From: Wolf, Yuri (NIH/NLM/NCBI) [E]
Sent: Tuesday, March 03, 2009 10:07 AM
To: NLM/NCBI List ncbi-seminar
Subject: Reminder: CBB seminar in ~50 min

Time:  Tuesday, March 03, 11:00
Place: NCBI Library B2/38A

Computational analysis of translation initiation efficiency of mammalian 
mRNAs.

Yuri I. Wolf

Theory predicts a high importance of translation initiation efficiency 
(TIE) for highly expressed proteins. To test this prediction we develop 
a celluar automaton model of ribosome and estimate TIE for a 
genome-scale set of human and mouse mRNA. We find that TIE values are 
moderately conserved between orthologous genese in human and mouse but 
only weakly correlate with gene expression level and evolution rate.