Computational Biology Branch
NCBI CBB Home Page T. Przytycka’s Research Group		Teresa M. Przytycka’s research group Algorithmic and Graph Theoretical methods in Computational and Systems Biology Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive assessment. Group members Teresa Przytycka Raja Jothi Collaborators L. Aravind, David J. Lipman In highly conserved widely distributed ortholog groups, the main evolutionary force is assumed to be purifying selection that enforces sequence conservation, with most divergence occurring by accumulation of neutral substitutions. Using a set of ortholog groups from prokaryotes, with a single representative in each studied organism, we asked the question if this selective pressure is acting similarly on different sub-groups of orthologs defined as major lineages (e.g. proteobacteria or firmicutes).