| |
What's New Archive |
| PubMed | Entrez | BLAST | OMIM | Books | TaxBrowser | Structure |
What's New Archive 2001 2000 1999 1998 1997 1996 1995 1994 BACK |
|
| |||||||||||||||||||||||||||||||||||||||||||||||||
| 12/19 | Nucleotide Sequence Databases' Feature Table Documentation |
Version 2.0 of the Feature Table documentation is available through the
web and
FTP. The
document details the format and definitions of the biological
annotation used in common by the
International Nucleotide Sequence
Database Collaboration in the creation and maintenance of DDBJ, EMBL, and
GenBank sequence records. |
| 11/26 | Malaria Genetics and Genomics |
A new set of Web pages devoted to
Plasmodium falciparum
genetics and genomics is now available. Pages include information relevant
to P. falciparum chromosome mapping and sequencing, including linkage
markers, physical maps, and DNA sequences. The Web site also includes graphical
views and the nucleotide sequence of a chromosome 7 segment containing a
candidate chloroquine resistance gene. This site is expected to grow in
scope and will be integrated with other P. falciparum genome-related
Web pages being developed at NCBI. |
| 10/30 | Clusters of Orthologous Groups |
Clusters of Orthologous
Groups (COGs) were delineated by comparing protein
sequences encoded in seven complete genomes, representing five major
phylogenetic lineages. Each COG consists of individual proteins or groups
of paralogs from at least three lineages and thus corresponds to an
ancient conserved domain. See:
Science 1997 Oct 24;278(5338):631-637. |
| 10/20 | HTG Sequences |
A new set of Web pages describes
High Throughput Genome
(HTG) sequences in GenBank. These pages include information
for both regular GenBank users and sequencing centers about HTG
sequence submission, processing, and access. |
| 09/10 | PSI-BLAST |
A new service called Position-Specific Iterated BLAST, or
PSI-BLAST, is now available in Version 2.0 of the BLAST program suite.
Currently, PSI-BLAST may be used only for comparing protein queries
with protein databases. Given a query, PSI-BLAST performs an initial
gapped BLAST search of the database. In subsequent iterations, it
uses statistically significant alignments from the previous search
to construct a position-specific score matrix for use, in place of
the query and standard amino acid substitution matrix, in the next
round of searching. PSI-BLAST is under development and may change
substantially over time. |
| 08/19 | Gaps in BLAST |
Version 2.0 of BLAST
allows the introduction of gaps (deletions
and insertions) into alignments. With a gapped alignment tool,
homologous domains do not have to be broken into several segments.
Also, the scoring of gapped results tends to be more biologically
meaningful than ungapped results.
The programs, blastn and blastp, offer fully gapped alignments. blastx
and tblastn have "in-frame" gapped alignments and use sum statistics
to link alignments from different frames. tblastx provides only
ungapped alignments. |
| 08/15 | 4800 EST Sequences Recalled |
Because of recently discovered uncertainty about the true nature of the
tissue source, 4829, EST sequences originating from the "Life Tech mouse
brain" cDNA library
have been withdrawn from dbEST and GenBank. |
| 08/12 | Complete Genome, Helicobacter pylori |
The complete genome sequence and annotation of Helicobacter pylori
prepared by The Institute for Genomic Research
(TIGR) is now available through
Entrez Genome,
as well as in GenBank, where the 1.7 megabase sequence
has been separated into 134 records of approximately 11,000 bp each.
The graphical view (as well as a link to underlying data)
of the
complete genome is present in the Genomes
division of Entrez.
The complete sequence is also available by anonymous
FTP;
see
the README. |
| 08/12 | Zea mays Maps |
The UMC (University of Missouri-Columbia RFLP Laboratory) and BNL
(Brookhaven National Laboratory) maps are now available in the
Entrez
Genomes division. These maps are linked to a sequence map generated using
available Zea mays sequences deposited in GenBank. Further information may be
obtained at the Maize Genome
Database. |
| 08/01 | CGAP Announced by Vice President Gore and NCI Director Klausner |
Vice President Gore announced the availability of the NCI's Cancer
Genome Anatomy Project (CGAP) Web site at a
Capitol Hill press conference today. The CGAP site, jointly developed
by NCI and NCBI, brings together data on gene expression in normal,
precancerous, and malignant tissues. The data are the result of
collaborations among many government, academic, and industrial
laboratories. |
| 07/03 | BLAST for Newly Released Microbial Genomes from TIGR |
A new BLAST service for the recently released microbial genomes from
The Institute for Genomic Research (TIGR) is now available.
These unfinished genomes (see
details) are not yet available in GenBank or Entrez.
The genomes are searchable via TBLASTN (a user's protein query
vs. a 6-frame translation of the microbial DNA sequences) using the new
gapped BLAST algorithm (
Altschul et al., 1997, submitted). |
| 06/26 | PubMed Announced by Vice President Gore, NIH Officials |
The availability of
PubMed was officially announced at a
Capitol Hill press conference by Vice President Gore, Senators Harkin, and
Specter and the Directors of NIH, NLM, and NCBI. |
| 03/13 | Cn3D 68K Macintosh Version |
A 68K Macintosh version of
Cn3D, a
3D structure viewer, is now available. |
| 01/25 | Complete Genome, E. coli |
The complete genome sequence and annotation of Escherichia
coli as prepared by Fred Blattner
and colleagues is now available
via Entrez
Genome division, GenBank, and the "nr" BLAST databases.
In Entrez Genome, the entire E. coli genome can be examined and explored at once. Links to the underlying data used to build the graphical representation are provided. In addition, entire-genome data files (GenBank flatfile, FASTA, etc.) for E. coli are available from NCBI's FTP server. See the README file for a description of the various files in the genomes FTP directory at ftp.ncbi.nih.gov. In GenBank itself, the 4.6 megabase E. coli sequence has been split into 400 records of approximately 11,500 bp each. These sequences are available via the usual GenBank Update data files that are available from NCBI's FTP site.
The Japanese Escherichia coli database
has also assembled the E. coli genome and has made their data available on their
World Wide Web server as well
as in a FASTA file present on the NCBI FTP server. |
| 01/24 | THC BLAST |
A new BLAST service for Tentative Human Consensus Sequences (THCs) is now available.
THCs have been generated by The Institute for Genomic Research (TIGR) by automatic
assembly of ESTs from world-wide EST projects into virtual transcripts. |
Revised: June 6, 2002.
1997