2000

12/05	Annotation and Assembly	NCBI released its first assembled and annotated view of the human genome sequence, based on the finished and draft sequences deposited in GenBank by both the public sequencing centers and individual scientists worldwide. The first build presents more than 6,000 contigs, representing roughly 2.8 billion base pairs. This annotated view has been coupled with the NCBI Map Viewer, LocusLink, and AceView.
11/01	BLink	NCBI introduces BLink, or BLAST Link, a new Entrez feature for protein records. BLink displays the graphical output of pre-computed blastp results against the protein non-redundant (nr) database with access to CDD results and taxonomy reports. BLink reports can also be accessed from the Entrez Genome and the COG pages.
10/01	UniSTS	UniSTS reports information about markers collected from public resources including GenBank, RHdb, GDB, and various maps. Each marker report contains primer information, mapping data, and cross-references to the Map Viewer and LocusLink. Marker reports also list GenBank and RefSeq records that contain the primer sequences as determined by Electronic PCR (e-PCR).
09/05	OMIM	OMIM, the Online Mendelian Inheritance in Man database, has been integrated into Entrez. This new interface allows greater flexibility in field searching and provides a new range of capabilities including a "Limits" function that easily allows the restriction of searches by chromosome number and other record attributes. It is also now possible to select and display multiple records in a number of record formats. New user documentation and several FAQs are available. See the OMIM help document for additional information and examples of basic and advanced searches.
08/01	CDD	A new service called CDD, or the Conserved Domain Database and Search Service, is a collection of sequence alignments and profiles representing protein domains conserved in molecular evolution. It includes domains from Smart and Pfam, as well as those contributed by NCBI researchers, and alignments of domains to known 3-dimensional protein structures in the MMDB database. CDD can be used to identify conserved domains in a protein query sequence.
07/25	GEO	GEO, the Gene Expression Omnibus, is now officially open for submissions and retrievals. GEO is a data repository and retrieval resource for gene expression data from any organism or artificial source.
06/15	BLAST Tutorial	A BLAST tutorial and information guide is now available to help both the novice and experienced BLAST user set up and perform a BLAST search, decipher the output, and analyze the results. Additional information includes a Query tutorial for first-time BLAST users, a PSI-BLAST tutorial, and an introduction and glossary for sequence similarity searching.
05/09	Map Viewer	NCBI announced the availability of a new Map Viewer that allows visualization and integration of genome sequence and a variety of maps. The Map Viewer, a software component of Entrez Genome, displays one or more maps that have been aligned to each other based on shared marker and gene names, and, for the sequence maps, based on a common sequence coordinate system.
05/01	Tax BLAST	A new service called Tax BLAST was released. Tax BLAST groups BLAST hits by source organism, according to information in NCBI's Taxonomy database. Species are listed in order of sequence similarity with the query sequence— the strongest match listed first. Three report views are available.
04/07	HomoloGene	HomoloGene, a new gene homology tool, is now available at NCBI. This new service compares nucleotide sequences between pairs of organisms, including human, mouse, rat, and zebrafish, to identify putative orthologs. Curated orthologs are incorporated from a variety of sources via LocusLink.
03/24	Drosophila melanogaster	The assembled, annotated sequence of the euchromatic portion of the fruit fly or Drosophila melanogaster genome is now available in GenBank. The sequence, determined in a collaboration between Celera and the Berkeley Drosophila Genome Project, is described in the March 24, 2000 issue of Science. See the new Drosophila melanogaster homepage for further information.
03/21	New PubMed and Entrez	A completely redesigned version of the PubMed retrieval system has been released. The new version has a single search interface with pull-down menus that display search field limits, indexes, search history, and a clipboard for gathering selected articles. A component called LinkOut was added to provide a more efficient way to store and manage the external links from PubMed and the other Entrez databases. It also broadens the PubMed linking function so that any content provider–publisher, data aggregator, library, specialized research database–can contribute custom URLs that link from specific PubMed records to their own Web sites. Entrez was revised to accommodate additional data resources and facilitate more finely tuned searches demanded by the explosion of data in the sequence, structure, and literature databases. This new release has a completely new back-end, more databases, a new advanced search screen that records a history of all queries done, and a clipboard to save articles of interest for later use.
01/31	PubMed Central	PubMed Central was launched with sample issues from the Proceedings of the National Academy of Sciences (PNAS) and from Molecular Biology of the Cell. PubMed Central will provide free access to full-text articles from journal publishers in the life sciences, both current and archival content. More than twelve more journal titles will be available over the next several months.