||||||||||||||||||  1 [F] COG0528 Uridylate kinase
||||||--||||||||--|||-||--|||||||||||||||||||||-|||||--|---|||||||  1 [E] COG0531 Amino acid transporters
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG0532 Translation initiation factor 2 (IF-2; GTPase)
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0533 Metal-dependent proteases with possible chaperone activity
||||--|||---|||-|||-||--|||||-|||||||||||||||||-||||||||||||||||--  1 [V] COG0534 Na+-driven multidrug efflux pump
|||||||||||||||-||||||----||||||||||||----||||||||--||||||||||||--  1 [F] COG0540 Aspartate carbamoyltransferase, catalytic chain
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0541 Signal recognition particle GTPase
|------------||||||||||||||||||||||||||-|||||||-||||||||||||||||||  1 [O] COG0542 ATPases with chaperone activity, ATP-binding subunit
|||-||||||-|-||-||--|---|-|||-||-|-|||----|||||-||---|||---|----||  1 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||--  1 [E] COG0547 Anthranilate phosphoribosyltransferase
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||-|  1 [E] COG0548 Acetylglutamate kinase
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0550 Topoisomerase IA
|||||||||--------|--|-|||-----|||||||||-|||||||||||||||||||-------  1 [L] COG0551 Zn-finger domain associated with topoisomerase type I
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [U] COG0552 Signal recognition particle GTPase
||||||||||||------||-|-----||-|------|----|||||-||||||||---|||||--  1 [O] COG0555 ABC-type sulfate transport system, permease component
|-||------------|||||||||||||||||||||||||||||||-||||||||||||||||||  1 [L] COG0556 Helicase subunit of the DNA excision repair complex
|-|||||||-|||||||||||-|||||||||||||||||||||||||-||||||||||||||||||  1 [I] COG0558 Phosphatidylglycerophosphate synthase
|||||||||||-|||-----|--|--||||||----------|||||-||||||||||||||||--  1 [E] COG0560 Phosphoserine phosphatase
|-||||||||||||||-||||||||||||||||||||||||||||||||-||-|||---||-|---  1 [R] COG0561 Predicted hydrolases of the HAD superfamily
|--------------------|----|||||---------|||---|-----------||------  1 [M] COG0562 UDP-galactopyranose mutase
||||||--||-||-----||-|--------------------|||||-||||||||---|||||-|  1 [J] COG0565 rRNA methylase
||||--|||||-|---||||||--||-||---||||||-||||||||-||||-||---||||----  1 [P] COG0569 K+ transport systems, NAD-binding component
||||---||||||---||||-|---||||||||||||||-|||||||-|-|||--|--||||||--  1 [P] COG0573 ABC-type phosphate transport system, permease component
|||||||||||||||||||||||||||||||||||||||||||||||-||||||||||||||||||  1 [I] COG0575 CDP-diglyceride synthetase
|-||||-------||-||||||||||||||||||||||||||||||||||||||||||||||||||  1 [O] COG0576 Molecular chaperone GrpE (heat shock protein)
||||----||||-----||||||||-|||-||||||||----|||||-||-|-|||--||||||--  1 [V] COG0577 ABC-type antimicrobial peptide transport system, permease component
|-------|--|-|||-||-||---|----||||||||-|||||||||-||||--|---|||||--  1 [G] COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG0581 ABC-type phosphate transport system, permease component
|||||||||--||---||||||||--||||||||||||||--|||||-||||||||||||||||||  1 [L] COG0582 Integrase
||------||------|-||||----||||||||||||----|||||-||||||||--||||||--  1 [K] COG0583 Transcriptional regulator
|||||||||||||||||----|--------------------|||||-||||----|||-------  1 [S] COG0585 Uncharacterized conserved protein
|-|||||||--||||---|-|--|--|------||-||----|||||-||||-||||||||||-||  1 [ER] COG0591 Na+/proline symporter
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog)
|||||||||||||---|-||----------|---|-||----|||||-||||||||||||||||||  1 [R] COG0603 Predicted PP-loop superfamily ATPase
|-||||----|||||||-||-|||-|||||||||||||----||||||||||||||||||||||||  1 [P] COG0605 Superoxide dismutase
|-||||--|-||-||||-||||---|||||||||||||----|||||||||||||||||||-||||  1 [P] COG0607 Rhodanese-related sulfurtransferase
||||---||----------|-----------||-||--|||-------||||||--|||-||-|-|  1 [V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
|||||||||||||---|-||------||||------||----||||||||||||||--|----|--  1 [H] COG0611 Thiamine monophosphate kinase
|||||||||||||||||--------------|--|||----------------------------|  1 [MI] COG0615 Cytidylyltransferase
|||||||||-|-|---|||||||||-||||-----|||----||||||||||||||||||||||||  1 [OU] COG0616 Periplasmic serine proteases (ClpP class)
|||||||||||||||-||-----|--||||-|-|||||----||||||||||||||--||--||--  1 [E] COG0620 Methionine synthase II (cobalamin-independent)
|||||||||||||---||||||-||-|||||---|-||----||||||||||||||||||||||||  1 [J] COG0621 2-methylthioadenine synthetase
||||--|||-------||||||--|||||-||||||||----||||||||||||||||||||||||  1 [R] COG0628 Predicted permease
||||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K
|-||----|----||-||||||||-|||||||||||||----|||||-||||||||||||||||||  1 [T] COG0642 Signal transduction histidine kinase
||||||||--||||||||----||---||||---|||||||||||||||-----------------  1 [L] COG0648 Endonuclease IV
||||-||||-|||----|||-|----|||-----||||----|||-|-||---------|||--||  1 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit
|-||---------|||--||||--|-||||||||||||----|||||-||||||||||||||||--  1 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
|-||||-----|-||---||-------||||------|----|||||-||-|||||---|||||||  1 [R] COG0661 Predicted unusual protein kinase
|||-||||-|-|----|-||-|----|||-|-----||----|||-|-||--||||--||||||||  1 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily
|||||||||||||-||||||||--|||||-||||||||----||||||||--||||||||||||||  1 [M] COG0668 Small-conductance mechanosensitive channel
||||--||-|-|-||||-||||--|-||||||||||||----|||||-|||||--|||-|||||||  1 [I] COG0671 Membrane-associated phospholipid phosphatase
|-||||||-|||-||-||||-|----|---||||||||----|||||-||-|---|||||||||--  1 [R] COG0673 Predicted dehydrogenases and related proteins
||----||--|------|------------|---|-------|||||-||-||--|---||-|---  1 [M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase
||-------|---||-|||||-----|---||--||||----||||--||-||--|--||||||||  1 [R] COG0679 Predicted permeases
|||-----||---|-------|----||||-------|----|||||-||||---|---||-|---  1 [H] COG0684 Demethylmenaquinone methyltransferase
||||----||---||-----||||---||||-----||----|||||-|||||||||||||||-||  1 [I] COG0688 Phosphatidylserine decarboxylase
|---|||||||||||||--|||----||||-----|||----|||||-||||||||---|||||||  1 [J] COG0689 RNase PH
|-||----|----|||-|||-|----|||||||||||-----|||||-||||||||---|||||||  1 [O] COG0695 Glutaredoxin and related proteins
|-|||||||-|||||||||||||||-|||-||-|||||----||||||||||||||||||||||||  1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
|||-----||------||||-------||-|-||-|||----|||-------------|-------  1 [R] COG0701 Predicted permeases
|-|-||--|--|-|||--||||--|||||-||||-||-----|||||-||||||||||||||||||  1 [L] COG0708 Exonuclease III
||||||-|||||-||-|-----||-------||||||-----|||-|------||-----------  1 [E] COG0710 3-dehydroquinate dehydratase
|||||||||||||---||||-|---||||||---||||----|||||-||--|--|---|||||--  1 [R] COG0714 MoxR-like ATPases
|||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||--  1 [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
||||||||||||----||||----------|---|-||----|||||-||||||||||||||||||  1 [H] COG0720 6-pyruvoyl-tetrahydropterin synthase
||||----||-||---||||||||||||||||||||||--||-------|---|||||||||||||  1 [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit
|||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||--  1 [P] COG0725 ABC-type molybdate transport system, periplasmic component
|||||||||||||---||||||----|--|||--||||----|||||-||||||||||||||||--  1 [R] COG0730 Predicted permeases
|||||||||||||||--||||---------|-------------------------|||-------  1 [C] COG0731 Fe-S oxidoreductases
||||-|-||----------|-------||--|||||--|||||||-|-|||||---|||-||-|-|  1 [V] COG0732 Restriction endonuclease S subunits
|--|----|----||-|||--|--|-|---|||-||||-|--|||||-|-||---|||-||-|---  1 [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases
|||||||||||||---|-||-|----|||-----||||----|||||-||||--||||||||||--  1 [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A
|||||||||||||---||||||||||||||||||||||----|||||-||||||||||||||||||  1 [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1
|--------|------||||||||||||||||||||||----||||||||||||||||||||||||  1 [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase
|||------|------||||||||||||||||||||||----||||||||||||||||||||||||  1 [M] COG0770 UDP-N-acetylmuramyl pentapeptide synthase
|--------|------||||||||||||||||||||||----||||||||||||||||||||||||  1 [M] COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase
|-|---|||-|-|---||||||--|-||||--||--||------------||----||-||||---  1 [O] COG0785 Cytochrome c biogenesis protein
|-|---|-|----|---|||------|||-|----||--------------|--|----|------  1 [P] COG0798 Arsenite efflux pump ACR3 and related permeases
|-||--|||-|-|---|||||||||-||||||||||||-------||--|||-||---|||-|-||  1 [P] COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
|-||||----|||---|-||||--|-|||-|---||||----|||||-||||||||||||||||--  1 [R] COG0824 Predicted thioesterase
||||||--|---------------------------------------------------------  1 [F] COG0856 Orotate phosphoribosyltransferase homologs
|||-----||-----------|---|----|----|||----|||--------------||||---  1 [F] COG1001 Adenine deaminase
||||--||---------|||-|----|-------||||----------||---------|||--||  1 [P] COG1006 Multisubunit Na+/H+ antiporter, MnhC subunit
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG1010 Precorrin-3B methylase
||||--||-|||-|||-|-|-|--|||||-||||||||----|||||-||-|-|||---|||||--  1 [R] COG1011 Predicted hydrolase (HAD superfamily)
||||||---||||||-|-||||----|||||||||||||---|||||-||-|-|||||||||||-|  1 [C] COG1012 NAD-dependent aldehyde dehydrogenases
|||||||||||--||---------------------------------------------------  1 [R] COG1019 Predicted nucleotidyltransferase
|||||||||||||||---------------------------------------------------  1 [L] COG1041 Predicted DNA modification methylase
|||||||||||||-------||--|-----------------|||||-|||||||||||-------  1 [O] COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
|||---|||||||---|-||-|----||||||-|-|||-------|--||-----|---|||||-|  1 [F] COG1051 ADP-ribose pyrophosphatase
||-|||--|||||||-||||||||--||||||--||||----|||||-||||||||||||||||||  1 [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
|||||||||-|||-----|--|-----||--|----------|||||---||---|----------  1 [H] COG1056 Nicotinamide mononucleotide adenylyltransferase
|---||--||------||-||-||||----|----|||----|||||-|||||--||||----|||  1 [D] COG1077 Actin-like ATPase involved in cell morphogenesis
|||||||||||||--|||--|----------||||||||-||------------------------  1 [R] COG1078 HD superfamily phosphohydrolases
||||||||||||||||--------------------------------------------------  1 [R] COG1084 Predicted GTPase
|------------||-|-||||----|---||-|-|||--|||||||-||||-|||||||||||--  1 [M] COG1087 UDP-glucose 4-epimerase
|-|--||||--||-|---||||----|||||||---||----|||||--|||||||---||-||--  1 [M] COG1088 dTDP-D-glucose 4,6-dehydratase
|-|-----|-------|-||-------||-|-----------|||-|-||--|---||-|-|||--  1 [M] COG1089 GDP-D-mannose dehydratase
|-||-||||--||---|-||||----|||||||---||----|---|--|--||||---||-||||  1 [M] COG1091 dTDP-4-dehydrorhamnose reductase
||||||||||||||||--------------------------------------------------  1 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha)
||||||||||||||||--------------------------------------------------  1 [R] COG1094 Predicted RNA-binding protein (contains KH domains)
||||||||||||||||--------------------------------------------------  1 [K] COG1095 DNA-directed RNA polymerase, subunit E'
|-|-|||||||||||---------------------------------------------------  1 [J] COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain)
|-|-||||||||||||--------------------------------------------------  1 [J] COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)
||------||---------|----------------------------------------------  1 [R] COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold
|||||||||||||||||-||-|----------------------------------------|---  1 [R] COG1100 GTPase SAR1 and related small G proteins
|||||||||||||-----------||----------------------------------------  1 [F] COG1102 Cytidylate kinase
|||-----||--------------------------------------------------------  1 [R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes
||||--||||--------------------------------------------------------  1 [L] COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain
|-||--|||-|-|---|||||||||-||-|||||||||----||||||||||-||---|||||-||  1 [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
||||||||||---||---------------------------------------------------  1 [L] COG1111 ERCC4-like helicases
||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||--  1 [P] COG1117 ABC-type phosphate transport system, ATPase component
|-||--|||-|||---|||||||||-|--|||||||||----||||||||||-||---|||||-||  1 [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component
|--|||--|-|||-------||---------|----||----|||------|-||||||-------  1 [C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain
|--|---||-|-|----|||-------||-||||||||----------------------------  1 [C] COG1141 Ferredoxin
|||||||||-|||---||||-|-----||-------------||||||-|--||||||||||||||  1 [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)
|||-||||||||----||--------------------------------------||--------  1 [C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit
|||-----||-|----||------------------------------------------------  1 [C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins
|||-----||-|----|-------------------------------------------------  1 [C] COG1150 Heterodisulfide reductase, subunit C
|||----|||-------|--|---------|-----------|||||-------------------  1 [C] COG1151 6Fe-6S prismane cluster-containing protein
|||-----||--------------------------------------------------------  1 [C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B
||||||||||||||||--------------------------------------------------  1 [R] COG1163 Predicted GTPase
||||----||---||-----|-||-|-||||-----||-----------|--|||||||||||-||  1 [I] COG1183 Phosphatidylserine synthase
||-|-|||-|||----|-||-||||||||||----|||--|||||||-||--||||||||||||||  1 [D] COG1192 ATPases involved in chromosome partitioning
|-||--||--------||||||---|----||||||||------------------|||-------  1 [L] COG1193 Mismatch repair ATPase (MutS family)
|--|------|-|-|------||||-||||||||||||----||||||||||||||||||||||--  1 [L] COG1194 A/G-specific DNA glycosylase
||||||||--|||||||-|||-----|||-||||||||----|||||-||||||||-------|--  1 [KL] COG1199 Rad3-related DNA helicases
||||--||-|--------------------------------------------------------  1 [R] COG1202 Superfamily II helicase, archaea-specific
|||---|||-|||---||--|-----------|----|----|||||----|--------------  1 [R] COG1203 Predicted helicases
|||||||||||||||||-------------------------|----------------||-----  1 [R] COG1204 Superfamily II helicase
|||---||||||-||----|-|----|||-------||-----||---------------|-----  1 [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster
|-|||||||--||----|||-|----|||||||---||----|||||--|--||||---||-||--  1 [M] COG1209 dTDP-glucose pyrophosphorylase
|||----|---|----|--||----|||||||||||||--|||||||-||||||||||||||||--  1 [M] COG1210 UDP-glucose pyrophosphorylase
|-----|||---|---|---|----------------------------|--------|----|--  1 [M] COG1213 Predicted sugar nucleotidyltransferases
||||--||||-|||||--------------------------------------------------  1 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit
|||-----||--------------------------------------------------------  1 [R] COG1223 Predicted ATPase (AAA+ superfamily)
|--||||-|--|-|---|--||-----||-|-|-|-||-------||-||-----|---|||||--  1 [Q] COG1228 Imidazolonepropionase and related amidohydrolases
|||-----||--------------------------------------------------------  1 [C] COG1229 Formylmethanofuran dehydrogenase subunit A
||||-------||-----||-|----|||-----||-|-----------------|------||--  1 [Q] COG1233 Phytoene dehydrogenase and related proteins
||||||||||||||||-|||-|||||||||||||||||----|||-|----|---|------||--  1 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III
||||||||||----|-|-|||-||||----||||||||----||||---|-----|---|||||||  1 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I
|||---||||-------|------------|---------------|-------------------  1 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II
||||||||||||||||--------------------------------------------------  1 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family
||||||||||||-|||-|--|---------|-----------------------------------  1 [KB] COG1243 Histone acetyltransferase
||||||||||--------------------|-----------------------------------  1 [R] COG1244 Predicted Fe-S oxidoreductase
||||||||||||||||--------------------------------------------------  1 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog
||||||--|||||||-||||||||--||||-|||||||-|||||||||||||||||---|||||||  1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
||-|--|||---------------------------------------------------------  1 [S] COG1255 Uncharacterized protein conserved in archaea
||||||||||||||||---------|-----|||||------------|-----------------  1 [I] COG1257 Hydroxymethylglutaryl-CoA reductase
|||||||||||||--|--------------------------------------------------  1 [J] COG1258 Predicted pseudouridylate synthase
|-|---|||-||||--||--------||||------------------------------|-----  1 [I] COG1260 Myo-inositol-1-phosphate synthase
|||---||-||-|---|---|-----------|--|||----|||||-||||-||||||-----||  1 [I] COG1267 Phosphatidylglycerophosphatase A and related proteins
|-||--|||--------||||||-|-|---||||||||---------------------||||-||  1 [R] COG1268 Uncharacterized conserved protein
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I
|||||||||||||-----||||-----||-|----|-|--------|-||-----|---||||---  1 [H] COG1270 Cobalamin biosynthesis protein CobD/CbiB
|-|-||--|||||----||--|----|---------||----|||||-|||||--|--||||||--  1 [E] COG1280 Putative threonine efflux protein
||||||||||||||||-|||||---|----||||||||------------------|||-------  1 [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP
|||---||||--|-----||-------||-|---|-||-----------|------------||--  1 [S] COG1300 Uncharacterized membrane protein
||||||||||-||-----------------------------------------------------  1 [S] COG1303 Uncharacterized protein conserved in archaea
|||||||||||||||---||-|--||||||-||||||-----|||||-||||-||----|||||||  1 [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases
|||||||||||-||||--------------------------------------------------  1 [K] COG1308 Transcription factor homologous to NACalpha-BTF3
|-|||||||||||||||-||-|-----||--------------||||--|-----|----------  1 [R] COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily
||||||||||---|||--------------------------------------------------  1 [L] COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
|||---|||||-|---||------------|-----------------------------------  1 [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins
||||--||---------|---|----|-------||||----------||---------|||--||  1 [P] COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit
|-|-|||||||-|--|||-|-|-|------------------|||||-----|--|--------||  1 [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations
||||--|||||||-----------------------------------------------------  1 [J] COG1325 Predicted exosome subunit
||||--||||--------------------------------------------------------  1 [R] COG1326 Uncharacterized archaeal Zn-finger protein
|||---||-|-------|--|---------||||||------|||||-||||---|----------  1 [F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase
|||--||----------|---------||-------------------------------------  1 [L] COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|-------||-|----||-------------------|----------------------------  1 [L] COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||--||--|||-----|-|-------||-------------------------------------  1 [L] COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|||||||||||||-----------------------------------------------------  1 [KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon
|-|||||||||||-----------------------------------------------------  1 [S] COG1340 Uncharacterized archaeal coiled-coil protein
|||---|||---------------------|-----------------|-----------------  1 [R] COG1342 Predicted DNA-binding proteins
|||--|--||||-----|-||------||---|----|----------------------------  1 [L] COG1343 Uncharacterized protein predicted to be involved in DNA repair
|-|-|||||-|||---||------------------------------------------------  1 [R] COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)
|||--||-||||----||---------||--------|----------------------------  1 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs)
|||-|||||||||||-||--------------------------------------------|---  1 [R] COG1355 Predicted dioxygenase
||-|--||----------------------------------------------------------  1 [S] COG1356 Uncharacterized protein conserved in archaea
||||||||||||||||-|--|---------||||||||----------------------------  1 [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a)
||||--|||||-|----|-|||--------||||||||||--|||-|--|----------|-----  1 [G] COG1363 Cellulase M and related proteins
|||-----||---||-||||-|----||||||--||||-----------|---|||---|||||--  1 [E] COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase)
||----||-|--------------------------------------------------------  1 [R] COG1365 Predicted ATPase (PP-loop superfamily)
||||--||||-||||---------------------------------------------------  1 [J] COG1369 RNase P/RNase MRP subunit POP5
|||||||||||||-----------------------------------------------------  1 [O] COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit
|||||||||||||---||---------||-------------------------------------  1 [S] COG1371 Uncharacterized conserved protein
|||||||||||||--------|--------------|-----------------------------  1 [K] COG1378 Predicted transcriptional regulators
|||---||-|--------------------------||----------------------------  1 [S] COG1379 Uncharacterized conserved protein
|||||||||||||||---------------------------------------------------  1 [O] COG1382 Prefoldin, chaperonin cofactor
||||||||||||||||--------------------------------------------------  1 [J] COG1383 Ribosomal protein S17E
||||||||||--|-----------||-----------------------------------|||||  1 [J] COG1384 Lysyl-tRNA synthetase (class I)
||||--|||||||-----------------------------------------------------  1 [L] COG1389 DNA topoisomerase VI, subunit B
|||||||||||-||||----||||||----------------------------------------  1 [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E
|||---|||--|-----|---|||------|---|||-----------||||---|---||-|---  1 [P] COG1392 Phosphate transport regulator (distant homolog of PhoU)
||||||||||||||||----||||||------||--------------------------------  1 [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D
|||||||||||||-----------------------------------------------------  1 [K] COG1395 Predicted transcriptional regulator
||||||||||||||||--------------------------------------------------  1 [U] COG1400 Signal recognition particle 19 kDa protein
|-|---|---||----|-|--|-----------|--|-----|--|----------|||-------  1 [V] COG1401 GTPase subunit of restriction endonuclease
||-|-----||||----|||-------||------|-|---------------------|||||--  1 [R] COG1402 Uncharacterized protein, putative amidase
||||||||||||||||--------------------------------------------------  1 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
|||||||||||||----------------------------------------------|||||--  1 [R] COG1407 Predicted ICC-like phosphoesterases
|-|-------|-----|--|-|||--||||||---|||----|------------||||-|-|---  1 [R] COG1408 Predicted phosphohydrolases
|||-----||--------------------------------------------------------  1 [R] COG1411 Uncharacterized protein related to proFAR isomerase (HisA)
||||||||||||||||--------------------------------------------------  1 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily
|--|||--|-------|----|---------------------------------|------|---  1 [S] COG1416 Uncharacterized conserved protein
||------||--------------------------------------------------------  1 [S] COG1417 Uncharacterized conserved protein
||||||||||------||--||--||----|||||||||-|||||-|---------|||||-----  1 [R] COG1418 Predicted HD superfamily hydrolase
||---||--|-------|------------------------------------------------  1 [L] COG1421 Uncharacterized protein predicted to be involved in DNA repair
||||||||||--------------------------------------------------------  1 [S] COG1422 Predicted membrane protein
|||---||||--|---|-------------------------------------------------  1 [L] COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III
||-|--||-||------|||----||--------------------------|--|---|||||--  1 [S] COG1430 Uncharacterized conserved protein
||||||||||||||||----||--|--------|--------------------------------  1 [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F
||||--|||||||------------|----|--------------|---------|----------  1 [F] COG1437 Adenylate cyclase, class 2 (thermophilic)
||||||||||||||||--------------------------------------------------  1 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module
||||--|||-------|---||----|---|-------||--|||||-||--||||||||||||-|  1 [R] COG1451 Predicted metal-dependent hydrolase
|-|--------------|||----------|-----------------------------------  1 [R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family
|-|||||||--||||-||--|-----|---||-|||||----|||||-||-|---|---||||---  1 [C] COG1454 Alcohol dehydrogenase, class IV
|||-----||--------------------------------------------------------  1 [C] COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)
|||---||||--|---|-------------------------------------------------  1 [R] COG1458 Predicted DNA-binding protein containing PIN domain
|||||||||||||-----------------------------------------------------  1 [S] COG1460 DNA-directed RNA polymerase, subunit F
||||----||------|-------------------------------------------------  1 [E] COG1465 Predicted alternative 3-dehydroquinate synthase
||||||||||||||||--------------------------------------------------  1 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit
||||||||||--|----|----------------|-||-----------|--||||----------  1 [S] COG1469 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1471 Ribosomal protein S4E
||-|--|||-|||---|--|-|||||||||||||||||----|||||-||--||||||||||||||  1 [K] COG1475 Predicted transcriptional regulators
||||---||----------|-|--------||||||||-----------|-------------|--  1 [K] COG1476 Predicted transcriptional regulators
||||----||------------||---|||--|---------------------------------  1 [S] COG1478 Uncharacterized conserved protein
|---||--|-|||---||||----------|------|----|||||-||||-------|||-|--  1 [R] COG1489 DNA-binding protein, stimulates sugar fermentation
|||||||||||||-----------------------------------------------------  1 [J] COG1491 Predicted RNA-binding protein
||||||--||--------------------------------------------------------  1 [K] COG1497 Predicted transcriptional regulator
||||||||||||||||--------------------------------------------------  1 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog
||||||||||||||||--------------------------------------------------  1 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay
||||||||||||||||--------------------------------------------------  1 [J] COG1500 Predicted exosome subunit
|||||||||||||||||-------------------------------------------------  1 [J] COG1503 Peptide chain release factor 1 (eRF1)
|-|---||||--------------------------------------------------------  1 [S] COG1504 Uncharacterized conserved protein
|--------------------|----||||||||||||----------------------------  1 [S] COG1511 Predicted membrane protein
|||-|||||||||---||-|-|----|---|---|-||----|||||--|-----|---|||||--  1 [J] COG1514 2'-5' RNA ligase
|||-|||-|||||---||-||------||---|--|-|----|||||----|--|---|-------  1 [L] COG1518 Uncharacterized protein predicted to be involved in DNA repair
||||--|||--------|---|---|-|||------|-----|||||-||--|--|-------|||  1 [S] COG1520 FOG: WD40-like repeat
|||||||||||||--------|----|||-|-----||----|||||-||||-|||---|||||--  1 [K] COG1522 Transcriptional regulators
||-|--||-|---||-|--|------|-------|-|--|||-------|||-||---|||||---  1 [L] COG1525 Micrococcal nuclease (thermonuclease) homologs
|||-||--|-||--------------|||-----||||----|||||-||||---|--||||||--  1 [C] COG1526 Uncharacterized protein required for formate dehydrogenase activity
|||||||||||--|||----||----------||--------------------------------  1 [C] COG1527 Archaeal/vacuolar-type H+-ATPase subunit C
|-|-----|------|-|--------|||-|---|--||---|||||-|-||----|||-------  1 [P] COG1528 Ferritin-like protein
||-----||||||-----------------------------------------------------  1 [S] COG1531 Uncharacterized protein conserved in archaea
||------||--------------------------------------------------------  1 [R] COG1532 Predicted RNA-binding protein
||||--||||-||-------|---------||||||||----|||||-||||||||----------  1 [J] COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
||||||||||||||||--------------------------------------------------  1 [R] COG1537 Predicted RNA-binding proteins
|||||||||||||--------------||----------------------------------|--  1 [R] COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon
|||-----||--------------------------------------------------------  1 [KG] COG1548 Predicted transcriptional regulator/sugar kinase
||||||||||-|------------------------------------------------------  1 [J] COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain
||||||||||||||||--------------------------------------------------  1 [J] COG1552 Ribosomal protein L40E
|||------|-------|------------------------||||||||||--------------  1 [P] COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction
|--|-------|-||---||-|----|||-----|-|---------------||||---|||||--  1 [I] COG1562 Phytoene/squalene synthetase
||----|----------|||--------------------------------------------||  1 [P] COG1563 Predicted subunit of the Multisubunit Na+/H+ antiporter
|||--||----------|---------||-------------------------------------  1 [L] COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|-|---|||----------|----------------------------------------------  1 [S] COG1572 Uncharacterized conserved protein
||||--||||||||||---------|-----|||||------------------------------  1 [I] COG1577 Mevalonate kinase
|||---|||||-----||------------------------------------------------  1 [S] COG1578 Uncharacterized conserved protein
||--|||||||||-----------------------------------------------------  1 [K] COG1581 Archaeal DNA-binding protein
|||--||||-------||------------------------------------------------  1 [L] COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|-|-||-----|-||---------------------------|||||-|--|--------------  1 [S] COG1584 Predicted membrane protein
||-|--||-||||----|||||----|||||-----------|||||-||-||------|||||--  1 [OU] COG1585 Membrane protein implicated in regulation of membrane protease activity
||||||--||||-||-|-||||||--|||||---||||----|||||-||-||||||||||||---  1 [H] COG1587 Uroporphyrinogen-III synthase
||||||||||--|-----------------------------------------------------  1 [J] COG1588 RNase P/RNase MRP subunit p29
||-|--|||||||-----------------------------------------------------  1 [L] COG1591 Holliday junction resolvase - archaeal type
|||||||||-||||||--------------------------------------------------  1 [K] COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS
|-|||---|--------|||-------------|--------||||--------|--|--|-||-|  1 [S] COG1598 Uncharacterized conserved protein
|-|-----|---------||-|--------|-|-||||----|||||-||-----|---|||||--  1 [C] COG1600 Uncharacterized Fe-S protein
||||||||||||||||--------------------------------------------------  1 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain
||||--||||-||||---------------------------------------------------  1 [J] COG1603 RNase P/RNase MRP subunit p30
||||||--|||||||-||--||----||||||||||||----||||||||||||||||||||||--  1 [E] COG1605 Chorismate mutase
|||-----||-------|||----------|-----------------------------------  1 [R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily
|||||||||||||-----------------------------------------------------  1 [R] COG1608 Predicted archaeal kinase
|||-----||--------------------------------------------------------  1 [C] COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit
|||---||||--------------------------------------------------------  1 [S] COG1617 Uncharacterized conserved protein
|||-|||||||||---||------------------------------------------------  1 [F] COG1618 Predicted nucleotide kinase
|||---||-|--------||-|--------|-----------------------------------  1 [C] COG1625 Fe-S oxidoreductase, related to NifB/MoaA family
||----||-|--------------------------------------------------------  1 [S] COG1627 Uncharacterized protein conserved in archaea
|||||||||||||--------|--------------------------------------------  1 [S] COG1628 Uncharacterized conserved protein
||--|||||--||-----------------------------------------------------  1 [S] COG1630 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1631 Ribosomal protein L44E
||||||||||||||||--------------------------------------------------  1 [J] COG1632 Ribosomal protein L15E
|-|---||---|----||------------|-----||---------------------||||---  1 [S] COG1633 Uncharacterized conserved protein
|||||||||||||-----------------------------------------------------  1 [R] COG1634 Uncharacterized Rossmann fold enzyme
||||--|||||||||--|------------------------------------------------  1 [H] COG1635 Flavoprotein involved in thiazole biosynthesis
||-|--||-||||------|------||||------------------------------------  1 [L] COG1637 Predicted nuclease of the RecB family
|||-----||-------|||------|---|-----------------------------------  1 [S] COG1641 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
|||||||||||||---------------------||||----------------------------  1 [R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold
||||||--|||-|||-|---|------||-|---||||----||||||||--|||----|||||--  1 [H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)
|||-|||||-------|---|----|----|||||||||-||------------------------  1 [L] COG1658 Small primase-like proteins (Toprim domain)
|-||||||||--|---------------------|--------||-|-|----------||-|---  1 [R] COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif
|||-----||-|------------------------------------------------------  1 [S] COG1665 Uncharacterized protein conserved in archaea
||------||--------------------------------------------------------  1 [S] COG1667 Uncharacterized protein conserved in archaea
|||---||--||-----||||------------------------|------------|-------  1 [R] COG1672 Predicted ATPase (AAA+ superfamily)
||----|||-||------------------------------------------------------  1 [S] COG1673 Uncharacterized protein conserved in archaea
||||--||||||||||--------------------------------------------------  1 [K] COG1675 Transcription initiation factor IIE, alpha subunit
||||||||||||||||--------------------------------------------------  1 [J] COG1676 tRNA splicing endonuclease
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1679 Uncharacterized conserved protein
|-|-------------||--|---------|----|||--------|-||-----|---||-|---  1 [S] COG1683 Uncharacterized conserved protein
||||||-||||||-----------------------------------------------------  1 [EH] COG1685 Archaeal shikimate kinase
|||---|||-|||---||------------------------------------------------  1 [L] COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily)
|-----|||---------------------------------------------------------  1 [S] COG1689 Uncharacterized protein conserved in archaea
|||||||||||||--|||-|-|----|||-|------|----|||-|--|-----|----------  1 [S] COG1690 Uncharacterized conserved protein
|||-----||-------|||------|---|-----------------------------------  1 [R] COG1691 NCAIR mutase (PurE)-related proteins
|||-----||--------------------------------------------------------  1 [S] COG1693 Uncharacterized protein conserved in archaea
||||--||||||||||--------------------------------------------------  1 [L] COG1697 DNA topoisomerase VI, subunit A
|||-||||||-||-----------------------------------------------------  1 [S] COG1698 Uncharacterized protein conserved in archaea
|-----|---------|-------------------------------------------------  1 [S] COG1700 Uncharacterized conserved protein
||||--|||||||-----------------------------------------------------  1 [S] COG1701 Uncharacterized protein conserved in archaea
||------||--------------------------------------------------------  1 [R] COG1707 ACT domain-containing protein
||----||----------------------------------------------------------  1 [S] COG1710 Uncharacterized protein conserved in archaea
|-|||||||---------------------------------------------------------  1 [S] COG1711 Uncharacterized protein conserved in archaea
|||-----|||------|-------------------------------|-----|----------  1 [R] COG1712 Predicted dinucleotide-utilizing enzyme
|--------|--------||-------||||----|||----------|||--|||||||||||||  1 [S] COG1714 Predicted membrane protein/domain
|-||---------------|-|-----||-------------|---|-------------------  1 [V] COG1715 Restriction endonuclease
||||||||||||||||--------------------------------------------------  1 [J] COG1717 Ribosomal protein L32E
||||||||||||||||-----|-----------------------|---|----------------  1 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control
||||--|||||||----|------------------------|||||-||||-||-------||--  1 [S] COG1720 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG1727 Ribosomal protein L18E
|||||||||||||||-|-------------------------------------------------  1 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding
|||-----|||||-----------------------------------------------------  1 [H] COG1731 Archaeal riboflavin synthase
||||||--|--||-----||||----|||-||--||||----|||||-||-||--|--|||-||--  1 [K] COG1733 Predicted transcriptional regulators
||||||||||||||||--------------------------------------------------  1 [J] COG1736 Diphthamide synthase subunit DPH2
||||----||--------------------------------------------------------  1 [R] COG1745 Predicted metal-binding protein
|||||||||||||-----------------------------------------------------  1 [J] COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme)
|||-----|--------|------------------------------------------------  1 [S] COG1751 Uncharacterized conserved protein
||||||||||||||||||||-|--||||||||||||||----|||||-||||||||||||||||||  1 [K] COG1758 DNA-directed RNA polymerase, subunit K/omega
|||---||||||------------------------------------------------------  1 [R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)
||||||||||||||||--------------------------------------------------  1 [K] COG1761 DNA-directed RNA polymerase, subunit L
|||||-|||||||---|-----------------||||----|||||-|-||---|--|||||---  1 [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein
|||---||||-||-------|-----------|---------|||-|-|||---------------  1 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase
||----||----------------------------------------------------------  1 [S] COG1771 Uncharacterized protein conserved in archaea
|-|||||||---------------------------------------------------------  1 [K] COG1777 Predicted transcriptional regulators
|||-|||||||||||---------------------------------------------------  1 [R] COG1779 C4-type Zn-finger protein
|||||||||||||----|------------|-----------|||||||----||-----------  1 [F] COG1781 Aspartate carbamoyltransferase, regulatory subunit
|||||||||||||-----------------------------------------------------  1 [R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain
||||--||||--------------------------------------------------------  1 [S] COG1784 Predicted membrane protein
|||---|||||-|------------------------------------|---------||-|---  1 [S] COG1786 Uncharacterized conserved protein
||------||--------------------------------------------------------  1 [S] COG1790 Uncharacterized protein conserved in archaea
|||||||||||||||||----------||-------||----------|||--||---|||-||--  1 [L] COG1793 ATP-dependent DNA ligase
|||-----||-----------------------------------|--------------------  1 [S] COG1795 Uncharacterized conserved protein
|-|-||-------||-|----|------------||||----------------------------  1 [L] COG1796 DNA polymerase IV (family X)
||||||--||||------||||-----||-|----|-|--------|--|-----|---||||---  1 [H] COG1797 Cobyrinic acid a,c-diamide synthase
||||||||||||||||--------------------------------------------------  1 [J] COG1798 Diphthamide biosynthesis methyltransferase
||-------|----------------|---------|-----------------------------  1 [S] COG1809 Uncharacterized conserved protein
|||||||||||||---|---------------|---------------------------------  1 [E] COG1812 Archaeal S-adenosylmethionine synthetase
||||||||||||||||--------------------------------------------------  1 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1
||--|||||||||||--|---||---|----|-----------------|------------||--  1 [S] COG1814 Uncharacterized membrane protein
|||---||--|-------------------------------------------------------  1 [S] COG1817 Uncharacterized protein conserved in archaea
||----||||||||----------------------------------------------------  1 [R] COG1818 Predicted RNA-binding protein, contains THUMP domain
|||------|---|----|--|-----||||-----|------||||-||------------|---  1 [GC] COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase
|||-----||--------------------------------------------------------  1 [R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)
|-||--||||--|-----------------------------------------------------  1 [P] COG1824 Permease, similar to cation transporters
||||||||||||----||||-|----||||-|--||||--------------------|-||||--  1 [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component
||||--|||||||-----------------------------------------------------  1 [R] COG1829 Predicted archaeal kinase (sugar kinase superfamily)
||||--||||-||---|--|--||------------------|||||----|-------||-|---  1 [G] COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes
|||||||||||-|-----------------------------------------------------  1 [R] COG1831 Predicted metal-dependent hydrolase (urease superfamily)
||||-|||||||-----|------------------------------------------------  1 [S] COG1833 Uncharacterized conserved protein
|||||||||-|-------||-----------------|----------------------------  1 [S] COG1836 Predicted membrane protein
|---|||||-|||----|---------||--------------------------|----------  1 [S] COG1839 Uncharacterized conserved protein
||||||||||||||||||--||--||||||||||||||----||||||||||||||----||||||  1 [J] COG1841 Ribosomal protein L30/L7E
|||---||-|--------------------------------------------------------  1 [S] COG1844 Uncharacterized protein conserved in archaea
|||||||||||||-----------------------------------------------------  1 [S] COG1849 Uncharacterized protein conserved in archaea
|||----||-----------|---------------------------------------------  1 [S] COG1852 Uncharacterized conserved protein
|||||||||||||-----------------------------------------------------  1 [R] COG1855 ATPase (PilT family)
|||---|||-|||---|---|---------------------------------------------  1 [L] COG1857 Uncharacterized protein predicted to be involved in DNA repair
|||||||-|-|-------------------------------------------------------  1 [S] COG1860 Uncharacterized protein conserved in archaea
||||--||---------|---|----|-------||||----------||---------|||--||  1 [P] COG1863 Multisubunit Na+/H+ antiporter, MnhE subunit
|||||||||||||||||-------------------------------------------------  1 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase
|||----|||--|------|--||----|-------------|||||-|--|-------|--||||  1 [S] COG1872 Uncharacterized conserved protein
|---||----|--|||----------||||------------|||-|--------|------|---  1 [G] COG1877 Trehalose-6-phosphatase
|||-----||--------------------------------------------------------  1 [C] COG1880 CO dehydrogenase/acetyl-CoA synthase epsilon subunit
|-|||||||--|-|--|-----||--|||||---|-|-|---|||-|-|--|||||||-||-|--|  1 [R] COG1881 Phospholipid-binding protein
|-------|-----------|---------||||||------|||||-|-||---|----------  1 [C] COG1882 Pyruvate-formate lyase
||--|||||||||-----------------------------------------------------  1 [S] COG1888 Uncharacterized protein conserved in archaea
||||||||||||||||--------------------------------------------------  1 [J] COG1889 Fibrillarin-like rRNA methylase
||||||||||||||||--------------------------------------------------  1 [J] COG1890 Ribosomal protein S3AE
|||-----||--------------------------------------------------------  1 [S] COG1891 Uncharacterized protein conserved in archaea
|-||--||||||------------------------------------------------------  1 [S] COG1892 Uncharacterized protein conserved in archaea
|-------------|-||||-|-----||-------------||||||-|--||||---|||||||  1 [C] COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit
||||||||||||||||---|-------------------------------------------|--  1 [O] COG1899 Deoxyhypusine synthase
|||-||--||||------|||---------|----|----------|--|-----|---|-|----  1 [H] COG1903 Cobalamin biosynthesis protein CbiD
|-------------|-||||-|-----||-------------||||||-|--||||---|||||||  1 [C] COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit
|||---||||-||-----------------------------------------------------  1 [R] COG1907 Predicted archaeal sugar kinases
|||-|||||||||-----------------------------------------------------  1 [S] COG1909 Uncharacterized protein conserved in archaea
|||---||||||||||--------------------------------------------------  1 [J] COG1911 Ribosomal protein L30E
||------||--------||----------------------------------------------  1 [S] COG1915 Uncharacterized conserved protein
||||--||||--------------||--------------------------|-------------  1 [S] COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein)
||||||||--||----|||||-----||--|||--|||-------||--|-----||||||||---  1 [S] COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain
||||----||-----------------|||------------------------------------  1 [S] COG1920 Uncharacterized conserved protein
||--|----|------|-------------------------|||||--|||----|||||-|---  1 [E] COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]
|||-----||------||--|---------||---|------|||---------------------  1 [I] COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)
|||-----||--------------------------------------------------------  1 [C] COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase
||||----|----------|---------------|----------|-------------------  1 [P] COG1930 ABC-type cobalt transport system, periplasmic component
||||--|||||||-----------------------------------------------------  1 [S] COG1931 Uncharacterized protein conserved in archaea
||||||||||--------------------------------------------------------  1 [L] COG1933 Archaeal DNA polymerase II, large subunit
||||||||||||||||--------------------------------------------------  1 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)
|||||||||||||-----------------------------------------------------  1 [R] COG1938 Archaeal enzymes of ATP-grasp superfamily
|-------|----------|------|----|||||||----||||------|||||||||-||--  1 [R] COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog
||||-----|-----------------||-------------|||||--|||-------||-|---  1 [S] COG1944 Uncharacterized conserved protein
||||||||||------------||------------------------------------------  1 [S] COG1945 Uncharacterized conserved protein
||||--||||||||||--------------------------------------------------  1 [L] COG1948 ERCC4-type nuclease
|||-----||--------------------------------------------------------  1 [H] COG1962 Tetrahydromethanopterin S-methyltransferase, subunit H
|||-|||||||||--------------||-------------------------------------  1 [R] COG1964 Predicted Fe-S oxidoreductases
||||--|||---------------------------------------------------------  1 [S] COG1967 Predicted membrane protein
|-|-----------------|-----|---|-----||----|||||--|--|||---|-------  1 [S] COG1971 Predicted membrane protein
|||-----||-|------------------------------------------------------  1 [O] COG1973 Hydrogenase maturation factor
||||||||||||||||--------------------------------------------------  1 [J] COG1976 Translation initiation factor 6 (eIF-6)
||--|||||||||---|-------------------------------------------------  1 [G] COG1980 Archaeal fructose 1,6-bisphosphatase
||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||--  1 [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis
||--||--|||||------------------------|----|||||-|-----------------  1 [S] COG1986 Uncharacterized conserved protein
||||--||||------||||-|----|||-||||||||----|||||-||||||||--|---||--  1 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
||||||||||||||||----------|---------------------------------------  1 [S] COG1990 Uncharacterized conserved protein
||----||-|--------------------------------------------------------  1 [S] COG1991 Uncharacterized conserved protein
||||--||-||||----|------------------------------------------------  1 [S] COG1992 Uncharacterized conserved protein
|||||||||||||||---------------|-----------------------------------  1 [K] COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger)
||||||||||||||||--------------------------------------------------  1 [J] COG1997 Ribosomal protein L37AE/L43A
|||||||||||||||---------------------------------------------------  1 [J] COG1998 Ribosomal protein S27AE
||-------|-------|------------------------------------------------  1 [R] COG2000 Predicted Fe-S protein
||||||||||||||||--------------------------------------------------  1 [J] COG2004 Ribosomal protein S24E
|-|-----||||------------------------------|||||--|||---|--|||-||--  1 [R] COG2005 N-terminal domain of molybdenum-binding protein
|-|-----|--------|||----------------------------------------------  1 [S] COG2006 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2007 Ribosomal protein S8E
||||||||||||||||--------------------------------------------------  1 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5
|-||||-|||-||----||--|--------|||----------------|------------||--  1 [S] COG2013 Uncharacterized conserved protein
|||---||----------------------------------------------------------  1 [S] COG2014 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2016 Predicted RNA-binding protein (contains PUA domain)
|-||---------||------|----||||----||-------------|||||||------||--  1 [E] COG2021 Homoserine acetyltransferase
||||||||||-|||||--------------------------------------------------  1 [J] COG2023 RNase P subunit RPR2
|||-----||--------------------------------------------------------  1 [J] COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type)
|||---||-|--------------------------------------------------------  1 [S] COG2029 Uncharacterized conserved protein
|||---|||--------|------|-----|-----------------------------------  1 [C] COG2033 Desulfoferrodoxin
|||-||||||-||-----------------------------------------------------  1 [S] COG2034 Predicted membrane protein
|--|-------------|--|---|||-----|||--|----------|-----------------  1 [S] COG2035 Predicted membrane protein
|||||||||||||-----||||----|||||------|----|||-|-||-----|---|||||--  1 [H] COG2038 NaMN:DMB phosphoribosyltransferase
||||||---|-|-|||--------------------------------------------------  1 [S] COG2042 Uncharacterized conserved protein
||------||||----|--------------------------------|----------------  1 [R] COG2044 Predicted peroxiredoxins
||--||---|-------|||-|--------|-----|------------------|----------  1 [HR] COG2045 Phosphosulfolactate phosphohydrolase and related enzymes
||||||||||--------------------------------------------------------  1 [R] COG2047 Uncharacterized protein (ATP-grasp superfamily)
|||-----||-|----|-||--------------------------------------|-------  1 [C] COG2048 Heterodisulfide reductase, subunit B
||||||||||||||||--------------------------------------------------  1 [J] COG2051 Ribosomal protein S27E
||||||||||||||||--------------------------------------------------  1 [J] COG2053 Ribosomal protein S28E/S33
|||-----||--------------------------------------------------------  1 [R] COG2054 Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases
||----||-|----------------|---|-----|-----|||-|--|||-------||||---  1 [C] COG2055 Malate/L-lactate dehydrogenases
||||||||||||||||--------------------------------------------------  1 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2
|||-----||--------------------------------------------------------  1 [E] COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase
|--------||||--------|-----||-------||----|||----------|---||-||--  1 [R] COG2068 Uncharacterized MobA-related protein
|||-----||--------------------------------------------------------  1 [C] COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein)
||-|||--||||------|||---------|----|----------|--|-----|---||||---  1 [H] COG2073 Cobalamin biosynthesis protein CbiG
||||||||||||||||--------------------------------------------------  1 [J] COG2075 Ribosomal protein L24E
|||||||||||||||-||------------|-----------------------------------  1 [S] COG2078 Uncharacterized conserved protein
|---||----||||------------|||-------||----|||-|--|-----|---||-|---  1 [R] COG2079 Uncharacterized protein involved in propionate catabolism
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2082 Precorrin isomerase
||----||||--------------------------------------------------------  1 [S] COG2083 Uncharacterized protein conserved in archaea
|-|-||----|||---|-||-|-----||-||---|||----|||||-||||-|||-|-|||||--  1 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases
||||----||---------|------|----|--------------------|--|---||-|---  1 [R] COG2085 Predicted dinucleotide-binding enzymes
||-|--|||||||-----------------------------------------------------  1 [S] COG2090 Uncharacterized protein conserved in archaea
|||||||||||||||---------------------------------------------------  1 [J] COG2092 Translation elongation factor EF-1beta
|||||||||||||-----------------------------------------------------  1 [K] COG2093 DNA-directed RNA polymerase, subunit E''
||||||||||||||||--------------------------------------------------  1 [J] COG2097 Ribosomal protein L31E
||||||--||--------------------------------------------------------  1 [S] COG2098 Uncharacterized protein conserved in archaea
||----------------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2099 Precorrin-6x reductase
||||||||||||||||--------------------------------------------------  1 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB
||||||||||||||||--------------------------------------------------  1 [R] COG2102 Predicted ATPases of PP-loop superfamily
|-|||||||-------|-||||----|||||-----||----||--|-||--||||--||-|||--  1 [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis
|--|--|||||||||---------------------------------------------------  1 [S] COG2106 Uncharacterized conserved protein
||||--||----------------------------------------------------------  1 [J] COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain
|||||||||||||||---------------------------------------------------  1 [R] COG2118 DNA-binding protein
|||-----||----------------------------------------------------|---  1 [S] COG2122 Uncharacterized conserved protein
|-|-||||||||||||--------------------------------------------------  1 [J] COG2123 RNase PH-related exoribonuclease
||||||||||||||||--------------------------------------------------  1 [J] COG2125 Ribosomal protein S6E (S10)
||||||||||-|||||--------------------------------------------------  1 [J] COG2126 Ribosomal protein L37E
|||---|||||||---|-------------------------------------------|-----  1 [R] COG2129 Predicted phosphoesterases, related to the Icc protein
|||---||||||||||--------------------------------------------------  1 [JA] COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain
||||----||||------||-|----|||-----|-||-----------------|----------  1 [S] COG2138 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [J] COG2139 Ribosomal protein L21E
||||----||-|-------|-|----||||--||||||-|--|||||--|--|--|---|||||--  1 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
|||------|--------|-----------------------------------------------  1 [R] COG2144 Selenophosphate synthetase-related proteins
||||||||||||||||--------------------------------------------------  1 [J] COG2147 Ribosomal protein L19E
|-|||||||---------------------------------------------------------  1 [R] COG2150 Predicted regulator of amino acid metabolism, contains ACT domain
|||-||||-||||----|---|----||||-|||||||----|---------|--|---|||||--  1 [R] COG2151 Predicted metal-sulfur cluster biosynthetic enzyme
|||---||||||||||--------------------------------------------------  1 [J] COG2157 Ribosomal protein L20A (L18A)
|||-----||--------------------|-----------------------------------  1 [R] COG2158 Uncharacterized protein containing a Zn-finger-like domain
||----||-|||||||--------------|------|----------------------------  1 [J] COG2163 Ribosomal protein L14E/L6E/L27E
|-------|--------|------------------------------------------------  1 [S] COG2164 Uncharacterized conserved protein
||||||||||-|||||--------------------------------------------------  1 [J] COG2167 Ribosomal protein L39E
|----------------|------------------------||||||||||--------------  1 [P] COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur
||----||-|||||||--------------------------------------------------  1 [J] COG2174 Ribosomal protein L34E
|-||--||---------|---|----|-------||||----------||---------|||--|-  1 [P] COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit
||||||||||||||||--------------------------------------------------  1 [L] COG2219 Eukaryotic-type DNA primase, large subunit
||||||||||||||---|||||----|||-|-||||||----|||||-||-||--|--|||||--|  1 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold
|||-----|||-------------------|---------------|-------------------  1 [C] COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits
|-----||-|-------|--||--------|-||-||-----|||||--|--|------|||||--  1 [M] COG2222 Predicted phosphosugar isomerases
|||-||-----|----||----------------||--------------------|||-------  1 [L] COG2231 Uncharacterized protein related to Endonuclease III
|||-----||--------------------------------------------------------  1 [R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase
|-||--||||---||-|--|-------||-|-----||----|||-|-||--|----------|--  1 [R] COG2234 Predicted aminopeptidases
||||||||||||||||--------------------------------------------------  1 [J] COG2238 Ribosomal protein S19E (S16A)
|----------------||||-|||||||-|---|-||||-----|--||--|||----|||||||  1 [P] COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain)
||||||--||||------|||-----|||-|----|----------|--|-----|---||||---  1 [H] COG2241 Precorrin-6B methylase 1
||||||--||||------|||-----|||-|----|----------|--|---------||||---  1 [H] COG2242 Precorrin-6B methylase 2
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2243 Precorrin-2 methylase
|||||||||||||||---------------------------------------------------  1 [J] COG2260 Predicted Zn-ribbon RNA-binding protein
|||||||||||||--|--------------------------------------------------  1 [J] COG2263 Predicted RNA methylase
|||||||||||||-----------------------------------------------------  1 [H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase
||-|-----|---------|-|-----|||----|-------||||---|-----|--||||||--  1 [E] COG2303 Choline dehydrogenase and related flavoproteins
|--|--------------||-|--------------------------------------------  1 [S] COG2324 Predicted membrane protein
|----------------|||-|--------|-----------|||-|------------|-|----  1 [S] COG2327 Uncharacterized conserved protein
|-----||-||-|-----|-----------------------------------------------  1 [R] COG2403 Predicted GTPase
|-|-------|||----|------------------------------------------------  1 [R] COG2406 Protein distantly related to bacterial ferritins
|-------|||||-----------------------------------------------------  1 [S] COG2410 Uncharacterized conserved protein
|-||||--|||||||-----------|-------|----------|---|-----|---||||---  1 [E] COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog
||-|------|||-----------------------------------------------------  1 [S] COG2429 Uncharacterized conserved protein
||||||||||--||||--------------------------------------------------  1 [U] COG2443 Preprotein translocase subunit Sss1
||||||||||--------------------------------------------------------  1 [S] COG2450 Uncharacterized conserved protein
||----||----------------------------------------------------------  1 [S] COG2456 Uncharacterized conserved protein
|||---||||-|------------------------------------------------------  1 [S] COG2457 Uncharacterized conserved protein
||----||-|---------|-------------------------|---|---||----|-|----  1 [S] COG2510 Predicted membrane protein
|||||||||||||-----------------------------------------------------  1 [J] COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain)
|-----||||--------------------------------------------------------  1 [R] COG2517 Predicted RNA-binding protein containing a C-terminal EMAP domain
||||--|||||||-|--|------------------------|||||-||--||||||||||||--  1 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase
||-||||||||||||-||--------||||------------------------------------  1 [J] COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases
||||----|-|||-----------------------------------------------------  1 [K] COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains
|-|-----|--------|------------|-----------------------------------  1 [R] COG2768 Uncharacterized Fe-S center protein
|||||||||------------|--------------------------------------------  1 [C] COG2811 Archaeal/vacuolar-type H+-ATPase subunit H
||||||--||||------|||------||-|----|----------|--|-----|---||||---  1 [H] COG2875 Precorrin-4 methylase
||||----|---------------------------------------------------------  1 [S] COG2881 Uncharacterized protein conserved in archaea
|||||||||||||-----------------------------------------------------  1 [J] COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||  1 [J] COG2890 Methylase of polypeptide chain release factors
|||---||||--|-----------------------------------------------------  1 [S] COG2892 Uncharacterized protein conserved in archaea
|--|------|||||-|--|-|----||||-------|----|||||-||-----|---|||||--  1 [P] COG2897 Rhodanese-related sulfurtransferase
|-|--------------|------------------------||||||||||--------------  1 [P] COG2923 Uncharacterized protein involved in the oxidation of intracellular sulfur
|------------||-----|-----|||-|--|||-|----|||||-|-|||-----|-------  1 [S] COG2966 Uncharacterized conserved protein
|---------|-------------------------------------|------|--|-------  1 [H] COG2998 ABC-type tungstate transport system, permease component
|--|--------------|-----------------------------|----------|---|--  1 [R] COG3046 Uncharacterized protein related to deoxyribodipyrimidine photolyase
|||-----||-----------------|||------------|||||-||-|-|||----------  1 [H] COG3161 4-hydroxybenzoate synthetase (chorismate lyase)
||||----||--------------------------------------------------------  1 [H] COG3252 Methenyltetrahydromethanopterin cyclohydrolase
||||||--|||-------------------------------------------------------  1 [R] COG3269 Predicted RNA-binding protein, contains TRAM domain
|-|---------------------------------------|||||-||----------------  1 [S] COG3272 Uncharacterized conserved protein
|-||--||||--|-----------------------------------------------------  1 [S] COG3273 Uncharacterized conserved protein
|||||||||||-||||--------------------------------------------------  1 [J] COG3277 RNA-binding protein involved in rRNA processing
|--|||--||||------------------------------------------------------  1 [S] COG3356 Predicted membrane protein
|-||--------------------------|-----||----------------------------  1 [L] COG3359 Predicted exonuclease
||-|-----|--------------------------------------------------------  1 [F] COG3363 Archaeal IMP cyclohydrolase
|-||----||--------------------------------------------------------  1 [R] COG3364 Zn-ribbon containing protein
|-||----||--------------------------------------------------------  1 [S] COG3365 Uncharacterized protein conserved in archaea
|--|||---|-------|-|----------------------------------------|-----  1 [S] COG3367 Uncharacterized conserved protein
|-|-||------|------------------------------------------|------|---  1 [S] COG3369 Uncharacterized conserved protein
|---||-----|----------------------|||----------------------||-|---  1 [R] COG3383 Uncharacterized anaerobic dehydrogenase
||||||||||||||||---------|-----||||||--------|-----------------|--  1 [I] COG3425 3-hydroxy-3-methylglutaryl CoA synthase
|-|||--------------|||--------||-----|--------|------|||----|||---  1 [R] COG3467 Predicted flavin-nucleotide-binding protein
|-|-----|----------------------------------------|-----|---|||||--  1 [S] COG3503 Predicted membrane protein
|-|-----|---------------------|----------------------------|-||---  1 [S] COG3543 Uncharacterized conserved protein
|--------------------|---------|------------------------------||--  1 [S] COG3548 Predicted integral membrane protein
|-----------|--------------||--------------------------|----|-|---  1 [R] COG3552 Protein containing von Willebrand factor type A (vWA) domain
|||----------------|||-----|||--|----------------|---------||-||--  1 [R] COG3576 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase
|------------||-----|-----|||-|--|||-|----|||||-|-|||-----|-------  1 [S] COG3610 Uncharacterized conserved protein
||||||||||||||||--------------------------------------------------  1 [T] COG3642 Mn2+-dependent serine/threonine protein kinase
||-|--------------------------------------------------------------  1 [S] COG3815 Predicted membrane protein
|-|---------------------------|-----||----------------------------  1 [S] COG3874 Uncharacterized conserved protein
|-------||--------------------------------------------------------  1 [R] COG4001 Predicted metal-binding protein
|||------|--------------------------------------------------------  1 [R] COG4002 Predicted phosphotransacetylase
|||------|--------------------------------------------------------  1 [K] COG4008 Predicted metal-binding transcription factor
||-------|--------------------------------------------------------  1 [S] COG4009 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4010 Uncharacterized protein conserved in archaea
|-|-----||--------------------------------------------------------  1 [S] COG4012 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4013 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4014 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family
||-------|--------------------------------------------------------  1 [S] COG4016 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4017 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4018 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4019 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4020 Uncharacterized protein conserved in archaea
|-|------|---||---------------------------------------------------  1 [S] COG4021 Uncharacterized conserved protein
|||------|--------------------------------------------------------  1 [S] COG4022 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4024 Uncharacterized protein conserved in archaea
|-----||-|--------------------------------------------------------  1 [S] COG4025 Predicted membrane protein
|------|-|--------------------------------------------------------  1 [R] COG4026 Uncharacterized protein containing TOPRIM domain, potential nuclease
|||------|--------------------------------------------------------  1 [S] COG4029 Uncharacterized protein conserved in archaea
|-------||--------------------------------------------------------  1 [S] COG4030 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein
|||------|--------------------------------------------------------  1 [S] COG4033 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4035 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4036 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4037 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4038 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4039 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4040 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4041 Predicted membrane protein
||-------|--------------------------------------------------------  1 [S] COG4042 Predicted membrane protein
|--------||||-----------------------------------------------------  1 [S] COG4046 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4048 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4050 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4051 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [R] COG4052 Uncharacterized protein related to methyl coenzyme M reductase subunit C
||-------|--------------------------------------------------------  1 [S] COG4053 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [H] COG4056 Methyl coenzyme M reductase, subunit C
|||------|--------------------------------------------------------  1 [H] COG4059 Tetrahydromethanopterin S-methyltransferase, subunit E
|||------|--------------------------------------------------------  1 [H] COG4060 Tetrahydromethanopterin S-methyltransferase, subunit D
|||------|--------------------------------------------------------  1 [H] COG4061 Tetrahydromethanopterin S-methyltransferase, subunit C
|||------|--------------------------------------------------------  1 [H] COG4062 Tetrahydromethanopterin S-methyltransferase, subunit B
|||------|--------------------------------------------------------  1 [H] COG4064 Tetrahydromethanopterin S-methyltransferase, subunit G
|||------|--------------------------------------------------------  1 [S] COG4065 Uncharacterized protein conserved in archaea
|-------||--------------------------------------------------------  1 [S] COG4068 Uncharacterized protein containing a Zn-ribbon
|||------|--------------------------------------------------------  1 [S] COG4069 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [O] COG4070 Predicted peptidyl-prolyl cis-trans isomerase (rotamase), cyclophilin family
||-------|--------------------------------------------------------  1 [S] COG4071 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4073 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase
||-------|--------------------------------------------------------  1 [S] COG4075 Uncharacterized conserved protein, homolog of nitrogen regulatory protein PII
||-------|--------------------------------------------------------  1 [R] COG4076 Predicted RNA methylase
||-------|--------------------------------------------------------  1 [S] COG4077 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4078 Predicted membrane protein
|||------|--------------------------------------------------------  1 [S] COG4079 Uncharacterized protein conserved in archaea
|||------|--------------------------------------------------------  1 [S] COG4081 Uncharacterized protein conserved in archaea
||-------|--------------------------------------------------------  1 [S] COG4084 Uncharacterized protein conserved in archaea
||-------|--------------------------||----------------------------  1 [R] COG4085 Predicted RNA-binding protein, contains TRAM domain
|--------|--------------------|--|--||----------------------------  1 [S] COG4086 Predicted secreted protein
|||------|--------------------------------------------------------  1 [R] COG4087 Soluble P-type ATPase
|||------|--------------------------------------------------------  1 [S] COG4090 Uncharacterized protein conserved in archaea
||--------------|-||-|---|----------------|||||-||||---|--|||--|--  1 [S] COG4121 Uncharacterized conserved protein
|||------|--------------------------------------------------------  1 [H] COG4218 Tetrahydromethanopterin S-methyltransferase, subunit F
|-|-|||||-||------------------|------------------------|------||--  1 [C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits
|-------------------|---------|----------------------------|---|--  1 [R] COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif
|---------|-------------------------------------|------|--|-------  1 [H] COG4662 ABC-type tungstate transport system, periplasmic component
|-|------|--------------------------------------------------------  1 [R] COG4740 Predicted metalloprotease
|-|---||----------------------------------------------------------  1 [S] COG4743 Predicted membrane protein
|-|------|---------------------------------------|----------------  1 [S] COG4744 Uncharacterized conserved protein
||||--------------------------------------------------------------  1 [S] COG4746 Uncharacterized protein conserved in archaea
|-|-----|---------||----------------------------------------------  1 [C] COG4802 Ferredoxin-thioredoxin reductase, catalytic subunit
|-|------|--------------------------------------------------------  1 [R] COG4827 Predicted transporter
|-|-----|---------------------------------------------------------  1 [S] COG4855 Uncharacterized protein conserved in archaea
|-|-----|---------------------------------------------------------  1 [S] COG4871 Uncharacterized protein conserved in archaea
|-|-----|---------------------------------------------------------  1 [S] COG4883 Uncharacterized protein conserved in archaea
|-|---------------------------|-----------------------------------  1 [R] COG4892 Predicted heme/steroid binding protein
|-|----|----------------------------------------------------------  1 [S] COG4906 Predicted membrane protein
|||---------------------------------------------------------------  1 [J] COG4937 Predicted regulatory domain of prephenate dehydrogenase
||----||-|----------------|||-|--------------|---|-||--|---||-||--  1 [U] COG4962 Flp pilus assembly protein, ATPase CpaF
|||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||--  1 [E] COG4992 Ornithine/acetylornithine aminotransferase
|-|-----|-----------|---------------------------------------|-|---  1 [R] COG5012 Predicted cobalamin binding protein
|||---|-|-------||--|---|-------|-------------|-||-|------|-------  1 [C] COG5016 Pyruvate/oxaloacetate carboxyltransferase
||||||||||||||||--------------------------------------------------  1 [J] COG5256 Translation elongation factor EF-1alpha (GTPase)
||||||||||||||||--------------------------------------------------  1 [J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)
|--|----|-||------------------------------------------------------  1 [R] COG5258 GTPase
|-------|--||-----------------------------------------------------  1 [S] COG5440 Uncharacterized conserved protein