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Leonardo Mariño-Ramírez, Ph.D.
Staff Scientist
NCBI, NLM, NIH
Computational Biology Branch
Building 38A, Room 6S614M
8600 Rockville Pike, MSC 6075
Bethesda, MD 20894-6075

Tel: (301) 402-3708
Fax: (301) 480-2288
E-mail: marino@ncbi.nlm.nih.gov

Curriculum vitae
Research Interests:
  • In silico identification of gene regulatory elements in eukaryotes.
  • Molecular and cellular interactions controlling gene expression in eukaryotes.
  • Evolution of eukaryotic gene regulatory elements.
  • Database design for biological data.

Publications in PubMed

Selected Publications:

  1. Tharakaraman K., Bodenreider O., Landsman D., Spouge J. L., Mariño-Ramírez L. (2008) The biological function of some human transcription factor binding motifs varies with position relative to the transcription start site. Nucleic Acids Research. In Press. [PubMed] [PDF]

  2. Piriyapongsa, J., Mariño-Ramírez, L. and Jordan, I. K. (2007) Origin and evolution of human microRNAs from transposable elements. Genetics. 176:1323-1337. [PubMed] [PDF]
    Evaluated by F1000 Biology

  3. Mariño-Ramírez, L., Jordan, I. K. and Landsman, D. (2006) Multiple independent evolutionary solutions to core histone gene regulation. Genome Biology. 7:R122. [PubMed] [PDF] Highly accessed in BMC

  4. Mariño-Ramírez, L. and Jordan, I. K. (2006) Transposable element derived DNaseI-hypersensitive sites in the human genome. Biology Direct. 1:20. [PubMed] [PDF]
    Evaluated by F1000 Biology

  5. Mariño-Ramírez, L., Hsu, B., Baxevanis, A. D. and Landsman, D. (2006) The Histone Database: a comprehensive resource for histones and histone fold-containing proteins. Proteins. 62:838-842. [PubMed] [PDF]

  6. Mariño-Ramírez, L., Kann, M. G., Shoemaker, B. A. and Landsman, D. (2005) Histone structure and nucleosome stability. Expert Review of Proteomics. 2:719-729. [PubMed] [PDF]

  7. Mariño-Ramírez, L., Tharakaraman, K., Sheetlin, S., Landsman, D. and Spouge, J. L. (2005) Alignments anchored on genomic landmarks can aid in the identification of regulatory elements. Bioinformatics. 21 Suppl 1:i440-i448. [PubMed] [PDF]

  8. Mariño-Ramírez, L., Spouge, J. L., Kanga, G. C. and Landsman, D. (2004) Statistical analysis of over-represented words in human promoter sequences. Nucleic Acids Research. 32:949-958. [PubMed] [PDF]

  9. Jordan, I. K., Mariño-Ramírez, L., Wolf, Y. I. and Koonin, E. V. (2004) Conservation and co-evolution in the scale-free human gene co-expression network. Molecular Biology and Evolution. 21:2058-2070. [PubMed] [PDF]


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Revised: May 7, 2008.