Anna Panchenko Associate Investigator National Center for Biotechnology Information National Institutes of Health Tel: 301-435-5891 Email: panch@ncbi.nlm.nih.gov

Cellular regulatory mechanisms provide a sensitive, specific and robust response to external stimuli. Many signaling pathways involve a dense network of protein-protein interactions and hence the analysis of protein interactions, networks, and pathways is essential for understanding biological mechanisms on a molecular level.

We are interested in fundamental problems of biomolecular recognition, mechanisms of evolution of protein interactions and the role of these interactions in cellular regulatory mechanisms. We explore the vast amount of sequence and structure data on protein complexes, perform comparative modeling to test causal hypotheses and develop methods to predict binding interfaces, interaction partners and scenarios of protein evolution.