From: Carmel, Liran (NIH/NLM/NCBI) [F]
Sent: Monday, June 16, 2008 10:51 AM
To: NLM/NCBI List ncbi-seminar
Subject: Special Seminar Monday June 16th

Follow Up Flag: Follow up
Flag Status: Completed

Time: 11:00

Location: B2 library

 

Speaker:

Cristian Castillo-Davis

Department of Biology, University of Maryland

http://www.life.umd.edu/biology/faculty/ccastillo-davis/

 

Title:

cis-regulatory complexity and the structure of animal genomes

 

Abstract:

The structure and complexity of noncoding DNA underlies the dramatic differences in morphology and physiology of different animal groups. An examination of the genomes of 21 representative animal species reveals that all animals, including insects, fish, mammals, birds, and basal chordates share a similar cis-regulatory architecture that strongly affects the structure of their genomes. In particular, we find the spacing of genes (intergenic size) is determined by the complexity of gene expression in cognate genes, with genes involved in developmental processes possessing the longest 5' noncoding sequences in all animal phyla, regardless of genome size. An evolutionary analysis of three representative animal phyla (Arthopoda, Vertebrata, and Nematoda) reveals that these noncoding sequences are also the most highly conserved noncoding sequences in the genome despite the divergence of these groups during the Cambrian over 600 million years ago

 

 

Dr Castillo-Davis would be at NCBI for the entire day. Please contact me if you want to talk to him.

Liran Carmel

 

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Liran Carmel, PhD

National Center for Biotechnology Information (NCBI)

National Library of Medicine (NLM)

National Institutes of Health (NIH)

bldg. 38A, room 5N511H

8600 Rockville Pike, Bethesda, MD 20894, USA

Tel: +1 (301) 594-6478

Fax: +1 (301) 435-7794

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