NCBI Special Seminar, Friday, April 24From: Ovcharenko, Ivan (NIH/NLM/NCBI) [E]
Sent: Wednesday, April 15, 2009 1:05 PM
To: NLM/NCBI List ncbi-seminar
Subject: NCBI Special Seminar, Friday, April 24

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A postdoctoral candidate, Badri Padhukasahasram from Navigenics, will present a seminar 
“Pre-symptomatic risk assessment for complex genetic diseases” at 11AM on Friday, April 24
in the B2 NCBI Library. 

Abstract
The prevalence of common chronic non-communicable diseases far overshadows the prevalence of both monogenic and infectious diseases combined. Common SNP variants account for a portion of the genetic risk for common diseases and when used in context will allow for more personalized and focused exposure mitigation, early detection, and early intervention paradigms. We introduce a novel measure called the genetic composite index (GCI) and demonstrate its predictive value as a clinical classifier. GCI considers only summary statistics of the effects of genetic variation and hence does not require the results of large-scale studies simultaneously assessing multiple risk factors. Combining GCI scores with environmental risk factors should provide an additional tool for clinical decision-making.