Protein-protein interactions and networks:
identification,
analysis and prediction
Editors: Anna R. Panchenko
and Teresa
M. Przytycka
Publisher: Springer-Verlag
Disclaimer: The enclosed
information is subject to changes
Protein-protein interactions play a pivotal role in most cellular processes, such as replication, transcription, translation, signal transduction and others, while distortion of native protein interfaces can lead to the development of many diseases. Understanding of general of global and local properties of protein interaction networks as well as the mechanisms of interaction specificity at molecular level is necessary for the full understanding of biological processes. To decipher the global picture of protein interactions in the cell, different experimental techniques have been developed, some of them are designed to characterize the details of individual interactions while others are advanced to identify interactions on the genome-wide scale.
Motivated by the unprecedented amount of the diverse data on this important subject, the authors of the book aim to integrate different approaches from bioinformatics, biochemistry, computational analysis and systems biology to remedy the lack in a global view on this problem. “Protein-protein interactions and networks: identification, analysis and prediction” will combine the descriptions of experimental techniques and will expound on different computational algorithms for network analysis and prediction of protein and domain interactions.
Chapter 1. Experimental
methods of protein interaction identification
Peter Uetz, TIGR
Chapter 2. Protein
and domain interaction databases and data integration
Anna Panchenko and Benjamin Shoemaker, NCBI, NIH
Chapter 3. Protein-protein
recognition, hot spots
Ruth Nussinov, NCI, NIH
Chapter 4. Computational methods to predict protein interaction partners
Alfonso
Valencia1 and Florencio
Pazos2
1Spanish National
Cancer Research Centre
2 Computational
Systems Biology Group CNB-CSIC,
Chapter 5. Prediction of domain-domain and domain-peptide interactions from protein interaction networks
Katia
Guimarães1 and Teresa
Przytycka2
1 Federal
University of Pernambuco,
2 NCBI/NIH
Chapter 6. Characterization of the structures of macromolecular assemblies
Andrej Sali,
Chapter 7. Topological and dynamical properties of protein interaction networks
Sergei Maslov, Brookhaven National Laboratory
Chapter 8. Prediction of protein function from protein interaction networks
Mona
Singh,
Chapter 9. Comparison
of protein interaction networks and their conservation in evolution
Eytan
Ruppin, Roded Sharan and Nir
Yosef,