Supplementary material
Natural history of the E1-like superfamily: Implication for adenylation, sulfur transfer, and ubiquitin conjugation.
A. Maxwell Burroughs, Lakshminarayan M. Iyer, and L. Aravind
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TABLE OF CONTENTS
I. Mega-alignment of all E1-like families
II. Alignments of domains fused to E1-like domains
A. U5C--UBA5 C-terminal domain
B. Apg7N--Apg7 N-terminal domain
C. CCTBP domain
D. TRS4-C domain
E. wHTH domain (N-terminal to PaaA, MccB, GodD, and Rv3196-like families)
F. McbD domain
III. Conserved gene neighborhoods
A. Gene neighborhoods of members of the ThiF/MoeB/MoeZ families
B. Gene neighborhoods of other families involved in cofactor and cysteine biosynthesis
C. Gene neighborhoods for families involved in secondary metabolite adenylation
D. Gene neighborhoods of newly-discovered CCTBP domain
IV. Lists of gis
A. Eukaryotic Ub/Ubl-conjugating families
B. Bacterial Ub/Ubl-conjugating families
C. Cofactor and cysteine biosynthesis-associated families
D. Secondary metabolite adenylating families
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I. Mega-alignment of all E1-like families
Gene identifier (gi) number of representatives from each of the 26 families are given at the right of the
aligned proteine sequences, along with the name of the species in which each sequence is found. Names of
individual families are listed at the left of the alignment.
Conserved features of E1-like proteins R finger G-rich loop adenylating residues D,N,R,K Mg coordinating D Insert #1 region CXXC motif Insert region #2 ExxK motif CXXC motif
Boundaries of above regions <----|---helix dyad---> <------> <-----extended loop---------> | |------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------->| * * thiolating cysteine |------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------->| | | | |
Conserved Sec. Structure with cons residues R Str1 Hel1 Str2 * ** * Hel2 Str3 Hel-3 Str4 * Hel-4 Str5 Str6 | | * Hel-5 * * Str7 Str8 * *
FINAL --HHHHHHHHH---HHHHHHHHH---EEEEE----HHHHHHHHHHH-------------EEEEE-----EEE----EEEEEE----------HH-HHHHHHHHH-------EEEEEE-----------------------------------EEEE--------------------EEEEEE-----HHHHHHHHHHHHHH----------------------------------EEEEE--EEEEEEEEEE----EEEE--------EEEEEEE-------EEEEEE-----EE---EEEEEEEE---E-------------------------EEEEEE---EEEEEE------------------EEEEEEEEEE-------------------------------------------------------------------------------------------------------EE---HHHH--------------------------------------------------------------------EEEE--------HHHHHHHHHH-HHHHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHH---HHHHHHHHHH-H-----------HHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH----------------------------------------------------------------------------EEEEEEEE--------------------------------\UBA1-N
63054800 Schizosaccharomyces_pombe_972h_ EGLYSRQLYVL---GHEAMKQMSQSNVLIIGCKGLGVEIAKNVCLAGV----------KSVTLYD-PQPTRIEDLSSQYFLTEDD---IGVPRA-KVTVSKLAELNQY--VPVSVVD--------------------------------ELSTEYLKN-----------------FKCVVVTET---SLTKQLEINDFTHKN-------------------------------HIAYIAADSRGLFGSIFCDFGENFICTDTDGNEPLTGMIASI---TDDGVVTMLEETRHGLENGDFVKFTEVKGMPGLND-------------------GTPRKVEVKGPYTFSIGS-VKDL--GSAG----YNGVFTQVKVPTK-------------------------------------------------------------------------------------------------------ISFKSLRESLKDPE---------------------------------------------------------------YVYPDFGKMMRPPQYHIAFQAL-SAFADAHEGSL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPRNDIDAA---EFFEFCKKIA-STLQFD---VELDEKLIKEISYQARGDLVAMSAFLGGAVAQEVLKATTSK-------------------------------------------------------------------FYPLKQYFYFDSLES------LPSSVTISEE----TCKPRGCRYDG|
18415207 Arabidopsis_thaliana EDLHSRQLAVY---GRETMRKLFASNVLISGMQGLGVEIAKNIILAGV----------KSVTLHD-ENVVELWDLSSNFVFTEED---IGKNRA-LASVHKLQELNNA--VAVSTLTG-------------------------------KLTKEQLSD-----------------FQVVVFVDI---SFEKATEIDDYCHSHQP-----------------------------PIAFIKADVRGLFGSLFCDFGPHFTVLDVDGEEPHSGIIASV-SNENPGFVSCVDDERLEFEDGNLVVFSEVEGMTELND-------------------GKPRKIKNVKPFSFTLEEDTSSY--GQYM----KGGIVTQVKQPKV-------------------------------------------------------------------------------------------------------LNFKPLREALKDPG--------------------------------------------------------------DFLLSDFSKFDRPPLLHLAFQAL-DRFSSQAGRF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFAGSEEDAQ---KLVEIAVDIN-EGLGDARL-EDVNSKLLRHLAFGSRAVLNPMAAMFGGIVGQEVVKACSGK-------------------------------------------------------------------FHPIFQFFYFDSVES------LPKEPLDAS-----EFRPQNSRYDA|
86565431 Caenorhabditis_elegans KNLYSRQIYTL---GESAMVNLRTASVLISGLGSVGVEIAKNLILGGV----------RHVTIHD-TKLAKWSDLSAQYYLRDAD---VGHNRA-TSCYERLAELNDS--VNVQVSTD-------------------------------ELTEEFVKT-----------------FDLVVLTDA---ARTAQRQIAAWTRAH-------------------------------NRRILITDARGVFSYIFNDFGDNFRIDDATGEQVREFFIEHI--DKTTGEVTTLENLFHGLEDGDHVTFSEVKGLTEING-------------------CEPLKITVKNASKFNIGDFAVSF--SDYK----EGGRCRQVKVPTS-------------------------------------------------------------------------------------------------------VSHVPFEKSLVEPE---------------------------------------------------------------FGIWDYAKFEYPSQLHALWTAL-YAFEEKYGRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAPRSTQDAA---LLKELIPSGT----------EEIPEKLIELFSFSASGNLVTVSSVVGGIAAQEAMKGVTHH-------------------------------------------------------------------MTPLKQWLHLDHVEVLPGDW-TSFDNSKLSET---DCQPRQSRYDG|
66826621 Dictyostelium_discoideum_AX4 DALYSRQLYAL---SHETMKKITSTSVLVVGLQGLGIEIVKDLSLAGV----------KSVTLYD-KELVEIKDLSSQFYFSPEQ--VGKVGRA-DACFQKVVDLNNY--VRIDVHNG-------------------------------ELSDEFLKK-----------------FNVVVLANQ---PLALQLKVNEFCHAN-------------------------------KIHFISVETRGVFGQLFNDFGEQFTITDTNGENPNAYMISSI-SQDKEGIVTVVEEQKLQLLDGDLVTFKEVNGMSALND-------------------LPPQKIKTISPLTFSIGD-TTNL--PPYT----SGGYVTEVKQPKV-------------------------------------------------------------------------------------------------------VDFKPLKNILESGE--------------------------------------------------------------NIFITDDFKFTQPTNLLAGFQAI-HKFAEKNKHM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPHNKEDAN---AVIEIAKGLL-KKPD-----DELDEKMITQLSFGAQGDIVPMQAILGGITAQEVLKACSGK-------------------------------------------------------------------FTPIHQLAFFDSVEC------LPEDLETLPEE---EFQPIGSRYDG|
54636758 Drosophila_pseudoobscura ESLYSRQLYVL---GHDAMRRMANSDILLSGLGGLGLETAKNVILGGV----------KSITLHD-TATCGPNDLSSQFYLSEAD---IGKNRA-EASCAQLAELNSY--VRTVSHTG-------------------------------PLTEEFLRQ-----------------FRVVVLTNS---DTAEQERIGKFAHEN-------------------------------GIALIIADTRGLFAKVFCDFGESFTIYDQDGAQPVSTMIASI-THDAQGVVTCLDETRHGFNDGDYVTFSEVQGMQQLNG-------------------CQPIKITVLGPYTFSIGD-TSSY--GEYK----SGGVATQVKMPKS-------------------------------------------------------------------------------------------------------ISFKSLEQASKEPE---------------------------------------------------------------FLISDFAKLESPATLHVAFNALSVYQKVNDGAL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPWNEADAN---CFLQFCKEIK----------SDVDEKLVLQFAKICAGNTCPMDAAVGGIVAQEVLKACSGK-------------------------------------------------------------------FTPIYQWLYYDALEC------LPVAGVTEA-----DAQPLGSRYDA|
23510338 Homo_sapiens EGLYSRQLYVL---GHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGV----------KAVTLHD-QGTAQWADLSSQFYLREED---IGKNRA-EVSQPRLAELNSY--VPVTAYTG-------------------------------PLVEDFLSG-----------------FQVVVLTNT---PLEDQLRVGEFCHNR-------------------------------GIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMV-TKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNG-------------------NQPMEIKVLGPYTFSICD-TSNF--SDYI----RGGIVSQVKVPKK-------------------------------------------------------------------------------------------------------ISFKSLVASLAEPD---------------------------------------------------------------FVVTDFAKFSRPAQLHIGFQAL-HQFCAQHGRP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPRNEEDAA---ELVALAQAVN-ARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGK-------------------------------------------------------------------FMPIMQWLYFDALEC------LPEDKEVLTED---KCLQRQNRYDG|
6678483 Mus_musculus ESLYSRQLYVL---GHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGV----------KAVTLHD-QGTTQWADLSSQFYLREED---IGKNRA-EVSQPRLAELNSY--VPVTAYTG-------------------------------PLVEDFLSS-----------------FQVVVLTNS---PLEAQLRVGEFCHSR-------------------------------GIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMV-TKDNPGVVTCLDEARHGFETGDFVSFSEVQGMIQLNG-------------------CQPMEIKVLGPYTFSICD-TSNF--SDYI----RGGIVSQVKVPKK-------------------------------------------------------------------------------------------------------ISFKSLPASLVEPD---------------------------------------------------------------FVMTDFAKYSRPAQLHIGFQAL-HQFCALHNQP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPRNEEDAT---ELVGLAQAVN-ARSPPSVKQNSLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGK-------------------------------------------------------------------FMPIMQWLYFDALEC------LPEDKEALTEE---KCLPRQNRYDG|
71024211 Ustilago_maydis_521 EGLYSRQLYVL---GHDAMKRMAASNVLVVGLRGLGAEIAKNVALAGV----------KSITIFD-PTPVSISDLGTQFFLRPED-ASSRVRRD-HATQPRLAELNTY--VPIRVLEDN------------------------------ELNQQILSR-----------------FQVVVMSDA---LYAEQLRINDMTHAS-------------------------------STHFISAEVRGLFGSVFTDFGPKFLCNDPTGEQPLSGMIVSIASEDEEGLVTTLDETRHGLEDGDYVSFTEVQGMDALND-------------------SQPRKVTVKGPYTFTIGS-TKGL--GQYK----QGGIFKQVKMPKE-------------------------------------------------------------------------------------------------------IAFKSLRESGKQPE---------------------------------------------------------------LLIADFAKFDRPAALHAGFQAL-SHFEHQNGRL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAPRNAQDAD---LLLQLTKQIV-QTCGQDP--ADLPEKVIRELAFQAQGDLSPMVAYIGGFVAQEVLKACSGK-------------------------------------------------------------------FHPLVQHLYVDSLES------LPDSVESLPES---EFAPTNSRYDG|
71411317 Trypanosoma_cruzi_strain_CL_Brener RQLYNRQEYVV---GVETQAKYGSTDVLVVGACGLGAEIVKNLALTGV----------RSIKIMD-SGTAILQDLGTNFFLTPQD---VGQPRA-DVVARRAQELNRF--VHITAVTS-------------------------------PL-HEVIPD-----------------VHVVVFVNQ---RTTALVGENALARKH-------------------------------DVKFVACESRGIVGCVFVDAGPSFSVLDPDGEETVSCIVTSV---SRDGVVSLHEDKKHECEVGSHIFFTGVVSPAAVNADIDPSTIHGRCQSAASPLLKLFEVAEVISPFILRLKDFEAAV--GNSPIEVGTGAYLHTTKRHVL-------------------------------------------------------------------------------------------------------MGFKDLEQSVADPTF-------------------------------------------------------------VSIFDSEEKVNAPATLHALFRAL-HDH----GTL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTTPTEVNS----LLNLAEAYHS-SCNS-----GHLDVEFSKKALSVIHGNLNPMACLIAGIASQEVLKVCSGK-------------------------------------------------------------------FTPIQQWLYYDARELLV----ARGEVAEADLR---PPSPTGSRYDK|
118383519 Tetrahymena_thermophila_SB210 ENLYSRQMAVY---GAETQGKLMKMKVFIYGLQGVGIEVAKNLVLAGP----------SQVVIYD-DNICKSVDQGVNFYIQEKH-VKNNSTRA-EASAEQLQQLNPY--CQVTILKG-------------------------------EIDTQVLSS-----------------YNVVVFTDY--FNKEKLIEFNNFCREK-------------------------------GIGFIYTANLGLYGCAFVDFGQKHKVFDNNGEDPKHSIVVSI-TQDKEGLVTTHEDKRHGLVDGDHVTFKEVQGMTEVND--------------------QVYKVTVKSPFTFTIAQDTSKF--KAYQ----REGIVQQVKVCEEI------------------------------------------------------------------------------------------------------QFNSLQQSLNNPIAPGKD----------------------------------------------------------CLEMCDFEKIGRPEQLHIILNGIFEFCKHNNGQLPQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLNQDHSKQLKE---IVHKLLESNK-ADASNKFKVEEIPDELIQNVSLYARAHISPVASFWGGVVAQEIVK-FTGK-------------------------------------------------------------------FTPLRQWLHHEVFEC------LPDSQVTREV-----VDSQNGHYVA|
84994606 Theileria_annulata_strain_Ankara TNLYSRQIGTF---GFDMMGKLQKLNVLIIGMKSTGIEIAKNLALMGV----------ESIKILD-NDVVQRRDLGVNYFVRASS--VGKESIA-SACLHNLKDLNRN--VDIKVIN--------------------------------NVNEELVVG-----------------NDVVVCCDQ---NVEVLKNLNRICRANSLGK---------------------------RIGFIACDTFGMIGSVFVDFGDNFISFDPTGTELKTGIIESI-TNDKEGLVTLITDGVIDFQTGDYVRFSEIEGMTELNN-------------------KEPVQIKVNSKNSFLIGD-LSHY--TPHT----SGGLVTEVRYPKR-------------------------------------------------------------------------------------------------------IEFRSYEDCVLNPS-STG----------------------------------------------------------CLYTIDYSLVNRAEQLHWITMG--YKH----GSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPKSTL---TNAQMMNSNA-KSCGV----ESVDEELFKSFFSQVNFKVPPLASFIGGIVAHEVIK-FTGK-------------------------------------------------------------------YHPINQWLYVDFSLP------KEMLSGDFS------GRGFDERYFD|
67623861 Cryptosporidium_hominis_TU502 TNLYSRQIGTL---GLEAMGKLIKLRVLIVGLRGLGVEIAKNIILAGP----------KSITLVD-DEICSFSDMGANFYITEND-VKKGAKRS-DACLNKLASLNEY--VQVTVFHG-------------------------------EITSQLIFN-----------------HDVIVCADV---PLSLQIKYNELCRDHTP-----------------------------NIGFISANSLGLCGSVFVDFGDSFNVFDGNGEEPKSAIIAKISRGKETTSITCLAEKLLPFQEGDYVMFREVQGMTELNG-------------------TGPHKIISTGKHQFTIQLDSSMF--REYE----REGLVTQVKVPINY------------------------------------------------------------------------------------------------------SFRSLRDALEYPICDEQG----------------------------------------------------------ILIVPDLNKFGRSEQLFFSINSV-LKYSDIKGSRPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTDLQAINECHSLAVEMNE---NSKKKQDSND-EKKEFVISVSSIDRDILEKVCKYSRCCISPMAAFLGGIAAQEIVK-FVGK-------------------------------------------------------------------YTPLRQFFFFDAFEQL-----DLISNETHTKE---EFMPLGSRYDD|
123482348 Trichomonas_vaginalis_G3 TNLYSRQIYAL---GLEAIKKMSHASVLIAGMGGLGVEIAKNIILMGV----------KNVTIQD-TKNTTLEDIASQFYLTESD---IGKNRA-ESSFKKLAELNQH--VSVSLATC-------------------------------ELTNDFISK-----------------FDTIVLTDL--YPFSKLLEISDFCHQK-------------------------------NIKLIITQVSGLFGYVFNDFGEKFYVSEPKDEIPERFLIENI-TQDKDGIVTTSDYTRHGLYEGDTVKFEEVEGMEEVND--------------------KLFTVKPINPYKFSIGD-TSGF--HPYK-NTGSGGYCCQVNLPIT-------------------------------------------------------------------------------------------------------MDFPSLRDSLKAPE---------------------------------------------------------------VNLTDLVFFGRENEVISCFIAL-SKYIDES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEGPIDTA---KFTELAKKVA-NEYHFC---EEISNDVLSTFTYQAKTVITPMCAVFGGIVGQEVFKSISSK-------------------------------------------------------------------FTPIKSYYAISYIES------TVKDVKYEP---------LNDRFDT|
19173051 Encephalitozoon_cuniculi_GB_M1 ESLYSRQLYVV---GKEAMKKMMGSKVLVMGLDGLGQEVVKNVCLAGI----------SKVALFD-DRAVSEEDLCSGFYLRKED---IGKPRD-ASVVGRFRSMNEY--VDVDVVS----------------------------------DVNSFEG-----------------YDIVVACNE---SYGEQIRLNEMARKD-------------------------------GCMFIGCQVRGLFSQVFCDFGAEFVCVDRTGEIPASGMINDI---SEDGVMTVVDGQRHNLEDYDIIKITQCDEYEGKYFRVKA---------------VSPTQVMLQSIDGVRMFEEEMEF--KAEKFKPVYGGDFEQQKKPIM-------------------------------------------------------------------------------------------------------ISFKPLGRTIDEPG---------------------------------------------------------------ILGFNHEVEERSLVIHKCFVAL-GEYMEQSGQE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSGEGFLS---FFVKKYKSHF----------EF--EALIRSFGKQCGGMLMPMCSVIGGFVAQEVLKGVGSK-------------------------------------------------------------------FTPLHQFFYFDAVDV------IPNDPEDDG--------RDYGRYGP|
67463386 Entamoeba_histolytica_HM_1IMSS EAVLSRQLFTI---GKDAQIKMMNTKVLIAGLNGMGAEITKNVLLMSV----------KSVGLLD-NRNACLADLGTNFFLRKEH---IGHCIS-ESTYKQFQELNNN--VPVRVEKR------------------------------ELTDETLYND-----------------YDIIVLCYL--LSEKQSIYINELCRKH-------------------------------NVKMVYAVNRGPFTMIFNDFGDNFVVFDSNGETPLTYIVNEV----VGNTIQFIDENFCTLDVGNEVQLDEFSGLPGLNYSENG---------------GKTFKITKRTAYSIEIGD-LSQY--GKYI----KGGKVTEVKPTVT-------------------------------------------------------------------------------------------------------LHYKPLKERLNEPG--------------------------------------------------------------EITFTNMSKMERLRGYQTLYHGL-MIFMDKYGRS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKSHDEEDYK---QFKSIVEELH----------IDLDENIIKIFCYCNNGFFSPLDTAFGGIAAQEVLKAASGK-------------------------------------------------------------------YTPYCQYMFYDCLEI------LPDNYLELPK----EEFKDNGRYSG/
FINAL -HHHHHHHHHH---HHHHHHHHH---EEEEE---HHHHHHHHHHHH-------------EEEEE----EEE------EEEE-----------HH-HHHHHHHHH-------EEEEE----------------------------------------E-------------------EEEEEE-----HHHHHHHHHHHHHH----------------------------------EEEEE--EEEEEEEEEE---EEEEE---------EEEE-----EEEEE---------EE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE---EEEEEE---------------------------------------------------------------------HHHHH-----HHHHHHHHH-HHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH---HHHHHHHHHH--------------HHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------EEEEEE-------------EEEE------------------\SAE1/AOS1
9790247 Mus_musculus AAQYDRQIRLW---GLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGV----------KGLTMLD-HEQVSPEDPGAQFLIQTGS---VGRNRA-EASLERAQNLNPM--VDVKVDTE----------------------------DVEKKPESFFTK-----------------FDAVCLTCC---SRDVIIKVDQICHRN-------------------------------SIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPEAKRAKLDSSETTMVKKK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLFCPVKEALEVDW--------------------------------------------------------------SGEKAKAALKRT-APDYFLLQVL-LKFRTDKGRDPT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SESYKEDAEL---LLQIRNDVFD-SLGISP-------DLLPDDFVRYCFSEMAPVCAVVGGILAQEIVKALSQR-------------------------------------------------------------------DPPHNNFFFFDGMK-------GSGIVECLGPQ--------------|
60594167 Homo_sapiens (1y8qC) AAQYDRQIRLW---GLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV----------KGLTMLD-HEQVTPEDPGAQFLIRTGS---VGRNRA-EASLERAQNLNPM--VDVKVDTE----------------------------DIEKKPESFFTQ-----------------FDAVCLTCC---SRDVIVKVDQICHKN-------------------------------SIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVFCPVKEALEVDW--------------------------------------------------------------SSEKAKAALKRT-TSDYFLLQVL-LKFRTDKGRDPS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDTYEEDSEL---LLQIRNDVLD-SLGISP-------DLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQR-------------------------------------------------------------------DPPHNNFFFFDGMK-------GNGIVECLGPK--------------|
21436117 Arabidopsis_thaliana TALYDRQIRVW---GAGAQRRLSKSHVLVSGIKGTVAEFCKNIVLAGV----------GSVTLLD-DRLVTTEVFNANFLILPDENAYVGKTVA-EICCDSLKDFNPM--VHVSIEKG----------------------------DLSTLGVDFFEK-----------------FDVVVIGYS---SRATKKAVNEKCRNLAK-----------------------------DVAFYTVDCRGSCGEIFVDLQNYKYTKKKLDETVECE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTFPSFEEAVSVPW--------------------------------------------------------------KPMPRRT------AKLYFAMRVI-ELFEETEGRKPG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ECSLSD---LPRVLKLKKE-LCEGNSVSENHIPDILLERLVS-NNTEFPPACAIIGGILGQEVIKVISGK-------------------------------------------------------------------GEPLKNFFYFDAED-------GKGVIEDLSHKL-------------|
66814780 Dictyostelium_discoideum_AX4 AKIYDRSIRLW---GVDAQAKLRQSKVLFIGINGLMSEIIKNVVLAGV----------DSITLVD-DHIITTSDLSAHLFINEDS---VGKVIS-TESVFAISELNPL--VTIDVYDK----------------------------EIETMDDQFIKN-----------------YTMVVISDK---NLNNVSKVNSLCRKN-------------------------------NVSFIFSHSFGLKGLFFSDLNEFKYFTKTTTEPPKTETHI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIFKSFKESMGYDW--------------------------------------------------------------SKTNSRT------PLPFFALSTL-YQFEEKHNRVPD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISDSDLSEL---KSIINSSIEK-FNLKNTD--SNKYFEETKDLLNKMNIEISPVCAIVGGIVGAEIIKIITQN-------------------------------------------------------------------MQVLNNFFFYDGVK-------GTGLVEQF-----------------|
6325438 Saccharomyces_cerevisiae IALYDRQIRLW---GMTAQANMRSAKVLLINLGAIGSEITKSIVLSGI----------GHLTILD-GHMVTEEDLGSQFFIGSED---VGQWKI-DATKERIQDLNPR--IELNFDKQ----------------------------DLQEKDEEFFQQ-----------------FDLVVATEM---QIDEAIKINTLTRKL-------------------------------NIPLYVAGSNGLFAYVFIDLIEFISEDEKLQSVRPTTVGPISSNRSIIEVTTRKDEEDEKKTYERIKTK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCYRPLNEVLSTATL-------------------------------------------------------------KEKMTQRQLKRV-TSILPLTLSL-LQYGLNQKGKAISFEQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKRDAAVWCE---NLGVPATVVK-DDYIQQ-------------FIKQKGIEFAPVAAIIGGAVAQDVINILGKR-------------------------------------------------------------------LSPLNNFIVFDGIT-------LDMPLFEF-----------------|
2330802 Schizosaccharomyces_pombe IALYDRQIRLW---GFNAQQALKQSRVLLITASPLANEIAKNLVLSGI----------GKLCVLD-SMTVYEKDVEEQFFIEASD---IGQLRA-NVFKKKLHELNPL--VEIDTDTS----------------------------LISEIDEGKISK-----------------FSMVIATQL---DYEEFCRINELTRIC-------------------------------NASFYATSCFGLYGFAFCDLINHNFAIDRVVDNTKVEEDMF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVQKPMKEAFQSIL--------------------------------------------------------------GETLKPRLAKKI-PTLYPAMLSL-LKSKKSDPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIRQVCIEQK---------LNEK-TVLNGE---------FLSKFSSNISFQWTPVMSVVGGVVSQDALNSISKK-------------------------------------------------------------------QFPIDNFWIFDAES-------GLAPIYRL-----------------|
71005124 Ustilago_maydis_521 --------------GLAAQTRLRCAHILILGWNGIATEILKNTVLSGI----------GSITILDPTCIDGSVDLLSGFFFRDEE---VGQPKS-QGPLGRVRALNPL--VKVNGIADMASYTKLMQG------------------GKEAQAWIMERGVDVVVAGTPLP------EESGVAHVG---SRASLVKLNETTRSA-------------------------------GVKFFFSATCGFGGFYFADQITHDYLLEKAAPPPTANSTTSTDTSETQRVKKR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNFVPLSSSLATKW--------------------------------------------------------------HLSERQQRRTRI-PLDWFIWLAL-TDLETRLAPDSA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTTLSSAALK---ERTEALIREKGLVPNVILANHEDSVFDIVAAQGAMGVTLSPVAAVVGGILSQDILNSIGGR-------------------------------------------------------------------EEPVVNWLFLNMDA-------SGATTVHRIGE--------------|
124804829 Plasmodium_falciparum_3D7 EKIYDRQLRLW---GVKAQNRMMKSNVLVVGLSGINIELCKNLILNGI----------N-ITIID-NNIVDEEDIENIFFLNEHD---MKEYMS-VPIFKELKSINQL--INIKSFIGHINLDTNNIIIEKELMYKDNEIIQEEKIINDCSYDICDYITNYT-------------CVCISCEDY---PLYKLTKINEICHEK-------------------------------NIGFFANMCHGKYAFLFSDFGKHIIEESYYKIKNDDNKKGNDNSIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQYCTLSHFLKVPF--------------------------------------------------------------SNL-DKKTN-----DIIYYVFAL-ILYEQDKKMNK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNKQIDEQEF---LNFYNKLANK-TNTQNP-----------TELCKTYKINFSPSCSIMGGVTSQEIRKFISRQ-------------------------------------------------------------------HESIPNFCVFDMNQ-------NIV-CTSMIK---------------|
118364135 Tetrahymena_thermophila_SB210 ELQVYDRQRFI---GVEVQKRLLNAKVFITPANGVNTELAKNLILCGT----------N-ISIAD-NEIVNQDDVETNFLIAPHD---LGKIRG-EVVKAKLQDMNPM--VKIDLYQTFDIKSFYQKYILENN-------------VDCSFTKEFFNQ-----------------FNIITSSTP---IFKEMELYDEISHFL-------------------------------NIPYYNQLCCGLYGFFYVSLGSLFELTQAKPKIQKTKIVQGKLVKEPILFEY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHKVSLKSEKLKNF--------------------------------------------------------------LGTNPRGSK-----PVYHAIQMM-KRAEDLNLRYDP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNHSEENQKV---LEQIVELAQE-KIKNEE------DREFYTNFAKFYGIEHCPVYSVIGSVASQEFIKVIAKD-------------------------------------------------------------------KMPALNWFVYDSQI-------GYGKIESQTDKIDATYVDLPELTRK|
116805810 Drosophila_melanogaster NELYDRQIRLW---GLESQKRLRTAKILIAGLCGLGAEITKNIILSGV----------NSVKLLD-DKDVTEEDFCSQFLVPRES---LNTNRA-EASLTRARALNPM--VDISADRE----------------------------PLKEKTSEFFGQ-----------------FDVVVVNGA---TNEELLRIDTICRDL-------------------------------GVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVDNSEKKKKYETVSIPTQRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VDYPGYSAWLDFDV--------------------------------------------------------------TEPSYLRKLKRN-GPGVLLLSVL-QKFRTTHKRDPS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YKTRE---ADLELLRGIR-DELLPN-------SILGDEALGLIFAQISPAVAVVGGVVAQEVIKVVTKL-------------------------------------------------------------------EAPHRNLFVFDPET-------CAGYVEAIGAK--------------/
1tt5A.pdb (UlA1) HHHHHHHHHHHEEEEEE-HHHHHHHHHHHHH--------------EEEEEE-----HHHHHHHH-------------HHH-HHHHHHHHH---------EEE--HHH-------------------------HHHHH--------------------------EEEEEE----HHHHHHHHHHHHHHH---------------------------------EEEEEEEE-EEEEEEEE---EEE-----------------HHHHHHHHHH--- ----HHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHH----------HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH-----------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHH----EEE---HHHHHHH----HH----------------------------------------------------------HHHHHHH---H--HHHHHHHHHH-HHHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-HHHHHH--HHHHHHHHHHH-HH----------HHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHH--------------------------------------------------------------------------EEEEEE------------EEEEE-----------------\UlA1/APPBP1
1tt5A EQKYDRQLRLW---GDHGQEALESAHVCLINATATGTEILKNLVLPGI----------GSFTIID-GNQVSGEDAGNNFFLQRSS---IGKNRA-EAAMEFLQELNSD--VSGSFVEESPE-------------------------NLLDNDPSFFCR-----------------FTVVVATQL---PESTSLRLADVLWNS-------------------------------QIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYD--------DHSHTPWIVIIAKYLAQWYSE--TNGRIPKTYKEKEDFRDLIRQGILK-----PEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDE--------------------------------------------------------IISSMDNPDNE--IVLYLMLRAV-DRFHKQQGRYPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSNYQVEEDIG--KLKSCLTGFLQ-EYGLS----VMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQ-------------------------------------------------------------------FVIFNNTYIYSGM---------SQTSATFQL---------------|
24662483 Drosophila_melanogaster SKKYDRQIRLW---GEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGI----------GGFTVAD-GSTVKEEDLGNNFFLDSSY---LGKSKA-LACMQLLQELNPD--VNGDYVDESAD-------------------------FLLANRPNFFDS-----------------FDLVIASNL---NEQTLLLLAERLWEL-------------------------------NVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTE--------VTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEM-------KADEENYEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVIRGTRIAEEYEKSSRL-----------------------------------------------------------LPLVEDNELQGNLTAYNFALRAY-ERFLSECGNIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ECI--VEQDIG--RLKSIAAKMLS-DLGMH----ATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQ-------------------------------------------------------------------YKPIDNTFIYNAI---------TTESVTLKL---------------|
41053883 Danio_rerio EQRYDRQLRLW---GDHGQEALENAHVCLINATASGTEILKNLVLPGI----------GAFTIVD-GHKVSGEDVGNNFFLSSSA---IGKNRA-QAATELLQELNSD--VSGNFVEESPD-------------------------KLLDNDCEFFHR-----------------FSLVIAVQL---PESTCLGLGAVLWEA-------------------------------GVPFLVCRTYGLIGYMRLIVKEHTVVESHPDNALEDLRLDQPFTELKRHVESYDLDNMEK-KDHSHTPWIIVVARYLEKWYNE--NNSQLPKNYKEKEAFRQLLREGILKNENGGLEDEENFEEAIKNVNTALNPTKISSGTQDIFNAEQCENITSQSSSFWVMAHGVRDFVQNEGNGNLPVRGSIPDMIADSDKFIKLQNVYRDKAMRDAAVVSKHVEMLLQSVGKTPESISEQEIKLFCKNAAFLRVVRCRSLADEYSVDTFNKDE--------------------------------------------------------ITSCMDSPDSE--MVLYLMLRSV-DRFYQQHSRYPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYNYQVEEDIN--KLKLCVNSLLQ-EYSLN----VNVKDDYIHEFCRYGAAEPHTVAAFLGGSAAQEAIKIITHQ-------------------------------------------------------------------FVPFNNTFLYNAM---------SQTSATFQL---------------|
66806481 Dictyostelium_discoideum_AX4 TDKYDRQLRLW---GEDGQSKLERSHILLLNGSATGTETLKNLVLPGI----------GSFTVVD-NKKVTESDLGNNFFVERSS---LGKPRA-TVVCELLRELNDR--VKGFSVEECPI-------------------------HLINNNISFFKD-----------------FSLVVANRL---SEEALLTLSQYLTEQ-------------------------------NIPLLITNSYGYIGYLRISTPEHQIIESKPDDPIDDLRIYNPFKQLVDMADALELDKLNT-QQHSHVPYVLLLIKFLKEWRST--HNDKMPETRAEKDEFKKFFNSHSW------SADEMNFVEGIQNLLKYIQPPRVPGDVQNLLKDPKT-NITENSDDFWVLVAALKEFM-TNNDNTLPLHGNVPDMTSETHNFIQLQKGYQEKALADLSEFSGYVDQILTKVGKS--SISSDLVKKFCKNTRFLNIIRYRTISEEYNQPKT------------------------------------------------------------NLIKSELEQADTVMVFYILLRGI-DKFYKTYHKYPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSDD-FESDIP--LLKTVITQYLA-EINISN---DLVKDDYIAEFVRFGGSELHNIASLMGGVTSQEIIKLITHQ-------------------------------------------------------------------YTPLNNTFIFNGI---------NSTAGSYNL---------------|
15220442 Arabidopsis_thaliana KTKYDRQLRIW---GEVGQAALEEASICLLNCGPTGSEALKNLVLGGV----------GSITVVD-GSKVQFGDLGNNFMVDAKS---VGQSKA-KSVCAFLQELNDS--VNAKFIEENPD-------------------------TLITTNPSFFSQ-----------------FTLVIATQL---VEDSMLKLDRICRDA-------------------------------NVKLVLVRSYGLAGFVRISVKEHPIIDSKPDHFLDDLRLNNPWPELKSFVETIDLNVSEPAAAHKHIPYVVILVKMAEEWAQS--HSGNLPSTREEKKEFKDLVKSKMV------STDEDNYKEAIEAAFKVFAPRGISSEVQKLIND-SCAEVNSNSSAFWVMVAALKEFVLNEGGGEAPLEGSIPDMTSSTEHYINLQKIYLAKAEADFLVIEERVKNILKKIGRDPSSIPKPTIKSFCKNARKLKLCRYRMVEDEFRNPSVTEIQ--------------------------------------------------------KYLADEDYSGA--MGFYILLRAA-DRFAANYNKFPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFDGGMDEDIS--RLKTTALSLLT-DLGCNG---SVLPDDLIHEMCRFGASEIHVVSAFVGGIASQEVIKLVTKQ-------------------------------------------------------------------FVPMLGTYIFNGI---------DHKSQLLKL---------------|
115456233 Oryza_sativa_japonica_cultivar_grou KTKYDRQLRIW---GDQGQAALEKASICLLTCGPTGTEAMKNLVLGGV----------GSVTVVD-GSKVEQSDMGNNFLLDAEC---LGQSRA-KSVCSFLQELNDA--VNAKFVEESPL-------------------------ALIDTNPSFFSQ-----------------FTVVIATQL---PERSLLKLDDICRKA-------------------------------NIVLVAARSYGLTGLVRISVKEHNVIESKPDHFLDDLRLHNPWVELKQFAKSIDINDKDP-VVHKHTPYIVILVRLAEKWADA--HDGRLPSTRQEKNEFKALIREYML------NLDEENYKEAVESSYKVSVTPGISDEIRQIIDDSSA-EVNSSSSDFWVLVAALKEFIANEGNGELPLEGTIPDMTSLTEYYVSLQKIYQAKAESDCLALEHHVKDILKRIDRDPDSISRAYIKTFCKNARKLRVCRYRSMEEEFSSPVLSEVQ--------------------------------------------------------IYFTDEDYCFA--MNFYVLLRAV-DRLAANYNRCPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFESEIDEDVP--RLKTAAVSVMS-EMGMNG---APLSEDLITEMCRFGGAEIHPVAAFIGGVASQEVIKLVTKQ-------------------------------------------------------------------FVPLLGTFIFNGI---------DHKSQVLAL---------------|
58261726 Cryptococcus_neoformans_var_neoform AERSVHSVRLW---ASAGQRSLEQARVLLVGCDAAGSQSLKNLVLPGI----------SQFTILS-SKITTAQDVATNFFLHPDS---IGSNIA-QESVKYLQELNPA--VKGEAHMEDPA-------------------------LIIKTNPRFFLS-----------------FALIILSNV---EPYLENQIAEILWEASSSVDGP------------------------DIPLIAIRNSGFISRVQIQLREHTVVDSHPDTT-HTLRIDQPFPALEQHARSLDFANMDS-MEHSHIPWVVLLVRAASLWKES--HGGKLPETNEEKAEFKEKLKAEKI------KEDEENYDEAMAQAYRVWIKSELPWEIKCLLDDETVKNISTNSKNLHILLHTLSQYI-IPAPHLPPTSPSLPDMHSSTAHYVALQNMYKAQYQADLKQFKSLLNEVLRNIGLPTDTVPDEELEGFVKNVGGVGIIKGTPLSDSKNIRGLLPTE--------------------------------------------------------LENFDEEIDSATCLSMYLALLAS-ETFFESEKRWPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASSLDNLAADN--EKVQQILLDLF-PIFSEGL--PEILEQSVEEVIRGGFATVPNTAAFVGGIVAQEAIKLVTNQ-------------------------------------------------------------------YSPLDNTVVLNLI---------KSESSKFKF---------------|
19115288 Schizosaccharomyces_pombe_972h_ MQKYDRQVRLW---KAEGQNAIEKSHVCLLYANTVGCEALKNLILPGI----------GSFAVVD-DTSVDFSMDGMNFFIQYDQ---EGKSRA-RCTASLLQQLNPN--VEMEYLEMSPE-------------------------ALIDKNIEYFSK-----------------FSVVLSSNL---KEKPLFRLEEYLRSH-------------------------------KIPLLHFNSVGFAGILRISTHEYTTTQSQPELP-QDLRLKNPWPELINYVKSMDLDNMDS-SSLSEIPYIVLIIHVLLKVSPA---HAQNSQEADDCAMFRKIMEEYKG------KCDSENIEEASSNSWKAFKEYKLPSNVYEVLHDTRCVKIQEDSESFWIMAHCLKMF--YDETEFLPLSGLLPDMNCSTQQYVKLQVIYKEKSENDILKFKKYVQQTLKRLNRSVEEITDLEIKHFSRNCLNIKVMDFKTMKEEYQPTSNSA-----------------------------------------------------------------------FRIYDTILEK-HGKNYKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFSDTT--KTISVAQSFLS-QIGLEKF--FDVVYTAIQELERADGHELHSISSFIGGIVAQETIKLLAQQ-------------------------------------------------------------------YLPLNNTFVFDGV---------HSRTETFKL---------------|
21450341 Mus_musculus EQKYDRQLRLW---GDHGQEALESAHVCLINATATGTEILKNLVLPGI----------GSFTIID-GNLVSGEDAGNNFFLQKSS---IGKNRA-QAAMEFLQELNSD--VSGSFVEESPE-------------------------NLLDNDPSFFCR-----------------FTIVVATQL---LESTLLRLADVLWNS-------------------------------QIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHLQSYDLDHMEK-KDHSHTPWIVIIAKYLAQWYNE--TNGRIPKSYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPTFWILARALKEFVAKEGQGNLPVRGTIPDMIADSNKYIKLQNVYREKAKKDAAAVGNHVAKLLQSVGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTVNKDE--------------------------------------------------------IISSMDNPDNE--IVLYLMLRAV-DRFHKQHGRYPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSNYQVEEDIG--KLKSCLTGFLQ-EYGLS----VMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQ-------------------------------------------------------------------FVIFNNTYIYSGM---------SQTSATFQL---------------/
FINAL ---HHHHHHHH---HHHHHHHHH---EEEEE---HHHHHHHHHHHHH------------EEEEEE---EEE------EEEE-----------HH-HHHHHHHHH-------EEEEE------------------------------------HHHHHH--------------------EEE------HHHHHHHHHHHHHH-----------------------------------EEE--------EEEEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE-----------------------------------------------------------------------------EEEE------HHHHHHHHH-HHHHH------HHHHH-----H-HHHHHHH----------------HHHHHHHHHHHHH-------HHHHHHHHHH-----HHHHHHHHHHHHHHH--------------------------------HHHHHHHHHHHHHHHHH------------HHHHHHHHH------------EEEE------E----------HHHHHHHHHHHHHH--------------EEEE-------HHHHHHHHHHHH-HHH----------HHHHHHHH--EEEEEHHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------HHHHHHHHHHHHHH--------HH-----------------EE---\UBA1-C
23510338 Homo_sapiens QNRYDGQVAVF---GSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGE-----GGEIIVTD-MDTIEKSNLNRQFLFRPWD---VTKLKS-DTAAAAVRQMNPH--IRVTSHQNRVGPD-----------------------TERIYDDDFFQN-----------------LDGVANALD---NVDARMYMDRRCVYY-------------------------------RKPLLESGTLGTKGNVQVVIPF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTESYSSSQ--DPPE-------------------------------------------------------------KSIPICTLKNFPNAIEHTLQWAR-DEFEGLFKQPAENVNQYLTDPK-FVERTLRL------------AGTQPLEVLEAVQRSLVLQRPQTWADCVTWACH-----HWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTGSQ-----DRAAVATFLQSVQVPEFTPKSGVKIH------VSDQELQ-SANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLR-AENYDI---PSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQL----------------------------------------------------------------DSYKNGFLNLALPF--------FGFSEPLAAPRHQYYNQEWTL-WD|
6678483 Mus_musculus QNRYDGQVAVF---GSDFQEKLSKQKYFLVGAGAIGCELLKNFAMIGLGCGE-----GGEVVVTD-MDTIEKSNLNRQFLFRPWD---VTKLKS-DTAAAAVRQMNPY--IQVTSHQNRVGPD-----------------------TERIYDDDFFQN-----------------LDGVANALD---NIDARMYMDRRCVYY-------------------------------RKPLLESGTLGTKGNVQVVIPF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTESYSSSQ--DPPE-------------------------------------------------------------KSIPICTLKNFPNAIEHTLQWAR-DEFEGLFKQPAENVNQYLTDSK-FVERTLRL------------AGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACH-----HWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQ-----DRAAVASLLQSVQVPEFTPKSGVKIH------VSDQELQ-SANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLR-AENYDI---SPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQQL----------------------------------------------------------------DSYKNGFLNLALPF--------FGFSEPLAAPRHQYYNQEWTL-WD|
63054800 Schizosaccharomyces_pombe_972h_ GCRYDGQIAVF---GSEFQEKIASLSTFLVGAGAIGCEMLKNWAMMGVATGE-----SGHISVTD-MDSIEKSNLNRQFLFRPRD---VGKLKS-ECASTAVSIMNPSLTGKITSYQERVGPE-----------------------SEGIFGDEFFEK-----------------LSLVTNALD---NVEARMYVDRRCVFF-------------------------------EKPLLESGTLGTKGNTQVVVPH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTESYGSSQ--DPPE-------------------------------------------------------------KSFPICTLKNFPNRIEHTIAWAR-DLFEGLFKQPIDNVNMYLSSPN-FLETSLK-------------TSSNPREVLENIRDYLVTEKPLSFEECIMWARL-----QFDKFFNNNIQQLLFNFPKDSVTSTGQPFWSGPKRAPTPLSFDIHNREHFDFIVAAASLYAFNYGLKSET-----DPAIYERVLAGYNPPPFAPKSGIKIQ------VNENEEAPETAANKDKQELKSIADSLPPPSSLVGFRLTPAEFEKDDDSNHHIDFITAASNLR-AMNYDI---TPADRFKTKFVAGKIVPAMCTSTAVVSGLVCLELVKLVDGKKKI----------------------------------------------------------------EEYKNGFFNLAIGL--------FTFSDPIASPKMKVNGKEIDKIWD|
86565431 Caenorhabditis_elegans QSRYDGQAAVF---GWPYQECLFRQRWFVVGAGAIGCELLKNLSMMGVACGE-----GGLIKITD-MDQIEISNLNRQFLFRRRD---VGGKKS-ECAARAVTAFNSD--VRIEALAERVGLE-----------------------TEHIFNDEFFGE-----------------LNGVANALD---NVDARRYMDRRCVYY-------------------------------RLPLLESGTMGTKGNTQVVYPY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTESYSSSV--DPPE-------------------------------------------------------------KEIPVCTLKNFPNEIQHTIQWAR-EQFETFFAQPGEMANKFLSDERGFNEHVDKL------------ISGQQIDILQKVKDALIDARPSSAEDCIRWARN-----QFQELYHNNIAQMLHSFPPDQLTDSGAKFWSGAKRCPHVLNFDPSKEEHFNFVFAASILIAELYGVQPIL-----DREEVIRVALSVNPEPFEPKSGVKIAVTDAEAKEQNERGASSMIVDDDAAIEALKLKLATLNVKSTSKLNCVDFEKDDDSNHHMEFITAASNLR-AENYDI---LPADRMRTKQIAGKIIPAIATTTAAVAGLVCIELYKVVDANGIPKTPM------------------------------------------------------------ERFKNTFLNLSMPF--------FSSAEPIGAPKKTYMDREFTL-WD|
66826621 Dictyostelium_discoideum_AX4 GSRYDGQIITF---GKTLQNKIENLNYFLVGAGAIGCEMLKNFAMMGLGAGP-----KGLVHVTD-MDTIEKSNLNRQFLFRSSD---IQQLKS-QTAANAVRVMNPD--LNVKAYSLRVGPD-----------------------TESHYNEEFFNS-----------------LDGVCNALD---NVEARLYMDSQCVYY-------------------------------GKPLLESGTLGTKGNTQVVVPH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTESYSSSR--DPPE-------------------------------------------------------------KGIPVCTLHNFPNAIEHTIQWAR-DTFEGLFKNNADNVNSYLTNPA-YVQSLKTQ------------NPFVRLETLASIKASL-MDRPLDFNQCIAWARL-----KFEEYFNNNIEQLLYNFPKDMVTTTGTPFWSGPKRAPTPLKFDVENPLHLEFIVAAANLRAFNYGIKAET-----NIEVIQKQAANVIVPDFTPKK-VKIQTSE-NEPAPSSNTQQAGGDAEDDQCDTILSQLPQPSEMAGYKINSIQFEKDDDTNHHIDFITATSNLR-ATNYAI---SPADKHKTKGIAGKIIPALVTTTAVVAGFVCIELIKVIQNKAL-----------------------------------------------------------------EKYKSTFMNLGIPF--------FGFVEPIAAPKNKIREGWTWTLWD|
54636758 Drosophila_pseudoobscura GSRYDAQIAIF---GRKFQEQLADAKWFIVGAGAIGCELLKNFGMLGLGVGK------GQIFVTD-MDLIEKSNLNRQFLFRPHD---VQKPKA-LTAAAAIKRMNPD--VKVTAYELRVGAE-----------------------TEKVFSESFFGK-----------------LHGVANALD---NVDARIYMDRKCIFN-------------------------------RIPLVETGTLGTMGNVQVIVPF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATESYSSSQ--DPPE-------------------------------------------------------------KSIPICTLKNFPNAIEHTLQWAR-DAFEGVFKQSAENAAQYIADPQ-FTERIIKL------------PGIQPLEILDSIKKALIDDKPKSFADCVEWARL-----YWEDQYANQIKQLLFNFPPDQVTSSGQPFWSGPKRCPDPLVFDVNDSMHLDFIYAAANLRAEVYGLDQVR-----DRQAIAELVKKVHVPVFVPRSGVKIETNE--AAAAASANHYDDNEVDQDRVDKIITDLLKKAEKQS-KITPLEFEKDDDNNLHMDFIVACSNLR-ASNYKI---PPADRHKSKLIAGKIIPAIATTTSVLSGLAVLEVIKLIGGHSDL----------------------------------------------------------------PSFKNAFVNLALPF--------MAFSEPLPAAKLSYYGNEWTL-WD|
71024211 Ustilago_maydis_521 NSRYDGQIAVF---GQAFQHKIANARQFLVGSGAIGCEMLKNWSMMGLGSGP-----EGIIHVTD-MDTIEKSNLNRQFLFRSKD---VGHFKA-DTAAAAVAEMNPDLKGKIHSHQNRVGPE-----------------------TEDVYGDEFFAS-----------------LTGVTNALD---NVQARQYMDRRCVYY-------------------------------EKPLLESGTLGTKANTQVVVPH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTESYSSSQ--DPPE-------------------------------------------------------------KSIPVCTLKNFPNAIEHTIQWAR-EQFDEYFLKPAENVNQYLSQPD-YIETTLK-------------SGSGAKEQLDQIKQYLVDERPKSFEQCIYWARL-----RFEENYSNNIRQLLHSLPADAVTSSGQPFWSGPKRAPKPLTFDANDPTHLEYVMSAALLHAENYGLKGEA-----DAALFRKVLSSMQVPEFVPKDNVKIQV-----NENEAATTNNNSNADGDDLTEITSSLPEASSLAGVRLQPIEMEKDDDTNHHMDFITAASNLR-ASNYGI---SPADKHQTKGIAGKIIPAIATTTALATGLVNLELYKLLDEKKSL----------------------------------------------------------------EAYSNAFVNLALPF--------IAFSDPIAAQKLKYNDTEWTL-WS|
6322639 Saccharomyces_cerevisiae NSRYDNQIAVF---GLDFQKKIANSKVFLVGSGAIGCEMLKNWALLGLGSGS-----DGYIVVTD-NDSIEKSNLNRQFLFRPKD---VGKNKS-EVAAEAVCAMNPDLKGKINAKIDKVGPE-----------------------TEEIFNDSFWES-----------------LDFVTNALD---NVDARTYVDRRCVFY-------------------------------RKPLLESGTLGTKGNTQVIIPR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTESYSSSR--DPPE-------------------------------------------------------------KSIPLCTLRSFPNKIDHTIAWAK-SLFQGYFTDSAENVNMYLTQPN-FVEQTLK-------------QSGDVKGVLESISDSL-SSKPHNFEDCIKWARL-----EFEKKFNHDIKQLLFNFPKDAKTSNGEPFWSGAKRAPTPLEFDIYNNDHFHFVVAGASLRAYNYGIKSDDSNSKPNVDEYKSVIDHMIIPEFTPNANLKIQ------VNDDDPDPNANAANGSDEIDQLVSSLPDPSTLAGFKLEPVDFEKDDDTNHHIEFITACSNCR-AQNYFI---ETADRQKTKFIAGRIIPAIATTTSLVTGLVNLELYKLIDNKTDI----------------------------------------------------------------EQYKNGFVNLALPF--------FGFSEPIASPKGEYNNKKYDKIWD|
71411317 Trypanosoma_cruzi_strain_CL_Brener GSRYDKQIAVL---GAAFQSYLSKQRAFIIGAGALGCELIKNAACMGF----------GGISITD-MDSIEISNLSRQFLFRNSH---IGQHKS-RVAGEAAMAINHD--LHVTSFVEKVSVE-----------------------TEGIFNEAFWDS-----------------HAVVLNALD---NVQSRKYVDSRCLFY-------------------------------KKPLFESGTLGTKCNVQCIIPY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTESYSSSH--DPPE-------------------------------------------------------------KAIPLCTLKNFPNAIEHTIQWAR-DNFHVLFTNTPEEVNSYLQDPTTFAANLER-------------DPATKTMALKAVRDAL-LRWPMDAADCVRIARR-----LYHEYFSDAFRQLLYNIPIDKRNENGELFWSGAKKPPTPQEFSPDSELSMSFVYHCAYLLACVYGLPPFTL----SRADVARVAGETSVPEFVPRQAVFAT------SEAEKEESVANLAAEIGLQ-----DLPPVSEFHGRRMVPEFFEKDDPTNHHVEYITACSNMR-AVAYNI---PPADVHHTKRIAGKIIPAMVTTTALVTGLVGLEVLKRLLMTQRQERSGMPANAVPTYEEIQKQL--------------------------------------------SIYRNAFVNIALPF--------IAFSDPIIASGATYPLPDGTSVRW|
6855414 Leishmania_major RSRYAGQEAVL---GHAFQEYLRQQKAFIVGAGALGCELIKNVALMGF----------GEVSITD-MDTIEMSNLSRQFLFRNHH---IGRPKS-VVAAEAAGHINAD--VKITAYEAKMGPE-----------------------TEAIFNEDFWVQ-----------------QAVILNALD---NVMSRKYVDSRCLFY-------------------------------QKPLLESGTLGTKCNMQPAIPF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTESYSSSY--DPPE-------------------------------------------------------------KGIPLCTLKNFPNAIEHTIQWAR-DLFHLLFVSVPADVNQYLNDPVAFANSLRN-------------DPAAADAALQNVNDAL-SRWPQNEQNCVRLARL-----LYQEHFNDGFRQLLHSIPLDKRNEDGQLFWGGAKKPPTPQEFDVNSEQDTEFVYHCACLFAKVYQLPAFSL----SKEETARLAAAVTVPDFVPRHAVFAT------SESQTSQQTSSSRGLTVE------QLPPVAHFGSRRMRAEEFDKDDITNHHVQFITYCSNLR-ARAYSI---PVADFNQTKRIAGNIIPAMVTTTSLVTGLVGFEMLKYLLIQFHHARKPAVNGTGSSHGNFYLDADEEPEKLV------------------------------------TLFRSAFVNIALPF--------IAFSDPIIAPSHSYALPSGKKLRW|
84994606 Theileria_annulata_strain_Ankara DERYFDQVSLW---GSDLQNKLQNSKIFIVGAGALGCEFLKNFALLGCGSQQ-----EGLLTITD-NDRIEVSNISRQFLFRTRH---VGLSKS-SVACESALEINPS--IKVKPLEIRVGEE-----------------------TEDIFDEHFWSS-----------------LNVVVNALD---NIQARQYVDGICVWY-------------------------------EKPLVESGTLGTLGNVQVVVPH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTQSYSESQ--DPPE-------------------------------------------------------------TSIPLCTLKHFPYQVEHTIEWAR-DVFEGLFTQIPLDIKKIRQNDEVNSSNIDVG------------VTEIPYERLELISKLLNCTPKNAKEQLLRISSE-----LYNLHFVNNIQQLLNSFPKDHVLSDGQKFWSPPKRPPTPLTFDLSDKIVQLFILSTTKIFASMMNLDLD------VVESDILSLRGLRLPEFQPRV-LKLS------QDKLNVEVQSDTSADSNPL-------LNEITNSNRTLNAVEFEKDDESNYHIEFIWSASVLR-CRNYAI---KECNKMKAKLISGKIIPAIATTTAMIGGLVTIEFLKALCYRSLKI---------------------------------------------------------------SHFRNAFACLATPI--------WLQSEPLPPIPTKDKDYDPVTCGP|
123482348 Trichomonas_vaginalis_G3 NDRFDTYRKIF---GNSLQDKMMNLKYFMIGAGALGCEILKNWAMMGVFSGQ-----NGHLTITD-MDTIELSNLSRQLLFRDRD---IGHLKS-LTAAEAVKQMSPK--MKITAQSNKLTEE-----------------------TRNIYNDEFYES-----------------LDGVCNALD---NVKTRQYSDDLCVYY-------------------------------NKPLLESGTLGSKANAQIIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTQSYTDTA--DAEE-------------------------------------------------------------KSIPQCTLHNFPSEINHCCEWAR-DIFGGWMEHNPETINKFIKDPKKFIEEQKLI------------GLEELENNLQKVTK-LIKNRPKNFKQCLEKGLK-----KYQELFVWRINKILKDFPVDSLDENGQPFWRGSKRAPSPLSFNIESENDYLFVTSFAKIFARINSVEIPK-----TEAEIKEILKTIPVPEKRVKCCFEGS------IPLDDLINLSERYAKEQNM-----------------VKPESFEKDDDSNSHIDFISAAANLR-ATNYRI---KNESKLEIKRIAGKIIPAIATTTAMICGFVCLEMYKVHSRENRKI---------------------------------------------------------------EDFRSMFINLSTNH--------YAGAFPADATKSKLPNGMEITKWN|
67463386 Entamoeba_histolytica_HM_1IMSS NGRYSGQIDII---GKTVQQKIEDLSIFLVGSGAIGCEVLKTWAMMGLSSGK------GLIHITD-NDNIEKSNLSRQFLFRNNN---INQSKS-KVASEAVKIMNPE--IHIKDYQLRVGEA-----------------------TENIFTKNFFKS-----------------LSAVTTALD---NVQARMYCDAQCVKY-------------------------------GLAMIEGGTTGTKGNTQSIIPH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITQSYSTGSVRDPEE-------------------------------------------------------------KSIPMCTLHNFPNEIDHTIQWAR-DRFEGFFKTEIEPVKNYKEQGESYLESLKKE------------SPLVLLENLKLIVENGVSKVPHSFKDCIAWARE-----KYDINFVNTIQKLITNFPENTITDEGIPFWHAPKRFPHIYPFNIDNQYAKEFIISASLLRAEIYGIKNEL-----SKEEIIKYAYSLK----------EYT------SEEKKTEEPEAEIKQLSEE---------IKGKEIPKVNPIEFEKDDDNNHHIEFITACSNLR-AENYCI---KPADFLKTKLIAGKIIPAMITTTAVVSGLQCIELLKVIEKKPL-----------------------------------------------------------------EAYHCSFLNLAIGY--------MDATEPEAVKKTKICDGLEVSIWD/
1y8qD.pdb (UBA2) HHHHHHHHHHHEEEEEE-HHHHHHHHHHHHHHH-----------EEEEEEE--------------------------HHH-HHHHHHHH-------EEEEEEE----------------------------------HHHHHH--------------------EEEEE-----HHHHHHHHHHHHHHH-------------------------------H-EEEEEEEE--EEEEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH---HHHHHHHHHH-HHHHHHH---------------------------------------hhhhhhhhhhhhhhhhhhh-HHHHHHHHH--HHHHHHHHHHHHHHHHH---------------------------HHHHHH-----------------------------------------hhhhhhhhh------------------HHHHHHHHHHHHHHHHHHHH----HHHH----------HHHH--HHHHHHHHHHH-HHHH--------HHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------EEEEEEE---------------EEEEEEE-------------\UBA2/SAE2
1y8qD ----MALSRGL---PRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGF----------SHIDLID-LDTIDVSNLNRQFLFQKKH---VGRSKA-QVAKESVLQFYPKA-NIVAYHDSI---------------------------MNPDYNVEFFRQ-----------------FILVMNALD---NRAARNHVNRMCLAA-------------------------------DVPLIESGTAGYLGQVTTIKKG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTECYECHPKPTQ---------------------------------------------------------------RTFPGCTIRNTPSEPIHCIVWAK-YLFNQLFGEEDADQEVSPDRADPEA------------------AWE-------------------ISTKEWAKSTGYDPVKLFTKLFKDDIRYLL----------TMDKLWR-KRKPPVPLDWAEVQ---------------------------------------------------SQLG------LKDQQVLDVKSYARLFSKSIETLRVHL----AEKGDGAELIWDKDDPSA--MDFVTSAANLR-MHIFSM---NMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGK--------------------------------------------------------------------IDQCRTIFLNKQPN-------PRKKLLVPCALDPPNPNCYVCASK|
123471449 Trichomonas_vaginalis_G3 ------------------MDFDKSPNILLVGAGGIGCEIIKSLAIDGV----------YRITVVD-FDTISLSNLSRQFFYSEDD---IGKEKS-IRLAENAMKRYPNL-QITGISGNV---------------------------LDSSFDPDFIDQ-----------------FDFVFCGVD---NIDARMRISQLCVIT-------------------------------QTPFIDCASSGKHAQSVPTIPF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSACYVCSPVAAPS--------------------------------------------------------------GPKVTCTIRSTPQTIEHCSAWSF-HLFNAVFSGQGSNDVISVD------------------------NLEPQA--------------------------------LYDNVFVKRIEELR----------SKTEIWK-HRVPPDPYPAK-VTPN---------------------------------------HEPI----------------TRPCDKWTLEESCGVFADVVSRL-------------SPPLVFDKDDDDH--LAFATAATNLQ-SHCFHI--NKAVSMFENKGLVAVVVPALATTNSIISGIAVQQM-KQMFTE-------------------------------------------------------------------NKLNVKSVWMSNSLN---------GPKLTPVKLEPPSKTCSICGYE|
6320598 Saccharomyces_cerevisiae MPRETSLVTII---GEDSYKKLRSSRCLLVGAGGIGSELLKDIILMEF----------GEIHIVD-LDTIDLSNLNRQFLFRQKD---IKQPKS-TTAVKAVQHFNNS--KLVPYQGNVM--------------------------DISTFPLHWFEQ-----------------FDIIFNALD---NLAARRYVNKISQFL-------------------------------SLPLIESGTAGFDGYMQPIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTECFECTKKETP---------------------------------------------------------------KTFPVCTIRSTPSQPIHCIVWAKNFLFNQLFASETSGNEDDNNQ-----------------------DWGTDDAEEIKRIKQETNELYELQKIIISRDASRIPE-ILNKLFIQDINKLL----------AIENLWK-TRTKPVPLSDSQINTP---------------------------------------TKTAQ---------------SASNSVGTIQEQISNFINITQKLMDRY------PKEQNHIEFDKDDADT--LEFVATAANIR-SHIFNI---PMKSVFDIKQIAGNIIPAIATTNAIVAGASSLISLRVLNLLKYAPTT-------------------------------------------------------------KYTDLNMAFTAKASN------LSQNRYLSNPKLAPPNKNCPVCSKV|
56473309 Entamoeba_histolytica_HM_1IMSS --------------MSLSKEEIEKKRILVVGAGGIGCEVLKNILLIGF----------KHLEVID-LDVIDLSNLNRQFLFNKNH---IGQPKS-VIAAQVSKERYGPE-AEIIAHHCEI--------------------------QNNKFNIDYYKT-----------------FDIVINALD---NLNARKHVNRMCVCA-------------------------------NVPLIDGGTSGFIGQTTPIIPK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETECYECQPKVPP---------------------------------------------------------------KGYAVCTIRSNPSTAVHCVFWSK-QLIQKLFGNADDGNYLN--------------------------DFQFASTATRWKE-------------------------VYDKVFTLDIKVLH----------QSEELWK-LRKKPNIWTYEEIINC-----------------------------------------------------------SDTSPLKEVKPFVKLYYKSFNILQKRY-------ENKGPFEFEKDDDDM--IDFITACTNIR-CAIFNL---QRISRFEVQEKAGNIIPAIPTTNSIISGLMIIEMMKVLSQ--------------------------------------------------------------------NKTNLRICYLAKKPL--------KNHLLTFEKTSQPNKQCYICGNE|
58268664 Cryptococcus_neoformans_var_neoform MPRSTYTEALL---GPEVYKKVRETKVLVVGAGGIGCELLKNLVLVGF----------ANIEIID-LDTIDLSNLNRQFLFRKPD---ISKSKA-LVAAATAHHFNPNS-GININARHGNV-------------------------KDSVNDLEWIKG-----------------FGLVMNALD---NMDARRHVNRLCQAA-------------------------------GVPLIESGTAGYLGQVTPMIKD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTECFDCVPKPAP---------------------------------------------------------------KAFPVCTIRSTPSEPIHCIVWAKTYLFGKLFGEDDEDMDTEELDKA---------------------KSSGENAEEIENLKKEAAAFRQVRKSLSEEDGPRR---VFHKIFNEDIRRLL----------AMEDMWKKEGRVKPVPLDCDAILDETFVTPPLRTVPVTNQQADS-------------------DRAAERDKGKSAAL------LKDQKELNLKENLELFLDSCKRLSARA-----LAFPDTPLSFDKDDDDT--LDFVLATANLR-ATAYGI---PNKTRFQVKEMAGNIIPAIATTNAIIAGLIVMQSLNILSRIHSTSNGGPSTDS-------------------------------------------------------SSIPVRNVFLRTDPT----------KPLGSFLPQHPDPTCSVCRDV|
19112737 Schizosaccharomyces_pombe_972h_ MQLSNDMKPLT---FVEALRNFKSAKVLLVGAGGIGCELLKNLLMSGV----------KEVHIID-LDTIDLSNLNRQFLFRKKH---VKQPKA-IVAAKTASSFNPNV-KLEAYHANI---------------------------KEDRFNVAWFRQ-----------------FDLVFNALD---NLDARRHVNKQCLLA-------------------------------SVPLIESGTTGFLGQVQVIIHG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTECYDCNPKEPP---------------------------------------------------------------KTYPVCTIRSTPSQPIHCVVWAKSYFFPQLFSNDQESDGIIDNV-----------------------SANEMERREIAELARETTELNELRSSIGQSDNGFEK--IFTKMFTKDIVRLR----------EVPDAWT-YRSPPKELSYSELLEN---------------------------------------AEKA------TSPW------LNEQNVWNVAESFAVLRDSIRRLALRS-----KSSKDD-LSFDKDDKDT--LDFVAAAANLR-AHVFGI---QQLSEFDIKQMAGNIIPAIATTNAVIAGLCITQAIKVLQGD--------------------------------------------------------------------LNDLKNIYLAKRPT----------RVLHCEKTCKPNPYCPTCSFV|
42570865 Arabidopsis_thaliana ---------MA---TQQQQSAIKGAKVLMVGAGGIGCELLKTLALSGF----------EDIHIID-MDTIEVSNLNRQFLFRRSH---VGQSKA-KVARDAVLRFRPNI-NIRSYHANV---------------------------KNPEFDVDFFKQ-----------------FDVVLNGLD---NLDARRHVNRLCLAA-------------------------------DVPLVESGTTGFLGQVTVHIKG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTECYECQTKPAP---------------------------------------------------------------KTYPVCTITSTPTKFVHCIVWAKDLLFAKLFGDKNQDNDLNVRSNN---------------------SASSSKETEDVFERSEDEDIEQYGRK------------IYDHVFGSNIEAAL----------SNEETWK-NRRRPRPIYSKDVLPESLTQQNGSTQNCSVT------------------------DGDLMVSAMPSLGL------KNPQELWGLTQNSLVFIEALKLFFAKR------KKEIGHLTFDKDDQLA--VEFVTAAANIR-AESFGI---PLHSLFEAKGIAGNIVHAVATTNAIIAGLIVIEAIKVLKKD--------------------------------------------------------------------VDKFRMTYCLEHPS--------KKLLLMPIEPYEPNPACYVCSET|
66807481 Dictyostelium_discoideum_AX4 SERYSHIIQAL---GQSTFDKIQTCKILVVGAGGIGCELLKNLVLTGF----------KNIDIID-LDTIDISNLNRQFLFRKQH---IGMSKA-KIAKESVMKYNEQV-NITAHHGDV---------------------------KSSEFGSEFFKQ-----------------FDLVMNALD---NISARRHVNRLCLSV-------------------------------DVPMIESGTAGYLGQVSVIRKG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTECFECQPIAVP---------------------------------------------------------------KQFAVCTIRTNPSAPIHCIVWAK-MLFGKLFGPKDDDGGGDS-------------------------SSLTDLDNNIIHGTEELGNIKRDEQLLIEKEKGFKRW-VFHKIFHTDIETLI----------HMPDLWK-DKQPPTSLKLDEILSSKE-------------------------------------VSQAEEEGDQLIFK------LPDQKQWTFKENVEVFLDCLEKLKQQF-----DQSNSKPMTWDKDDELA--LSFVCSASNIR-SKIFGI---PMKSRFDVKSMAGNIIPAIATTNAVIGGLIVMEAIKVVDGR--------------------------------------------------------------------FDQCLSTYLYQLPS--------GKRLLMPTQLEPQNPKCFVCNRS|
24660640 Drosophila_melanogaster --MAAAINGVF---PPTLQELVKKSKVLVVGAGGIGCEVLKNLVLSGF----------TDIEIID-LDTIDLSNLNRQFLFHREH---VGKSKA-RVARESALSFNPDA-KITAYHDSV---------------------------TSTDYGVNFFKK-----------------FDLVLSALD---NRAARNHVNRMCLNA-------------------------------DVPLIESGTAGYNGQVELIKRG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTQCYECTPKDKQ---------------------------------------------------------------RSFPGCTIRNTPSEPIHCIVWAK-HLFNQLFGESLEDEDISPDAADPDAKEKDGGDGNGEPKGDGKEKGEESKEEKEAKEDTANGNIMRINTRQWAKDCNYDAGKLFNKFFNEDITYLL----------RMSNLWK-TRKAPVPVQWDTLLPE---------------------------------------GSSGD----QKDVA------KQHHKVWSIEECAQVFANSLKELSANF----LKLEGDDTLAWDKDDQPA--MDFVAACANVR-SHIFDI---ERKSRFEIKSMAGNIIPAIATTNAITAGISVMRAFKVLEAK--------------------------------------------------------------------WEQCKAVYARLRPN------ARNHFLVPDASLPGPNPNCHVCASD|
82595829 Plasmodium_yoelii_yoelii_str_17XNL --MHKTIRKIF---DTKICERLESMHILLVGAGGIGSEFLKSIITIGC----------KNIDIID-IDTIDITNLNRQFLFKKKD---VKKHKS-IVARERALKHRKDL-NINAYTFD-----------------------------VCTMKGSDISK-----------------YDYVINALD---NIKARKYVNKLCITE-------------------------------KKVLIEAGSTGYNGQVYPIFSN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETKCYNCEEKPKN---------------------------------------------------------------KTYAICTIRQTPSLPEHCVAWGK-LIFETFFCKNDNETLI---------------------------DIKKHIEEESKKRNMDKEEIIRF---------------IFNYLFHDTINELI----------SLKKDYT-IMPKPILFEENSKQEPHNIEKLNQEMPNNLKTTDNKIADKIA-------------GKIAGKIAENNSIQ------LSSQNIWDKEKCIEMYVSTFNKLYKYLN---IKKTTEEYLIFDKDDDDC--INFITCLSNLR-MINFSI---KQKSKFDIQSIAGNIIPAISSTNAIVAAFQAAQLVHVIEHFELLKEKETEQNGDNKKEINL-----------------------------------------------RDSKAKHIWIKNVVNGNKI--FSRGNIVNAENLETPNPNCYVCQQP|
84999730 Theileria_annulata_strain_Ankara ----------M---LDEYYEYLNNASILLVGAGGIGCEVIKNLMLNGV----------KKLTIVD-MDTIDVSNLNRQFLYLPEH---VNKYKA-EVARMRALEINPKS-EVKSLVCD-----------------------------VNSWEPNDLLQ-----------------YDVVLNALD---NIKARSHINYCCIQS-------------------------------GVPLIESGSTGYNGQVYPIVKD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTKCYECDPLPKT---------------------------------------------------------------SSIPVCSIRQIPEKPTHCIAWAR-MLYQLLFGTPDNNNLLTDL------------------------SVPTLPDLNNLDEPVVVDYLNR----------------IFDFLFNSEVKSLL----------KMEEVWI-NRDPPKPLEHQFTLKRKANQIEKTSED----------------------------ETLKDLEKEPPNSK------RNKFVVLELEELYEQFSTSVKEILLNN----SDM--VGSLIFSKNDEVC--VDFVSSAANLR-MINFGI---KPLSTWDVQSIAGSIVPAIASTNAIVASFQVVQLLHLLKFLKSNDKS-------------------------------------------------------------LDTYCRKVWIKSSVMGSNP--LVKGKLSQPELLEPPNPKCTTCQQK|
74198899 Mus_musculus ----MALSRGL---PRELAEAVSGGRVLVVGAGGIGCELLKNLVLTGF----------SHIDLID-LDTIDVSNLNRQFLFQKKH---VGRSKA-QVAKESVLQFHPQA-NIEAHHDSI---------------------------MNPDYNVEFFRQ-----------------FILVMNALD---NRAARNHVNRMCLAA-------------------------------DVPLIESGTAGYLGQVTTIKKG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTECYECHPKPTQ---------------------------------------------------------------RTFPGCTIRNTPSEPIHCIVWAK-YLFNQLFGEEDADQEVSPDRADPEA------------------AWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLL----------TMDKLWR-KRKPPVPLDWAEVQSQ---------------------------------------GEANADQQNEPQLG------LKDQQVLDVKSYASLFSKSIETLRVHL----AEKGDGAELIWDKDDPPA--MDFVTSAANLR-MHIFSM---NMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGK--------------------------------------------------------------------IDQCRTIFLNKQPN-------PRKKLLVPCALDPPNTNCYVCASK/
1tt5D.pdb (UBA3) HHHHHHHHH--EEEEEE-HHHHHHHHHHHHHH------------EEEEEEE--------------------------HHH-HHHHHHHHHHH-----EEEEE-----------------------------------HHHHHH--------------------EEEEE-----HHHHHHHHHHHHHHHHEEE---EEE-----------------------EEEEEEEE-EEEEEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH---HHHHHHHHHH-HHHHHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH--HHHHHHHHHHH-HH----------HHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------EEEEEEE------------EEEEE-----------------\UBA3(NEDD8)
1tt5D GPFTHPDFEPS---TESLQFLLDTCKVLVIGAGGLGCELLKNLALSGF----------RQIHVID-MDTIDVSNLNRQFLFRPKD---IGRPKA-EVAAEFLNDRVPN--CNVVPHFN----------------------------KIQDFNDTFYRQ-----------------FHIIVCGLD---SIIARRWINGMLISLLNYED-GVLDPSS------------------IVPLIDGGTEGFKGNARVILPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTACIECTLELYPPQ-------------------------------------------------------------VNFPMCTIASMPRLPEHCIEYVR-MLQWPKEQPFGE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPLDGDDPEH--IQWIFQKSLER-ASQYNI---RGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSA-------------------------------------------------------------------YIPLNNYLVFNDVD--------GLYTYTFEAE---RKENCPACSQL|
118351055 Tetrahymena_thermophila_SB210 TQFKGDLFEPS---DELLEMYLESAKVLVVGAGGLGCEILKDLALSGV----------KDIHVID-LDTIDLTNLNRQFLFRMKD---VGKFKS-QVAADFIMRRVPG--CKVTAHIG----------------------------KIQEKDDEFYRQ-----------------FQVIIAGLD---NVEARRWLNSLVHGLCQFDEDQKVKIET------------------QIRLVDGGTEGFKGQARLIVPY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETACYECTLGTLPKQ-------------------------------------------------------------QSYNSCTLASTPRIPEHCIMYAY-LHEWDLAFP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRKADKDSMED--MTWIYETAKKR-AEQFNI---KGVDYNKTIGVVKNIIPAIASTNAIIAASCANEAFKAFLQQ-------------------------------------------------------------------SLNIKDYFQYMGNT--------GVSTLTFPYE---RNEKCIVCSSL|
58264602 Cryptococcus_neoformans_var_neoform GPWTDERFQGG---TETANFLRTKAKILVIGAGGLGCEILQNLALSGF----------NDIHVID-MDTIDISNLNRQFLFREAD---VGKSKA-LVAAEFVMKRVPG--CTVTPYHG----------------------------RIQDHPTSFYST-----------------FDVIVAGLD---SISARRWINATLVQMAQEDE------EN------------------IKPLVDGGTEGFKGQARVILPT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITSCYECSIDMLTPP-------------------------------------------------------------TAFPICTIANTPRLPEHCIEWAS-VLEWPKVFR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DKKLDTDDPEH--IEWLYKQAAAR-AGQFNI---EGVTWALTQGVVKNIIPAIASTNAIIAASCCNEAFKIATAS-------------------------------------------------------------------APYLNNYMMYVGNE--------SVYTYTFEHE---QRPDCPVCGGE|
66810357 Dictyostelium_discoideum_AX4 SPSFEPDTKAS---PNIMNGLQNDFKVLVIGAGGLGCEILKNLALSGF----------RNIDVID-MDTIDISNLNRQFLFRRKD---VGKSKA-EVAAAFINSRITG--CNVTPHKC----------------------------RIQDKDEDYYRQ-----------------FKIVIAGLD---SIEARRWINGLLVNLVVVNDSGDIEPDT------------------IIPLVDGGTEGFKGQARVILPK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISSCFECSLDAFPPQ-------------------------------------------------------------VSYAICTIANTPRVPEHCIQWAL-LFGLQDATLEKPFD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKQFDNDNPDH--MNWLFECAKKR-AEKFNI---NGVTYKLTQGVAKNIIPAIASTNAIIAAACCNEVFKFCTDS-------------------------------------------------------------------SGYLNNYMMYNGLN--------GVYTFTFEYE---IKEGCAVCGTN|
39593957 Caenorhabditis_briggsae DTAYKVPWFNP---GPKNFEAVQNVKVLVIGAGGLGCELLKNLALSGF----------RSIDVID-MDTIDVSNLNRQFLFREAD---VGKSKA-EVAAAFVEQRVSG--CHVTAHNC----------------------------RIEDKDPDFYRR-----------------FSMVICGLD---SIPARRWINGMLCDLVLEHADGTPDMST------------------IIPMIDGGTEGFKGNARVIYPK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSACIDCTIDLYPPQ-------------------------------------------------------------VNFPLCTIAHTPRLPEHCVEYIK-VVVWPEQKPFE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAALDADDPEH--VEWVLQGALLR-AEKYNI---RGVDRRLTSGVLKRIIPAVASTNAVIAASCALEALKLATNI-------------------------------------------------------------------AKPIDNYLNFTQIH--------GAYTSVVSMS---KDESCHVCNGG|
54636774 Drosophila_pseudoobscura GPFCKDDFTAS---PDNLDFLQTKSKVLIIGAGGLGCELLKDLALMGF----------GNLHVID-MDTIELSNLNRQFLFRRTD---IGSSKA-ECAARFINGRVPT--CRVTPHFK----------------------------KIQDFDDSFYQQ-----------------FHLIVCGLD---SIVARRWINGMLLSMLRYEDDGTIDVSS------------------IVPMIDGGTEGFKGNARVILPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTACIECTLDLFPPQ-------------------------------------------------------------VNYPLCTIANTPRLPEHCVEYVK-LIQWDKENPF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVPLDGDDPQH--IGWIYERAVER-ANEFNI---AGITYRLVQGVIKHIIPAVASTNAVIAAACAMEVFKLATSC-------------------------------------------------------------------YDSMSNYLNFNDLD--------GIYTYTYEPE---KSESCLACSNK|
71744478 Trypanosoma_brucei_TREU927 VQRAPPIFANG---YSSDSITWDSVRVLLVGAGGIGCEVLHSLALSGF----------ADITVID-MDTVELSNLSRQFLFREAD---IGRSKA-EVAAAAVECRCPG--VRVRALFG----------------------------RIEDQSDEFYRQ-----------------FHAVILAVD---SVAARRWVNQKVAEVAEWETFDMVDGGCYENIAARPIARRMRRIAYAMPLIDTGTEGYEGCCRVVLLR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVNPTPCIECDLSLYPSR-------------------------------------------------------------RTVPLCTLENIPRLPEHCVLYVK-FKLWEELRP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HESPDADNPEH--IAWMTVMAQRR-KEAFGI-EGPDIDDAFTLGVVKNVVPAVGFTNALVAAQAVLELVKLLTGV-------------------------------------------------------------------AFPVQCFSYYNGSTKC------GLTSYVTDLI---PNPTCSVCGPR|
123485574 Trichomonas_vaginalis_G3 RGPYCYDYFVT---GDEGKDYLEGRQVLVLGAGGLGCELLKCLAMSGI----------KHIHVVD-MDTIDVSNLNRQFLFRQKD---VGRYKS-EVAAEFIKRRVPD--CEITSHTC----------------------------KIQEFPDDFFLQ-----------------FDVIIGGLD---NVNARLYMNDKVVQIAKEG-------GP------------------VIPYIDGGSEKWMGHCKFIKPL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETACLSCYPSIMKTKP------------------------------------------------------------QQFQFCTIATNPRQPEHCVAWVK-DILWPKEHP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEKLDGDNDDH--IAYVVEKANEH-GKKYNL---GEITPRMARGVIKNIIPAIASTQAFVASMCTTEAIKYITGC--------------------------------------------------------------------APNSNNQQVVGDN--------GIAYANTVMQ---KNSKCEKCSDE|
67481229 Entamoeba_histolytica_HM_1IMSS SFLKRTGGTAE---EEGNIDYHD-FKILVVGAGGLGCEVLKALAMVGF----------QNLTIID-MDTIEYSNLNRQFLFRKKD---VGRPKS-EVAAEFVMKKVPG--CKITHVVG----------------------------RLEDQPLSFYKS-----------------FKLVISGLD---NLGARRWTSSTLCSLVETRN-GEIDPNT------------------IIPLIDGGTEGFQGHVMVIVPK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGPCLDCIISLFPPQ-------------------------------------------------------------KTFPMCTIASQPRLPEHCIVWAS-QIAWENPTINTEFPH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTKVDADNPAH--VQWVYEHALQR-AEEKNI---SGVTYRLTLGVIKNIMPAIASTNSLIAAQTANEAFKYATGC-------------------------------------------------------------------ANNLDNYLVYYGKD--------GINTSVESLE---KKKGCLVCDMQ|
38257360 Arabidopsis_thaliana GNLVDPGFVPG---PGLRDDIRDYVRILVIGAGGLGCELLKDLALSGF----------RNLEVID-MDRIEVTNLNRQFLFRIED---VGKPKA-EVAAKRVMERVSG--VEIVPHFS----------------------------RIEDKEIEFYND-----------------FNIIALGLD---SIEARKYINGVACGFLEYNEDDTPKRET------------------IKPMVDGGTEGFKGHAKVILPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTPCFECTIYLFPPQ-------------------------------------------------------------VKFPLCTLAETPRNAAHCIEYAH-LIQWETVHR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKTFDPDEPEH--MKWVYDEAIRR-AELFGI---PGVTYSLTQGVVKNIIPAIASTNAIISAACALETLKIVSAC-------------------------------------------------------------------SKTLVNYLTYNGGE--------GLYTEVTKFE---RDTECLVCGPG|
55670027 Homo_sapiens GPFTHPDFEPS---TESLQFLLDTCKVLVIGAGGLGCELLKNLALSGF----------RQIHVID-MDTIDVSNLNRQFLFRPKD---IGRPKA-EVAAEFLNDRVPN--CNVVPHFN----------------------------KIQDFNDTFYRQ-----------------FHIIVCGLD---SIIARRWINGMLISLLNYED-GVLDPSS------------------IVPLIDGGTEGFKGNARVILPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTACIECTLELYPPQ-------------------------------------------------------------VNFPMCTIASMPRLPEHCIEYVR-MLQWPKEQPFGE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPLDGDDPEH--IQWIFQKSLER-ASQYNI---RGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSA-------------------------------------------------------------------YIPLNNYLVFNDVD--------GLYTYTFEAE---RKENCPACSQL|
19113852 Schizosaccharomyces_pombe_972h_ PGPFNLDAPEN---PEETLKSAFSSKILIIGAGGLGCEILKDLALSGF----------RDLSVID-MDTIDITNLNRQFLFNESN---IDEPKA-NVAASMIMKRIPS--TVVTPFYG----------------------------KIQDKTIEFYKE-----------------FKLIICGLD---SVEARRWINSTLVAIAKTGD--------------------------LIPLVDGGSEGLKGQARVIIPT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITSCYECSLDMLTPK-------------------------------------------------------------ISYPICTLANTPRLPEHCVEWAY-LLEWPRVFLNASVDSFSKQEVFEPLDGK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSNFEPDNIRH--IDWLVKRSIER-ANKFQI-PSSSINRFFVQGIVKRIIPAVASTNAIIAASCCNEALKILTES-------------------------------------------------------------------NPFLDNYMMYVGED--------GAYTYTFNLE---KRSDCPVCGVL/
FINAL ----HHHHHHH----HHHHHHHH---EEEEEE----HHHHHHHHHH-------------EEEEEE---HHHHHHHHH-HHHH----------HH-HHHHHHHHH----E-EEEEEEEE-----------------------------HHHHH-HHHHHH----HH-----------EEEEE-------HHHHHHHHHHHHH---------------------------------EEEEEE--------EEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------------HHHHHHHHH-------HH-EEEE------------------\UBA5/UBE1DC1
13376212 Homo_sapiens SNPYSRLMALKRMGIVSDYEKIRTFAVAIVGVGGVGSVTAEMLTRCGI----------GKLLLFD-YDKVELANMNR-LFFQPHQ---AGLSKV-QAAEHTLRNINPDV-LFEVHNYNIT--------------------------TVENFQ-HFMDRI----SNGGLEEGKP--VDLVLSCVD---NFEARMTINTACNELGQ-----------------------------TWMESGVSENAVSGHIQLIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESACFACAPPLVVAANIDEKTL------------------------------------------------------KREGVCAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPTTMGVVAGILVQNVLKFLLNFG--------------------------------------------------------------------TVSFYLGYNAMQ-------DFFPTMSMK-----PNPQCDDRNCR|
15220493 Arabidopsis_thaliana SNPYSRLMALQRMGIVDNYERIREFSVAIVGIGGVGSVAAEMLTRCGI----------GRLLLYD-YDTVELANMNR-LFFRPDQ---VGMTKT-DAAVQTLAEINPDV-VLESFTMNIT--------------------------TVQGFE-TFTSSLTNKSFCPSKEGGSG--VDLVLSCVD---NYEARMAVNQACNELRQ-----------------------------TWMESGVSEDAVSGHIQLLVPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETACFACAPPLWNMGGFKDSVIQGIV--------------------------------------VASGIDERTL--KREGVCAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPTTMGVVAGLLVQNSLKFLLNFG--------------------------------------------------------------------EVSPYLGYNSLK-------DFFPTMKMR-----PNPQCSNVACL|
17508819 Caenorhabditis_elegans SNPYSRLMALQRMGIVNEYERIREKTVAVVGVGGVGSVVAEMLTRCGI----------GKLILFD-YDKVEIANMNR-LFYQPNQ---AGLSKV-EAARDTLIHVNPDV-QIEVHNFNIT--------------------------TMDNFD-TFVNRI----RKGSLTDGK---IDLVLSCVD---NFEARMAVNMACNEENQ-----------------------------IWMESGVSENAVSGHIQYIEPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTACFACVPPLVVASGIDERTL------------------------------------------------------KRDGVCAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPTTMAVVAGFLVMNTLKYLLNFG--------------------------------------------------------------------EVSQYVGYNALS-------DFFPRDSIK-----PNPYCDDSHCL|
66800527 Dictyostelium_discoideum_AX4 SNPYSRLMALKKMGIVNNYENIRNLSVIIVGLGGIGSVAAEMLTRCGI----------GKLLLFD-YDTVEIANMNR-LFFRPEQ---SGKSKT-MAAQETLSSINPDV-QFESHNYNIT--------------------------TIDNFE-HFKGRI----EKGGLVEGEP--VDLVLGCVD---NFEARTAINQACLELGK-----------------------------SWMESGVSENAISGHIQLIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESACFQCVPPLIVASGIDERTL------------------------------------------------------KREGVCAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPTTMGIVAGMLVQNTLKYLLKFG--------------------------------------------------------------------EVSSLLGYNALL-------DYFPKDNMK-----PNPECSNSFCI|
76363459 Mus_musculus SNPYSRLMALKRMGIVSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGI----------GKLLLFD-YDKVELANMNR-LFFQPYQ---AGLSKV-HAAEHTLRNINPDV-LFEVHNYNIT--------------------------TVEHFE-HFMNRI----SNGGLEEGQP--VDLVLSCVD---NFEARMAINTACNELGQ-----------------------------TWMESGVSENAVSGHIQLMIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESACFACAPPLVVASNIDEKTL------------------------------------------------------KREGVCAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPTTMGVVAGILVQNVLKFLLKFG--------------------------------------------------------------------TVSFYLGYNAMQ-------DFFPTMFMK-----PNPHCDDKNCR|
66357224 Cryptosporidium_parvum_Iowa_II DERYSRLTALENMGVVDDYSLIMKKTIFVIGVGGVGSVVVEMLTRCGV----------GKLIIVD-FDIVELSNMNR-MFYNMNH---IGMYKT-DACVDTLKLINPKI-NIEKYNINI----------------------------VEDYS-IFYNIF----------KTKK--IDLLVSCVD---NYSARSIISQVCNEFDL-----------------------------VWFESGISENAISGHIQFVIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTACYCCAPPLVNFESNFSEDKINSI--------------------------------------VMNSENENNSKKLSSRTCAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSTTTSVIAGILVNNILKYFLGFG--------------------------------------------------------------------ENSNFLGYHMID-------DYFPRYSII-----PNKECIDKWCR|
71407292 Trypanosoma_cruzi_strain_CL_Brener DNPYSRLMALQRMGVVDNYEAIRQKSVAIIGAGGVGSVVAEMLTRCGI----------SKILIFD-YDKVELANMNR-LFYRPEQ---KGMTKV-LAAKQTLEDINPDT-EIVPYAFSIT--------------------------STEHWQ-DFVDALT---KNGGVQPNSP--VDLLLCCVD---NFQARLTVNYACLLHNI-----------------------------PWMESGVAENAVSGHIQLLLPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTPCYECCPPLVVATGMPEA--------------------------------------------------------KREGVCAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPTTMGIVAGFMAQNTLKYLLNFG--------------------------------------------------------------------TVSEYVGYDAMR-------DHFPSITIK-----ANPECRNETCV|
68125462 Leishmania_major DNPYSRLMALQRMGVVDDYESIRDKAVAIIGAGGVGSVVAEMLTRCGI----------GKLLLFD-YDTVEMANMNR-LFYRPEQ---QGMKKV-EAAKETLEGINPDT-VIEPHAYNIT--------------------------STEHWQ-RFSEAL----TRGGVSPNSP--IDLLLCCVD---NFQARLTVNLACLTYEV-----------------------------PWMESGVAENAVSGHIQLLLPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTPCYECCPPLVVATGLPEA--------------------------------------------------------KREGVCAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPTTMGIVAGFLAQNTLKYLIQFG--------------------------------------------------------------------EVSEYIGYDAMR-------DHFPRVELK-----ANPECRNALCG|
118351953 Tetrahymena_thermophila_SB210 DNPYSRLMALKRMGVVQNYEKIRDCSVLVVGVGGVGSVLAEMLTRCGL----------GKLIIYD-YDKVELANMNR-LFYTPQQ---VGLSKV-DAAKGTLQSINPEI-TIEAYNMNIT--------------------------TNSGFE-HLLDRI----KKGG-KNGER--INLVVSCVD---NYAARMAINTGCNELDQ-----------------------------IWFESGVSEDAMSAHIQIMIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETACFACATPLAVVESNEHTI-------------------------------------------------------KREGVCAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPTTMGITAGFLAQNALKFLLDFG--------------------------------------------------------------------DLAFVLAYNAKA-------DFFTNYMIK-----PNSECKENECR/
FINAL ---HHHHHHHHH------HHHHH---EEEEE-----HHHHHHHHHH-------------EEEEEE---EEEE----EEEHHHH---------HH-HHHHHHHHHH-----EEEEEEEEE------------------------------------HHHHHH--HHHHHHHHHHH---EEEEE------HHHHHHHHHHHHH-----------------------------------EEEEEE-E--EEEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE-------------------------------------------------------------------------EEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH------------------------------------------------------------------------------EEEE--EE---HHHHEEEEEE----------------\Atg7/Apg7
19112876 Schizosaccharomyces_pombe_972h_ STLNLSLMRWRLV-PQLDLDRIQNSKCLLLGAGTLGCGVARNLLSWGV----------RHVTFVD-YSTVSYSNPVRQSLFTFED-CKRKLPKA-ECAAQRLKEIYPNM-FSTGYNISIP--------------------------MLGHPIYEAGIEKTM--HDYETLENLISTHDAIFLLTD---TRESRWLPTVISTAM-------------------------------DKLLINSAL-GFDSWLVMRHGSVLQKEN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLGCYFCNDIFAPSNSLVDR--------------------------------------------------------TLDQTCTVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSGCANIATAIAVELFVSLLQHPNGHAAP-------------------------------------------------------------VLNEDQTVLGELPHQIRGFLHNFSLMKISGM---AYPQCSACSEC|
68124197 Leishmania_major SRFNLELMKWRVL-PSLKLDQIARCKALLLGTGTLGCNVARNLLMWGV----------RDLTLVD-RGRVSFSNLARQSLFTFEA-AKDGKTKV-DAAAEAVRAIIPSA-VVRPVPLTIH--------------------------MPGHRIDEARADKAL--GEIRRLEELIAESDVVFLLTD---SREARWVPTIIAAAT-------------------------------GTPVINVAL-GFDTYVVMRHGVPGQTSRSNAVGEDDCRDTLHT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGCYFCSDIIAPTDSLSFR--------------------------------------------------------SLDEQCTVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPAVSSIASAIAVELLAELYQHPSGFRCPAYREAATG-----------------------------------------------------ESDQGRCRLGVIPQQIRGSVFSHTMHHLCGE---RNPFCTACADA|
123446747 Trichomonas_vaginalis_G3 TSLNLRLMKWRLC-PQLDVQKLQAQKCLLIGCGTLGCNVARYLLGWGV----------RKFVLID-YGKVSFSNPPRQSLFTFADCIDGGRSKC-EAAAKELKRICPDV-EAEYYEMPIP--------------------------MPGHPLGKNEYEKTR--KNVELLDKLIKECDCTWLLTD---TRESRWLPTLLATAN-------------------------------EKLCISVAL-GFDTFSVVRCGCH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLGCYFCNDVIAPTDTMTDR--------------------------------------------------------TLDMQCTVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGIAPMASSYGVELWASIVQTKEGVN---------------------------------------------------------------AEADADSVLGTVPHQLRCFLHSWQLLPMAGK---PFKNCVACSEP|
6321965 Saccharomyces_cerevisiae VDLNLKLMKWRIL-PDLNLDIIKNTKVLLLGAGTLGCYVSRALIAWGV----------RKITFVD-NGTVSYSNPVRQALYNFED---CGKPKA-ELAAASLKRIFPLM-DATGVKLSIP--------------------------MIGHKLVNE--EAQH--KDFDRLRALIKEHDIIFLLVD---SRESRWLPSLLSNIE-------------------------------NKTVINAAL-GFDSYLVMRHGNRDEQSSK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLGCYFCHDVVAPTDSLTDR--------------------------------------------------------TLDQMCTVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGVAMMASSLAVELMTSLLQTK-------------------------------------------------------------------YSGSETTVLGDIPHQIRGFLHNFSILKLETP---AYEHCPACSPK|
67476958 Entamoeba_histolytica_HM_1IMSS VDLNLQLMKWQLF-RNLDLPAIQATKCLLIGAGTLGCNVSRVLMGWGV----------QNITFVD-NGVISYSNPVRQSLYKFED-CIDKKYKA-QRAAEMVKEVFPGM-KSKGIVMSIP--------------------------MPGHPIGEKEIESTK--KDILLLDQLVQENDVVFLLGD---SRECRWLPSMLCSVY-------------------------------NKICITVGL-GFDSFVVMRHGDSSLDKEH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPSCYFCADIVAPTDSLSRR--------------------------------------------------------TLDQQCTVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGISYIASALAVEILISMIHHPL------------------------------------------------------------------HSKAPTSGEGYIPHQLRGYLNTWKIEEGVGS---AYSKCIACSEA|
66824909 Dictyostelium_discoideum_AX4 VDLNLKLMRWRVM-PSLELEKIKTTSCLLLGSGTLGCNVARSLMSWGV----------RNITFVD-SSKVSYSNPVRQSLFTFADCSPKAKEKS-IAAADALKKIFPAI-NANAHVFSIP--------------------------MPGHSVPQSEYQSIR--NTIELLENLIKQHDVIYLLTD---SRESRWLPTMLSRAH-------------------------------GKLCINAAL-GFDSYLVIRHGIKDQCQN-ELNPSISSKLGYQGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLGCYFCNDVIAPTDTLKDR--------------------------------------------------------TLDQMCTVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGLSMMASSIAVELLISTIHHPYGGRAKGETETD-------------------------------------------------------VYVQGSTPLGIIPHQLRGFISHYQTLPLFSN---PYKHCTACSDY|
19922550 Drosophila_melanogaster VNLNLKLMKWRLV-PDLNLEIISQTKCLLFGAGTLGCAVARNLLSWGF----------KHITLLD-SGKVGFSNPVRQNLYTHADAVAGNRMKA-TTAAQRLKEINPSA-ETAGYVLEIP--------------------------MPGHTIGESLLAQTK--EHLKVIEKLVQDHDVIFLLTD---SRESRWLPTLLGAAK-------------------------------EKIVINAAL-GFDSYLVMRHGTTRKEAG-DDGQEIEGLKCINGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLGCYFCNDVTAPGNSLKDR--------------------------------------------------------TLDQQCTVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGVSNIAASYAVELLVALLQHPRKELAPAYYAQSGRGRSEET-----------------------------------------------EEKVPEGLLGILPHSIRGMLCNYENILPATQ---KFAQCIACSAA|
17541546 Caenorhabditis_elegans VDLNLSLIKWRLH-PDIQLERYSQLKVLILGAGTLGCNIARCLIGWGV----------RHISFLD-NSTVSYNNPVRQSLSEFED-ARLGRGKA-ETAQAAIQRIFPSI-QATAHRLTVP--------------------------MPGHSIDEKDVPELE--KDIAKLEQLVKDHDVVFLALD---SREARWLPTVLASRH-------------------------------KKIAISVAI-GFDTYVIIRHGIGSRSESVSDVSSSDSVPYS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSCYFCSDVTAPGNSTFDR--------------------------------------------------------TLDQQCTVA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGTSMIASGIAVELLSSVLQYPDPLKTPA------------------------------------------------------------SHDDNTTVLGAAPHQIRGFLGRFQQILPSVK---RFDQCVACGDA|
18422607 Arabidopsis_thaliana VDLNLKLMRWRAL-PSLNLNVLSSVKCLLLGAGTLGCQVARTLMGWGI----------RNITFVD-YGKVAMSNPVRQSLYNFEDCLGRGEFKA-VAAVKSLKQIFPAM-ETSGVVMAIP--------------------------MPGHPISSQEEDSVL--GDCKRLSELIESHDAVFLLTD---TRESRWLPSLLCANA-------------------------------NKIAINAAL-GFDSYMVMRHGAGPTSLS-DDMQNLDINKTNTQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLGCYFCNDVVAPQDSMTDR--------------------------------------------------------TLDQQCTVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGLAPIAGALAVELLVGVLQHPLGINAKGDNSSLSN-----------------------------------------------------TGNNDDSPLGILPHQIRGSVSQFSQITLLGQ---ASNSCTACSET|
119584500 Homo_sapiens VDLNLKLMCWRLV-PTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGV----------RHITFVD-NAKISYSNPVRQPLYEFEDCLGGGKPKA-LAAADRLQKIFPGV-NARGFNMSIP--------------------------MPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMD---TRESRWLPAVIAASK-------------------------------RKLVINAAL-GFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLGCYFCNDVVAPGDSTRDR--------------------------------------------------------TLDQQCTVS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGLAVIAGALAVELMVSVLQHPEG--GYAIASSSDD-----------------------------------------------------RMNEPPTSLGLVPHQIRGFLSRFDNVLPVSL---AFDKCTACSSK|
22335385 Mus_musculus VDLNLKLMCWRLV-PTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGV----------RHVTFVD-NAKISYSNPVRQPLYEFEDCLGGGKPKA-LAAAERLQKIFPGV-NARGFNMSIP--------------------------MPGHPVNFSDVTMEQARRDVEQLEQLIDNHDVIFLLMD---TRESRWLPTVIAASK-------------------------------RKLVINAAL-GFDTFVVMRHGLKKPKQQGAGDLCPSHLVAPAD-LGSSLFANIPGY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLGCYFCNDVVAPGDSTRDR--------------------------------------------------------TLDQQCTVS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGLAVIAGALAVELMVSVLQHPEG--GYAIASSSDD-----------------------------------------------------RMNEPPTSLGLVPHQIRGFLSRFDNVLPVSL---AFDKCTACSPK|
58271168 Cryptococcus_neoformans_var_neoform VDLNLKLIKWRLL-PALDLDKISGTRCLLLGAGTLGCYVARILMGWGV----------RNITLVD-SSTVSYSNPVRQPLFTFSDCLNGGLPKA-PTAAKKLQEIFPGV-NAQGVVLGIP--------------------------MPGHPI-SSSDDAVE--KDVAKLEALVKSHDAVFLLMD---SRESRWLPTVLGRKW-------------------------------GKVVVNAAL-GFDSFLVMRHGAGAGAGA-RRIQSDEGGVGEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLGCYYCNDIVAPTDSLSDR--------------------------------------------------------TLDQMCTVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPGVAPIAAAMAVELLISVLQHPLGVHAPAERPDTAET----------------------------------------------------STSTKTSPLGCVPHQLRGQMYQWKTQIVEGE---AFDRCTGCSDY/
FINAL -HHHHHHHHHHHH-H---HHHHH---EEEEE-----HHHHHHHHHH-------------EEEEEE---EEE-----EEEEE----------HHH-HHHHHHHHHH--------EEHHHHHH------------------------------HHHHHHH-----------------H----EEEE----HHHHHHHHHHHHH-------------------------------------EEEEEEE----EEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE---EEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E--HHHHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------HHHHHHHHHEE-----------EEEEEEE--------EEEEE---\6A-MBL associated
68559822 Ralstonia_metallidurans_CH34 FHAHALSPELLAR-TSGIPYAATSQPLVVLGCGSVGSKVAMQLGRAGF----------GSMTFVD-NEPMSPHNAARHALIERASVL-VPPRKS-ALMKTAFESLSHL--QSRAFDTDAVT-------------------------LLVDPEQFAATV-----------------PQDAALIVDATASLQVLAAETQSAALD--------------------------------QSPARLARIAMYGQGRCVAVLLE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAGRAGRVDDLTAFLFECCRFAPELRASIAGETSEPTR-------------------------------------IFVGDNCHSLTM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMSDAVVSRSTSLAGLQLERWLVDGLP------------------------------------------------------------------KEATLCAGISDAE------GLGMAWTRAS-----LGPTTALEVAD|
86559649 Clostridium_perfringens KHLEPLTRNLAAN-ISTLSCK-KNPKILFVGAGALGSKIIFHLARNGY----------TDISVVD-NDILVPHNLVRHALFADS----ISKNKA-KEIINKLNNIYIM--DKNKNFKYY---------------------------SESFINFAINTD-----------------LSIYDVLIDCSASKSVFSFISEYSKKL----------------------------------PALVIRAELANKGKLGLVLKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NINRNLKIDDIQVSLFNYALSNTEVAEWLKNYQKLKENFEGAQFED-----------------------------ITIGMGCNTNTM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KISDNIISYHAAIFSSYIKKHITNDI-------------------------------------------------------------------QNGEFLISYFDEN-----NLSENYCKIIS-----VQDFISVNTSE|
77955723 Marinobacter_aquaeolei_VT8 QYIEAANPGLLQR-VSHRGQR-KHRSLHFIGVGSVGSKVALSLARTGN----------YGFHLTD-NSLFRGHNLSRHAIADPASN--LGFPKV-VYMKNAIESTLSV--ECTI--------------------------------SADDASSPTFTI-----------------PGAPDAIIESTGAAAVAANLRWIPFDA------------------------------------QLYQVGVYAEAELAFLSAEPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DQSRGVRVDDLEAWLFQQAFQNRAIGRLLFAENEHSR--------------------------------------MIVGPGCSSVTT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVSDPKLSLQVSAITERLDRTLQAWPY------------------------------------------------------------------DDDRGLAAYCVRDP----KSGNLSWTSTQ-----LGKTHSHSCKR|
48864353 Microbulbifer_degradans_2_40 LMIKSTCPAMLRA-VSGVEQDAEAIPISFIGCGSLGSKMALHLAKSGR----------YEFSLID-DDIFSSHNNARYGAVVDGFDS-IGCPKV-TLVARDIQALGVR--VEPLKVD-----------------------------VLELGKSKPAIA-----------------DKKFRYILDTSASLPVRYFLAHHAKLS-----------------------------------ACLMHSILYGKATMGVLAIE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKERSVRVDDLMAYTNTLCVKDDLVQKAMYGGAITR---------------------------------------ESFGDGCSSATT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMDDIGLSILSAALAGKVNQHIGENT-------------------------------------------------------------------GPGEGLLNIGHLD-----KDYNLEWTSHV-----LPATHVISRDT|
90019857 Saccharophagus_degradans_2_40 LMIKSTCPAMLRA-VSGVEQDAEAIPISFIGCGSLGSKMALHLAKSGR----------YEFSLID-DDIFSSHNNARYGAVVDGFDS-IGCPKV-TLVARDIQALGVR--VEPLKVD-----------------------------VLELGKSKPAIA-----------------DKKFRYILDTSASLPVRYFLAHHAKLS-----------------------------------ACLMHSILYGKATMGVLAIE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKERSVRVDDLMAYTNTLCVKDDLVQKAMYGGAITR---------------------------------------ESFGDGCSSATT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMDDIGLSILSAALAGKVNQHIGENT-------------------------------------------------------------------GPGEGLLNIGHLD-----KDYNLEWTSHV-----LPATHVISRDT|
88705878 gamma_proteobacterium_KT_71 FHAHALSPELLAR-ASGIPAAATSQPLVMLGCGSLGSKIAMQLGRAGF----------GSMTFVD-NESMSPHNAARHALIERGPML-VPPRKS-TLMKTAFEELSHL--QSRAFDADAVT-------------------------LLVDPEQFATTV-----------------PQDASLIVDTTASLQVLAAGTQSAALD--------------------------------QSPARLVRVAMYGQGRCVAVLLE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSGRAGRVDDLTAFLFECCRFTPELRASIAGDTSEPTR-------------------------------------IFVGDNCRSLTM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMSDAVVSRSASLAGLQLERWLVDGLP------------------------------------------------------------------EEATLCAGFSDAE------GLGMAWSRTS-----LGSTTVLDVAD|
21110358 Xanthomonas_axonopodis_pv_citr DVSRSLDRDEAKR-WSGIED--GEFRGVIAGVGALGSALIDIWSRSAW----------GHWDYID-PDVLAQHNVVRHVGTQDQ----VGLPKV-EVAKRHARRTLGF--ADPDVKALQNR-------------------------ASDLDTEPVRAC-----------------LKRGDLLIDASTTIQVTRAWSGAD-LP----------------------------------RGMAAFLTPSGDGCVLIAE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSAQEIRGASLEAQYYRAII-QQDWGAVHLEAKGRP---------------------------------------LRSGAGCRDVSV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGYDQVLRSASL----LARQIRNRS-------------------------------------------------------------------MLSGASIDVWESS-----SDGSILHIEVA-----ARRTFSKKVGD|
77955313 Marinobacter_aquaeolei_VT8 GIRLMPSKQEVRE-YSGIAESPCDFSGVISGLGSLGSAVASIWARESW----------GDWEYVD-HDAIEPHNLSRHIALGPC----VGMAKS-EMMSMQAASMFSL--EGSEMSKKNAHVR-----------------------KFTDDLQWLDGL-----------------LEDKDIVIDASTTVEVPRDLSGMDRSA----------------------------------RLATIFITPSGSSSVLLME----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DQSGYIRSLSLEAQYYRAILTNDSWGVHHLEGNRGY---------------------------------------LWVGAGCRDITM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMSNELVSLHASI----LARQVRLLS-------------------------------------------------------------------DKEEAQIKIWDYDG----LSGSVRAHDIQ-----ACKPKHAEVGG|
84717800 Polaromonas_naphthalenivorans_ AVLSQNDAAAARK-QSGITE--EGPAGALVGAGSLGSAILNFWGRAGW----------GSWTVID-KDHIKPHNLSRHVAYAQH----IGYPKA-TVVA-DLHAAAMH--GASEITPLNAD-------------------------ASDFKPGAVTDA-----------------LSSVKLVVDASTTLEYPRAASMVDGFA----------------------------------RHFSVFVTPTGNAGILLAE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAQRLLRLRTLEAQYYRALI-QENWGRNHLTDNTGS---------------------------------------FWSGASCRDISV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIPYSRIMGQAST----LAEQIPLAA-------------------------------------------------------------------AQDGAMIRVWQRDP----VRGTVEVHDVP-----VATERRMQLGE|
58038271 Gluconobacter_oxydans_621H RIVQRLNRETARR-FAGSTRT-ADAKLVAIGAGAIGSNVIINTTHAGL----------GTWTIID-DDDVLPHNTVRQTQTNCA----VGYSKA-QVLALEADAILAE--SGNHSIIADVF-------------------------HAGAEAGQIAHA-----------------MLGADLVVDFSASPAVVGYLADRE-LG----------------------------------RASSFFFGPDGSDLVAMDE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNGRAVRLDEVEAQYFLAVATYPALEGHLSTARTDR---------------------------------------IRYANACQDLSR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPPWQVQMLSGL----AAGRLPSFV-------------------------------------------------------------------EDAAPSAWVWRLNP----ETGSVLPTSLS-----VQPTFRFGSDE|
84502025 Oceanicola_batsensis_HTCC2597 EVHATFDRDLATR-LAGRAIP-DARKAVIVGGGAIGAHVAPCLTREGR----------FRWTVID-DDVLLPHNLARHVGFGGD----VTRRKS-ELLAGALASILDD--EDSVATAITAQVG-----------------------VEGQQNDDVNAA-----------------LDGADIIVDASASLLAERFLSDHNSKA----------------------------------RRFSIFFSPAGDAAVLLAE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIDRSVTLRDLEAQYLRHVVREEALSGHLETPVRT----------------------------------------FAYTGACRAITN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIPESRVMALSGL----VAEGLGRAA-------------------------------------------------------------------DTDEGIIRIWSLG-----TEGQVRSFSYP-----AEDVRRFDVDG|
90419011 Aurantimonas_sp_SI85_9A1 PVHLQLNAARATI-MSGREVT-VTRRVAMIGAGSLGSSLAEMLVREGQ----------FQWTIID-DDFFLPHNVSRHTLIADD----LGRSKV-SRLASRLHSIRGD--ADLIPIHENV--------------------------LRGGPDGKAAGA-----------------LDSADLIVDASASVTVSRWLVDRPSTP----------------------------------RVLSTFFTPAGRSAVLMCE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SADRKVTLRDVEAVYLREVLTNPSLHDHHQSGQQ-----------------------------------------MRFTGACRALTN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIPTSSVAVLSGL----IAGSVPEAS-------------------------------------------------------------------TAEDPALKIWTMR-----DDGAIDCLPVP-----VATVRAEAADW/
FINAL -HHHHHHHH---------HHHHH---EEEEEE----HHHHHHHHHH-------------EEEEE-----EE-----EEEHHHHH-------HHH-HHHHHHHHH----E-EEEEHHHHH----------------------------HHHHHHHHH---------------------EEEEE------HHHHHHHHHHHHH--------------------------------EEEEEEEEE-----EEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE-HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHH------------------------------------------------------HHHHHHHHHHH----------------E------------------\6B-nuct. transferase associated
78684828 Shewanella_sp_ANA_3 ENTVERGGG---------ILSLADKKVAVIGVGSVGCEIAHKLSAAGV----------RHLTLVD-PDVYEINNLYRHVLEQHW----VGAPKT-AALSVALQRQFPWS-CAQWKLDKL----------------------------MEFARSSRMND-----------------FDLIVIAIG---NPTQERLFKQYLLDNNSKV---------------------------AVMNSWLEGFGVGGHATLDIPS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGCLLCSYVCQETGVRGLVSNMNFIEPNQVTM-------------------------------------------KNIAGCGEQFI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SYGAASSAQTAVMAANLAIRYLEGKQAKSCKVSWKGLD------------------------------------------------------EDAMAEGIRLTHRYYNF----SSSLEYLPL-----VDEDCDVCTH-|
86475968 Clostridium_perfringens EYLLGRGGI---------ERVFSNKKILVIGCGSVGGYLVDELVKSGF----------LNICLVD-YDILSYNNIYRHLLGLEY----IGEYKT-TAIIRYLSKNLPHA-KVISHEDSIR--------------------------LLLEEGSLELSD-----------------FDLIISSTG---DINLNRWLNKYIKIKKIIT---------------------------PVIYLWNEALGIGSHALYIKDN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLGCFECTIGKDELGIYDKTSYFERGQTFT----------------------------------------------KKMNSCNSTFV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYGSIHSVRTAILGVDIAIKHMNGNIKENFLISIKDDG------------------------------------------------------TVYLKENLKLSNRY------IKQKNKQQIISGENFDRKNCFICKRK|
88937743 Geobacter_uraniumreducens_Rf4 EYLLPRGGS---------NLALREKRVLLLGCGSVGGFIANELTRAGI----------LRLTVLD-KDVLTHENLFRHVLGKKH----VGKNKV-DGIKDDIEGRLPFV-EVLPIPLSLE--------------------------NALESGKIKIGD-----------------FDLIISALG---NVTVELVFSKYIHGIDSP----------------------------PVIFTWLEPYGIGGHALLTRNGS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKGCLKCLYQPEDGDLRCRASFAEKGQSFA----------------------------------------------KNINGCRNVFT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFGSLDAMKTAELATRLAIATLNGDIKTNLIRSWRGDA------------------------------------------------------TEFLKNGKKLSSRY--------SASNDHFIEEANYHFEECPVCHEP|
71038912 Psychrobacter_arcticus_273_4 ETILTRNRS------KPEIGDLRSKKIALIGCGTVGGYAAELLIRAGAGMGE------KVFDLYD-ADEFGPENFSRHTLSSRD----FGKNKA-VAMKERLDSSTHLT-TNIQGHARK-----------------------------FEFLLNKLTA-----------------YDIIIDATG---RAPISKRLAYLLRQLGGVK---------------------------KPVIIHAFNDGNGVASKIFIDS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDGCYNCLCGDERFYKNGNDKRFEKLNGIP----------------------------------------------EKKVSCGNTYT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYDAAVSVVTAALIQEAVLSTLEHKR------------------------------------------------------------------DWNYKEHIFFMGSR--------SKRTTWIS-----KQAFCDICNGR|
9654584 Vibrio_cholerae_O1_biovar_eltor_st DTLLSRNQS------RPDVGNLSQKRIALIGCGTIGGYLAELLLRSGAGCGE------NYFHLYD-NDSFKPHNFARHSLTAHN----FGLAKS-IALANSLKEAVHIA-QSIKGIDRQ-----------------------------FPIQADVLSK-----------------YDIVIDATG---RPPVSKRLAAVARTLIADI---------------------------RPVLIHAFNDGNGRASKVLVDD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRCCYGCMMADPAVYRNNIDLRFEGIDLAK----------------------------------------------EKHISCGSTYT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYDAAVSHITAALAQEAVLNTLEHTL-------------------------------------------------------------------PWNYSEHMLDGSR--------SKKPRTLK-----RFSGCNICDE-|
85706659 Roseovarius_sp_217 DEITARNLD--------MAAPLTGRRLAMIGCGTIGGYLARALVQLGAGQG-------TALLLID-HDNLKPENLGRHILGARH----LWRNKA-VALIDQLGSDFPDA-KLEAVAARA------------------------------QGTFDRLAG-----------------YDLVIDATG---DEQFSDALNAFALSRIGAAERFP-----------------------KTLFTMLFGNGLAAQSYLARWET---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKACYRCLKPRFEGEWRFNPLRPESKETG-----------------------------------------------VAVRPCAQGSF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPYAVPASMQAAALAASHASEVFLDRYD----------------------------------------------------------------YDLRTVRVDPSATV--------QVPFRNIE-----RAKICSACST-|
84786718 Erythrobacter_litoralis_HTCC2594 AEIAQRNLH--------GIKTLDGKAIALVGCGTLGSHLAKFLIQSGAGAG-------APLTLID-GQVLSAGNIGRHYLGHSR----IGERKA-SALAEELRSFHPQC-DIRATVGDA------------------------------LAQKAVLAD-----------------SDLLVDATG---DWNTQYALNELFYEDDISAE--------------------------AILHCWISGNGAAVQAFLNVRG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDCCFRCLRPSMDAGPRFPALKPGVEAN------------------------------------------------MAPATCGDGNY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPYSVAAPAIAAGLACDMAIGWANDK------------------------------------------------------------------PGARLRTIVLDHERG------IERKPTSPS-----AHKTCPSCLSR|
22726448 Ruegeria_sp_PR1b PTAKERRVH---------GKMFRESSICIIGAGSLGSKVAASLAREGV----------GQFILFD-NDVLWSDNLVRNELDEMD----VGHHKA-VSLRHRLLRINPAV-KVGALGMSLTSQSAV---------------------QHIAQLSEIIST-----------------CDLVIDTTA---DSGVFRMAAAICTQKRK-----------------------------PLVWGRVYAGGLGGLIARSIPS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDPPPLTAASQLRAWCEEKGMAPPEGREHNYG--------------------------------------------VQGDDDDEPLF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASDG-DVGVIANRLVRHALDALSTTEIRVHPEPAY---------------------------------------------------------FIGLRKGWIFDHPFDTHP---VIFGPTDGWAI---DSTSCAEEGVE|
86357617 Rhizobium_etli_CFN_42 PETGLRSGR---------APSAQAKKVAVVGAGSVGSKVAEMLLRSGI----------DTLRIFD-GDVFLPGNLERHVLDWRD----VGYHKV-HGLKRRLLHIVPGA-DIMTIDQNLNWQKSA---------------------RTNALHFDLITA-----------------CDIIVDASG---DPATSMLLGALAFENKK-----------------------------PFVSVEVFEGGIGALVAPSVPE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNAAYTLGREALLNWTDEKGRVVPLSAGDRAY--------------------------------------------EAISDDGDIIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADDA-AISMAASHAARVVLDILDDKLDDFRWL------------------------------------------------------------LIGFRKEWAFDMHGHVIA---LDVGGPSEW-----NNNTEDADAQK|
84499281 Oceanicola_batsensis_HTCC2597 DEGGLRAAA---------KSPRDDKSVSIVGAGSVGSKIAESLVRSGV----------RRLQIAD-GDVMLPGNLERHVLDWRD----VGGRKV-HALKKRLLNISPGA-SISITPSNLNWQRSA---------------------VAHAWQVEDIAE-----------------GKVIVDATG---DPATSLLLGAIAHANKR-----------------------------PFVSVEVFEGGIGGLVAAVIPE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDPPFAEGRATFLSWCHEQDQPPP-AAGPRSY--------------------------------------------EALTPDGIPMA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADDA-AVSTIAGHAARVILDVLDGNPPRPEAAWL----------------------------------------------------------LLGLQESWLFEGHGHTIR---LSVGFQAET-----PVKQDDEEAKK|
92915671 Mycobacterium_sp_KMS PEVTTRRDD------GRPVNGFQRKTVHIWGCGGLGSWIAEFIARAGA----------SEITVCD-PGIVTGGLLVRQNYVEDD----IGRSKA-EALAGRLRAIRDDL-TVTVAEGHL------------------------------PEDHTSCLA-----------------ADLIIDATV---NNGITSCLDALATAPTRKALI-------------------------AQVATDARSGTLGLAVLCAASA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TATVSSIDQDAGRTIQGDSGLELYHTLWQE----------------------------------------PSDDELIPTRGCSVPTF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGSAADLVAVAATLVNLIGSHLQQPDS-----------------------------------------------------------------AVSGTHLIALPHAA--------SGPRHHFL-----PGVTHPMDHTA/
FINAL -----------------HHHHHHH--EEEEE-----HHHHHHHHHH-------------EEEEE----EEE---HHHHHHHH---------HHH-HHHHHHHH--------EEEE---H---------------------------HHHHHHH-----------------------EEEEEE-----HHHHHHHHH-------------------------------------EEEEE--------EEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEE-----------EEEE------HHHHHHHHHHHH------HHHHHHHHHHH------------HHHHHHHH------EEEEEE---EEEEEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEEHHHHHHHHHHHHHHHHHH-----------------------------------------------------------------------------EEEEE---------------------------E-EE---\6C-mobile element
86359719 Rhizobium_etli_CFN_42 LFDYAPGSR-----ANPPLSDTALDDLFLLGLGAIGNGAVWALSRVPHLQ--------GHLQVVD-GEQVDQGNLQRYVLALERD---IGQSKV-KLAWRYLKAQRN---LTIDGHSAR---------------------------WQTLPIIRSM--------------------QHVAVALD---TAADRIAVQGTLP---------------------------------RWTINSWTQRGDLGVSHHGFEG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMACLACLYIPNGTVPDEDQVIAEALGLEDRKIDIVRPMLHDGAPVSEELMRDIASRLTVPVEPLLQFVDQPLRNLYRGAICGGVVFELTAGSKPVRVE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPMAFQSAMAGIMLAGEIIKQAAGNA-------------------------------------------------------------------PDWTT-AKLNLLRNIPS---DIVTERRKKD----RLGRC-ICQDE|
2496664 Rhizobium_sp_NGR234 LYSYNKTKARD---ARPVDLPVDLGETHLVGLGAIGHGALWALARQSGLS--------GRLHVVD-HEAVELSNLQRYVLAGQAE---IGMSKA-VLATTALRS-TA---LEVEAHPLK---------------------------WAEHVARRGDWI-----------------FDRVGVALD---TAADRLAVQGALP---------------------------------RWIANAWTQEHDLGISRHGFDD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQACLCCMYMPSGKSKDEHQLIAEELGIPETH-EQVKALLQTNAGVPNDFVVRVATAMGVPFEPLAPFVGQPLRSFYQQAICGGLVFQLSDGSRLVRTV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPMAFQSALAGIMLAAELVKHSAGFP-------------------------------------------------------------------MSPTTSTRVNLLRPLG----SHLHDPKAKD----SSGRC-ICSDE|
14025925 Mesorhizobium_loti_MAFF303099 LYSYDKTKAGE---AGPIDIPVDLGETHLVGLGAIGHGSLWALARQPGLT--------GRLHVID-HEAIELSNLQRYVLAGQAE---IGMSKA-VLAATALRS-TA---IGVEAHPLT---------------------------WAEYVARHGDWV-----------------FDRVGVALD---TAADRLAVQGALP---------------------------------RWIANAWTQEHDLGISRHGFDD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQACLCCMYLPSGKSKDEHHLIAEELGIPEAH-EQVKTLLQTNAGVPNDFVVRVATAMAVPFEPLAPFVGQPLRSFYQQAICGGLVFQLSDGSRRVRTV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPMAFQSALAGIMLAAELVKHSAGFP-------------------------------------------------------------------VGPTTSTRVNLLRPLG----SRLHDPKAKD----SSGRC-ICSDD|
20803932 Mesorhizobium_loti LYSYDKTRAGE---AGPIDIPVDLGETHLVGLGAIGHGSLWALARQPGLT--------GRLHVID-HEAIELSNLQRYALAGQAE---IGMSKA-VLAATALRS-TA---LGVEAHPLT---------------------------WAEYVARHGDWV-----------------FDRVGVALD---TAADRLAVQGALP---------------------------------RWIANAWTQEHDLGISRHGFDD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQACLCCMYLPSGKSKDEHQLIAEELGIPEAH-EQVKTLLQTNAGVPNDFVVRVATAMAVPFEPLAPFVGQPLRSFYQQAICGGLVFQLSDGSRRVRTV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPMAFQSALAGIMLAAELVKHSAGFP-------------------------------------------------------------------VGPTTSTRVNLLRPLG----SHLHDPKAKD----SSGRC-ICSDD|
77690158 Rhodopseudomonas_palustris_BisB5 ------QLGVP---NGALDLRVDVGHAVMAGAGAVAH-AFLKAARHIDIH--------GDLAIVD-PKVVQGGILNRCLYLEDND---VDRQKAEVLAERAQRDFPH---LRLLPFVTD---------------------------FKAYVRQLGH-P-----------------PETVFVTVD---SRLVRRSIQLEVP---------------------------------RRIIDASTTDAS-GVIVHSNVLPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QHACLACIYRHVPEEHARERSIAEGLGVD---------LADVQAGLITAEVARRIVRTHKSIDG-DAIVGLAFDSLFRQ-LCSEQALATPEGRQ---VL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APFAFVSAWAGVMMAVEMLRSFAGAA-----------------------------------------------------------------------KTNYWSVDPWNT----PKARGRMLRQ----RHPECQFCSKP/
FINAL -------HHHHHH-HHHHHH-----EEEEEEE----HHHHHHHHHHHHHHHH-------EEEEEE---EEE-------EEEE---------HHH-HHHHHHHHH-------EEEEE--E------H-HHHHHH--------------------------------------------EEEEE-----HHHHHHHHHHHHHH----------------------------------EEEEEE------EEEEEEE------EEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHH----HHHHHHHHHHHHHHHHHHHH-------------------------------------------------------------------HHHHHHHHHHHH--------------EE----------------\6D-E2, E1, JAB associated
71847773 Dechloromonas_aromatica_RCB --------MEH---LIDPALLDRRVSIHLVGVGGNGAQMAACLARLDIAMKAFGHPYGLHVTAFD-ADRVSEANVGRQLYSPAD----IGRHKA-IVTIHRLNQFYGL---DWIAHPTRYE-------------------------AFETNRYSP-LS-----------------ADILVSCVD---SRSARRILHEAVFDGGGR----------------------------YRYWLDLGNTEASAQVVLGQGP---------RRAKGEVNLRLPCVTE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFPELLDASV-PD---------------------------------------------------------------DNRPSCSVR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSLVSQGLFINDVAVRFAAQLLYELFSK----------------------------------------------------------------GRLDQHGVVVNLDS---------KRTGPIEV-----DPKTWARFGC|
71839551 Pelobacter_propionicus_DSM_2379 -------MKRH---TTDWKLLSRQVNVALVGCGGVGASVLPGLAKLHTAITALGHPGGLHVTVYD-PDTVSKSNIGRQNYSPSD----VGINKA-VLSVHRINSFYGF---NWSAEPTY------------------------------FPGPPS-RN-----------------IDLVVSCVD---TKAARRNIAEYCRRVN------------------------------VPYWLDYGNDLVTGQVILGQPL-------WIGEKKRERPMRLPTVTE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFPEIMDAQI-PE---------------------------------------------------------------DDTPSCSLE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EALSRQDLFIGQTCAVFGLDLLWRLFRE----------------------------------------------------------------AGIDNHGAFINLKS---------GRVMPLPV-----DKEAWKRFAP|
67908646 Polaromonas_sp_JS666 --------MEH---AINPQLLQKTISVALVGAGGTGSQVITALAQMHYALVKLGHPGGLSVTVYD-DDRVSESNIGRQWFFPAD----LGQYKA-DVLVQRVNMTMGT---DWTSCPSK------------------------------VSMSDT-LH-----------------FDIVIGAVD---TRKARLSIMRAMERGPS-----------------------------GAYYLDFGNRAKDGQAILGQVV---------GANRKTNGGTLPHVGE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFPEVMDPKVVDP---------------------------------------------------------------DEGPSCSLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EALARQSLFINRTLVSHGMAMLWDLLRH----------------------------------------------------------------HKITFHGVFVNLET---------GRVTSLPV-----CEKAWARFGY|
56315654 Azoarcus_sp_EbN1 --------MEH---FIIPDLLQRKVRIVVVGAGGTGSHVINGLVQLHTALLALGHPAGLHVTAFD-DDTVSESNVGRQAFAWSD----IGANKA-SVLINRLNQAFGL---DWEACPER---------------------------IGVSRTGRLRMR-----------------PDLVIGCVD---NRLARKAIASTFG---------------------------------YGYWLDIGNNQNDGQVILGEIG-----EGHYVTWHGKKRLRLPTVAD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLPEAVDERLDQT---------------------------------------------------------------DDQPSCSLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DALEKQSLFINRAMALHALNLLWKLFRL----------------------------------------------------------------ARLEAHGVFVNLAT---------DRSSPLMI-----DPEAWGRFGY|
67543575 Burkholderia_vietnamiensis_G4 ------EVITH---SIPADMLRRPWRVVVVGAGGTGSAFLPSLARLHHAMIELGHPGGIECTVYD-DDTVSETNVGRQGFYPND----VGHYKA-LLLVNRLNNLMGT---NWVAEPRR-----------------------------VDSSVRIV-------------------ADVVVGCVD---SRRARHAIVQAAKRGS------------------------------CRYYLDCGNETDRGQVILGEFG-------------KARHDRLPHVGD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFPDLLNAKNDRD---------------------------------------------------------------DDTPSCSMA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DALRKQSLVINQAISVQAYNLLWTLYRT----------------------------------------------------------------GSLKYSGSFVNLET---------GRTSPISI-----DPAAWARFGY|
56410326 Ralstonia_metallidurans_CH34 ------MTFVH---RIPEDMLLRAWRVSVVGAGGTGSALLPNLARLHHAMLELGHPGGIDCTVYD-DDTVSETNVGRQGFYPVD----VGQYKA-TLIVNRLNNLMGT---RWEAHTRR-----------------------------VGSGDRFV-------------------CDMVIGCVD---SRAARKAIVGAMQRGA------------------------------GGYYLDCGNNADDGQVILGQIG-------------GKAKERLPHVGD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LYPQLLDPKGDKA---------------------------------------------------------------DTAPSCSMA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EALQKQSLVINMAIAVQAYNLLWTLFRT----------------------------------------------------------------GTLQNCGAFVNLLT---------GRTSPLPV-----DPVVWERFGY|
75705486 Anabaena_variabilis_ATCC_29413 ----LTTYQQA---LPVLPRNHTRINFVLVGVGGTGGFLAEDLCRIILQLQHTRK--EINFAIVD-GDTVELKNISRQNYQQAE----IGLPKA-ETLAARCSAKYGI---EITAVCDWFEED-------------------------MIRTASWWNT-----------------LTVIIGCVD---NSAARSKIHSVLKINSANEPA-------------------------SLFWLDCGNSNYSGQVVIGTHSNFDIVQASNNPDKPQFWLHLPSPVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHPELLVPQPEELS--------------------------------------------------------------DNNLSCAEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QARNYQSLFVNKMTSAIAAQYLLELTLT----------------------------------------------------------------GGLKKFASYFDLKA---------MSTRSLYT-----SIDQLKKYYI|
29339961 Bacteroides_thetaiotaomicron ----MKKIHYT---DNYLLKPYHPVTIHVAGAGGTGSQVITNLARMNVALQALGHP-GLHVTVFD-PDIITEANIGRQLFSEME----LGQGKA-TAAVTRVNRFFGT---TWTAENCRYPVRK-----------------------TQENGDDRTKP-----------------ANIIITCTD---NTRSRLELWRFLKKYRETSVNNERA---------------------VYYWMDFGNAQTTGQVFIGTVR------NKIRQPASKEFMPVPGMNV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITEEVNYSTIEEK---------------------------------------------------------------DSEPSCSLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EALERQDLYINSILAQVGCDILWRMFKE----------------------------------------------------------------GRTLYRGAYINLDT---------LRVNPIPV---------------/
FINAL --HHHHHHHHH---HHHHHHHHH---EEEEEE----HHHHHHHHHH-------------EEEEE-----EEE-------E--HHHH----H-HH-HHHHHHHHH-------EEEEEE--------------------------------HHHHHHHH--------------------EEEEEE------HHHHHHHHHHHHH-----------------------------------EEEEEEEEEE------EE--EE--EEEEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE----------------------HHH--------------------------------------------HHH--EE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE-HHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------H---HHHHHHHHHH-------HHHHHHH------------------\6E-polyubi associated
84711629 Polaromonas_naphthalenivorans_CJ2 TEFLARQAALF---GKGFNPIVRALRVGVIGCGGTGSAVVSLLTRLGV----------GHLALMD-NDTIDTTNLNRVHGSRAADVP-AKLAKV-DILAREIEAGGLG--TQVVTRRAW---------------------------VGDPSLRDVLRS-----------------CDVLFGCTD---DNQGRLTLNRLAHYY-------------------------------GIPLIDVGLRMRSAKSGVDYDMT---GRVTTIRP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNPCLICLGVVNAQRAAAEGLQRNDPAEFERR--------------------------------------------KAEAYVEGGGDPA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAVVTFTTSIACAAVDELIQGLTGFR------------------------------------------------------------------GQGGMTHNRIRRFD-------RVEDRSMTCR----PIPTCPVCGTE|
17134589 Nostoc_sp_PCC_7120 PPALQRQALAF---GEALNQDLSMLRVGVIGCGGTGSAIAMLLPKMGI----------RNIALFD-KDIVEDTNLNRLHGARQPDAD-AMSPKV-EVVAKSLVELGLG--VQVRTYQAW---------------------------IGEADCRDPLKA-----------------CDVIFCCTD---DHTGRLMLNRFAYYY-------------------------------ATPVFDMGLAIEVSQGETPNFQA-LDGRVTVLVPAP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHACLLCREIINPVIARDEALKRSNPDEYERR--------------------------------------------KAEAYVIGEGNPS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAVVLFTTEVAIMAMQELVHRLQGFR------------------------------------------------------------------GEDGAAAHRVRKFH-------LTTDRKPAAI----LNSNCPVCGTV|
38423902 Synechocystis_sp_PCC_6803 SPIFQRQALAF---GEALTQDLSTLRIGIVGCGGTGSAVAMLLPKLGV----------RQIALFD-QDIVEFTNLNRLHGATFNDAQ-EGLPKV-EVIRRSLTDLGIG--VEVRTYRAW---------------------------INDPMCQDALKT-----------------CDIIFGCTD---DHAGRLLLNRFAYYY-------------------------------LTPIFDVGLAIEVDRSETLRMQA-LDGRVTTLIP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNTCLLCREIINPEQAFGESLKREQPEEYKRR--------------------------------------------KEEAYVIGEGNPS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAVVLFTTDVANMAIQELVHRLQGFR------------------------------------------------------------------GKNGAIANRVKKYH-------LREDRQLGAS----ADVNCPLCSTD|
67547439 Burkholderia_vietnamiensis_G4 PEHALRLIQTF---GEGTYRTLRQLRIGVAGASGTGSIILEQLARNCV----------GELVPVD-PDHLERKNLNRVLNARGSDAD-KKRLKV-ERAQEAILEMDLG--TKVCPLPND---------------------------IIDRETILALGE-----------------CDVLFGCLD---SVDGRHILNKIASHF-------------------------------LIPLIDIGVRIDADGKGNVDHVT---GAVHTVQP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGSSLMSRGVYSQADLDAAFMKKHEPERYKEM--------------------------------------------RKAGYVRGTDVDR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAVISLNMLVAAYAVNELLARLMPFR------------------------------------------------------------------VEPNAEFAQWR-IS-------LSDPLATNYRG---DGAACAAFAK-|
69928900 Nitrobacter_hamburgensis_X14 SDHQGGPPMAF---TSEMTAANQHLSVAVIGASGTGSIIIEQVARLGF----------GRIVVID-FDKIEGKNLNRILNTSCAD---VGRFKV-EVMANAAASHRGN--GTVIPMPTS---------------------------ILDREAVIAASD-----------------CDFVFCCVD---TLEARLVADLISAMF-------------------------------LMPLVDMGVVIPVRRHGGDVRIADVYGRIDYVYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGATLEDRGVYDPERLREEYLRTHAPDAHRFE--------------------------------------------VRDGYIKGIAEEA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSVITLNMRVAAMAVGELLARLYPFR------------------------------------------------------------------HEANRRYARTT-FS-------LA-ACEEEYF----AEEAFTASGAI|
39651044 Rhodopseudomonas_palustris_CGA009 KIHDTMTSRAE---ITALSAKFKDEVIAIIGLGGTGAYILDFMVKTPV----------KEIRGFD-LDPFHVHNAFRSPGRFEDSE--FKRSKA-DVYQTRYDNFRHG--LTLKAK------------------------------FIDASCASDFDG-----------------VTFAFVCVD---KGSSRAGIFEVLMAK-------------------------------GIPFIDVGMGLNRKRGPLAGMM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RATYYDPANAQAM--------------------------------------------------------------KDKGFSELSDRPN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-EYRVNIQIGELNALNATLAVIKYK------------------------------------------------------------------KLKGFYIETNPDFN-------FLFDLSDCKI----TRRSKIDEA--|
14025879 Mesorhizobium_loti_MAFF303099 AIPDSASARYG---IVAANRKLRG-RVAIIGLGGTGAYLLDLAAKTRV----------AEIHLYD-DDQLLNHNLFRSPGAPEPVLAKNFPRKV-DYYAALYARMHKG--VKPHPT------------------------------RVKADNIDEFAG-----------------YDFVFVCVD---KGSSRRVIAEGLVRL-------------------------------GIPFVDTGIGLGLEHNTLDGCA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RATFIAPGTPWAE--------------------------------------------------------------VATHLSFGDDDEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYGTEIQTAELNSLNAIMAIMRWK------------------------------------------------------------------RWLTFYRDERNERN-------ATYMIEGNNI----TNRGA------|
88795472 Alteromonas_macleodii NYIDTNSGRAG---ITAISSTLKEQKIGVIGLGGTGSYILDFVAKTPV----------QEIHLFD-ADDFVQHNAFRSPGAASLSELRERQSKV-DYHKSRYQKMHRG--IVSHAC------------------------------FIDEDNVDMLRG-----------------LDFVFISID---EGSAKKVIFNYLTAQ-------------------------------KIAFVDVGIGIEVANDKLTGIL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTTLSTPDKNS----------------------------------------------------------------HVDNYVPYQTGEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-EYASNIQISELNALNAVLAVIKWK------------------------------------------------------------------KVCGYYHDHIKEYN-------STYTINAHML----VGEEEFAA---|
28806072 Vibrio_parahaemolyticus_RIMD NYTETASGRVG---IGALSDLLTEESVAIIGLGGTGSYILDLVAKTPV----------REILLFD-SDEFLQHNAFRAPGAPTLEALRDAEKKV-EYFKSIYSNMHKR--ISTSST------------------------------YIDEENLELLNG-----------------VTFAFICID---AGTSKKSIVQKLEEL-------------------------------DIPFVDVGMGVELTDGSLGGIL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVTASTSGKRQH---------------------------------------------------------------VHEGRVSFGGGEG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDVYSSNIQVADLNALNAALAVIKWK------------------------------------------------------------------KIRGFYRDLEQEHH-------STYTTDGNLL----LNGESCA----|
68554445 Ralstonia_metallidurans_CH34 NYVENASGRAG---IDKLTALLAGDCVAIIGLGGTGSYVLDFVAKTPV----------REIRLID-GDDFLQHNAFRAPGAPTAEQLREVPKKV-DHFRSIYANMHRG--IAAHAV------------------------------ALDASTVGLLTG-----------------VTFAFLCMD---AGHGKRIAIDQLESL-------------------------------GVPFVDVGMGLELSNGTLGGIL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSLSTPDCRD----------------------------------------------------------------IARSTISFDEPDR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGIYSSNIQVADLNAMNAVMAVMRWK------------------------------------------------------------------RYRNFYRDFEGEFH-------SSFTTDVNML----LNGEPK-----/
1jw9B.pdb (MOCS3/MoeB/ThiF) -HHHHHHHHHHHEEEEEE-HHHHHHHHHHHHHHH-----------EEEEEEE--------------------------HHH-HHHHHHHHHHH-----EEEEE-------------------------------HHHHHHHHHHH-------------------EEEEE-----HHHHHHHHHHHHHHH-------------------------------H-EEEEEEEE-EEEEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHH------------------------------------------------------------------------EEEEEEEE----------EEEEEEE-----------------\ThiF/MoeB/
83315401 Plasmodium_yoelii_yoelii_str_17XNL VEKHGKYINIEEI-NTNSLNTIFKTKILIIGIGGLGSPICFYLSKFGF----------SEIGLVD-GDKVEKSNLHRQIIHKKKN---IGLNKT-ISAKLTLNDFDEN--TNIVCYPYF---------------------------LDKKKGLEIIKY-----------------YDIIIDCTD---NISTRFLINDLCLLY-------------------------------KKKLIFGSALGLYGQLNVYNLNDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSNCYRCL-KNFNNH-------------------------------------------------------------NEMQNCDEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GILSTVTGIIGLLQANEAIKFSANLKE-----------------------------------------------------------------KTLKPFLSYNSFSNN------KPFEVINMNY----KNKNCI-CSIY|MOCS3/MoeZ
73544459 Leishmania_major_strain_Friedlin VERFGRQMLVEEI-GAAHMGQIRQAHVVCVGAGGLGSTILLYLAASGV----------GRLTIVD-FDDVELSNLHRQVIHTTAA---IGQPKA-LSAKASCLRLFPA--ACIDAVVEA---------------------------LSPANAERLFAT-----------------CDVVVDGTD---NVAARYLINDAAMRC-------------------------------GKPLVSGSAMGWEGQLSVYGYR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGPCYRCLFPQPPPQ-------------------------------------------------------------ETVGSCNDS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVMGPLPGMIGCLQALEVLKVATGVG------------------------------------------------------------------ETLNGRLFLFNGLR-------FSSRVVKLRG----RQPHCAACSAA|
124088215 Paramecium_tetraurelia INRYKRQMILSEI-GLTGQKQIHLAKVLIVGAGGIGAPAIYYLAGAGV----------GTIGLVD-GDSVDVSNLHRQIIHNNYR---QGMNKC-ESAKLQINEFNPL--VNVITYKHH---------------------------LSSANAIEIFQN-----------------YDVILDATD---NPATRYLINDTAIYL-------------------------------NKPLVSGSSVGWEGQITVYGM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGPCYRCLFPQCP---------------------------------------------------------------KTVQNCNEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFGVMPGLIGLIEALQAIKIIIGQ-------------------------------------------------------------------QTLSQKMILIDGLR-------DVYKVVKLRG----QQKDCIACQKQ|
7657339 Homo_sapiens ILRYSRQLVLPEL-GVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGV----------GRLGLVD-YDVVEMSNLARQVLHGEAL---AGQAKA-FSAAASLRRLNSA--VECVPYTQA---------------------------LTPATALDLVRR-----------------YDVVADCSD---NVPTRYLVNDACVLA-------------------------------GRPLVSASALRFEGQITVYHYD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGPCYRCIFPQPPPA-------------------------------------------------------------ETVTNCADG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLGVVTGVLGCLQALEVLKIAAGLG------------------------------------------------------------------PSYSGSLLLFDALR-------GHFRSIRLRS----RRLDCAACGER|
6321903 Saccharomyces_cerevisiae YQRYGRQMIVEETGGVAGQVKLKNTKVLVVGAGGLGCPALPYLAGAGV----------GQIGIVD-NDVVETSNLHRQVLHDSSR---VGMLKC-ESARQYITKLNPH--INVVTYPVR---------------------------LNSSNAFDIFKG-----------------YNYILDCTD---SPLTRYLVSDVAVNL-------------------------------GITVVSASGLGTEGQLTILNFNN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGPCYRCFYPTPPPP-------------------------------------------------------------NAVTSCQEG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVIGPCIGLVGTMMAVETLKLILGIYTN----------------------------------------------------------------ENFSPFLMLYSGFPQ------QSLRTFKMRG----RQEKCLCCGKN|
57117072 Mycobacterium_tuberculosis_H37Rv VARYSRHLIIPDL-GVDGQKRLKNARVLVIGAGGLGAPTLLYLAAAGV----------GTIGIVD-FDVVDESNLQRQVIHGVAD---VGRSKA-QSARDSIVAINPL--IRVRLHELR---------------------------LAPSNAVDLFKQ-----------------YDLILDGTD---NFATRYLVNDAAVLA-------------------------------GKPYVWGSIYRFEGQASVFWEDAPDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGVNYRDLYPEPPPP-------------------------------------------------------------GMVPSCAEG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLGIICASVASVMGTEAIKLITGIG------------------------------------------------------------------ETLLGRLLVYDALE-------MSYRTITIR-----KDPSTPKITEL|
21242767 Xanthomonas_axonopodis_pv_citri_str LERYSRHLRLSQV-GLEGQRRLARARVLLIGAGGLGSPAAFYLAAAGV----------GYLRIAD-DDVVDRSNLQRQILHTEDS---VGTAKV-DSAARRIAALNPR--VDIEAVQTR---------------------------VAADNVEALLQD-----------------VDVVVDGAD---NFPARYLLNDACVKF-------------------------------AKPLVYGAVQQFEGQVSVFDAGRHRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAPCYRCLFPEPPPP-------------------------------------------------------------EFAPSCAEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLGVLPGVIGLLQATEAIKLLLGIG------------------------------------------------------------------DGLTGRLLSFDALA-------MRFRDIRLP-----PDPHCPVCAPG|
37522981 Gloeobacter_violaceus_PCC_7421 LERYSRHLILPEV-GLEGQKKLKAASVLCVGTGGLGAPLTMYLAAAGI----------GRIGLVD-FDVVDASNLQRQIIHGTSW---IGKPKI-DSATDRLQEINPH--LQIDRWPVR---------------------------LSSENALDICRD-----------------YDLIIDGTD---NFPTRYLVNDACVLL-------------------------------GKPNVYGSIFRFEGQSTVFHYE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGPCYRCLYPEPPPP-------------------------------------------------------------GLVPSCAEG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLGILPGVIGVIQATEAVKIILGIG------------------------------------------------------------------TTLKGRLMLYDALN-------MKFRELKLR-----RNPECPVCGDH|
90423526 Rhodopseudomonas_palustris_BisB18 VRRYARHITLPGV-GREGQAKLKNAKVLIIGTGGLGSPISLYLAAAGV----------GVIGLVD-FDVVEMSNLQRQVVHGTNT---IGMPKV-NSAKARLNELNPA--ITVETYDTA---------------------------FSVENALDLVGR-----------------YDVVVDGSD---NFNCRYIVNDACTIL-------------------------------KRPLVYGAIYRFEGQVSVFNHD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGPCYRCLFPQRPPA-------------------------------------------------------------ELSPSCNAG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFGVLPGVIGAIQATEAVKLILGLG------------------------------------------------------------------HSLSGRLVRYDALE-------MKFDEIRFS-----NRANCPDCGSR/
17942693 Escherichia_coli MLRYNRQIILRGF-DFDGQEALKDSRVLIVGLGGLGCAASQYLASAGV----------GNLTLLD-FDTVSLSNLQRQTLHSDAT---VGQPKV-ESARDALTRINPH--IAITPVNAL---------------------------LDDAELAALIAE-----------------HDLVLDCTD---NVAVRNQLNAGCFAA-------------------------------KVPLVSGAAIRMEGQITVFTYQD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEPCYRCLSRLFG---------------------------------------------------------------ENALTCVEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVMAPLIGVIGSLQAMEAIKMLAGYG------------------------------------------------------------------KPASGKIVMYDAMT-------CQFREMKLM-----RNPGCEVCGQ-|
FINAL -HHHHHHHHHH-H--HHHHHHHH---EEEEEE----HHHHHHHHHH-------------EEEEEE---EEEE----EEEEEE---------HHH-HHHHHHHHH------EEEEEEEEE-----------------------------HHHHHHHH---------------------EEEE-------HHHHHHHHHHHHH-----------------------------------EEEEEEEEE--EEEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE--HHHHHHHHHHHHHHHHHH----------------------------------------------------------------------HHH-HHEEEH-------HHHH-HEEEE--------------\archaeal
14601507 Pyrococcus_furiosus_DSM_3638 LNVYSRQLGLL---GVRGQLRLSSSKVAVVGLGGLGNLAAAYLAASGV----------GRLILVD-RDVVEPSNLNRQVLYGKGD---VGRYKA-VAAAERLGELNPE--AEIEPVPEA---------------------------LDPALAEDLARE-----------------ADVIVDGLD---NWMARLWLDAASWRR-------------------------------GKPLVHGAAERMHGQVTTVERG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSSCLACIAPSNPE----------------------------------------------------------------RAGCT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIIAPTVGVVSSLEVLEAIKLLTGVG------------------------------------------------------------------EPLYNRLAVIDLTT-------PRIEVLRLA-----QM-DCRACLSR|ThiF/MoeB/
124027450 Methanosphaera_stadtmanae_DSM_3091 LARYDRQLPLF---GIGGQAKLKNVSVLIAGVGGLGSFEAMYLAALGV----------GRLVLVD-ADYVDITNLNRQVLYWTED---IGKPKP-YPAAEKLRRLNPN--VEVVVVRER---------------------------ITPETASRLVKD-----------------VDVVIDGLD---NWETRLILDEAAYRA-------------------------------GKPYIHAGVYGFQGQVVVVVPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETPCLRCLLPPFLR----------------------------------------------------------------TPERI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAISPVVGIVAGIVVMELVKLVTGIG------------------------------------------------------------------RSNKGRMIIVDTYN-------MEFMNVELK-----PRKGCMCPEPG|MOCS3/MoeZ
91772205 Cenarchaeum_symbiosum KERYAKHIVMKQM-GEEGQKRLLSSRVLCVGAGGLGSPVIQYLAAAGV----------GTLGIVD-DDVVEMSNLQRQVIH-AGN---LGKQKV-WSARQYVERLDPG--INVLAYDMR---------------------------VGPDNVEGLIKD-----------------YDVVVDCSD---NFATRYLLNDACVLQ-------------------------------NKPLFHGSIFMFEGQVMTILPH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGPCYRCIFACSPS--------------------------------------------------------------NDAAKDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVMGILPGVVGTMQATEVVKHLVRLG------------------------------------------------------------------APLIGRMIYYDALG-------MRFDEITVR-----KNPECPICGLT|
55378799 Aeropyrum_pernix_K1 LDRYSRHIIMNDV-GPEGQATLLDTDVLVIGAGGLGAPVLQYLAAAGI----------GRLGIVD-DDVVERSNLQRQVIHKDDD---VGRSKV-DSAAEFVTGLNPD--VTVDRHELR---------------------------LARENATDLVAD-----------------YDIVVDASD---NFATRFLVNDACTLS-------------------------------GTPFSHGAIFQFEGQVTTFS-G----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSPCYRCLFPEAPPE-------------------------------------------------------------GTVPDCATA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLGVLPGTIGCMQATEVVKLAMDYG------------------------------------------------------------------ETLEGRLVAYDAAE-------MSFEEVPIA-----PKPDCPVCGDD|
126465689 Archaeoglobus_fulgidus_DSM_4304 IDRYSRQLPII---GLEGQQKLKKSTVVIVGVGGLGSAASYYLAASGI----------GKLILID-NGLVEESNLQRQILYTVND---IGKPKV-EVAAERLRLLNPY--IEIIPVNEF---------------------------FDENVAMKYFRV-----------------ADVVVDALD---NWEGRLVIDKIAHKL-------------------------------GKPFIHAGVHGFYGQLTVIIPK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTPCLKCIFPKKPS-----------------------------------------------------------------YTVSPL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIIPTTPGVLGVLEANEALKILLGKG------------------------------------------------------------------EIFANKLLVYDGLT-------GMFEVLKLS-----MSPDCPVCTEY|
88601826 Haloarcula_marismortui_ATCC_43049 SSRFERQLPLI---GHEGQKKLENSTILIAGAGGLGSPAATYLALAGI----------GELIIVD-DDRIQESNLNRQFLHAAAS---VGLQKV-YSAEATLGSLAPD--TSVVAYPGR---------------------------IDEGSADRLVAD-----------------ADVVIDALD---NYETRFILHESAWNA-------------------------------DIPFIHGAIEGFSGQMTSILPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSPCLSCLIPAAPP-----------------------------------------------------------------GGKV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVIGAVAGVIGSIQAMEAIKYLTGTG------------------------------------------------------------------SMISGRLFLWDGQA-------GRSEFLTIG-----KRKNCPVCSYK|
126179283 Methanocorpusculum_labreanum_Z RERYRRQVALF---GEEAQERLANARVVIVGAGGLGCPVALYLAAAGI----------GEIRLVD-GDVVDRTNLNRQVLHTERD---VGRAKV-ESAAEKIRAQNPE--IAVAATRAT---------------------------LDEGNAARLAGG-----------------ADLIVDATD---NFAARYILNRVALRN-------------------------------SVPLVHGAVRGFDGQATTIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTACLECIFPVAPP----------------------------------------------------------------GEDVI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVVGTTPGIIGLVQANEAIKYITGTG------------------------------------------------------------------DLLAGRLLVWDGRA-------ATTAILPVE-----RQDDCRACGNG|
116753857 Methanococcus_maripaludis_S2 VARYSRQIPLL---GIEGQERLRRSGVLIAGAGGLGSVSSYYLAAAGV----------GRIRIVD-SDIVDLSNLNRQILHRIPG---V--RKA-VSAEETLRSLNPT--IEVEGVDIC---------------------------ISESSIDDLVDD-----------------IDLIVDAMD---SFEVRYILNSAALKH-------------------------------GLPLVHGAVSGLDGQVTTIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTACLRCVFPRPPP-----------------------------------------------------------------RDAP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVIGATCGIIGSIQATEAIKMLTGVG------------------------------------------------------------------ELLLNRLLIWDGRC-------AQMDEISIE-----RDAGCPDCNGR|
15897242 Pyrobaculum_aerophilum_str_IM2 VERYSRQLIVL---GLGIQQRLNELKILIAGCGALGTAVAELLARLGV----------KELTIVD-ADVVDITNLHRVHLFDEND---VGKPKA-EVCAKKISLINSS--IKINYIIDI---------------------------LDEENVERLISD-----------------KDYVFDALD---SLYYKLLLNDAIVKL-------------------------------GKILIYGGINGEYGSAKLIDPS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTSCLSCFIDYSDQD-------------------------------------------------------------EIGNSCDVI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTTPLIVELTATLQVNLMLNHLRGNP------------------------------------------------------------------D---YSLFYIDSRE-------LKIERINIE-----KNSQCKTCVLN|
16081900 Sulfolobus_tokodaii_str_7 DYKYARQMVLRQF-DKDDIAKIRRARILVVGLGGVGSLIADLLVRSGV----------KKVVLID-RDYVSSSNLYRQTLYSEED---IGDSKV-EAAKRRLQKVNTE--VEVEAINET---------------------------FDATNAEALVSS-----------------VDLVMDGTD---NLTSRLIINDACVKL-------------------------------KRPWVMASAIETYGQVKAVIPE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSCYRCYFTSEP---------------------------------------------------------------FAQPTCAEV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLNSLVTAISSIAFTLAMKILTG--------------------------------------------------------------------KEVDGSIYNLDIWT-------MDLDKIAVD-----RREDCPSCGLH/
FINAL ---HHHHHHHHHH-HHHHHHHHH---EEEEEE----HHHHHHHHHH--------------EEEEE---EEE-----EEEEEEE-------HHHH-HHHHHHHHH------EEEEEEEE------------------------------HHHHHHHHH--------------------EEEE-------HHHHHHHHHHHHH-----------------------------------EEEEEEEEE--EEEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-HHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------EEEEEEH---------HHHHHHH-----------------\CCTBP-associated
118195731 Cenarchaeum_symbiosum MDRYSRQIMLDSI-GYEGQLKLKNARVCVVGVGGIGNPIVTRLAAMGV----------GKLRIVD-RDVIELSNLHRQTMYEESD---VGRVKV-EAAAEKLRRLNSD--VKVEPMAVS---------------------------ISENSAPDVVEG-----------------CDVVVDALD---GVAARYALNRACLTK-------------------------------KIPFVTGAAVGTSGQVFTILPR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETACYNCRFPALGE--------------------------------------------------------------GDVPACSIE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVHPSILSIVGGIEVAETVRVVLGKK------------------------------------------------------------------PDLAGRLLHIDLD---------PLSFSFVDIA---REEQCPVCGPG|ThiF/MoeB/
42557747 uncultured_crenarchaeote LQRYSRQIMLEEI-GFVGLEKLRKAKVCVVGVGGIGNPVVTQLTAMGV----------GKLKIVD-RDIIEISNLHRQHLYTEND---LGKVKV-EAAKERLEKINSS--VEIEALPNS---------------------------VTKYTAESIIRG-----------------YDIVVDALD---SIDARYALNDACIKL-------------------------------NIPLIYAGALGMLGSVCTIIPN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTACLRCIFPALAE--------------------------------------------------------------DDMPTCSTE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVHPSILYLVGGIQVSEAVKIILGEK------------------------------------------------------------------PTLENKLMYVDLN---------DLSLEKISVF---RQEECPSCGTK|MOCS3/MoeZ
57865490 Staphylococcus_epidermidis_RP62A MSRYERQTRFAPF-GEEGQQKLSSSQILIFGAGALGSHIVDQLARMGA----------HHIAIVD-MDIVEISNLHRQTLFDEED-AHTLISKV-EAIKHKVNQININ--VNLTTYDLE---------------------------VTSSNIENLIKNVE---------------PDIIIDGMD---NFKIRYLINEVCHKY-------------------------------QIPWVYGAAVGSKGSVYGI-DH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGPCLKCLLQTIP---------------------------------------------------------------DTGESCAIN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVIPPVISMIASYEVAEAVRYLSGK--------------------------------------------------------------------GFSKQLITIDAFN-------INYKSMNVDAL---KNKDCPVCEKH|
18977661 Pyrococcus_furiosus_DSM_3638 -MRIDFSRHFPII-GIEGQRKLQEKKVAVVGAGALGSWEVYFLKKLGV----------GEIIVVD-RDFVEASDIPR-TIYTEKD---IGRPKV-DVLRDRFG---------VKGYFED---------------------------LNPGTLYLL-DE-----------------ADLILDGTD---NIYTRQVINDYAIKT-------------------------------GKPWIYVGVLATYGNIMPIIPE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTACFRCIMPKLPS--------------------------------------------------------------RPLPTCATA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIMSYVPPLAAAIAVSLATKILLGE--------------------------------------------------------------------EVKSELIFFDTK--------TLEFEKIEIP----RRDDCPACVRK|
16800110 Listeria_innocua_Clip11262 MERYDRQMRVANI-GEIGQEKLLSKTILIVGVGAIGSYAAEICARMGF----------GKLILID-RDYVELSNLQRQSLYTEQD-ALEKQAKA-YAAQKAILLINSE--IEVEYIVDD---------------------------ANMTSLTPFAKK-----------------IDYILDCTD---NFMTRDFLNQFCFIH-------------------------------QIPWIFTSCAGNYANLMPITPP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSACLHCLLGDIPQ--------------------------------------------------------------TNAASCDII---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVDGALIPMVAGMQVSLLTQMILNP-------------------------------------------------------------------DFTANTYYQIDNW--------QLNFQSLAVK----KRPHCTGCSPE|
113937611 Herpetosiphon_aurantiacus_ATCC_2377 SARYSRQTRFAGL-GQAGQQRLAQARVAIVGLGATGSTIAHALLRAGV----------GYLRLID-RDWVEEHNLPRQSLYTEAD-AAQLVPKV-VAAKAHAQRINSA--CDIEALVLD---------------------------LHAGTIDQALAG-----------------VDLIMDGSD---SLETRLLINQWCVRE-------------------------------GKPWIYSGVLGGHGMTANFRPK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-ACWRCVFTTSPEP-------------------------------------------------------------GSMPTCETA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVIGPVVGVIGNLAATEALKLLSGQG------------------------------------------------------------------QA-NPDLYMLDLWA-------WQFEQLPLPT----PRPDCPVCGLR|
15927856 Staphylococcus_aureus_subsp_aureus_ QERYSRQILFKQI-GEIGQSKINQKCALIIGMGALGTHVAEGLVRAGI----------AKLIIVD-RDYIEFSNLQRQTLFTEED-ALKMMPKV-VAAKKHLLALRSD--VDIDGCIAH---------------------------VDYYFLETHGQD-----------------VDVIIDATD---NFETRQLINDFAYKH-------------------------------RIPWIYGGVVQSTYTEAAFIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTPCFNCLVPQLP---------------------------------------------------------------ALNLTCDTV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVIQPAVTMATSLQLRDAMKVLTEQ--------------------------------------------------------------------PIDTKITYGDIWEG------SHYSFGFSKM----QRSDCTTCGDV|
32477346 Rhodopirellula_baltica_SH_1 NDRYVRQAQFAPI-GEAGQAQIESARVAILGCGALGSVASELLVRAGV----------GHIRLID-RDLIEWSNLQRQSLYVESD-AEQALAKA-EAAAGHLRRINSS--VVIEVVVAD---------------------------IHPGNIAENLLD-----------------VDLVIDAAD---NFTLRLLLNDWSLST-------------------------------STPWVHGGCVGANGQV-RFFAG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSPCFRCLVPEVPDP-------------------------------------------------------------GEVATCDTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVIGPATHLIASLQSSEALKFLSGNT------------------------------------------------------------------SAINPRVLSIDLWR-------NQIREVAIDEN---LSSQCPACSGG|
27262352 Heliobacillus_mobilis MERYLKQIRFSGV-GEEGQRRLLSSKVLIAGMGALGTHLANALARAGV----------GHLLLAD-RDYVEKSNLQRQVLYDEDD-VERTMPKA-IAAKKKLQSINSE--INIEAVVTD---------------------------LGWSNLEPLLEG-----------------VDLVVDGSD---NFDLRFLLNDACVRS-------------------------------AIPWIYGGVTGAHGMAMVVLPE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGPCLRCLMPNPPAP-------------------------------------------------------------GTIPTCDTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GILGPAIQMVTAFQSVEALKVLTDRV------------------------------------------------------------------EDLSRGLFSVDLWA-------NRYDLIDLSEA---RRTDCPTCRRR|
77686167 Alkaliphilus_metalliredigenes_QYMF ETRYEKQINFSGI-GSEGQQLLQKASVLIIGCGALGTVVANSLVRTGV----------GHVKIVD-RDFVETGNLHRQILFDEED-AAEGMPKA-EAAKKKLGKMNST--IRIETLVAD---------------------------VNSITISQMISN-----------------VDLIIDCTD---NFKTRYLINDVAFKE-------------------------------NIPWIYGGVIGSSGVLQSFIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETACLRCMMAEPPPT-------------------------------------------------------------GSLPTCDTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVINTITGIIGSLQANEAIKYVTNQV------------------------------------------------------------------EKMKKEMLYLDLWD-------NTVESIEIQ-----TNIDCPCCQKR|
116619877 Solibacter_usitatus_Ellin6076 RDRYSRQILFPGI-GERGQEALLAAHVVIAGCGALGSFHAAALARAGV----------GRLTLID-RDYIEPSNLHRQWLFEEED-AAEGLPKA-AAAARRLGRINSS--IQVHPAIAD---------------------------LTAGNAEELLGE-----------------ADVILDGTD---NFETRYLINDFAVSR-------------------------------GIPWVYGAAVGSYGLTMPVIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSACLRCVYPEPPG--------------------------------------------------------------TGQPTCETA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLNVIVSAVASIQVADTLRLLTGA--------------------------------------------------------------------PLRARITTFDVWK-------GGIRQIDAPD----RDPDCPTCARR|
94969504 Acidobacteria_bacterium_Ellin345 QERYSRQILFHGI-GAEGQQRLAAGRAVIVGCGATGSALASLLARAGV----------GYLRIVD-RDYVEPSNLQRQGLFDEND-AAEALPKA-IAAARKIHAFNSE--ITVEPHVDD---------------------------LTPDNADDLLAN-----------------VQLILDGTD---NFETRYLINDYAVKN-------------------------------AVPWIYSAAVGSYGVAMNILPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETACLACVFPDSPR--------------------------------------------------------------GVVETCDTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GILNTAVNEVASLSATEALKYFVGAR------------------------------------------------------------------EKMRRTLVSTDVWT-------NERSEIRTGG----PKPGCRCCGKR|
87308790 Blastopirellula_marina_DSM_3645 EDRYARQVAYHAI-GAAGQAKLSSSTALIVGLGALGSVIAETLARAGV----------GHLRIVD-RDFLEWNNLQRQVLYTERQ-VRDRLPKA-VAAEQRLRAINSD--VHIEAHVAD---------------------------VDYRNIEELVAG-----------------VDVIIDGTD---NFGVRFLLNDASLKL-------------------------------GVPWIYGGCVGAEGRMMVILPR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETPCFRCLMPEPPPA-------------------------------------------------------------EMTPTCDTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVVAPIVNVIASLEALEAIKLLSGNR------------------------------------------------------------------DAVQRDLVVVDLWE-------NRWRQIKLDNLR--DNADCPACGQQ|
91200473 Candidatus_Kuenenia_stuttgartiensis SDRYVRQELFSAI-GKEGQRKLAHTTVVIIGCGALGCTSANLLVRSGV----------NRVKIID-RDFIEESNLQRQTLFDEED-LWNNLPKA-IAAQKKLQKINSG--IIIEAAVTD---------------------------INPSNIDTNLHN-----------------ANIIIDGTD---NFETRFLINDYCVKN-------------------------------DIPWIYGACIGSTGLTMTIVPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETPCLRCVMQDIPPF-------------------------------------------------------------GNTETCDTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GILSPAASLIASIQVAEALKILTGNG------------------------------------------------------------------ASINRQLLKFDLWK-------NEITRLNINNLR--EINDCKACKNK|
52785401 Bacillus_licheniformis_ATCC_14580 HERYSRQIRYQNI-GQAGQDRIRQSHVLIVGAGALGTSAAEGLVRAGI----------GALSIID-RDYVEWSNLQRQQLYTEKD-AEERLPKA-AAAKERLSEINSG--VELRTYVAD---------------------------GTVETLRPLIEE-----------------ADAVIDATD---NFETRMIINDLAQET-------------------------------GTPWVYGACVSSQGMYMTIIPQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTPCLACLFEDVP---------------------------------------------------------------IGGATCDTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIISPAVQMVSAYQQAEILKILTGQQ------------------------------------------------------------------EALQTAFVTFDLW---------ANTHYRMQIG---RNEKCPSCGET|
42779880 Bacillus_cereus_ATCC_10987 NNRYSRQELFSPI-GEEGQQKIREKHVLIIGAGALGSANAEMFVRAGV----------GTVTIVD-RDYVDWSNLQRQQLYAESD-VKNNLPKA-VAAKKRLEEINSE--VRVEALVQD---------------------------VTAEELEELVTN-----------------VDVMIDATD---NFETRFIVNDIAQKH-------------------------------SIPWIYGACVGSYGLSYTILPS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTPCLSCLLQSIP---------------------------------------------------------------LGGATCDTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIISPAVSLVVSHQVTEALKLLVEDY------------------------------------------------------------------ESLRDGLVSFDVWK-------NEYSCMNVQKL---RKHNCPSCGEN|
30262155 Bacillus_anthracis_str_Ames QERYSRQVLFSGI-GEMGQRKIREKHVLLIGAGALGAANAEALVRMGI----------GKLTIAD-RDYVEWSNLQRQQLYTEED-AKQCKPKA-IAAAEHVRKINSE--VEIVPVVTD---------------------------VTMKEMEELTKE-----------------VDLILDATD---NFDTRLLINDISQKE-------------------------------NIPWIYGGCIGSYGVTYTILPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTPCFRCLM-DHP---------------------------------------------------------------MGGATCDTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIIQPAVQMVVAHQVTEAMKILVDDF------------------------------------------------------------------ETLRGTMLSFDIWN-------NQFLSLKVNKQ---KKSTCPSCGNT|
56419161 Geobacillus_kaustophilus_HTA426 NERYSRQQLFAPI-GEEGQKKIRGKHVVLVGAGALGTGNAEALVRAGI----------GKLTIID-RDYVEWSNLQRQQLYSEAD-AKERLPKA-IAAKRRLEQINSE--VEIEAIVGD---------------------------AGPEELETIALKQR---------------PDLWIDATD---NFDTRLVINDVAYKY-------------------------------NIPWIYGACVGSYGLSCAFIPN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTPCLYCLLETVP---------------------------------------------------------------QGGLTCDTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIISPAVQMVVSYQMAEALKILVEDW------------------------------------------------------------------SALRGKLVSFDLWT-------NEYASIRIDGV---KKDGCPTCGRH/
FINAL --HHHHHHEE-----HHHHHHHH--EEEEEEE----HHHHHHHHHH-------------EEEEE----EEE------EEEE----------HHH-HHHHHHHHH------EEEEEEEE------------------------------HHHHHHHHH--------------------EEEE--------HHHHHHHHHHHH-----------------------------------EEEEEEEEE---EEEEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE-HHHHHHHHHHHHHHHHH----------------------------------------------------------------------HHHHHHHHHHHHH-------HHHHHHH------------------\HesA
119486782 Lyngbya_sp_PCC_8106 LERYRRQMQLPDF-GEAGQAKLKASTALVSGVGGLGGTVALYLAVAGI----------GKLILVR-GGDLRLDDMNRQILMTHDW---VGQPRV-LKAKETLSQINPD--VEIEAIPEF---------------------------ITSDNVDGLVKR-----------------SDLALSCAH---NFDERDLLNAACVLW-------------------------------DKPMIEAAMSGMEAYLSTIIPR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTPCLSCIFPEKP-----------------------------------------------------------------NWDRWGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLGAVSGTLACLTALEAVKLITGLG------------------------------------------------------------------ETLKGQLLTMDLGS-------AKFNKLRAY-----HDPNCQICGQG|
67154932 Azotobacter_vinelandii_AvOP RERYSRQLRIEGF-GEEGQLRLKGATVLVSRVGGVGGTAAMNLVRAGV----------GRLILAH-GGKVVPEYLNRWQLITPDD---LGRPCA-QVWAEKLGQIDAD--VEIVTVDEY---------------------------INGENVADLVSR-----------------ADLVVDGAP---LFEERYLMNDEAMRQ-------------------------------GKPLCMGAMFGMEGYASTFIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESACLRCVFPEKP---------------------------------------------------------------EYWTDMKVF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAIGPGPAIVGTTIAMEAIKVLTGFG------------------------------------------------------------------QPLKNILWFFDLES-------NTTRYLEIE-----RVKDCPACGAS|
125995244 Gloeothece_sp_KO68DGA LERYSRQIQLPDF-GEEGQKRLKDSTAVVTGVGGLGGTVALYLAVAGV----------GKLILVR-GGELRLDDLNRQILMTNSW---VGQPRV-YKAKETLLNLNPD--IRVEAVNEF---------------------------VTAENIDALVQQ-----------------ADIAFDCAF---DFKERNLLNTACVRW-------------------------------GVPMVEAAMSGMDAYLTTIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETPCLSCIFPEKP-----------------------------------------------------------------EWDRWGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLGAVSGSLACLAALEGIKFLTGVG------------------------------------------------------------------ETLTGQLLTMDLGT-------ATFAKRRPY-----HDPECPVCGNF|
67922899 Crocosphaera_watsonii_WH_8501 RERYSRQIQLPGF-GEEGQKRLKDSTAVVTGVGGLGGTVALYLAVAGV----------GKIILVR-GGDLRLDDLNRQILMTNSW---VGQPRV-YKARETLLNINPD--IEVEAVSEF---------------------------VTAENIDALVQQ-----------------ANIAFDCAF---DFKERHLLNQACVRW-------------------------------GVPMVEAAMSGMDAYLTTVIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETPCLSCIFPETP-----------------------------------------------------------------EWDRWGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLGAVSGSLACLAALEGIKLLTGLG------------------------------------------------------------------EPLTGQLLTMDLGT-------ATFAKRRPY-----HDPNCPVCGNF|
113477563 Trichodesmium_erythraeum_IMS101 LERYSRQMMLPGF-GEEAQQRLKSTTAVVTGVGGLGGTVALYLAVAGI----------GKLILVR-GGELRLDDMNRQILMTDDW---VGKVRV-DKAKETLSAINPD--IEIEAVPEY---------------------------VTAENVDPLVQS-----------------ADIAIDCAH---NFDERNLLNAACVRW-------------------------------RKPMVEAAMNSMEAYLTTIDPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTPCLSCLFPEKP-----------------------------------------------------------------QWDRRGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLGIVSGTLACLAASEAIKQITGFS------------------------------------------------------------------KPLWSQLLTMNLDS-------MEFAKLRPY-----HDPNCQVCGSL|
119509267 Nodularia_spumigena_CCY9414 LERYSRQMMLPNF-GELAQKRLKSATVLVTGVGGLGGTAALYLAVAGV----------GRLILVR-GGDLRLDDMNRQILMTDDW---VGKPRV-FKAKETLEAINPD--IKVDVVHDY---------------------------VTAENVDSLVQS-----------------ADMALDCAH---NFTERDLLNAACVRW-------------------------------RKPMVEAAMDGMEAYLTTIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTPCLSCLFPEKP-----------------------------------------------------------------DWDRRAF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVLGAVSGTLACLTALEAIKLITGFS------------------------------------------------------------------QPLLSQLLTIDLNR-------MEFAKRRSQ-----RDRACPVCGNT|
75910142 Anabaena_variabilis_ATCC_29413 LERYSRQMMLPNF-GEAAQKRLKSATVLVTGVGGLGGTAALYLAVAGV----------GRLILVR-GGDLRLDDMNRQVLMTDDW---VGKPRV-FKAKETLQAINPD--IQIETIHDY---------------------------VTSDNVDSLVQS-----------------ADMALDCAH---NFTERDLLNSACVRW-------------------------------RKPMVEAAMDGMEAYLTTIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTPCLSCIFPEKP-----------------------------------------------------------------EWDRRGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVLGAVSGTLACLTALEAIKLITGFS------------------------------------------------------------------QPLLSQLLTIDLNR-------MEFAKRRLY-----RDRSCPVCGND|
111226133 Frankia_alni_ACN14a SRRFDRQVTIPGF-GVAAQRRLSQATVLVAGVGGVGGAAATYLAAAGV----------GRLILIH-PGDLAEPDLNRQTLMRPER---VGEPRV-FCAADTLRAHHPG--VEIVAVDRD---------------------------LTDPAVPGLIAE-----------------ADVVVDARH---NSPERYLINRLCVQA-------------------------------AVPLVVAAMNATEAYLMVVRPG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPCLRCVFGEGD----------------------------------------------------------------PAWEPLGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVLGAVAGTVGCLAATEALKIAGGFG------------------------------------------------------------------ESAVGRLVHLDLWD-------VDLRTPRTR-----RDPACPDCGPG/
FINAL -----------HH-HHHHH------EEEEEEE--HHHHHHHHHHHHH-----------EEEEEEE-EE-----HHHHHH----------HHHHH-HHHHH----------EEEEEEE----------------------------------EE----------------------EEEEEE------HHHHHHHHHHHHH-------------------------------------EEEEEEEEE-----EEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHH----------------------------------------------------------------------------EEEEE---------------EEEE------------HHHH\MJ0693-
150399309 Methanopyrus_kandleri_AV19 ----------MDI-KLLEDKLNSKGTVSVIGCGRLGVRVIMDILEVHRGGF-------KKIEVFD-AAKIDMNDVIHRKYGGK-----VGEYKV-SFIKDFFPEK-----IDAVFEDIS---------------------------KENLEKISGNI------------------VLVVFAGGD---TLNLRKKIIEYCKTT---------------------------------KKICIGTNGVFGLNCNVKVG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAKY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENGPVEFLKMEE-------------------------------------------------------------------------EGHLVVGTG-------------KFIKD----MEPITPYSLDK|like
134045393 Methanococcus_vannielii_SB ----------MDI-KALEDKLKPNGTVSIIGCGRLGIRIAMNILEVHRGGF-------EKLQIFD-AAKIDQNDVVHRKHGAK-----IGEYKV-NFLKEFFPER-----IEAFFEDIT---------------------------EKNIEKITGEV------------------VLIVFAGGD---TLPIRKKIVEYCKNT---------------------------------GKVAIGTNGVFGFNPLIKIG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKGPVEFLEMGT-------------------------------------------------------------------------KGHLVVGTG-------------KFIKD----MEPITPYTLDE|
159905813 Methanococcus_maripaludis_S2 ----------MDI-KALEDNLKPKGTVSIIGCGRLGFRIAMDFLEVHRGGF-------EKLQIFD-AARIDQNDVVHRKQGAK-----LGEYKV-NFLKEFFSER-----IEAFFEDIT---------------------------EKNIEKITGEV------------------VLIVFAGGD---TLPIRKKIVEYCKNT---------------------------------GRVAIGTNGVFGFNSKIKIG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DATT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKGPVEFLKMET-------------------------------------------------------------------------KGHLVVGTG-------------KFIKD----MEPITPYTLDE|
148642637 Methanocaldococcus_jannaschii_DSM_2 -----------MI-QEIEDSRIPKGRIDLIGFGRLGLRIGIHLIQVHRGGP-------KEIGVFD-GQKIDGGDVIFTMKGAN-----IGEYKA-DFLNKLCTHDENFRKIISVCEDIT---------------------------PDNLDLIKGDV------------------VAIQIAGGN---TIPIAAKIIKHAHER---------------------------------GAKTISTAGIFGFGDETIEV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDISEFE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNPAVDELRKEGIT-----------------------------------------------------------------------ENHLIVTTN-------------KLLRD----HEPITPYTLDE|
124486554 Methanobrevibacter_smithii_ATCC_350 ----------MKI-TELEQKKVPHGEVVLIGLGRLGLRTALNLMHVNRGGP-------VRITVYD-GQKISADDLIFRMWGGE-----IGEYKT-DFLKRLAGPGYSRE-IISVPEYIS---------------------------EENLSLITGGDV-----------------ACVEIAGGD---TLPTTGAIIRHAQSL---------------------------------GMKTISTMGVFGISGDNVYA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPLEEANT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNPIVAAMLEYGI------------------------------------------------------------------------SHHMLVGTG-------------KLIRD----WEPVTPYIMDK|
15679158 Methanospirillum_hungatei_JF_1 ----------LEI-SELEGKKAPRGEVTLVGAGRLGLRTALNLMQIHRGGP-------ERINVID-GQRVSADDLIFRLMGAT-----PGEYKV-KFIESLATPGFSRT-VRGIPEYID---------------------------RDNLHLLRGDV------------------VCVEIAGGD---TLPVTAEIIKYAQKR---------------------------------GSATISTMGVFGIGEEEVNA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISIEEADP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNPIVEYLLDEGV------------------------------------------------------------------------TDHLLVGTG-------------KLIRD----WEPVTPYVLDR/
FINAL HHHHHHHHH-------HHHHHHH--EEEEEEE----HHHHHHHHHH--------------EEEEE---EEE---HHHHHHHHHH------HHHHHHHHHHHHH----E--EEEEEEEE------------------------------HHHHHHHH---------------------EEEEE------HHHHHHHHHHHHHHH--------------------------------EEEEEEEEE----EEEEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHH---- ------------------------------ ------ \ThiS+ThiF
118746007 Geobacter_lovleyi_SZ ALMAARHTP-------GIHARLKQACVGIAGAGGLGSAVAVALARIGV----------GRLIIAD-FDLVEPSNLNRQQYFIDQI----GLYKVAALTQNLQRINPYI--SVEPHQAL----------------------------LGPDNIPQLFAP-----------------CSVVVEAFD---RADMKAMLVDTVLSCLPG----------------------------CCVVAASGVAGYDDNNSITTRR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISSRLYLVGDGV------------------------------------------------------------------SEAQPGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLMAPRVAIAAGHQANQVVRIILGERS---------------------------------------------------------------------------------------------------------------|
95930339 Desulfuromonas_acetoxidans_DSM_684 AFLVARHTP-------EVHEPLKQATIGIAGAGGLGSSIATALVRAGI----------GRIIIAD-YDVVEPSNLNRQQFFIDQI----GMNKVDALKDNLKRINPFM--TVDAQHRF----------------------------LTTQNLTDLFAE-----------------VDILVEAVD---CAETKAMITGQWLRTYPN----------------------------TPLVAGSGMAGYGPGNTIRTRR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AMGQLYLCGDGT------------------------------------------------------------------SEVDAGH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLMAPRVGIAAHHQANVVIRLLLGLDPVEEDS----------------------------------------------------------------------------------------------------------|
86152451 Campylobacter_jejuni_subsp_jejuni_H AMMRARHTP-------KLHDKLKNGRVAVCGLGGLGSHIAINLARSGV----------GYLKLID-FDVIEPSNLNRQAYRVSDL----GKFKTEALKEQISEINPYI--SVEICTLK----------------------------IDEDSLKSLFKD-----------------IDIVCEAFD---SAIAKAMIAQNFHRFYKD----------------------------SVLICASGLAGYGDSNSIQTRK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAKNFYVCGDLV------------------------------------------------------------------NGAKLGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLMAPRVNICAGHQSNLVLELLANKE----------------------------------------------------------------------------------------------------------------|
28211400 Clostridium_tetani_E88 IQLVARHTP-------KVYEELRKASVAIAGLGGLGSTAALSLARIGI----------GKLILVD-YDVVEPSNLNRQQYFIKHI----GMKKTEAIKDIISQCNPFV--DIQTIDAY----------------------------VDEKNMENIFKD-----------------ADIIIEAFD---NAETKALITNTVLTTMKD----------------------------KKIITASGLAGYEDCNLIRSKK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------INDRFYIVGDGQ------------------------------------------------------------------AEAKSGR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLMTPRVSVAANHQANLVLELILKENII--------------------------------------------------------------------------------------------------------------|
77683437 Alkaliphilus_metalliredigenes_QYMF VLLTSRHTP-------GVHKKIKKASIGIAGLGGLGSNIAVSLARMGI----------GKLLLVD-FDVVEPSNLNRQQYFIRHI----GMLKTEALQQLIHEINPFV--EVEVINIY----------------------------LDQTNIEDCFKN-----------------MDVIVEAFD---NPTSKSTLVNTVLEKMKE----------------------------KPMVAASGMAGYFSNNSIKTKR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITKKFYLIGDGV------------------------------------------------------------------SAAKPGC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLMAPRVAIAANHQANTVVRILLGEEEEV-------------------------------------------------------------------------------------------------------------|
119025108 Bifidobacterium_adolescentis_ATCC_1 AALLDRHTA-------ATQDKLDAAHVAICGCGGLGSTIAVALTRIGV----------GHLHLID-FDRVDMTNLNRQQYFLKDL----GQYKTEALRSNLRQINPFT--DITIDTVK----------------------------VTDENVPTLFEN-----------------EDIICEAFD---VPENKTMLVNAVLENLPG----------------------------KKLVSASGMAGFRSSNLVSTRR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSKNFYFCGDGE------------------------------------------------------------------TAPVPGA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLMAPRVGVVACHEANMITRLILGEEDDA-------------------------------------------------------------------------------------------------------------|
34763553 Fusobacterium_nucleatum_subsp_vince EDLLKRNVK-------GISEKLKKAKVCILGLGGLGSNVAVLLARAGI----------GYLKLID-FDVVEASNLNRQQYRISHI----DMKKTEAMKTIIREINPFV--EVDILDIK----------------------------VDRKNIYSIVGD-----------------IEIVVEAFD---KAEIKAMLMEELLTNTN-----------------------------KIVVSASGMAGLGSANEIVTKK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKDNFYLVGDNY------------------------------------------------------------------SDYEEYL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIMSTRVMICAAHQANVVLRLILGEKGGE-------------------------------------------------------------------------------------------------------------|
78356600 Desulfovibrio_desulfuricans_G20 RGLGSHLKE-------HQLELLSGAVVGIAGAGGLGSNCAAMLVRSGI----------RNLVLAD-HDHVEPSNLNRQWFTPQQV----GKSKVRALADNLYALEPEL--VLSVHQVR----------------------------IDRTLLHDLFGS-----------------CSVVVEAVD---DAATKSMIVSYCMEHG------------------------------IFFVSASGMGGWGGP-GMQVRG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRNAGVVVGDMQ------------------------------------------------------------------TAVVPGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPMAPRVQMAAAMQADAVLCRILGPCVVTADCIREQE-----------------------------------------------------------------------------------------------------|
85859822 Syntrophus_aciditrophicus_SB QHLIAKIGR-------ENFERVRRTMVGIAGAGGLGSNCAAHLVRVGF----------RKLKLVD-FDVVETGNLDRQFYFADQV----GMYKVEALRQNLLRISSDL--ELAVEVRK----------------------------IEQTSVRGLFSN-----------------CPIVAECLD---KAEDKSMLVSELLPLD------------------------------KFIVAVSGIGGCGSSDDIRVHP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKNFVLIGDLH------------------------------------------------------------------SDIAF-R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PALSPKVNIVAAKQADTILERVLSHPVVS-------------------------------------------------------------------------------------------------------------|
98663022 Pelotomaculum_thermopropionicum_SI TALAGILGK-------EKLAAIQRLKVGIAGAGGLGSNCAAFLVRSGF----------KRFRIVD-FDVVESGNLNRQFYFAAQV----GKSKVAALKENLLLINPGL--EIEALPEK----------------------------IDEGNVTALFSC-----------------CDVVVEALD---RAEYKRMLVEACLGTG------------------------------KLLVAASGLAGWGRSDGIKIHR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKENFYLVGDLV------------------------------------------------------------------SEAGPGC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAMAPGVSVAAAKQADVILAYFLENLAAGRDCCG--------------------------------------------------------------------------------------------------------/
FINAL HHHHHHHHHHH---HHHHHHHHH---EEEEE-----HHHHHHHHHH-------------EEEEEE---EEE-----EEEE----------HHHH-HHHHHHHHH------EEEEEEE-------------------------------HHHHHHHHH--------------------EEEEE------HHHHHHHHHHHHH-----------------------------------EEEEEEEEE--EEEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E--HHHHHHHHHHHHHHHHHH------------------------------------------------------------------------HHHEEEEEHHH-------HHHEEEE------------------\AOR-associated
114567221 Syntrophomonas_wolfei_subsp_wolfei PQRYQRNAKSI---TREEQCRLFQSRVAVIGCGGLGGYLLEELARLGI----------ASISAWD-YDSFAEHNLNRQLLSDMDT---IGLSKV-ETAAKRVQAINPA--VKFQAFNRP---------------------------FAAGEGEDLLAG-----------------HQVVVDALD---SIPVRKMLAAVCQRL-------------------------------SLPLVHGAIAGWCGQVCTQFPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDSLETIYRNSN----------------------------------------------------------------QEQGVESKQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLAFAPAVVASLQVAEVVKILLGRG------------------------------------------------------------------ELLRKRILLFNLLD-------MEFEVLDL-----------------|
95929923 Desulfuromonas_acetoxidans_DSM_684 PARYQRNRNML---NCRDQLALFSSHIAVVGCGGLGGYIIEELARIGV----------GHLTVID-PDFFEEHNLNRQILSTPAN---LGHDKV-AVAAHRVAEINPA--VTVTPVVKA---------------------------LSRTNGCGLLAG-----------------AQVVVDGLD---NIDTRLELSEVCESL-------------------------------ELPLVHGAIAGWYGHVTSQMPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DKSLDTLYGQKQ----------------------------------------------------------------RPKGIEGSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNPSFTPSLIASVQVAEVIKILLNHG------------------------------------------------------------------EPLRHRLFTIDLLD-------MECIETPL-----------------|
78222261 Geobacter_metallireducens_GS_15 PARYQRNRQTI---TVGNQLRLCRSCAVIIGSGGLGGYLIEELARLGV----------GNLVVVD-PDIFEEHNLNRQILSSPAF---LGHPKV-EVAAARVGEINPA--VTVTPLQLS---------------------------FSRENGQGILAG-----------------SDVVMDGLD---SIATRIELAECCRGL-------------------------------SIPLVHGAIGGWYGQVASQLPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDIVPSLFGNWS----------------------------------------------------------------EPKGVESQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNPSFTPAVVASLQVAEACKILLGEG------------------------------------------------------------------ESLRHRMIYVNLLH-------MEFDEVLLE-----PPLAAVGE---|
77917868 Pelobacter_carbinolicus_DSM_2380 PARYQRNRNML---NLDDQLKLYNSKVAVIGCGGLGGYIIEELARLGV----------GTIVAVD-PDVFEEHNMNRQLLATPDF---LGIKKV-AAAARRVDRVNPA--VELLPVGLA---------------------------FGLDNGTRILEN-----------------CHVAVDALD---SIAVRLELAEICQQL-------------------------------SIPLVHGAIAGWYGFLMTQFPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERTLQKFFAHNS----------------------------------------------------------------QESGLEKHL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNPSFTPAVVASLEVAEVCKVLLNQG------------------------------------------------------------------TPTRRRCLSIDLYD-------MEFVEIEC-----------------|
110598940 Geobacter_sp_FRC_32 PARYQRNRQAI---NIAQQLTLFQGVVAVAGCGGLGGYIIEELARLGV----------GTIVAID-PDVFEEHNLNRQLLSSPAR---LGEAKV-ESAAARVAEINPA--VALVPVQIA---------------------------YAPKNAAQLFHG-----------------VQVVVDALD---SVSTRLALSDSCDSL-------------------------------GLPLVHGAIGGWFGQVVTQFPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGTIRQLYSRWV----------------------------------------------------------------EGKGLEQRL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNPSFTPALVASIEVAEVCKILLGAG------------------------------------------------------------------NTLRNRKLSINLLD-------MEFEEIRLD-----GQDKAVGQ---|
78357502 Desulfovibrio_desulfuricans_G20 PERYARNTKQF---SLEDQRALLLSRVLLVGLGGLGGHVLDMLVRLGV----------GHITAAD-GDVFEPSNLNRQLLSSMSR---VGTSKA-QAARDHARNTNPA--TELTVVDHY---------------------------VDALSLPPLMQQ-----------------CHLVIDALG---GLQSRLMLQKAAQNA-------------------------------GVPLVTAAVGGLTGYVATVLPD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTGPAELLGSGG----------------------------------------------------------------TGEPVEDTL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPAPVVACAAALQCTEAAKIL--TG------------------------------------------------------------------KPPSRGVLFFDLND-------RTFQTVML-----------------/
FINAL --HHHHHHHHHHHHHHHHHHHHH---EEEEEE---HHHHHHHHHHH-------------EEEEEE----EEE---HHHHHHHH-------HHHH-HHHHHHHHH--------EEEEE---------------------------------HHHHHH---------------------EEEEE-----HHHHHHHHHHHHH-----------------------------------EEEEE----------EEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHH------------------------------------------------------------------------------EEEEEE------------------------------------\YgdL-like
59801349 Neisseria_gonorrhoeae_FA_1090 SRRFGGIARLY---GDSALTHFSQAHVCVVGVGGVGSWAVEALARTGI----------GRLTLID-LDNVAESNANRQLHALTGD---FGKAKV-TALRERITQINPQ--CEVFEIEDF---------------------------VTEDNLPEYFGKG----------------FDFVIDAID---QVRVKAAMAAYFVER-------------------------------KQPFVLSGGAGGQKNPALIQTA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLSRVTHD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLANLRYTLRKRYGFSRDTKEKM-------------------------------------------------------------------RVPCVYSTE---------NIMPPQSGA----ASADAAPQGLS|
91212182 Escherichia_coli_UTI89 RQRFGGTARLY---GEKALQLFADAHICVVGIGGVGSWAAEALARTGI----------GAITLID-MDDVCVTNTNRQIHALRDN---VGLAKA-EVMAERIRQINPE--CRVTVVDDF---------------------------VTPDNVAQYMNAG----------------YSYVIDAID---SVRPKAALIAYCRRN-------------------------------KIPLVTTGGAGGQIDPTQIQVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLAKTIQD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLAAKLRERLKSDFGVVKNSKGKL-------------------------------------------------------------------GVDCVFSTEA--------LVYPQSDGT----VAMKATAEGPK|
28899142 Vibrio_parahaemolyticus_RIMD_221063 NQRFGGTRRLY---GNSEVDILRAAHVCVIGIGGVGSWAVEALARTGI----------GELTLID-MDDVCVTNINRQIHAMTGT---VGQSKI-EVMAERVKLINPE--CKVNLIDDF---------------------------ITPDNQHEYLSKE----------------FDYVLDAID---SVKAKASLLAYCRSN-------------------------------KIKVITTGGAGGQVDPTQIMVA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTKTIQD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLAKKIKDTLRRHHNFPKNPARKF-------------------------------------------------------------------GIDCVFSTEQ--------LKYPQADGS----VGVKSTAEGPK|
29349047 Bacteroides_thetaiotaomicron NNWQQRTELLL---GEEKMKRIRASHVLVVGLGGVGAYAAEMLCRAGV----------GRMTIVD-ADTVQPANMNRQLPAMHST---LGMPKA-EVLAARYKDINPD--IELTVLPVY---------------------------LKDENIPELLDSAK---------------FDFIVDAID---TISPKCFLIYEAMKR-------------------------------HIKIVSSMGAGAKSDITQICFA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLWDTYHC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLSKAVRKRLQKMGVKR--------------------------------------------------------------------------KLPVVFSTEQ--------ADPKAVLLT----DERNKKSTCGT|
49483873 Staphylococcus_aureus KHQFSRNELAI---GHQGLDLLKQQTVVILGVGGVGSFAAEALARTNI----------GHIILID-KDDVDITNVNRQLHALTTT---VGQSKV-SLMEERIKLINPD--CKVTPLHMF---------------------------YTEETYEEIFDNYD---------------IDYFVDASD---TIMYKVHLMKECLDR-------------------------------GIKVISSMGAANKTDPTRFTIS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DISKTHTD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMAKIIRQKLKKLGIRK--------------------------------------------------------------------------GIPVVFSDES--------PIVIREDVK----DVGDKNAINRK|
78224428 Geobacter_metallireducens_GS_15 LHRFSRTEILI---GPEKLQRLRESTVAIFGLGGVGSFAAEALCRAGV----------GRLVLVD-FDDICLTNVNRQLHAMDGT---VGKAKV-QVMAERLRLINPD--ADIVPHKDF---------------------------YEAGNS-DFLLSGG---------------YNYVVDAID---HITSKLHLIRSCRER-------------------------------ELRIISSMGAANKLDPTKIRVA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DISKTSVC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLARVVRKQLRRQGIKS--------------------------------------------------------------------------GVTVVYSTEE--------PREQAIADA----GRSNCICPNKE|
83590511 Moorella_thermoacetica_ATCC_39073 ESFWTRTEMLI---GAAGRKRLAAARVAVIGTGGVGSFAVEGLARAGV----------GYLELVD-PDVVKPSNLNRQLPALGST---LGQPKV-AVLAARCRDINPE--ATIIPRQEA---------------------------YSPATSLKFVRPD----------------LDFLVDAID---SVKAKIDLLATAVTA-------------------------------GRPIVSSMGAGNRLDPTLLRVA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DISATRGC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLARAVRRGLRARGIAG--------------------------------------------------------------------------GLTVVYSEEP--------PLEVRTKPQ----LPGERQPPGSM|
42527750 Treponema_denticola_ATCC_35405 MSFLSRFEPLL---GSENLKKIEDARIAVFGLGGVGSYTAEALARSGVARNGA-----GQLILID-GDEIEESNINRQLYALYST---IGKAKT-EIAMERIADINPA--CKIEAVNSF---------------------------ILPDNFYKILGEDFFKR------------VDFIVDAVD---TIALKIFLAAEAEKN-------------------------------EVPIISAMGCGNRLN-ADFEFA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIYKTSVC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCKVMRTELKKRNVK---------------------------------------------------------------------------YLKVLYSKTE--------TVKQNPPAS----AAWVPSIAGLL|
19704060 Fusobacterium_nucleatum -MFLQRTELLI---GSDNIEKLKNSNVIVFGLGGVGGATVEALVRAGI----------GNLSIVD-FDTIDKTNLNRQIITTQSV---IGKPKV-DVAKDRILSINPN--INLTIYNEK---------------------------FLKEKIDLFFKDKK---------------YDYIVDAID---LVTAKLDLIEFATNS-------------------------------KIPIISCMGTGNKLNPAQFKVV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DINKTSVC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLAKIIRKELKKRRIN---------------------------------------------------------------------------KLKVVYSDET--------PRKPLNLDG----DEKAKNVGSIS|
15611759 Helicobacter_pylori_J99 IDRFTRIRWLF---KND-FEKIRQQRVLICGVGGVGGFALDSLYRVGI----------GQITIID-KDMFDVTNQNRQIGS--ER---IGESKV-LVLQDLYKGIQALN-CRI-----------------------------------DEAFLNSFNFRD---------------YDYILDCMD---DLPIKTSLAIKCQNF------------------------------AYGKFISSMGSAKRLNPKHIQVG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVWESYGD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFGRKFRDFLKKRRFKG--------------------------------------------------------------------------DFKVVFSPEV--------PHCIELGSF----NAVTASFGLQI/
FINAL -HHHHHHHHHH---HHHHHHHHH--EEEEEEE---HHHHHHHHHHH-------------EEEEEE---EEEE---HHHHHHH--------HHHH-HHHHHHHHH-------EEEEEEEE-------------------------------HHHHH----------------------EEEEE------HHHHHHHHHHHHH----------------------------------EEEEE----------EEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHH--------------------------------------------------------------------------------EEEEEE-----------------------------------\YKL027W
19114114 Schizosaccharomyces_pombe_972h_ REQLARNYAFF---GEDGMERLRNSFVIVVGCGGVGSWVINMLARSGV----------QKIRIVD-FDQVSLSSLNRHSIATLQD---VGTPKT-LAIKKAIKKFAPW--IEVDARNAL---------------------------FNPDSADDLLSGN----------------PDFVIDAID---NIQTKVDLLSYCYNH-------------------------------KLPVIASTGSACKSDPTRVNIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DISATSED---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSRATRRRLRLLGIME--------------------------------------------------------------------------GIPVVFSTEKPDP----RKASLLPLSE-----EEFEKGDVDE|
42568166 Arabidopsis_thaliana SEHLTRNIQFF---GLESQHKVTGSYVVVIGLGGVGSHAASMLLRSGV----------GKLLLVD-FDQVSLSSLNRHAVATRAD---VGIPKA-MCLKKHFSSIFPE--CHIEAKVML---------------------------YDSSSEEEILSGK----------------PDFVLDCID---NIDTKVGLLAACVKR-------------------------------GLKVLSATGAGARADPTRIRVA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIRESTID---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSRSVRHRLRRKHGIEG-------------------------------------------------------------------------GIPVVFSLEK-------PKAKLLPFEG-----TNGEDENPLD|
115467390 Oryza_sativa_japonica_cultivar_grou SEQLTRNIQFF---GMESQKKVTGSFVVVIGLGGVGSHAASMLLRSGV----------GRLLLVD-FDQVSLSSLNRHAVATRDD---VGTPKA-LCLKKHFSMIYPE--CQIEAKVQL---------------------------YDPSCEDEILSGQ----------------PDFVLDCID---NIDTKVALLAACVRR-------------------------------GLRVLSAMGAGARADPTRIRVA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLRESSND---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSRAVRYRLKKDHGIEG-------------------------------------------------------------------------GIPVVFSLEK-------PKAKLLPFQ-------ASKEEETPS|
58262438 Cryptococcus_neoformans_var_neoform REQLTRNYNFL---GEESMGLVRKSYVVVVGCGGVGSWCALMLLRSGV----------GRILLID-FDLATLSSLNRHACATLED---VGTPKV-IAMQKYLKKIAPW--ARIEVEIGL---------------------------WRKGEGEKWLEG-----------------ADWVVDAID---NIDTKADLLAHCHEQ-------------------------------GIKVFSSMGSGAKKDPTRVQIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DISSTYED---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLARSVRRRLRMAGISS--------------------------------------------------------------------------GIPVVYSTETP------SEVKLLPLDE-----EEFKRGAVKE|
85074755 Neurospora_crassa_OR74A LEQLARNRVFL---GDEGLAKLRNSFVVIVGCGGVGSHAATTLARSGV----------SKLRLID-FDQVTLSSLNRHAVATLAD---VGIPKV-QCLQRRLIAITPW--VRFDLRLQK---------------------------FDGSVAPELLGAWEKDGQM----------PDFVIDAID---NIDSKVELLKYCYDN-------------------------------NLPVISSMGAGTKSDPTRIMVG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIGTSTDD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLSRATRRRLKLLGVTS--------------------------------------------------------------------------GIPVVYSTEKMGE----GKAALLPLPE-----EEFKKGDVGD|
6322825 Saccharomyces_cerevisiae RQSLKNNVEFL---GEDTIEKLSNQYVVVVGAGGVGSWVVNSLVRSGC----------RKIRVVD-FDQVSLSSLNRHSCAILND---VGTPKV-ECLRRHMREIAPW--CEIDPINEL---------------------------WTLQNGERLTLGNGT--------------PDFIVDCID---NIDTKVDLLEFAYNH-------------------------------GIKVISSMGASAKSDPTKLNVG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLATTEED---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLARVVRRKLKKRGILS--------------------------------------------------------------------------GIPVVFSAEKPDP----KKAKLLPLPD-----EEYERGKVDE|
118400480 Tetrahymena_thermophila_SB210 KEQLVRNIQFF---GEEGQKKIQDSYIIIFGVGGVGSHVAASLARSGV----------AHLKIVD-FDQVSLSSLNRHAFATHAD---VGRSKC-ECVKDYIKRIVPH--TRVDIVEDY---------------------------VTKNNVETFFKDLAEDGKTIIK-------PTYVVDCID---NIDAKVSLLAYCKLN-------------------------------GIKVISSMGAGMKADPTRIQIR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DISETNYD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLSRAVRTKLKKYKVHD--------------------------------------------------------------------------GIKVVLSVER-------SERELLPL-------KEHQESNPDE|
66827717 Dictyostelium_discoideum_AX4 NEQMDRTKLYY---GEEGFEKIRESFVVVVGLGGVGGAAAHVLLRSGV----------KKLRLID-PDLVTLSSLNRNALATRND---VGRSKV-EVMKQHFHDICPE--VEVEAIQTF---------------------------FTGELAPKLLHGK----------------PDYVLDCID---NTQTKVELLTYCKRE-------------------------------NLRVISSFGAGSSSDPTKVHIS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DISYTFGC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFGREVRRLLKLNGIQD--------------------------------------------------------------------------GILCVYSTEV-------HRKKLIPL-------TEDELKLLNE|
67482677 Entamoeba_histolytica_HM_1IMSS ---MNGICTML---SQEQRDSLKSKHILIVGLGGVGSYTAEILARCGI----------GQLTIVD-ADTISVSNINRQLPAIPST---VGQSKV-GIVKQRLERINPE--IEVKTVVEF---------------------------LENERIHELVSAG----------------FDYVVDAID---SVSPKVFLIKNVMEA-------------------------------KIPLVSSMGAGGRFDPTKIQIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DISLSHKD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLTRLVRYRLHKHGIRS--------------------------------------------------------------------------GFNCVFSSEE-------PDRAALMFHQ-----ERFKKSSFGT/
FINAL HHHHHHH-EEE----HHHHHHHH---EEEEEE----HHHHHHHHHH--------------EEEE----EEE-----HHHHHHH--------HHH-HHHHHHHHH------EEEEEE-------------------------------HHHHHHHHHH--------------------EEEE------HHHHHHHHHHHHHH-----------------------------------EEEE--EE---EEEEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH---------HHHHHHHHHHHHHHHHH----------------------------------------------------------------------HHHHHHHHHHHHH-------H------------------------\FeeI
15609475 Mycobacterium_tuberculosis_H37Rv DEAFCRNLGLI---SPTEQQRLRNSRVAIAGMGGVGGIDMVALARMGI----------GKFTIAD-PDVFEIRNSNRQYGAMRST---NGQAKA-EVMRNIVHDINPE--AEIRAFCEP---------------------------IGKENAATFLEG-----------------ADVLVDGIDAF-EIDLRRLLYREAQQR-------------------------------GIYALGAGPLGFSTAWVVFDPKGMTFDRYFDLSDAMN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVDKFVAFIAGIAPS-------------------------------------------------------------ATHRRSI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLSYVDIENRTGPSVGLACHLASGVVAAEVLKILLGHGR-----------------------------------------------------------------VYAAPYFHQFDAYR-------SIYVRKRLR-----CGNRHPLQRVK|
78223253 Geobacter_metallireducens_GS_15 RNEFARNIGLL---TVEEQKRLLASRVAVAGAGGVGGIHVLTLARLGV----------GCFTIAD-HDSFDVVNISRQFGAFHST---LNRNKA-QVLAEMVKDINPN--AEVRVMEEG---------------------------VTEDNINAFLDG-----------------VDVYVDSIDFF-EIDMRRLIFNSCRAK-------------------------------GIYALTAAPLGFGATLQVFDPEGMSFDDYFGIDDQTP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLEKIAAFAAGLTPN-------------------------------------------------------------PYHLSYM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DASRVSFKRRTGPAVSPACTLAASLVATEIVKILTGKGE-----------------------------------------------------------------LRPIPCYLQFDMLL-------NKVKMGKIA-----LGAKSPSQKKK|
78355869 Desulfovibrio_desulfuricans_G20 DTAFCRNLGLL---TYDEQRKLLDSRVAVAGLGGVGGEHLVTLARTGF----------GKFTIAE-FDEFSPVNVNRQYGATVSA---FGRAKL-DVMLEYAMGVNPF--LDIRKFPSG---------------------------ISEENLDDFLDG-----------------VDVVVDGIDFF-AFDIRCALFMRAYKK-------------------------------GIPVITAGPMGYSCALLVFMPGGMDFIKYFDIRDDMD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQEKLLRFALGLAPR-------------------------------------------------------------ALHVRYL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRRFVDMRERRGPSLDIACRVCAGMATTEAVRLVLGKKG-----------------------------------------------------------------VRAVPEYTQFDPFT-------GKYHRGKLK-----KGLASFPQKLK|
88812577 Nitrococcus_mobilis_Nb_231 QLAFSRTVGWV---TREEQAILRSKRVAIAGLGGVGGSHLLTLTRLGI----------GAFTLAE-MDHFELENFNRQAGAFLST---VGRPKL-DVLSGMAQGINPE--LNIRTFPEG---------------------------ISGENLDDFLAN-----------------VDLYVDSLDFF-ELDIRRKVFAACAEH-------------------------------GIPAITTAPLGMGTAVLAFLPGGMTFEQYFRL-EGHP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEEQYLRFLLGLSPA-------------------------------------------------------------RLQMGYLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPSAVDLAAHRGPSTPMACALCAGIAGTEALKILLRRGR-----------------------------------------------------------------VIMAPHGYHFDAYR-------QRLARTWRP-----LGNRNPIQQTA|
56479527 Azoarcus_sp_EbN1 DAAFVRNLGWV---TALEQAQLRRKRIAIAGMGGVGGVHLTTLARLGI----------GAFNIAD-FDSFDLANFNRQAGATMSS---LGRPKV-DVLAELALDINPE--LDIRRFPKG---------------------------VSDANLDKFLDG-----------------VDLYVDGLDFF-SFAARRATFAACHRL-------------------------------GIPAVTAAPLGMGTAVLTFIPDGMSFEEYFCL-EGCD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEMAIRFLLGLSPG-------------------------------------------------------------MLQRGYLA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPSRVDLSEQRGPSTIAACQLCAGVTATEALKLLLGRGK-----------------------------------------------------------------VLAAPRGYQFDAYR-------NSFIKTWRP-----GGNRNPLQRLG|
111022716 Rhodococcus_sp_RHA1 LLRLDRNRNKI---TAQEQERLRDVTVGIVGLS-VGHAVALALTLEGAC---------GGLRLAD-FDTLELSNLNR-VPGTVLD---LGVNKS-VVAARRIAEIDPY--VTVTLWEDG---------------------------LDVGSVAEFLDG-----------------TDVVIDECD---SLDVKVSLRREARRR-------------------------------GLPVLMATSDRGLLDVERYDLE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDRPVFHGVIGDVDV-------------------------------------------------------------ESLAGLG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRDKIPLVLRILDAGQLSATMAASLVEVDETIST-WPQL-----------------------------------------------------------------GGEVLLGGAQVAAA-------VRRIGLGQP-----LASGRCRMDLD|
15840810 Mycobacterium_tuberculosis_CDC1551 AVRLDRNRHLI---TAEEQRALHALRVGVVGLS-AGHAIAYTLAAEGAC---------GTLRLAD-FDKIELSNLNR-VPVGVFD---IGLNKA-MIAARRIAELDPY--LAVDLVTSG---------------------------LSPESVDEFLDG-----------------LDVVIEECD---SLDIKVILRQAACAR-------------------------------GVPVLMATSDRGLVDVERYDVE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGRPIFHGLLGDIDA-------------------------------------------------------------DKLCGLT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKDKVPHVLNILDCQELSARCAASMIEVDQTLWG-WPQL-----------------------------------------------------------------AGDIWVGAATVAEA-------VRRIGLGEP-----LESGRVRVDVS|
110639176 Cytophaga_hutchinsonii_ATCC_33406 EVRTNRNQYKI---TPEERDKLSKQKIGVIGLS-VGQSISLTLALERSF---------GELRIAD-FDVLELSNLNR-IRSGLSN---LNLKKT-VCVAREILEIDPF--LNVTLFSDG---------------------------ITEDNIDDFFLKNGK--------------LDLVIDECD---GLDIKILCRYKAKEL-------------------------------KIPVFMESSDRGTIDIERFDLE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDRTILHGLIDHLDH-------------------------------------------------------------KKLKYLKT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEEKIPYILPMLGTDTISKRMKASMVEIEQTITT-WPQL-----------------------------------------------------------------ASSVVFGGGIGADI-------CRRIILDQF-----HDSGRYIVDME/
FINAL HHHHHHHHH------HHHHHHHH---EEEEEE---HHHHHHHHHHH-------------EEEEEE---EEE-----EEEEE-----------HH-HHHHHHHHH------EEEEEE---------------------------------HHHHHHHH--------------------EEEEE------HHHHHHHHHHHHH----------------------------------EEEEEEEEE--EEEEEEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E--HHHHHHHHHHHHHHHHHH---------------------------------------------------------------------HHHH--EEEEEHHH-------HHEEEEE-------------E----\MccB
67551179 Escherichia_coli SRNFLHYQSYGAN-PVLVQDKLKDAKVVILGCGGIGNHVSVILATSGI----------GEIILID-NDQIENTNLTRQVLFSEND---VGKNKT-EVIKRELLKRNSE--ISVSEIALN---------------------------INDYTDLHKVPE-----------------ADIWVVSADH--PFNLINWVNKYCVRA------------------------------NQPYINAGYVNDIAVFGPLYVPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTGCYECQKVVADLYGSEKENI------------------------------------------------------DHKIKLINSRFKP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATFAPVNNVAAALCAADVIKFIGKYSE-----------------------------------------------------------------PLSLNKRIGIWSDE-------IKIHSQNMG-----RSPVCSVCGNR|
116073134 Synechococcus_sp_RS9916 DRHELYYDIFGKS-KEDYSG-LKNKKVGLIGAGGIGSSVSMLLAAAGV----------GTIKLMD-DDLLEETNLPRVVLLEEAD---VGLPKV-QQIQKRLMDRNSS--CKIAFQESKI--------------------------KSHEEIAEFLGD-----------------CDAWVLSADSP-PKTICSWTNQAALKC------------------------------NVPFITAGYAEINGLIGPFIIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTACHFCRLEEDK---------------------------------------------------------------TTDRIQLNSRLQA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSYGPLNTIVASMAVNEVIRFLLGLE------------------------------------------------------------------VATAGKQFILDSSS-------YKMIEKSIA-----IHPECE-CQQQ|
115521890 Helicobacter_pylori FKNHLFIDLMSNK-PELTINNFKRTIFIIIGCGGIGNFVSYALASFYP----------KKLILLD-KDTVDPSNLNRQFLFDKNY---ISQYKT-SAIKQALSSRFG---INIETVDDFASE------------------------DNLEEIFSKHKKE----------------NLFGIVSGD---NPNTVQLATRFFCKC------------------------------RIPFLNIGYLNDISLIGPFYIPS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSCCPFCHNSFALDDKKDGDK-------------------------------------------------------NLDICLINDRMQA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSSFLNNSIASSLAISDIIQFMSDDFNS----------------------------------------------------------------IKSLNCRFGVDNKI-------FKTYTLPSS-----IDHKCVFCSNH|
55823830 Streptococcus_thermophilus_CNRZ106 FKNGLYLDLIINN-VQDVLTKFKETTFVVIGCGGIGNFMSYALSVYSP----------KKLVLID-GDKIERSNLNRQFLFTIND---IGKYKS-EVIADALKLRNPN--LDIEVYTEFIST------------------------NNINNILEGKDTN----------------SMFGILSGD---DDTAVSISSKYFLTN------------------------------NVPFVNIGYLNDIAVISPFVIPH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSCPFCYGTFSINGEINSN--------------------------------------------------------DETMAQLHKQYAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSSIINNSLACDLALSDIIQYFAGNNDS----------------------------------------------------------------IKSLNARVGINSNS-------FEKYVLPNT-----KDPNCSICGGT|
113460167 Haemophilus_somnus_129PT SRNHLYYNALGYK-IYDIQNKISKSHILIVGAGGIGNICSYLLGTIGI----------KKLSIID-DDIVEESNLNRQFLFREKD---INKNKV-ETIKRELLSIRKD--IIIDIFPEK---------------------------LN-KSILDKISQ-----------------IDLVICSAD---DEYCIDMINEFCCFN------------------------------KIPLINVGYLNDISVIGPFYIPKLE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSCCLCCDKSIYLENDVI----------------------------------------------------------DEKVKKIKSVTKA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSTIINNFFAGAMLGSELIKFFACDYKS----------------------------------------------------------------MQSINSVIGIHNKN-------FKYEEIKLA-----RNYNCKYCGVN|
49475959 Bartonella_henselae_str_Houston_1 SRSHLHYQSYGMH-PASVQHTLSQKVVVILGCGGIGNHVSAILASSGV----------GKLILVD-NDVIEMTNLTRQILFTEED---IGLPKT-TVLQRELIRRNSQ--SEVHELQMF---------------------------ITEKEDINKLPK-----------------ADLWIISADS--PDMLRPWINEWCVKN------------------------------KQAYINSGYVNDIAIFGPFYIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTGCYACSTSIENLPEKGDSLI------------------------------------------------------HEACTAINNNFKV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATFPPVNALSAAMCANDALKFLGGYGN-----------------------------------------------------------------LLSIDRRVGIWSSQ-------LFTEERSLK-----KNPHCKVCGTP|
37525466 Photorhabdus_luminescens_subsp_lau SRNYLFYRYAGAI-PSLVQDRIKKSTVTIIGCGGIGNHISYLLSTSGV----------GKITLID-DDTIELSNLTRQVLFSQND---IGRKKT-EVLERELNKRNSE--TNIETINMF---------------------------ISSINDLYKIPR-----------------SDLFIVSADH--PFELINWINEFCVKE------------------------------RQAYINIGYINDISVIGPFYIPN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSCIKCQNIMPEYHPKDDI--------------------------------------------------------LEHIENVNKDFKA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATFPSVNGVAASYAFGDIMKYLGSFGN-----------------------------------------------------------------ILSTNKRIGIHSLS-------IKIEEQSIH-----KNDKCDVCSQK/
FINAL ---HHHHHH-----HHHHHHHHH---EEEEEE----HHHHH-HHHH-------------EEEEEE---EEEE-----EEEEEE--------HHH-HHHHHHHHH------EEEEEEEEE-----------------------------HHHHHHHHH--------------------EEEE------HHHHHHHHHHHHHH-----------------------------------EEEEEEEEE--EEEEEE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE-HHHHHHHHHHHHHHHHHHH----------------------------------------------------------------------HHHHHHHEEEHHHH------HEEEEEE------------------\PaaA
47568948 Bacillus_cereus_G9241 LTFYTNFTSLEKN-KFEFQKKIKDSTVAILGLGGASLGVAC-LTGLGV----------ENIIGVD-YDLVETSNLNRQFLYSEKN---IGELKT-EATLNRLKELNSD--VNFKFINKKI--------------------------KSSDDLNSIIKE-----------------ADIVINAID-SPAILCNRWVNAACVKQ-------------------------------NIPFIQGGVSNTQIIWERIVPN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSGCYDCYLIHALRLDPFFEYQLKAI--------------------------------------------------YNNHFPGRN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTTGPHVALLNGFMTSEVAKLLSGYTE-----------------------------------------------------------------AMPASTTMIYDKINI------EIKKNFKWD-----KLPDCPTCGKE|
106894495 Clostridium_sp_OhILAs INFIEDFSSNKED-VLEMWNNIRDSKVVVIGLGAVGTWVSALLVQNGV----------GNITLID-NDLVEISNLHRQFGYGEDD---VGLLKT-DALEKRLREFSSD--VRINTVNEFL---------------------------EEDNLEKILDYK----------------VDLIINCADKPSVDVTSTWVGEYCMKY-------------------------------NIPHIIGGGYNLHISLMGQTIIPF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESACVKCFEKELSRLNNIDESNIKKL--------------------------------------------------TVKN--RKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSFGPMCSIIASMTAMEGIKLLTKKIT-----------------------------------------------------------------PANLNRRGEFSIYNM------DINYHYVS------KDEECSWCGKE|
75759314 Bacillus_thuringiensis_serovar_isra INYFSLFTKFGED-KYKIQEKILETPIALLGVGGLGTQVLYHLAALGF----------HNIKALD-FDNIELSNFNRQLLYSESD---IGNSKV-EMAKKRISQFNPN--VDLQIINKKI--------------------------ESPQDVIEHIEG-----------------TELVICVAD-KPTLHIANWVNEGVVKC-------------------------------NLPMVYGGVLNTRGRFFSMIPS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTGCVQCHINYARQLNDKQDEQLEAM--------------------------------------------------NNMEFTRNN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAISPNVAIVAGTIVNEALKILTQIAQ-----------------------------------------------------------------PISLGKVMEVDFLTL------ETNTVSSWE-----KMLDCPLCGQV|
29375896 Enterococcus_faecalis_V583 VNYFSRYCKADDD-RFEIQEKINNLKILLLGLGGGGSNILTLLAGLGP----------KMIRMVD-YDRVEASNLGRQLLYREAD---IGEKKT-VVAKRAINEMNSN--INVETVDKKI--------------------------IDVNDVVELTEG-----------------IDIIVCAID-EPPFLIHRIVNEAIVKV-------------------------------GLPCVFGASQVSRGRVYTVIPQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTGCFDCMNLNFSKNDPKFVEQFVGF--------------------------------------------------RNIQFAPPS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAYGPGIFQLTASIVDELIRVVTRYAE-----------------------------------------------------------------PKSLGTQYEINYEDG------NSFTHKTWPR----FESECPTCGKG|
116627432 Streptococcus_thermophilus_LMD_9 IYYFSRYLNSFKD-SIDIQKRLNETTVLLLGLGGGGSNILTLLSGLGP----------KKIKIVD-FDIIEKSNLGRQFLYKEED---VGALKT-QIAHQEVSKMNSD--IEVETHNLRI--------------------------TCVNDLLPLLDN-----------------VDIVICVID-EPQYDIQRIVNKAVVTK-------------------------------NIPCVFGASQVSRGRVYSVVPH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTGCFDCLNIHYTKIDSLFLEQFRGI--------------------------------------------------RTVTKKIPT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IAYGPAMFQLTSAIVDEAVRLITKYAE-----------------------------------------------------------------PMSLNRQYEINYENG------ASFTHKPWDI----ILMSVLHVVTV|
7934570 Pantoea_agglomerans ILQFSLIDADNQH-PFVYQERLKQSKVAIFGMGGWGTWCALQLAMSGI----------GTLRLID-GDDVELSNINRQVLYRTDD---VGKNKV-DAAKDTILAYNEN--VHVETFFEFAS-------------------------PDRARLEELVGDSTF--------------IILAWAALGYYRKDTAEEIIHSIAKDK-------------------------------AIPVIELGGDPLEISVGPIYLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-GVHSGFDEVKNSVKDKYYDSNSDIRKFQEARLKHSF--------------------------------------IDGDRKVNA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WQSAPSLSIMAGIVTDQVVKTITGYDK-----------------------------------------------------------------PHLVGKKFILSLQDF------RSREEEIFK----------------|
84495334 Janibacter_sp_HTCC2649 LAFFETFASLAAS-QEDLVDRVRSSHVLVLGTGGLNSTTIPHLAGAGV----------GRLTVAD-RDVVEAKNFARQYLYAWEQ---IGRPKV-EEAARWIRRFDPT--IEVEARHLDV--------------------------TGTASVAALLDELS---------------PDLVMSGID-TPREV-DLWVNDACMAR-------------------------------GVPLVRGGMGISTAGVWSVWPD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSPCRRCLAMQADAVNASAAEGAAEVTTRDDVHALAAQ--------------------------------------RISEGRTRVN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGIGPIAGLIGSFAAFEVLRYLTGYEE-----------------------------------------------------------------PQYAGRLLNIDLKNG------CATTVRPWE-----KVPTCAACLGR|
37526106 Photorhabdus_luminescens_subsp_laum LNGFAALSDNGIS-PAEYQQKLFKGHVLLLGCGGLGSCTATALAMTGC----------GTITVVD-FDDIELSNLNRQ-LYIVDD---IGMRKV-EGLKSRLNKINPD--VTVNTVFKRI--------------------------TGSDVVKELISQFK---------------PDIVVAAID-RPVIAADRWISDACFDM-------------------------------GIPGVFNSVSAGMGMFWTKFPD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSGCFRC-DEKWSRTQDPDHYSMRAW--------------------------------------------------REEHDLIPAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAFSYSAMIVGGMMSADIIRKLVGWPM------------------------------------------------------------------ISAGKLVTISFTTL------QTNVEDKP------QHPDCELCAY-/
FINAL -------------------HHHH--EEEEEE----HHHHHHHHHH-------------H-------------------------------------------------------------------------------------------E-E------------------------EEEEE-------HHHHHHHHHHH-----------------------------------EEEEEEEE---EEEEEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------EEEEEE--H-------HHEEEEE------------------\Rv3196-like
54026503 Nocardia_farcinica_IFM_10152 ------------------ERPRDVRVVRVHGLGPLSDAVTAGLRG-------------LGVRAARS--------------------------------------------------------------------------------RGYRPEKPARGT-----------------HADLVVLTDT--VVVDPRLVADLVIHR-------------------------------VPHIHVRVRDGKGIVGPLVLPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATSCLRCADLTKADYDPDWPHLAA----------------------------------------------------QLLDRVGHA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPAAVAATAALALGELEAIVEGSARRA-----------------------------------------------------------------PATLDATLELDLDT-------YQLHHRPWN-----PHPRCG-CRRL|
108798383 Mycobacterium_sp_MCS ------------------PRHGRTPSVRIHGRGPLSDLLVAGLRC-------------SGARVG----------------------------------------------------------------------------------HTRSPKPPAPPE-----------------ATDLVVLADY--LVAEPRVVRDLHDAH-------------------------------VAHLPVRVRDGCGLIGPLVFPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSCLSCADLHRSDRDAAWPTLAA----------------------------------------------------QLRGTVGSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRPTVLATAAVALDRIHRVLRAIRDTGDPAAAAD----------------------------------------------------------PAATDTTWEFDVGT-------RTTVVRRWS-----RHPRCT-C---|
41409392 Mycobacterium_avium_subsp ------------------RSGGRAPSVRIHGRGPLSELLVESLRC-------------SGARIA----------------------------------------------------------------------------------HSSQPHAAVSGD-----------------DVDLVVLSDY--LVADPRLVRDLHEQG-------------------------------VAHLPVRVRDGVGLVGPLVIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTSCLSCADLHRRDRDAAWPVICA----------------------------------------------------QLRDTVGVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRATVLATAALALSQVNRVIAAVRGQPAASDPAP----------------------------------------------------------PQTLNATLEFDLHA-------GAIVARRWD-----RHPLCS-C---|
118617990 Mycobacterium_ulcerans_Agy99 ------------------HRTGRTASIRIHGRGPLSDLLVQALRC-------------SGARIG----------------------------------------------------------------------------------QSSQPHAAVTRS-----------------AVDLVVLSDN--LVAEPRLVRDLRREG-------------------------------IAHLPVRVRDGTGLVGPLVIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTSCLRCADLHRSDRDPAWPAIAA----------------------------------------------------QLRDTVGVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRATVLATAALALRQINGVIAAVRDQENPSDP------------------------------------------------------------PSALNATLEFDLQA-------GSVVARYWA-----RHPLCS-C---|
120402810 Mycobacterium_vanbaalenii_PYR_1 ------------------PGVDRSPAVRVHGSGPLTDLLTASLRC-------------SNVRIS----------------------------------------------------------------------------------QSTRTHA-STA------------------GADLVVLTDY--LVADPRVVRELHDAG-------------------------------VAHLPVRVRDGTGLIGPLVIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTSCLRCGDLHRSDRDPAWPAVAA----------------------------------------------------QLCRTVGSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRPTILATAALALREIEHVLRAVRGAGTDS--------------------------------------------------------------PSTLDTTLEFEVAT-------GTSTARRWS-----RHPSCG-C---|
119882897 Salinispora_arenicola_CNS205 ------------------LRRRRTARVLVTGAGRLGAPVAVALAQ-------------AGVGHVQ-PRLAGPVTPADLVGTGIPA---AELGQP-LADAVRETLGRTA--PGTAI----------------------------------GPLR-PG-------------------RTDLVIQCGT--DRPAAVLAAAHGQRR-------------------------------QAHLLLDLREGVPVVGPLVRPP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGPCLNCLDQHRRDRDPSWPALAA----------------------------------------------------QLSGGTPER---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ICATTAMLAAVAYAAGEALGHLDSGT------------------------------------------------------------------PTTVGCSVEVT-AT-------GRLRRRHWA-----PHPSCA-CSGR|
117928975 Acidothermus_cellulolyticus_11B ------------------LERRRAARISVVGAGRVGATVATLLAA-------------AGIGRVV-PDDPEPATAADCAPGGLAP---ADAGTP-RGDALRRRLLAVN--PAVQT----------------------------------APPT----------------------DGDYTLQVLAPPGPFDATVGDAALRGH-------------------------------TPHLLAFVRDLTGVIGPLVSPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSPCLRCLEAARAARDPRWPLIAA----------------------------------------------------QLASDPPRKRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACDVVLATLVAAIAALQVLAFVDGRR------------------------------------------------------------------PATVGATVEMTLPD-------WRFRRRRWS-----MHPDCG-CGWP|
86742467 Frankia_sp_CcI3 ------------------LATRRAMRVLVRGAGRVGAQVAALLAA-------------AGIGRVV-IDDPEVTTAADVSPGGLRL---DDVGRP-RSLATGAAVTRAS--RQGAG--------------------------------HRRPDE-DRF------------------AADLIVLAPVGLPMIHPGECLDLEGRG-------------------------------TAHLVAGVRETTGIVGPLVVPT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTACLHCQHLHRYSRNPVWPVLAM----------------------------------------------------QMVHRPATGPD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACEITLAGLVAALTAMQALAFLDLAASPPPDLSALSALSALSAPPDLSGVTGPAPGQHPDNSDHLPPTASSHNETFITLTSPRTVLPVTAVLPVTADGTLEFTVPG-------WRIRRRTWP-----VHPNCP-CRTA|
111225377 Frankia_alni_ACN14a ------------------LAARRAARVLVRGAGRVGAQISTLLAA-------------AGIGRVV-VDDAAVTTAADVSPGGLRL---EDIGRP-RALAAGTAMTRVR--RQADRRPGLGPAGSTPLPPSG---------------HAEGPGV-DGF------------------EADLIVLAPVGPPTVAPGACLDLERRG-------------------------------TAHLLAGVRETTGIVGPLVVPA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATACLHCQHLHRHARDPVWPMLAM----------------------------------------------------QLVRPRTAGHD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PCEITLASLVAAIAAMQALAFLDLAVPPSPDPGPRVHQSDNPDLLHAIASTKDEMFDTPDSSLKIF--------------------------PVTADGALELALPD-------WRIRRRSWP-----VHPNCP-CRTA/
FINAL ---------------------HHHHHHHHH---HHHHHHHHH----------------EEEEEE-----HH-------------------------------------------------------------------------H-HHHHHHHHHHHH------------------EEEEEE-----HHHHHHHHHHHHHHH----------------------------------EEEEE----EEEEEEEEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHH------HHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHH-----H--------------------------------------------------------------------EEEEEEEE--------HHHHHHH------------------\GodD
115375227 Stigmatella_aurantiaca_DW4/3_1 ----------------PGIPPETAAFWQALGVTPSEAAARIAASP-------------VAVRALD--GLDA-------------------------------------------------------------------------APLIDALKGAGLTVQDTA-------------ALQAVLVRDY--LSPELEAFNQQALKQ-------------------------------QTPWFLVKPTGATPWAGPVLRPG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGPCWACLAHRLRWNRPVEAYLNGR---------------------------------------------------KGSTGPRLPPR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AELPASLQAGLQLAATALARWIVTGGK-----------------------------------------------------------------GALGQTLLALEFAQ-------FQLTEHTVV-----RRPQCPACGDP|
113475987 Trichodesmium_erythraeum_IMS101 ----------------PELPPPAAAFWSLLNVEPQFASDCLQKNT-------------VYIASVG--ETTT-------------------------------------------------------------------------DLLIESLTAVGIKTKPWENYPLTSDRK----ALLVVLTDDY--LQPQLKEINKTALSA-------------------------------SQPWLLAKPVGGVLWLGPIFEPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTGCWECLSQRLRGHREVEATVLRQKEKSVVSSAS-----------------------------------------KRDVTGCLPPPP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFLPSTLATGINLITTEVAKWIVKESGVEMPKF-----------------------------------------------------------TTLAGKVVTFNQTD-------FSTTTHILS-----KRPQCEACGDS|
114567303 Syntrophomonas_wolfei_subsp_wolfe ----------------GDFPREQLAFWSALGVETPALLEKVKSNP-------------VSVISLG--NDST-------------------------------------------------------------------------GTLLSILREMQLEIAEKA-------------ELLIVLVDDY--LQPELEELNQKFYRE-------------------------------KQSWILVKARGSIPWLGPLFIPR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTACWQCLAQRLQNNRDVEEYIRRQ---------------------------------------------------QELQSPVNIPQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLPATRALVWNLLAVEVAKQLLSGQS-----------------------------------------------------------------LFSENKMISLDIYN-------MSIESHTLV-----KRPQCPICGQA|
4218544 Streptomyces_violaceoruber ----------------GAGPPAAHDRSAEAFWDLAGTTPPARTAV-------------RLLVLDG--PVSE-------------------------------------------------------------------------EEARAACAASGLDVGRPGAQASDA-------EVTLVLCTDY--LDPRLADVDALQRAA-------------------------------GRPWILARPGGPEAWTGPVLRPD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGPCWHCLAERLRLQRGSEAPLHRA---------------------------------------------------LGCTSPVARPD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASLAASRAAGLHTAVLETAKWLAGVP------------------------------------------------------------------GPTRDAVHTVDALT-------LDSARHPVA-----RRPQCPSCGDA|
124003741 Microscilla_marina_ATCC_23134 ----------------DFFTPEQAAYWESAGFNTTHLAQVLQQKT-------------IGLISVG--VAQE-------------------------------------------------------------------------VFE-DACCQAQLQLSATP-------------DVYLVITKDY--NHPELSQLNQQFEQS-------------------------------KTPWLLVKPTGQTLWWGPVFVPG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTACWQCLHHRLELHNPINKFYKNI---------------------------------------------------KNTAQAPSKPL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSHPATFQMAASFAVLALVKWLYHQPT-----------------------------------------------------------------DASETQITSFNTQT-------LEKQHHAVV-----KRPQCNACGDV|
27379649 Bradyrhizobium_japonicum_USDA_110 ----------------PAFDEAVGGFWASLGLSPEVAEQNLRSCS-------------VQIESID--VKGA-------------------------------------------------------------------------KELTAALSRLGVQIAKRSP------------KLTITLVNDY--LDRRLAELNQERVAG-------------------------------KTHWLLVQPSGAFPLVGPMFKPG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESSCWTCLFDRMIRNREIKGFLD-----------------------------------------------------RGPARAVAISPL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNHPVGRTAIHFAAVEIAKAIASGFR------------------------------------------------------------------TDLRDHIASFDLAG-------AVIAKHYVA-----RRPQCPTCGSK|
120611723 Acidovorax_avenae_subsp_citrulli_ -------------------RGAVPGGWAVPHVDAAPVREEGDAGS-------------VTWLVEP--GGLP-------------------------------------------------------------------------AWR-ATVDAAGGGAVA---------------GVDLVLCEDH--FDPRLAGEWERALRAGR-----------------------------SRWWMPVRLGGTRSIAGPLLRPGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGPCWHCFLHRLRRNSPERGWLERE---------------------------------------------------VPGSHGLVPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FSDPAGRAPRWRQVQEAVRRLLADAVPGRF--------------------------------------------------------------AVFGSPRGPGGGED-------DTGPWQSVP-----RRPQCPRCGDA|
78186744 Pelodictyon_luteolum_DSM_273 ----------------PGINPHVAGFWQGLDLEPQSAIESIRNHG-------------VRILGIG--EVET-------------------------------------------------------------------------EPLANGLLSLGVKIVDKANES----------TLDVVVVDDY--LNEELAAISKIARIE-------------------------------GRSILPLRPSGFECWIGPLFKPD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQGCFLCLRHKLERHRLVHRFAVA----------------------------------------------------HGKRPGSNLP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSDITRNAAYALGSAAIVKVLAGSD------------------------------------------------------------------SGLEGRIFSLDIRT-------WASRTHTLS-----ENPYCPVCGVA|
168143101 Bacillus_cereus_G9842 ----------------------MTQNILLIGDGL--------------------------------------------------------------------------------------------------------------LADYVHDQLCKQYSIIRQHTLTEELPEN---IYLALVLHDGS-PSPIHHDAELIFRSN-------------------------------HIPWLRGFTSFGEGIIGPYIHPL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPGCSHCSDGRRFIAGFDQKEMWELQRKYAF---------------------------------------------KAENGTRRDV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RATQNGMLQMCHLICAETEKILTHNH------------------------------------------------------------------SSLENELILLNLQT-------LQCTRHSFL-----PDPLCPVCSSL|
30261362 Bacillus_anthracis_str_Ames ----------------------MTQNILLIGDGI--------------------------------------------------------------------------------------------------------------LADYVHDQLYKQYSIIRQHTIADELPEN---IDLALVLHDGS-PSTIHHDAELTFRSN-------------------------------HIPWLRGFTSFGEGIIGPYIHPP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAGCTHCADGRRFIAGFDQKEMWELQRKYAV---------------------------------------------KEENVTRRDV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RATQNGILQMCHLICAETEKILTHNH------------------------------------------------------------------PSLENELILLNLQT-------LQCTRHSFL-----PDPICPVCSNL|
159038169 Salinispora_arenicola_CNS_205 ---------------------------MNDGTTA--------------------------------------------------------------------------------------------------------------ADDLVRAGLARLLAERGCDADV---------VAVGVRDELSATPRPER-GPRVLLYGQ-------------------------------LA------------LIGPVPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAACSICLARRWQAVRHRDLRDALEL--------------------------------------------------GGDTVAAGPW--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYATPLVADFLHALIAARRTAATGPAGTG---------------------------------------------------------------TVTPSTVFQVDLST-------LRVHQVPLL-----PDPECPACGDM|
86742875 Frankia_sp_CcI3 -------------------------LPIPALVRV--------------------------------------------------------------------------------------------------------------RGAIDEAWHEALADLPDA-------------VGSTVSLGIGW-DLAWEREQWRSAVED-------------------------------RRSHLSVRLYADETLIGPLWAPAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAGCSGCAEVRSRVVRAHPM--------------------------------------------------------VEALQVPTEV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPRSPL--LPELLAAAVQHLTAQ--------------------------------------------------------------------PLGPGELYAVGTGS-------TR--RHRVP-----RSSGCPLCGAR/
consensus/100% ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
consensus/95% ..........................h.h.s....s......h.................h.....................................................................................................................h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
consensus/90% ..........................h.lhGhss.Gs.....h.................h.h.c....h...s..................+s....................................................................................hh..............h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..........................................................................................h....................................
consensus/85% .........................ph.lhGhushGs.hh..l...s.............l.lhD..p.hp..sh.p...............+s.......h..........................................................................phhh.s.s...s......h...h.....................................h......s..s...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hs.......h..h...............................................................................h....................................
consensus/80% .....................h...plhlhGhGulGs.hh..lh..uh...........pl.lhD..s.hp.psh.cp...........s..+s...h...h..........................................................................shlh.s.s...s...b..l...h.....................................hh.s...s..s.............................................................................................................................................................................................................................................p...........................................................................................................................................................................................................................................................................................................................................................................................s.hss..s.phh..h.............................................................................h.hs...................................
consensus/75% ..................b..hpp.plhlhGhGulGs.hh..Lh..Gh...........pl.lhD..c.lp.psh.Rp.h.........sb.Ks...h.p.h..b.s..............................................p.h...................hshlh.s.D...s...b..ls..h.....................................hh.ss..u..s.............................................................................................................................................................................................................................................p..p..........................................................................p.............................................................................................................................................................................................................................................................................................................shhush.s.phhb.h.............................................................................h.hs............................p..p...
consensus/70% ..................bp.lpp.plhllGhGulGs.hhb.Lhb.Gh...........pl.lhD..-.lp.sNlsRp.hh.......hGb.Ks..hh.p.l.ph.s..............................................phh...................hshllss.D...s..sc..lsphh.....................................hl.ss..u..u.............................................................................................................................................................................................................................................sb.p..........................................................................s......................................................................................................................................................................................................................................................................................................s..ss.sshhush.s.chhbhl.............................................................................h.hs.................h..........p..p...
II. Alignments of domains fused to E1-like domains
A. U5C--UBA5 C-terminal domain
FINAL -HHHHH-HH-----HHHH-------------EEEEE-------------------------------------------EEEEEEE-----------EEEEE-----HHHHHHHHHHH--
ALIGN --HHHH-HHH---HHHHHH------------EEEEE---------------------------------------------EEEEE------------EEE------HHHHHHHHHH---
HMM --HHHH-H-------HHHH-------HH---EEEEE---------------------------------------E---EEEEEE-------------EEEE--E--HHHHHHHHHHH--
FREQ -HHHHH-HHH---HHHH--------------EEEEE--------------------------------------------EEEEE----------E-EEEEE-----HHHHHHHHHHH--
PSSM HHHHHH-H------------------------EEEE-------------------------------------------EEEEE--------------EEEE-----HHHHHHHHH----
68403668 Danio_rerio PKQEVV-QEE---EEVVHE-------DNEWGIELVSEVTE-----AELQDAS-------------------GPIPDLPEGITVAYTIP--EKDGGS-GETVE--ETEQSLEELMAQMKKM
48976121 Gallus_gallus PKQEEI-HQE---EEIVHE-------DNDWGIELVSETTE-----DELKAAS-------------------GPVPDLPVGITVAYTIPNKEENLTA-EETVA--ESEESLEDLMAKMRNL
52345484 Xenopus_tropicalis PKQEPIVVKE---EEIVHE-------DNDWGIELVSEVSE-----EELKAAS-------------------GPVPELPEGIKVAYTVP--ITEPTS-GFIVE--DSEQSLDELMAQMKNL
76779963 Xenopus_laevis PKQETVVVEE---EEVVHE-------DNDWGIELVSEVSE-----EELKAAS-------------------GPVPDLPEGIKVAYTIP--ITKPTS-GFTVE--DSEQSLDELMAQMKNL
57527209 Rattus_norvegicus PTQETAPQEE---EEVVHE-------DNEWGIELVSEVSE-----EELKNSS-------------------GPVPTLPEGITVAYTVPKKREDSVS-EVTVE--DSGESLEDLMARMKKM
74223168 Mus_musculus PTQEAEPQEE---AEVVHE-------DNEWGIELVSEVSE-----EELKNSS-------------------GPVPTLPEGITVAYTVPKKTEDSAS-EVTVE--DSGESLEDLMARMKNM
76363459 Mus_musculus PTQEAEPQEE---AEVVHE-------DNEWGIELVSEVSE-----EELKNSS-------------------GPVPTLPEGITVAYTVPKKTEDSAS-EVTVE--DSGESLEDLMARMKTM
76626332 Bos_taurus PKQEVI-QEE---GEIIHE-------DNEWGIELVSEISE-----EELKKSS-------------------GPIPDLPEGIIVAYTVPQKQEDSVP-EVTVE--DSGESLEDLMAKMKNI
73990092 Canis_familiaris PKQEAI-QEE---EEIIHE-------DNEWGIELVSEVSE-----EELKNSS-------------------GPVPDLPEGITVAYTIPKKQEDSVA-EVTVE--DSGESLEDLMAKMKNM
75041643 Pongo_pygmaeus PKQEVI-QEK---EEIIHE-------DNEWGIELVSEVSE-----EELKNSS-------------------GPVPDLPEGITVAYTIPKKQEDSVT-EVTVE--DSGESLEDLMAKMKNM
67967838 Macaca_fascicularis PKQEVM-QEE---EEIIHE-------DNEWGIELVSEVSE-----EELKNSS-------------------GPVPDLPEGITVAYTIPKK------------------------------
114589264 Pan_troglodytes PKQEVI-QEE---EEIIHE-------DNEWGIELVSEVSE-----EELKNSS-------------------GPVPDLPEGITVAYTIPKKQEDSVT-ELTVE--DSGESLEDLMAKMKNM
38327032 Homo_sapiens PKQEVI-QEE---EEIIHE-------DNEWGIELVSEVSE-----EELKNFS-------------------GPVPDLPEGITVAYTIPKKQEDSVT-ELTVE--DSGESLEDLMAKMKNM
14042326 Homo_sapiens PKQEVI-QEE---EEIIHE-------DNEWGIELVSEVSE-----EELKNFS-------------------GPVPDLPEGITVAYTIPKKQEDSVT-ELTVE--DSGESLEDLMAKMKSM
39586229 Caenorhabditis_briggsae PITLDIQAPED--EPIIHE-------ENDWGIEVVDSDTT-----EAPSSSA---------------------ATEVAPGLKFAYEPTQTPKKNSS-DNLKL--SPSQAVTKEWMENIRD
17508819 Caenorhabditis_elegans PVDLEVEVPEE--ETVVHE-------DNEWGIELVNESEP-----SAEQSSS----------------------LNAGTGLKFAYEPIKRDAQTEL-SPAQA--ATHDFMKSIKDKLVEE
91094899 Tribolium_castaneum VVENK--QES---DTPVHE-------DNEWGISLVDESVE-----ND------------------------KGAQNVASGVSLAYAVPDKDIGDVE--VSK---SDDTSLEELMAQMKAI
54642933 Drosophila_pseudoobscura VVQEE--APT---DEPLHA-------SNDWGIELVAEDAP-----SDAPTDL-------------------SQSTDVGQGLRLAYEAPEKSSAEAT-QAATAP-VDDTSLEDLMAQMKSM
24641311 Drosophila_melanogaster LIEEK--AVS---EEPLHA-------TNEWGIELVAEDAP------ESNTTP-------------------AETPVMGEGLRLAYEAPEKSSETSE-ETVSAATADETSLEDLMAQMKSM
118791454 Anopheles_gambiae_str_PEST TAVAA--EEEP--EGPLHE-------DNLYGIELVADDADTAGKSDQQVAAT-------------------TRGSNIAEGLKLAYDAPVVEAETG--QVSV---DNDVSLDELMAQMSGM
108880359 Aedes_aegypti RVEEV--PEE---ETPLHE-------ENLYGIELVAEDDT-----QGSQPST-------------------GTTHSISTGLKLAYEPPASTKHSET-TSTTAV-SDDVSLDELMAQMKSM
47223426 Tetraodon_nigroviridis PKVEVV-QEE---EEVVHE-------ENEWGIELVSEVTD-----TELQAAT-------------------GARPDLKEGITVAYTIP--AKSSAS-GDTVE--DTEQSLEELMARMKNL
68125462 Leishmania_major LYAARKARADRAEKERQAAQARAKACAAEWDITVEAEGKD-----SLAVHSGVAKLAAAGAASSATAAALLGNNEEGESGLEYAYAGTAADNAAVE-DEDKYVKTAGASVEELMARMKAI
71744712 Trypanosoma_brucei_TREU927 LHNAAKHRTEREAKEREAAKARAAASAKEWGIVVEEHGKD-----DLSVNTK-------------------GDT----GGVEYAYGAGGKAEGNAPREDEFVAADSGESLEALMAKMRAM
71408260 Trypanosoma_cruzi_strain_CL_Brener LHQANKQREEREAKERAAARAKATASAAEWGIVIEARGKE-----DLAVHAP-------------------QPEGVEAVSVEYAYSSGAGNAAEHA-QEEFVMTDGGESLEALMAKMKAL
71407292 Trypanosoma_cruzi_strain_CL_Brener LHQANKQREEREAKERAAARAKATASAAEWGIVIEARGKE-----DLAVHAP-------------------QPEGVEAVNVEYAYSSGAGNAAEHA-QEEFVMTDGGESLEALMAKMKAL
118351953 Tetrahymena_thermophila_SB210 RLEQRKKAAK---EAFEKENKPS---ENEWGIEIVDESGP----QSDSNKKD-------------------DDVKEISEQE-----------------------IEQNNLDDLMAKLQNM
115446279 Oryza_sativa_japonica_cultivar_group KMEAEASAAD---ECPVHL-------DNDWNISVVDDSDT-----VTPSILS-------------------TGADSLPEGLVRELPTADSYQEPVA-PVTSG--AIDDDLEELQRQLDAL
15220493 Arabidopsis_thaliana KMEADASTTID--EGPLHD-------DNEWNISVVDDENE-----KDTTKAA-------------------SSSDTLPEGLTRELPVADEYEKAIA-IASGS--GETEEEDDLEDLKKQL
66519020 Apis_mellifera KIKEH--IVE---DTPLHE-------DNEWGISLIDERDQ-----EQVDENK------------------------YLSSVNVKETNCDSHSIDSQ-INQISS-ESNISLEELMAQMKSI
72083934 Strongylocentrotus_purpuratus PSSEVEEIKE---EEVVHE-------ANDWGIELVAETSA-----DDL--VS-------------------KPAPELASGISYAYDKP--AEQQQ-------------------------
66800527 Dictyostelium_discoideum_AX4 PKENLIQNNN---NNNINNNEKKSTYENEWGIELIETSED-----FNNNNNN-------------------NNKPS-NNSFEFSYDKKPTVELNEQ-STVKV--NSSSNLEDLMNQLKNM
68403668 Danio_rerio PKQEVV-QEE---EEVVHE-------DNEWGIELVSEVTE-----AELQDAS-------------------GPIPDLPEGITVAYTIP--EKDGGS-GETVE--ETEQSLEELMAQMKKM
consensus/100% .............................asI.l..p...................................................................................
consensus/95% s..........................s.asI.l..p..........................................sh...b...................................
consensus/90% P............pp.h..........s-WGIpl.scs.........................................ulph.h..s.....................hc.lb.bb..b
consensus/85% P............cp.hp.........N-WGIpllscs.......p.....s.........................s.ulphuY..s....................sl-.Lbsbhp.h
consensus/80% Pb.b.....p...cp.lH........sN-WGIplVs-ssp.....p....ss....................s..phspGlphAYs.s................ss.psL-cLMsbhc.h
consensus/75% Pbpbs..ppp...cp.lHc.......-N-WGIELVsEssp.....pp.p.ss...................ssssslspGlphAYs.s...p.s.....s....ss.pSL--LMAbM+sh
consensus/70% Pbpbs..ppp...-E.lH-.......-NEWGIELVuEss-.....pp.ppss...................ssssslspGlphAYs.s...p.ss....s....ss.pSL--LMAbMKsh
B. Apg7N--Apg7 N-terminal domain
FINAL -------------HHHHHHHHHHHHHH-----------------EEEEEE---------------------EEEEEE-------------------------------------------EEEEE----EEEEE--HHHHH-HHHHH---HHHHHHHHHH---------------------HHHH----EE--H-HHHHHHHHHHHHHH---EEEEEEEE----------EE--------------------EE--------HHHHHH---HHHHHHHH--------EEE-------------------------------EEE----EEEEEEEE-------EEE------EEE--EEEE-----------HHHHHHHHHH-----HHH-------EEEEEEEE--------------EEEEEEE-------------E----------------------EEEEE-E-------------E--EEE------HHHHHHHHHHHHHH--
ALIGN ------------HHHHHHHHHHHHHH------------------EE--------------------------EEEE------------------------------------------------------E-----HHHH---HHHH---HHHHHHHHHH---------------------HHHH-----------HHHHHHHHHHHHHHHHHEEEEE--------------------------------------------HHHHHH---HHHHHHH---------EEE-------------------------------EE------EEEEE------------------EEE--EEE------------HHHHHHHHHH-----HHH-------EEEEEEEE---------------EEEEEE-------------------------------------E-------------------------------HHHHHHHHHHHH---
HMM -EEE-E---EE--HHHHHHHHHH--EEEE--------------EEEEEEE----------------------EEEEE-------------------------------------------EEE-E----EEEEEE-HHHHH-HHHHH---HHHHHHHHHH---------------------HHHHH---EEE-H-HHHHHHHHHHHHHHH--EEEEEEEEEEEEE-----EE--------------------EEEEE------HHHHH---HHHHHHHH-------EEEE-------------------------------EE-----EEEEEEEEE-----EEEEE----EEEE--EEEE----------HHHHHHHHHHH-----HHHHHH----EEEEEEEE--------------EEEEEEE-------------E----------------------EEEEE-E----------EEEE--EEE-----HHHHHHHHHHHHHHH--
FREQ ------------HHHHHHHHHHHHHHH------------------E--------------------------EEEE-----------------------------------------------------EEE----HHHHH-HHHHH---HHHHHHHHHH---------------------HHH-----------HHHHHHHHHHHHHHH---EEEEEE------------E--------------------E--------HHHHHHH---HHHHHHH---------EEE-------------------------------EE-----EEEEEEE--------EE------EEEE--EEE-------------HHHHHHHHH-----HHH-------EEEEEEEE---------------EEEEEE-------------E-------------------------------------------------------HHHHHHHHHHHHH--
PSSM --------------HHHHHHHH----------------------EEEEE----------------------EEEEE--------------------------------------------EEEEE----EEEEE--HHHHH-----H---HHHHHHHHHH---------------------HHH------H--H-HHHHHHHHHHH------EEEEEEE--------------------------------------------HHHHH---HHHHHHHHH-------EEE-------------------------------EEE----EEEEEEEE-----------------EE--EEEE-----------HHHHHHHHHH-----HHH-------EEEEEEEE--------------EEEEEEE------------------------------------EEEEE------------------EEE------HHHHHHHHHH------
108874051 Aedes_aegypti LKFV-PPKSFVHHDFWYKLADIKLHIDKLVDSA---------KNVYAFVT------------DFE---RSKLLVEVDCTSFNSE-----------------------------QTISSSYFNCHG----ILLNKNTIEEFK-GTDKN---DLLKRTSDNY---------------------MKQLLFKDKLGHS-SEIFFFILFSYADFKAHKYYYWFAFPALRDVVYSCPK--------------------EQQLLSSHFPDDLLDR---FKEQMQAFQ-RMAAELVFL-------------------------------YDKSNNAILKLSNLVCHNHKEDNFKDINLDNTYI--CCEDRS---VDENPSWFLRQLLGYL-----VFTCPQLADKDIKFICLRQ----------TLQTSLVLHV-------------TIPGT-----------DYSIESSLWTGW-EANENGK----LVPR--LADMSNVMDPQILAERSITLNLTLM
118790306 Anopheles_gambiae_str_PEST LKFL-PFQSFIHNDFWHKYVDIKIDIDRLNETG---------RTIIGTIA------------LRK---NKVPMVEVTCSSLNTK----------------------------YEDDSVLGFRCKG----ILLNHNTLETFK-NCDKK---ALLKIEAIKL---------------------YSDLLNQESIQSS-SDLVKFCLLSFADLKKYKFYHWFAFPAPTELIFKYDD--------------------EKTITS--ISEERLRS---CIVQFLYRK-PTPNEPFFI--------------------------------YHVNEGIKLISEYIQHHNKLANFREQDLNNLYF--CCYDPSGQNISSPPGWQLRQFLTYL-----VITSP--ALAEQGIKCIRITG--------GTASELQFSE---------MRIFLPKHV-----------SNVNSLSSWVGW-ESDESGK----YLPR--LTTLNNSMSPKRLAENAINLNLKLM
19112876 Schizosaccharomyces_pombe_972h_ LQFQ-SFHSSIDATFWHQLSNYKVEKQKLDASP---------LTIHGKFN--------------T---YSRGNISIVFGEAPSN-------------------------------SNIKDCLAEG----TLLNANTPQEFT-NADVK---KIREEIGEVL---------------------LNSIKNGVVSERP-NELLRFLIFSYADIKAYKYHYWCLFPS-FKETPHWIV---------------KDLSPAESLIP----SGPILS---QIREFLSTA-DYYQRPFFL-------------------------------LIKSTLDEWTIAPL--KELSH---CVDKSLQFYL--VAEDSV--QLAEYPSWPVRNILAFA-----FIKF---KLKVINLFLYRDGINSD-----TLSKSILIKV-------------EADKD-----------MILEAPLSIVGW-ERNGKGV----LGPR--VVNLSTVLDPFVLSESASTLNLSLM
56754857 Schistosoma_japonicum LQYI-PFETVVDTAFWHSLADRKLSEYRLSEGP---------FKISAQFT----------NSHAL---GVSPRLSVDVTSFCDT--------------------------NVKRSHSSTSFKISG----DLFSLNSLDEFK-NIDKQ---LFLNEYGTKF--------------------MTKALSENKFLKKP-ELLLRFLLLTYCDLKKHKFYFWFAYPAVLHSVQPIVT---------------CTRSIDKEFSK--DQLVHILH---SFDCWRK----ENTSPFFV---------------------------------LKCGSSINVVPL--SDFEL-------APDVYV--GMCDSS--VDAHSPCWLLRNLLYAL-----SATVIH-SEYPLKILCFRDRFVSGQR---HWQHSIVIHI---------------NIL-----------PTSLSFTQFVGW-EKWKNK-----LKPR--VVDLSSSMGP---------------
17541546 Caenorhabditis_elegans --FV-PFVTCLDTGFWNEVNKKKLNDWKLDETP---------KCISSQLS----------LHQTE---GFKCHLSLSYDSLSSL-------------------------------ESTTGLSMSG----TLLLYNTIESFK-MVDKS---DLIRSEAEKI---------------------WESITTRKWLQNP-RLLSQFFIIAFADLKKFKYYYWTCVPA-LVYPSEIK-----------------------------QEITPLSSLGADHKILFDFY-RKNNFPIFL-------------------------------YSKQSSKMLELSEL---------ENNTNPDEICV--VVADPS--PVAYSAGWMVRNVLAAV-----AHLHP--TWKHCHIISLRSAD--------SIGIKYTWTL----------PSAECSAD-----------GAQNAVPKAVGW-ERNANDK----LQPI--SVDLSKEFDPKILMERSVDLNLSLI
39593701 Caenorhabditis_briggsae --FV-SFKTYLDTPFWREVNKRKLHEWKLDETP---------KPIFSQLS----------LCERN---SDHCRLSLSHDSFKPS------------------------------NGNPNEVSISG----NLILYNTRESFKAAATTKSLEELMKTEATKI---------------------WDVITTKTWLQTP-HLLSSFTIIAFADLKKFHYIYKTFIPS-LKYPKNPE-----------------------------QEIPSLST---DESSLLTYY-KRTLAPVFL-------------------------------FSKSSQEPLEIAHL---------ESQVNPDDVLI--VVADPS--PNPSSAGRLVKNVVAAV-----AYLHS--SWDHCNVISLRSSG--------SIEIKYSWPA--------------NADA-----------VAQNVVPQCSGW-EQHY-------------SADLSKQFDPKIMMEEAVNLNLSLI
19922550 Drosophila_melanogaster LQFA-PWESFVSPTFWHKLAELKLDHDRLSDSK---------RSITGHYT------------NRN---ASGCLLEVDYTAYNRM-----------------------------AKPPKFSHSAIG----TIYNKNTIEEFK-ALDKL---QLLADEGKEL---------------------LADMCSGGALRDP-SLLTRFFVLSFADLKCHSYYYWFAFPC--PLTPTLKL-----------------QGAVQKLRDLPNSSSYIMA--------LKAL-PTESQNFFI-----------------------------------LYANVEKNIF--EARSLSSLDDKNVEFCYF--GFADPS--EY-EHPAWIMRNYAAFL-----LQQCPSFVGKPLKFLGLRHNQQM------NIDDSLVWKV-----------IQTEACD-----------LSQSENIKFVGW-ELNKNGK----MGPR--MVCMRDSMDPAKLAENSVNLNLKLM
66824909 Dictyostelium_discoideum_AX4 LQFK-EFSSFVNISFWHELSNKKLDELKLSEES---------IPLNGHYT----------FSPSQ---QLDPFLCLEFNAFLRN--------------------NVTNSTENQYVLPPRSYLSHG----TLYNYNTVDDFK-QSPKI---KLFNDASKRI---------------------WNDINNGNIDKDT-SLLNRFILLTYADIKNHQFYYMFGIPA-LLPSQPIQQ----------------------------FTEKPESI---NIESLKSFS-NQILPQYFCLKQQQQES-----------------------STTTTTSFELIGSI--EEKGNQYLNECLENDLIPLVGFCDPC--SLPLNPGWPLRNFLIYL-----SIKYP--MLKKIKVLCYRGNG--------STSNSILLSL--ELPSMGEQLIKKQQEE-----------DAGEWSGKSVGW-EKDSNGK----IAPR--FVSLASTMDPLKLAEQSVDLNLKLM
115760330 Strongylocentrotus_purpuratus LQFA-PFSSALDVGFWHKLTQKKLNEYKLDDGP---------KDIYGYYY----------NGDPD---GLPCRLSLEFNAFDQS-----------------------------ETTPPHCFSSRG----TLVNFNTLDAFK-TCDKK---ALLDVTAEQL---------------------WDDIRQGSAIQDP-SLLSRFRLLTFADLKKYHYCYWFAFPA-LLAPEGTKL-------------IQPPEKLDKAMDQ--DKITALQA---AYDLASQSL--GQEPAFFL--------------------------------ISTEDDKTVVLPL--TAWDQ----VTDKSKVMF--GYADPC--TLEQYPGWPLRNFLCLI-----SCHWAS-QLDQVTVVCFRNRTREGIR---NSSHSLILRL-------------QVPST-----------SPEISCPKCVGW-EKNQRNK----LGAR--KVDLSSSMDPTRLAETSVDLNLKLM
71895443 Gallus_gallus LQFA-PFSSALNVGFWHELTQKKLNEYRLDETP---------KVIKGYYY----------NGDPS---GFPARLTLEYSAFDIN-----------------------------ASIPARCCPAFG----TLYNTNTFETFK-SCDKK---SLLEKEANEI---------------------WESIKSGAALENP-MLLNRFLLLTFADLKKYHFYYWFCYPA-LCFPDGIHV-------------IQKPVCLGDRFSL--NQIQALQK---AYDELCQTE-GVTAFPYFL--------------------------------IKYHDNSVVVSPL--KKWDG--FFQDQGGKVTV--GVYDPC--NLSHYPGWPLRNFLILA-----SHKWGN-ILQSIEVLCFRDRTMQGVR---DITHSIIFEI-------------KLPQG-----------AFGPDCPKAVGW-EKNQKGG----MGPR--VVNLSECMDPKRLAESSVDLNLKLM
58865764 Rattus_norvegicus LQFA-PFNSALDVGFWHELTQKKLNEYRLDEAP---------KDIKGYYY----------NGDSA---GLPTRLTLEFSAFDMS-----------------------------APTPARCCPAMG----TLHNTNTLEAFK-TADKK---LLLEQSANEI---------------------WEAIKSGAALENP-MLLNKFLLLTFADLKKYHFYYWFCCPA-LCLPESIPL-------------IRGPVGLDQRLSP--KQIQALEH---AYDDLCRTE-GVTALPYFL--------------------------------FKYDDDTVLVSLL--KHYSD--FFQGQRTKLTV--GVYDPC--NLTQHPGWPLRNFLVLA-----AHRWSG-SFQSVEVLCFRDRTMQGAR---DVTHSIIFEV-------------KLPEM-----------AFSPDCPKAVGW-EKNQKGG----MGPR--MVNLSGCMDPKRLAESSVDLNLKLM
74179095 Mus_musculus LQFA-PFNSALDVGFWHELTQKKLNEYRLDEAP---------KDIKGYYY----------NGDSA---GLPTRLTLEFSAFDMS-----------------------------ASTPAHCCPAMG----TLHNTNTLEAFK-TADKK---LLLEQSANEI---------------------WEAIKSGAALENP-MLLNKFLLLTFADLKKYHFYYWFCCPA-LCLPESIPL-------------IRGPVSLDQRLSP--KQIQALEH---AYDDLCRAE-GVTALPYFL--------------------------------FKYDDDTVLVSLL--KHYSD--FFQGQRTKITV--GVYDPC--NLAQYPGWPLRNFLVLA-----AHRWSG-SFQSVEVLCFRDHTMQGAR---DVTHSIIFEV-------------KLPEM-----------AFSPDCPKAVGW-EKNQKGG----MGPR--MVNLSGCMDPKRLAESSVDLNLKLM
74141573 Mus_musculus LQFA-PFNSALDVGFWHELTQKKLNEYRLDEAP---------KDIKGYYY----------NGDSA---GLPTRLTLEFSAFDMS-----------------------------ASTPAHCCPAMG----TLHNTNTLEAFK-TADKK---LLLEQSANEI---------------------WEAIKSGAALENP-MLLNKFLLLTFADLKKYHFYYWFCCPA-LCLPESIPL-------------IRGPVSLDQRLSP--KQIQALEH---AYDDLCRAE-GVTALPYFL--------------------------------FKYDDDTVLVSLL--KHYSD--FFQGQRTKITV--GVYDPC--NLAQYPGWPLRNFLVLA-----AHRWSG-SFQSVEVLCFRDRTMQGAR---DVTHSIIFEV-------------KLPEM-----------AFSPDCPKAVGW-EKNQKGG----MGPR--MVNLSGCMDPKRLAESSVDLNLKLM
73984602 Canis_familiaris LLFA-PFSSALDVGFWHELTQRKLNEYRLDEAP---------KDIKGYYY----------NGDSA---GLPARLTLEFSAFDMS-----------------------------APTPAHCCPAVG----TLFNTNTLEAFK-AADKK---LLLEQAADEI---------------------WEAIKSGAALENP-VLLNKFLLLTFADLKKYHFYYWFCFPA-LCLPESIPL-------------IQGPVGLDQRFSP--KQIQALEH---AYDDLCQTE-GVPALPYFL--------------------------------IKYDENMVLVSLL--KHYSD--FFQDQRTKITI--GVYDPC--NLAQHPGWPLRNLLVLA-----AHRWSS-CFQSVEVLCFRDRTMQGMR---DIAHSIIFEV-------------KLPEM-----------AFSPDCPKAVGW-EKNQKGG----MGPR--MVNLSECMDPKRLAESSVDLNLKLM
5453668 Homo_sapiens LQFA-PFSSALDVGFWHELTQKKLNEYRLDEAP---------KDIKGYYY----------NGDSA---GLPARLTLEFSAFDMS-----------------------------APTPARCCPAIG----TLYNTNTLESFK-TADKK---LLLEQAANEI---------------------WESIKSGTALENP-VLLNKFLLLTFADLKKYHFYYWFCYPA-LCLPESLPL-------------IQGPVGLDQRFSL--KQIEALEC---AYDNLCQTE-GVTALPYFL--------------------------------IKYDENMVLVSLL--KHYSD--FFQGQRTKITI--GVYDPC--NLAQYPGWPLRNFLVLA-----AHRWSS-SFQSVEVVCFRDRTMQGAR---DVAHSIIFEV-------------KLPEM-----------AFSPDCPKAVGW-EKNQKGG----MGPR--MVNLSECMDPKRLAESSVDLNLKLM
109034365 Macaca_mulatta LQFA-PFSSALDVGFWHELTQKKLNEYRLDEAP---------KDIKGYYY----------NGDSA---GLPARLTLEFSAFDMS-----------------------------APTPARCCPAVG----TLYNTNTLESFK-TADKK---LLLEQAANEI---------------------WESIKSGTALENP-VLLNKFLLLTFADLKKYHFYYWFCYPA-LCLPESLPL-------------IQGPVGLDQRFSL--KQIEALEC---AYDNLCQTE-GVTALPYFL--------------------------------IKYDENTVLVSLL--KHYSD--FFQGQRMKITI--GVYDPC--NLAQYPGWPLRNFLVLA-----AHRWSS-SFQSVEVLCFRDRTMQGAR---DVAHSIIFEV-------------KLPEM-----------AFSPDCPKAVGW-EKNQKGG----MGPR--MVNLSECMDPKRLAESSVDLNLKLM
18422607 Arabidopsis_thaliana LQFA-PLNSSVDEGFWHSFSSLKLDKLGIDDSP---------ISITGFYG----------PCGHP---QVSNHLTLLSESLPLD---------------------EQSLIASTSHGNRNKCPVPG----ILYNTNTVESFN-KLDKQ---SLLKAEANKI---------------------WEDIQSGKALEDP-SVLPRFLVISFADLKKWSFRYWFAFPA-FVLDPPVSL--------------IELKPASEYFSS--EEAESVSA---ACNDWRDSD-LTTDVPFFL-------------------------------VSVSSDSKASIRHL--KDLEA---CQGDHQKLLF--GFYDPC--HLPSNPGWPLRNYLALI-----RSRW---NLETVWFFCYRESRGFA-----DLNLSLVGQA-----------SITLSSG-----------ESAETVPNSVGW-ELN-KGK----RVPR--SISLANSMDPTRLAVSAVDLNLKLM
9758937 Arabidopsis_thaliana LQFA-PLNSSVDEGFWHSFSSLKLDKLGIDDSP---------ISITESLP-------------------------LDEQSLIAS----------------------------TSHGNRNKCPVPG----ILYNTNTVESFN-KLDKQ---SLLKAEANKI---------------------WEDIQSGKALEDP-SVLPRFLVISFADLKKWSFRYWFAFPA-FVLDPPVSL--------------IELKPASEYFSS--EEAESVSA---ACNDWRDSD-LTTDVPFFL-------------------------------VSVSSDSKASIRHL--KDLEA---CQGDHQKLLF--GFYDPC--HLPSNPGWPLRNYLALI-----RSRW---NLETVWFFCYRESRGFA-----DLNLSLVGQA-----------SITLSSG-----------ESAETVPNSVGW-ELN-KGK----RVPR--SISLANSMDPTRLAVSAVDLNLKLM
125571171 Oryza_sativa_japonica_cultivar_group -----------ETGFWDALRRLKLDVLGTDDSP---------IPITGANP----------SSSSP----TFAFVVLSSDVF----------------------------------FPPKTCRLER----GTGSVRIP-----ASPRL---PPWNSDAVVI---------------------LHDIKSGKVEENP-ALLLRFLVISFADLKNWKVYYNVAFPS-LIFDSKITL--------------LSLKLASQVLKQ--EEATSLSN---AFTEWRKSS-ETTVVPFFL-------------------------------INISPDSSATIRQL--KDWKA---CQGNGQKLLF--GFYDHG---NRGFPGWALRNYIAFV-----SLRW---KIEKVHFFCYREKRGRP-----DIQQSLVGEA----------SFPAPHGW-----------DEPDYVPEAIGW-EGETAGKESKEMKPK--EIDLSS-INPASQDEEKQLMHLKLM
115438558 Oryza_sativa_japonica_cultivar_group -----------ETGFWDALRRLKLDVLGTDDSP---------IPITGYYT----------PRQYE---KIASLFRICPESILPP--------------------------SANSFGDRNNCPVPG----TLLNTNNMRGFQ-NLDRA---LLLKAEAKKI---------------------LHDIKSGKVEENP-ALLLRFLVISFADLKNWKVYYNVAFPS-LIFDSKITL--------------LSLKLASQVLKQ--EEATSLSN---AFTEWRKSS-ETTVVPFFL-------------------------------INISPDSSATIRQL--KDWKA---CQGNGQKLLF--GFYDHG---NRGFPGWALRNYIAFV-----SLRW---KIEKVHFFCYREKRGRP-----DIQQSLVGEA---------SFPAPHAGW-----------DEPDYVPEAIGW-EGETAGKESKEMKPK--EIDLSS-INPASQDEEKQLMHLKLM
125526846 Oryza_sativa_indica_cultivar_group -----------ETGFWDALRRLKLDVLGTDDSP---------IPITGYYT----------PRQYE---KIASLFRICPESILPP--------------------------SANSFGDRNNCPVPG----TLLNTNNMRGFQ-NLDRA---LLLKAEAKKI---------------------LHDIKSGKVEENP-ALLLRFLVISFADLKNWKVYYNVAFPS-LIFDSKITL--------------LSLKLASQVLKQ--EEATSLSN---AFTEWRKSS-ETTVVPFFL-------------------------------INISPDSSATIRQL--KDWKA---CQGNGQKLLF--GFYDHG---NRGFPGWALRNYIAFV-----SLRW---KIEKVHFFCYREKRGRP-----DIQQSLVGEA----------SFPAPHGW-----------DEPDYVPEAIGW-EGETAGKESKEMKPK--EIDLSS-INPASQDEEKQLMHLKLM
111056666 Phaeosphaeria_nodorum_SN15 LKFA-PWQSDVDIQFYAALAHIKINHDMLDDSA---------RKILGLYE--------VRPGEHA---TRSMRVQIHPNALTSD------------------------------DAPPTYCRAEG----IIKNCNTIEDYK-NLDRA---AILERCAQTI---------------------WEAIHDGSIYECP-SLLSSFTAIIFANLKKYKFTYHFAFPA-IQSDPPWKQ-----------------VGEMTRLHA--RETTYLVD---AVQTWRYSS-DVRQRGFFLAKRIRGGGNPDERPKTPVT------------PLEEFGYTWAIGKL--EQFEKGFFNGVNKEDQLI--CFADPS--TYESNPGWPLRNLLVLL-----RHKW---HLSEAQIMCYRDTHMKR-----DQSNSIILQL-QADASTTQSGPEVPNER-----------PRTPQLPKVTGW-ERTEAGK----LSSR--NVDLSEYMDERKLADQAVDLNLKLI
119184970 Coccidioides_immitis_RS MQYT-PFISDIEIPFFSSLATLKLNHDKLDDSI---------HNILGFYE--------VRPSDPQ---EVSCRMQVPGNALVADKWVL-------------LKWSKGSFIDLPFRVPFGAFRAEG----VIKNFNTAEEYR-IVDKS---AMLHDAGKRI---------------------WDAIMDGSVYSSP-SLLASFLMLSFADLKKYRFSYWFAFPA-IHSNPPWVPSPVHHDSRDLDKSENAIHQSSFSLTN--SDRDALVD---AVLAWRSTV-EPRQHGFFLARRVRHLPSQPQLESNIPTDPGSNASPLQAPDYNKCNCTWEVSSL--STYENGFFGNAAAEDCFI--CFVDPS--NYPDAPGWMLRNLLILI-----RHKW---RLNKVQIIRYREIPSFA-----MGPQSTVMIL------KSDTSIDDSFSR-----------SGSLVMPKLSGW-ERNAN-----------------EHMDPERIADQSVDLNLKLM
119480443 Neosartorya_fischeri_NRRL_181 MQYA-PFASDIELPFYTALATLKIDRDKLDDSA---------RKVLGLYE--------LRSTDAP---NNSCRMQIHGNALTSD------------------------------DVPEGYYRAEG----TIKNFNTFEEYR-DIDKP---QMLQQAGQTI---------------------RDAIEDGSIYLCP-SKLSSFMILSFADLKKYKFHYWFAFPA-LHSTPSWTPVPYSGEIVGDTPVEPINRAPFKALST--LESSTLVE---AVQTWSRSV-EACQRGFFLARKYFKLDGRPGHDAKGMPETADGTLVAS--SQQSAGHNWKIASL--ASYESGFFDGAPFEDSFI--CFADPS--NYDDAPGWMLRNLLFLI-----KQRW---GLRRAQILRYRDTRR-------ENGRSMVVTMEC----KAQPVSHPGSSP-----------ETVSGAPKVTGW-ERNSAGK----LSGR--LVDLTEYMNPKRLADQSVDLNLKLM
70989809 Aspergillus_fumigatus_Af293 MQYA-PFASDIELPFYTALATLKIDRDKLDDSA---------RKVLGLYE--------VRSTDAP---KNSCRMQIHGNALTSD-------------------------------------EAEG----SIKNFNTCEEYR-DIDKP---QMLQQAGQTI---------------------LDAIEDGSIYLCP-SKLSYFMILSFADLKKYKFHYWFAFPA-LHSTPSWTPVPYSEEIVGDTPVEPINRSPFKALST--LESSTLVE---AVQTWSRSV-EACQRGFFLARKYPKLDGRPEHDSKEMTKIADGTLVAS--SQQSAGHNWEIASL--ASYESGFFDGVPFEDSFI--CFADPS--NYDDAPGWMLRNLLFLI-----KQRW---GLRRAQILRYRDTRC-------ENGRSMVVTMEC----KGQLVSRPGSFP-----------ETVSGAPKVTGW-ERNSAGK----LSGR--LVDLTEYLNPKRLADQSVDLNLKLM
121715192 Aspergillus_clavatus_NRRL_1 MQYA-PFASDIELPFYTALASLKINRDKLDDSA---------RKVLGLYE--------LRPADPP---NNSCRMQIHGNALISD------------------------------EVPAGYYRAEG----TIKNLNTIEEYR-NIDKS---QVLQQAGKMI---------------------WNAIEDGSIYLCP-SLLSSFIILSYADLKKYKFHYWFAFPA-LHSEPPWTP--DTVTSKGVESHIQTRSEALAFLSS--AEDSTLSE---AVQAWARGV-RAHERGFFLAKRSRTSGDNVGPNIEGDARNINNP------SPRISDHIWEIDSL--AAYESGFFEDADSDDCFL--GFVDPS--NFDNAPGWMLRNLLVLV-----KQRW---GLQRVQILRYRDTIR-------GKGRSMILTM---------KQKEQAPLE-----------TAINDMPKVTGW-ERNTAGK----LTGR--LVDLTEYLDPRRLADQSVDLNLKLM
115398409 Aspergillus_terreus_NIH2624 MQYT-PFASDIELPFYTALASLKINHDKLDDAA---------RKLLGLYE--------IRLSDPP---NASCRMQIHGNALTSD---------------------------------------------E------------NMDKT---HMLQQAGQTI---------------------WDAINDGTIFSCP-SLLSSFIVLSYADLKRYKFHYWFAFPA-LHSDPSWSPLS------AASDKSADGDAPTRTLSS--EESSTLVE---AVQTWSYSV-DARQRGFFLARKCPRGGSQSRTHGQAGGEGAEG-------SQAQGNISWKVAPL--SSFEEGFFEDASFEDSFV--CFVDPS--NYPSAPGWMLRNLLALV-----KYRW---KQNKVQILRYRDIHSKR-----DQPHSAVMVL---ESKAPQRDSNATAAG-----------SSAEAMPKVTGW-ERNPAGK----LTGR--LIDLTEYLDPKRLADQSVDLNLKLM
83767092 Aspergillus_oryzae MQYT-PFASDIELPFYTALASLKINHDKLDDSA---------RKIMGLYE--------IRSTDPP---SSSCRMQIHGNALTSD------------------------------EVPAGFYRAEG----LIKNVNTIEEYR-NADKT---LLLCSSGRMVSLTTHGILQGNNDTI------WDAIKDGTIYSCP-SLLSSFAVLSYADLKRYKFHYWFAFPA-IHSDPPWAP-LGATGDTSHSKSSEREYVPFVYLSS--AESSTLVE---AVHTWGYGT-DARQRGFFLARRILATSGKAYKDPTKHTGSKPGKDK----AADAEGACWRIAAL--SDYENGFFDGANFEDCYV--CFVDPS--NYENAPGWMLRNLLVLV-----KHRW---GLSKIQVLRYRDVHSKR-----DQGRSIVVTL-------AEKNQPTLDLK-----------APDHIMPKVTGW-ERNPTGK----LTGR--LVDLTEYLDPQRLADQSVDLNLKLM
67900882 Aspergillus_nidulans_FGSC_A4 MQYT-PFASDIELPFYIALASLKINHDKLDDSA---------RKVLGLYE--------LRPSDAP---NASCRIQIHGNALTSD------------------------------EVPSTYYRAEG----MIKNVNTIEEYA-KADKM---GMLQQSGETI---------------------WNAINNGTIYSCP-SLLSAFVILSYADLKKYKFHYWFAFPA-LHSDPSWTP-----------LEEGCEGAQAHRLPS--VESSALAR---SVQEWARVV-DAPQRGFFLARRVR--------------------------MRDDDTVSWKIASL--SSYEDGFFKHAEFADCFT--CFVDPS--NYEEAPGWMLRNLLVLV-----KRRW---GLTKVQILRYRDGPSPR-----DCGRSIVVTL-------RLKTSQLPDGG-----------VKDDRMPKVTGW-ERNPS-------------------------ADQSVDLNLKLM
39971963 Magnaporthe_grisea_70_15 LQFA-PFESQIEMPFYSALFSRKLDHDKLDDSV---------RPVIGLYQ--------PMSERPP---AESTRMQIQGGALSSS--------------------------QPIVSVPMGYTRADG----SIRNFNTIEDFK-KADKG---AILRQAGAQI---------------------WDAIKDGSIYEIP-SLLSSFAILSYADLKKYRFTYWFAYPT-LHSVPAWRR-----------------DGPLARFSS--KETTALVN---EVGTFRYAH-DTRQHGFFLAKKVPYRSGPFRRGLPRDDS-----------DGDDIGFTWSIGAL--GEFEKGFFKGIKEEDQYI--AFVDSS--SYAENPSWPLRNLLVLI-----RQRF---QLQKANILCYRDTQARR-----DEPRSIVLPL-----------ASEGPAT-----------PQTSEMPKVTGW-ERHPSSK----LQAR--VISLAEYMDPTRIADQAVDLNLKLM
46137421 Gibberella_zeae_PH_1 LQFA-PFISEIELPFYSALFASKLDHDKLDDSA---------RSVLGLYE---------PRSEEP---ESSCRLQILGNALTSG-------------------------KTNEPSSPLATMRAEG----IIRNVNTLEDFK-NTDKP---AMLRTAGRQV---------------------WDAIKDGSIYSVP-SLLSSFIILSYADLKKYKFTYWFAFPA-LHSDPVWKR-----------------SGPAERLTS--QETTALVD---RVGTWRYSV-DARERGFFLAKKVPGRRETDDPD-----------------TPQELPFHWEIGSL--RDFETGFFDQVPEEDRYV--AFTDPS--TYPEAPGWPLRNFLILI-----RHRF---RLTKTKVICYRDTWAKR-----HEAKSVILTI-----------EMDPVEN-----------LDITEMPKVTGW-ARSSNGK----LQAQ--QVNLGEYMDPARLADSSVDLNLKLM
85100195 Neurospora_crassa_OR74A LKFA-TFSSEIELPFYSALFSSKLDHDKLDSSA---------RPVLGLYE--------PRSHASP---EASTRMQILGSALTSD---------------------------QDESGPLGMTRAEG----YIKNVNTIEEFK-NTDKN---AMIKKAGEQI---------------------WDAIQDGTIYSCP-SLLASFRILSYADLKKYKFTYWFAFPA-LHSEPQWKR-----------------TGPIGRLTS--DESTALVE---RIGTWRYMV-DRREHGFFLAKKVRREAAGPRSSLDD--------------PGVDIGYRWDIGSL--RDFETGFFNDAAEEDRYV--AFVDPS--NYPEYPSWPLRNLLILI-----RQRY---RLNKVQILCYRDTQPRR-----HEARSTILPL-----------AMDQVGD-----------VELKCMPKVTGW-ERNGNGD----LRPR--VANLAEYMDPTRLADQAVDLNLKLM
71021593 Ustilago_maydis_521 LKFV-PFSTNIHPTFWQELSSLKIDKLQLSDDA---------VAIHAHYT-AGKVVLDRQTGESV---SLGSQISLDAASLQSDMSHDSISF--------RSTSCSAVTSLSAVQQSCPGIAARG----FLQNFNTIESFR-NADKQ---FIFDNTVRGI---------------------WKGLTDEQ--QDPEVFLTTFLALTFADLKKFKFYYWFAYPA-LTTNPPWEV-------------IDDAEGVDKVWKPISTQLNEVDY--SVIASWVQQQ-SVR-RGFFL-------------------------------FKAAVGKVGQCGRI--STYAS-FFDGVAESERYV--GFVDPS--GTSQTPGWPLRNLLAYL-----HARF---GVEEAQVICWKDEIANAASGLTFGQTRSVFGKVRLPVSNTTDGVSTMGLELDGRRTRLTCKQNNVQLPNGVGW-ERNAQGK----LAPK--VADLGPLMDPRKLADQAVDLNLKLM
50256724 Cryptococcus_neoformans_var_neoformans_B_3501A LQFQ-PLASQPTPAFWAALAAHKLNHLKLDDSH---------LPITAQIEPAKRVLINKERVDDTADVGIDGSLVVGGDAFEAE----------------------------RGRLPPNAVSVTG----TLKIFNTIEEFKDTSAKK---RLFDDLVSQM---------------------LESFDTDRPVLNP------FLLVTFADLKKYVYHYWFAFPA-LVSSPAWVM-D--------------------------GEFMPVDEIE-DIRNLAQSH-FQHNTAAFL--------------------------------LKGAAPHLSAAPL--SSCST-FYDKTQSEMVTV--VFHDTS--SLPSNPGWGLRNVLYYL-----SAKH---GITSLVVICLRGG---------SSSTQASLSL-------------SSPPS-----------TAPAKPPQAVGW-ERHPSGK----LSPR--VADLGPMMDPTRLAAQAVDLNLKLI
58271168 Cryptococcus_neoformans_var_neoformans_JEC21 LQFQ-PLASQPTPAFWAALAAHKLNHLKLDDSH---------LPITAQIEPAKRVLINKERVDDTADVGIDGSLVVGGDAFEAE----------------------------RGRLPPNAVSVTG----TLKIFNTIEEFKDTSAKK---RLFDDLVSQM---------------------LESFDTDRPVLNP------FLLVTFADLKKYVYHYWFAFPA-LVSSPAWVM---------------------------DGEFMPVDEIE-DIRKLAQSH-FQHNTTAFL--------------------------------LKGAAPHLSAAPL--SSCST-FYDKTQSEMVTV--VFHDTS--SLPSNPGWGLRNVLYYL-----SAKH---GITSLVVICLREG---------SSSTQASLSL-------------SSPPS-----------TAPAKPPQAVGW-ERHPSGK----LSPR--VADLGPMMDPTRLAAQAVDLNLKLI
116498151 Coprinopsis_cinerea_okayama7#130 IQFS-PFSSVVSPAFWHKLTELKIDVLRLSDAP---------LTISGTYT-AGRSIVDRETGQEV---VLPCSFGVEGESFEVSGVTGVGV---------GTGGVGGVSVGEGGGRRKGTVKVQG----TFKNFNTIEEFK-SSDKT---ALFNEEAQKI---------------------WTSILTTKSTKEL----TRFFLISFADLKKYKYYYWFGFPA-FVAKPAWEI------------GSEGWKSAKERFSA--DQLSSIDA-------------QIKDRPFFL-------------------------------VAGTPNGDYTVGNV--EDYET-FFKGVATENRII--GFIDPS--ADPANPGWPLRNLLAYL-----RALHPE-STSELTVLRWRDT---------QNSKLGVVTL---------NVEGTSNAT-----------PSVDERPSAVGW-ERNPQGK----LGAR--LADLGPMMDPTRLAAQAVDLNLKLM
45190901 Ashbya_gossypii_ATCC_10895 LKFAPPFQSFVDASFFQVFSRLKLDVLRLDSHE---------LPLHAKVD--------LAGLARG---SSISHVFLDSQSFDEA------------------------------TASLPGISLRG----SFFNFNTLEEFK-RLDKG---RFLSEQAQLL---------------------WEAGVNGYLDEAA-----GFFVICFADLKKYRFYYWFATPC--------------------------------------FQPETLEL---KVVKREALT-EIDKFSNFI-----------------------------------EQNKILCGVL-NEETGEVIRASRHELERYSTLVVRDTS--NIEHCPTSLVKNFVAVW-----RHHNP--NRSECRVLLLRE----------TCSFSLELSV---------------TGD-----------AMSTSQLKASGW-ERNVRGL----LTPK--ISELGAIIDPTKLAEQSIDLNLKLM
50289851 Candida_glabrata_CBS_138 LLYVSPVESFVDTSFFQELSRLKLDIHGLSTSQ---------ITIHSYLD--------LKNIPSV---SSACHLFLDQQSFNSE----------------------------DICASSERVRLEG----KLYNCNSLEEFK-SLDKQ---QYLAEQGQKIY--------------------TKALED--INSAI-----GFSIISFADLKKYVFYYWVCTPL-FQHE---------------------------------NQQISILD---GPEDIDASF-NDKAKVWFT----------------------------------NHYSNWVAIVL--ENGDINEYTKGLNTSSIRGLLIRDTS--NKQDMPSAFLRNFITIF-----SLDYP--EAKELDVFLMRS----------STIKSIKLRI---------------RLS-----------ETEHTKLKFSGW-ERNSLSK----LMPR--AVDLSALIDPLKVAEQSVDLNLKLM
6321965 Saccharomyces_cerevisiae LSYAPAFKSFLDTSFFQELSRLKLDVLKLDSTC---------QPLTVNLD--------LHNIPKS---ADQVPLFLTNRSFEKH-----------------------------NNKRTNEVPLQG----SIFNFNVLDEFK-NLDKQ---LFLHQRALECW--------------------EDGIKD--INKCV-----SFVIISFADLKKYRFYYWLGVPC-FQRPSSTVL--------------------------HVRPEPSLKGLFSKCQKWFDVN----------------------------------------------YSKWVCILD--ADDEIVNYDKCIIRKTKV-LAIRDTS--TMENVPSALTKNFLSVL-----QYDVP--DLIDFKLLIIRQNEG-------SFALNATFAS-------------IDPQS-----------SSSNPDMKVSGW-ERNVQGK----LAPR--VVDLSSLLDPLKIADQSVDLNLKLM
50302581 Kluyveromyces_lactis_NRRL_Y_1140 LKFSPAFKSFVDTSFFHELSRLKLEVFKLDSAE---------KELFSALD----------LENIT---SNTVSLSLRDDSFDPV-------------------------------LNNEAVTLKG----SVLNFNTIESFK-SCDKV---KFIKEKGQQLL--------------------EQGLKNG-LKECV-----RFYVISFADLKKYKFYYWVCMPTFQSEGSSYEI----------------------------ISTKSIED--------GVKK-DIWEQNSFI-------------------------------------SCVVDGKI--QEASPQYLKVCQKV------IFKDFS--RLKGIPAAVTKNFLTV------WSQIS--TRNTYTICFLR-----------DDNSSFAAEI---------------RVT-----------GSNTGCLKVSGW-EKNGLGK----LAPK--SADLSSLMDPVKIAEQSIDLNLKLM
50549137 Yarrowia_lipolytica_CLIB122 MSFT-PFSSFLEASFFQTLAAKKLNEYKLDDSP---------KRVSAEYT------------------WQQGRLVFDSDSFSDR-----------------------------DSHCKGVVECPG----TLLNYNTIEEFK-GADKK---ALLAEWGDKML--------------------SGAIMNGSIFRNP-EILNSFLLITFCDLKKYIFVYWMGVPC---LNTKWDL-----------------------------QEVADEG---NYTNLSTRI-PALGESFVV--------------------------------IDPDDNVTPFSEL---------EYVERSEDPTI--AFLSPT--SPENTPWT-VRNICLML-----HILG---FKSATMILVGR-----------EKNRFLEWK------------------------------RGDGELGAWTGW-EKNSAGK----LLPK--QTNLGPLLNPLQLASQAVDLNLKLM
62899676 Pichia_pastoris IPYS-QISSFVNSSFFQKVSQLKLNKYRLDDTD---------KAIVGSVD---------FKFIGK---NQPTSLSVDESSFNDN-----------------------------ITYTHAQFPVKG----ILKNLNTVEDFR-KVDKN---EFLQSQGLVV---------------------HKSIQDRSCLKDL-SKLTQFFILSFSDLKGFKFIYWFGFPS---LVSRWKV--------------------NKLSGLTESQIEPYES---KLNEWLNARLPIEQKQAFI------------------------------------IDNLEFKPF--EQLSS----FSPDDQLNI--GFIDTS--SILNKCSTQLRNILYML-----AYY----GFENIKVYNFRF----------NNTTSFTLDI---------------TLA-----------EPLTSEPKTTGW-ERTAQGK----LGPK--LADIGALVDPARLADQSVDLNLKLM
50427899 Debaryomyces_hansenii_CBS767 IKFT-PIQSFVESSFFTKLSELKLDEFKLDSTK---------KEIKGFLT-------HPKRLNKF---NDYPTINFDYSSFDKG----------------------------PDVNEDNNISWKG----YIYNVNTIEEFK-DIDKQ---AILKRWGTEI---------------------YNEIQDGSVDLSY-ECFNKVHVLAFCDLKKYKFYYWFAFPT-LHSPWNIIG----------------------------ADGDSLKK---FIPSIKEFV-ETSKFVQFF---------------------------------QINDGNIIERVL-----------EFQESKIFV---FIDTC-LSQACTPSVQLKNYLYVL-----ARK----GFENIDLIIYR-----------NNGNSFYWKL------------QLDKDK-----------LGINEVPRILGW-ERLSNGK----LGPR--LADLGSLIDPQELAKQAVDLNLKLM
68488745 Candida_albicans_SC5314 -------QSFVESSFFTKLSELKLEKYKLDSSY---------IAIHGFQT----------HPTKLNKFNDTPVLNLDQSSFDDT-------------------------------LNDSRINIPG----ELFNVNTIEEFK-SLDKL---KLLNTWGQNV---------------------YSEVTNATSFDYK--LFNKFYILTYSDLKKYKFYYWVAYPT---LSNTWTV---------------------------ESESQETDT---TITQLVETE-LDNEYGQFF---------------------------------QYYGGKLHKSVQ------------ADKEHTFV---FIDTC-LSKDRKPSSQLKNYLYFI-----AYK----GIKEIDLVTYRNN---------NLSFTQHLKL-----------------------------DAFTDSPKISGW-ERTNQGK----LGPK--LADLGSLINPLQLAEQAVELNLKLM
68069307 Plasmodium_berghei_strain_ANKA ----------IDISFFLKLHEQKINIYKLKSDYVNLISETYVKKIKVEYKYKKINNLDIIEFYYP--YKNTSFIEINKNSFETDK---------------ICIEFRKNEEKKFQKINNYNKKYQG----LLLNFNTLEEFL-NANKT--KHVNNSMNDIKMYVVCENNEKKKKKCIYDNSFWEYKQDELDFFEK---INKYLILSYFDLKKCICYYSISNPV--------------------------------------------IK---PLGNFKEIL-PSQRLHIYI----------------------------------NTENVYLNKEI--KEINV------IDTIYLS----------QKIDDCFNSHKMFVKS---------------RVFLLLRFKND------------------------------------------------------------------------------DINDGNYYDEFMQN-----------
68124197 Leishmania_major LTFS-DLQLSIDVGFWEQLRQLKLTEWRLEEPH---------AALAGVIR---------ANVSDRVFLSPANLVHLSAGSLHPS---------------------TLTQAAAENAADVVSVQVQG----TVKSFNFAEELN-ALNLR--NALLSIAAKTLLGPAVALYA------------SAEEEADAWGNMP---FATLCMLTYIDAKTYRFFHWEAFPC-IAIESAVLV-------------DCLVLGASPALPFSAEAAQAMYR---HGTSLLRQK-PERACNPFL--------------------------------AVYANNSVEFISF--SPTAFVSATATKGDNVVV--CLFDFS--DTVGSVSLPVRNVITCL-----RLAVS--SLTTLRLYALRSG---------GTEKSVFVKLAFDALEESLVTSLRERLT-----------GASFADLARVQWKEEFPSLKASGWRKKKIECLDLGAFINPVQRADNDSRFNLELM
71748544 Trypanosoma_brucei_TREU927 LKYL-MHDFRIEISFWYELEKRKLHEWRLSEPIIR-------SPVFGVTS----------SSSSG---IYRSLVSLRAESLSAS-RVNVTRRLRDETSVSEGDPIDDHSGGTGTSLRCVHTLHDG----FIQNFNTAKQLY-QLPRR--SALWDILKKSLLLPLYTCCKNKREENVTE---YSSAEELAWEDVN---FSIMALYTYADLKSHRFLYSVAFPV-FDLGSPVFV--------QRRVKGGYTAAGSEFKGVYFPNQFAVDRVHAHLLEKLQKR-PENGPNPFIVVRSSAAD-----------------------VKGKGNNDDGCVIF--LPFSPKSMEAASNHSMPL-IAFLDYS---SEGSPGWAVRNIVSAL-----RLAQP--LITSFALYCVRNN---------DVSESVLFHCMCEPLSYTLEEVV-EGVS-----------P-----AKVVGWVDPESDGG---ASSVH--TIDLGPLMSPDKLADASAGLNLTLM
71416237 Trypanosoma_cruzi_strain_CL_Brener LKFK-EYSPHIEVSFWYELERRKLHEWRLQEPVVP-------LTLFGTVN----------SAYTA---TPANIVSARRESLGNDTDAIVAGLPQ-------NPLVGVAAATDTNAPFPIPVLLSG----ELQNFNTLEQLC-KLPRR--EAIWRVLKEKLLIPLFSGKGSKTIDVNEDRKAAEILVDKVWEGIN---FALAALFTYADLKSHRFHYMMAFPV-LDLGSPVDV--------KHRVNGGYAALATDHGVSYFSSRKAVDRIHAHLLDQLRRH-PERGPNPFIVT-----------------------------CQASGHGENEEVIF--YPFTFSTINKMKELSFLV--VMADVS--TMEDFPGWPARNVIGAL-----RLARP--SITAFALYCIRHN---------EVERSVVFECTCDPLSYTFEDVMTEGTE-----------GKQNAFARAVGWTERKSADS-----PVS--CIDLGAMMDPERLAESSARLNLSLM
71665790 Trypanosoma_cruzi_strain_CL_Brener LKFK-EYSPHIEVSFWYELERRKLHEWRLQEPVVP-------LTLFGTVN----------SAYTA---TPANIVSARRESLGNDTDAIAAGLPQ-------NPPAGVAAATDTNAPFSIPVLLSG----ELQNFNTLEQLC-KLPRR--EAIWRVLKEKLLIPLFSGKRSKTIDVNEDRKAAEILVDNAWEGIN---FALTALFTYADLKSHRFHYMMAFPV-LDLGSPVDV--------KHRVNGGYAALATDHGVSYFSSRKAVDRIHAHLLDQLRRH-PERGPNPFIVT-----------------------------CQASGHGKNEEVIF--YPFTPSTINKMKELSFLV--VMADVS--TMEDFPGWPARNVIGAL-----RLARP--SITAFALYCIRHN---------DVERSVVFECTCEPLSYTFEDVMTEGTE-----------GKQNAFARAVGWTERKSADS-----PVS--CIDLGAMMDPERLAESSARLNLGLM
124420677 Paramecium_tetraurelia MQFI-PFSPLIDIGFWSQLSKNKIEIYKLDDGE---------RSLLVKTK----------INPYP---EKTSQLYLDIYSFQDE--------------------------ITINKSGPFEVYSRI----QFQNYNTIEAYQ-EFDHL---NYVQQTFKKM------------------------IESFSKEEKP--NLFPARMSIFADLKKYLFYFKLVVPQ-FQVENIQNI-------------------IQKNLTDYLGDQMPQFQQQLSLIIQQQQK-EISNTSFVV----------------------------------LRKDNLQYVQF--EDYYK------NKSEVVF--LYFDSF---NQAQINGQFNNFIAFLLT---NNSFKD-QLNNVKIIVIKDALTINKNQF-QFKNSIYVEL-------------NLSES-----------KITELNGQYKAF---NIEGY----LQEK--RIDLKSFMDEQSLAKEAVDLNIKLM
118373250 Tetrahymena_thermophila_SB210 FEII-PFSPMADIGFWSTLAKKKLEEWKLNSDP---------QDIFVKFK----------ISNFT---SKKAFLNLDVYSFQQW---------------------------ELQLQGPVEIVIQT----QLKNYNTIEEFK-QINYH---DLFKDLTQKQ---------------------ISAIDNFLSGKDENLNAFIMKLVTFADLKKHNYSYKLCSPS-IKVDDFNLL----------------EKSSFKTAFNDEQKQKAFDE---SLKQFLKSG-KIS--PFFY-------------------------------CKEVDGGKFVFGTL--REYLS-ELETGKTNDLYG--VFFDPY--NQNTGTHAYFTNLLALVLKLAEQKGIKN-ILSNLKFILLKDSLIYNFANKYDMKNSLVVSV-------------DLTNA-----------KIDA--ESYTG-----CDPN----QIPP--SIDLKSSLDEATLATDAVDLNIKLM
123446747 Trichomonas_vaginalis_G3 MSFQ-NISSLIEPSFWYELNKVKLNDKMLDETP---------FDIISYFQ----------AGRSA---GVKAFAFINEDSFKPK----------------------------KEVHDVHFLNVLGTFPITFYLTNTKPSFK-KLDRN---GIMASLKAEM---------------------INNINSGEWINNP-SILLKSALTVFGDLKHWQYTYCFAFPN--------------------------------------PKLDNIKI---------VSK-EVTPEIEYL-------------------------------SQQTNYSNWIYVLG--PENSLLPLTEAKSDSTFV---LIDPS---TNQDLGWPAKILSLAI-----ARKF-----NTKTIKIARLSY-----------DSALFTV---------------NVE-----------DFNLNDAPFTGW---NLTPK----KTAH--FVDLSATMDPMQLFTAATSLNLRLM
67476958 Entamoeba_histolytica_HM_1IMSS VKTL-PLDLQIDVTFWHEFTKRKLEVFKLSEKA---------IPIYGSVE------------------AGSNIIRLTHASFERQ-----------------------------------ESCIEG----ELLNYNTLISFK-ESDKK---AIFTEFSERC---------------------MK-----LYEENY-SIVAKFILITYGDLKKYDFHFIGGCPV--------------------------------------PKQHKVIG---EIVNINNEE-SNDVLNKF----------------------------------KEKNCMVLNNQF--EPLKK------GDNEAYI----LDLS--PVKETPGWTVRTLI--------HHKL-------DIIHCIRPN------------NSFTLKLT----------------------------HLEEPLKGSSGWFTVKSTGK----IATQ--IHHLAESMNPEMLASQAVDLNLQLM
consensus/100% ...........p..ha..h...Klp....s... ..l..............................h....h............. ......................... ...............s.......b...s..h............... ...................h.hh.asshK.a.h.a....P.........................................................................................................................................h.s.s.......s....+phh.h. .............h...+............................................................GW ............... .........................
consensus/95% ...........p.sFa..h...Klp....sps. b.l.u.h........................h.l...uh............. ........................G .h...Ns.p.a....s+.....hh...s..h............... hpsh.p.............F.hlsasDlK.a.h.Y.hshPs...........................................h......................Fh............................................h.......................h.D.s.......ss..h+Nhl.hh .............hh.hR...............p.........................................p..GW ............... ..ph...hsP.....p...hpLpLh
consensus/90% ..a...h.o..p.sFa..l.pbKls...lsps. b.l.u.h......................s.h.l..puh............. ......................h.G .l...Nshc.ap...s+.....hhp..u..h............... hpsl.s.....ps......F.llsaADLKpapa.YbhshPs.......................................p...l.........h..........shFl.........................................h..l................p.....sh.D.s.......Puh.l+Nhl.hh .........pph.hh.hR...........p...ph...h....................................p.sGW E.p..s.....b.sb ..sls..hsP..bs.pu.sLNLpLh
consensus/85% h.a..sh.o.lp.sFap.lspbKls..bLsps. b.l.u.h......................s.h.l..puh............. ................s...h.h.G .l.s.Noh-.ap...DK.....hhpp.up.l............... hpslps.....ss...h..FhlloaADLKpapa.YWhshPs.b..s..h...............................p..sl.........h..........shFl.......................................h.h..l................p..h..sh.Dss.......Puh.lRNhlhhh ..p....h.pphphh.hR...........p..pph.h.h...................................sphsGW Ebp..u.....h.s+ .hsLs..hsP.bluppulsLNLKLM
consensus/80% hba..sh.S.lc.sFap.LspbKls..+LD-ss b.l.u.h......................s.h.lp.suh............. ................s...h.h.G .lbN.NTh-.a+.phDK.....hlpp.uppl............... hpslpss.h.bss...L.pFhlloaADLK+a+a.YWhshPu.h..s..h...............................p.psl......h.ph..........shFl.......................................h.h..L...p.p......s..pp..h..sh.Dss.....p.PuW.LRNhLhhh ..p....h.pphplhphRp..........p.spsh.hph...................................sphsGW Ecp..G.....h.s+ .hsLs..hsP.blA-pulsLNLKLM
consensus/75% hbas.Pa.S.l-.sFap.LspbKLsc.+LD-us bsl.ubh.............p.......ssphplp.suhp.s.......... ................s...h.h.G .lbN.NTlEpF+.shDK.....hLpp.uppl............... hcsIpss.hbbsP..bL.pFhlloFADLKKa+aaYWFshPu.h..s.sh...............................p.psl.p....hpph.......p..saFL.....................................sph.ls.L..pphp...b..s..pc..h..shhDss..sh.p.PuW.LRNhLhhh ..ca...h.pphpllphRp..........s.spShhhph...............s...............s..hPphsGW E+s..G.....h.s+ .hsLu..hDP.+LA-puVDLNLKLM
consensus/70% lbas.PF.S.l-.sFap.LspbKLsc.+LD-us bsl.Gbhp............p.s...s.ssplplp.suhs.s.......... ................s...h.h.G .lbN.NTlEpF+.shDKp....hLpp.uppl............... acuIpsGphhbsP..hLspFhlloFADLKKY+FaYWFuaPu.l..s.sh.........................h.....p.psl.p...shpph.ps....p..saFL...................................sssph.lu.L..pphp...b.psp.pc..l..shhDss..sh.p.PGW.LRNhLhhl ..+a...h.pplpllhaRc..........s.spShlhpl...............s.............s.ss.hPchsGW E+s.pG.....h.PR .hsLup.hDP.+LA-puVDLNLKLM
C. CCTBP domain (see also Fig. 3 main text)
FINAL ----------EEEEEE---E----EEEEE------HHHHHHHHHHHHH----E--------EEEEEEE---EEEEEE---EEEEE----HHHHHHHHHHHH--
ALIGN ----------EEEEEE--------EEEEE-------HHHHHHHHHHH--------------HHHHHH----EEEEEE----EEEEE---HHHHHHHHHHH---
HMM ---EE-----EEEEEE---E----EEEEE-------HHHHHHHHHHH-----EE--------EEEEE----EEEEEE---HHHHH----HHHHHHHHHHHH--
FREQ -----------EEEEE---------EEE-------HHHHHHHHHHHHHH------------EEEEEH-----EEEEE----EEEE----HHHHHHHHHHHH--
PSSM -----------EEEEE---E----EEEE---------HHHHHHHHHH----EE---------EEEEEE---EEEEEE---EEEEE----HHHHHHHHHHH---
52080026 Bacillus_licheniformis_ATCC_14580 VYPFLSNMSQKKADVLCGRE----TVQIRSEM-LKRLPKEELMKKLSVIG-KVDA----NDYLLHVQY-EAFRIVIFNDGRALVHGTNDIKEANSILARVIGM--
77686167 Alkaliphilus_metalliredigenes_QYMF SFIFLENKF-PEAVHICGNN----SVQVMPFT-NKKVNLDQLAIRLQEANIQVKR----TPFLLNIKT-DAHEITVFPDGRAIIKQVSNVNEAKSIYAKYIGY--
75760856 Bacillus_thuringiensis_serovar_israelensis_ATCC_35646 TYPSLTFEAQTKTEVLCGRN----TVQIRPGV-RKNFNLEEIKKRLQRSV-EIKA----TPYLLSFPV-EEYRFVLFTDGRAFIHGTNDMNVAKSLYARYIG---
16078235 Bacillus_subtilis_subsp_subtilis_str_168 DFPFLSYENQTKAAVLCGRN----TVQIRSSI-TKEADLEALAGQLRQAGLEVAA----NPYLISCRS-DDMKMVLFRDGRALIHGTNDIARAKSIYHKWIG---
56419161 Geobacillus_kaustophilus_HTA426 SYPFLSYEQRTKTAVLCGRD----SVQIRPPA-PRQYDLNELAELFRRQGLQAEA----NPYLVSVSL-GDKRLVVFRDGRALVHGTKDVQEAKAIYYRYLG---
89100758 Bacillus_sp_NRRL_B_14911 TYPYLEQDNRTRTAVLCGRD----TVQIRPPG-KRDLDLEGLAGQLGRLGYEVKG----NPYLLSAEL-GAERAVFFSDGRALIHGTKDESHAKAIYQRLLG---
27262352 Heliobacillus_mobil`is EFPFLEGKEEMQVTSLCGSN----SVQITPAR-GAKLRLDDIAERLKVLG-KVQQ----NPYLLKVLI-DQMEMILFGDGRAMIKGTQDPLVAKAFYTRYVGI--
113937611 Herpetosiphon_aurantiacus_ATCC_23779 QFDLLEQDS-APTLSLCGRN----AIQIRPQQ-PITMALAQLAAHLQQADLRVIQ----TDYLLRFAA-ETLQATVFPDGRVIISGTDDPALARGFYNRWINH--
32477346 Rhodopirellula_baltica_SH_1 EFLDAAEAGVSQAETLCGRN----AVQIPGGT--RRVDLSKIAERWNSVA-TVQA----TRFFTRLQLPDDQTLTLFRDGRAVISGVRDIPHARSIYDRYVGS--
91200473 Candidatus_Kuenenia_stuttgartiensis QYEYLRNEKYSSTTSLCGRN----AVQIAPAN-GSTIDLSTLASRLSTAG-NVSF----NKYLLRLKV-NNYELTAFPDGRTIIAGTNDVITAKGIYAKYIGM--
87308790 Blastopirellula_marina_DSM_3645 QYEWLRGDLGGQSTVLCGRN----AVQISFPD-RPAVSLEALAEKLTGVG-RVEK----NPYLLRLHV-DEYVLTIFPDGRAIIAGTTEPSVARTLYSRYVGG--
116619877 Solibacter_usitatus_Ellin6076 EFPCLVETQ-RQPATLCGRN----AVQISGVE--RPLDLAELKARLEPLG-TVRA----NEYALRFQT-DAYELTVFADGRAIVKGTGDTGIARSLYARYVG---
94969504 Acidobacteria_bacterium_Ellin345 DFSHLSGEG-RPHISLCGRN----SVQIHERQ--RPIDFAMMETRLRPHG-QVRH----NEFALRFFH-EPFEMTLFPDGRAIIKGTTDIGVARSLYARFVGS--
92089010 Lactobacillus_reuteri_100_23 SSISLEEESAPELHMLCGEN----AYYTVKE---KPIDFGRLKEFLAKKELLVNA----NRLFLHFKW-ENRPVSIFKNGKIVMYDLPTSAIAQKQFESLNILMK
28378212 Lactobacillus_plantarum_WCFS1 DWDLTTAPITNPVQVLCGTA----TYQARFTQ--KPN-LAAITDWLLDRQFSIKS----YASFISFKW-EDRPISIFKNGKVMLYNIPDLDAATATFNRLQLYLK
70725562 Staphylococcus_haemolyticus_JCSC1435 HYSLLETKHQQHIESLCGR-----TYLFRYQS-----SIFEHAHHLP--GEIVKS----TSFAKLIKD-DDYEITLFKDGRMNVYGIEDDEEAFKLYHSYLKALK
27468979 Staphylococcus_epidermidis_ATCC_12228 EYTLLESQQERTIEDLCGN-----AYLFRFPP-----KAFKHAAHFP--GNMVKS----TSFAKLIQY-QTYEFTLFKDGRMNAYGIHNDEEAHHLYNTLLKSIR
18977661 Pyrococcus_furiosus_DSM_3638 ELTFLEKQ--IKIERMCDG-----SIQVVPPE-RLEVDLEDLAKRLEEMGIEYIL----TSQFIQFED-EDYEVLIFKGGRMIIRGAEDEKTAKNIFARYLGG--
49484491 Staphylococcus_aureus_subsp_aureus_MRSA252 SYPYLNKNE-QRYATLCGRD----TVQYENTS----ITHDILVQFLKQHQLNYRS----NSYMVMFEF-KGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG---
2209267 Bacillus_firmus EYPALHASG-DLITTLCGRE----TVPIQREH---KIDLNEWSERLERVA-EVKK----TPFLLRVQLTEGEKFVTLPRWPGVNSRNRRYSRAKSLYSKYIGD--
68055196 Exiguobacterium_sibiricum_255_15 VYPYLNAPI-VQFVTLCGRD----TVQIRGEG---PRDLVRLEQELTTHGISCLQ----NPYLLMFKA-DDYRITAFADGRILLHGEANLQQAKQVYENYFTGIF
16800110 Listeria_innocua_Clip11262 EKVLSEVPFSEQTIALCGRD----TVQFHLQN---KSNYREIKQRLAEQKMLYTE----NPALLSFNY-EKYQFVIFKNGRVLLHGTENLAEAKKIYQLFFN---
16803089 Listeria_monocytogenes_EGD_e GKMVSEVPFSGQTVTLCGRD----TVQFRLPN---KSNYREIKLLLTEQKIIYNE----NPALLSFQY-EKFQFVIFKNGRVLLHGSENIAEAKKIYHLFFN---
42557747 uncultured_crenarchaeote DIDELETKQ-LIIEELCGRDRGKRTYTVTPSHISSSLNLIGIEKNAERLGYTIKTKGELGLTIMSNNS-DNLSISFMSSGAATIVGAKSEDEALSIYKSFVDDIK
116751018 Syntrophobacter_fumaroxidans_MPOB --MLLKGYRKEVVRPECRPEAQSVHCVAHLDE-DIGEVIPYLNAVLGGFQFTKDP------LCVSFKV-HGKLIAVHPR-KIAVNALRDEEEGDRILEWLKREIN
121543494 Candidatus_Desulfococcus_oleovorans_Hxd3 --MLLETYHLEIFNSECMPGAMGVHCFAHLDQ-DVSEALPYLNAVLGGDVYLSDP------PSVTFKA-QGKLITVSGR-KIAINALKDEAEAGKLVEWLKNEIN
98661583 Pelotomaculum_thermopropionicum_SI ---MYLRNYKIVGIGPCRAEGSMFRATAILSR-DIAGLLPYLNAALKWCAYEPFV------PSLTFKC-KGSPVVLHPD-RVIVGQLREVDAAEEILDAVIAFIN
83591036 Moorella_thermoacetica_ATCC_39073 ---MFLEMIDVTKVETCLADAEKIRLQAVLSQ-DIEELLPYLNTVIKNAVYNHYT------KNLTFLK-EFRLITLYPR-KLTMAKAVNMTDALQVLDWLKDLIN
77685050 Alkaliphilus_metalliredigenes_QYMF ---MYLEEIRMNFIKPCTTDAGKMQFRAKFSR-NISAIFPYINAVLKGGNYNDRG------GSLTFKR-GIAIITIFPE-KLGVSQIINESEAYEIMDIVKDLVN
77683474 Alkaliphilus_metalliredigenes_QYMF ---MYLEEIRMNFIKPCTTDAGKMQFKAKFTR-DISEVFPYINAVLQGANYNHRA------KCLTFRR-GIAIITLFPE-KLAVAKIINESEAYEIMDLVKELVN
91772349 Methanococcoides_burtonii_DSM_6242 --------MEIRSIAPCTSKPSIFHVEAQLEN--EIDIPKACEALSVEEGVTIKFLRCSEELGAIRFTSGAMMVLIYGSGKITVRHAPDDGTARQLLERVAELVE
110622212 uncultured_methanogenic_archaeon KIQDMPPDYPIVITRPCTDAPNRFIAESSFGR--KLDMQAVCETSKAIPGAKCSE-----SLGVAKFDYKDWTLILYRSGRVDLRKIKDEADARQAMGEIEALFS
57641926 Thermococcus_kodakarensis_KOD1 ----------MIIAKPCTTMKGIVISGYSWEK-PIKIDLTKTAQCLRERGHSVKK--LLPGMMLILEM-EGYEVSVYPSGKIIVKLLDDAELGRKIAETIYDCAG
18976838 Pyrococcus_furiosus_DSM_3638 ----------MLIAKPCTSMGGVLVQLYLWDK-EVKIEISKLAQELKQKGYKIKT--LIPGIMVVTEI-DGYEASIYPSGKIIIKDLRDEKKAEEIARKIYDLAG
11499827 Archaeoglobus_fulgidus_DSM_4304 --------MEIKEVLPCIADPKKLRVIGRVDG-NFPAVMPYLARLIPNASYNEKR------GWISFKK-GQRIITIHEDGFVAMTQIKDEDEAKSILGEIEQKAQ
15679358 Methanothermobacter_thermautotrophicus_str_Delta_H PQGSLVKEVTLKQVKPCIAAEGKIRVLMELDS-EIGDIIPLIANMYPPGVVNYVR----KKNILTLTI-YDRIISLYPSGKISMNKTHDVEEAFEIAGELMDRIN
20092721 Methanosarcina_acetivorans_C2A SQAKPIEIARIRQLSPCMADSSRLRVSANMTP-PLGGILKLLEPLFPRSNYSDRK------DSLIIQK-GEIIITIYGSGKVSIRMIKNENEAKEELESLKSIIN
21228363 Methanosarcina_mazei_Go1 SQSKPIEIVSIRQVLPCIADASRLRISSNITP-PPGRVLKLLEPLFQRSSYSDRK------NSLIIQK-GEIITTIYGSGKVSIRMVKNENEAKEELERLKSIIN
116754588 Methanosaeta_thermophila_PT RDARPVEVVEVKQLLPCIADTTKFRIIARMDP-PLGGALKALEPLFPRGRYSERI------GALIIQK-GTVLITLYGTGNVTMTMIRDEAHAREILEELKRTIN
21228364 Methanosarcina_mazei_Go1 SQAKPIEITEVRQLLPCIADSSKFRVIANIAP-PLGGTLKVLEPLFPRGKYSDKI------GALIIQK-GEIITTVYGTGKVTMTMIKSEAEARESLQSLKNTIN
73669228 Methanosarcina_barkeri_str_Fusaro SQAKPVEIAEIRQLLPCIADSSKFRVIANMTP-PLGGILKVFEPLFPRGRYSDKI------NALIMQK-GEVLTTVYGTGKITMTMIKNEAEAREALESLRSIIN
20092720 Methanosarcina_acetivorans_C2A SQAKPVEIAEVRQLLPCIADSSKFRVIANMAP-PLGGTLKVLEPLFPRARYSDRI------SALITQK-GEIITTIYGTGKVTMTMIKNEDEAREALENLRDIIN
118195731 Cenarchaeum_symbiosum ESTSVEANREMVVEELCGRAGGKRTFSLTPGR-VFEIDVDGITRAASARGFRVED---QGELGLSVRT-DDLSVSFMKSGSAMVVGTKDEDEARNLYNNLVGKDQ
76666624 uncultured_sulfate_reducing_bacterium NETGIRIQEHFCTTRLCGKN----AVEIAFPR-GSRIDLETLAKIWLREDRASER----DGELLLTSE-GGLQLQVHPTGKVIFVGTKDRKRAEELLQRLLIPHD
consensus/100% ................C.......................................................................p...u...h..h.....
consensus/95% ................C........h...................h.............................h..p..h.h....p...A...h..h.....
consensus/90% ................C........h.h..........h..h...h.................h.........h.ha.p.ph.h....s...A...h..h.....
consensus/85% ................C........h.h..........h..h...h.................l.h.......hsha.s.+h.h....s...Abphh..h.....
consensus/80% ................C........hbh..........h..l...h.....p.p.........l.hp....bbhsla.sG+h.h...ps...Abphh..h.....
consensus/75% ................C..s....phbhp.s.......h..l...h...s.p.p........hl.hp....bbhsla.sG+h.l...ps..pAcplhpphbs...
consensus/70% .b..h......p....Csps....phbhp.s......sl..l..bh...shp.p........hl.hp....bbhsla.sG+h.lp..ps.spAcplhpphbs...
CCTBP+classical TBP alignment
1vokA.pdb HHHHHH--------EEEEEEE-----EEEEEEE--------HHHHHHHHH------------EEEEE---------EEEEEE------------EEEEEE--EEEEEEEE-HHHHHHHHHHHHHHHHHH
157953047 Paramecium_bursaria_Chlorella_virus_NY2A SFVHEITNKELLMVLEDFKI------NMINTSS----LVTNLQNFPLSFPPKTITELIRETGQHVDFDPERY----PGVKLTITDEH----GKKASTGCVFQTGSISLIGSRSPKYIAQTFDMIAKNLD\viral \TATA-box
155371449 Acanthocystis_turfacea_Chlorella_virus_1 KQILNITGIELEVADVSTNLI-----NMSTSTVDALWRPVKFNMKHLAAAF-------ERKGVQSYFNPEQH----PAVKVLLSDS-----KKKLCTAFVFPTGSISIFGSKEPKHIAQIYRTLFEVMD/ |binding protein domain
159107688 Giardia_lamblia_ATCC_50803 KLLNEIEEFVGLARPSPLTVV-----SITCLTD----LGHGIRLDAAAAAT-------ISVFSSAMYQPEIM----PSLQVVFKI------AERNICCSVFADGQVTIVGARNIFDARDVITKLYEGLF\eukaryotic-like |
1943466 Arabidopsis_thaliana RIVQKLGFPAK---FKDFKIQ-----NIVGSCD----VKFPIRLEGLAYSH----------AAFSSYEPELF----PGLIYRM--------KVPKIVLLIFVSGKIVITGAKMRDETYKAFENIYPVLS| |
3599406 Cenarchaeum_symbiosum LHLFRNGAAAGG--CTRPVVR-----NMVATVD----AGRTVPIDRISSRI-----------PGAVYDPGSF----PGMILKG---------LGSCSFLVFASGKVVIAGARSPGELYRSSFDLLARLN| |
146084819 Leishmania_infantum_JPCM5 RIIRKALNLNFS--SLKFRVR-----SIAARFN----VCSPIRLDKLAAYQLDPAMSIGVAKLQVSYEPERF----NGCVLRLVGKSSRGDNQWSVSCSVFVTGKVQLMGARSMDELRFAFNAFVPIIA| |
71749452 Trypanosoma_brucei_TREU927 RIIRKALNLNFS--SVQFRVR-----SLMARFD----LCHPIRLDELAKHE----------GVFCSYEPDRF----SGCIVRL-SGSSRG-NQWQVCCTVFVTGKVIVLGARSREELLDAFYTVLPIIA| |
145352509 Ostreococcus_lucimarinus_CCE9901 KVIIKLGFPAQ---FKDFKIQ-----NMVGSCD----VQFPIRLEGLAWQH----------GHFAQYEPELF----PGLIYRM--------QMPKIVLLIFVSGKIVLTGGKRREDIYQAFENIYPVLT| |
39979630 Mus_musculus RVVQKLGFPVR---FFNFKIQ-----NMVGSCD----VKFPIRLEILALTH---------RQFSSSYEPELF----PGLIYKM--------VKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYPILE| |
1174643 Acetabularia_peniculus KIVQKLGFPAK---FTEFKIQ-----NIVGSCD----VKFPIRMEPLAYQH----------QQFCSYEPELF----PGLIYRM--------LQPKIVLLIFVSGKVVLTGAKERTEIYRAFEQIYPVLT| |
17555358 Caenorhabditis_elegans RIVQKLGFQAK---FTEFMVQ-----NMVGSCD----VRFPIQLEGLCITH----------SQFSTYEPELF----PGLIYRM--------VKPRVVLLIFVSGKVVITGAKTKRDIDEAFGQIYPILK| |
156392660 Nematostella_vectensis RVVQKLGFPAK---FTEFKIQ-----NMVGSCD----VKFPIRLEGLVLAH----------GQFSSYEPELF----PGLIYRM--------VKPRIVLLIFVSGKVVLTGAKVRQEIYEAFDNIYPILK| |
2897847 Homo_sapiens RVVQKLGFPAK---FLDFKIQ-----NMVGSCD----VKFPIRLEGLVLTH----------QQFSSYEPELF----PGLIYRM--------IKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILK| |
172899 Saccharomyces_cerevisiae RIIQKIGFAAK---FTDFKIQ-----NIVGSCD----VKFPIRLEGLAFSH----------GTFSSYEPELF----PGLIYRM--------VKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLS| |
19115478 Schizosaccharomyces_pombe_972h_ RIIQKLGFNAK---FTDFKIQ-----NIVGSCD----VKFPIRLEGLAYSH----------GTFSSYEPELF----PGLIYRM--------VKPKVVLLIFVSGKIVLTGAKVREEIYQAFEAIYPVLS| |
67537612 Aspergillus_nidulans_FGSC_A4 RIIQKLGFNAK---FTDFKIQ-----NIVGSCD----IKFPIRLEGLASRH----------HNFSSYEPELF----PGLIYRM--------MKPKIVLLIFVSGKIVLTGAKVREEIYQAFELIYPVLS| |
1827869 Homo_sapiens RVVQKLGFPAK---FLDFKIQ-----NMVGSCD----VKFPIRLEGLVLTH----------QQFSSYEPELF----PGLIYRM--------IKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILK/ |
124485267 Methanocorpusculum_labreanum_Z ASLKEAGVNVLD--VPRVAVT-----NIVCSYD----IGRFINLNRVVATL---------SLEAIEYEPEQF----PGLVYRI--------KDPKIVALLFSSGKIILTGGKNLDDVRKGLDFLEESLK\archaeal-like |
126179200 Methanoculleus_marisnigri_JR1 QSLRDAGVNTYD--EPQVAVT-----NIVCSYD----MGKYINLNKVVITL---------NLENIEYEPEQF----PGLVYRI--------EDPKIVALLFSSGKIILTGGKTVEDIKRGLDFLEQRLE| |
14521176 Pyrococcus_abyssi_GE5 EKLKGIGVKFKR--APLIDIQ-----NMVFSGD----IGREFNLDNVALTL-----------PNCEYEPEQF----PGVIYRV--------KDPRAVILLFSSGKIVCSGAKSEADAWEAVRKLLRELE| |
161529027 Nitrosopumilus_maritimus_SCM1 QKLRKGKIKIKN--DAVITVQ-----NIVAAIN----LGGKIHLEKAARTL-----------PRSMYEPEQF----PGLIHRM--------LDPKTVILLFASGKLVCTGAKKESDVYRSVHNLHSVLE| |
159041771 Caldivirga_maquilingensis_IC_167 KTLNQRGAQIQN--DSDIQVQ-----NIVASGN----LHAEVNIEKAALLL-----------ENSMYEPEQF----PGLIYRM--------SDPKVVILVFSSGKIVCTGAKKEADVAVAVRKLYDKLK| |
18313147 Pyrobaculum_aerophilum_str_IM2 KLLKDHGADVPF--DPEVQIQ-----NIVASGN----LHAEVDLEQAVLML-----------ENAMYEPEQF----PGLIYRM--------SSPRVVILIFGSGKIVCTGAKSEKDVATAVQKLYNQLK| |
163718252 Thermoproteus_neutrophilus_V24Sta KLLKDHGADVPF--DPEVQIQ-----NIVASGN----LFAEVDLEQAVLML-----------ENAMYEPEQF----PGLIYRM--------SSPRVVILIFGSGKIVCTGAKSEKDVATAVQKLYNQLK| |
118431620 Aeropyrum_pernix_K1 KAFADQGIPISG--KPQIQIQ-----NIVASAN----LKVYIDLEKAALEF-----------ENSLYEPEQF----PGLIYRM--------DEPRVVMLIFSSGKMVITGAKMENEVYDAVKKVARKLK| |
126466212 Staphylothermus_marinus_F1 KLLRKYGIKIVS--KPRIQIQ-----NIVASGD----INAYINLERAAYLL-----------EDSMYEPEQF----PGLIHRM--------REPRVVLLIFSSGKMVITGAKEESEVETAVRNIAKKLL| |
24638240 Sulfolobus_tokodaii KTLKRYGMNLTG--KPKIQIQ-----NIVASAN----LHVIVNLDKAAFLL-----------ENNMYEPEQF----PGLIYRM--------EDPRVVLLIFSSGKMVITGAKREEEVHKAVKKIFDKLV| |
150400624 Methanococcus_aeolicus_Nankai_3 EYLREAGLDLID--TPEVKVQ-----NMVATAE----LGMEPNLDDLSTLE------------RTEYEPEQF----PGLVYRM--------ESPKVVLLVFGSGKVVITGLKNKEDAYIALEKIKNTVK| |
14423942 Methanothermococcus_thermolithotrophicus KELKDAGMDIID--NPEVNVQ-----NMVATAD----LGIEPNLDDISTLE------------GTEYEPEQF----PGLVYRL--------SDPKVVVLIFGSGKVVITGLKKKDDAYLALDKILSTLK| |
15668684 Methanocaldococcus_jannaschii_DSM_2661 KELKDAGIDVIE--NPEIKIQ-----NMVATAD----LGIEPNLDDIALMV-----------EGTEYEPEQF----PGLVYRL--------DDPKVVVLIFGSGKVVITGLKSEEDAKRALKKILDTIK| |
16081349 Thermoplasma_acidophilum_DSM_1728 DKLKAADIEVYD--DPQIIVQ-----NIVAVYD----LESELNLTDIAMSL---------GLENVEYEPEQF----PGLVYRV--------EEPRVVLLLFGSGKVVCTGAKEESEIEQAVIKVKKELQ| |
48477578 Picrophilus_torridus_DSM_9790 DKLKKADIEVYD--NPDIIVQ-----NIVAVYD----LESNLNLTDIAMSL---------GLENVEYEPEQF----PGLVYRV--------EEPKVVLLLFGSGKVVCTGAKEENEIEQAVIKVKKDLQ| |
20093119 Methanosarcina_acetivorans_C2A KKLNSIGIKTME--NPQITVQ-----NIVASAD----LHTILNLNAIAIGL---------GLENIEYEPEQF----PGLVYRI--------DEPKVVVLIFSSGKLVVTGGKSPEDCERGVEVVRQQLD| |
11497985 Archaeoglobus_fulgidus_DSM_4304 KMLKEIGISVID--EPEVKVQ-----NIVASAD----LGVDLNLNAIAIGL---------GLENIEYEPEQF----PGLVYRL--------DNPRVVVLIFGSGKMVVTGGKSPEDARKAVERISEELR| |
10803585 Halobacterium_sp_NRC_1 GDIRELGIDVTS--NPPIEVQ-----NIVSSAS----LEQSLNLNAIAIGL---------GLEQIEYEPEQF----PGLVYRL--------DDPDVVVLLFGSGKLVITGGQNPDEAEQALAHVQDRLT| |
147920361 uncultured_methanogenic_archaeon_RC_I KKMDSVGIKVAD--NPEITVQ-----NIVASAD----LGSVLNLNAIAIGL---------GLENIEYEPEQF----PGLVYRI--------DQPKVVVLLFGSGKLVVTGGKKPKDAEEAVDRIVRELE| |
153893943 Halorubrum_lacusprofundi_ATCC_49239 DELR--GLQIPID-DPEITVQ-----NIVTSAD----LGESLNLNAIAIGL---------GLEHIEYEPEQF----PGLVYRI--------DEPDVVALLFGSGKLVITGGTSPDDAAAAVDVIVEKLD| |
76801184 Natronomonas_pharaonis_DSM_2160 DKLRDLEIQVDE--DPEIVVQ-----NIVTSAD----LGRNLNLNAIAIGL---------GLENIEYEPEQF----PGLVYRL--------DDPDVVALLFGSGKLVITGGKEPDDAREAVDKIVSRLE| |
156937779 Ignicoccus_hospitalis_KIN4/I YILKSKGIVSGKV-RPRIQIQ-----NIVASAN----LGVEVHLEKAAYLL-----------ENSMYEPEQF----PGLIYRL--------DEPRVVLLLFSSGKMVVTGAKKEEEVSKAVEKVFQNLK/ /
FINAL ----------EE--EEEE-------EEEEEE---------HHHHHHHHHHH-----------HH----E---------EEEEE--------EE--EEEEEE---EEEEE----HHHHHHHHHHHH---- \CCTBP domain
52080026 Bacillus_licheniformis_ATCC_14580 VYPFLSNMSQKK--ADVLCGR----ETVQIRSE----MLKRLPKEELMKKL-----------SVIG-KVDA-----NDYLLHV--------QYEAFRIVIFNDGRALVHGTNDIKEANSILARVIGM--\E1-like \Thiamine |
77686167 Alkaliphilus_metalliredigenes_QYMF SFIFLENKFPE---AVHICGN----NSVQVMPF----TNKKVNLDQLAIRL-----------QEANIQVKR-----TPFLLNI--------KTDAHEITVFPDGRAIIKQVSNVNEAKSIYAKYIGY--|fusion |Moco |
75760856 Bacillus_thuringiensis_serovar_israelensi TYPSLTFEAQTK--TEVLCGR----NTVQIRPG----VRKNFNLEEIKKRL-----------QRSV-EIKA-----TPYLLSF--------PVEEYRFVLFTDGRAFIHGTNDMNVAKSLYARYIG---| |biosynthesis|
16078235 Bacillus_subtilis_subsp_subtilis_str_168 DFPFLSYENQTK--AAVLCGR----NTVQIRSS----ITKEADLEALAGQL-----------RQAGLEVAA-----NPYLISC--------RSDDMKMVLFRDGRALIHGTNDIARAKSIYHKWIG---| | |
56419161 Geobacillus_kaustophilus_HTA426 SYPFLSYEQRTK--TAVLCGR----DSVQIRPP----APRQYDLNELAELF-----------RRQGLQAEA-----NPYLVSV--------SLGDKRLVVFRDGRALVHGTKDVQEAKAIYYRYLG---| | |
89100758 Bacillus_sp_NRRL_B_14911 TYPYLEQDNRTR--TAVLCGR----DTVQIRPP----GKRDLDLEGLAGQL-----------GRLGYEVKG-----NPYLLSA--------ELGAERAVFFSDGRALIHGTKDESHAKAIYQRLLG---| | |
27262352 Heliobacillus_mobilis EFPFLEGKEEMQ--VTSLCGS----NSVQITPA----RGAKLRLDDIAERL-----------KVLG-KVQQ-----NPYLLKV--------LIDQMEMILFGDGRAMIKGTQDPLVAKAFYTRYVGI--| | |
113937611 Herpetosiphon_aurantiacus_ATCC_23779 QFDLLEQDSAP---TLSLCGR----NAIQIRPQ----QPITMALAQLAAHL-----------QQADLRVIQ-----TDYLLRF--------AAETLQATVFPDGRVIISGTDDPALARGFYNRWINH--| | |
32477346 Rhodopirellula_baltica_SH_1 EFLDAAEAGVSQ--AETLCGR----NAVQIPGG-----TRRVDLSKIAERW-----------NSVA-TVQA-----TRFFTRLQ-------LPDDQTLTLFRDGRAVISGVRDIPHARSIYDRYVGS--| | |
91200473 Candidatus_Kuenenia_stuttgartiensis QYEYLRNEKYSS--TTSLCGR----NAVQIAPA----NGSTIDLSTLASRL-----------STAG-NVSF-----NKYLLRL--------KVNNYELTAFPDGRTIIAGTNDVITAKGIYAKYIGM--| | |
87308790 Blastopirellula_marina_DSM_3645 QYEWLRGDLGGQ--STVLCGR----NAVQISFP----DRPAVSLEALAEKL-----------TGVG-RVEK-----NPYLLRL--------HVDEYVLTIFPDGRAIIAGTTEPSVARTLYSRYVGG--| | |
116619877 Solibacter_usitatus_Ellin6076 EFPCLVETQRQ---PATLCGR----NAVQISGV-----ERPLDLAELKARL-----------EPLG-TVRA-----NEYALRF--------QTDAYELTVFADGRAIVKGTGDTGIARSLYARYVG---| | |
94969504 Acidobacteria_bacterium_Ellin345 DFSHLSGEGRP---HISLCGR----NSVQIHER-----QRPIDFAMMETRL-----------RPHG-QVRH-----NEFALRF--------FHEPFEMTLFPDGRAIIKGTTDIGVARSLYARFVGS--| | |
92089010 Lactobacillus_reuteri_100_23 SSISLEEESAPE--LHMLCGE----NAYYTVKE------KPIDFGRLKEFL-----------AKKELLVNA-----NRLFLHF--------KWENRPVSIFKNGKIVMYDLPTSAIAQKQFESLNILMK| | |
28378212 Lactobacillus_plantarum_WCFS1 DWDLTTAPITNP--VQVLCGT----ATYQARFT------QKPNLAAITDWL-----------LDRQFSIKS-----YASFISF--------KWEDRPISIFKNGKVMLYNIPDLDAATATFNRLQLYLK| | |
70725562 Staphylococcus_haemolyticus_JCSC1435 HYSLLETKHQQH--IESLCGR-----TYLFRYQ----------SSIFEHAH-----------HLPGEIVKS-----TSFAKLI--------KDDDYEITLFKDGRMNVYGIEDDEEAFKLYHSYLKALK| | |
27468979 Staphylococcus_epidermidis_ATCC_12228 EYTLLESQQERT--IEDLCGN-----AYLFRFP----------PKAFKHAA-----------HFPGNMVKS-----TSFAKLI--------QYQTYEFTLFKDGRMNAYGIHNDEEAHHLYNTLLKSIR| | |
18977661 Pyrococcus_furiosus_DSM_3638 ELTFLEKQIK----IERMCDG-----SIQVVPP----ERLEVDLEDLAKRL-----------EEMGIEYIL-----TSQFIQF--------EDEDYEVLIFKGGRMIIRGAEDEKTAKNIFARYLGG--| | |
49484491 Staphylococcus_aureus_subsp_aureus_MRSA25 SYPYLNKNEQR---YATLCGR----DTVQYENT-------SITHDILVQFL-----------KQHQLNYRS-----NSYMVMF--------EFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG---| | |
2209267 Bacillus_firmus EYPALHASGDL---ITTLCGR----ETVPIQRE------HKIDLNEWSERL-----------ERVA-EVKK-----TPFLLRVQ-------LTEGEKFVTLPRWPGVNSRNRRYSRAKSLYSKYIGD--| | |
68055196 Exiguobacterium_sibiricum_255_15 VYPYLNAPIVQ---FVTLCGR----DTVQIRGE------GPRDLVRLEQEL-----------TTHGISCLQ-----NPYLLMF--------KADDYRITAFADGRILLHGEANLQQAKQVYENYFTGIF| | |
16800110 Listeria_innocua_Clip11262 EKVLSEVPFSEQ--TIALCGR----DTVQFHLQ------NKSNYREIKQRL-----------AEQKMLYTE-----NPALLSF--------NYEKYQFVIFKNGRVLLHGTENLAEAKKIYQLFFN---| | |
16803089 Listeria_monocytogenes_EGD_e GKMVSEVPFSGQ--TVTLCGR----DTVQFRLP------NKSNYREIKLLL-----------TEQKIIYNE-----NPALLSF--------QYEKFQFVIFKNGRVLLHGSENIAEAKKIYHLFFN---/ | |
118195731 Cenarchaeum_symbiosum ESTSVEANREMV--VEELCGRAGGKRTFSLTPG----RVFEIDVDGITRAA-----------SARGFRVEDQ----GELGLSV--------RTDDLSVSFMKSGSAMVVGTKDEDEARNLYNNLVGKDQ>Ubl+E1-like/ |
20092720 Methanosarcina_acetivorans_C2A SQAKPVEIAEVR--QLLPCIADSSKFRVIANMA----PPLGGTLKVLEPLF-----------PRARYSDRI-----SALITQK----------GEIITTIYGTGKVTMTMIKNEDEAREALENLRDIIN\HTH+FeS \metal-sulfur|
15679358 Methanothermobacter_thermautotrophicus_st PQGSLVKEVTLK--QVKPCIAAEGKIRVLMELD----SEIGDIIPLIANMY-----------PPGVVNYVR-----KKNILTL--------TIYDRIISLYPSGKISMNKTHDVEEAFEIAGELMDRIN|fusions |cluster |
20092721 Methanosarcina_acetivorans_C2A SQAKPIEIARIR--QLSPCMADSSRLRVSANMT----PPLGGILKLLEPLF-----------PRSNYSDRK-----DSLIIQK----------GEIIITIYGSGKVSIRMIKNENEAKEELESLKSIIN| |assembly/ |
21228363 Methanosarcina_mazei_Go1 SQSKPIEIVSIR--QVLPCIADASRLRISSNIT----PPPGRVLKLLEPLF-----------QRSSYSDRK-----NSLIIQK----------GEIITTIYGSGKVSIRMVKNENEAKEELERLKSIIN| |redox sensor|
116754588 Methanosaeta_thermophila_PT RDARPVEVVEVK--QLLPCIADTTKFRIIARMD----PPLGGALKALEPLF-----------PRGRYSERI-----GALIIQK----------GTVLITLYGTGNVTMTMIRDEAHAREILEELKRTIN| | |
21228364 Methanosarcina_mazei_Go1 SQAKPIEITEVR--QLLPCIADSSKFRVIANIA----PPLGGTLKVLEPLF-----------PRGKYSDKI-----GALIIQK----------GEIITTVYGTGKVTMTMIKSEAEARESLQSLKNTIN| | |
73669228 Methanosarcina_barkeri_str_Fusaro SQAKPVEIAEIR--QLLPCIADSSKFRVIANMT----PPLGGILKVFEPLF-----------PRGRYSDKI-----NALIMQK----------GEVLTTVYGTGKITMTMIKNEAEAREALESLRSIIN/ | |
11499827 Archaeoglobus_fulgidus_DSM_4304 --------MEIK--EVLPCIADPKKLRVIGRVD----GNFPAVMPYLARLI-----------PNASYNEKR-----GWISFKK----------GQRIITIHEDGFVAMTQIKDEDEAKSILGEIEQKAQ\FeS | |
116751018 Syntrophobacter_fumaroxidans_MPOB --MLLKGYRKEV--VRPECRPEAQSVHCVAHLD----EDIGEVIPYLNAVL-----------GGFQFTKDP-----LCVSFKV----------HGKLIAVHPR-KIAVNALRDEEEGDRILEWLKREIN|fusion | |
121543494 Candidatus_Desulfococcus_oleovorans_Hxd3 --MLLETYHLEI--FNSECMPGAMGVHCFAHLD----QDVSEALPYLNAVL-----------GGDVYLSDP-----PSVTFKA----------QGKLITVSGR-KIAINALKDEAEAGKLVEWLKNEIN| | |
83591036 Moorella_thermoacetica_ATCC_39073 ---MFLEMIDVT--KVETCLADAEKIRLQAVLS----QDIEELLPYLNTVI-----------KNAVYNHYT-----KNLTFLK----------EFRLITLYPR-KLTMAKAVNMTDALQVLDWLKDLIN| | |
98661583 Pelotomaculum_thermopropionicum_SI ---MYLRNYKIV--GIGPCRAEGSMFRATAILS----RDIAGLLPYLNAAL-----------KWCAYEPFV-----PSLTFKC----------KGSPVVLHPD-RVIVGQLREVDAAEEILDAVIAFIN| | |
77685050 Alkaliphilus_metalliredigenes_QYMF ---MYLEEIRMN--FIKPCTTDAGKMQFRAKFS----RNISAIFPYINAVL-----------KGGNYNDRG-----GSLTFKR----------GIAIITIFPE-KLGVSQIINESEAYEIMDIVKDLVN| | |
77683474 Alkaliphilus_metalliredigenes_QYMF ---MYLEEIRMN--FIKPCTTDAGKMQFKAKFT----RDISEVFPYINAVL-----------QGANYNHRA-----KCLTFRR----------GIAIITLFPE-KLAVAKIINESEAYEIMDLVKELVN/ | |
91772349 Methanococcoides_burtonii_DSM_6242 --------MEIR--SIAPCTSKPSIFHVEAQLE-----NEIDIPKACEALS-----------VEEGVTIKFLRCSEELGAIRF--------TSGAMMVLIYGSGKITVRHAPDDGTARQLLERVAELVE>solo / |
15679008 Methanothermobacter_thermautotrophicus_st DLTGRKTPDEAM--IYRPCRDAESRIMFEVKLP----YSIDIARTCRELMD-----------RGPRCSEKM-----GVIMLEA----------GDGNVTIFRNGKIVARRVRDQEEGRGCHP-------\PP-loop \ThiI-like? |
76666624 uncultured_sulfate_reducing_bacterium NETGIRIQEHFC--TTRLCGK----NAVEIAFP----RGSRIDLETLAKIW-----------LREDRASER-----DGELLLT--------SEGGLQLQVHPTGKVIFVGTKDRKRAEELLQRLLIPHD/fusion / |
57641926 Thermococcus_kodakarensis_KOD1 ----------MI--IAKPCTTMKGIVISGYSWE----KPIKIDLTKTAQCL-----------RERGHSVKKLL---PGMMLIL--------EMEGYEVSVYPSGKIIVKLLDDAELGRKIAETIYDCAG\solo |
18976838 Pyrococcus_furiosus_DSM_3638 ----------ML--IAKPCTSMGGVLVQLYLWD----KEVKIEISKLAQEL-----------KQKGYKIKTLI---PGIMVVT--------EIDGYEASIYPSGKIIIKDLRDEKKAEEIARKIYDLAG/versions /
D. TRS4-C domain
FINAL -----HHHHHHHHHHHHH-------------------EEEEEHHHHHHHHHHHHHH---------------------EEEEEEE------------------------------------EEEEE-HHHHHHHHHHHH--------------
ALIGN ------HHHHHHHHHHHH--H-H-------------HHHHHH----HEEEEEHHH----------------------EEEEEE-------------------------------------EEEEE--H-HHHHHHHHH--------------
HMM -----HHHHHHHHHHHHH--H----------------EEEEE-HH-HHHEEEHHHH--EEE---------------EEEEEEEE-----------------------------------EEEEEE-HHHHHHHHHHHH--------------
FREQ -----HHHHHHHHHHHH-------------------HHHHHHHHH-HHHHHHHHHH---------------------EEEEEE--------------------------------------HEEE-HHHHHHHHHHHH--------------
PSSM -----HHHHHHHHHHHHH--H----------------EEEEE----HHHHHHHH------------------------EEEE---------------------------------------EEE--HHHHHHHHHHHH--------------
89286905 Tetrahymena_thermophila_SB210 -----YAKLFNHLQQEAR--KIGI-----------SYEDLEFDMEDIYIVAREVYDWKEVVTD----------KKVCGGLVVRW---------------------------NPELPFKPENFVLLNYQDAKKHCTFTKFT----EVQEAYPK--
10177437 Arabidopsis_thaliana -------DLDHYRLLHQR--LIEHEETVY-----GTSAEVEVDVEEVMYIVKELWHGRSARDETAKDVGRGMWRAMNELMLVRW---------------------------DAKKPATVSNLVLLKFKEADEHETKTLEEVK--ESETEF----
52076969 Oryza_sativa_japonica_cultivar_group -------DLDHYRILHHR--LLEHEELIY-----GSAEQVLVDAEEVMYIVKELWRGRSARDQNLKDTGRKMWRSVNELMLVRW---------------------------DKSKPAGVSNLILLKFNEADAHESTTLDQIK--EEEPEF----
2414593 Schizosaccharomyces_pombe ---LYEEAVKRLHA-EAR--KA------------GVNLDKTFNASEMSYIIEEVYVGRSALPP---------HES-QKVTVVRW---------------------------NPQLPFDHTNLVAMTRNEARYHEDNVLAKNV--DPSTVY----
50556458 Yarrowia_lipolytica_CLIB122 --KAYDQIQQTLVGQLAR--ESKRRTGEN-----GIRIAAPFDSADVGYLVEEVYKNKSVISG---------EC--SRLSLSRW---------------------------RKEGPINLQNVVVMTKDEQKKHEELVLRDENPMTVEEVYPEW-
6321790 Saccharomyces_cerevisiae -LKFYDSILETFQKQMAR--LNE-----------NKERSSLLGLEEVGYIVEEMFRGKSPISG---------YS--TKLALTKW---------------------------EANKEISLTNVVLMTKEEQEIHEKRILLDGE--K---------
51012833 Saccharomyces_cerevisiae -IKVYDGIYQSLAGQMSR--VGIP----------SQRI--PLALKDVSYLVEEVFKGKSPISG---------IS--TRLTLTKW---------------------------DPSKPISLQNVVVLTKNEQKVHEDRVLKGKE--SLQDVY----
44985800 Ashbya_gossypii_ATCC_10895 -IKLYDGIYHSLAGQMSR--IGMP----------DQRV--PVSVADVAYLVEEVYRGKSPVSG---------YS--TRLTLSKW---------------------------DPSQPVSLQNVVLLTKEEQTAHEARILNGDE--RLEDVY----
50309567 Kluyveromyces_lactis_NRRL_Y_1140 -IKLYDGIYQSLAGQMTR--IGQK----------DQRI--PIALSDIGYIVEEVWRGKSPISN---------YS--TRLTLSKW---------------------------DPTKPVSIQNVILLTKDEQREHEARILNGTE--TFSDVYSE--
49527664 Candida_glabrata_CBS_138 -IKVYDGIYQSLAGQMTR--IGMP----------DQRV--PIALKEVGYIVEEVFRGKSPVSG---------FS--TRLTLSKW---------------------------DPKKPVSLQNVVVLTKEEQKEHEQRILNG--------------
50406518 Debaryomyces_hansenii_CBS767 -YKVYDGILQSLAGQQSR--IGKL----------DQRV--PIALNDVNYILEEVFHGKSPISN---------YS--TRLTLSRW---------------------------DPRKELSYQNVVIMTKEEQKLHEDRVLKGGE--LLTEVYTK--
68472735 Candida_albicans_SC5314 -YKIYDDLLQSLAGQQTR--IGKT----------DQRV--QIAMHEVNYILEEVFRGKSPISN---------YS--TRLTLSRW---------------------------DPSKEISLQNVVVMTKDEQRNHEKRVLNGGE--KIEDVY----
68472992 Candida_albicans_SC5314 -YKIYDDLLQSLAGQQTR--IGKT----------DQRV--QIAMHEVNYILEEVFRGKSPISN---------YS--TRLTLSRW---------------------------DPSKEISFQNVVVMTKDEQRNHEKRVLNGGE--KIEDVY----
90301656 Coccidioides_immitis_RS --KLYDSVLGALQGTEER--LAKHDNKDPV----GLRI--PITKDDVGYLLEEVWRGKSVVSG---------LT--TRLALVRWERPGEGFGADPKWDQHG----------QKGVKMRLRDLVCMTKEEAQRHEREVLKGGK--KPAE------
67537088 Aspergillus_nidulans_FGSC_A4 --KLYDTVHAQLLVTLER--LARAESESGTQ-PIGLRL--PMSRDDVIYLVDEIWRGKSVVTG---------LP--SRLALTLWNRPSNGFKPDPQWEKEG----------QILIPFKPEDLVLMTKEEATRHEKEVLMGGK--KVE-------
70998090 Aspergillus_fumigatus_Af293 --KLYDSIIASLQGLHER--LARAEAGQDLI---GLRI--PISKDDVGYLVEEIWRGRSAISN---------LT--NRLILVPWQRPARGFLPDPEWEKEG----------QKFIPIDLKNLVCMTKEEGARHEREVLRGGK--DVTEVY----
83766276 Aspergillus_oryzae --KIYDSVQTATQGFMER--LARVEVGQHVI---GLRL--PITKGDVVFLVDDIWRGKSAITG---------LP--GRLILVPWERPARGFVPDPEWEKQG----------QKFLPFELKDLVCMTKEESARHEKEVLLGGK--KPE-------
39970779 Magnaporthe_grisea_70_15 --KLYDQALASLQGTEAK--VVRSFNGGNADIVVGLRT--PLSPGDIAFMIEEVFRGRSAITG---------IA--TRLVLVRWRRPATDPLMVIEGAPDDDGPQKSAPAPQKSTRLRLSDLVCMTKDEAMVHLREVLLAGK--QPEEMY----
46135795 Gibberella_zeae_PH_1 --KMYEGMLATIQSSEEK--LARMTYEGDTV---GLKV--PITTGDVAFLSEELYRGRSAISG---------IP--TKLVLIRWEKPEGPSMTTLGEGKDT----------QKCSTVKLRDLVLMTKEEATRHEKGIFKEGK--SLDEVYDAET
38567303 Neurospora_crassa --KMYDGIQAFVQASEEK--IIRAVTGGPRELCIGLKV--PIQPCEVSFLVEDIYKAKSAVTG---------LP--TKLVLIRWQKPTRDILIRIGEGADE----------QKSSDLKLSELVCMTKDEATRHQREVLLGEK--TLEE------
88182131 Chaetomium_globosum_CBS_14851 --KMYEAILAYVQASEEK--VVRMFEGGRVDVCIGLKV--PITPGDVAFLVEEAFRGRSAVTG---------IP--TKLMLIRWKKPQKTTLVQIGEGKDE----------QKSADLKLRDLVCLTKEEAVRHQKEVLLGDK--SLE-------
71023313 Ustilago_maydis_521 --KLYEKLFHDLSVSEARHPLAGSQVDSQDAQNTGPRHHIPFSINDIAYLFEEVFRGRSIVPP---------FESLSGAQLHRW---------------------------DSTLPLSFQNVALFSRSQAKVHESEVLKKGR--SPVEVW----
57230803 Cryptococcus_neoformans_var_neoformans_JEC21 ---VYQSLERGLSDRETK--VKGE----------KLQGKLPISLEDIGFVFEELYHGRSSLPP---------FEVLQKANVIRW---------------------------QKNQDLSADNLVVMGNKDAEKHTKECLIGDR--DVREVW----
66827717 Dictyostelium_discoideum_AX4 -----------------------------------------MGPLDIRYIIDEIYEKKSGISG----------QQSSVLIVIRW---------------------------RPEKPCAPNNLIYLSQAEAEIHEKVT-------NIDQHYPK--
consensus/100% .........................................h...ch..h...ha..p......................h..W................................h...p.hhh...p...H.....................
consensus/95% ....ap.h.................................h...-l.al.cpla..pSs.s................h.h.bW...........................p....h...shlhhsbp-...H.p...................
consensus/90% ....Yp.h...l..p..p..................p....h...-l.al.-pla.spSslss..............cL.h.+W...........................p....hp..shlhhsbpE...Hbp.........p.........
consensus/85% ....Yc.lb..l..pb.p................s.p....h...-l.al.-pla.upSslos.............pcL.hs+W...........................p.p..hp..shlhhocpE...Hbpb........p.p.......
consensus/80% ....Yc.lb.pl..pb.c................s.ph...hp.p-l.alh-pla.upSslos..........p..scL.hsRW...........................p.p..hs.bNhlhhT+cE...Hbpb........p.pp.a....
consensus/75% ....Yc.lhppL..pb.c..h.............s.ph...hp.pDl.Yll-pla.upSslos.........hp..scL.lsRW...........................p.p..hs.bNhlhhT+cEsp.Hbpb........phpp.a....
consensus/70% ....YcslhppL..pb.c..h.............s.cl...hp.pDl.YllEclapu+SslSs.........hp..scL.lsRW...........................p.pb.hu.bNhllhTK-Eup.Hbcbs.......plpcsY....
E. wHTH domain (N-terminal to PaaA, MccB, GodD, and Rv3196-like families)
FINAL ----------EEEEE----EEEE--EE---EEEE-E----HH----HHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHH---EE------
ALIGN -----------EEEE----EEEE--EE----EEE-E-----H----HHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHH-----------
HMM -----EE---EEEEEE---EEEE--EE---EEEE-E----HH----HHHHHHHH-----HHHHHHHHHHH-----HHHHHHHHHHHH---EE-------
FREQ -----------EEEE----EEEE--E-----EEE-E----HH----HHHHHHHH-----HHHHHHHHHH------HHHHHHHHHHHHH--HHH------
PSSM ---------EEEEEEE---EEEE--EEE--EEEE-E-----H----HHHHHHH------HHHHHHHHHHH-----HHHHHHHHHHHHH-----------
113475987 Trichodesmium_erythraeum_IMS101 -MSNPQIKPHFHIEIIEPKHVYL--LGENSTDAL----TGEF----YCQLIPLLDGQHSFEEICETLAEIA---YPEDVEYVLNRLKTKGYLTEATPEL\GodD
119492367 Lyngbya_sp_PCC_8106 STPLLQIQPHFHVEVIEPKQVYL--LGEQANHAL----TGQL----YCQILPLLNGQYTLEQIVEKLDGEV---PPEYIDYVLERLAEKGYLTEAAPEL|
114567303 Syntrophomonas_wolfei_subsp_wolfei_str_Goettingen MHEKPQFKAHFNIHIVGDEKAVF--LLSELDYYV---LQGRI----YCLLAPLLDGKHSVDQIIDHLAGQA---SIAEIYYALALLEKKAYITEAGGDF|
78042201 Streptomyces_sp_TP_A0584 ------------------------------------MLRGQL----VESLSPLLMAGRTEDDLVTALAGMF---PAQRILSALRQLEKAGYVRRAEAAT|
90290044 Burkholderia_pseudomallei_1710a FSRVLRFKPHLLVRDAGSGALYV--VDEFRRSVL----PGDV----FPAIAACMRDRLTIAQTFAALAARF---SQWEVLAALDQLVRRGYVRADAPGE|
115375227 Stigmatella_aurantiaca_DW4/3_1 LRRVLQFKPHLRTEWLDTDRFFL--IGEREQFML----AGKV----QVLVASMLDGRRSVSDIVSALEGRA---SAPEVLYALSMMEKRGYAVDAAPGI|
62910840 Prochloron_didemni QPTALQIKPHFHVEIIEPKQVYL--LGEQGNHAL----TGQL----YCQILPFLNGEYTREQIVEKLDGQV---PEEYIDFVLSRLVEKGYLTEVAPEL|
99907729 Burkholderia_pseudomallei_1655 FSRVLRFKPHLLVRDAGSGALYV--VDEFRRSVL----PGDV----FPAIAACMRDRLTIAQTFAALAARF---SQWEVLAALEQLVRRGYVRADAPGE|
83718548 Burkholderia_thailandensis_E264 FSRVLRFKPHLLVRDTGSGALYV--VDEFRRSVL----PGDV----FPALAACMRDRLTIAQTFAALAARF---SQWEVLAALDHLVRRGYVRADAPGE|
107027472 Burkholderia_cenocepacia_AU_1054 LSRVLRFKPHLLVLDAGPETLFV--VDEFRRAML----SGAI----FVRIAACLRARMTIAEIVTSLAGTF---GEWDVLARLDHLVRRGYVRADPPHA|
114765687 Roseovarius_sp_HTCC2601 IQR-PVIKSKYVVVPVSGEGIYL--LSENEKHVL----EGET----MMQLVPLLDGQRGWPEIHATLAPAL---GPDAVGQGIEVLLANAHVEEAQPDD|
118713109 Burkholderia_cenocepacia_MC0_3 LSRVLRFKPHLLVLDAGPETLFV--VDEFKRAML----SGAI----FVRIAACLRARMTIAEIVTSLAGTF---GEWDVLARLDHLVRRGYVRADPPHG|
98660079 Pelotomaculum_thermopropionicum_SI -MNIPAFKSHFQVEVFPGEGVLL--LSEAGAGAL-YGRAYEL----VAPLV---DGRRSAGEIVDALAGQL---DAATVYYVLALLESKGYLTEAAPEI|
115359737 Burkholderia_cepacia_AMMD LSRVLRFKPHLLVLDAGPETLFV--VDEFKRTML----SGAI----FVRIAACLRARMTTAEIVTTLAGTF---GEWDVLARLDHLVRRGYVRADPPHD|
27379649 Bradyrhizobium_japonicum_USDA_110 RKDLLRFAPNFTAYLLPPDAVCL--YSEDRKFFL----HGEL---YCALATAIGEHGNARPAIIRQLSKRF---PADKIEEAIKRLLDRRYVVARVSPA|
126661106 Cyanothece_sp_CCY0110 --------------------------------------------------MPLLDGHHTTNEIVDLLPEI----SATEIFYALMLMEKKGYIIENQKPL|
78186744 Pelodictyon_luteolum_DSM_273 MLQIPVFKAYLEPIAVPGEGLLL--FSEDGSRAF----HGSL----FEQLARLIDGSRSSDEIVAALAAAH---DAATVYYALMMLEKKGHITEHIPGI/
78214014 Synechococcus_sp_CC9605 --MQLQLKRSISIRQDRNGGLTF--GMAPPRHFI-LESPPPF----LALLLEILNKPQSLEEVIEKLTQENQNWKPSEISQIWQELIDLNILEEPRKAG\MccB
116073134 Synechococcus_sp_RS9916 -MDKIQIKRSISIQLSPSGKIQF--WMAPPRAFT-LEEPPEF----LADLCRILNSPVSLEDLCSRLKNTKSDASVENIIQCIKELYDYGVIEEVESSH|
67551179 Escherichia_coli --MDYILGRYVKIARYGSGGLV---GGGG-KEQY-VEDLALW--ENIIKTAYCFITPSSYTAALETVN------IPEKDFSNCFRFLKENFFIIPSEYN|
32455339 Helicobacter_pylori FVQWYQTSFSACVGQTDTENII---GLGT-YQYC-VDHNEFE--KSLK-LLVFLRMKKRMAEIKSFMETSK---IEHNIFDKLVANKLITSFILNPNDE|
113460167 Haemophilus_somnus_129PT --MKYITSKHVFFDYLNENEFVI--GIGS-NQEI-TNNKDYF--NNCLNLCYFCINPKSISEILSFIKDNN---IDILYFDKMKKMKFITKEIIDFNDR|
42518106 Lactobacillus_johnsonii_NCC_533 --MFYKTSYLATGGCSNHQGIL---GVGT-KQYF-VSEADYL--KSLK-ILDFLLNKKTYDEVIKFCEKNN-INKSIFDTLVEHNLIVKENLYVEKKDD|
55823830 Streptococcus_thermophilus_CNRZ1066 --MKYKTS-LTATTLKSNENLI---GIGS-KQYT-VNDDEFN--LSLK-ILEFLLTEKDEDEILNWLDSNN-IDKSVFKKLVANKLITTSKAVFQKEDT|
49475959 Bartonella_henselae_str_Houston_1 MEQQYILGKYTRVVVHKKNAIF---GAGS-KQFI-INDRKHW--ENLVLLAAQWIEKKTKEETYNSLSSI----MSRENFNRAFNFLFSNHFLVLAETS/
47569967 Bacillus_cereus_G9241 MNFLPKYKVIHPCYEFDSGTIRL--GDSFGTAVE-IDDTNKS----IRTLIKLLDGTKTINEIYEEIIKSYPKIQLAEVIEAIEELNDLGFLINNSLEI\paaA
29375896 Enterococcus_faecalis_V583 KYKYPRIKPIYPLYQLNKERFRV--GAQLGITIE-FDDDEGQ----FWTLSNLLDGVRSFDEVVTEMKRKYPELTVKDIEEGIDFLNDEGLIEETFPGR|
89202940 Bacillus_cereus_subsp_cytotoxis_NVH_391_98 NTSKPRIKLIHQVLYLN-GRVRI--GGGSQHAIE-IEDPNQY----FKPLIKLLNGSYTIEEISHQLSETF---SYEEIIDSINLLAENGYIEDMNISP|
7934570 Pantoea_agglomerans TNVKPLIKESHHIILADDGDICI--GEIPGVSQV-INDPPSW----VRPALAKMDGKRTVPRIFKELVSEGVQIESEHLEGLVAGLAERKLLQDNSFFS|
37526106 Photorhabdus_luminescens_subsp_laumondii_TTO1 SLNNPRLQPTVVAVPISNNAIAIHSGTRQGEASKIIPDPDGW----KIVALNHMQGKLNSSGLLKVLKQNGHDVEESALTQLIEELQSHNLVQDEKYFD|
84495334 Janibacter_sp_HTCC2649 DPLRPRLKDVVWGRSTDAELIVV---YDQREPLV-VSDPDGT---IERFLELLQEGSRSVPELSHAMSSTGEPVTVADVWSVLEVLDAHGLVVDGSRLG|
116669519 Arthrobacter_sp_FB24 AATTYSLKQSLPVVTTD-TSVHI--GLAPPNAIE-IEDAPDG----LAELLGFASQPRTLDELGNEAQLL----LGESSGQIVEELIDAEILVPYRIDL|
106894495 Clostridium_sp_OhILAs -MNKPKLRSSVSVVKLDDRLIEF--FLTNTRQQVRVKVNSDK----VLELILGLDGTKSIDEIIENYKMDEE--TSKYFISFINFLESKGIVKDNTDVL|
47568948 Bacillus_cereus_G9241 --MRPKFKEIMKPVVVHQNVIRI--GLETDSYE--IDDSDGV----INEIIELLDGKRDILEISEVSSI-----PVDMIEECIHALNEIGCIEDESVDP|
75759314 Bacillus_thuringiensis_serovar_israelensis_ATCC_35646 --MKPKFKETIPYFFLN-KEIQI--GEEEGLAGI-IPDPTGS----ISFLINKLDGQRNIPNIVQEVQKEFPNISSNEIIEAIKVLGNEGYLEDNSIVP|
89076584 Photobacterium_sp_SKA34 MIVKPLLKQSHHVIVSDDGDICI--GEIPNVSQV-IESPPNW----VKDVLGKLDGKRTVPRIIKELV------HENVGASEDDIYNFIGMFVVA----|
116627432 Streptococcus_thermophilus_LMD_9 KFHCPRIKEIYPIYKLHDNLFRV--GSQIGITTE-ISDEDDK----MWSLVNILDG-RTINDVVDIMLTKYPDLTEQDIIGAIELLDKEGVIEEGTTIN|
89255366 Rhizobium_etli HYFKPLLKRSHQVFVADDGSIWI--GKESQKSRKIIQSPPPW----VAGLVSKLDGEYTLPRILSELKSERYDVTKCDVHDFVSALASCGLIEES----/
29829609 Streptomyces_avermitilis_MA_4680 --MHPMVKPALRRGWRDLNTVQF--GMAPAHAMV-LGPMDTA----TGSFLALLDGTRGLPLLREEGRRMGL--PDGHVDGLVERLAASGLLDDATGGG\Rv3196-like
108798383 Mycobacterium_sp_MCS -MSTYRLREALPVLLRPDGAVQI--GWDPRRAML-VRPPAGLTASALADLLRTLQSGMTTADLYAAAREHGTA-DPAELTEIVSALAGAGVLIVDSPRH|
126434067 Mycobacterium_sp_JLS -MSAYRLRETLPVLLRPDGAVQI--GWDPRRAML-VRPPAGLTASALADLLRTLQSGMTTADLYAAARERGTA-DPAELTEIVSALAGAGVLTVDPARH|
145596247 Salinispora_tropica_CNB_440 ALPRPTLLPGLTRLWRDRHTLQL--GVDPSRAVL-LELANPR----TARLLDLLDGAHSERHVLEQANRIKV--GPDEARTLIEALRTAGLVVPAHTLL|
21223562 Streptomyces_coelicolor_A32 PGMHPMVKPALRRGWRDLNTVQF--GMTPAHALT-LAPVDTA----TGSFLELLNGTRGPALLREAGHRMDL--PDGHVDRVVERLALAGLLDDSRGGG|
119882897 Salinispora_arenicola_CNS205 ALPRPTLLPGLARLWRDRHTLQL--GVDPSRAVL-LELANPR----AARLLDLLDGAHSERHVLEQASRIDV--GRDEARTLLDALRVAGLVMPAHTLL|
15610332 Mycobacterium_tuberculosis_H37Rv ASALYSLNPAMPVLLRPDGAVQV--GWDPRRAVL-VRPPRGLTATGLAALLRSMRSPIPITELQRQAAERGLV-DGDAMANLVAQLVGAGVATPLANPG|
81252102 Mycobacterium_tuberculosis_C ----------------------------------------------MAALLRSMRSPIPITELQRQAAERGLV-DGDAMANLVAQLVGAGVATPLANPG|
145225235 Mycobacterium_gilvum_PYR_GCK TMTRYALSPATPVLSRPDGTVQV--GWDPRKAVV-VRPPAGLPGSVLAELLRALQGVATAPQLQRLAAGHGV--DAPVVDGLVAHLVTRGVVTEAPRTP|
120402810 Mycobacterium_vanbaalenii_PYR_1 -MTRYAVSSATPVLSRPDGTVQV--GWDPRRAVV-VHPPAGLPAAVLAELLRALQGAATAPELQKVAAGHGV--AATVVAGLLSHLVDAGVVVPTPPGV|
117928975 Acidothermus_cellulolyticus_11B --MRPRLKPAVRVLWRDAATVQF--GVDARSAVA-VTGVDPC----TAALFDALDGSRTDAELRVLGRQLGL--DASSVDRLLDWLRSGRLLDDAARRP|
118617990 Mycobacterium_ulcerans_Agy99 MPALYSLDPAMPVLLRPDGAVQV--GWDPQRAVL-IRPPEGLTTTAVAELLRSMRSPIPITELQRHATGRGW--VPGDVANLVSQLVGAGVATRRHRHR|
54026503 Nocardia_farcinica_IFM_10152 RPLGPMLHPRVTVLVRPSGVVQL--GWDPERALL-LDPPGLDTAA-VLGFLRLLDGLRTRPEILWEAERGGI--AAERAGALLDEIDAAGLLRAPRERP|
86742467 Frankia_sp_CcI3 --MRPILKPGLRRLWHNSSTLQL--GIDTARAVI-LADLAPS----DAALLDALDGSRTLEQLRLD--------GTPAGRVLLDLLAEAGLLDDATAPP|
111225377 Frankia_alni_ACN14a --MRPILKPGLRRLWHNSSTLQL--GIDPARAVL-VTDLGPP----HAALLEALDGRRTLQQLRHD--------GGAAARDLLDLLGRAGLLDDAAPPP|
118472615 Mycobacterium_smegmatis_str_MC2_155 MTARFTLTPDRPVLLRPDGAVQI--GWDPRTAVR-VRPPDGMTPTQLTDLLHALQTGRSIEQLRSATEQFG---DPALVGDVLAALDSAGVLVRRSASP|
41409392 Mycobacterium_avium_subsp_paratuberculosis_K_10 PAATYALDPAMPVLLRPDGAVQV--GWDPRRAVL-VRPPRGLAAAELATLLRSMCSPTPLSELQRRALEHGLT-DADGLRNLVTQLVGAGVASECGRSG|
118463035 Mycobacterium_avium_104 PATTYALDPAMPVLLRPDGAVQV--GWDPRRAVL-VRPPRGLAAAELARLLRSMCSPTPLSELQRRALEHGLT-DADGLRNLVTQLVGAGVASECGRSG|
68231872 Frankia_sp_EAN1pec --MRPVLKPGLRRLWRDSTTLQI--GVDPLRAVI-ITDLSPA----DVSALDALDQPGPHLDPGGQA-------DDPATQVMIEMLAQAGLLDDSADTE|
111023348 Rhodococcus_sp_RHA1 PHVGVTLDPRIAVLVRPDGRVQF--GWDPERALV-LAPPPGVRTEQLLAVVRLLDGKNSRPHILWTAVGYGL--APTDVSKLLGDLDRAGLIDVAGTSP|
62425939 Brevibacterium_linens_BL2 ----------MPITWRSSACVQF--GVDDPVLID---GLLPA----DVALIEELRMGVGSAQYYSRAQDLGA--DLGRASSLITLLDEAGVMVPDDSDA|
21323546 Corynebacterium_glutamicum_ATCC_13032 QMTHIALANSAQVLIRPDSAIQF--GIDATRAGV-LNIDPSLSSR-VVPVLRNLRTARPIVDVIADLTTAGL--APTAASSLLEDLLEFGVVRESAAAQ|
38233333 Corynebacterium_diphtheriae_NCTC_13129 QGGLISLSPHAQVLLRPEG-IQF--GLDSANAGI-FAAPESLIVA-IVQVLRGFWQPIAKTTAIEQLTEAGL--QPVAARGLIDDLLHHRVLSIVERNL|
145294943 Corynebacterium_glutamicum_R QMTHIALANSAQVLIRPDSAIQF--GIDATRAGV-LNIDPSLSSR-VVPVLRNLRTARPIVHVIDDLTTAGL--APTAASSLLEDLLEFGVVRESAAAQ|
19552006 Corynebacterium_glutamicum_ATCC_13032 -MTHIALANSAQVLIRPDSAIQF--GIDATRAGV-LNIDPSLSSR-VVPVLRNLRTARPIVDVIADLTTAGL--APTAASSLLEDLLEFGVVRESAAAQ|
25027352 Corynebacterium_efficiens_YS_314 SMTHIMLSPSAQILIRPGPAIQF--GVDATRAGILELESPELASR-IVPVLLALRAGQGVEGVVDKLTTAGL--GRGAATSLLEDLLAYRVLRECAPGE/
consensus/100% ..........................................................s.......................h..h.............
consensus/95% .................................................h....p...s.......................l..h.....h.......
consensus/90% ......h.............h.h..........................hh..hp...s..ph...............h...l..L....hh.......
consensus/85% ......h.............l.h..........................lh..hps..s..pl...h.......s...h..hl..L...shl.......
consensus/80% ......hp..h.....s...lbh....p..p........s.........lh..hps..s..pl...h.......s...h..hlp.L...Ghl..s....
consensus/75% ......hp..h.hb..ss..lbh....p..ps......ss......h..lh..hpu.bs.spl.p.h.......s...h..hlp.L...Ghlp.s....
consensus/70% ......hps.h.hb..ss.slbl..s.-..pshl....sssh....hs.ll..Lcu.bs.spl.p.h.......ss..l..hlp.L.p.Ghlp.ss...
F. McbD domain
FINAL ----------------------------HHHHHHHHHHHHHHHHHHHHHH---------------EEEEE----------EE---------E------HHHHHHHHHHHHHHH------HHH--------------EEE------------------------------HHHHH---------------------------------------EEEEEEEE------EEEHHHHHHH--------------EEEEEE----------HHHHHHHHHHHHHHHHH-----HHHHHHHH----------------------HHHHHHHHHHHHH-------EEEEE------------EEEEEEEE--------E------------EEEEE-----HHHHHHHHHHHHHHHHHHHHHH-------------------------------E--E------HHHHH--------------------------------------HHHH-HHHHHHHHHH-----EEEEE-----------EEEEEEE--------------------HHHHHHHH------------HHH------
ALIGN ----------------------------------H-----------HEE---------------EEEEEE----------E---------EE-----HHHHHHHHHHHHHHHH------HHH-------------------------------------------------------------------------------------------EEEEE----------EEE----E----------------EEEEE--------HHHHHHHHHHHHHHHHHHH-----HHHHHHH------------------------HHHHHHHHHHHH------EEEEEE-------------EEEEEEE---------------------EEEE-----H-HHHHHHHHHHHHHHH--HH--------------------------------HH--HHHHHHHHHHHHHH------------------------------------HHHH-HHHHHHHHHH---E-EEEEE-----------EEEEEEE-------------------------------------------------
HMM -----------------------------HHHHHHHHHHHHHHHHHHHHHH-EE-----------EEEEE-------------------------E--HHHHHHHHHHHHHHH------HHH------------EEEEEEEE---------------------------HHHH----HHHHH-----------H---------------E---EEEEHHEHH-----HEEEHHHHHH--------------EEEEEE----------HHHHHHHHHHHHHHHHH-----HHHHHHHH----------------------HHHHHHHHHHHHH------HHHHHHHHH--------EEEEEEEEE---------------------EEEE--HHHHHHHHHHHHHHHHHHHHHH-HH--------HHHH------H-------------------HHHHH------------------------------------------HHHH-HHHHHHHHHH-----EEEEE---H-------EEEEEEE-----------HH---HHHHHHHHHHHH---------------------
FREQ ----------------------------HHH-HHHH----HHHHHHHHHH-----------------EEE----------EE----------------HHHHHHHHHHHHHHH------HH----------------E---------------------------------HHH---------------------------------------EEEE----------EEE-----EE---------------EEEEE----------HHHHHHHHHHHHHHHHH-----HHHHHHHH-----------------------HHHHHHHHHHHH-------EEEEE-------------EEEEEEE--------E--------E---EEEEE------HHHHHHHHHHHHHH-------------------------------------EE--EE-----H-HH----------------------------------------HHH-HHHHHHHHHH-----EEEEE-----------EEEEEEE-----------H-------------HHH------------HHHH-----
PSSM ----------------------------HHHHHHHHHHHHHHH---HHHH---------------EEEEE----------EE--------EE-------HHHHHHHHHHHHHH------HHHHH----------------HH---------H---------------------------------------------------------------EEEEEE-------EHHHHHHHH--------------EEEEE-----------HHHHHHHHHHHHHHHHH-----HHHHHHH------------------------HHHHHHHHHHHH---H---EEEEE------------EEEEEEEE--------E------------EEEEE------HHHHHHHHHHHHHHHHHHHHHH----------------------------HHH-------HHHHHH---------------------------------------HHHH-HHHHHHHHHHH----EEEEEE----------EEEEEEE--------------------HHHHHH-----------------------
23305056 Streptococcus_iniae ---------------MLHYYPSFNHILDELKGLSGNRTGILNQSQVPVCNHQHDVYLKSV-TGQIPDYHK----------QYIDELSQVSYHIIGYGSHYEEALIKYLGESIE------RYATIIA------GDLLSDRIVY---------ASYKELSQ----SNPVMPLEYLQVFTQEQIDQS---------CKLHMHMCEKMVTEDDV---LGWVKCPMFFEDK-ELYVPIQMLCIG---YKPNREVGEQYVIPGFSTGTASHKTLEAAMCNSLIEYIQIDS-----MMLSWHTK---KSL-VQK-----SLSMIQTFKLFWKKQDLVKT---AWYEIIPIDMTVGE----DNPLYTFGIIL--------KNK--YEEGP---YLLFGVQAGLDPKHTLLRGVMEAAAISYSYYYNLFYQKESLANIESDSPLFLDL----DSNVFY--YAHPKDQEHKWKAFEPLI------------SGEICLSDLKNNAGQ----DKKEN-LKILLAYTKKVSPN-AVFLDITPPEASEKGWYVTRVLTPELLEMCIPAFPF---ANHPRMRQFGGV------------TNEFVHPMP---
70606349 Sulfolobus_acidocaldarius_DSM_639 --MRLEEFINEFIGPVFGYVAEKYDNVIITRLLNYVNYNILESHIG-----------QGWIRSSIEVLTP-------PQVLPLLKYLSNVVPAGGKGFTEEESLEGAIGEFLE------RFYGAFTLF----DDESIIFGRI------------GDLM-----TKYEIFPITYKFFSTEQLQKL---------------LIFRDYNENV----MLSLTRAKYYKGS-DVYIPVQITYLL---NLIRPGEDL--IAYSTTGGLAFHKDFESAFIHGLLEYLERDT-----INISWISR---IPP-KRI-----RLP-----ERIRRKLKVLED---RNITCLSFPGEF-------KGLFVVGCLG-------------FINDL----YVAGAGADITLEEAIRKAVFEVYQSIS---SFSKITDEEIKMARNLKPDYLT-----DFGLVPLYYSFVKTNFLVEYLRS---------------LQSITYEELER--------EENLS-YKSLIDIILGKNYY-IIYKDFDIEKYLGEG-KLVRVIVPDLTPAHIPNLPF---LGHKRYYTIRKE----FNLSNVELFVEEPVPFP---
34556866 Wolinella_succinogenes_DSM_1740 ----------------------MEKLTPLKGKDAPLERT-LEVIKEALGKAGFEIIEKECANPLSELFWV-----------FIQDKNHPSFFSNGKGYSKKAALASAYAEFAE------RAFSGFFFQELYLGDEEGIYLAK------------DEVLARS--IAEVLNPKWRRFYSMEGSLGS---------------RGWIDFQTSHQDH-ILALPFKRLGGEE-GLLFPQALL-----------------HNLYASNGIAAGNTLQEALVQAISEVIERAV-----RFEVIAKG---YAL-PDI-----PMEVLAQHKEACSVVEALQG---LGYEVRLKDASL------GRSWPVVVALL--------INP--KDAGA-----MLLFGAHPNFEVALLRTLSELLQGRDPHRGFKGLEIPALEVEECAD----------SRNLES--HFINSTGKIPWRILEE--------------KSDFAFEPWGV--EG----DREAE-LEYLARLLERFGLE-VFYKDHSRL-----GFFVVRVVIPSFSEVYPLEDMKEANMNEGKFFRAKV-----LAW--ESLEGEALGALLDDL
157737725 Arcobacter_butzleri_RM4018 -----------------------MNLLSKNSPVEKS----ILKMKAVLNDVGCEASFSQE-KNPLKNCFS---------VNLASNEAPNHIYSNGKGVISQASIASAYGEYIE------RLQTNNFF-----IDFHLPNRKY------------YPDEVAFEFGGDYLNKELKKIYNPNKDLED---------------KDLVDFNSDYMDK-IVALPFINQTNSK-KTYIPINIL-----------------SNLFASNGLATGNTANEAKVQALSEIVERYV-----KFKIIKNG---FSL-PTF-----PTEVIKSFPKVYEDVQSLKK---LGYIVEVLDASL------GGNFPVTAISL--------INP--KNSTL-----FVSFGSHPILEVSLERTMTELMQGRD-LTNLDGFEIPTFDMELVSN----------NFNLEA--HFIDSNGKLGFQFLNK--------------IKDFEYFPWKYEGN-----SSEEE-YEFLFDILKSQDRD-IYLREYTYL-----DFYSCQMIVPDFSEVYPIDDMI---YNNKNQGKLIRD----MVLNFENYDLNDILDSIDSL
78776315 Sulfurimonas_denitrificans_DSM_1251 -----------------------MNILSKEAPLEVS----IKKMKNVLKSVG-CETIVSKEHHPLQNCYS---------LNLSSTEAPSHIYSNGKGSLEDSALASALGEYIE------RLQTNMFF-----SDFYLPRRKH------------YPDEVEFELDGDFLSEELFDIYDPDGELLG---------------DAFVDFNSDSKK--IISLPFKKLSTNE-TIHFPVNIL-----------------HNLYVSNGLSAGNTPKEAQVQALSEIYERYA-----KFEIIKNG---YAL-PKF-----PQSVIESFSKLNEDISALRN---LGYIVEVLDASL------GGAFPVTAISL--------INP--KNSTL-----FVSFGAHPILEVSLERTMTELMQGRS-LDTLNDFETPTFDMSIVSD----------SFNLES--HFVDSNAKLGFAFLSS--------------KKSFEFSAWKY---D----TKMDE-LEFLTNIASDMGKE-IYTREYDYL-----GFYSCQMLIPSISEVYPIDDLA---YNNKNSAKAIRD----MVLNFSDYDAEDILDTIVSL
51246875 Desulfotalea_psychrophila_LSv54 -----------------------MNFLSKDASLQES----ITKMKAVLADAGCETTFSQE-KHPLQHCYS---------VNLTSTEAPEHIYANGKGILSEASMASALGEYIE------RLQ-TNNFF----TDFHLPNRSY------------FPDQVAFEFGGPYLNDELRLIYNPTGELED---------------EDLVDYNSDQEER-IIALPFAKKSNGE-TVHFPLNVL-----------------ANLYVSNGLASGNTPQEAQVQALSEIFERHA-----KIEIIKNG---YAL-PKI-----PDETVQALPRLQSDVLALRK---LGYIIEVLDASL------GGQFPVTAISL--------INP--KNASL-----FVSFGAHPILEVALERTMTELMQGRE-LDNLDAFEVPTFDMNLVSD----------SFNLES--HFVDSNGKIGFGFLRS--------------TKSFSYTPWDYK-GE----GCEAE-LKYLTAILDKMGKE-IYLREYSYL-----DFYSCQIIVPEISEVYPIDDLL---YNNKNRGKWIRD----MVLDFANYDPENILETIDEL
120597575 Shewanella_sp_W3_18_1 ---ETVENLDADANAMLMGHPEGESSTYILGKDLPLEQT-IANMTAMLADLGMKIEISSW-RNIVPNVWS----------LHIRDAASPMCFTNGKGATKESALCSALGEFIE------RLNNNFFYNDQFFGVEIANSEFV-----HYPNEKWFALEEDDSLPAGILDDYCLEIYNPDEELCG---------------SHLIDTNSGNIKRGICAIPYTRKSDGE-TVYFPSNLI-----------------ENLFLSNGMSAGNNLNEAHVQCLSEIFERAV-----KRQIIEQE---IVL-PDV-----PMSVLEKYPSILAGINGLEE---QGFPVVVKDASL------GGQFPVMCLTL--------MNP--KTGGV-----FASFGAHPSFEVALERSLTELLQGRS-FEGLNDVPKPTFNSMAVTE----------PENFVE--HFIDSTGVISWRFFSS--------------KHDYEFCEWDF--SG----TNEEE-AERLFGILEDLGKE-VYIAEFTDL-----GASACRILVPDYSEIYPVDDLIWDNTNKALAYREDIL-------NLHSLSTKQLANLVNRL
118594653 Methylophilales_bacterium_HTCC2181 ---EEVENLDIDAQSVLALKSATDATTFITGKDLPLEKT-IANMSGILADLGIKIEIASW-RNIIPNVWS----------LHIRDAHSPICFTNGKGTTKEGALASALGEFIE------RLSNNHFYAEAFWGEDMANLPFV-----HYPNEKWFKPGPDDSMPVEILDEYCLKIFNPDGELLG---------------SHLIDTNSGNLQRGICSLPYVRKSDGE-VVYFPSNLI-----------------ENLYVSNGMSAGNTLAETQVQCLSEIFERAV-----KREIIEGE---MAL-PDV-----PYEVLAKYPGILAGIHGLEE---QGFPVLVKDASM------GGLYPVMCVTL--------MNP--RTGGV-----FASFGAHPSFEVALERSLTELLQGRS-FEGLNDLPPPTFVSNAVTE----------PNNFVE--HFIDSSGIMSWRFFSD--------------KSNFSFVEWDFSNKGKS--SNREQ-AEALFNILQSKGKE-IYMATHNDL-----GAMSCRILVPGYSEVYPVEDLIWDNTNKALLFRADIL-------NLHRLDNNSLAALLDRL
26990331 Pseudomonas_putida_KT2440 ---VIEVVDNLDADAQGLLMPVSDTSTYIPGKDLPLEQT-IANMSGILAGLGMKIEIASW-RNIVPNVWS----------LHVRDAQSPMCFTNGKGATKEAALASALGEFIE------RLNCNFFYNDQFWGEDLANAPFV-----HYPNEQWFKPGPRDALPAEILDEHCLAIYNPDGELRG---------------SHLYDTNSGNTARGICSLPFVRQSDQQ-VVYFPSNLI-----------------ENLFLSNGMSAGNTLAEAQVQCLSEIFERAV-----KREILEGE---LCL-PDV-----PQEVLAKYPAILAGIQGLEE---QGFPVLVKDASL------GGEFPVMCVTL--------MNP--RTGGV-----FASFGAHPSLEVALERSLTELLQGRS-FEGLNDLPQPTFESHALTE----------PNNFVE--HFIDSSGVVSWRFFSA--------------KADFEFVEWDFSGHGED--SNQQE-AATLFGILEDLGKE-VYMAVYDNL-----GATACRILVPGYSEIYPVEDLIWDNTNRALSFRADIL-------NLHSLDSRSLKLLLKRL
56477039 Azoarcus_sp_EbN1 ---EEVENLDADAQALLMLNPASEASTYIAGKDLPLEQT-IANMSGVLAGLGMKIEIASW-RNLVPNVWS----------LHIRDAHSPMCFTNGKGATKESALASALGEFIE------RANCNHFYNDQFWGEDIANAAFV-----HYPHERWFKPGRKDALPTGILDEYCLEIYNADGELRG---------------SHLYDTNSGNIQRGICALPYVRQSDGE-VVYFPTNLI-----------------DNLFLSNGMSAGNTLAEAQVQCLSEIFERAV-----KREILEGE---IAL-PDV-----PHEVLAKYPGIQAGIQALED---QGFPVLVKDASL------GGEFPVMCVTL--------MNP--RTGGV-----FASFGAHPSLEVALERSLTELLQGRS-FEGLNDLPRPTFESNAVTE----------PNNFVE--HFIDSSGVVSWRFFSA--------------KADFDFVEWDFSGQGEN--SNADE-AATLFGILEDMGKE-AYMAVYDQL-----GTTACRILVPGYSEIYPVEDLIWDNTNKALAFRDDIL-------NLHRLDDASLQALLERL
77974842 Yersinia_frederiksenii_ATCC_33641 ---------------------MTQTFIPGKDAALEDS---ISRFQLKLSDLGFNIEEASW-LNPVPHVWS----------VHIRDRDCPLCFTNGKGASKKAALASALGEYFE------RLSTNYFFADFYLGKGIAEGDFV-----HYPNEKWFPIPEDDLLPEGILDKRLLAFYDPEQELLA---------------SDLVDLQSGNAKRGICSLPFTRQSDLE-TVYIPMNII-----------------GNLYVSNGMSAGNTANEARVQALSEVFERSV-----KNRIIAES---ISL-PEI-----PVEVLNRYPGVVEAIAKLEE---EGFPILSYDASL------GGAYPVICVVL--------FNP--ANGTC-----FASFGAHPDFGVALERTVTELLQGRS-LKDLNVFTAPTFDDEEVAE----------HTNLET--HFIDSSGLISWDMFKE--------------DADYPFVDWSFKG------TTEEE-FATLMAIFKQEDAE-VYIADYEHL-----GVYACRILVPGMSDIYPAEDLL---MANNTMGVHLRD--TILALPDSDWQPEQYLELIQKL
15800766 Escherichia_coli_O157H7_EDL933 ------------------MIFMTQTFIPGKDAALEDS---IARFQQKLSDLGFQIEEASW-LNPVPNVWS----------VHIRDKECALCFTNGKGATKKAALASALGEYFE------RLSTNYFFADFWLGETIANGPFV-----HYPNEKWFPLTENDDVPEGLLDERLRAFYDPENELTG---------------SMLIDLQSGNEDRGICGLPFTRQSDNQ-TVYIPMNII-----------------GNLYVSNGMSAGNTRNEARVQGLSEVFERYV-----KNRIIAES---ISL-PEI-----PADVLARYPAVVEAIETLEA---EGFPIFAYDGSL------GGQYPVICVVL--------FNP--ANGTC-----FASFGAHPDFGVALERTVTELLQGRG-LKDLDVFTPPTFDDEEVAE----------HTNLET--HFIDSSGLISWDLFKQ--------------DADYPFVDWNFSG------TTEEE-FATLMAIFNKEDKE-VYIADYEHL-----GVYACRIIVPGMSDIYPAEDLW---LANNSMGSHLRE--TILSLPGSEWEKEDYLNLIEQL
161503898 Salmonella_enterica_subsp_arizonae_serovar_ ---------------------MTQTFIPGKDAALEDS---IARFQQKLLDLGFHIEEAAW-LNPVPNVWS----------VHIRDKECALCFTNGKGATKKAALASALGEYFE------RLSTNYFFADFWLGETVANGPFV-----HYPNEKWFPLTENDDVPEGLLDARLRAFYDPENELTG---------------SQLIDLQSGNEARGVCGLPFTRQSDNQ-TVYIPMNII-----------------GNLYVSNGMSAGNTRNEARVQGLSEVFERYV-----KNRIIAES---ISL-PEI-----PAEVMARYPAVMESIATLEA---EGFPIFAYDGSL------GGKYPVICVVL--------FNP--ANGTC-----FASFGAHPDFGVALERTVTELLQGRG-LKDLDVFTPPTFDDEEVAE----------HTNLET--HFIDSSGLISWDLFKQ--------------DADYPFTDWSFSG------TTEEE-FATLMAIFAAEDKE-VYIADYEHL-----GVYACRIIVPGMSDIYPTEDLW---LANNNMGSHLRE--TLLSLPGSAWNKEDYLNLIEQL
74316630 Thiobacillus_denitrificans_ATCC_25259 --------MLSVMTSIDDAMNAPEHFIPGKDASLEAS---IATLHAKLEAIGFHVEERSW-LNPVEGVWS----------VHIRDRDCPLLFTNGKGGSELAARASALGEFFE------RLSTNYFWTHFYLGDTIANRHYV-----HHPEERWFELGDGNAWPKGLLTPELQRLYDPDRAVRA---------------AQLIDLNSGNADRGICAIPYQRLADGE-TVYFPVNLI-----------------GNLYVSNGMSAGNTLKEARAQALAEIFERNV-----KFRIIRDG---LCL-PDV-----PAAVIDRYPRIAAGIRGLRE---AGFGILVKDASL------GGRYPVMNVTL--------LHP--DDQGC-----FASFGAHPRFEVALERALTELLQGRA-LDSLEGFPAPGFDESEIAD----------PQNLEI--HFVDSSGVISWRFLRD--------------TPDFEFVDWNFAT------TTDED-YRWSVDALHAEGHE-IYVADFTHL-----GVYACRILVPGVSEIYPFEELE---FENNSVGNLIRP----ALARLPELSDDECAELLDLI
71908545 Dechloromonas_aromatica_RCB --------------------MQQEHFIPGKDASLEHS---IATMQAKLLARGFDIEECSW-LNPVDNVWS----------VHVRNRACHLMFTNGKGATRLAAQASALGEYFE------RLSCNYFWNHYYLGDAVANGEFA-----HYPRERWFPVTGSDW-PSELLTPELQAFYNPEGNIPA---------------EALIDVNTGNFERGICAIPYVRQRDGA-EVFVPVNII-----------------SNLYVSNGMSAGNTQAEARAQALSEILERHV-----KFKVIAEG---ICL-PDV-----PEAVIARYPTIAAGIQGLRD---AGFGILVKDASL------GGKYPVMCVTM--------LNP--KDQGV-----FASFGAHPRFEIALERALTELLQGRA-LEALDGFPPPGFDLDEVAS----------APNIEI--HFVDSSGIVHWNFFGD--------------TPDFDFADWNFNDLENG--KTADD-YTWLAERIHDDGHD-IYVADFDHL-----GVYACRILVPGMSEIYPIDDLE---WENNSNGAAVRP----AILNLAELDDDQCGQLLDLL
89901342 Rhodoferax_ferrireducens_T118 --------------------MQTQNFIPGKDASLEST---INNHQTRLQALGFHIEERSW-LNPVDGIWS---------VHIRDRDCP-LMFTNGKGATRLACLASALGEFFE------RLS-TNYFW----THYYLGPDIANRPYVHYPQERWFAPGEDGSWPPELLNADLHRFYNPEGGIEA---------------SSLVEFNSGNAERGICAIPYVRQRDGA-VTYFPVNVI-----------------GNLYVSNGMSAGNTQAEARTQALSEIFERHV-----KARIISEG---ICL-PDV-----PQAVIARYPRIAAGIAALRA---AGFGILVKDASL------GGQYPVMNVTL--------LHP--EDQGC-----FASFGAHPRFEIALERALTELLQGRA-LDSLAGFPAPGFDLEEVGS----------STNIEI--HFVDSSGVIHWKFLGD--------------EPDHAFVDWNFSN------TTAED-YAWAVDRIHKDGRD-IYIADFTHL-----GVYACRILVPGMSEIYPVDDLA---FENNSVGNSIRE----AILNLPDLDDEECSDLLDTL
55377824 Haloarcula_marismortui_ATCC_43049 QRRFLPVPGCDCGGTQGHSLGDGRQTAPDSEALSRAELG-LDDRVGIAT----EVGEVES--FPAPYYLS------TLADTAGFSDVSAAAKAAGVAIDWDTAFMKALGENYE------RYAAGVYRE----GNL--------------QHGTVADV-------PAAVTPDTFV-------------------------RDEAEWDESHA---LPWVPAENLLTDE-QRSLPAETVHYP---PPSNA------VRPATTTGLGLGNTVTEALLTGLYEVIERDA-----AMLSWYST---FDP-LRV--------AIDEHEQYETLRRRATS---EGLDVTALLLTQ------DVDVPVITVAL--------A----QDEWP---RFALGTDADLNPGAAAVGALEEALQNWM---ELDSMGPEAAMDA--------------QGAIGR--YAKSPGEAADLTAS----------------ETAVPLDSLGPDVDL----SGEAE-LETLCDRAADAGLA-PYGTRLTTRDLEQLGFEAVRVVCPSA-QPLFFGESF---FG-ERAETVPAD----LGF--EPRLDRDHHPFP---
153894529 Halorubrum_lacusprofundi_ATCC_49239 ERTLLPVPGCDCGADPGDALPREHQERSLSDAIDRAERA-VDPRIGLLS----EVGEQES--FPVPYYVA------RVADTTPFSDARAAEFGGGVDAGWDAAFMKALGEGLE------RYAAGVYRG----ASFTR--------------------------APAANVPNPVA---PDAFVRP---------------ESAEPYARDDR---LPWVTGEHLGTGE-VASLPAEFVHFP---PPENR------YRPAITTGLGLGNSGPHAALSGLYEAIERDA-----TMTSWYST---ADP-LGI--------EVDD-EGFAELEKRART---ESLSVTPLLVTT------DIDVPVVAVGV--------HR---EGDWP---RFAAGSGADLDPAAAARSALAEALQNWT---ELRSMGPDAAAKQ--------------GAAIGR--HADFPAETRAFFDADAT-------------VPAESLGEPEL--------SGGDE-LAAVVDRAEAVGLE-PYVARTTTRDLAALGFEAVRVLVPGA-QPLFTGDPF---FG-DRARDVPRS----MGF--EPDLEKAYHPFP---
76801943 Natronomonas_pharaonis_DSM_2160 ARQVLPVPGCSCGSRAGRQLELTHADRTLDESLSLAEGA-FDERVGPIT----SVGEAES--FPVPYYLA-------SLAATPFSDADAPDHAAGVGLSWDPAFMKALGEGLE------RYSAAVYST-----------------------------------DRLLVDPDRRVPAD----------------------AFVAPEPPGEV---AYWYPAEHLETGE-RTAIPSELVVFP---PPETR------IRPAITTGLGLGNGTVEALCSGLYEVIERDA-----AMVSWYST---DDP-MAL--------AVED-EGYRTLAARAGS---EGLSATALLLTQ------DVDVPVVAVCV--------HR---EGEWP---RFAAGSAADLDPAAAARGALEEALQNWLELRRMGRTQAESE-----------------SGAIGD--YAAFPEAARAFVDA----------------ETTIPAESVGPAERP----SGKAE-LTALVDRVSAAGLD-AYGARLTPRDIEMLGFEAVRVVVPSA-QPLFTGDAY---FG-DRARRVPAE----LGF--EPQLDRPYHPYP---
78357391 Desulfovibrio_desulfuricans_G20 --------MIQLSSCPKGCSQDLDKAVPAAETVRMARGRLQSLKLDLLAETR-RVD-TGR--LGIPVFLS--------VCGHDARTVMPTRKQMGKGASASQAEASALMELVE------RYSYFRFMQ----QTETVFSGTW------------SEAEEHF--RGQIMPVEQLLLSVGDTSDAA----------------AVRPLLDLVR---WQFCPATQINSGQ-RIALPLDWFRTL-----------------NEFNGSSAGNTYEEAVLQGLCELVERHV-----CCIAARDR---QPQ-PTI-----MPQSTDD-AVLLGLLDKFTA---NGIEVLLKDFSM------ELPVPTVAALA--------YDPSTLGTRS---EIVFTAGTAATPAKAAIRALTEVAQLAGDFETGSCYEASGL-------------------------PKYTSEAETGWLKT----------------GPQVAFSDLPHIGDN----DIFAE-LTHLTAKLGMDGFH-AYCIDTTAPEL---DIPAVYTIVPGF------RFRERDKNASPGLFIGRIL----SEQYPPEAAADGLEQIRKVY
51245807 Desulfotalea_psychrophila_LSv54 -------------------------MKNLDINIVS------------------EVRRIDNGRLDIPVYFS--------VCGDDASQYTGTKKQMGKGASPIQSEASACMELAE------RFSFFSFSK----NADNFLLGDY------------EEMRAA---GYPVLDMEHLLKSVHDTHTTV---------------AQLEKLLAGIP---MQWTWATKMTGEEGEVLIPFSWFFAI-----------------NEFNGPSAGNTQEEAALQGLCEIVERDV-----CSRINRDK---LPT-AKI-----DVETIKD-PVAVELLEKFAK---NNIEVYLNDFSL------ETGIASVGALA--------IDRSTFPEKS---EIVYTAGTTPNPEKAIIRAITEVAQLAGDFNTGSNYIASG--------------------------LPKPLSMSEVTYLTET--------------ADQVTIDEMVDISDD----NIYTE-VKNCLDSLKNNGFD-VYMIDVCHPQL---QIPALYTIIPGA------HFRERSMICNAGLFCAKLL----VERIEDPAEQEVKLGEMSVL
87119842 Marinomonas_sp_MED121 FSDQINSPIRLNACISQFNIDGGSRSISASETVKKLMPL-VSPITGVINHLE-VIGETPE--SPIKIYRTGFFKTNNKSTEFEFDRNSFVQICLGKGVSHAQSKASALSESIE------RYA-ALYQ-----FDVSLLQSSK------------SNMLAS---GKQLYDFQSLVPYSANQYHKF--NTSNHP--DAALKQAAKPYK-DET---IHWLPTWSLTQEE-QVYVPLSQCFSN---IPFSDDE----FGRWHSNGCAAGNTLEEAILQALFELIERDA-----TAIWWYNK---LVC-PKF-----DLTGLNP-ENLSKLDQSLSPSPDLGHEYWVLDLTS------DLGVPVMGAIG--------KDK--KSGGL-----VMGFGCHLIPEMAAQRALTELCQLIP-------IRDQNAA------------------------PFDFDEIEEGEYLFGS---------------LLGESNTYAIKPSQ----DIKED-ILSIVAQLKTKNME-VLALNYSRAHI---PLFTAKIFVPGL----CHIWPQ---LANERLYQAPYA----MGYSGIANTEQSINQQPLYI
160899802 Delftia_acidovorans_SPH_1 MALRQRERIAPVPGTHAARADGGWRSVPAETTVQRLSQH-VSPLTGVIARVT-PLTAETD--EALTIYRS--EIFRTPAPGSTSLAGSGTQLCLGKGLSAVQARASAMCEAVE------RYA-AFHQ-----GDEAVVIAPA------------AEL------DAPCIAPTELARFSERQTAGF--------ATDKPPHAVAPSTGQGEP---LWWAPAWSLTADA-RRYLPLAFCLAH---APAQSQY----HVGWTSNGCAAGNTREEAILQGFMELVERDA-----AAIWWYGQ---IRR-PAI-----ALQGID--QATRQRLDRSCG---PQWSYWLLDITH------DFGIPVVVSVG--------RHAD-TGQWA------VGFGCSLDRALACERALTEISQLIA------------------------------AGKSFA--VPEPLQAFLHPADSAD--------------APPQQPASLSGHTPDTTPPDIAQA-IARCVDIARGLGLE-TIVYDYSRPDI---PVHTVKIVIPGL----CHIWPE---LGNPRLRNVPVA----LGWHSRPLQESELNPLALYV
120611723 Acidovorax_avenae_subsp_citrulli_AAC00_1 MARQARQPVQLRDVHALPGARGGSRTVLPDTTVQAVQPS-VGAWAGVVTECS-PLPLPEA--GAITVYRS-----AFHPAGLQEGGPVAARWCLGKGMTAAQAQASALCEAVE------RYA-AGFQ-----GDEAWTEARE------------DGL------PAPAFGPRSLVFISDRQRARA--------GAGDDRVRRTLPHPPGVP---LAWTPAWSLTREA-PCLLPLAHCYAG---VPGRWSR----YGEWNSNGCAAGNGVEEAVLQGLLEVVERDA-----TAIWWYNE---LAM-PAF-----DLGRADP-EHLRRVRSTLGS----GWSFWALDLTH------DLCIPVVAAVG--------RRA--DGDWA------LGFGCSLDADMACERALTELVQLVA---VGKTLPG----------------------------HWNGLRRASPEFLLPEGG------------DNRGIASSVRARAAADGRGGIRAD-IAACVEAARRCGLE-VVVHDYSRPDL---PLRTVKTTLPGA----CHIWPE---LANPRLSRVPVA----MGWRDAARDEGDLNPWPLYV
167561541 Burkholderia_oklahomensis_EO147 EQAERPVTLAAMDGGEGARREGGYRTLAASELFKRYGHL-ISPVSGPIAYLH-PMPARNA--GMRHVYVA----GYLVCPQSAPRENRFDKLCSGKGASDAQARASALAEALE------RFS-GVYQ-----GDEATLRGSL------------AELSAQAPPGGGPIDVNALQQYSDRQFERR---ARHNATTDDPRKQVPQRFTPHSV---IDWTPAWSIATGV-RRLVPLGYCYAE---APASSGAA---YCVHNPNGCAAGACIEEAILQGLLELVERDA-----VAIWWYNE---LCR-PSI-----DIASFGD-PYFDALVAEYAS---LGWRLWALDITH------DLRIPVFVALA--------R----EDATG---RFSIGFGCHLDSRIALQRALTEVNQLLD---VGASAPPP----------------------------WDVDKLSSDAFLHPDAA------------LPPTRATGATSAPRAAA--DLKGD-IGRCVARLSAAGID-TLVVDKTRPDI---GLPVVQVIAPGL----CHFWPR---FGARRLYSVPVL----EGWRERPRDEDELNRALLFL
167568773 Burkholderia_oklahomensis_C6786 EQAERPVTLAAMDGGEGARREGGYRTLAAGELFKRYGHL-ISPVSGPIAYLH-PMPARNA--GMRHVYVA----GYLVCPQSAPRENRFDKLCSGKGASDAQARASALAEALE------RFS-GVYQ-----GDEATLRGSL------------AELSAQAPPGGGPIDVNALQQYSDRQFERR---ERHNATTDDPRKQVPQRFTPHSV---IDWTPAWSIATGV-RRLVPLGYCYAE---APASSGAA---YCVHNPNGCAAGACIEEAILQGLLELVERDA-----VAIWWYNE---LCR-PSI-----DIASFGD-PYFDALVAEYAS---FGWRLWALDITH------DLRIPVFVALA--------R----EDATG---RFSIGFGCHLDSRIALQRALTEVNQLLD---VGASAPPP----------------------------WDVDKLSSDAFLHPDAA------------LPPTRATGATSAPRAAA--DLKGD-IGRCVARLSAAGID-TLVVDKTRPDI---GLPVVQVIAPGL----CHFWPR---FGARRLYSVPVL----EGWRERPRDEDELNRALLFL
27379649 Bradyrhizobium_japonicum_USDA_110 NPRRSPALVEIAEGKKLVMTSGGYRTMTSRATVSRFRKH-VSPLTGVVT----RLERIEADLPMNTNYFA-QHNFSAPAHSIDQLRSGLSGGSFGKGSTAEQGEASALMESIE------RYS-GIFQ-----GDEIRTTRRF------------VDFA-----PGDALLPNDVQLFSETQFKNR------FLQQPDDPHPVPEPFDPSTR---TEWSPVSSLRDKR-FKYLPTGLLYFF---YG---------GFHTDSNGCAAGNTRDEAIVQGFLELIERDA-----YAIWWYNQ---VQR-AAV-----DLEQFDD-FYVRDLQAQFAD---AGRKLWVLDVTT------DLGIPTYVAIM--------HWM--QNGHE---NIEFGSGAHFDRHIALLRSLTELTQFMS----VGMMGGASG-----------------EKPTLD--GVTPLRLENYPFLTPSDRPI----------VPPAPSLKLHD--------NTRDQ-VIACVEIAARAGYD-FLVLDQTRPDV---EVPVVRVLVPGL----RHFYRR---FAPGRLYDVPVK----LGLLDRPRLESDLTSFLPHT
124003741 Microscilla_marina_ATCC_23134 VTIKSPQPITLQPVSVASTL-GGYRAESPEVSFQKYKHH-ISPISGIISGLK-PYGNTNH--ADIHNYSS-GRNLALQSVSMFWLNHHLRSGNGGKGKTDIQAKMGAVGEAIE------RYS-LMYQE----GERYTIKAAL------------QDL-------PEGIHPNQCMNYSKAQMQSR--DTTNIS-SAKFYELIPVPFDASET---MDWTPVYSLTNQK-FKYLPACFCYAQ---YPAKDESQL--YAYPDSNGCAAGNTIEEAILQGFMELVERDA-----TAIWWYNR---LKR-PAV-----DLDTLDN-PYIDKMRAYYTS---INRSLWVLDITN------DLGVPVFVAVS--------HCL--KGNKE---KILYAFGAHLEASIAVERAVIELNQLLPIGTSDKYLTQ--------------------DQAFID--WLDTQTLTSNGYLLPKEG------------ATKNIQTDYPRLCKP----TIYDS-VKYCIATARQQGLE-TLVLDLTQPDI---VLPVVKVIVPGM----RHFWRR---TAPGRLYDVPVK----MGWLSRPLAEEALNPISIFI
78186744 Pelodictyon_luteolum_DSM_273 AKEPRAEKVVLASGKATFMQDGGHRTVAPETTLEKYERF-VSPITGVVNALV-KLP-QSN--GTVHVYLA-GHNSAVRLERLEDLKNGLRNASSGKGASEVQAKASALCEALE------RYS-GESH-----GQEIRISGSY------------RTMLAE--HGGRLIHPNAVMHYSERQYAER--KTWNGR--KSKFNVVPEPLDADAE---IDWTPVWSLTDNC-HKYLPTKLLYFK---AQAGASSEAF-YSVGCSNGNASGNTLEEAILQGFFELVERDA-----VAIWWYNM---IRK-PGV-----DIDSFEE-PWFQELRSHYHS---IGRELWVLDITT------DLDIPAFAAFS--------ALR--NSARE---EIIFGLGCHLDPRIALQRSLAEMNQMLGLADAKESDGSMRIE----------------DQEVLS--WLTNATRENQPYVTPEPT------------VPLRKRSDYTLQHSG----ELLAD-IETCRRRIEDAGME-MLVLDQTRADI---GMPVAKVIVPGL----RHFWAR---FGPGRLYDVPLA----MHWLTRPRAEEELNPIPIFF
147678664 Pelotomaculum_thermopropionicum_SI ALEAAGLRTGLRESARLWLVLTDDYQREELAAVNQAALQGARPWLLVRAGGP-QLWLGPLFIPGETGCWQ---------CLSSRLKRSLRSSSAGKGVSEIQARASALCEAIE------RYS-GELS-----GGEVRVTCAL------------KDWP-----PGEAYHPNDIMLYSAGQYARR----EAWNKRGSRFNRVPEPFTPDPV---VDWTPLWSLTEER-HKYVPTQLVYYG---APARAGDDTF-YAFGCSNGCASGNTLAEAVLQGFFELVERDA-----AAIWWYNR---LPR-PGV-----DLVTFDE-PYLLELAEHYRTR--YRRETWALDITS------DLGIPAFAALS--------RRL--EGPEE---QILLGLGCHLDARIALQRAFAEMNQMLG--VASSAGKGDRQPLE--------------DRETLT--WLREATLTKQPYLAPDPA------------QPPRRLGDYPKQHSG----DFLQD-IAYCRQIIEARGME-MLVLDQTRAEV---GMPVVKVVVPGL----RHFWAR---FAPGRLYEVPVG----MGWLKEPLREEDLNPVPIFF
78042201 Streptomyces_sp_TP_A0584 MARQHQSPVRLRSMPKVTLVDGGHRSKDPQRMLDLHGHL-ISSALGPVTGLQ-KVP-SVW--PGFHAYTA-GQNFAIPMSRPGDLRVGLRSQSCGKGMSDLQARASALGEALE------RYS-GVYQ-----GDEARITASY------------DDL------GDRAIAPNDLALYSARQFDER--EEWNNR--DVHFHRVLAPFDTAAP---IDWTPVWSLTMQR-HRYVPTASLFYG---YPLDRDHQ---YAAADSNGSAAGTSIEDAVLQGFMELVERDS-----VALWWYNR---VQR-PEV-----DLQSFGE-PYFLEWLAQYRS---LNREAWVLDLTS------DFGIPVMAAIS--------RRI--DKPAE---DILIAFGAHFDARIAVGRALTEMNQFLP---AVVHAKPEGGGYTYP------------DPAQQH--WWQTATLANQPYLRPLS-------------APRRTAGDFPVHESL----DLLDD-LHRAQATVEEHGME-LLVINQTRPDV---GLPVVKVIVPGM----RHFWPR---FAPGRLYDVPVK----LGWVSQQTREEDLNPIGVFI
159026417 Microcystis_aeruginosa_PCC_7806 SLNKTPLPVVLGHRKKAFTSDGGHRFCSPEETLRTYQHL-ISPITGIVRELN-KIQ--GN--ALVHTYVA-KHHFRSVFDDLDSLRQNIGGRSAGKGRTDSQAKASGFCEAIE------RYS-GVFQ-----GNEIREKANY------------QEL------GDKAIHPNKCMNFSEKQYQHR--EEWNGK-NQGWFQKVPEPFDETRM---IDWTPVWSLTAQD-FKYLPTGYCYYG---YPQSEPL----DCWADSNGCAAGNTIEEAILQGFMELLERDC-----VALWWYNQ---LVK-PSV-----NLESLNE-PYFEQLKQYYEG---LNRELWVLDITS------DLNIPCFAAIS--------PRK--EREVE---DILLGYGAHFDPKIAISRALTEVNQILP---NVLSFKEDGTTIYPPSA----------DPLAVK--WWQTARLSNQSYLVPDSK------------IIPKKSNDYLQLASD----DLLED-VKLCQRIVESKGME-MLVLDQTRPDI---GLRVAKVIVPGM----RHMWKR---LGAGRLYDVPVS----MGWLKEALTEDELNPFPMWM
158934371 Microcystis_aeruginosa_NIES_298 LHRQGFEPVKLVSRRKHFTHDGGHRAFTPEQTVQKYQHL-VSPITGVVTELV-RLTDPAN--PLVHTYKA--GHAFGSATTLRGLRNTLKYKSSGKGKTDIQSRASGLCEAIE------RYS-GIFQ-----GDEPRKRATL------------AEL------GDLALHPESLLYFSNTQYANR--EELNAQGSAAAYRWIPNRFDVSQA---IDWTPVWSLTEQK-HKYVPTAFCYYG---YPLPEEQR---FCKADSNGNAAGNTLEEAILQGFLELVERDS-----IAMWWYNR---IRR-PAV-----DLSTFDE-PYFVDLQQFYQQ---QNRELWVLDVTA------DLGIPAFAGFS--------RRT--VGTSE---RISIGFGAHLDPTIAILRALTEVSQVGL---ELDKIPDDKL-----------------DGESKD--WMLNVTVENHPWLAPDPS------------VPMKTASDYPKRWSD----DIHTD-VMNCVKTAQTAGLE-VMVLDQTRPDI---GLNVVKVIIPGM----RTFWTR---FGQGRLYDIPVK----LGWLDAPLAEEELNQTNIPF
152967371 Kineococcus_radiotolerans_SRS30216 -----------MNPPALRSLTVDHPVREDGDHRATER---FRDVLGERDRFQFPTYRLDT--VGVPSWWT----------IAATGAAGAAAIGHGYGATDADARRSSWGESAELGLLRRRVSTLEHRR----GTRAELVAEF------------G--------ADAVLDPPSVCL------------------------DAGSPYHPGSP---LNWLPLQRWGTGE-RVWAPADVVLRDADELPEGFVDDLPRLVTRHGNGLGAGDSLERAVAHGIGELLQRD------GNGTRFRA---LDT-GIVLDLGTDDELVAD-PVTRDALARLRA---QGVRVVPKLAND------WWGIVNVTVVG--------ADDDPLQPVM---VTAAGEAAHPDREVALRKAVLEFAAARS---RKAFTHGDLDAVRRISPPGYVERYAADPSTQEQ----RALRGMLGWLERDAAQLRELLEPVVLAERSRRRFDTLPTWNAPEGADEQRAL-AAHLVGLLRERGFD-VLVLDCSAD-----DVAVARVVVPGL-EVEIVSYGR---IGERGLADLLERGDGRTGLHGIAGLGVPGRDGVPA-
149124331 Methylobacterium_sp_4_46 ---MTSDTPRLRPSRPRPTRFGEKRVVEGLPADLPDAARAYLEVLPPGRVVGFPLAPLDR--TGVPTWFV-------SLFLDDPFFVGAMPSGIGYGATDAEAIIGSIAEIAE------NLMPSVALI----PRKKE-RGSY------------HDLARVFG-AGSVADPLTLGL------------------------PAGSPVGRDTV---LEWTEVVRARTGE-TVLMPLDIAATD---YFELSEDYVP-FTNLITNGLGAGPDVAFALGHGLLELLQRD------GNGLLFRA---LDQ-GVLL----DLAEGVG-PETRAMLDRLEA---LGIRAMPKFATD------QFGFANVYCVG--------YDLDPARAPAPIALSACGEACDPDRERALRKALLEFQAARV---RKTFGHGPLALARGITPPGYVDAFIETALPSLDKEESRALSAMLHWIEQPAETLRGFLADTVFSERARKPFAELPTAAAP----DGQAR-GRLARERLEAEGFD-VLYLDASPPGG---GVGVVKAIVPGL-EVETMSYYR---IGERNTAKLIARDHPLIRFGQESETLRPVRLTPEAL
115374475 Stigmatella_aurantiaca_DW4/3_1 --------------MSLKEAREAYRRAMPEGELELF-----------------RIDGLDR--LSVPVVAG-----------SLRAANGLWFLSYGYGATEEEAEVSALGELAE-------YVFTSQSM----STAPLFQGSY------------TELVRTHG-SEGVADPLTLGL------------------------PVGSPYQPDMP---LTWVEMRRLATGE-RVLVPEEYIVSY---PEQRQGRSAS-LITPITNGQGAGLSYSQALAHALLELLQRD------GNGLQFRA---MDQ-GTVL----DLEDARLSPAIGALLENYRR---AGIEVVAKLAST------EFGVANVYVVG--------NDP--NPGEQPLMVTSCGEAADPDRDRALRKALLEYASSRS---RKAFMHGPLEAVSRVAPAGYLDRFLPLLDLGLE--ESRALNSMMEWASMPVSVLRKLTASTLHC-RHKVRFDTLPQAPEAG---DPTLR-CEQVVEALHAAGFD-ILVADMPTADG---SAHGVKALVPGL-EVETLSYYR---IGERNVARLLARGDPLVGLGAPPQGALPVRLTAEAE
115376935 Stigmatella_aurantiaca_DW4/3_1 --------------------------MPAGELLLF------------------RDDGIDR--LGIPVVAS-----------SLRMEKGPWITSHGYGATEEEAMVSAIGELAE------EVFAEKTL-----AGLPRFHGSY------------TEMVRLRG-TRGVADPLTLGL------------------------PAGSPYQPDMP---LTWLEMKRLSTGE-PVLVPEEFVAIH---PGQLRGHSP--LILPITNGQGAGLSQSQALAHALLELQQRD------GNGLQFRA---MDR-GVVL----DLEEANLPPDIQELLERYRQ---AGIEIIPKLASL------EFGLVNLYVVG--------NDP--SPGEQPLMVTACGEAADPDRNRALRKALLEYAGSRA---RKAFMHGPLEAVARVAPSGYLERFLPQVDLRQE--EPRALQGMVEWASMPV-AALRELTTQTLQCRHKVRFANLPEAVTA----EAPSERCAQVVDGLLLTGFD-VLIIDLSPPDH---SIHVVKTLVPGL-EVETMTYSR---LGERNLSRLLARQDPLAGLGPPPEGAQRVRLTASAE
37520868 Gloeobacter_violaceus_PCC_7421 ----------MTETTDLYRMSSSLRVVALAETLQRARA--FASRLGIIRVT--DTTRLDC--IGIPVFAS----------IRPTALPGSLCVNAGKGLRPEEARVGAYMEAIE-------FAMAEYGR----SAVDYVMATP------------RDV------LDGRSRPEAILDFCP---------------------VFGAQITLDDP---MPCVEAEELLSST-RCLVPAELVYVP---APAVEGVQR--HFGSSSNGLCSGNSVWEASVHGLAEVIERD---------IQSFC---FLH-DTSVLV--DIASLP--PQPAALARQIGE---AGFTLRLRYVEN------IFELPYFAAYV--------MEP--DPVDA--VYICGGFGCHPFKEIAAVRAICE--AVQG---RLSFIHGGRDDLIERHR----------LLAQMN--GEQELAFSRKLAAKVSRP------------EGMIGFEAIGDRSGEVC--DLSSA-WEVLVAAIRKVGIAHVCRVVFTQPHD---PVQVLKLIVPRL-EMFDRSTRR---IGPRLRDHARFH----E-------------------
159185801 Agrobacterium_tumefaciens_str_C58 ---------------------MSATTASGQADASFFDPG-LLRRFGITRVG--DVTGLDI--IGIPVWFA------------ARPNSRGLSVSQGKGLFADQARLSAIMEAIE------GAVAEETRR---------HVTAF------------GSIEEMRNKGVPLIPFETVGRIDPDALDLR------------------------KE---RAWVKGTSIRQQQ-EVFAPYELIGMD---FRAEFPWDRQ-AFRMSSQGLAAGFEQDHAVLHALLELIENDASFL--VDTFETRA---ITPQPFL------LSAGMD-SLLDDLIQHLSN---IGLPPSFFDLTN------ALGVPVVMASL--------PRSLQAEDGP-ATRSAAGAACRPNTHAAAMAALLEAIQSRL-----TDISGARD-----------------DLSPLR--YQRDLSTSGPTASRAQ--------------PLRQMPADLNFPES-----DLSLPPWRQLAEHLFARGIEDIHVFPLETEVS---GLHVVRILASGL-APAGGGLQH---ISPRTLDHLLNL----GGT-----------------
108763910 Myxococcus_xanthus_DK_1622 -----------------------MRAPRDELSSRRFQQR-LAQAMGVTRVA--RVTGLDR--TGVEVACA------------VRPGGHILQVCNGKGLSYDDAAWGALLETAE------LWAAETV------VPDALVWGSR------------AELDGH---LGALWGADELGSAGAL--------------------VAPRLWSPHVR---CAWLEARELYSGE-PVWVPAQGLHVP----PAGSPALGPVAVAWTSNGSGAHPDAGRALLHALLEATERDQLARMMPEGWTEEV---VQR-RLLR----TPELLELAPAVEALAGPLRE---RGFGVYLFDATPAARTPGAVGLPVGAAVL--------VDL--EEGPV---PLTAGYACALTREAALLKALLEAAQSRL-----TDIHGAREDVAAA------------DREAAR--GFAEACAQV---------------------RPRRRAADMPDLGAK----GAAAGQVRQVLAKLQRAGFTRAAAVAMSSPVE---GLHVQKVVVPGM-----------------RISELL--------------------------
163765800 Anaeromyxobacter_sp_K -------------------------MAGIPRPLRDGRRDTLTHALGVTRVA--RLTGLDR--TGVEVASA------------VRPDGHVLQVTNGKGARFEDAALGALAEAAE------LWA-AERPG----PM---PLASA------------AELRARLG-EGAVIGPGAL---------------------------AGGGADPAWETLRVAWCQGVPLEGGA-PIAVPAQAVFCP---PPGGPLLGPA-VLTWTSNGMGAHPDPHRAALHALLEAVERDQLARALPDGFTERE---LAR-RLLD----PGGLAAAAPRTAALAASLEA---RGLRVHLLDLVPAGRRARGLGLPVAGALL--------GDP--GGPVP----LAAGYACRPGRDEALLAALLEAAQSRA-----TEIHGAREDVLHG------------DRASAA--PLAARCAAL---------------------RPSRRAAALPSLAAP----SPSAA-LRRIAGRLRAAGLGSAVRVALEGPP----GLHVVKIVAPGL-------------LRSELL------------------------------
91774002 Methanococcoides_burtonii_DSM_6242 -------MCHILIDRSLQYIEGTQRVLDEAATLENTQPH--LKRIGVTRIA--SITELDR--IGIPVFSA----------IRPSAADGAISIYSGKGASEGQARISAMMESFE------RCL----------AERVSVNADI------------DEEIA----ADEFIESSDKATEDHELLDVH-------------SLLLFEPITSDKL---VEWTKGWDLLQEK-EIYVPSNAVHHP---YDSPGMSAK--LFRSNTNGLASGNVIEEAILHGLLEVIERDA--------LSISE---FNRNPGK-----ELVLTENDGLSYELVKKFEN---AGVQIKLWYLQH------DTAVTTILAAT--------DDLELKDAAL----LVMGAGSHLKPEIAVRRAITEAAQSRV-----VQIHGAREDTDR-------------ESFVRQIGYERMKRMNRFWYDEGES-------------ITLDQINDISA--------STPAENIDVVLNELRKVADS-AIVVDLSRESI---GVPVVRVIIPGF-EQYTLDRER---VG-KRLRQGRKS----SASSEKPWKRQFGRNK----
154151517 Candidatus_Methanoregula_boonei_6A8 ---------MRISSCKKTYSNETQRAVPLAETLARIEP--KIPVAGITRVA--EITGLDR--IGIPVFSC----------IRPTAEDGAITVYNGKGATVEESRISGIMEGIE------RYSSEIHDR----KVRLDTYEML------------KD-------REPVINPADL--------------------------ILPAETQPGHV---LPWVEGWDIANDE-QLLVPAQAVFHP---LPRNFRQ----IFRTSTNGLASGNTREEAIFHALCEVIERDA--------WSLVE---ATR-DTGP----SVVNISD-PMLADMQKKFAD---AQVDVIVRDITS------DIGIPTMAAVA--------DDV--LLKDP--SLLTIGIGTHSNARIAVMRALTE--VAQS---RLTQIHGAREDTI-TAE----------LRKKMG--YDRAKRINGYWFK----D------------NGYVDYAALRSFDSD----DFARD-IRVVIEALKKQDLNRVIVVDLTREEV---GIPVVRVIVPGL-EVYAMDPER---RGERLRHAKNHR----LSRAKS--------------
163798599 Methanococcus_voltae_A3 -------MDNLQKNTKINYTLAAYRLCSPEETLEKIEP--ILKRIGVTRTA--RIDGLDR--IGVPVYSS----------IRPEAKEGAISVYAGKGATETQAKVSSSMEAIE------RYC----AE----QDEYTPLKST------------NNPKNPVNLYDLIIPTLNTLSKNDNTANNVNDGNTTNDDINNDNSIESSLNNSNLNISVVEWVEGYDIINNE-NVEVPANSVFHP---YEAKTGKW---LFRSNTNGLASGNSYDEAVFHGILEVVERDA--------WSISE---LSR-NTYRKI--NVSDAKN-PLIHEMLIKFRK---AKINVILKDLTS------EIGIPTIACIS--------DED--VLKDP--ALLCMGVGCHLDPEIAVIRALTEVAQSRA-----TQIHGAREDTVRAD-----------LIRKVE--YDRMKRIQRRWFNHKE----------------EINISELHNYASY----DLKKD-IETTKTMLKNNGFDKIIVLDLNKSTVD--DVNVVRVIIPKM-EIYAVDNAR---ISKNVKERIKKN----------------LMGTRTIV
150401270 Methanococcus_aeolicus_Nankai_3 ------------MYDSINYNVETYRVCSPEETWNKIKSLTKNINIEILE----RIDNLDR--IGIPVYSA--KRIVKSPENENDTKEKIVKYHYGKGATDIQAKVSAIMEAIE------RYSMGCLNE----PATKN--------------------------PENPIDLKELVLSKESYKNIN---------------QINNNINN------IEWTACHDIINDE-IIDIPVNAVCHP---TEGK-------LFKSNTNGIASGNTKDEAIFHGTLELIERDS--------WSIAEIYNKTH-TKI-----NTDGAKN-PIIHELMDKFKD---ANINVVLKDLTS------DIGIPTVAAVS--------DEP--VLKDP--ALLCIGVGCHINPEIAVIRALTEVIQSRA-----TQIQNKRDDTIRGD-----------IVRKVQ--YDRLIKVHRKWYGHKD----------------EINIEELPNNAKL----NLKKD-LNVIKNKLIDTGFDKLIVADLKKPEV---GIDVVRIIIPKI-EVYCMDRDRISPWIRERMKNIKN-------------------------
169195470 Rhizobium_leguminosarum_bv_trifolii_WSM2304 ------------MNSALHPAHYSDRIISPGETLSRVEP--FLARFGITRVA--RHTGLDD--IGIPVWCA------------YAPNSRSIVIAQGKGLTDLDAKVSTVMEALE------RAVAGE-------PFVKRVHGSC------------SRL------QAMGYQVDRLSCLTA---------------------VHKPDLGPDDE---TEWVAGIDILSGD-EIHIPFEAVVLD---RTRDA------RYWMSSDGLASGNSVEEAIFHGVLERIERDA-----QVLWQVGGEADLYA-GCV-----DPRGFED-GALNGLVDKIEA---SGLALRLFDITS------DIAIPCFTAMLGPGEFIPGSRHIYADRDIRLVEVTGGTGAHPSPVRAAIRAVTEAVQSRL-----TYISGARDDIS--------------PATFLR--SLPPLMRQAFDAVAAP--------------PAALRRDGAAGYRAR----NLTEL-LQQVLDALRNRGIASVIRVRLSDDTL---PFSVVKIVIPELENPEGERARR---FGTRALAKAIGF------------------------
162449061 Sorangium_cellulosum_So_ce_56 ------MRDPWCFPPSPKLDPRVDRVTTLEDAERCVRA--IAARIPITRVS--DLSPLDR--LRLPVFAA------------VTPLARDLTTHLGKGRDATSARVSAMMEAVE------RVS-AESI-----PESLTLRASF------------SDLEGSR--SPLAVDPALFDL------------------------PDDTLYSADRA---ITWVAGRELRSGI-DILLAADLALTP---PADGV------LREVDTNGLASGSTVIEAVVHALCEVIERDAQAQ--VEFFALFGAPEGPP-PPLAQI--DPATLP--ASARGWLDALAA---HDLHMAIHDITS------DIGVATFWAVL--------TDARFPTADGVATLTFSGAGTAPRAEVALLRAITEAVQSRV-----GVIHGARDAWNLLPA------------------GRRAESRTIRLRQLLP--------------VQWKPFSAVPSFTST----DLRDD-LGFLLARLAGAGMERVIAADLTRPDI---GIPVVRVRVPGL-SPFLVNRRR---VGDRCLRHLLWP------------------------
115372934 Stigmatella_aurantiaca_DW4/3_1 ----------MLRLPAGWAQASPYRPVSSEETVERLRP--LLPVFGITRIA--NVTGLDV--VGVPVVMV------------CRPNSRSLAVFQGKGLDLASAQASGLMEAVE------NYH-----------------------------------------AERILSPVKLASFQELRFTHA------LVDVASLPRTSARDFHPQLR---LLWIEGHELLSGT-SLWLPFELVHTN---YTLPFPPGSG-TFLPSSNGLASGNHWLEAVCHGLCEVVERDA-----VTLWFLNGAEGRAR-SQL-----ALETVAD-PGCRQVLARFEE---AGLEVAAWDVTS------DVGIPACLCAL--------LEPEGSLQPV---GSVFGMGCHPAREVALRRALTEAAQVRL-----TAITGSRDDLRR---------------------RHYARARETPWLAQLRAGMGT---------QPGCDFHEVPTWRGT----SLEAD-LGWMLERLRGAGLTQVVAVDLTRPEF---QIPVVRVVIPGLEGPSSMPIYV---PGVRARQHLARQ-----GA-----------------
162448810 Sorangium_cellulosum_So_ce_56 PVAQQPAAAGQAAFAFKQFRDGTHRLVPPAETVERLRP--LLPALGITRVA--NVTGLDI--LGIPVVMV------------CRPNARSLSVSQGKGVDLAAAKASGIMEATE------LYH-----------------------------------------AERITSPLKLGSLEELRFTHR------LADVRLLPQRAFSTFHPSAP---LLWIEALDWMRSE-PLWVPFELVHTN---YTLPLPTGSG-AFLTSSTGLASGNHPLEAVSHGICEAVERDA-----GTLWSLLDGGSRRA-TRL-----DLATVDD-AGCRTLLDRCER---AGLDVAAWDIRS------DIDIAAFRCMI--------AER--SPGGLSSLYPAAGMGCHPAREVALSRALTEAVQSRM-----TMISGSRDDMSRAD-------------------YERRLDPELHRRVLQDMRDG----------APGRRFQDVPTREIT----TFEED-IRWELEQLRTAGIEQVAVVDLTKAEI---GIPVVRVVIPGLETIGGLPGYV---PGARARARWTAR----EGKR----------------
159897446 Herpetosiphon_aurantiacus_ATCC_23779 ---------------------MSKTFLSIDDILTRVAPL-VNPRTGILGTAT-ELPRTPG-NPAIPVYST--------NIHCAELAMAESPAGTGVFLEREWAKAKSYCEALE------RYCNVKH------AHQNFIVATR------------QEL------GIEAVDLELFPRCSDAEYRNP-----------------ANPTTPPSNRQPMRWVEGYSLISGQ-PMYVPAIGVYVG---MHPEYAGET--FTTSISTGTALAASYEQAIVTGIGEAIERDA-----LSIAWWQK---LAL-PQV-----DLREFPD-PAFQERLSRVEA---AQIQSYFFDATT------DLGVATIYAVQ--------VAP---HGRL---RTMVMSATRTNPLALPSKVLDESAASRIGIEHSLSQPLPFDPADYRTFMRL-------SDGAAY--YADAATAPAFDFLFEQ--------------TRWRTLDQLPRLDHP----DPAVE-AQRLIDIFRRAGLE-LIVVDLTLPALREVGLYTIKVVAPQLMPFSCNYNARF--LATPRLYSVPER----MGY--PVLAEAELNHWPQPF
145594956 Salinispora_tropica_CNB_440 QRPDTPDPLVLAHHPRPKPRPDAYRLSAPDGYPLPAAAL-VNPVCGVLGAGT-ALTITSP--TTAPVTGS---------VFIRGYGGLLDVSWSGQSSGYDASRSLAYLEGLE------RYA-GTHRR----RNVTPVIAAY------------ADL------GPDALHPDRCGRHPDEVYDTD---------------PILRRFDPQRP---IPWVWGQNLHTGK-PVLVPRRLCFYS---SPAAGDT----FVLSSSSGCATGSCREEAALFGLLELIERDA-----FLLAWYGN---LTL-PRI-----DLDTCP--PVVRALVDRAEL---QGYRLYAFDNRI------DLDVPVVTSLA--------VRH--DGGPG---LLSFAAAAHVDPQQAVTGALAEALTYIP--HQPATVRRRRAELERMADDYTLVRRLP-DHSALF--GLPRMAVHAGSYLNDRGAL-----------PIEQVFAGYRTPGTP----DLRDD-LRRVLDLLSARGLE-AIMVDQTTPEQEAIGLRSVCTVVPGL-LPIDFGWIRQRAPHLPRLRTAPAV----AGLVDAELTDADLRLVPHPF
159038162 Salinispora_arenicola_CNS_205 QRPDTPDPLVLAHQPRPKPRPDTYRLSTPDGYPLPATAL-VNPVCGALGAGT-ALTITSP--TTAPVTGS---------VFIRGYGGLLDVSWSGQSSGYDASRSLAYLEGLE------RYA-GTHRR----RNTIPVVAAY------------ADL------DTDALHPDRCGSHPDEVYDTD---------------PILRRFDPQRP---IPWVWGQNLHTGK-PVLVPRRLCFYS---SPAAGDT----FVLSSSSGCATGSCLEEAALFGMLELIERDA-----FLLAWYGN---LTL-PRI-----DLDTCP--PVVRALVDRAEL---QGYRLYAFDNRI------DLDVPVVTSLA--------VRH--DGGPG---LLSFAAAAHLDPRQAVTGALAEALTYIP--HQPATVRRRRAELERMADDYTLVRRLP-DHSALF--GLPRMAVHAESYLDDRGTL-----------PIEHAFTGYRPPGTP----DLRDD-LRRVLDLLDARGLE-AIMVDQTTPEQEAVGLRSVCTIVPGL-LPIDFGWIRQRAPHLPRLRTAPVV----AGLADTELTDADFRLVPHPF
83320219 Actinomadura_melliaura LPADTPEAAAITLVSRPKPGVETFRAHEVDAAELRRRF--VDDHHGVVGRPR-VDELVAFPTSGAPVGVP---------------GRPTGEMGYGRALDHGSAELVAILEALE------RFG-GIRPG----GRRTVVTASY------------AEL------AGRALDPRTLGLHDSARYDSP--------------GFPFRRFTETAR---CDWVYGHSFARGG-AVLVPESYAYYG---LHRHGADRP--FVYEISNGCALGTCLEEAILHGLLEVAERDA-----FLLAWYSG---ATP-PTI-----DLDATGD-PRIPLMVTRLRQL--TGYDVHAFDITA------EQGVPSVWALA--------TARPGRPDLP---AALCAAGSALLPGKAVRAALHELSTMVE--AHRDSYPGERERAARMADDPELVTEMK-DHALL---YCHPTAAERLSFLFGG--------------PVAGPPPAWPA--HD----DLRDD-LAEMIRRYLDSGLD-VVVVDQTTPEHRAAGLACVKVIVPGA-LPMTFGHARRRVAGLTRISTVPAR----LGWSSTAYPAEP-NPDPHPF
52079456 Bacillus_licheniformis_ATCC_14580 LPEDGPESARISLRPSLKTNPDSFRVRNTDDLKQTLSKDYLDQRTGIFNAKI-YDAILPF--ADMIVNIP---------------LWMGNEGVGGRSHSYEDSELTAILEGLE------RYS-GIEPR----GKRTVVHDTY------------ENV------KDRALDPAKVGLHQAEQYTHP--------------DFPFQPFHPARP---LRWVWGYSFLQKR-PILVPESLAYYS---LGREDS-----FVYETSNGCALGGSLEEAIFHGILEAAERDS-----FLLAWYAR---LPL-RQL-----DLDSSGD-PELRLMTERVRSV--AGYDLHVFNSTM------EYGIPSIWAIA--------KNR--KREGL---NLICSAGAHPDPVKAVKSALHELAGMML--KHDRKFESERSKYHQMLRSPALVREME-DHSLMY--GLPEAEERLSFLLNQS--------------RPLQTFDDAFKKRKKHL--DLTED-LCDLLEAFRSLNLE-VIVVDQTSPVIKRNGLYCVKVLIPGL-IPMTFGQRFIRLEGLERIFTVPKK----LGFAEEPLRPEQLNLHPHPF
152974767 Bacillus_cereus_subsp_cytotoxis_NVH_391_98 VPNDSEEAAILQFKPSLKTNSDNYRCRSIHDLSICLKKDYLNQKTGLLNGKM-QHSLLPF--ADVIVNMP---------------LILGNEGVAGRTHSFKISEATAILEGLE------RYC-GMAPR----GKRTNVYGSY------------RDF------ENIAINPLTVGVHTDEHYNRD--------------GFPFKPFDPDHP---QNWVWGYSLLQNR-SVLVPESLAYYS---LGHKDA-----FVYETSNGCAIGGSIEEAIFHGILEVIERDS-----FLLTWYAQ---LPL-PRI-----DLRSSED-IELQLMIARMQAI--TGYELHVFNATM------EHGIPSIWAIA--------KNT--RKSGM---NLVCAGGAHMDPVRAVKSAIHELAGMLL--IMDENLETNRKTYEQCLQDPYLVTKME-DHSMLY--GLPEAEERLQFLLNTH--------------QPLQTFKEMSYLKSIDK--NLTSD-LSHLLTRLHHAGLD-VIVVDQTVPLIEKNGLSCVKVLIPGM-LPMTFGHHLTRITGLERVLTVPMK----LGYVDQSLTFEQLNPHPHPF
163939156 Bacillus_weihenstephanensis_KBAB4 LPDDTADAAQISLQPSLKTSTETYRCRSIHELNTFLTRDYLDYRTGILNGQM-QHSLLPF--ADVIINMP---------------LLFGNEGVAGRTHSFSLSEATAILEGLE------RYC-GMSPR----GKKTNVHGSF------------REL------EDVALNPLTLGVHTNEHYNRD--------------SFPFKPFDPDYE---QNWVWGYSLLQSR-PLLVPESIAYYS---LGHRDA-----FVYETSNGCAIGGSLEEAIFHGILEIVERDA-----FLLTWYAE---LPL-PRL-----DLSSAND-TELQLMLERLRTI--TGYELYVFNATM------EHGIPSIWVIA--------KNT--RQDGM---NLVCAGGAHMEPIRAIKNAIHEIAGMLL--ITDEELEQKREKYENCLQDPYLVSQME-DHSMLY--GLKEAEERLHFLLRDD--------------APVQTFQEMNALQSFDM--DLTSD-LHQLLNRLHQSGLE-VIVVDQTVPLIEKNGLHCVKVIIPGM-LPMTFGHHLTRVTGLDRVYTVPMT----LGYWAEPLTNESLNPHPHPF
118476823 Bacillus_thuringiensis_str_Al_Hakam LPDDTAEAAAISLQPSLKTSDATYRCRSIHELNTFLTKDYLDYRVGMLNGKM-QHSLLPF--ADVIINMP---------------LMFGNEGVAGRTHSFAISEATAILEGLE------RYC-GMSPR----GKKTNVYGSF------------HDV------EDHALNPLTLGVHTNEHYNRD--------------GFPFKPFDPDYE---QNWVWGYSLSQNR-PILVPESIAYYS---LGHRDA-----YVYETSNGCAIGGSLEEAIFHGILEIVERDA-----FLLTWYAE---LPL-PRL-----DLSSAHD-TELQLMIQRLYTI--TGYELHAFNATM------EHGIPSLWVIA--------KNT--RENGM---NVVCAGGSHLDPVRALKSAIHEIAGMLL--ITDDELEEKREYYENCLQDPYLVNKME-DHSMLY--GLKEAEERLYFLLRGD--------------APVQTFQEMNALQSVDL--DLTSD-LHQLLNRLQQSGLE-VIVVDQTVPLIEKNGLHCVKVIIPGM-LPMTFGHHLTRLTGLDRVYTVPMT----LGYTDEPLTTEQLNPHPHPF
166982096 Bacillus_cereus_AH187 LPDDTADAATISLQPSLKTSDATYRCRSIHELNTFLTKDYLDYRVGMLNGKM-QHSLLPF--ADVIINMP---------------LMFGNEGVAGRTLSFAISEATAILEGLE------RYC-GMSPR----GKKTNVHGSF------------HDL------EDHALNPLTLGVHTNEHYNRD--------------GFPFKPFDPDYE---QNWVWGYSLSQNR-PILVPESIAYYS---LGHRDA-----YVYETSNGCAIGGSLEEAIFHGILEIVERDA-----FLLTWYAE---LPL-PRL-----DLSSAND-TELQLMIQRLYTI--TGYELHAFNATM------EHGIPSLWVIA--------KNT--RENGM---NVVCAGGSHLDPVRALKSAIHEIAGMLL--ITDDELEEKREYYENCLQDAYLVNKME-DHSMLY--GLKEAEERLHFLLRDD--------------APMQTFQEMNGLQSFDL--DLTSD-LHQLLDRLGQFGLE-VIVVDQTVPLIEKNGLHCVKVIIPGM-LPMTFGHHLTRLTGLDRVYTVPMT----LGYTDEPLTTEQLNPHPHPF
consensus/100% ..............................................................................................G.......s......E..E.......h.............................................................................................................hs............................G.s.......s...s..E..b...........................................................................h...................................s..........sh.E..............................................................................................................s..........................s.h.................................................
consensus/95% .....................................................................s........................G.s.....ub..uh.E.hE.......h...................................................................................................pb........hP...h......................ssG.u......pA..psh.EhhbR...............................................h............b..p..........hss..............................s.us......uh..sh.E..................................................................................h..........p.....h......h...s....h....p........h.shb.hhP.h.................................................
consensus/90% ................................................................h....s........................Gbs.....ubh.uh.E.hE......bh..............................................h....................................................pb........hP...h......................osG.u.Gss..pA.hpuh.EhhER........................h......................h.......b.h..b..p..........hssh.h..........................hu.usp.....Ah..sl.Eh.................................................................................h..........s.....h..h...h...sbp..h....p.......sh.shb.lhP.h....................p............................
consensus/85% ........................p...............h.................s.....h..h.s........................Gbu.s...ubhsuh.E.hE......ch.............................................hh.............................................h.h....pb.p.....hhP..hh......................osG.u.Gss..cA.hpuh.EhhERss................h...s.h.....s...h.....h......h......sh.h.hb.ho..........hssh.h...........p..............hu.usc.....Ahbpul.Eh...b........h...................................p................................h..........s...p.h..h...h...ubp.hhhhsbs.......sh.shbhllPsh.........b....s.....p............................
consensus/80% ........................p...............h....s............s.....l.sh.s......................s.G+G.s...ubhsAh.E.hE......Rhs..........s.................................hh....h...............................hpss.....h.h....ph.p.p...hhP.phh......................oNGhusGss..-A.hpul.ElhERcs........hbb.....hs..s.l.....s...h...s.h......hp.....sh.l.hbsho..........hPsh.h...........p..............hu.usc.p...Albpul.Eh...b........h...................................p.............................h..h..........s...p.h..hh..hp..Gb-.hhhhcbs.......sh.sh+lllPuh.........b....s...h.ph.........