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Computational Biology Branch

 

 

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Algorithmic and Graph Theoretical methods in

Computational and Systems Biology

Teresa M. Przytycka

 

 

Sample Projects

Biological Networks and Protein Interaction

o      Analysis of overlapping  Protein Complexes

o      Predicting domain-domain interactions from PPI network

o      MORPH- predicting protein interactions by searching tree automorphism space

o      RCDP – predicting domain-domain interaction from co-evolution principle

o      Separating co-speciation from functional co-evolution in interacting domains

o      DOMINE – a data base of protein domain interactions

o      Discovering functional linkage using phylogenetic foot printing

Evolution of Protein Sequence and Proteins Sequence Analysis

o      Graph theoretical insight into evolution of multidomain proteins   

o      COCO-CL-hierarchical clustering of Homology Relation

o      Study of selective pressure acting on conserved ortholog groups

Structural Biology

o      Structure Comparison by Projection Methods

o      Predicting beta-sheet topology

o      Protein folding simulations  

Phylogenetics

o      Evolutionary trees and graph motifs

o      Support for the Coelomata hypothesis from intron pattern conservation