From: Addess, Ken (NIH/NLM/NCBI) [E]
Sent: Wednesday, January 07, 2009 6:12 PM
To: NLM/NCBI List ncbi-seminar
Subject: Tuesday Jan 13th 11am CBB seminar

Tuesday, January 06, 2009

11 AM, B2 Library

Kenneth J. Addess

Challenges to Keeping MMDB Updated and Accurate

The Molecular Modeling Database (MMDB), Entrez's database of experimental derived 3-dimensional structures, provides links to many 
databases in Entrez, including Pubmed, Protein, CDD, Pubchem, Taxonomy and so on. Thus, MMDB is an important resource for molecular 
biologists looking to understand the role of structure in functional annotation.  The effectiveness of MMDB as a tool for molecular 
biologists depends on its information being accurate and updated in a timely fashion.  Global changes to the data at the RCSB Protein 
Data Bank (PDB) from which MMDB is updated and an increase in the number of structures released by the PDB has presented challenges 
in keeping MMDB accurate and updated.  I will discuss what we have done to meet these challenges.