COGs Phylogenetic classification of proteins encoded in complete genomes

Clusters of Orthologous Groups of proteins (COGs) were delineated by comparing protein sequences encoded in complete genomes, representing major phylogenetic lineages. Each COG consists of individual proteins or groups of paralogs from at least 3 lineages and thus corresponds to an ancient conserved domain.

66 genomes 38 orders 28 classes 14 phyla Unicellular clusters     FTP Initial version Science 1997 Oct 24;278(5338):631-7, BMC Bioinformatics 2003 Sep 11;4(1):41. Euryarchaeota Methanobacteriales   Mth Methanococcales   Mja Halobacteriales   Hbs Thermoplasmatales   Tac Tvo Thermococcales   Pho Pab Archaeoglobales   Afu Methanopyrales   Mka Methanosarcinales   Mac Crenarchaeota Thermoproteales   Pya Sulfolobales   Sso Desulfurococcales   Ape Ascomycota Saccharomycetales   Sce Schizosaccharomycetales   Spo Microsporidia Apansporoblastina   Ecu Aquificae Aquificales   Aae Thermotogae Thermotogales   Tma Cyanobacteria Nostocales   Nos Chroococcales   Syn Deinococcus-Thermus Deinococcales   Dra Fusobacteria Fusobacterales   Fnu Spirochaetes Spirochaetales   Tpa Bbu Chlamydiae Chlamydiales   Ctr Cpn Actinobacteria Actinomycetales   Cgl Mtu MtC Mle Firmicutes Clostridiales   Cac Bacillales   Sau Lin Bsu Bha Lactobacillales   Lla Spy Spn Mycoplasmatales   Uur Mpu Mpn Mge Proteobacteria Pseudomonadales   Pae Enterobacteriales   Eco EcZ Ecs Ype Sty Buc Xanthomonadales   Xfa Vibrionales   Vch Pasteurellales   Hin Pmu Burkholderiales   Rso Neisseriales   Nme NmA Campylobacterales   Hpy jHp Cje Caulobacterales   Ccr Rhizobiales   Atu Sme Bme Mlo Rickettsiales   Rpr Rco Upcoming microbial genomes genomes genera orders classes phyla 261 126 63 33 17 [N]   Nano [A]   Euryarchaeota (8) *   Methanobacteria *   Methanococci *   Methanomicrobia *   Halobacteria *   Thermoplasmata *   Thermococci *   Archaeoglobi *   Methanopyri [R]   Creno (3) [D]   Deinococcus (2) [T]   Actinobacteria (3) [P]    Proteobacteria (26) α (6) 6 β (5) 5 γ (10) 10 δ (4) 4 ε (1) 1 [O]   Other (9) *   Bacteroidetes *   Chlorobi *   Fusobacteria *   Aquificae *   Chloroflexi *   Thermotogae *   Planctomycetes *   Spirochaetes *   Chlamydiae [F]   Firmicutes (7) Mollicutes (3) Bacilli (2) Clostridia (2) [C]   Cyanobacteria (4) *   Gloeobacteria *   Nostocali *   Prochlorali *   Chroococcali

Eukaryotic Clusters    FTP Code Name Abbreviation A Arabidopsis thaliana (thale cress) ath C Caenorhabditis elegans (worm) cel D Drosophila melanogaster (fruit fly) dme H Homo sapiens (human) hsa Y Saccharomyces cerevisiae (baker yeast) sce P Schizosaccharomyces pombe (fission yeast) spo E Encephalitozoon cuniculi (Microsporidia) ecu Upcoming eukaryotic genomes O Oryza sativa (rice) osa Q Anopheles gambiae (mosquito) aga Z Pan troglodytes (chimpanzee) ptr W Canis familiaris (dog) cfa M Mus musculus (mouse) mmu R Rattus norvegicus (rat) rno Ascomycota genomes including L Magnaporthe grisea mgr N Neurospora crassa ncr

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