NCBI

Description: Description: Description: Description: Description: Description: Description: Description: back to NCBI homepage

Description: Description: Description: Description: Description: Description: Description: Description: back to NCBI homepage

SITE MAP

CBB
Home Page

 

Description: Description: Description: Description: Description: Description: Description: Description: http://www.ncbi.nlm.nih.gov/corehtml/spacer10.GIF

  

 

AlgoCSB: Algorithmic methods in Computational and Systems Biology

Teresa Przytycka, head

 

Teresa M. Przytycka, PhD

Senior Investigator

NCBI, NLM, NIH


Computational Biology Branch
Building 38a; Room8S812

8600 Rockville Pike
Bethesda, MD 20894


Tel: 301-402 1723; Fax: 301-480-9241
Email: przytyck@ncbi.nlm.nih.gov

 

Info in Intramural Research Program

 

IRP editorial: Algorithms for life

 

 

 

Principal Investigator

Publications

Software and data

Group Members

(and some group pictures)

Lecture notes

Book Chapters

 

 

Research Interests

The research in AlgoCSB group concentrates on computational modeling and analysis of biological processes, with emphases on hypothesis and theory-driven questions that are enabled by large-scale data analysis using (but not limited to) graph theoretical and algorithmic approaches. We frequently look at these processes through evolutionary lenses, focusing on evolutionary forces that shaped biomolecules on sequence, structure, and network levels. We are particularly interested in the dynamical properties of biological systems including spatial, temporal and/or contextual variation and exploring how such variations are impacting gene expression, how they affect network topology, function, and the phenotype of the organism. Specific research topics include:

  • Systems Biology Approaches to study Genotype-Phenotype relationship
  • Molecular interactions and networks
  • Gene regulation
  • Protein and genome evolution
  • Protein, DNA and RNA structure

Major Current Projects, key collaborators, and links to representative papers

         Systems/network analysis of cancer

         Dynamics of DNA structure (with David Levens, NCI; Craig Benham UC Davis)

         Methods for analysis of HT-SELEX (with Zuben Sauna, FDA and Eli Gilboa U. Miami)

         Systems analysis of copy number variations and gene regulation in fly (with Brian Oliver, NIDDK)