| Teresa Przytycka | at 11:00 |
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Gene regulation in the context of variations in DNA sequence and structure
New experimental techniques facilitating various types of genome-wide measurements provide opportunity to gain new insights into functioning of cellular system. These experiments not only allow obtaining large scale view of accepted mechanisms, but also continue providing evidence of new levels of complexity of cellular systems. Perhaps most dramatic recent advances relate to gene regulation.
Gene expression and protein abundance is regulated by a complex superposition of biological mechanisms and we are still far away from having a regulation model that accounts for all of them. In this talk I will describe recent contributions of our group directed towards understating of various aspects of gene regulation. First, I will briefly outline a collaborative work directed towards in vitro study of role of non-B-DNA structures on gene regulation (a more complete picture will be presented in an upcoming seminar by Damian Wojtowicz). Subsequently, I will outline the results of another collaborative study on the relations between sequence variations and recombination. Finally, will discuss our studies related to impact of sequence variations on gene expression including our recent studies on genotype-gene expression associations and our new approach to uncovering pathways dys-regulated in complex diseases.
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