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We study properties of
multidomain proteins from a graph theoretical perspective. In particular,
we demonstrate connections between properties of the domain overlap graph
and certain variants of Dollo
parsimony models. We apply our graph theoretical results to
address
several interrelated questions:
do proteins acquire new domains infrequently, or often enough that the same
combinations of domains will be created repeatedly through independent
events? Once domain architectures
are created, do they persist? In
other words, is the existence of ancestral proteins with domain
compositions not observed in contemporary proteins unlikely?
Our experimental results indicate
that independent merges of domain pairs are not uncommon in large
superfamilies.
DATA:
dommain_cluster_descriptions
mouse_arch_distr
mouse_dom_distr
nr90_arch_distr
nr90_dom_distr
nr90_pseudofamId_domNr_arch_Nr
mouse_pseudofamId_domNr_arch_Nr
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