Chapter 4. Computational Methods to
Predict Protein Interaction Partners
Alfonso Valencia & Florencio
Pazos
Introduction
Computational Methods vs.
Experimental Techniques
Performance comparison
Computational methods based
on sequence and genomic information
Phylogenetic profiling
Similarity
of phylogenetic trees
Conservation of gene neighboring
Gene fusion
(correlated mutations, domain composition, …)
(synthetic lethality,
similarity of expression profiles, …)
Discussion and Future Trends