Cluster of Orthologous Groups (COG)

Cluster
of Orthologous Groups (COG) is a database of orthologous protein
sequences from several genomes. The database contains eukaryotic orthologous cluster (KOGs) as well as prokaryotic orthologous clusters (COGs). You can download the database by
FTP, or can access the database
online.
Simple and Easy Analysis of Lots of Sequences (SEALS)
SEALS is a set of tools for semi-automated sequence analysis, written
in Perl. At present it is largely unmaintained. Still you can access it from
here.